| congenital abnormalities in calves associated with akabane virus and aino virus. | | 1978 | 687271 |
| a survey of antibody to aino virus in cattle and other species in australia. | a serological survey of healthy cattle in australia showed that antibodies to aino virus were present in serums from cattle in northern australia and down the east coast as far as central new south wales in 1975, 1976 and 1977, but occurred with a lower frequency than antibodies to akabane virus. in contrast to the findings with akabane virus, no neutralising antibodies to aino virus were detected in serums from camels, dogs or horses. antibodies to both viruses were detected in buffaloes and sh ... | 1978 | 718555 |
| histopathological findings of calves infected experimentally with aino virus. | | 1977 | 917129 |
| a farming systems study of abortion in dairy cattle on the atherton tableland. 2. the pattern of infectious diseases. | the role of infectious agents on dairy farms on the atherton tableland in tropical north queensland was studied as part of a comprehensive investigation into the causes of bovine abortion. the prevalence of antibody in serums collected from 7 herds whose annual abortion rates ranged from 3% to 21% were as follows: leptospira hardjo 49.9% (426/853), l. pomona 0.4% (3/851), bovine virus diarrhoea (bvd) 33.7% (35/104). infectious bovine rhinotracheitis virus (ibr) 11.5% (12/105), akabane virus 92.2 ... | 1989 | 2505741 |
| aino virus, a new a new member of simbu group of arbovirus from mosquitoes in japan. | | 1968 | 5302349 |
| localized conserved regions of the s rna gene products of bunyaviruses are revealed by sequence analyses of the simbu serogroup aino virus. | the complete nucleotide sequence has been determined for the s rna of aino virus, a member of the simbu serogroup (bunyavirus genus, family bunyaviridae). the s rna is 850 nucleotides long (2.76 x 10(5) daltons) and in the viral complementary sequence has a short 5' non-coding region of 34 nucleotides and a more extensive 3' non-coding region of 117 nucleotides. the 3'-5' complementarity of the aino s rna is about 25 residues long, depending on the arrangement. the aino sequence predicts that, l ... | 1984 | 6532000 |
| the incidence of antibody to aino virus in animals and humans in fukuoka. | | 1981 | 6790745 |
| cerebroarthrodigital syndrome: a newly recognized formal genesis syndrome in three patients with apparent arthromyodysplasia and sacral agenesis, brain malformation and digital hypoplasia. | we describe three patients with a complex syndrome of apparent arthromyodysplasia, dyscephaly, sacral agenesis, and hypoplastic digitis. cause is unknown, but an environmental cause is suspected on the basis of ergotamine exposure in one case and diazoxide intake in another, together with suggestive similarities to anomalies seen in animals treated with these drugs and to calves with the australian hydranencephaly/arthrogryposis syndrome caused by akebane or aino virus. pathogenetically the prim ... | 1980 | 7395897 |
| a survey of neutralizing antibody against aino virus in bovine serum in kagoshima, japan. | | 1980 | 7432549 |
| seroprevalence survey of aino virus infection in dairy cattle of fukuoka, japan in 1990. | the seroprevalence and seroconversion to aino virus infection were epidemiologically analyzed in fukuoka prefecture, by a cohort study, in 1990. serum samples (872) were taken from 436 cattle of 128 farms in five different districts at twice sampling with four month-intervals and were tested by a serum neutralizing test with aino virus. in the first sampling (may-july), 38.3% of sera and 40.6% of farms tested were positive and 33.3% of cattle and 40.6% of farms were sero-converted during the per ... | 1995 | 7756398 |
| proliferation and teratogenicity of aino virus in chick embryos. | aino virus (aiv; janar 28 strain) 10(3) tcid50/0.2 ml was inoculated in the yolk sac of 8-day-old chick embryos. recovery and titration of the virus from various organs including the central nervous system (cns) and skeletal muscle were performed at 2, 4, 7, 10 and 13 days after inoculation (pi). aiv was systematically disseminated and proliferated even 2 days pi. the titers of the recovered virus from the cns and from skeletal muscle was the highest at 4 days pi and declined with time, whereas ... | 1996 | 8871535 |
