| antigenic and genomic comparisons of some feline parvovirus subspecies strains. | fourteen feline parvovirus (fpv) strains isolated from cats, mink and dogs were comparatively examined on their antigenic and genetic diversities by using monoclonal antibodies against feline panleukopenia virus (fplv) and restriction enzyme analysis of viral dna. mink enteritis virus (mev) strains recently isolated in the northeastern area of the people's republic of china were found to possess more similar antigenic and genetic properties to the antigenic variant virus of canine parvovirus (cp ... | 1991 | 1649516 |
| comparison of feline parvovirus subspecific strains using monoclonal antibodies against a feline panleukopenia virus. | four monoclonal antibodies (mab) against a feline panleukopenia virus (fplv) tu 1 strain, one of the host range variants of feline parvovirus (fpv), were produced and applied for antigenic analysis of fplv, canine parvovirus (cpv) and mink enteritis virus (mev). all mabs were considered to be directed at epitopes on the virus capsid surface because they neutralized the infectivity and inhibited the hemagglutination (ha) of the homologous virus as well as other fpv strains. they were of the mouse ... | 1989 | 2544758 |
| thyroid follicular carcinoma with pulmonary metastases in a beaver (castor canadensis). | an 11-yr-old female beaver (castor canadensis) died after a 3 1/2 mo course of intermittent diarrhea, lethargy and anorexia. a postmortem examination revealed both a necrotizing ulcerative colitis and bilaterally enlarged thyroid glands. histologically, the necrotizing colitis was similar to that caused by canine or feline parvovirus. thyroid glands were multilobulated. lobules were composed of irregularly arranged, variably sized follicles, some of which contained colloid. follicles were lined ... | 1989 | 2810561 |
| parvovirus (feline panleucopaenia virus) plaque formation. | a plaque assay was developed for feline parvovirus (fpv; feline panleucopaenia virus) in a feline embryo (femb) cell line. higher numbers and larger diameter plaques were obtained with a) seeding rates of 0.7 x 10(5) and 1.5 x 10(5) cells cf. 3 x 10(5) and 6 x 10(5) cells/well of 35 mm diameter, b) synchronised cells infected at the g1-s interface cf. nonsynchronised cells and c) 5 to 6 days incubation post inoculation. the plaque assay was standardised by using serum deprivation for 24 hours to ... | 1985 | 2986580 |
| size and antigenic comparisons among the structural proteins of selected autonomous parvoviruses. | the size and antigenic relationships among structural proteins (vps) of canine parvovirus (cpv), feline parvovirus (fpv), porcine parvovirus (ppv), minute virus of mice (mvm) and bovine parvovirus (bpv) were determined by sds-page of radiolabelled, purified virus and immunoprecipitated viral proteins. mature virions of cpv, fpv, ppv and mvm were composed of three vps designated vp1, vp2 and vp3. the corresponding proteins of each virus were similar in molecular weight [79,000 to 82,500 (vp1), 65 ... | 1988 | 3356979 |
| duration of immunity in dogs inoculated with an inactivated feline parvovirus vaccine. | | 1981 | 6916555 |
| detection of canine parvovirus antigens with antibodies to synthetic peptides. | antibodies produced in rabbits against an 18-amino acid peptide (peptide 1, nslpqsegatnfgdigvp) of capsid protein vp2/residues 292-309 of canine parvovirus (cpv) or against an 18-amino acid peptide (peptide 2, gkrntvlfhgpastkgks) of nonstructural protein ns1/residues 391-409 of cpv identified, in immunofluorescence analysis, viral antigens in canine a 72 cells infected with cpv. antibodies to peptide 2 also identified viral antigens in bovine cells infected with bovine parvovirus. in western blo ... | 1996 | 8893795 |
| serosurvey for selected virus infections of wild carnivores in taiwan and vietnam. | serum samples from two leopard cats (felis bengalensis) and four formosan gem-faced civets (paguma larvata taivana) in taiwan, september 1995, and nine leopard cats in vietnam, august and december 1997, were examined for the prevalence of antibodies against feline parvovirus, feline herpesvirus type 1, feline calicivirus and feline immunodeficiency virus. all civets and nine of 11 leopard cats were shown to have antibodies against feline parvovirus (fpv), and fpv's were isolated from mononuclear ... | 1999 | 10479095 |
| isolation of feline parvovirus from peripheral blood mononuclear cells of cats in northern vietnam. | feline parvovirus (fpv) was isolated rather frequently from the peripheral blood mononuclear cells (pbmcs) of cats in northern vietnam by coculturing with mya-1 cells (an interleukin-2-dependent feline t lymphoblastoid cell line) or crandell feline kidney (crfk) cells (a feline renal cell line). efficiency of virus isolation was higher in mya-1 cells than in crfk cells. interestingly, among the 17 cats from which fpv was isolated, 9 cats were positive for virus neutralizing (vn) antibody against ... | 1999 | 10480557 |
| molecular and structural basis of the evolution of parvovirus tropism. | parvoviruses have small genomes and, consequently, are highly dependent on their host for various functions in their reproduction. since these viruses generally use ubiquitous receptors, restrictions are usually intracellularly regulated. a lack of mitosis, and hence absence of enzymes required for dna replication, is a powerful block of virus infection. allotropic determinants have been identified for several parvoviruses: porcine parvovirus, canine parvovirus (cpv), feline parvovirus (feline p ... | 1999 | 10497831 |
