| effect of adsorbents on igm and igg measles antibodies. | sera from rabbits immunized with l-16 measles virus absorded with monkey blood cells; kaolin and blood cells; and mncl2 and heparin were examined in haemagglutination inhibition (hi) and neutralization tests. kaolin and mncl2 adsorbed primarily hi igm antibodies from the early immunization period. the adsorbents used had no influence on hi and neutralization igg antibodies. human convalescent serum gave similar results, i.e. only igg antibodies were found and they were not affected by kaolin and ... | 1975 | 1989 |
| obtaining of measles virus haemagglutinin from strain l-16 grown in primary cell cultures. | | 1975 | 1998 |
| encephalitis (author's transl). | | 1975 | 2890 |
| present status of measles and rubella immunization in the united states: a medical progress report. | | 1977 | 12253 |
| possible role of measles, rubella and mumps viruses in multiple sclerosis. | | 1977 | 17282 |
| role of normal cell antigens in the establishment of measles virus in newborn white mice. | the edmontson strain of measles virus was adapted to the brains of newborn white mice to which extracts from african green monkey kidney (vero) cells used for maintenance of measles virus had been injected intracerebrally. the animals showed symptoms of involvement of the central nervous system (pareses, paralyses) which reappeared in subsequent passages. | 1977 | 17289 |
| latent infection and measles meningoencephalitis in syrian hamsters. | a strain designated 42-edmonston was isolated from the brain of a syrian hamster 30 days after inoculation during the neonatal period with the reference "wild" measles virus strain edmonston which produced a latent infection accompanied by production of measles antibody and insignificant pathomorphological changes. intracerebral inoculation with the 42-edmonston strain of newborn, one day-and 5-7-day-old syrian hamsters resulted in the development of acute measles encephalitis with typical clini ... | 1977 | 18920 |
| the role of the nucleus in the replication of measles virus. | the replication of measles and sspe viruses in enucleate bsc-1 cells was measured by plaque assay, and the synthesis of virus-specific antigen was measured by indirect immunofluorescence. titres of infectious virus produced in enucleate cells at 24 hours post inoculation (p.i.) were consistently 100-fold less, and the number of enucleate cells containing virus antigen at 30 hours p.i. was 10-fold less, than in nucleate control cultures. enucleate cells at this time had 30% of the protein synthet ... | 1977 | 18925 |
| immune responses during measles infection in immunosuppressed rhesus monkeys. | rhesus monkeys immunosuppressed with horse anti-human thymocyte gamma-globulin (atg) were infected with measles and simultaneously inoculated with sheep erythrocytes (srbc), a thymus-dependent antigen, and with pneumococcal polysaccaride type iii (sss-iii), a thymus-independent antigen. atg treatment alone suppressed srbc antibody production, had no effect on sss-iii antibody production, and effectively eliminated circulating t cells compared to nonsuppressed monkeys. atg treatment of measles-in ... | 1977 | 19536 |
| measles antibodies in nasal secretions and sera of children with measles. | measles antibodies were determined, in the course of measles, in sera and nasal secretions of 54 and 27 children, respectively. the examinations were performed on the 3rd or 4th day (1st period) and between the 10th and 14th day (2nd period) after onset of rash in both sera and nasal secretions and after 25 to 60 days (3rd period) in sera only. geometric mean titres of antibodies in sera determined by haemmagglutination inhibition (hi) and neutralization tests in the 1st period were 126.3 and 11 ... | 1977 | 20768 |
| genetic characteristics of clones derived from measles virus strain l-16. | the l-16 vaccine strain of measles virus produced in l-41 cell cultures of various size (0.5-0.2 mm in diameter), with clear or opaque centers, thus being genetically heterogeneous by the s and p markes. the clones derived from the l-16 strain differed from it and from each other in a number of genetic properties. clones isolated at different temperatures, 35 degrees or 32 degrees c, differed from each other in thermostability, sensitivity to interferon, interferon-inducing activity, antigenicit ... | 1977 | 22232 |
| stability of the properties of measles virus (strain l-16) clonal variants. | | 1978 | 26206 |
