| cell-mediated immunity to mouse adenovirus infection. macrophage migration inhibition test. | cell-mediated immunity (cmi) to mouse adenovirus (m-ad) infection was studied by macrophage migration inhibition test (mmi) as one of in vitro correlates of cmi. both direct and indirect tests showed clearly that migration of packed peritoneal exudate cells (pec) (immune mouse or nonimmune guinea pig) was remarkably inhibited; mif was produced by interactions between immune pec and infected cell extracts and between immune spleen cells and infected cells or their extracts. the antigen(s) respons ... | 1978 | 213697 |
| early region 4 sequence and biological comparison of two isolates of mouse adenovirus type 1. | the dna sequence of 88-100 map units of mouse adenovirus type 1 (mav-1) was determined. one translational open reading frame showed 48% sequence similarity to a human adenovirus type 2 early region 4 protein. based on the protein similarity, genome location, and transcriptional polarity, we concluded that this region of mav-1 corresponds to early region 4. a 241-bp sequence consisting of 10 imperfect direct repeats with sequence similarity to minisatellite dna was found in this region. two virus ... | 1991 | 1845825 |
| sequence of mouse adenovirus type 1 dna encoding the amino terminus of protein iva2. | | 1990 | 2374728 |
| immunomodulation by bordetella pertussis: antiviral effects. | treatment of mice by intraperitoneal inoculation of pertussis vaccine or lipopolysaccharide extracted from b. pertussis will effect resistance to rabies virus, encephalomyocarditis virus, semliki forest virus, and herpes simplex virus. our previous observations indicated that treatment of c3h/hen (+/nu) and bdf1 mice with pertussis vaccine injected i.p. five days prior to a mouse adenovirus lethal dose i.p. challenge elicited resistance to clinical disease and death. susceptibility returned to a ... | 1985 | 2872109 |
| seromonitoring in small laboratory animal colonies. a five year survey: 1984-1988. | from 1984 to 1988 one thousand serologic investigations of laboratory animal colonies originating from 10 different european countries were performed. the most prevalent infections in mouse stocks were caused by mouse hepatitis virus (mhv), minute virus of mice (mvm), theiler's encephalomyelitis virus (temv), reovirus type 3 (reo3), sendaivirus, and pneumonia virus of mice (pvm). in mice no infections with lymphocytic choriomeningitis virus (lcm), polyomavirus, mouse adenovirus, and k-virus were ... | 1990 | 2321435 |
| biologically active proviral clone of myeloblastosis-associated virus type 1: implications for the genesis of avian myeloblastosis virus. | a biologically active myeloblastosis-associated virus (mav) provirus was cloned from a bacteriophage recombinant library constructed from leukemic chicken myeloblast dna. the restriction endonuclease map of this clone was consistent with that of a type 1 mav (mav-1). interference assays of virus recovered from cultured chicken embryo fibroblasts after dna transfection established that the provirus was infectious and confirmed that it belonged to avian retrovirus subgroup a (type 1). antipeptide ... | 1985 | 2993653 |
| binding properties of avian retroviral proteins. ii. binding of protein aslv nc(p12) to viral rna and proviral dna. | binding of the major avian retroviral nucleocapsid protein aslv nc(p12) to the mav-1 (myeloblastosis-associated virus) proviral dsdna and viral ssrna was analysed using electron microscopy. specificity of the binding was estimated by special computer programs. the nc(p12) protein bound to mav-1 proviral dsdna (clone pat153--mav-1), but specificity of this binding was not found by computer evaluation. nc(p12) also bound to nondenatured 70s viral rna at a rate of 25 +/- 3 molecules per rna molecul ... | 1990 | 2160894 |
| acceleration of scrapie disease in mice by an adenovirus. | coinfected mice were examined for a possible interaction between the scrapie agent and an adenovirus. a low titer (10(2) tcd50) of mouse adenovirus (madv) caused a significant acceleration of clinical signs of scrapie in mice infected 128 days previously with scrapie. in this experiment, the coinfected mice died 19 days earlier than mice infected with scrapie alone. when a higher titer of madv (10(4)-10(5) pfu) was used, a more drastic acceleration of scrapie disease was seen in mice infected 85 ... | 1986 | 3013796 |