| hydranencephaly, cerebellar hypoplasia, and myopathy in chick embryos infected with aino virus. | pathogenesis of aino virus (aiv), a suspected causative agent of congenital abnormalities of calves, has not yet been established by experimental infection of dams. to investigate the pathogenesis, 10(3) median tissue culture infective doses per 0.2 ml of aiv strain janar 28 was inoculated into the yolk sac of 8-day-old chick embryos. at 4, 7, 10, and 13 days post-inoculation (pi) 20 eggs were opened and macro- and microscopic studies combined with virus recovery and immunohistochemical detectio ... | 1996 | 8952026 |
| teratogenicity of aino virus in the chick embryo. | aino virus (janar 28 strain), a possible agent of a congenital anomaly of calves, was inoculated into the yolk sac of chick embryos at a dose of 10(2), 10(3), 10(4) or 10(5) tcid50 0.2 ml-1 at four, six or eight days of incubation. at 21 days of incubation all the unhatched embryos or hatched chickens in the experimental and control groups were sacrificed for pathological examination. the incidence of hydranencephaly, cerebellar hypoplasia or agenesis and arthrogryposis or scoliosis was highest ... | 1997 | 9243724 |
| sequence determination and phylogenetic analysis of the akabane bunyavirus s rna genome segment. | the nucleotide sequence of the small (s) rna segment of akabane (aka) bunyavirus was determined. the segment is 858 nucleotides long and contains two overlapping open reading frames (orfs), which encode the nucleocapsid (n) and nonstructural (nss) proteins, consistent with other bunyaviruses. comparisons with the aino virus s rna sequence indicated that there is 73.5% identity in nucleotide sequence. however, the sequence identity of the 5' non-coding region of the genomic rna between these two ... | 1997 | 9367371 |
| nucleotide sequencing of s-rna segment and sequence analysis of the nucleocapsid protein gene of the newly isolated akabane virus pt-17 strain. | the nucleotide sequences of the s-rna of akabane viruses jagar-39, obe-1, iriki and the newly isolated pt-17 strains and the aino virus were determined and compared. the results reveal that the s-rnas of the four akabane strains share 96.9% homology in nucleotide sequences. only one amino acid difference out of the 233 amino acids of the nucleocapsid protein (n) and three amino acid differences in the 91 amino acids of the nonstructural protein (nss) were found among the akabane viruses. amino a ... | 1998 | 9739462 |
| aino virus antigen in brain lesions of a naturally aborted bovine fetus. | a bovine fetus aborted at 187 days of gestation was serologically and immunohistopathologically examined. serum and cerebrospinal fluid samples had high titers of virus-neutralizing antibody for aino virus. a severe necrotizing encephalopathy was noted. aino virus antigen was demonstrated in neuroglial cells within the brain lesion. the destruction of developing neuronal cells appeared to be a significant feature of the pathogenesis of lesions due to aino virus infection in the central nervous s ... | 1998 | 9754547 |
| isolation of aino virus from an aborted bovine fetus. | a male fetus of gestation day 187 was aborted from a holstein-friesian cow in an epizootic of the aino virus (ainov) in september 1995. neutralizing antibody titers against ainov were 1:128, 1:16 and 1:64 in the dam serum, fetal ascites and cerebrospinal fluid, respectively. a 10% brain suspension of the aborted fetus was prepared immediately after autopsy, rinsed three times and sonicated before centrifugation. the supernatant was then inoculated into hmlu-1 cell cultures. a cytopathic effect w ... | 1998 | 9819769 |
| detection and differentiation of aino and akabane simbu serogroup bunyaviruses by nested polymerase chain reaction. | reverse transcription-polymerase chain reaction (rt-pcr) and nested pcr were developed to detect and differentiate aino (aino) and akabane (aka) virus s rna. two pairs of aino- and aka-specific primers for nested pcr were synthesized and examined for their capacity to amplify pcr products using 7 simbu serogroup viruses isolated in japan and australia. rt- and nested pcr using aka-specific primers amplified cdna from tinaroo virus rna as well as homologous rna. nested pcr products were different ... | 1999 | 10603165 |
