| cloning and characterization of human papillomavirus type 52 from cervical carcinoma in indonesia. | human papillomavirus (hpv) type 52 from a cervical carcinoma in indonesia was molecularly cloned and characterized. by hybridization with cervical carcinoma dnas from indonesian patients, hpv 52 was detected in 3 of 52 cases (6%), whereas hpv 16 and 18 were detected in 8 and 7 cases, respectively (15% and 13%). sequence analysis revealed that the e6-e7 orfs contained several dna binding motifs (cys-x-x-cys) like previously sequenced hpvs. the e6 orf also contained splice donor and acceptor signa ... | 1991 | 1646174 |
| human papillomavirus type 52: a new virus associated with cervical neoplasia. | analysis of biopsies of cervical intraepithelial neoplasia (cin) revealed a high percentage of human papillomavirus (hpv) sequences that would hybridize to a mixture of hpv probes only under conditions of relaxed stringency. the dna sequences of one of these viruses was molecularly cloned and shown to be a new hpv, type 52 (hpv-52). this virus is most closely related to hpv-33. hybridization analysis with restriction fragments of hpv-52 showed collinearity with the hpv-33 genome. dna sequencing ... | 1988 | 2846767 |
| molecular analysis of human papillomavirus type 52 isolates detected in the genital tract of human immunodeficiency virus-seropositive and -seronegative women. | human papillomavirus (hpv) type 52 dna was detected in cervicovaginal lavage samples from 91 (12.4%) of 732 human immunodeficiency virus (hiv)-seropositive women and 23 (7.1%) of 323 hiv-seronegative women (p=.0004). hiv infection was an independent predictor for hpv-52 infection when controlling for age and sexual activity (odds ratio, 2.21; 95% confidence interval, 1.30-3.75: p=.003). we describe the genomic polymorphism of 114 hpv-52 isolates. long control region (lcr) mutations defined 27 hp ... | 2003 | 14624377 |
| genomic polymorphism of human papillomavirus type 52 predisposes toward persistent infection in sexually active women. | we investigated the role of human papillomavirus (hpv) type 52 polymorphism in the persistence of hpv infection, which is a predictor for cervical lesions. cervical samples obtained at 6-month intervals were tested for hpv-52 in 1055 women; 41, 12, and 58 women had persistent, transient, and unclassified hpv-52 infections, respectively. hpv-52 isolates were analyzed by polymerase chain-reaction sequencing of the long control region (lcr), e6, and e7 genes. although age (odds ratio [or], 0.90 [95 ... | 2004 | 15195242 |
| high prevalence of genital human papillomavirus type 52 and 58 infection in women attending gynecologic practitioners in south taiwan. | we attempted to determine the prevalence of genital human papillomavirus (hpv) infection in women attending gynecologic practitioners in south taiwan. | 2006 | 16256180 |
| polymorphism of the l1 capsid gene and persistence of human papillomavirus type 52 infection in women at high risk or infected by hiv. | hiv-seropositive women are at increased risk for human papillomavirus (hpv) infection, which causes high-grade squamous intraepithelial lesions (hsils). hpv-52 is a frequent hpv type in canadian hiv-seropositive women. because variations of the capsid gene, designated the l1 gene, could elicit immune responses that result in different efficiencies in eliminating hpv, we described hpv-52 polymorphism and assessed whether it was associated with hpv-52 persistence in 114 women at risk or infected b ... | 2007 | 17075388 |
| confirmatory real-time pcr assay for human papillomavirus (hpv) type 52 infection in anogenital specimens screened for hpv infection with the linear array hpv genotyping test. | a novel real-time pcr assay for detection of human papillomavirus type 52 (hpv-52) dna (rt-52) was evaluated on 265 anogenital samples. rt-52 had a sensitivity of 98.4% and a specificity of 100% compared to conventional hpv-52 typing assays, including hybridization of pgmy products with an hpv-52-specific probe and pcr sequencing of hpv-52 e6. | 2007 | 17898159 |
| development and validation of a real-time pcr assay specifically detecting human papillomavirus 52 using the roche lightcycler 480 system. | the recently released linear array human papillomavirus (hpv) genotyping test (roche diagnostics) provides a standardized method for simultaneous detection of up to 37 individual hpv types. this test offers a rapid approach for detecting and longitudinal monitoring of patients infected with high-risk (hr) hpv. however, it cannot rule out hpv52 infections in the presence of carcinogenic hpv genotypes 33, 35 and/or 58. as such, often only a non-definitive result of hpv52 presence can be reported. ... | 2008 | 17996311 |
| increase of integration events and infection loads of human papillomavirus type 52 with lesion severity from low-grade cervical lesion to invasive cancer. | infection load and the integration of human papillomaviruses (hpv) have been implicated as determinants for oncogenesis, but whether variation among different hpv types exists remains unclear. we investigated 91 women infected with hpv type 52 (hpv-52), a type that is rare worldwide but common in east asia. the median viral load increased with the severity of the lesion (248 copies/cell equivalent for normal/cervical intraepithelial neoplasia [cin] grade 1, 402 copies/cell equivalent for cin 2, ... | 2008 | 18272718 |
| non-anogenital warty carcinoma associated with human papillomavirus type 52. | | 2009 | 18759790 |
| confirmation and quantitation of human papillomavirus type 52 by roche linear array using hpv52-specific taqman e6/e7 quantitative real-time pcr. | human papillomavirus type 52 is highly prevalent in asia and africa and accounts for 2-3% of total cervical cancer burden worldwide. the roche molecular systems hpv linear array (rms-la uses multiple type (i.e. mixed) probes to detect dna from hpv 52 infection which limits the assay's ability to determine hpv 52 status in the presence of hpv 33, 35, or 58 infection. this report presents a simple to use and highly reproducible hpv 52 type-specific quantitative real-time pcr (rt-pcr) assay based o ... | 2009 | 19022296 |