| naturally acquired enteric adenovirus infection in syrian hamsters (mesocricetus auratus). | intranuclear inclusions indicative of adenovirus infection were detected microscopically in formalin-fixed intestinal tissues from preweanling syrian hamsters. the amphophilic intranuclear inclusion bodies were observed in ileal enterocytes from 16-to 24-day-old hamsters. electron microscopy revealed large numbers of 72 +/- 3-nm viral particles typical of adenoviridae in enterocytic nuclei. serum antibodies reacted with mouse adenovirus strains k87 and, to a lesser extent, fl, by indirect fluore ... | 1990 | 2154145 |
| transcription mapping of mouse adenovirus type 1 early region 3. | early region 3 (e3) of mouse adenovirus type 1 was analyzed using s1 nuclease protection and primer extension assays, cdna sequencing, and genomic sequencing. we present the genomic sequence from 79 to 83 map units of the viral genome, the precise ends and splice sites of the e3 mrnas, and the predicted protein sequence encoded by the mrnas. three major classes of early mrnas were identified; all were approximately 1 kb long, consisted of three exons, and shared 5' and 3' ends. the three classes ... | 1990 | 2137954 |
| factors influencing susceptibility of laboratory rodents to infection with mouse adenovirus strains k 87 and fl. brief report. | weanling outbred mice were more than 500 times less susceptible to orally administered mouse adenovirus (madv) strain k 87 than to madv-fl. mouse susceptibility to madv-k 87 was age-dependent but not obviously host genotype-dependent. infant f 344 rats were not susceptible to infection with either madv strain. | 1987 | 3036043 |
| identification of mouse adenovirus type 1 early region 1: dna sequence and a conserved transactivating function. | the left end of the genome of mouse adenovirus type 1 (also known as strain fl) was characterized by determination of the dna sequence, amino acid similarities with early region proteins of primate adenoviruses, and a functional assay. several specific dna sequence features were similar to those found in human adenoviruses, and open reading frames from this region could encode proteins similar to human adenovirus early region 1a and early region 1b proteins. dnas from this region were tested in ... | 1988 | 3172335 |
| primary structure of the murine adenovirus type 1 proteinase. | the dna sequence of an open reading frame (orf) corresponding to the murine adenovirus type 1 (mav1) proteinase gene was determined. 1162 base pairs were sequenced from the downstream end of the smai-d mav1 genomic fragment. the sequence defines the 204 amino acid proteinase, which apparently does not possess the usual l3 polyadenylation signal, but instead the sequence aaataa. this gene is followed by a 147 amino acid c-terminal portion of the dna-binding protein, encoded by the complementary s ... | 1992 | 1536888 |
| transcription mapping of mouse adenovirus type 1 early region 4. | early region 4 (e4) of mouse adenovirus type 1 was analyzed by northern blotting, cdna sequencing, and s1 nuclease protection and primer extension assays. the transcription map of this region was dissimilar to the consensus human adenovirus e4 transcription map in which all transcripts have identical 5' and 3'-terminal sequences. seven classes of mouse adenovirus type 1 mrnas were identified; all shared the same 3' end. three classes of unspliced mrnas differed at their 5' start sites, two class ... | 1992 | 1388309 |
| adenovirus endocarditis in mice. | viral endocarditis developed in 24 percent of 50 newborn mice 6 to 8 days after intraperitoneal inoculation with murine adenovirus. typical adenovirus intranuclear inclusions were seen in heart-valve lesions, and high titers of virus were recovered from heart tissue. furthermore, adenovirions were directly visualized by electron microscopy within endothelial cells and fibroblasts of the heart valves. | 1967 | 4290792 |
| intestinal resistance in the experimental enteric infection of mice with a mouse adenovirus. i. growth of the virus and appearance of a neutralizing substance in the intestinal tract. | | 1970 | 4319728 |
| intestinal resistance in the experimental enteric infection of mice with a mouse adenovirus. ii. determination of the neutralizing substance in the intestinal tract as an iga antibody. | | 1971 | 4334551 |
| pathogenesis of experimentally produced mouse adenovirus infection in mice. | | 1972 | 4336084 |
| [effect of neonatal thymectomy on the experimental enteric infection of germfree mice with a mouse adenovirus (author's transl)]. | | 1973 | 4356441 |
