| [infectivity and oncogenicity of simian adnovirus sa7(c8) dna and the infectivity of human adenovirus type 6 dna]. | | 1978 | 96604 |
| [immunosuppression induced by respiratory viruses (influenza virus, adenovirus) in mice]. | the influence of respiratory viruses (adenovirus, influenza virus) on humoral immune response to heterologous t-dependent and t-independent antigens was studied. it was shown that inoculation of mice by the influenza virus (a/pr8/34-a/pr/8) 3 days before sheep red blood cells administration led to the inhibition of antibody forming cell (afc) and immunoglobulin, forming cell (ifc) increase on 69% and 59% respectively. adenovirus type 6 induced the similar suppression of afc and ifc formation. th ... | 1991 | 1878568 |
| effect of human adenovirus on natural killer cell activity in mice. | the influence of human adenovirus type 6 on the natural killer cell activity in mice has been investigated. the cytotoxic effect of splenic mononuclear cells of different mouse strains (balb/c, cba and blo) against yac-1 cells was estimated using a 51cr release system assay. the effector cells responsible for cytotoxicity were identified by percoll density gradient fractionation as lgl cells. a single intraperitoneal injection of the virus enhanced the natural killer activity in all three strain ... | 1985 | 2424258 |
| the role of macrophages in adenovirus-induced immunosuppression in mice. | a decreased humoral immune response to sheep red blood cells (srbc) was demonstrated in cflp mice inoculated with human adenovirus type 6 (ad6 virus). the suppressive effect depended on the inoculation sites of the virus and srbc. inoculation by the same route, i.e. intraperitoneally (i.p.), resulted in a significant decrease of the humoral immune response to srbc. when administering the virus and srbc at different sites, no inhibitory effect could be detected. immunosuppression was prevented by ... | 1985 | 2859763 |
| impaired interleukin 2 production by spleen cells from mice infected with human adenovirus. | spleen cells from mice infected with human adenovirus type 6 (ad6) showed defective interleukin 2 (il2) production 3-5 days after the infection. the response of spleen cells to exogenous il 2 was also deficient. the impaired capacity of concanavalin a--(con a)-activated spleen cells from ad6--infected mice to utilize il 2 seemed to be related to the depressed capacity of the infected splenocytes to express il 2 receptors. the immunologic dysfunction following infection with ad6 may be a conseque ... | 1991 | 1686960 |
| the role of histopathology in hepatic transplantation. | in hepatic transplantation, the recipient and the graft must manage a difficult symbiosis. the causes that can unbalance the mutual adaptation are various, but the clinical-biochemical hepatic graft syndromes they produce are not specific. morphological study of the graft shows a distinct pattern for each type of dysfunction etiopathogeny. such study may find: (1) immune attack: acute rejection or chronic rejection; (2) technical complications in the biliary tract or in the blood perfusion of th ... | 1992 | 1523358 |
| immunoenhancement and suppression induced by adenovirus in chicken. | chickens injected intravenously (i.v.) with human adenovirus type 6 (ad6) reveal a 2-17-fold increase in the number of plaque-forming cells producing antibody (ab) against sheep red blood cells (srbc) 2-6 days after virus infection. further, polyclonal b-cell activation has been demonstrated by the quantitation of immunoglobulin-producing cells (igpc) and cells producing immunoglobulin (ig) of igm isotype (igpc mu) in the spleen of chicken inoculated with ad6. ad6 infection in chicken results in ... | 1992 | 1360755 |
| [fragmentation of human adenovirus type 6 dna by means of restrictase of e. co r i and bam i]. | the effect of restricting endonucleases of e. co ri and bami on dna of human adenovirus type 6 was studied. e. co ri and bami restrictases cleave virus dna into 4 fragments each. the molecular weight of e. co ri fragments was: a--17.5x10(6), b--3.63x10(6), c--1.56x10(6), d--1.05x10(6), those of bami fragments: a--9.7x10(6), b--7x10(6), c--4.09x10(6), d--3.1x10(6). by means of terminal nucleotidyltransferase and the procedure of partial dna hydrolysis, the alteration of fragments obtained by the ... | 1976 | 795161 |