| comparison of intertypic antigenicity of aino virus isolates by dot immunobinding assay using neutralizing monoclonal antibodies. | neutralizing monoclonal antibodies (mabs) against the aino virus were prepared, and the neutralizing epitopes of the virus were defined by competitive binding assay. seven continuous and overlapping neutralizing epitopes existed on the g1 glycoprotein of the aino virus. two antigenic domains were identified and were designated i and ii, with domain ii consisting of six epitopes. dot immunobinding assays (dias) were performed with mabs that recognized these seven neutralizing epitopes. dias were ... | 2000 | 11060092 |
| sequence analysis of the medium rna segment of three simbu serogroup viruses, akabane, aino, and peaton viruses. | the sequence analysis was carried out for the medium (m) rna segment of the akabane virus (akav), aino virus (ainv), and peaton virus (peav) of the simbu serogroup of the genus orthobunyavirus of the family bunyaviridae. the complementary sequences of the m rna segments of akav, ainv, and peav contain a single large open reading frame (orf), like other orthobunyaviruses. the orfs potentially encode 1401 amino acids (aa), 1404 aa, and 1400 aa polypeptides, respectively. the identity of the m segm ... | 2003 | 12727343 |
| detection and quantitation of akabane and aino viruses by multiplex real-time reverse-transcriptase pcr. | a multiplex, quantitive reverse-transcriptase real-time pcr, using mgb taqman chemistry, for detecting akabane virus (akav) and aino virus (ainv) is described. each specific probe was labeled with a different fluorescent dye--vic for detecting akav and 6-carboxy-fluorescein (fam) for detecting ainv. all available sequences of viral s rna were aligned and primers and probes were designed so that akav primers and probes would recognize all akavs but not ainv, and vice versa. the parameters for mul ... | 2004 | 14738981 |
| simultaneous detection of bovine arboviruses using single-tube multiplex reverse transcription-polymerase chain reaction. | single-tube multiplex reverse transcription-polymerase chain reaction (mrt-pcr) assay was developed to detect and identify arboviruses in infected cell-culture fluids and field specimens. the technique was equally sensitive for detecting five different viruses in cell cultures, namely the chuzan, ibaraki, and bluetongue viruses belonging to orbivirus, and the akabane virus and peaton virus belonging to orthobunyavirus, and was less sensitive than former viruses for detecting aino virus belonging ... | 2004 | 15234812 |
| arthrogryposis, hydranencephaly and cerebellar hypoplasia syndrome in neonatal calves resulting from intrauterine infection with aino virus. | to determine the teratogenic potential of aino virus (ainov) in cattle, pregnant cows and fetal cattle were infected with a fresh isolate of ainov. five pregnant cows were inoculated intravenously with the virus at 122 to 162 days of gestation and allowed to give birth. all of the cows developed neutralizing antibodies to the virus, indicating that the cows had been infected with the virus; however, no clinical abnormalities were seen in their six newborn calves, and no specific antibodies to th ... | 2004 | 15369656 |
| molecular epidemiological analyses of the teratogenic aino virus based on the sequences of a small rna segment. | the sequences of a small rna segment of aino virus isolates were analyzed to define the molecular epidemiology and genetic relationships to other species in the genus orthobunyavirus in the family bunyaviridae. the nucleotide and amino acid sequences of the segment were highly conserved among strains isolated from 1964 to 2002 in japan. these japanese isolates were segregated into two distinct lineages, one containing the prototype strain janar28 isolated in 1964 and the other containing strains ... | 2008 | 18077110 |
| an extended outbreak of congenital chondrodysplasia in calves in south east australia. | to report an outbreak of congenital chondrodystrophy in calves in south east australia. | 2008 | 18363985 |