| cell- and antibody-mediated responses to measles and mumps viruses in experimental animals. | monkeys and guinea pigs were immunized with various doses of measles and mumps viruses. a cell-mediated response measured by leukocyte migration inhibition occured during the first two weeks after immunization. in case of measles virus, marked migration inhibition occurred already on the 7th day in monkeys and guinea pigs immunized with high virus doses. the response declined as early as 14 days after immunization in contrast to the group of guinea pigs inoculated with a lower virus dose. in the ... | 1978 | 27968 |
| further characterization of bound measles-specific igg eluted from sspe brains. | tissue residues from 3 sspe brains extracted at neutral ph were thoroughly washed with phosphate-buffered saline and further extracted at acidic ph. the low-ph extracts had significant measles antibody titers, and their measles-specific igg content ranged from 40 to 60% of total igg. agarose-gel electrophoretic analysis of the extracts showed oligoclonal igg bands, most of which disappeared after suitable absorption with measles virus, demonstrating the presence of restricted measles antibody po ... | 1978 | 28073 |
| immunological studies of subacute measles encephalitis in ferrets: similarities to human subacute sclerosing panencephalitis. | ferrets inoculated with subacute sclerosing panencephalitis virus strains d.r. and biken developed a subacute encephalitis. brain extracts, at neutral ph, from these ferrets showed high measles antibody titers, increased concentrations of immunoglobulin g (igg), and higher igg/albumin ratios than those of controls. although the brain extracts of subacute encephalitic animals showed significant synthesis of measles-specific igg (20 to 60% of the total igg) within the central nervous system, the e ... | 1979 | 39084 |
| morphological characterisitcs of the pathological process in the central nervous system of monkeys infected with variants of measles virus strain l-16. | the neurovirulence of l-16 vaccine measles virus strains and its 9 clonal variants was investigated in intracerebrally infected macaca mulatta monkeys. two groups of clones were distinguished: one comprised variants that caused destructive changes of neurons in the brain and diffuse proliferative gliosis, and the second variants that caused changes of a transitory character, connected with the traumatic exposure. | 1979 | 42298 |
| the use of igm antibody responses in the diagnosis of primary infections to measles, rubella, mumps, and m. parainfluenzae viruses. | one-hundred and twenty-seven sera were tested to determine whether a primary infection could be identified by a determination of the class of antibody (igm) detected in serum collected in the period after a viral infection. serum was collected from patients with a history of measles (18 cases), rubella (24 cases), mumps (12 cases), and m. parainfluenzae type 3 infections (9 cases). the results of the serological assays are compared with clinical observations and the limitations of the methods un ... | 1978 | 45605 |
| chronic progressive panencephalitis due to rubella virus simulating subacute sclerosing panencephalitis. | late-onset chronic progressive panencephalitis developed in a 12-year-old boy with congenital rubella syndrome from whose brain rubella virus was isolated. progressive dementia began at eight, and ataxia, choreiform movements, myoclonic seizures, and fine perimacular pigmentation appeared at 11 years of age. the cerebrospinal fluid was minimally pleocytotic and had a total protein of 156 mg per deciliter, of which 52 per cent was gamma globulin. electroencephalography demonstrated generalized me ... | 1975 | 47149 |
| t lymphocyte interaction with viruses and virus-infected tissues. | | 1975 | 47179 |
| immunoperoxidase labeling of subacute sclerosing panencephalitis virus in hamster acute encephalitis. | a hamster neuroadapted strain of subacute sclerosing panencephalitis (sspe) virus induces in the newborn animal an acute encephalitis with ultrastructural features similar to those observed earlier in measles encephalitis and characteristic of a productive viral infection. the direct immunoperoxidase technique, using labeled sspe gamma-globulin, was applied to formaldehyde-fixed thick sections. these were either chopped after perfusion of the animal or cryocut after quick freezing of the tissue ... | 1975 | 47938 |
| letter: cellular immunity in multiple sclerosis. | | 1975 | 48155 |
| rubella-virus infection in juvenile rheumatoid arthritis. | antibody activity against mumps, measles, polio, and rubella viruses was determined in patients with juvenile rheumatoid arthritis (j.r.a.), rubella-vaccine associated arthritis, adult rheumatoid arthritis, other chronic systemic disorders (e.g., systemic lupus and dermatomyositis), and in a matched population of normal, non-rheumatoid (control) children. the antibody levels against mumps, measles, and poliovirus were similar in all patients. rubella-antibody levels in rheumatoid arthritis and o ... | 1975 | 48775 |