| isozymic forms of some energy metabolism enzymes during oncovirus-induced cell transformation. | kinetic studies of changes in isozymic forms of hexokinase, lactate and malate dehydrogenase and in total hexokinase activity during viral carcinogenesis were carried out. the test systems were rat embryo fibroblasts infected with an oncogenic variant of human adenovirus type 12 and an infectious adenovirus type 6, intact ref cultures in different stages of growth (log and stationary phase), and hamster sarcoma a12 and rat reticulosarcoma 321-rrs cell cultures. molecular isozymic forms of the st ... | 1978 | 658548 |
| [physico-chemical properties of dna of human adenovirus type 6]. | physico-chemical characteristics of human adenovirus type 6 dna were studied. the sedimentation constant of adenovirus type 6 dna was shown to be 32.7s. the intrinsic viscosity of dna was on the average 93.8 dl/g. the average size of the molecular mass determined by the results of sedimentation and viscosimetry was 23.5 x 10(6) daltons which agreed favourably with the value calculated from the data of electron microscopic determination of the length of dna molecule. the buoyant density of dna in ... | 1978 | 645056 |
| [gc-pair distribution in the dna of simian sa7 and human type 6 adenoviruses]. | the buoyant density values in cesium chloride of dna fragments of simian adenovirus sa7 obtained with restricting endonucleases of r. ecori, r. bamhi, r. sali and human adenovirus type 6 dna fragments obtained with restricting endonucleases of r. ecori and r. bamhi were determined. on the basis of the buoyant density values for these fragments the content of gc pairs in them was calculated. using the known position of the fragments in the physical map of these dnas, the distribution of gc pairs ... | 1979 | 524856 |
| [physical characteristics of human adenovirus type 6]. | the size, chemical composition and the buoyant density of the virion, sedimentation and diffusion constants of human adenovirus type 6 were determined. the molecular mass of the virion was calculated on the basis of the values of sedimentation and diffusion constants and electron microscopy data. | 1979 | 419739 |
| [clinical syndrome of convulsive cough of adenoviral etiology in a children's collective]. | bacteriological, viral and serological investigators were carried out in a community with 100 prescholar children (kindergarden), 34 of whom presented a clinical syndrome of whooping cough, in order to establish the bacteriologic or viral etiology of the syndrome. the etiologic role of organisms of the bordetella, b. pertussis and b. parapertussis was invalidated by the bacteriologic and serological tests. viral and serological tests, performed to demonstrate the participation of viral agents in ... | 1976 | 184515 |
| biophysical properties of virions of human adenovirus of the type 6 and its dna. | a study has been made of human adenovirus type 6 (ad 6) which belongs to the c subgroup of the nononcogenic adenoviruses. the buoyant density of the ad 6 virions in cscl gradient was 1.3545 +/- 0.0010 g/cm3. the dna content determined from the buoyant density values and direct phosphorus analysis was 11.2 +/- 0.5 and 11.5 +/- 0.5 per cent, respectively. the s20,w0 and d20,w0 values for the ad 6 virions were 795 +/- 18s and (3.255 +/- 0.035) x 10-8 cm2/s. the hydrodynamic parameters of the viral ... | 1979 | 94535 |
| integration of foreign genome fragments into cells transformed or cotransformed with fragmented adenoviral dna. | the integration of dna of highly oncogenic simian adenovirus type 7 (sa7) and non-oncogenic human adenovirus type 6 (ad6) into the genome of newborn rat kidney cells transformed by fragmented dna preparations was studied using reassociation kinetics and spot hybridization. transforming dna was fragmented with the specific endonuclease sali (sa7) and bglii (ad6). in contrast to the cell transformation by intact viral dna, transformation by fragmented dna resulted in integration into the cellular ... | 1981 | 6277738 |
| analysis of dna from human adenovirus type 6 with restriction endonucleases hindiii, bgliii and bamhi. | the genome of the type 6 human adenovirus has three restriction sites for r.bamhi, thirteen for r.hindiii and ten for r.bglii. the terminal fragments of dna cleaved by each of the enzymes have been determined by means of terminal nucleotidyl transferase and by analysis of the dna-terminal protein complex. the sequence of the cleaved fragments has been determined by partial cleavage of dna, simultaneous digestion of dna with various combinations of enzymes and secondary digestion of individual is ... | 1980 | 6243980 |