| genetic characterization of feline parvovirus sequences from various carnivores. | infections with viruses of the feline parvovirus subgroup such as feline panleukopenia virus (fpv), mink enteritis virus (mev) and canine parvovirus (cpv-2) [together with its new antigenic types (cpv-2a, cpv-2b)] have been reported from several wild carnivore species. to examine the susceptibility of different species to the various parvoviruses and their antigenic types, samples from wild carnivores with acute parvovirus infections were collected. viral dna was amplified, and subsequently anal ... | 2000 | 10644832 |
| a heterogeneous nuclear ribonucleoprotein a/b-related protein binds to single-stranded dna near the 5' end or within the genome of feline parvovirus and can modify virus replication. | phage display of cdna clones prepared from feline cells was used to identify host cell proteins that bound to dna-containing feline panleukopenia virus (fpv) capsids but not to empty capsids. one gene found in several clones encoded a heterogeneous nuclear ribonucleoprotein (hnrnp)-related protein (dbp40) that was very similar in sequence to the a/b-type hnrnp proteins. dbp40 bound specifically to oligonucleotides representing a sequence near the 5' end of the genome which is exposed on the outs ... | 1999 | 10438866 |
| hydranencephaly and cerebellar hypoplasia in two kittens attributed to intrauterine parvovirus infection. | six weeks after vaccination with modified live feline parvovirus vaccine, a cat gave birth to five kittens, three of which died soon afterwards. the remaining two kittens (a and b) survived, but at 8 weeks of age were unable to walk and showed abnormal behaviour, with lack of menace and oculovestibular responses, and severe dysmetria. these signs suggested multifocal disease associated with the cerebrum and cerebellum. magnetic resonance imaging demonstrated severe bilateral (kitten a) or unilat ... | 1999 | 10373292 |
| feline immunodeficiency virus (fiv) infection leads to increased incidence of feline odontoclastic resorptive lesions (forl). | feline odontoclastic resorptive lesions (forl), previously known as 'neck lesions,' are commonly known in domestic, but also in non-domestic cats. they are characterized by odontoclastic resorptive processes, which take place at the dental root and at the periodontium. chronic inflammation of gingiva and periodontium is believed to be an important etiological factor in the development of forl. in this context, various feline viruses have been discussed to play a relevant role in the pathogenesis ... | 1998 | 9839881 |
| new quantitative methods for detection of feline parvovirus (fpv) and virus neutralizing antibody against fpv using a feline t lymphoid cell line. | previously, we reported that a feline t lymphoid cell line, fl74 cells, was very sensitive to feline parvovirus (fpv) infection. in the present study, we developed new quantitative methods for detection of fpv and virus neutralizing antibody against fpv using fl74 cells. the methods presented here were very simple and applicable to both canine parvovirus and feline panleukopenia virus. | 1998 | 9764414 |
| epizootiologic investigations of selected infectious disease agents in free-ranging eurasian lynx from sweden. | serum samples from 106 eurasian lynx (lynx lynx) from across sweden, found dead or shot by hunters in 1993-99, were investigated for presence of antibodies to feline parvovirus (fpv), feline coronavirus, feline calicivirus, feline herpesvirus, feline immunodeficiency virus, francisella tularensis, and anaplasma phagocytophila, and for feline leukemia virus antigen. in addition, tissue samples from 22 lynx submitted in 1999 were analyzed by real-time polymerase chain reaction (pcr) to detect nucl ... | 2005 | 15827211 |
| real-time pcr protocol for the detection of porcine parvovirus in field samples. | this report describes a real-time polymerase chain reaction assay with sybr green for detection of a broad range of porcine parvoviruses (ppv) and accurate virus quantification in porcine tissues. the assay targets the vp2 gene of ppv and the porcine genomic c-myc gene for normalization. the detection limit of the sybr green reaction was shown to be equivalent to 6 x 10(0) to 6 x 10(1) ppv copies/reaction and the overall detection limit equivalent to 0.1 tcid(50)/100 microl. the assay was linear ... | 2006 | 16472875 |
| duration of immunity for canine and feline vaccines: a review. | in our studies aimed at assessing the minimum duration of vaccinal immunity (doi), approximately 1000 dogs have been vaccinated with products from all the major us veterinary biological companies. the doi for the various products is determined by antibody titers for all dogs and, by challenge studies in selected groups of dogs. recently, all major companies that make canine vaccines for the u.s. market have completed their own studies; published data show a 3 years or longer minimum doi for the ... | 2006 | 16707236 |
| detection of feline parvovirus in dying pedigree kittens. | feline parvovirus (fpv) was detected in the intestinal tract contents of 13 pedigree kittens which were fading or died suddenly by the use of a new chromatographic test strip for canine parvovirus (cpv) and fpv. the test appeared to be sensitive and specific for the detection of fpv and was a useful diagnostic aid. in three cases in which virus was grown in cell culture, the isolates were characteristic of fpv and not cpv. cats in the households in which the kittens were reared were regularly im ... | 1998 | 9587196 |
| prevalence of antibodies to feline parvovirus, calicivirus, herpesvirus, coronavirus, and immunodeficiency virus and of feline leukemia virus antigen and the interrelationship of these viral infections in free-ranging lions in east africa. | while viral infections and their impact are well studied in domestic cats, only limited information is available on their occurrence in free-ranging lions. the goals of the present study were (i) to investigate the prevalence of antibodies to feline calicivirus (fcv), herpesvirus (fhv), coronavirus (fcov), parvovirus (fpv), and immunodeficiency virus (fiv) and of feline leukemia virus (felv) antigen in 311 serum samples collected between 1984 and 1991 from lions inhabiting tanzania's national pa ... | 1996 | 8877134 |