| antibody-induced capping of measles virus antigens on plasma membrane studied by electron microscopy. | antibodies specific for measles virus could redistribute ("cap") virus antigens on infected hela cells as shown by transmission and scanning electron microscopy. using an indirect immunoperoxidase technique, infected cells showed diffuse, circumferential distribution of virus antigens over the cell surface when mixed with antibody at 4 c. at 37 c, virus-coated microvilli concentrated on one pole of the cell, leaving the remainder of the plasma membrane devoid of both viral antigens and microvill ... | 1975 | 49437 |
| the use of indirect immunofluorescence to evaluate the gel filtration method of fractionating human immunoglobulins. | the indirect immunofluorescent technique has been shown to be a more sensitive method than either immunoelectrophoresis or gel filtration for testing the efficacy of the gel filtration method in fractionating human immunoglobulins. it has been confirmed that igm fractions of some sera from patients with multiple sclerosis, contain antibody which reacts with measles virus-infected tissue culture cells. | 1975 | 50380 |
| [lymphocyte stimulation tests using measles and distemper virus antigens in the diagnosis of multiple sclerosis]. | | 1975 | 50570 |
| integration of viral genomes. | dna transcripts of infectious rna viruses were found to be integrated in the dna of chronically-infected tissue cultures. dna sequences homologous to rna of measles virus were found in tissues affected with systemic lupus erythemotosus. these data open up a new class of virus-cell interaction that may be a result of cooperation between infectious and oncogenic viruses. | 1975 | 51475 |
| isolation and preliminary characterization of temperature-sensitive mutants of measles virus. | twenty-four genetically stable temperature-sensitive mutants of measles virus were isolated after mutangenesis by 5-azacytidine, 5 fluorouracil, or proflavine. the restricted replication of all mutants at 39 c was blocked subsequent to cell penetration and could not be attributed to heat inactivation of virus infectivity. complementation analysis was made possible through the use of poly-l-ornithine. the members of one complementation group exhibited wild-type rna synthesis at the nonpermissive ... | 1975 | 51932 |
| letter: lymphocyte agglutination in multiple sclerosis. | | 1975 | 52801 |
| letter: lymphocyte transformation in vitro to paramyxovirus antigens in multiple sclerosis. | | 1975 | 53681 |
| letter: measles-virus-induced migration inhibition of human leucocytes: an immunologically unspecific phenomenon? | | 1975 | 53765 |
| letter: antibody production in preclinical hodgkin's disease. | | 1976 | 54615 |
| letter: lymphocyte response to paramyxovirus antigens in multiple sclerosis. | | 1976 | 54623 |
| letter: monucleosis-associated subacute sclerosing panencephalitis. | | 1975 | 54833 |
| letter: cellular immunity in multiple sclerosis. | | 1976 | 55641 |
| is multiple sclerosis an age-dependent host response to measles? | several lines of evidence support the possibility that multiple sclerosis (m.s.) may be an age-dependent host response to measles. in animals, measles evokes different responses depending upon age at inoculation. in man, measles is already known to produce at least two age-dependent responses: risk of subacute sclerosing panencephalitis is increased among those who have had measles before 2 years of age and risk of measles encephalitis increases with age, at least during adolescence. studies of ... | 1976 | 55722 |
| cell-mediated immunity to leukemia virus- and tumor-associated antigens in mice. | cell-mediated immune reactions appear to play an important role in resistance against growth of leukemia cells in mice. possible mechanisms for in vivo protection in two tumor systems are discussed. these tumor models, which are a friend leukemia virus-induced transplantable tumor, fbl-3, and primary murine sarcoma virus (msv) -induced tumors, are strongly antigenic; under some conditions, tumors regress completely. in mice with regressing fbl-3 tumors, cell-mediated cytotoxicity was measured by ... | 1976 | 56223 |