| effect of human adenovirus type 6 on the primary immune response in mice. | cflp and balb/c mice inoculated intraperitoneally with large doses of adenovirus type 6 (ad6) showed a decreased humoral immune response to sheep red blood cells (srbc) and circulating interferon was detected in their serum. the timing of infection was critical. infection of mice 3--11 days before srbc administration led to depression of the 19 s haemolytic plaque forming cell (hpfc) response in the spleen. when mice were given ad6 and srbc simultaneously on ad6 14 days before or 1 day after srb ... | 1982 | 6183955 |
| cytopathogenicity and replication of human adenovirus type 6 in cultured bovine cells. | | 1969 | 5388046 |
| epidemiology, clinical course and impact on hospitalization costs of acute diarrhea among hospitalized children in athens, greece. | the aim of this study was to describe the etiology, morbidity and hospitalization costs associated with acute diarrhea among hospitalized children in greece. during 1999, 294 hospitalized children (median age 1 y) with acute diarrhea were prospectively studied. bacterial and viral enteropathogens were detected in 100 (34%) and 37 (12.5%) patients, respectively; 17 (6%) patients had mixed infections. isolated agents included salmonella spp. (43 patients; 15%), rotavirus (32; 11%), campylobacter s ... | 2001 | 11669226 |
| acute diarrhoea in children treated in an outpatient setting in athens, greece. | to describe the epidemiology and aetiology of acute diarrhoea among children treated exclusively in an outpatient setting in greece. | 2001 | 11676518 |
| fiber-associated incomplete and complete hemagglutinins of adenovirus type 6. | | 1969 | 5369731 |
| effect of human adenoviruses on the response of chickens to sheep erythrocytes. | human adenovirus types 6, 8, and 12 were immunosuppressive in chickens. a single intravenous injection of adenoviruses markedly depressed the 19s hemolytic plaque-forming cell response in the spleen to the immunization with sheep red blood cells. hemagglutinin production was also decreased in adenovirus type 6-infected chickens. adenoviruses caused a transient immunosuppression in chickens which could be detected 2 to 3 days after the virus infection, and no depressive effect was found 16 to 20 ... | 1973 | 4570278 |
| cell cultures of bile duct epithelium and the pathogenesis of biliary atresia. | the pathogenesis of biliary atresia is unknown. the authors describe a technique for culturing extrahepatic bile duct epithelial cells of human and bovine origin in monolayer cell cultures. light-, electron microscopy and immunohistological studies prove the epithelial nature of the cultured cells. inoculation of the cells with reovirus 3 showed no destruction; adenovirus 6, herpes simplex and polio virus 1 and 2 destroyed the cells within 24 h. the cells produce a growth factor maintaining the ... | 1987 | 3582401 |
| lifelong persistent infection of hamster brain by human adenovirus type 6. | to establish an experimental persistent infection of the brain with human adenoviruses, adenovirus type 6 (ad 6) was inoculated intracerebrally into young adult hamsters. hamsters appeared languid for a few days after inoculation, but recovered rapidly. by cocultivation of tissue fragments with hela cells, ad 6 was always recovered from the brains of hamsters throughout their lives, as long as 29 months, indicating the establishment of a lifelong persistent infection. except for the first few da ... | 1988 | 3364214 |
| etiology of diarrheal infections in children of porto velho (rondonia, western amazon region, brazil). | in the present study, 470 children less than 72 months of age and presenting acute diarrhea were examined to identify associated enteropathogenic agents. viruses were the pathogens most frequently found in stools of infants with diarrhea, including 111 cases of rotavirus (23.6% of the total diarrhea cases) and 30 cases of adenovirus (6.3%). the second group was diarrheogenic escherichia coli (86 cases, 18.2%), followed by salmonella sp (44 cases, 9.3%) and shigella sp (24 cases, 5.1%). using the ... | 2006 | 16612474 |
| a proposal for naming adenovirus genome types, exemplified by adenovirus type 6. | a numerical code to denominate adenovirus (av) genome types is proposed. seven restriction endonuclease patterns are listed in alphabetical order (bamhi, bglii, bsteii, ecori, hindiii, kpni, smai); patterns deviating from those of the prototype (1) are named 2, 3 etc. depending on the chronological order of the respective isolates. thus av6/3:1231121 is a type 6 strain deviating from the prototype in three patterns, i.e. those of bglii, bsteii and kpni. from 24 av6 isolates, six were identical w ... | 1985 | 2999311 |