| factors associated with pathogen seroprevalence and infection in rocky mountain cougars. | serological and genetic material collected over 15 years (1990-2004) from 207 cougars (puma concolor) in four populations in the rocky mountains were examined for evidence of current or prior exposure to feline immunodeficiency virus (fiv), feline parvovirus (fpv), feline coronavirus (fcov), feline calicivirus (fcv), canine distemper virus (cdv), feline herpesvirus (fhv), and yersinia pestis. serologic data were analyzed for annual variation in seroconversions to assess whether these pathogens a ... | 2006 | 17092891 |
| cerebellar hypoplasia in three sibling cats after intrauterine or early postnatal parvovirus infection. | the present report describes the case of an intrauterine or early postnatal parvovirus infection with subsequent cerebellar hypoplasia in three kittens from the same litter. clinical examination of affected cats revealed neurologic signs indicative of cerebellar ataxia. due to poor prognosis, animals were euthanised and submitted for necropsy. post mortem examination demonstrated variable degrees of cerebellar hypoplasia. histologically, brain lesions were characterised by segmental loss of the ... | 2006 | 17147149 |
| isolation of canine parvovirus from a cat manifesting clinical signs of feline panleukopenia. | twenty-seven feline parvovirus (fpv) isolates were recovered from cats clinically diagnosed with feline panleukopenia (fpl) for assessing antigenic and genomic properties of fpl viruses (fplv) recently prevalent among cats in japan. all isolates, with the exception of one novel isolate, fpv-314, possessed homologous properties, and their subgroups in fpvs were identified as fplv. the fpv-314 isolate, which was from a 1.5-year-old cat which manifested clinical signs of fpl and died on the 13th da ... | 1996 | 8862565 |
| feline parvovirus in pedigree kittens. | | 1996 | 8650911 |
| parasite prevalence in free-ranging farm cats, felis silvestris catus. | no animals tested were positive for feline leukemia virus antigen and chlamydia psittaci antibodies, but all were positive for antibodies to feline calicivirus (fcv), feline herpesvirus 1 (fhv1) and rotavirus. they had antibodies to feline parvovirus (96%), feline coronavirus (84% and cowpox virus (2%). antibody to feline immunodeficiency virus (fiv) was found in 53% of animals, which were less likely to be infected with haemobartonella felis, and had higher fhv antibody titres than cats without ... | 1996 | 8620914 |
| alternative early life vaccination programs for companion animals. | an experimental challenge study of multicomponent vaccination of kittens is reported. seven-to-nine week old, specific pathogen-free kittens received two injections (4 weeks apart) of non-adjuvanted, multicomponent vaccine formulated at the minimum protective dose. kittens were challenged at 4 weeks or 1 year post-vaccination with individual infectious agents. vaccination induced complete protection against challenge from feline parvovirus on both occasions, but at 1 year, the protection against ... | 2007 | 17560595 |
| evolution of canine parvovirus involved loss and gain of feline host range. | canine parvovirus (cpv) type-2 emerged as a new virus infecting dogs in 1978, and it was probably derived as a variant of feline panleukopenia virus or of a closely related virus infecting another carnivore. cpv type-2 was subsequently replaced in nature by antigenically variant viruses (cpv type-2a and cpv type-2b) which now coexist in dog populations worldwide. we show that cpv type-2 isolates did not replicate in cats, but that both cpv type-2a and cpv type-2b isolates replicated efficiently. ... | 1996 | 8560765 |
| [nucleotide sequence and genome structure of mink enteritis virus]. | this paper reports the sequence of the cloned mink enteritis virus (mev) rf dna and its 3' end and 5' end structure predicted. mev genome is near 5064 nucleotides (nt) in length. in its 5' end non-coding region, there are three 51 nt repeated sequences. the nucleotide sequence of mev genome has very high homology with those of canine parvovirus (cpv) and feline parvovirus (fpv), reaching 99.1% and 99.9% respectively in the structure gene region. but they differ notably in 5' end non-coding regio ... | 1993 | 8396953 |
| characterization of the feline host range and a specific epitope of feline panleukopenia virus. | the feline parvovirus subgroup is comprised of viruses isolated from various carnivores, including the dog, cat, mink, raccoon, arctic fox, and raccoon dog. those viruses are > 98% identical in their dna sequences and are very similar antigenically. we have shown that although canine parvovirus (cpv) replicates in numerous feline cell lines in vitro it does not infect cats after parenteral inoculation (u. truyen and c. r. parrish, (1992) j. virol. 66, 5399-5408). here we use recombination mappin ... | 1994 | 7513918 |
| efficiency and safety of an inactivated feline parvovirus vaccine against canine parvovirus infection. | inactivated feline parvovirus vaccine produced in a continuous feline cell line evoked a protective canine parvovirus antibody titer and prevented virus shedding following challenge in previously seronegative puppies. post-vaccinal reactions to the vaccine were not observed in laboratory puppies vaccinated with multiple doses of vaccine or in vaccinated puppies from 5 clinics and/or animal shelters. | 1980 | 7366579 |