| t-cell response to human papillomavirus type 52 l1, e6, and e7 peptides in women with transient infection, cervical intraepithelial neoplasia, and invasive cancer. | the e6 and e7 proteins encoded by human papillomaviruses (hpv) are prime targets for therapeutic vaccine development. ninety-five women with hpv 52 infection (33 transient infections, 17 cervical intraepithelial neoplasia grade ii, 15 cervical intraepithelial neoplasia grade iii, and 30 invasive cervical cancers) were examined for t-cell responses using interferon-γ enzyme-linked immunospot (ifn-γ elispot) assay. of the 29 peptides (13 l1, 10 e6, and 6 e7) screened positive by an in vitro peptid ... | 2011 | 21503915 |
| human papillomavirus genotype distribution in cervical intraepithelial neoplasia grade 2/3 and invasive cervical cancer in japanese women. | human papillomavirus vaccines are being introduced worldwide and are expected to reduce the incidence of cervical cancer. here we report a cross-sectional study using a validated human papillomavirus genotyping method to reveal the human papillomavirus prevalence and genotype distribution in japanese women with cervical intraepithelial neoplasia grade 2/3 and invasive cervical cancer. | 2014 | 25156680 |
| analysis of sequence variation and risk association of human papillomavirus 52 variants circulating in korea. | human papillomavirus (hpv) 52 is a carcinogenic, high-risk genotype frequently detected in cervical cancer cases from east asia, including korea. | 2016 | 27977741 |
| human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva. | human papillomavirus (hpv) infection is strongly associated with several human cancers; the most known genotypes involved being hpv 16 and hpv 18. we report the detection of hpv 52 in a sample taken from a 47-year-old patient with squamous cell carcinoma of the conjunctiva of the left eye. the method used for the detection of hpv was real time polymerase chain reaction. the evolution was favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essen ... | 2015 | 25827551 |
| production of recombinant human papillomavirus type 52 l1 protein in hansenula polymorpha formed virus-like particles. | human papillomavirus (hpv) type 52 is a high-risk hpv responsible for cervical cancer. hpv type 52 is common around the world and is the most common in some asian regions. the available prophylactic hpv vaccines protect only from hpv types 16 and 18. supplementing economical vaccines that target hpv type 52 may satisfactorily complement available prophylactic vaccines. a codon-adapted hpv 52 l1 gene was expressed in the methylotrophic yeast hansenula polymorpha, which is used as an industrial pl ... | 2015 | 25639723 |
| distribution of human papillomavirus 52 and 58 genotypes, and their expression of p16 and p53 in cervical neoplasia. | this study investigates the prevalence of human papillomavirus (hpv) 52 and 58 genotypes among women residing in busan, and the expression of p16 and p53 proteins in cervical neoplasia with hpv 52 and 58 infections. | 2014 | 24627691 |
| methylation of human papillomavirus-52 and -58 is a candidate biomarker in cervical neoplasia. | previous studies of human papillomavirus (hpv)16/18 genome methylation have concluded that methylation status of the l1 gene might act as a biomarker for cervical intraepithelial neoplasia (cin). | 2013 | 23871162 |
| bowen disease of the palm associated with human papillomavirus 52. | human papillomavirus (hpv) is a well-known risk factor for many human cancers, especially cervical cancers. among the nonmelanoma skin cancers, bowen disease (bd) of the genitalia and fingers has also been shown to be closely associated with the high-risk types of hpv, especially hpv16. we report a case of bd of the palm, which is a very rare location for bd. in addition to its rare location, hpv52, which is classified as a mucous high-risk hpv type, was detected in the lesion by pcr restriction ... | 2013 | 23659186 |
| genomic polymorphism of human papillomavirus type 52 in women from northeast china. | human papillomavirus (hpv) 52 is an oncogenic hpv type prevalent in asia. the aim of the study was to analyze hpv 52 genetic variations in women from northeast china. to explore the intratypic variants of hpv 52, the genomic regions of l1, e6, e7 and long control region (lcr) of hpv 52, which have been identified in women from northeast china by hpv genoarray test, were analyzed. twenty-five mutations were identified in the regions examined. of the mutations found in the l1 gene, three novel non ... | 2012 | 23203106 |
| human papillomavirus type 52 polymorphism and high-grade lesions of the uterine cervix. | the association between polymorphism of human papillomavirus type 52 (hpv52) and high-grade cervical intraepithelial neoplasia (cin2,3) was investigated in canadian women. hpv-52-positive endocervical specimens collected from 216 women selected from a total of 3,614 participants recruited in two case-control and two cohort studies conducted in canada, were further analyzed by pcr-sequencing of the lcr and e6 gene. overall, the hpv52 lcr prototype was detected more frequently in caucasian women ( ... | 2013 | 23015309 |
| evaluation of the genetic variability of human papillomavirus type 52. | human papillomavirus (hpv) type 52 is one of the high-risk hpv types. its variants can be classified as of asian and european lineages, while little data of hpv 52 variants are available from china. in this study, the complete e6 and l1 genes were amplified and sequenced in 79 samples from eastern guangdong, china. in total, 21 variants were identified, 18 of which could be divided into asian lineage and the other three were phylogenetically related to european lineage. no significant difference ... | 2012 | 22684303 |