| evaluation of the pathogenic potential of cervid adenovirus in calves. | four 3-month-old jersey calves and three 3-month-old holstein calves were inoculated with cervid adenovirus and monitored for clinical signs until necropsied between 10 and 42 days postinoculation. the neonatal jersey calves had received colostrum, and the holstein calves were colostrum deprived. preinoculation and postinoculation serum samples were tested for antibodies to the cervid adenovirus, bovine adenovirus type 6, bovine adenovirus type 7, and goat adenovirus type 1. virus isolation was ... | 2008 | 18182505 |
| involvement of prostaglandins in immunosuppression caused by adenovirus in mice. | the effect of intraperitoneally (i.p.) inoculated human adenovirus type 6 (ad6) was tested for humoral immune response against sheep red blood cells (srbc) in normal and indomethacin-treated mice, with the aim to elucidate the mode of the virus action in immunosuppression. the results indicate that inhibition of prostaglandin synthesis slightly influences the immunosuppressive effect of the virus. it is very likely that also other mechanisms are involved in the immunosuppression observed. | 1987 | 2883861 |
| in vitro antiviral activity of a saponin from anagallis arvensis, primulaceae, against herpes simplex virus and poliovirus. | the antiviral activity of a triterpene saponin isolated from anagallis arvensis, primulaceae, was studied in vitro against several viruses including herpes simplex type 1, adenovirus type 6, vaccinia, vesicular stomatitis and poliovirus. the drug was found to inhibit the replication of herpes simplex virus type 1 and poliovirus type 2 as shown by inhibition of cytopathic effect and reduction of virus production. the action was not due to a virucidal effect but might involve inhibition of virus-h ... | 1987 | 2825589 |
| adenovirus 6 genome types: mapping of restriction site alterations on the genome. | | 1989 | 2616903 |
| clinical and microbiologic findings in lambs inoculated with pasteurella haemolytica after infection with ovine adenovirus type 6. | colostrum-deprived lambs (10 to 20 days old) were inoculated with either ovine adenovirus type 6 (oav-6; n = 6), pasteurella haemolytica type a1 (n = 6), or oav-6 followed by p haemolytica 5 days later (n = 10). another group (n = 3) served as sham-inoculated controls. lambs inoculated with oav-6 or p haemolytica developed mild and moderate respiratory tract disease of 6 and 3 days' duration, respectively. lambs inoculated with virus and bacteria developed clinical signs of respiratory tract dis ... | 1989 | 2543241 |
| the role of interferon in the adenovirus-induced augmentation of granulocyte-mediated cytotoxicity in chicken. | the effects of human adenoviruses on the granulocyte-mediated natural cytotoxicity of chicken leukocytes were investigated. a significant, but transient augmentation of granulocyte cytotoxicity was observed 24 h after virus injection, followed by a relatively long period of its suppression. a good correlation was found between the augmented cytotoxicity and interferon induction. the interferon-inducing capacity of adenovirus type 6 and type 12 in vitro similarly ran parallel with their ability t ... | 1987 | 2439443 |
| [characteristics of rat kidney cell lines transformed by the dna of human adenovirus type 6]. | the data on the transforming activity of intact dna of human adenovirus type 6 and that fragmented by restrictases bam h i (31.3% of the genome), bgl 2 (9.3% of the genome), and hind 3 (7.6% of the genome) in a primary culture of rat kidney cells are presented. the activity of the specimens varied within 1.1-2.1 foci per 1 microgram of dna. from the transformation foci 5 cell lines were derived and their properties (t-antigen production, integration of adenovirus genome, phenotypic features) wer ... | 1984 | 6324491 |
| [isolation of cell lines transformed by highly oncogenic simian adenovirus sa7 and nononcogenic human adenovirus type 6 and their dnas]. | methods for generation of cell lines transformed by highly oncogenic simian adenovirus sa7, nononcogenic human adenovirus type 6 and their dnas are described. wag rat kidney cells were used for transformation. to produce 1 focus of transformation, 1.7 x 10(6) pfu of sa7 virus is required. intact and fragmented dna of both viruses may be quite effectively used for transformation. for production of 1 transformation focus 1.2 microgram sa7 dna and 1.1 microgram type 6 adenovirus dna is required. in ... | 1983 | 6613091 |