| studies of parvovirus vaccination in the dog: the performance of live attenuated feline parvovirus vaccines. | the performance of three live attenuated feline parvovirus vaccines licensed for use in the dog was studied. at the end of the primary vaccination course 67 per cent of dogs had inadequate antibody levels (less than or equal to 32) as measured by a haemagglutination inhibition test. interference by maternal antibody accounted for some of the failures but the fact that there was no significant difference in performance between dogs vaccinated at 12 weeks or 16 weeks of age indicated that maternal ... | 1988 | 3394219 |
| structural polypeptides of feline parvovirus subspecies viruses. | | 1988 | 3246838 |
| nucleotide sequence and genome organization of canine parvovirus. | the genome of a canine parvovirus isolate strain (cpv-n) was cloned, and the dna sequence was determined. the entire genome, including ends, was 5,323 nucleotides in length. the terminal repeat at the 3' end of the genome shared similar structural characteristics but limited homology with the rodent parvoviruses. the 5' terminal repeat was not detected in any of the clones. instead, a region of dna starting near the capsid gene stop codon and extending 248 base pairs into the coding region had b ... | 1988 | 2824850 |
| feline parvovirus propagates in cat bone marrow cultures and inhibits hematopoietic colony formation in vitro. | feline parvovirus (fpv) causes leukopenia in naturally infected cats. we investigated the mechanism of hematopoietic depression by this virus in feline bone marrow cultured in vitro. in suspension cultures we demonstrated fpv propagation and replication using dna molecular hybridization. viral rna and dna were observed by in situ hybridization in about 10% of marrow cells at day 3. granulocytes and their precursors were virtually absent from infected cultures after six days. infected cells showe ... | 1989 | 2546625 |
| [the use of genetic engineering in veterinary medicine with examples from epidemiology, diagnosis and drug production]. | the results of genetic engineering have reached practical veterinary medicine already. nevertheless there is a great lack of knowledge among those veterinarians who usually do not work with these methods. therefore we want to give an introduction into the advantages and dangers of this technology concerning veterinary medicine. some important analytical methods are explained. related viruses such as wee and eee or canine parvovirus, feline parvovirus and mink enteritis virus, or the related coro ... | 1990 | 2112273 |
| characterization of the stage(s) in the virus replication cycle at which the host-cell specificity of the feline parvovirus subgroup is regulated in canine cells. | feline panleukopenia virus (fplv), mink enteritis virus (mev), and canine parvovirus (cpv) are classified as a host-range variants. they show different host-range specificity in vivo and host-cell specificity in vitro. for instance, fplv and mev cannot grow or can grow only inefficiently in canine cell lines such as mdck and the canine fibroma cell line a72. here we have studied the mechanism(s) by which the different cell tropism is mediated in vitro. when fplv or mev was inoculated to a72 cell ... | 1992 | 1322591 |
| kitten mortality in the united kingdom: a retrospective analysis of 274 histopathological examinations (1986 to 2000). | the postmortem findings in 274 kittens were reviewed. the kittens were grouped by age at death: perinatal (< one day), neonatal (one to 14 days), preweaning (15 to 34 days) and postweaning (35 to 112 days); 203 (74 per cent) of the kittens were postweaning and 38 (14 per cent) were preweaning. infectious disease was identified in 55 per cent of the kittens, and 71 per cent of the infectious disease was viral and detected significantly more frequently in rescue shelter kittens than in kittens fro ... | 2002 | 12430997 |
| virucidal efficacy of four new disinfectants. | virucidal efficacy was evaluated for four recently available disinfectants: chlorine dioxide, potassium peroxymonosulfate, a quaternary ammonium compound, and citricidal (grapefruit extract). sodium hypochlorite (3%) and tap water were used as positive and negative controls respectively. feline herpesvirus, feline calicivirus, and feline parvovirus were exposed to the manufacturers' recommended dilutions of the evaluated disinfectants. both chlorine dioxide and potassium peroxymonosulfate comple ... | 2002 | 12022408 |
| hydrocephalus and syringomyelia in a cat. | a 3-month-old male japanese cat with feline parvovirus infection, showing central and cervical nerve abnormalities, was diagnosed as hydrocephalus and syringomyelia by use of magnetic resonance imaging (mri). the cat was maintained clinically by medical treatment even though he could not stand. the mri scans obtained about 5 months later showed that the ventricles had increased in size and the cervical syrinx had extended into the thoracic spinal cord. ventriculoperitoneal (vp) shunt was perform ... | 2001 | 11789613 |
| expansion of tropism of a feline parvovirus to target a human tumor cell line by display of an alpha(v) integrin binding peptide on the capsid. | the autonomous parvoviruses are small, non-enveloped, single strand dna viruses. they occur in many species and they have oncolytic properties. we are modifying the capsid of feline panleukopenia virus (fpv), a parvovirus which normally infects feline cells, with the goal of targeting human tumor cells for potential cancer therapy. using recombinant viruses transducing a luciferase reporter, we show that insertion of a cyclically constrained, integrin-binding peptide at an exposed position on th ... | 2001 | 11313807 |
