| bovine papillomavirus e2 protein activates a complex growth-inhibitory program in p53-negative ht-3 cervical carcinoma cells that includes repression of cyclin a and cdc25a phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein. | the bovine papillomavirus e2 protein can inhibit the proliferation of ht-3 cells, a p53-negative cervical carcinoma cell line containing integrated human papillomavirus type 30 dna. here, we analyzed ht-3 cells to explore the mechanism of p53-independent e2-mediated growth inhibition. expression of the e2 protein repressed expression of the endogenous human papillomavirus type 30 e6/e7 genes. this was accompanied by hypophosphorylation and increased accumulation of p105rb and repression of e2f1 ... | 1999 | 10392903 |