| [escherichia coli rna-polymerase complexes with adenovirus 6 dna detected by means of electrophoresis in agar gel]. | | 1980 | 7000193 |
| [metagenomics-based detection of swine viruses]. | extreme varieties of viruses exist in the environment and animals, some of which are unknown. however, many unknown viruses are barely detected by means of conventional virus isolation and pcr assay. | 2013 | 23627112 |
| [peptide mapping of the hexon and internal protein of type 6 human and type 7 simian adenoviruses]. | hexons (polypeptide 11) and core proteins (polypeptide v) of human adenovirus type 6 and simian adenovirus type 7 were isolated using electrophoresis in polyacrylamide gel. tryptic peptide maps showed the similarity but not identify in the structure of proteins studied. this method seems to be the most suitable for comparison of relative viral proteins. | 1981 | 7248505 |
| [analysis of the structural proteins of human and simian adenoviruses]. | disk electrophoresis in polyacrylamide gel was used to study the polypeptide composition of purified virions of simian adenoviruses sa7, sv20 (h), and sv 38 as well as human adenovirus type 6. the general electrophoretic pattern of separation of structural polypeptides of simian and human adenoviruses was shown to be similar; the role of a number of components in the virion was elucidated. all the simian adenoviruses under study were found to have the following characteristic sizes of polypeptid ... | 1981 | 7257323 |
| the distribution of guanine-cytosine pairs in adenovirus dnas. | the distribution of guanine-cytosine (gc) pairs in the dna of the highly oncogenic simian adenovirus type 7 (sa7) and the non-oncogenic human adenovirus type 6 (ad6) has been studied by thermal denaturation and csc1 density-gradient centrifugation. the differential of the dna thermal denaturation curves shows the presence of pronounced peaks which indicates uneven distribution of gc pairs along the dna chains and the presence of regions with gc content from 30 to 74% in sa7 dna and from 40 to 68 ... | 1981 | 7288411 |
| [analysis of the genome of human adenovirus type 6 using restriction endonuclease r.sal i]. | | 1977 | 598279 |
| risk factors of prolonged hospital stay in children with viral severe acute respiratory infections. | severe acute lower respiratory infections (saris) are one of the major causes of morbidity and mortality in young children, especially in developing countries. the present study focused on detection of risk factors for prolonged hospital stays among children with viral saris. | 2014 | 25313605 |
| characterising the aetiology of severe acute gastroenteritis among patients visiting a hospital in qatar using real-time polymerase chain reaction. | acute gastroenteritis (age) remains a common cause of clinic visits and hospitalizations, though its aetiology has not been determined in qatar. | 2013 | 23865805 |
| [detection and typing assay of norovirus in acute hospitalizations among children less than 5 years old from 2008 to 2009 in lulong, hebei province]. | to investigate the molecular epidemiologic characteristics and genotypes of norovirus in children less than 5 years of age in lulong area from 2008 to 2009. | 2012 | 22919742 |
| clinical viral infections and temporal bone histologic studies of patients with aids. | the brain, eye, and inner ear are each protected from blood-borne infectious agents by a barrier that has some anatomic and functional differences. in patients with aids, opportunistic infections of the central nervous system and eye are frequent. little is known about the incidence of middle and inner ear infections in patients with aids, but deafness and severe vertigo are uncommon. we studied 14 homosexual men with aids, aged 28 to 55 years, for 1 to 2 years until death. no patient had deafne ... | 1995 | 7501379 |
| enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries. | this study was designed to determine if adenoviral-mediated delivery of a transgene encoding the beta 2-adrenergic receptor (beta 2-ar) to the carotid arterial wall could result in alterations in in vivo vascular function. de-endothelialized rat carotid arteries were infused in vivo with 0.1 mg/ml elastase and adenovirus [6 x 10(9) plaque forming units (pfu)] containing either the marker gene beta-galactosidase (adeno-beta-gal), dna encoding the human beta 2-ar (adeno-beta 2-ar), or no transgene ... | 1998 | 9618244 |