| serosurveillance of viral diseases in korean native goats (capra hircus). | a total of 804 goat sera were collected from 144 goat farms in five regions of south korea during a period between 2005 and 2006 and screened for the antibodies of viral pathogens in ruminants. the individual seropositive rates for each virus were 13.7% (110/804) for bovine herpesvirus-1 (bhv-1), 9.5% (76/804) for bovine parainfluenza type-3 virus (pi-3v), 5.5% (44/804) for akabane virus (akav), 13.3% (107/804) for aino virus (ainv), 2.0% (16/804) for chuzan virus (chuv) and 1.0% (8/804) for bov ... | 2008 | 18840974 |
| serosurveillance for japanese encephalitis, akabane, and aino viruses for thoroughbred horses in korea. | recent global warming trends may have a significant impact on vector-borne viral diseases, possibly affecting vector population dynamics and disease transmission. this study measured levels of hemagglutination-inhibition (hi) antibodies against japanese encephalitis virus (jev) and neutralizing antibodies against akabane virus (akav) and aino virus (ainv) for thoroughbred horses in korea. blood samples were collected from 989 racehorses in several provinces, between october 2005 and march 2007. ... | 2008 | 19043313 |
| serological survey of arthropod-borne viruses among wild boars in japan. | a total of 90 blood samples were collected from wild boars in the kyushu region of japan, and a seroepidemiological survey for 7 arthropod-borne viruses was performed using hemagglutination inhibition tests. the individual seropositive rates for each virus were 52.2% for japanese encephalitis virus (jev), 47.8% for getah virus (getv), 13.3% for akabane virus, 10.0% for aino virus and less than 5% for bluetongue virus, chuzan virus and ibaraki virus. the results indicated that among the 7 viruses ... | 2009 | 19721358 |
| serological and clinical evidence of a teratogenic simbu serogroup virus infection of cattle in israel, 2001-2003. | during the last 35 years, two major outbreaks of akabane virus (akav) infection were recorded in cattle in israel in 1969/1970 and 2002/2003. congenital malformations of calves characterised by the appearance of an arthrogryposis and hydranencephaly syndrome first appeared in israel in 1969. based on epidemiological, clinical, pathological, histopathological and serological data, this syndrome was strongly correlated with seroreactivity to akav, a member of the bunyaviridae, simbu serogroup. in ... | 2004 | 20419647 |
| common, emerging, vector-borne and infrequent abortogenic virus infections of cattle. | this review deals with the aetiology and the diagnosis of bovine viral abortion. while the abortion rates on beef and dairy cattle farms usually do not exceed 10%, significant economic losses because of abortion storms may be encountered. determining the cause of abortions is usually a challenge, and it generally remains obscure in more than 50% of the necropsy submitted foetuses. bovine viral diarrhoea virus and bovine herpesvirus-1 are the most common viruses causally associated with bovine ab ... | 2011 | 21733134 |
| enhanced arbovirus surveillance with deep sequencing: identification of novel rhabdoviruses and bunyaviruses in australian mosquitoes. | viral metagenomics characterizes known and identifies unknown viruses based on sequence similarities to any previously sequenced viral genomes. a metagenomics approach was used to identify virus sequences in australian mosquitoes causing cytopathic effects in inoculated mammalian cell cultures. sequence comparisons revealed strains of liao ning virus (reovirus, seadornavirus), previously detected only in china, livestock-infecting stretch lagoon virus (reovirus, orbivirus), two novel dimarhabdov ... | 2013 | 24314645 |
| evaluating the protective efficacy of a trivalent vaccine containing akabane virus, aino virus and chuzan virus against schmallenberg virus infection. | schmallenberg virus (sbv), an arthropod borne pathogen, spread rapidly throughout the majority of europe since 2011. it can cause a febrile disease, milk drop, diarrhea, and fetal malformation in ruminants. sbv, a member of the simbu serogroup within the genus orthobunyavirus, is closely related to akabane virus (akav) and aino virus (ainov) among others. in the present study, 4 holstein-friesian calves were immunized twice four weeks apart with a multivalent, inactivated vaccine against akav an ... | 2013 | 24313924 |