| predominance of canine parvovirus (cpv) in unvaccinated cat populations and emergence of new antigenic types of cpvs in cats. | serological, sequence, and in vitro host range analyses of feline parvovirus (fpv) isolates in vietnam and taiwan revealed that more than 80% of the isolates were of the canine parvovirus (cpv) type, rather than feline panleukopenia virus (fplv). although parvovirus isolates from three vietnamese leopard cats were genetically related to cpv type 2a or 2b, they had a natural mutation of vp2 residue 300 gly to an asp, resulting in remarkable changes in their antigenic properties. these results ind ... | 2000 | 11112475 |
| comparison of prevalence of feline herpesvirus type 1, calicivirus and parvovirus infections in domestic and leopard cats in vietnam. | a serosurvey of feline herpesvirus type 1 (fhv-1), feline calicivirus (fcv), and feline parvovirus (fpv) in cats from ho chi minh city area in southern vietnam was conducted in december 1998, and we compared the results with our previous results in northern vietnam (hanoi area). the positive rate of fhv and fcv in domestic cats were 44% and 74%, respectively. they were rather higher than those in hanoi area, while the seropositivity of fpv (44%) was similar to that in hanoi area. in leopard cats ... | 1999 | 10651052 |
| Surveillance using serological and molecular methods for the detection of infectious agents in captive Brazilian neotropic and exotic felids. | The aim of the current study was to investigate the exposure of captive wild felids to various infectious pathogens using serological and molecular methods. One hundred and fifty-nine neotropic felids and 51 exotic felids from 28 captive settings in Brazil were tested. While antibodies against Feline parvovirus and Feline coronavirus (FCoV), Feline calicivirus and Bartonella spp. were frequently detected by serologic tests, antibodies against Felid herpesvirus 1 or infection with hemotropic myco ... | 2011 | 21908268 |
| serologic survey for viral and bacterial infections in western populations of canada lynx (lynx canadensis). | a serologic survey for exposure to pathogens in canada lynx (lynx canadensis) in western north america was conducted. samples from 215 lynx from six study areas were tested for antibodies to feline parvovirus (fpv), feline coronavirus, canine distemper virus, feline calicivirus, feline herpesvirus, yersinia pestis, and francisella tularensis. a subset of samples was tested for feline immunodeficiency virus; all were negative. for all other pathogens, evidence for exposure was found in at least o ... | 2002 | 12528455 |
| use of serologic tests to predict resistance to feline herpesvirus 1, feline calicivirus, and feline parvovirus infection in cats. | to determine whether detection of virus-specific serum antibodies correlates with resistance to challenge with virulent feline herpesvirus 1 (fhv-1), feline calicivirus (fcv), and feline parvovirus (fpv) in cats and to determine percentages of client-owned cats with serum antibodies to fhv-1, fcv, and fpv. | 2002 | 12680445 |
| monoclonal antibodies that distinguish antigenic variants of canine parvovirus. | canine parvovirus (cpv) is classified as a member of the feline parvovirus (fpv) subgroup. cpv isolates are divided into three antigenic types: cpv type 2 (cpv-2), cpv-2a, and cpv-2b. recently, new antigenic types of cpv were isolated from vietnamese leopard cats and designated cpv-2c(a) or cpv-2c(b). cpv-2c viruses were distinguished from the other antigenic types of the fpv subgroup by the absence of reactivity with several monoclonal antibodies (mabs). to characterize the antigenicity of cpv- ... | 2003 | 14607871 |
| serosurvey of free-ranging amur tigers in the russian far east. | wild amur tigers (panthera tigris altaica, n=44) from the russian far east were tested for antibodies to feline leukemia virus, feline corona virus (fcov), feline immunodeficiency virus, feline parvovirus (fpv), canine distemper virus (cdv), toxoplasma gondii, and bartonella henselae. antibodies to fcov, cdv, fpv, and t. gondii were detected in 43, 15, 68, and 42% of tigers, respectively. no differences were detected in antibody prevalence estimates between tigers captured as part of a research ... | 2012 | 22247389 |
| late onset cerebellar degeneration in a middle-aged cat. | cerebellar degeneration (abiotrophy) (cd) is a spontaneous and accelerated degeneration of one or several mature cerebellar neuronal cell populations and has been described in many domestic animals, especially in dogs, with numerous breed-related cases. in cats, cd is mentioned as a rare sporadic entity. late onset cds are exceptionally uncommon and only two cases are reported in young adults, both aged 18 months. this report describes clinical and pathological findings of a late onset feline cd ... | 2006 | 16781880 |
| virological survey in free-ranging wildcats (felis silvestris) and feral domestic cats in portugal. | to determine the presence of viral pathogens in natural areas a survey was conducted on an opportunistic sample of fifty eight wild (felis silvestris silvestris) and feral cats (f. s. catus). the biological materials included serum, lung tissue extract and stool. feline leukemia virus p27 antigen was detected in 13/50 serum/lung tissue extract samples (26%), canine distemper virus antibodies were detected in 2/26 serum/lung tissue extract samples (7.7%), feline coronavirus rna was present in 6/2 ... | 2012 | 22424865 |
| feline parvovirus infection and associated diseases. | feline panleukopenia, caused by the single-stranded dna virus feline parvovirus (fpv), is a highly contagious and often lethal disease of cats and other felidae. fpv, but also canine parvovirus (cpv) can be isolated from both healthy and diseased cats. in germany, cpv was detected in only approximately 10% of feline samples, but in southeast asia, reports estimated that up to approximately 80% of diseased cats were infected with cpv. infection spreads rapidly, especially in cells with high mitot ... | 2014 | 24923754 |