| [effect of antilymphocyte serum on the time course of experimental enteric infection of mice with a mouse adenovirus (author's transl)]. | | 1973 | 4356442 |
| experimental infection with mouse adenovirus in adult mice. | | 1973 | 4356771 |
| experimental adenovirus infection of the mouse adrenal gland. ii. electron microscopic observations. | a strain of mouse adenovirus, found to have a striking tropism for the weanling mouse adrenal gland, enabled electron microscopic examination of adrenals in various stages of infection. nucleolar hypertrophy and the successive formation of three types of inclusion bodies in association with nucleoli preceded virion production. angular crystals of virions formed in the affected nuclei. virus was released by lysis of nuclear membranes; rapid degeneration of cytoplasmic organelles followed. rupture ... | 1974 | 4362917 |
| intestinal resistance in the experimental enteric infection of mice with a mouse adenovirus. 3. suppressive effect of cyclophosphamide on the establishment and duration of the intestinal resistance. | | 1973 | 4365101 |
| serological classification of two mouse adenoviruses. | | 1974 | 4474867 |
| fluctuation of antiviral resistance in the intestinal tracts of nude mice infected with a mouse adenovirus. | oral administration of adenovirus strain k87 to balb/c nude mice resulted in viral proliferation in the intestinal tract up to around week 6 at which point replication was suppressed. in other words, the host acquired resistance. however, this resistance was temporary and the viral infection persisted over a long period with repeated periods of proliferation and resistance. that the appearance of this resistance is the result of infecting mice with the virus and is not due to age difference per ... | 1984 | 6090870 |
| [serological study of the incidence of murine viruses in a population of small wild rodents (microtus pennsylvanicus ord, 1815)]. | the results of a serological survey of a free-living population of meadow voles (microtus pennsylvanicus) in pinawa, manitoba (canada) showed that these animals possessed antibodies to six of the eleven viruses tested for, namely: reovirus type 3, murine encephalomyelitis agent, ectromelia virus, murine adenovirus, murine hepatitis virus and lymphocytic choriomeningitis virus. the significant increase in the number of individuals possessing specific antibodies suggests that these viruses, or rel ... | 1992 | 1339064 |
| proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas. | histological and anatomopathological studies performed on 152 independent myeloblastosis-associated virus type 1 (mav1)-induced nephroblastomas allowed us to precisely define the chronology of tumor development in chickens. three tumors representing increasing developmental stages were used to construct genomic libraries and to study both the state of proviral genomes and the sites of mav1 integration in genomic dna. we established that increasing levels of proviral rearrangement, eventually lea ... | 1992 | 1309586 |
| alignment of the restriction map of mouse adenovirus fl with that of human adenovirus 2. | | 1979 | 573019 |
| mouse adenovirus: growth of plaque-purified fl virus in cell lines and characterization of viral dna. | | 1977 | 561475 |
| biological and biophysical characteristics of mouse adenovirus, strain fl. | mouse adenovirus, strain fl (mav), is best propagated in primary rather than secondary cultures of mouse kidney cells. virus release from the cells into the medium is fairly efficient; the average yield per cell is about 1000 tcid50. morphological and other biophysical characteristics are those of a typical adenovirus: the icosahedral shell with a diameter of 74 nm, fiber projections of 29 nm length, its localization inside the infected kidney cells, a buoyant density in csc1 of 1.34 g/ml, inhib ... | 1977 | 560839 |
| nature and specificity of effector cells in cell-mediated cytolysis of mouse adenovirus-infected cells. | the type of effector cells in immune spleen cells (isc) responsible for cell-mediated cytolysis of mouse adenovirus-infected cells was characterized. when isc were pretreated with anti-mouse thymocyte or anti-thy1.2 serum and complement, their cytolytic activity assayed by the (51)cr release test was completely abolished, whereas it was not significantly reduced either when isc were pretreated with anti-mouse immunoglobulin serum and complement or after isc were kept standing at 37 degrees c for ... | 1978 | 310422 |