| virus-induced congenital malformations in cattle. | diagnosing the cause of bovine congenital malformations (bcms) is challenging for bovine veterinary practitioners and laboratory diagnosticians as many known as well as a large number of not-yet reported syndromes exist. foetal infection with certain viruses, including bovine virus diarrhea virus (bvdv), schmallenberg virus (sbv), blue tongue virus (btv), akabane virus (akav), or aino virus (av), is associated with a range of congenital malformations. it is tempting for veterinary practitioners ... | 2015 | 26399846 |
| seroprevalence of five arboviruses in sentinel cattle as part of nationwide surveillance in south korea, 2009-2012. | to investigate the possible circulation of arboviruses in south korea, nationwide surveillance of five arbovirues was conducted in sentinel calves during 2009-2012. we used serum neutralization tests to investigate the presence of antibodies for the aino virus, akabane virus, bovine ephemeral fever virus, chuzan virus and ibaraki virus. in 2009, 2011 and 2012, the seropositive rates for these five arboviruses were all less than 14.1%. in 2010, however, the seropositive rates for aino virus and a ... | 2014 | 25342637 |
| what can akabane disease teach us about other arboviral diseases. | viruses of the simbu serogroup cause lesions to foetuses that are seen at birth and that correlate with the stage of pregnancy at which the dam first contracts the virus. the simbu serogroup comprises arboviruses known to cause outbreaks of abnormal parturitions in domestic ruminants; these abnormalities include abortion, stillbirth, and congenitally deformed neonates. simbu serogroup members include: akabane virus (akav), aino virus, cache valley virus, and schmallenberg virus. lately, dairy he ... | 2016 | 27723047 |
| circulation of a simbu serogroup virus, causing schmallenberg virus-like clinical signs in northern jordan. | schmallenberg virus (sbv)-like clinical cases of abortions in northern jordan in early 2013, together with the emergence of sbv in europe in 2011, its rapid spread within the following years and the detection of this virus in turkey, raised questions about the distribution of sbv or related orthobunyaviruses. to evaluate the occurrence of sbv or related members of the simbu serogroup of orthobunyaviruses in jordan, bulk milk (cattle) and serum samples (cattle, sheep and goat) collected in northe ... | 2015 | 26715241 |
| detection and differentiation of schmallenberg, akabane and aino viruses by one-step multiplex reverse-transcriptase quantitative pcr assay. | schmallenberg virus (sbv), akabane virus (akav) and aino virus (ainv) are members of the simbu serogroup within the genus orthobunyavirus, family bunyaviridae, which can cause reproductive disorders including abortion, stillbirth and congenital malformation in ruminants. because, the clinical signs are similar, confirmatory diagnosis requires viral detection to differentiate infection between these three viruses. | 2015 | 26497392 |
| congenital cerebellar dysplasia in white leghorn chickens (gallus gallus domesticus). | congenital cerebellar anomalies have been rarely reported in birds. we examined cerebellums with disorganized folia from seven specific-pathogen-free white leghorn chickens (gallus gallus domesticus). islands of heterotopic cortex were distributed from the deeper cortices to the medulla in the cerebellum. the characteristic lesions were composed of randomly admixed components of the cerebellar cortex, including purkinje cells, a molecular layer and granular cells. immunofluorescent analysis reve ... | 2014 | 24498885 |
| a large-scale serological survey of akabane virus infection in cattle, yak, sheep and goats in china. | akabane virus (akav) is a member of the simbu serogroup, classified in the genus orthobunyavirus, family bunyaviridae. akav infection can cause abortion, stillbirth, and congenital arthrogryposis and hydranencephaly in cattle and sheep. the distribution and prevalence of akav infection in china is still unknown. a total of 2731 sera collected from 2006 to 2015 in 24 provinces of china from cattle, sheep, goats and yak were examined by serum neutralisation test. the overall seroprevalence rates f ... | 2017 | 28757043 |