| characterization of the complete rhpv 1 genomic sequence and an integration locus from a metastatic tumor. | the complete nucleotide sequence of the rhesus papillomavirus type 1 (rhpv 1) genome was determined. the genome is 8026 nucleotides in length and has a genomic organization similar to that of other characterized papillomaviruses. sequence comparison of rhpv 1 to other papillomaviruses found similarities closest to hpv 16, a sexually transmitted human virus with a high oncogenic potential. slight differences in the glucocorticoid responsive elements may explain disparate reliance upon added dexam ... | 1991 | 1847267 |
| rhesus papillomavirus type 1 cooperates with activated ras in transforming primary epithelial rat cells independent of dexamethasone. | rhesus papillomavirus type 1 (rhpv-1) was recently cloned from a rhesus monkey lymph node metastasis of a penile squamous cell carcinoma. in this paper, we demonstrate that rhpv-1 cooperates with the activated ras oncogene to transform primary cells at a level comparable to human papillomavirus type 16. the viral dnas were cloned such that their expression was under the control of their natural promoter elements. unlike human papillomavirus type 16, rhpv-1 dna cooperated with ras independently o ... | 1991 | 1851883 |
| a rhesus monkey model for sexual transmission of a papillomavirus isolated from a squamous cell carcinoma. | recently we molecularly cloned and characterized a papillomavirus from a lymph node metastasis of a primary penile carcinoma found in a rhesus monkey; this virus species, rhesus papillomavirus type 1 (rhpv-1), is similar to oncogenic human papillomaviruses (hpvs), such as hpv-16 or hpv-18, in that the rhpv-1 dna was found to be integrated in the tumor cell dna. to compare the sexual transmission and oncogenic nature of rhpv-1 with these hpvs, we undertook an extensive retrospective study of a gr ... | 1990 | 2172976 |
| molecular cloning and characterization of the dna of two papillomaviruses from monkeys. | benign and malignant lesions from monkeys were analyzed for the presence of papillomavirus (pv) dna. by hybridization with different pv dna probes under conditions of lowered stringency, two tumors were found to contain pv-specific dna sequences: (1) a cutaneous papilloma from a colobus monkey; and, (2) a lymph node metastasis of a squamous cell carcinoma of the penis from a rhesus monkey. analysis of the dna of the papilloma from the colobus monkey indicated the presence of extrachromosomal dna ... | 1988 | 2842954 |
| serological and molecular evidence of rhesus papillomavirus type 1 infections in tissues from geographically distinct institutions. | we have previously demonstrated the presence of rhesus monkey papillomavirus type 1 (rhpv-1), from molecular and pathological evidence, in a mating group within a single institution. we have now also obtained a number of fresh or archival tissues of rhesus monkeys from other geographically distinct institutions. using pcr amplification, we observed two animals from one of these institutions and five animals from another which demonstrated rhpv-1 dna sequences. in addition we molecularly cloned t ... | 1995 | 7844551 |
| the products of the e5, e6, or e7 open reading frames of rhpv 1 can individually transform nih 3t3 cells or in cotransfections with activated ras can transform primary rodent epithelial cells. | rhesus papillomavirus (rhpv) type 1 was recently shown to cooperate with the activated ras oncogene to transform primary rodent epithelial cells at a level comparable to hpv 16. in similar cotransfection studies, subgenomic portions of rhpv 1 driven by either their natural or a strong heterologous promoter were used in primary baby rat kidney cells to demonstrate that transforming properties of rhpv 1 could be localized individually to the e5, e6, and e7 open reading frames. fully transformed ce ... | 1993 | 8396814 |
| the e5 gene product of rhesus papillomavirus is an activator of endogenous ras and phosphatidylinositol-3'-kinase in nih 3t3 cells. | we examined the effect of two rhesus papillomavirus 1 (rhpv) oncogenes on cytokine-induced signal transduction pathways leading to the possible activation of ras protein (p21ras) and phosphatidylinositol kinase. p21ras in both the activated (gtp-bound) and inactivated (gdp-bound) states were quantitated. nih 3t3 cell lines expressing the rhpv 1 e5 gene or epidermal growth factor receptor cdna had about a sixfold higher ratio of p21ras-bound gtp to p21ras-bound gdp as compared with parental nih 3 ... | 1996 | 8917513 |
| genomic diversity and interspecies host infection of alpha12 macaca fascicularis papillomaviruses (mfpvs). | alpha human papillomaviruses (hpvs) are among the most common sexually transmitted agents of which a subset causes cervical neoplasia and cancer in humans. alpha-pvs have also been identified in non-human primates although few studies have systematically characterized such types. we cloned and characterized 10 distinct types of pvs from exfoliated cervicovaginal cells from different populations of female cynomolgus macaques (macaca fascicularis) originating from china and indonesia. these includ ... | 2009 | 19716580 |
| emerging theme: cellular pdz proteins as common targets of pathogenic viruses. | more than a decade ago three viral oncoproteins - adenovirus type 9 e4-orf1, human t-lymphotropic virus type 1 tax, and high-risk human papillomavirus e6 - were found to encode a related carboxyl-terminal pdz domain-binding motif (pbm) that mediates interactions with a select group of cellular pdz proteins. recent studies have shown that many other viruses also encode pbm-containing proteins that bind to cellular pdz proteins. interestingly, these recently recognized viruses include not only som ... | 2011 | 21775458 |