| pasteurella haemolytica complicated respiratory infections in sheep and goats. | respiratory infections which commonly occur in sheep and goats often result from adverse physical and physiological stress combined with viral and bacterial infections. inevitably, pasteurella haemolytica pneumonia occurs as a result of these interactions. in this review, we present recent advances in research on the complex etiology of pneumonia involving p. haemolytica. initially stress, induced by factors such as heat, overcrowding, exposure to inclement weather, poor ventilation, handling an ... | 1998 | 9689740 |
| characterization of a new adenovirus isolated from black-tailed deer in california. | an adenovirus associated with systemic and localized vascular damage was demonstrated by transmission electron microscopy and immunohistochemistry in a newly recognized epizootic hemorrhagic disease in california black-tailed deer. in this study, we describe the cultural, physicochemical and serological characteristics of a virus isolated from lung using neonatal white-tail deer lung and turbinate cell cultures. the virus had the cultural, morphological and physicochemical characteristics of mem ... | 2001 | 11504424 |
| direct antiviral effect of cycloferon (10-carboxymethyl-9-acridanone) against adenovirus type 6 in vitro. | adenoviruses represent a broad group of human pathogens that currently have no specific and safe drugs for treatment. we demonstrated direct (non ifn-mediated) antiviral activity of cycloferon (10-carboxymethyl-9-acridanone, cma), a potent interferon inducer, against adenovirus type 6 (ad6) in hep-2 cells. virus production and details of morphogenesis were studied by elisa with antibodies to the ad6 hexon protein, and transmission electron microscopy, respectively. immunoenzyme assay revealed th ... | 2003 | 12742573 |
| a fungal trna of aspergillus niger induces ifn-beta synthesis in hep-2 cells. | in this work, we evaluated the capacity of a fungal transfer rna (f-trna) from aspergillus niger to protect hep-2 cells against a viral infection, and as an inducer of ifn-beta synthesis. hep-2 cells previously incubated with f-trna, polyi:polyc, or ifn-alpha, at different concentrations for 24 h were infected with 200 pfu of adenovirus type 6 (adv-6); after 5 days, we determined cellular viability, cytopathic effect of the virus, optimal concentration necessary to inhibit the cytopathic effect, ... | 2005 | 15904674 |
| a novel adenovirus type 6 (ad6)-based hepatitis c virus vector that overcomes preexisting anti-ad5 immunity and induces potent and broad cellular immune responses in rhesus macaques. | success in resolving hepatitis c virus (hcv) infection has been correlated to vigorous, multispecific, and sustained cd8(+) t-cell response in humans and chimpanzees. the efficacy of inducing t-cell-mediated immunity by recombinant serotype 5 adenovirus vector has been proven in many animal models of infectious diseases, but its immunogenicity can be negatively influenced by preexisting immunity against the vector itself. to evaluate the less prevalent adenovirus serotype 6 (ad6) as an alternati ... | 2006 | 16439526 |
| enhanced identification of viral and atypical bacterial pathogens in lower respiratory tract samples with nucleic acid amplification tests. | the advantages of nucleic acid amplification tests (nat) over conventional methods for the detection of pathogens in lower respiratory tract samples have not been established. nat for respiratory pathogens were performed on 439 endotracheal tube (ett) and bronchoalveolar lavage (bal) samples. a potential pathogen was detected in 87 samples. of 22 samples that tested positive by conventional methods, 15 tested positive for the same pathogen by nat, 1 tested positive for a different pathogen, 2 ha ... | 2006 | 16555283 |
| modulation of the immune response induced by gene electrotransfer of a hepatitis c virus dna vaccine in nonhuman primates. | induction of multispecific, functional cd4+ and cd8+ t cells is the immunological hallmark of acute self-limiting hepatitis c virus (hcv) infection in humans. in the present study, we showed that gene electrotransfer (get) of a novel candidate dna vaccine encoding an optimized version of the nonstructural region of hcv (from ns3 to ns5b) induced substantially more potent, broad, and long-lasting cd4+ and cd8+ cellular immunity than naked dna injection in mice and in rhesus macaques as measured b ... | 2006 | 17082666 |
| serologic and hexon phylogenetic analysis of ruminant adenoviruses. | the objectives of this study were to determine the antigenic relationship among ruminant adenoviruses and determine their phylogenetic relationship based on the deduced hexon gene amino acid sequence. results of reciprocal cross-neutralization tests demonstrated antigenic relationships in either one or both directions among bovine adenovirus type 6 (badv-6), badv-7, ovine adenovirus type 7 (oadv-7), caprine adenovirus type 1 (gadv-1), and deer adenovirus (odocoileus adenovirus 1, odadv-1). no an ... | 2008 | 18340400 |