| transfer factor therapy in patients with subacute sclerosing panencephalitis. | thirteen patients with subacute sclerosing panencephalitis (s.s.p.e.) at different stages of the disease were admitted for transfer factor treatment. the transfer factor was prepared from non-selected blood bank donors. the activity of the transfer factor was tested in patients with diseases other than s.s.p.e. and was found to be either clinically or immunologically active. regardless of the number of transfer factor units applied a significant influence on the course of the disease was not app ... | 1975 | 56430 |
| letter: multiple sclerosis and measles. | | 1976 | 56554 |
| editorial: vaccination against measles. | | 1976 | 59191 |
| [kinetics of heat denaturation of whole plasma, erythrocytes and their component proteins]. | | 1976 | 59660 |
| letter: paramyxovirus-like inclusions in brain of patient with severe multiple sclerosis. | | 1976 | 59881 |
| letter: atypical measles encephalitis in leukaemic children in remission. | | 1976 | 60648 |
| vesicular stomatitis virus (measles) pseudotypes: tool for demonstrating defective measles infections. | mixed infection of vero cells with measles and vesicular stomatitis viruses gives rise to phenotypically mixed infections virus particles possessing the properties of pseudotypes. similar results were obtained when vesicular stomatitis virus was used to superinfect a defective measles system. | 1975 | 61189 |
| some characteristics of salt-dependent haemagglutinating measles viruses. | several strains of measles virus which did not agglutinate monkey erythrocytes in phosphate-buffered saline did so in buffer containing 0-8 m-ammonium sulphate. haemadsorption to cells infected with these viruses was also salt-dependent. in a series of tests salt-dependent agglutinin was shown to be a stable structural component of the infectious virion. the relevance of these findings is discussed in the light of previous reports that many measles virus preparations do not agglutinate erythrocy ... | 1976 | 62022 |
| measles virus infection and multiple sclerosis: serological studies. | in 159 patients out of 161 with multiple sclerosis (ms), a significant rise in the level of measles hemagglutination inhibition (hi) antibody was found in the serum and in 92 ms patients the occurrence of measles hi antibody in the csf was significantly more frequent. ms patients showed csf humoral response against measles virus by neutralizing test (nv) (76%) more often than by hemagglutination test (37%). csf fa antibody was found in 60%. in the serum of ms patients the presence of nv, had, fa ... | 1976 | 62037 |
| president's address. the etiology of multiple sclerosis. | the disease multiple sclerosis (ms) presents problems to the morbid anatomist, the histopathologist, the chemical pathologist, microbiologist, immunologist, and the clinician. the pathology is characterized by patches of demyelination scattered throughout the central nervous system which in the later stages undergo gliosis. the earliest lesions appear to be represented by the penetration of lymphocytes from the blood stream into the brain. at this time there is no diagnostic test, but the maj ... | 1976 | 62366 |
| measles-virus-specific immunoglobulin-m response in subacute sclerosing panencephalitis. | measles-virus specific igm and igg responses in sera and cerebrospinal fluid (c.s.f.) of 20 patients with subacute sclerosing panencephalitis (s.s.p.e.) and of two control groups were examined by indirect radioimmunoassay. all s.s.p.e. patients, regardless of the stage of the disease, had high titres of anti-measles antibodies in sera and c.s.f. the antibody activity was associated with both the igm and the igg classes of immunoglobulins. in 7 (35%) of the s.s.p.e. cases the specific igm respons ... | 1977 | 64856 |
| jejunal viral antigen in multiple sclerosis and amyotrophic lateral sclerosis. | | 1977 | 65554 |
| epidemic measles in a highly vaccinated population. | during november, 1975, to may, 1976, measles occurred at a rate of 20.3 cases per 1000 in a purported immunized population, of whom historical and serologic survey revealed that 9 per cent had no history of either measles illness or vaccination and 18 per cent did not have detectable measles antibody. antibody was detectable in 92 per cent of those vaccinated at greater than or equal to 13 months, 80 per cent at 12 months and 67 per cent of those vaccinated when less than one year old (p less th ... | 1977 | 65732 |
| the effect of sodium metrizoate, d-glucosamine and n-acetylglucosamine on the infectivity of polio-, coxsackie, semliki forest- and measles virus in vitro [proceedings]. | | 1976 | 66022 |
| genetical aspects of multiple sclerosis with special regard to histocompatibility determinants. | | 1977 | 66850 |
| cerebrospinal fluid and serum igm in subacute sclerosing panencephalitis. | | 1977 | 67376 |