| evidence for natural recombination between mink enteritis virus and canine parvovirus. | a virus was isolated from mink showing clinical and pathological signs of enteritis in china. this virus, designated mev/ln-10, was identified as mink enteritis virus (mev) based on its cytopathic effect in the feline f81 cell line, the hemagglutination (ha) and hemagglutination inhibition (hi) assay, electron microscopy (em) and animal infection experiments. the complete viral genome was cloned and sequenced. phylogenetic and recombination analyses on the complete mev/ln-10 genome showed eviden ... | 2012 | 23110843 |
| evolution of cpv-2 and implication for antigenic/genetic characterization. | a few amino acid differences in the viral protein vp2 account for important antigenic and biological changes among feline parvovirus (fpv), canine parvovirus (cpv-2) and cpv-2 variants 2a and 2b. several pieces of evidence suggest that cpv-2 is still evolving as additional amino acid changes occurred within the main antigenic regions of cpv-2 capsid, altering the antigenic profile of the virus and stressing the need for implementing the diagnostic assays. | 2006 | 16791413 |
| seroprevalence of selected infectious agents in a free-ranging, low-density lion population in the central kalahari game reserves in botswana. | twenty-one free-ranging central kalahari lions (panthera leo) exhibited a high prevalence rate of feline herpesvirus (100%) and feline immunodeficiency virus (71.4%). canine distemper virus and feline calicivirus occurred with a low prevalence. all individuals tested negative for feline coronavirus, feline parvovirus, feline leukemia virus, ehrlichia canis, and anaplasma phagocytophilum. | 2007 | 17460117 |
| recombinant feline parvovirus infection of immunized tigers in central china. | | 2017 | 28588292 |
| a serologic assessment of exposure to viral pathogens and leptospira in an urban raccoon (procyon lotor) population inhabiting a large zoological park. | in urban environments, raccoons (procyon lotor) may act as reservoirs for an array of pathogenic organisms, presenting spillover risks for human, domestic animal, and captive (zoo) animal populations. over 5 yr, 159 raccoons from a high-density raccoon population in st. louis, missouri (usa), were surveyed for exposure to canine distemper virus (cdv), canine adenovirus 1 (cav-1); feline parvovirus (fpv; =feline panleukopenia), and several serovars of leptospira interrogans. exposure to each of t ... | 2007 | 17469271 |
| evaluation of inflammation and immunity in cats with spontaneous parvovirus infection: consequences of recombinant feline interferon-omega administration. | administration of recombinant feline interferon-omega (rfeifn) has been proposed for the prophylaxis of canine and feline parvovirosis. in the present study, the influence of the administration of rfeifn on blood markers of inflammation (alpha-globulins, alpha(1)-acid glycoprotein) and immune system activation (gamma-globulins, igg, igm, specific anti-feline parvovirus igg or igm) was evaluated in a cattery developing an outbreak of feline panleukopenia due to feline parvovirus (fpv) infection f ... | 2007 | 17521745 |
| concurrent infection of a cat with cowpox virus and feline parvovirus. | concurrent infection with cowpox and feline parvovirus was diagnosed in a 5-month-old male european short hair cat. microscopical examination of the facial skin, ears and foot pads revealed multifocal to coalescing, ulcerative to necrotizing dermatitis and panniculitis with ballooning epidermal degeneration and eosinophilic cytoplasmic inclusion bodies. immunohistochemistry, polymerase chain reaction testing and virus isolation confirmed infection with a strain of cowpox virus similar to that is ... | 2007 | 17645887 |
| seroepizootiological survey for selected viral infections in captive asiatic lions (panthera leo persica) from western india. | infectious diseases have been responsible for large-scale declines in many endangered animals. disease outbreaks in small populations have probably led to the eventual extinction of such endangered animals in the wild. the endangered asiatic lion (panthera leo persica) population may also face such threats. this was evident from this study on captive asiatic lions from western india, which were sampled from december 1998 to march 1999. fifty-six asiatic lions, including 17 hybrid lions (afro-asi ... | 2007 | 17939348 |
| parvovirus infection in domestic companion animals. | parvovirus infects a wide variety of species. the rapid evolution, environmental resistance, high dose of viral shedding, and interspecies transmission have made some strains of parvovirus infection difficult to control within domestic animal populations. some parvoviruses in companion animals, such as canine parvovirus (cpv) 1 and feline parvovirus, have demonstrated minimal evolution over time. in contrast, cpv 2 has shown wide adaptability with rapid evolution and frequent mutations. this art ... | 2008 | 18501282 |
| onset of immunity in kittens after vaccination with a non-adjuvanted vaccine against feline panleucopenia, feline calicivirus and feline herpesvirus. | the induction of a quick onset of immunity against feline parvovirus (fpv), feline herpesvirus (fhv) and feline calicivirus (fcv) is critical both in young kittens after the decline of maternal antibodies and in cats at high risk of exposure. the onset of immunity for the core components was evaluated in 8-9 week old specific pathogen free kittens by challenge 1 week after vaccination with a combined modified live (fpv, fhv) and inactivated (fcv) vaccine. the protection obtained 1 week after vac ... | 2009 | 18694649 |