| latent species c adenoviruses in human tonsil tissues. | although species c human adenoviruses establish persistent infections, the molecular details of this lifestyle remain poorly understood. we previously reported that adenovirus dna is found in human mucosal t lymphocytes in a noninfectious form (c. t. garnett, d. erdman, w. xu, and l. r. gooding, j. virol. 76:10608-10616, 2002). in this study, human tonsil and adenoid tissues were analyzed to determine the dynamics of infection, the rate of clearance of viral dna, and the possibility of reactivat ... | 2009 | 19109384 |
| molecular characterization of adenoviral infections in cuba: report of an unusual association of species d adenoviruses with different clinical syndromes. | adenoviruses are common pathogens that are responsible for a wide variety of infectious syndromes. the objectives of this study were to identify and characterize members of different adenovirus species at the molecular level and to describe the correlation between viruses and clinical syndromes during a period of 4 years. between 2002 and 2006, 45 of 512 respiratory specimens (8%) from patients with acute respiratory tract infection tested positive for adenovirus. four adenovirus isolates from s ... | 2009 | 19280320 |
| adenovirus infections within a family cohort in iran. | adenovirus is one of the most frequent viruses associated with acute respiratory infections (ari). there is limited information of its transmission within the community. | 2009 | 19598232 |
| viral etiology of influenza-like illnesses in antananarivo, madagascar, july 2008 to june 2009. | in madagascar, despite an influenza surveillance established since 1978, little is known about the etiology and prevalence of viruses other than influenza causing influenza-like illnesses (ilis). | 2011 | 21390235 |
| distinguishing characteristics between pandemic 2009-2010 influenza a (h1n1) and other viruses in patients hospitalized with respiratory illness. | differences in clinical presentation and outcomes among patients infected with pandemic 2009 influenza a h1n1 (ph1n1) compared to other respiratory viruses have not been fully elucidated. | 2011 | 21949746 |
| novel adenovirus-based vaccines induce broad and sustained t cell responses to hcv in man. | currently, no vaccine exists for hepatitis c virus (hcv), a major pathogen thought to infect 170 million people globally. many studies suggest that host t cell responses are critical for spontaneous resolution of disease, and preclinical studies have indicated a requirement for t cells in protection against challenge. we aimed to elicit hcv-specific t cells with the potential for protection using a recombinant adenoviral vector strategy in a phase 1 study of healthy human volunteers. two adenovi ... | 2012 | 22218690 |
| [mixed infections in children with mycoplasma pneumoniae pneumonia]. | to investigate the incidence and clinical features of mixed infections in children with mycoplasma pneumoniae (mp) pneumonia. | 2012 | 22801206 |
| activated cd4+ccr5+ t cells in the rectum predict increased siv acquisition in sivgag/tat-vaccinated rhesus macaques. | an effective t-cell-based aids vaccine should induce strong hiv-specific cd8(+) t cells in mucosal tissues without increasing the availability of target cells for the virus. here, we evaluated five immunization strategies that include human adenovirus-5 (adhu5), chimpanzee adenovirus-6 (adc6) or -7 (adc7), vaccinia virus (vv), and dna given by electroporation (dna/ep), all expressing simian immunodeficiency virus group specific antigen/transactivator of transcription (siv(mac239gag/tat)). five g ... | 2015 | 25550504 |
| detection of rotavirus and other enteropathogens in children hospitalized with acute gastroenteritis in havana, cuba. | the aim of the study was to diagnose infections with rotavirus and other enteric pathogens in children under five years old with acute gastroenteritis and to identify the most common epidemiological and clinical characteristics of these pathogens. the study was conducted using 110 stool samples from the same number of children under five years old who were inpatients at three paediatric hospitals in havana, cuba, between october and december 2011. the samples were tested for rotavirus and other ... | 2015 | 26026957 |