| new cutaneous phenotype in familial malignant melanoma. | | 1977 | 67377 |
| long-term treatment with h2-receptor antagonists. | | 1977 | 67422 |
| recovery of paramyxovirus from the jejunum of patients with multiple sclerosis. | paramyxovirus, presumably measles, has been recovered by cocultivation or cell-fusion techniques from jejunal biopsy specimens of 6 consecutive patients with multiple sclerosis. virus has been identified by immunofluorescence of antigen in infected hep-2 and bsc-1 cells, by electron microscopy, and by haemagglutination of rhesus-monkey erythrocytes. | 1977 | 68221 |
| jejunal immunopathology in amyotrophic lateral sclerosis and multiple sclerosis. identification of viral antigens by immunofluorescence. | jejunal mucosa from 7 patients with amyotrophic lateral sclerosis (a.l.s.), 20 newly reported patients with multiple sclerosis (m.s.), and 35 control patients without either disease was studied by immunofluorescence. an immune reaction was present in all a.l.s. specimens and consisted of altered ratios of immunoglobulin-labelled cells in the lamina propria, complement-labelled cells in the same location, and, in some, immunoglobulin and complement deposits in the epithelial basement membrane. po ... | 1977 | 68222 |
| antibody response to measles virus in subacute sclerosing panencephalitis. | | 1977 | 68290 |
| measles antigen in jejunal mucosa in multiple sclerosis. | | 1977 | 68412 |
| human histocompatibility determinants and virus antigens: effect of measles virus infection on hla expression. | histocompatibility antigens on the surface of human lymphoblastoid cells were quantified by a microadsorption technique. during the course of measles virus infection, no quantitative or qualitations in surface hla antigens were observed. in contrast, infection with poliovirus type 1 or vesicular stomatitis virus, or treatment with puromycin (50 microgram/ml) resulted in a significant decrease in surface hla. these experiments suggest that an inhibition of host protein synthesis rather than the i ... | 1977 | 68989 |
| cellular immune responses of human milk t lymphocytes to certain environmental antigens. | | 1977 | 69346 |
| measles antigen in the jejunum in multiple sclerosis. | | 1977 | 69907 |
| the influence of a tri-iodinated benzamido-derivative of glucose on measles virus. | | 1976 | 71075 |
| clinical trial of live measles vaccine given alone and live vaccine preceded by killed vaccine. fourth report to the medical research council by the measles sub-committee of the committee on development of vaccines and immunisation procedures. | follow-up of 5000 children given a single dose of live attenuated measles vaccine (schwarz strain) when aged 10 months to 2 years shows a high level of protection in comparison with an unvaccinated group. this protection has been maintained for 12 years. measles in vaccinated children was less severe as well as less frequent throughout the period. there is no evidence from the follow-up so far that a further injection of vaccine is needed; this has been confirmed by measles haemagglutination-inh ... | 1977 | 71396 |
| the measles specificity of the lymphocyte stimulation test with measles complement-fixation antigen. | | 1977 | 71950 |
| complement dependen cytotoxic antibody activity against measles virus in multiple sclerosis. | the presence of measles cytotoxic (ct) and hemagglutination inhibition (hi) antibodies in 195 multiples sclerosis (ms) patients and 251 controls was tested. the measles virus lu carrier cells labeled with 51cr were exposed to serum specimens in the presence of complement in order to test the presence of ct antibody. the analysis of complement dependent ct antibodies against measles virus revealed significantly (p less than 0.01) higher titers in ms patients than in the control group. however, th ... | 1977 | 72792 |
| a heat stable serum inhibitor of an antigen antibody reaction of subacute sclerosing panencephalitis. | a factor which inhibits the antigen antibody reaction was isolated from the sera of patients affected with subacute sclerosing panencephalitis (sspe), multiple sclerosis (ms) and also of control subjects. this factor inhibits the immune reaction between sspe serum iggs and measles virus. this inhibiting factor was detected in the alpha globulin region after agar gel electrophoresis, and is heat stable at 100 degrees c for ten minutes. | 1977 | 72794 |