| effects of viral exposure of the two-cell mouse embryo on cleavage and blastocyst formation in vitro. | the effect of viral exposure of two-cell mouse embryos on their capacity to undergo subsequent cleavage and blastocyst formation in vitro was determined. exposure to coxsackie viruses b-4 and b-6, reovirus type 2, influenza virus type a, mouse cytomegalovirus, adenovirus type 5, and mouse adenovirus resulted in statistically significant inhibition of blastocyst formation. development in vitro was unaffected by exposure to echo virus type 11, attenuated poliomyelitis virus type 2, parainfluenza v ... | 1979 | 225719 |
| properties of adeno-associated virus (type 1) replicated in rodent cells by murine adenovirus. | we report for the first time the replication of infectious adeno-associated virus type 1 (aav-1) in rodent cells [primary mouse kidney (pmk) and mouse l929 cells] using murine adenovirus (mav) as a helper virus and also the production of aav-i virus antigen by herpes simplex virus type i (hsv-i) with its temperature-sensitive mutant ts 200 in mouse neuroblastoma (nb) cells. the infectious aav virions produced by mav on l cells had a buoyant density of 1.41 2ml in caesium chloride gradients. | 1980 | 6257836 |
| cell-mediated immunity assayed by 51cr release test in mice infected with mouse adenovirus. | immune spleen cells (isc) from mice immunized with a sublethal dose of mouse adenovirus (m-ad) were shown by the 51cr release test to be cytotoxic to target mouse embryonic cells or lymphoid cells infected with m-ad. the number of isc required for release of statistically significant amounts of 51cr from target cells varied from one sample to another, ranging from 5 to greater than or equal to 30 isc per target cell. when 24-h-infected mouse embryonic cells were used as targets, the release of 5 ... | 1978 | 208968 |
| mechanism of induction of cell-mediated immunity to virus infections: in vitro inhibition of intracellular multiplication of mouse adenovirus by immune spleen cells. | mice were protected from lethal infection with mouse adenovirus (m-ad) by adoptive transfer of immune spleen cells (isc) that were prepared from mice immunized with m-ad and not protected by sonicated isc. however, a similar extent of protection was also observed by passive immunization with anti-m-ad serum. in contrast, by in vitro experiments isc were shown to be able to interrupt intracellular multiplication of m-ad, whereas sonicated isc, unimmunized mouse spleen cells, or anti-m-ad serum we ... | 1975 | 164414 |
| evolutionary variants of mouse adenovirus containing cellular dna sequences. | | 1982 | 6278728 |
| defective parvoviruses acquired via the transplacental route protect mice against lethal adenovirus infection. | adeno-associated virus type 1 (aav-1) interfered with the replication of its murine adenovirus (mav) helper in primary mouse kidney cells and in 1-day-old icr mice. mice carrying aav-1 acquired via the transplacental route were protected against lethal infection with mav. the replication of aav-1 in these mice could be triggered by multiple challenges with mav, and antibodies to aav-1 were subsequently detected. | 1982 | 6286489 |
| serological survey of laboratory rodents for infection with sendai virus, mouse hepatitis virus, reovirus type 3 and mouse adenovirus. | | 1982 | 6298492 |
| a monoclonal antibody with specificity for leukemic cells transformed by defective avian leukemia viruses. | mouse anti-chicken monoclonal antibodies were raised against an avian myeloblastosis virus (amv)-transformed myeloblastic leukemic cell line. one monoclonal antibody, s1-37 (igg2a), reacted with producer and nonproducer myeloblastic leukemia cell lines transformed by amv and by e-26 virus, but it did not react with chicken fibroblasts infected with rav-2, mav-2, mav-1, or rav-7. s1-37 also did not react with normal chicken hemopoietic cells, except for yolk sack macrophages and a small populatio ... | 1982 | 6302112 |
| transformation of brown leghorn chicken embryo fibroblasts by avian myeloblastosis virus proviral dna. | brown leghorn chicken embryo fibroblasts were transfected with a mixture of avian myeloblastosis virus (amv) and myeloblastosis-associated virus type 1 (mav1) proviral dna purified from lambda-charon 4a recombinant clones. a transformed cell line (t1am) able to grow without anchorage in semisolid medium was obtained. the presence of both proviral amv and mav sequences was detected in t1am dna by hybridization with v-myb- and mav1-specific probes. altered amv and mav1 proviral genomes were found ... | 1985 | 2989555 |
