| murine hepatitis virus strain 1 as a model for severe acute respiratory distress syndrome (sars). | | 2006 | 17037562 |
| murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in a/j mice. | severe acute respiratory syndrome (sars) is a life-threatening infectious disease which has been difficult to study and treat because of the lack of a readily available animal model. intranasal infection of a/j mice with the coronavirus murine hepatitis virus strain 1 (mhv-1) produced pulmonary pathological features of sars. all mhv-1-infected a/j mice developed progressive interstitial pneumonitis, including dense macrophage infiltrates, giant cells, and hyaline membranes, resulting in death of ... | 2006 | 17041219 |
| development of a dose-response model for sars coronavirus. | in order to develop a dose-response model for sars coronavirus (sars-cov), the pooled data sets for infection of transgenic mice susceptible to sars-cov and infection of mice with murine hepatitis virus strain 1, which may be a clinically relevant model of sars, were fit to beta-poisson and exponential models with the maximum likelihood method. the exponential model (k= 4.1 x l0(2)) could describe the dose-response relationship of the pooled data sets. the beta-poisson model did not provide a st ... | 2010 | 20497390 |
| proteasome inhibition in vivo promotes survival in a lethal murine model of severe acute respiratory syndrome. | ubiquitination is a critical regulator of the host immune response to viral infection, and many viruses, including coronaviruses, encode proteins that target the ubiquitination system. to explore the link between coronavirus infection and the ubiquitin system, we asked whether protein degradation by the 26s proteasome plays a role in severe coronavirus infections using a murine model of sars-like pneumonitis induced by murine hepatitis virus strain 1 (mhv-1). in vitro, the pretreatment of perito ... | 2010 | 20861244 |
| protective effects of long pentraxin ptx3 on lung injury in a severe acute respiratory syndrome model in mice. | the outbreak of severe acute respiratory syndrome (sars) in 2003 reinforces the potential of lethal pandemics of respiratory viral infections. the underlying mechanisms of sars are still largely undefined. long pentraxin ptx3, a humoral mediator of innate immunity, has been reported to have anti-viral effects. we examined the role of ptx3 in coronavirus murine hepatitis virus strain 1 (mhv-1)-induced acute lung injury, a previously reported animal model for sars. ptx3-deficient mice (129/svev/c5 ... | 2012 | 22732935 |