| serological studies on the etiological role of measles-like virus in subacute sclerosing panencephalitis. | significantly higher csf titers of hemagglutination (hi) measles virus antibody were found in 22 patients with subacute sclerosing panencephalitis (sspe) and more elevated titers of measles virus neutralization (nv) antibody were encountered in 19 patients with sspe than in 50 children and young adults with other neurological diseases. similar differences occurred in the sera of patients and controls. the serum: csf antibody ratio was examined in 15 sspe cases. all but one patient showed reduced ... | 1977 | 72813 |
| absence of measles-virus antigen in jejunum of multiple-sclerosis patients. | measles antigen was not demonstrated in the jejunal tissue of four patients with multiple sclerosis. there was non-specific staining in cells of the lamina propria, basement membrane, and epithelial cells of the jejunum from patients with multiple sclerosis, human controls, and normal monkeys. this staining was not observed after proper absorption of reagents nor after application of evans-blue counterstain. | 1977 | 72954 |
| false-positive measles-specific igm in multiple sclerosis. | | 1978 | 74584 |
| leucocyte migration inhibition test as an index of immunological response to measles virus i. effect of the environment and measles virus on migration of monkey leucocytes. | the parameters of migration inhibition test of leucocytes isolated both from the peripheral blood, spleen and lymph nodes of monkeys cercopithecus aethiops were determined. concentration of measles virus that does not produce nonspecific migration inhibition of leucocyte obtained from sero-negative animals was also defined. | 1977 | 75672 |
| leucocyte migration inhibition test as an index of immunological response to measles virus ii. immunogenic activity of measles virus. | experiments discussed in this paper aimed at obtaining, using cercopithecus aethiops monkeys information on immunogenic activity of measles virus as well as kinetic and persistence of immunological reaction at active and inactivated virus. | 1977 | 75673 |
| sclerodermatous graft-versus-host disease limited to an area of measles exanthem. | a female patient with severe idiopathic aplastic anaemia received a successful bone-marrow transplant from her hla-identical, mixed-lymphocyte-culture-compatible, brother. 8 months after transplantation she had localised cutaneous measles. chronic sclerodermatous changes developed which were indistinguishable from chronic graft-versus-host disease and were limited to the areas of the original exanthem. interaction between viral infection and minor histocompatibility differences probably resulted ... | 1978 | 76022 |
| [current problems in multiple sclerosis (immunogenetic aspect) (review of the literature)]. | | 1978 | 76384 |
| long-term transfer-factor treatment for multiple sclerosis. | in groups of 16 patients with multiple sclerosis, 13 months' double-blind treatment with transfer factor from random normal donors differed from placebo treatment only in producing a temporary restoration of lymphocyte reactivity to measles virus antigen, and did not arrest the degeneration of nerve tissue. | 1978 | 76798 |
| canine distemper virus and multiple sclerosis. | serum samples from patients with multiple sclerosis (m.s.), patients with subacute sclerosing panencephalitis (s.s.p.e.), and controls were examined for virus-neutralising antibodies against measles virus (m.v.) and 2 strains of canine distemper virus (c.d.v.). m.s. and s.s.p.e. patients had higher m.v. antibody titres than controls. in contrast, no significant differences were observed in mean c.d.v.-neutralising antibody titres between m.s. patients and controls. the results, though obtained f ... | 1978 | 77418 |
| [localization of specific antigen in the organs of animals inoculated with different series of live measles vaccine]. | specific antigen was identified by the immunofluorescent test in the walls of the brain blood vessels, in the neurons, and in the glial cells of albino newborn mice and syrian hamsters inoculated subcutaneously with 4 different batches of live measles vaccine. the pathomorphological test of the brain tissue revealed mainly vascular disturbances. the data obtained testify to the presence of residual neurotropism in the attenuated measles virus (strain "l-16"). | 1978 | 77691 |
| virus-antibody titres in chronic glomerulonephritis. | | 1978 | 78370 |
| persistent measles virus infection in vitro and in man. | the characteristics of cell lines persistently infected with measles virus are described. molecular mechanisms for measles virus-persistence in vitro as well as in human disease include defective interfering particles, mutant virus strains, proviral dna, and nonpermissive cell types. the role of measles virus in subacute sclerosing panencephalitis and evidence for measles virus infection in multiple sclerosis, paget's disease, and systemic lupus erythematosus are discussed. | 1978 | 78715 |