| parvovirus infection in a eurasian lynx (lynx lynx) and in a european wildcat (felis silvestris silvestris). | a eurasian lynx and a european wildcat from the same wildlife park were submitted for necropsy examination after sudden death and after death following a clinical history of lethargy, respectively. neither animal had been vaccinated against feline parvovirus (feline panleukopenia virus). feral domestic cats were widespread in the area of the wildlife park and a number of these animals that had been captured had recently died from parvovirus infection. gross and microscopical findings in the two ... | 2009 | 19135211 |
| feline parvovirus infection in an asian palm civet (paradoxurus hermaphroditus). | | 2009 | 19218594 |
| structural comparison of different antibodies interacting with parvovirus capsids. | the structures of canine parvovirus (cpv) and feline parvovirus (fpv) complexed with antibody fragments from eight different neutralizing monoclonal antibodies were determined by cryo-electron microscopy (cryoem) reconstruction to resolutions varying from 8.5 to 18 a. the crystal structure of one of the fab molecules and the sequence of the variable domain for each of the fab molecules have been determined. the structures of fab fragments not determined crystallographically were predicted by hom ... | 2009 | 19321620 |
| evidence for recombination between feline panleukopenia virus and canine parvovirus type 2. | canine parvovirus type 2 (cpv) is a virulent pathogen that emerged in the late 1970s, probably originating from feline panleukopenia virus (fplv) or a closely related carnivore parvovirus belonging to the feline parvovirus (fpv) subspecies. in contrast to fplv, cpv has evolved rapidly since its emergence. the original antigenic type of cpv disappeared more than two decades ago and several new antigenic as well as genetic cpv variants have appeared and spread in the field. both high mutation rate ... | 2009 | 19420841 |
| binding site on the transferrin receptor for the parvovirus capsid and effects of altered affinity on cell uptake and infection. | canine parvovirus (cpv) and its relative feline panleukopenia virus (fpv) bind the transferrin receptor type 1 (tfr) to infect their host cells but show differences in the interactions with the feline and canine tfrs that determine viral host range and tissue tropism. we changed apical and protease-like domain residues by introducing point mutations and adding or removing glycosylation signals, and we then examined the interactions of those mutant tfrs with the capsids. most substitutions had li ... | 2010 | 20200243 |
| genetic variability and viral seroconversion in an outcrossing vertebrate population. | inverse correlations between genetic variability and parasitism are important concerns for conservation biologists. we examined correlations between neutral genetic variability and the presence of antibodies to canine distemper virus (cdv) and feline parvovirus (fpv) in a free-ranging population of raccoons. over 3 years there was a strong relationship between age and seroprevalence rates. most young animals were seronegative to cdv and fpv, but the oldest age class was greater than 80 per cent ... | 2011 | 20667873 |
| serological detection of viral infections in captive wild cats from costa rica. | serum samples from a total of 44 wildcats, 28 margays (leopardus wiedii), 10 ocelots (leopardus pardalis), four jaguaroundis (herpailurus yaguaroundi), one oncilla (leopardus tigrina), and one jaguar (panthera onca) were obtained between january 2001 and august 2002 from the profelis centre for rehabilitation of wild felids, located in the northwestern region of costa rica. forty three samples were tested for antibodies against feline immunodeficiency virus (fiv) and p27 antigen of feline leukem ... | 2011 | 21547230 |
| inbreeding depression increases susceptibility to bovine tuberculosis in lions: an experimental test using an inbred-outbred contrast through translocation. | disease can dramatically influence the dynamics of endangered wildlife populations, especially when they are small and isolated, with increased risk of inbreeding. in hluhluwe-imfolozi park (hip), a small, enclosed reserve in south africa, a large lion (panthera leo) population arose from a small founder group in the 1960s and started showing conspicuous signs of inbreeding. to restore the health status of the hip lion population, outbred lions were translocated into the existing population. in ... | 2011 | 21719814 |
| when cats' ways of life interact with their viruses: a study in 15 natural populations of owned and unowned cats (felis silvestris catus). | in natural populations, virus circulation is influenced by host behavior and physiological characteristics. cat populations exhibit a great variability in social and spatial structure, the existence of different ways of life within a same population may also result in different epidemiological patterns. to test this hypothesis, we used a logistic regression to analyze the risk factors of feline immunodeficiency virus (fiv), feline herpes virus (fhv), feline calicivirus (fcv), and feline parvovir ... | 2011 | 21705099 |
| Role of multiple hosts in the cross-species transmission and emergence of a pandemic parvovirus. | Understanding the mechanisms of cross-species virus transmission is critical to anticipating emerging infectious diseases. Canine parvovirus type 2 (CPV-2) emerged as a variant of a feline parvovirus when it acquired mutations that allowed binding to the canine transferrin receptor type 1 (TfR). However, CPV-2 was soon replaced by a variant virus (CPV-2a) that differed in antigenicity and receptor binding. Here we show that the emergence of CPV involved an additional host range variant virus tha ... | 2012 | 22072763 |