| resistance to adenovirus infection after administration of bordetella pertussis vaccine in mice. | treatment of mice with bordetella pertussis vaccine rendered mice resistant to mouse adenovirus infection. the resistant state took at least 5 days to develop, and susceptibility returned to a portion of the test population 35 days after treatment. transient resistance developed in congenitally athymic mice also. treatment with a dose of 25 micrograms (dry weight) of b. pertussis vaccine protected approximately 50% of the test population. vaccines prepared from several different strains of b. pe ... | 1985 | 2982736 |
| specificity of avian leukosis virus-induced hyperlipidemia. | rous-associated virus 7 (rav-7) is a subgroup c avian leukosis virus which does not transform cells in vitro or carry an oncogene. when injected into 1-day-old hatched chicks, rav-7 causes a low incidence of lymphoid leukosis after a latent period of several months. in contrast, infection of 10-day-old chicken embryos with rav-7 leads to a disease syndrome characterized by stunting, obesity, atrophy of the bursa and the thymus, high triglyceride and cholesterol levels, reduced thyroxine levels, ... | 1984 | 6323732 |
| avian nephroblastomas induced by a retrovirus (mav-2) lacking oncogene. i. construction of mav-1 and mav-2 proviral restriction maps and preparation of specific proviral molecular subclones. | a 9.8 kb dna fragment containing the complete mav-1 provirus was recloned from the recombinant bacteriophage lambda 311411 (perbal et al., 1985) into the plasmid pat153. a detailed and precise restriction map of the obtained clone (pat-mav-1) was constructed. from compilation of this map and the known sequence of a variable portion of the mav-2 env gene was a restriction map of mav-2 deduced. knowledge of the detailed pat-mav-1 map facilitated the preparation of five specific proviral subclones: ... | 1988 | 2849567 |
| a size analysis of the adenovirus replicon. | the linear double-stranded genome of adenovirus dna replicates semiconservatively from two origins of replication at either of the two molecular ends. using an in vitro replication system which is able to initiate de novo dna synthesis we have mapped the origin of dna replication within the terminal 19 bp of the viral genome. our conclusions are based on the use of different natural dna templates, i.e., adenovirus type 2 and mouse adenovirus fl dna. in addition, we have employed linearized plasm ... | 1984 | 6714222 |
| genotypic differences between the mouse adenovirus strains fl and k87. | restriction endonuclease analysis was used to compare the genome of mouse adenovirus (mad) strains fl and k87. large differences were found between the kpn i, paer7, pvu i, sal i and sma i restriction profiles of the prototype strains. mad-fl and mad-k87 thus represent two distinct species of mouse adenovirus. | 1988 | 2832207 |
| genome typing of mouse adenoviruses. | restriction endonuclease cleavage site analysis was used to differentiate between mouse adenovirus (mav) types 1 and 2 strains. viral dna of suitable purity and quantity for multiple enzymatic digestions was obtained from cloned cmt-93 mouse tumor cells infected with each type of mav. clear differences between the mav-1 (fl) and mav-2 (k87) genomes were observed after cleavage with restriction enzymes such as bglii, ecori, and paer7. fast electrophoresis of dna fragments in miniature agarose sla ... | 1988 | 2830299 |
| association of mouse adenovirus-induced cell surface antigen(s) with histocompatibility antigens. | | 1980 | 6997695 |
| induction of nephroblastoma by myeloblastosis-associated virus type 1: state of proviral dnas in tumor cells. | myeloblastosis-associated virus type 1 (mav1) derived from a molecular clone of infectious proviral dna (b. perbal, j. s. lipsick, j. svoboda, r. f. silva, and m. a. baluda, j. virol. 56:240-244, 1985) was shown to specifically induce nephroblastoma in chickens and therefore belongs to the mav-n class. we show that nephroblastomas are polyclonal tumors containing rearranged proviral genomes. rearrangements occur preferentially in the gag-pol region of the mav1 proviral genome, and similar rearra ... | 1989 | 2564440 |