| postinfectious functional gastrointestinal disorders in children: a multicenter prospective study. | to prospectively investigate the occurrence of postinfectious functional gastrointestinal disorders (fgids), diagnosed according to the rome iii criteria, in children with acute diarrhea of different infectious etiology. | 2015 | 25661403 |
| gene therapy for hemophilia b: host immunosuppression prolongs the therapeutic effect of adenovirus-mediated factor ix expression. | hemophilia b is caused by a deficiency of blood clotting factor ix (fix). previous studies have shown that the delivery of a recombinant adenoviral vector expressing canine fix (cfix) resulted in a complete correction of hemophilia b in fix-deficient dogs, but that cfix expression decreased to only about 1-2% of normal levels 3 weeks after treatment. in the present study, therapeutic levels of cfix expression capable of producing a partial correction of hemophilia b were maintained for at least ... | 1995 | 7578416 |
| the hexon genes of adenoviruses of subgenus c: comparison of the variable regions. | we report on a 1402-base pair long dna sequence, encoding for the variable region and parts of the flanking conserved regions of the human adenovirus type 1 (av1) hexon, and a dna sequence comprising 1396 base pairs, encoding for the corresponding regions of the human adenovirus type 6 (av6) hexon. av1 and av6, together with av2 and av5, belong to subgenus c. comparison of the predicted amino acid sequences of av1 and av6 with those of av2 and av5 revealed that the variable hexon region could be ... | 1993 | 8511397 |
| community respiratory virus infections among hospitalized adult bone marrow transplant recipients. | from 1 november 1992 through 1 may 1993 and from 1 november 1993 through 1 may 1994, we conducted a prospective surveillance study at the university of texas m.d. anderson cancer center (houston) to evaluate the role of community respiratory virus infections in hospitalized adult bone marrow transplant (bmt) recipients, respiratory secretions were obtained from all adult bmt recipients with acute respiratory illnesses. during these two winters, a community respiratory virus was isolated from 37 ... | 1996 | 8722930 |
| comap: a comigrating analysis program for estimating the relationship of adenoviruses on the genome level. | the computer program comap is described that enables one to evaluate the relationship among adenovirus 6 strains by comigration analysis with regard to the genome. the required data were obtained by restriction analysis with several enzymes. the program is also important for identifying further adenovirus strains by dna restriction analysis and to compare new restriction fragment patterns with stored data of known adenovirus strains. we believe that in this manner the dna restriction analysis wi ... | 1986 | 3003682 |
| [adenovirus 6 as the cause of epidemics]. | | 1969 | 4311644 |
| the prevalence of neutralising antibodies to chimpanzee adenovirus type 6 and type 7 in healthy adult volunteers, patients with chronic hepatitis b and patients with primary hepatocellular carcinoma in china. | the presence of neutralising antibodies (nabs) against adenovirus in the population is a major hurdle preventing the effective use of replication-defective adenoviruses (ads) as candidates for gene therapy and vaccine vectors for many diseases. only a few studies have described the epidemiology of pre-existing immunity to chimpanzee ads in china. to assess the prevalence of nabs to chimpanzee adenovirus serotypes 6 and 7 (adc6 and adc7), we enrolled 998 healthy participants from five regions in ... | 2014 | 24057756 |
| microrna regulation of oncolytic adenovirus 6 for selective treatment of castration-resistant prostate cancer. | almost all patients with advanced prostate cancer progress to castration-resistant stage with limited treatment options. oncolytic adenoviruses have been actively pursued as potential agents for cancer treatment. virtually all clinical trials on oncolytic adenovirus are based on serotype 5. however, viral replication in hepatocytes induces severe liver toxicity and limits its systemic administration for metastatic disease. moreover, rapid clearance of viral particles injected intravenously furth ... | 2012 | 22914437 |
| recombinant human nerve growth factor (rhngf-β) gene transfer promotes regeneration of crush-injured mental nerve in rats. | the aim of this study was to evaluate whether the recombinant human nerve growth factor (rhngf-β) gene transfer at a crush-injured sensory nerve can enhance nerve regeneration. | 2012 | 22669154 |