| characterization of parvoviruses from domestic cats in brazil. | to characterize feline parvovirus (fpv) circulating in domestic cats in brazil, 51 fecal samples from unvaccinated domestic cats were collected during 2004-2005. six parvoviruses were characterized by hemagglutination (ha) assay at different ph values and temperatures and by polymerase chain reaction (pcr) using different pairs of primers. however, data obtained from ha and pcr did not allow the discrimination between fpv and canine parvovirus (cpv). two regions of the vp2 capsid gene (1,171-bp ... | 2011 | 21908353 |
| Genetic diversity of parvovirus isolates from dogs and wild animals in China. | We isolated three new parvovirus variants in China. The isolate from a blue fox was related to feline parvovirus, but possessed a mutation of VP2 residue A300P. Isolates from a raccoon dog and a masked civet were antigenically similar to canine parvovirus-2a but had a substitution of VP2 residue G300S. | 2011 | 22102680 |
| preparation of monoclonal antibody of anti-feline calicivirus and establishment of double-antibody sandwich enzyme-linked immunosorbent assay detecting method. | this study aimed to prepare monoclonal antibody of feline calicivirus (fcv) and identify its basic biological characteristics. saturated ammonium sulfate precipitation, combined differential centrifugation, and cesium chloride density gradient centrifugation were used for the purification of fcv. the purified fcv was used as antigen to immunize balb/c mice. the hybridoma lines of anti-fcv monoclonal antibodies were established using cell fusion and hybridoma screening techniques. the subtypes of ... | 2014 | 25222237 |
| myocarditis caused by feline immunodeficiency virus in five cats with hypertrophic cardiomyopathy. | viral infections have been implicated as the cause of cardiomyopathy in several mammalian species. this study describes hypertrophic cardiomyopathy (hcm) and myocarditis associated with feline immunodeficiency virus (fiv) infection in five cats aged between 1 and 4 years. clinical manifestations included dyspnoea in four animals, one of which also exhibited restlessness. one animal showed only lethargy, anorexia and vomiting. necropsy examination revealed marked cardiomegaly, marked left ventric ... | 2016 | 26797583 |
| canine parvovirus type 2 (cpv-2) and feline panleukopenia virus (fpv) codon bias analysis reveals a progressive adaptation to the new niche after the host jump. | based on virus dependence from host cell machinery, their codon usage is expected to show a strong relation with the host one. even if this association has been stated, especially for bacteria viruses, the linkage is considered to be less consistent for more complex organisms and a codon bias adaptation after host jump has never been proven. canine parvovirus type 2 (cpv-2) was selected as a model because it represents a well characterized case of host jump, originating from feline panleukopenia ... | 2017 | 28603036 |
| microrna expression analysis of feline and canine parvovirus infection in vivo (felis). | feline panleukopenia is a common contagious disease with high morbidity and mortality. at present, feline parvovirus (fpv) and canine parvovirus (cpv) variants are the pathogens of feline panleukopenia. many studies have shown that mirnas are involved in virus-host interactions. nevertheless, mirna expression profiling of fpv (original virus) or cpv-2b (new virus) in cats has not been reported. to investigate these profiles, three 10-week-old cats were orally inoculated with 106 tcid50 of the vi ... | 2017 | 29049413 |
| evidence of feline panleukopenia infection in cats in india. | the samples collected from cats showing clinical signs suspected for feline panleukopenia infection were confirmed using various molecular techniques and virus isolation. the suspected samples were confirmed using feline parvovirus specific primers. the partial vp2 gene was submitted to genbank for the first time in india (accession number jq684660.1). the pcr positive samples were further amplified using full length fpv vp2 gene specific primers and sequenced. the blast analysis revealed that t ... | 2014 | 25674629 |
| seroprevalence of viral infections in domestic cats in costa rica. | a cross-sectional survey of a convenient sample of domestic cats from costa rica's greater metropolitan area was carried out to determine the prevalence of antibodies against feline herpesvirus type 1 (fhv-1), feline parvovirus (fpv), feline immunodeficiency virus (fiv) and antigens of feline leukemia virus (felv). blood samples were collected from at least 96 cats from june 1998 to december 2001; data related to the individual cats and household variables were obtained using a questionnaire. an ... | 2009 | 19498296 |
| seroprevalences to viral pathogens in free-ranging and captive cheetahs (acinonyx jubatus) on namibian farmland. | cheetah populations are diminishing rapidly in their natural habitat. one reason for their decline is thought to be a high susceptibility to (infectious) diseases because cheetahs in zoos suffer from high disease-induced mortality. data on the health status of free-ranging cheetahs are scarce, and little is known about their exposure and susceptibility to infectious diseases. we determined seroprevalences to nine key viruses (feline herpesvirus 1, feline calicivirus, feline parvovirus, feline co ... | 2010 | 19955325 |
| age and long-term protective immunity in dogs and cats. | vaccination can provide an immune response that is similar in duration to that following a natural infection. in general, adaptive immunity to viruses develops earliest and is highly effective. such anti-viral immune responses often result in the development of sterile immunity and the duration of immunity (doi) is often lifelong. in contrast, adaptive immunity to bacteria, fungi or parasites develops more slowly and the doi is generally short compared with most systemic viral infections. steril ... | 2010 | 19959181 |