| [correlation between progression of multiple sclerosis and immunogenetic as well as immunological factors]. | | 1978 | 79154 |
| optic neuritis and distribution of genetic markers of the hla systems. | | 1978 | 79295 |
| multiple sclerosis specific antigens in ms brains. | antigens in ms and non-ms brains were investigated by means of crossed immunoelectrophoresis. two ms specific antigens were found: a measles antigen which was present in microsomes and cytosole, and an unidentified antigen present only in cytosole. | 1978 | 79296 |
| cellular immunity to encephalitogenic protein in multiple sclerosis. correlations with other laboratory characteristics at different disease courses. | a very suggestive, although non-significant, correlation was found between cellular immunity to encephalitogenic protein in multiple sclerosis and the genetic marker hla-b7 in patients with no disease activity during at least the past 5 years and in those with a chronic progressive disease course during recent years, but not in patients studied longitudinally after a relapse. only the latter group showed a significant correlation with parameters indicating intrathecal synthesis of immunoglobulin ... | 1977 | 79488 |
| in vitro inhibition of subacute sclerosing panencephalitis virus by the antiviral agent ribavirin. | the multiplication in tissue cultures of three isolates of subacute sclerosing panencephalitis virus as well as the edmonston strain of measles virus was observed to be inhibited by various concentrations of the antiviral agent ribavirin (1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide). the blockage of viral replication by ribavirin could be reversed by the simultaneous addition of equimolar concentrations of either guanosine or adenosine. expression of virus-specific antigens was greatly r ... | 1978 | 79625 |
| silver staining and nucleolar patterns in human heteroploid and measles-carrier cells. | | 1978 | 80393 |
| leucocyte migration inhibition test as an evidence of immunological response to measles virus. iii. statistical analysis. | two-way analysis of variance with replications was used for comparing the size of leucocyte migration areas in the samples of blood of monkeys before and after immunization of animals with measles virus. the areas in control samples were compared with those with antigen. size of migration areas differed significantly between control samples and those with antigen only after the immunization of animals. interaction between individual monkeys and presence or absence of antigen was significant only ... | 1978 | 80924 |
| [multiple sclerosis and the immune system. progress and unsolved problems]. | | 1978 | 82904 |
| measles virus in jejunum of patients with multiple sclerosis. | | 1979 | 84146 |
| oligoclonal immunoglobulins in subacute sclerosing panencephalitis and multiple sclerosis: a study of idiotypic determinants. | studies have been made of the idiotypic determinants of subacute sclerosing panencephalitis (sspe) antibodies using rabbit antisera to serum and spinal fluid fractions. evidence is presented indicating that serum and cerebrospinal fluid (csf) anti-measles antibodies, as judged by their idiotypes, differ in their relative concentrations in the two compartments. the results indicate that some of these antibody subpopulations originate within the cns, while others are made largely or entirely outsi ... | 1979 | 85508 |
| demonstration of hla restricted killer cells in patients with acute measles. | the relationship between hla determinants on effector and target cells and cell-mediated cytotoxicity was studied using the release of 51cr from measles virus-infected pha-blasts. hla compatibility between effector and target cells was not required if effector lymphocytes were derived from measles seropositive adults, from a patient with sspe, and from children after live measles vaccination. cytotoxicity was always abolished after removal of fc receptor-bearing lymphoid cells. in these donors, ... | 1979 | 86151 |
| leucocyte migration inhibition test as an index of immunological response to measles virus. iv. blood, spleen, lymph nodes and peritoneal exudate cell reaction. | the migration inhibition test of leucocytes isolated both from the peripheral blood, spleen and lymph nodes as well as peritoneal exudate cells of guinea pigs, immunized with the various doses of measles virus was determined. for in vitro testing of cellular immunity to measles virus, viral antigens could be used in both infective and inactivated form. | 1979 | 87118 |
