| a new epitope presenting system displays a hiv-1 v3 loop sequence and induces neutralizing antibodies. | the principal neutralizing domain, igpgraf sequence, from the v3-loop of hiv-1 was inserted in two positions on the surface of the protein that makes up the capside shell of the insect flock house virus. the hybrid proteins were expressed in insect cells via recombinant baculoviruses. three different hybrids were used as immunogens: two with a single copy of the insert in different positions of the carrier protein and a third with two copies of the insert at the same positions as before. all hyb ... | 1995 | 8578809 |
| immunoreactivity of hcv/hbv epitopes displayed in an epitope-presenting system. | it has been demonstrated that the immunodominant region of the hcv core protein and the hepatitis b surface antigen (hbsag) have high degree of reactivity. in order to construct a chimeric protein that carries hcv and hbv epitopes and possesses immunogenicity to both hcv and hbv, four epitopes derived from residues aa2-21 (epitope c1), aa22-40 (epitope c2) of the core protein, residues aa315-328 (epitope e) of e1 protein of hcv, and residues aa124-147 (epitope s) of hbsag were chosen to be displ ... | 2006 | 16337486 |
| cell-surface accumulation of flock house virus-derived peptide leads to efficient internalization via macropinocytosis. | arginine-rich cell-penetrating peptides (cpps), including human immunodeficiency virus type 1 (hiv-1) tat (48-60) and oligoarginines, have been applied as carriers for delivery of cargo molecules, because of their capacity to internalize into cells and penetrate biological membranes. despite the fact that they have been extensively studied, the factors required for the efficient internalization of cpps are still unclear. in this report, we evaluated the internalization efficiencies of seven cpps ... | 2009 | 19707187 |
| protein a from orange-spotted grouper nervous necrosis virus triggers type i interferon production in fish cell. | family nodaviridae consists of two genera: alphanodavirus and betanodavirus, and the latter is classified into four genotypes, including red-spotted grouper nervous necrosis virus, tiger puffer nervous necrosis virus, striped jack nervous necrosis virus, and barfin flounder nervous necrosis virus. type i interferons (ifns) play a central role in the innate immune system and antiviral responses, and the interactions between ifn and nnv have been investigated in this study. we have found that the ... | 2018 | 29733958 |