| generation on infected fibroblasts of human t and non-t lymphocytes with specific cytotoxicity, influenced by histocompatibility, against measles virus-infected cells. | | 1979 | 87462 |
| measles antibodies and kappa-lambda light chain distribution in immunoglobulins of patients affected with multiple sclerosis. | the presence of measles antibodies in serum immunoglobulin g fractions from seven patients affected with multiple sclerosis was investigated with hi technic. the kappa-lambda light chain ratios of all samples under investigation were evaluated. three multiple sclerosis patients, who displayed either fractionation or a tendency towards fractionation in their serum, had slightly elevated measles antibody titers associated to increased kappa/lambda ratios. | 1979 | 87494 |
| adherence of multiple sclerosis lymphocytes to measles infected cells. | adherence of lymphocytes from multiple sclerosis (ms) patients and control subjects to cells persistently infected by measles and control cells was studied. no statistically significant difference between ms patients and controls could be found in this test. lymphocytes adhered more readily to cells infected by measles than to control cells. the cell to cell contacts are made by the tips of the microvillii of the lu cells. | 1979 | 87503 |
| [use of the precipitation reaction for studying viral antibodies in blood sera]. | | 1979 | 89261 |
| [studies on human immunoglobulin preparations: i. viral antibody profiles (author's transl)]. | a study was undertaken to assess the viral antibody spectrum in human immunoglobulin preparations from four different manufacturers for intravenous and/or intramuscular application. studies of the kind seem to be reasonable for calculating the expected therapeutic effect of the administered immunoglobulin. the investigated 16 gammaglobulin batches showed almost the same variety of viral antibodies and only slightly differring antibody titers. it is interesting to note, that antibodies to vaccini ... | 1979 | 89620 |
| purification of measles virus with preservation of infectivity and antigenicity. | measles virus edmonston strain was purified by ultrafiltration followed by two successive sedimentations through sucrose. purified virus retained infectivity and, when used as an immunogen, elicited high titred antibody to measles antigens by conventional serology. the measles preparations were examined by sds-page followed by staining. in addition, following page, the purity of these preparations was assessed immunochemically using antisera directed to measles and host cell antigens. the result ... | 1979 | 90118 |
| genetic basis of multiple sclerosis: hla antigens, disease progression, and oligoclonal igg in csf. | the hla antigens b7 and dw2 occurred at elevated frequencies in 105 multiple sclerosis (ms) patients (49 and 47%, respectively), compared to healthy controls (29 and 30%), especially in ms patients with oligoclonal csf-igg (51 and 50%), in cases with csf-igg index values above 1.5 (64 and 64%), and in those with the most malignant course of the disease (47 and 59%). normal or only slightly elevated frequencies of b7 and dw2 were found in ms patients without oligoclonal csf igg (35 and 29%), norm ... | 1979 | 90443 |
| abnormal levels of antibodies to measles-virus proteins in patient with mental retardation and seizures 24 years after measles encephalitis. | | 1979 | 91066 |
| an unusual form of measles meningoencephalitis. a report of two cases. | two patients are reported with a chronic progressive illness characterized by dementia, ataxia and spasticity. there were no myoclonic jerks and both had normal electroencephalograms (eeg). pathological findings in three brain biopsies were those of viral meningoencephalitis with perivenous demyelination. serological data in both patients indicated the presence of measles virus infection. intracytoplasmic structures resembling measles virus nucleocapsids were found in the brain biopsy of one pat ... | 1979 | 91670 |
| unusual features in a case diagnosed as subacute sclerosing panencephalitis (sspe). | sspe is characterised by progressive mental deterioration, myoclonic and similar motor disorders and final severe comatose states, increase of immunoglobuline g in the csf, strongly elevated antibody titers to measles virus in serum and csf and typical periodic k-complexes in the eeg. the disease appears commonly in childhood and has a fatal course. cases with atypical signs have occasionally been reported. the case described in this paper shows a number of uncommon features: late onset, partial ... | 1979 | 92553 |