| genome organization of mouse adenovirus type 1 early region 1: a novel transcription map. | mouse adenovirus type 1 (mav-1) genomic dna from 8.9 to 13.7 map units was sequenced and the early region 1 (e1) transcription map was determined by s1 nuclease, primer extension, and northern analyses, and cdna sequencing. the e1 transcription map of mav-1 had marked dissimilarities from the conserved transcription maps of primate adenovirus e1s. one major e1a and two e1b mrnas were identified in overlapping transcription units. the single e1a mrna was composed of three exons; the last exon was ... | 1989 | 2543128 |
| the mouse adenovirus type 1 contains an unusual e3 region. | since the e3 region of human adenoviruses codes for a series of proteins that are probably involved in viral pathogenesis, the nucleotide sequence for a 3.6-kilobase dna fragment in the corresponding region (map units 77 through 89) of the mouse adenovirus type 1 genome has been determined. analysis of the sequence revealed that the genes for the fiber and for the precursor to the hexon-associated protein, pviii, that usually flank the e3 region, are well conserved. however, many of the open rea ... | 1989 | 2531236 |
| analysis of antiviral resistance in the intestinal tracts of nude mice infected with a mouse adenovirus. | upon intestinal infection of heterozygous (nu/+) mice with mouse adenovirus, antiviral resistance can be seen in the form of negative-recovery of virus from feces 2-3 wks post infection. on the other hand, in similar infections in balb/c nude (nu/nu) mice, the antiviral resistance is manifested as negative-recovery of virus from feces at a later stage, i.e., at around 6 wks post infection. this resistance was not accompanied by rises in interferon titer, rises in natural killer (nk) cell activit ... | 1987 | 2453086 |
| characterization of an 11k protein produced by early region 3 of mouse adenovirus type 1. | early region 3 (e3) of mouse adenovirus type 1 produces three mrnas that can encode three proteins with unique carboxy-terminal exons. a bacterial fusion protein encoding the unique terminus of one the three predicted proteins was used to generate antiserum in rabbits. this antiserum detected a 14k protein on a western blot of infected cell lysates. immunoprecipitation and endoglycosidase h digestion revealed that the 14k protein was a glycoprotein with a core molecular weight of 11k, and we are ... | 1995 | 7747418 |
| mouse polyoma virus and adenovirus replication in mouse cells temperature-sensitive in dna synthesis. | mouse adenovirus multiplies, apparently without impediment, in temperature-inactivated ts a1s9, tsc1 and ts2 mouse fibroblasts. thus, the dna of mouse adenovirus can replicate in the absence of functional dna topoisomerase ii, a dna-chain-elongation factor, and a protein required for traverse of the g1/s interface, respectively, encoded in the ts a1s9, tsc1 and ts2 genetic loci. these results are compared with those obtained with polyoma virus. | 1985 | 2999031 |
| comparative biological characterization of mouse adenovirus strains fl and k 87 and seroprevalence in laboratory rodents. | the growth, stability and seroprevalence in laboratory rodents of the two known strains of mouse adenovirus were compared. the fl strain of mouse adenovirus grew in both l 929 murine fibroblasts and in cmt-93 murine rectal carcinoma cells, whereas the k 87 strain grew only in cmt-93 cells. the bulk of the fl progeny virus was released from the host cells. k 87 virus was largely cell-associated. both virus strains were stable at 37 degrees c in liquid medium. the k 87 strain was completely inacti ... | 1986 | 3022678 |
| [a comparison of two antigen strains of each of mouse hepatitis virus and mouse adenovirus for detection of complement fixation antibody in mouse and rat sera]. | detection rates of complement fixation antibodies in mice and rats were compared between two antigen strains of each of mouse hepatitis virus (mhv) and mouse adenovirus (mav). among 66 and 47 naturally infected mhv-positive sera of mice (18 facilities) and rats (16 facilities) respectively, 17 mouse and 21 rat sera reacted with both nu-67 and mhv-2 strains, but 49 mouse and 25 rat sera were positive to nu-67 strain alone. only one rat serum reacted with mhv-2 strain alone. in comparison with k87 ... | 1986 | 3026815 |
| introduction and expression of the bacterial paer7 methylase gene in mammalian cells. | an approach is devised for studying the role of dna methylation in eukaryotic gene expression. the approach is based on the expression of site-specific bacterial methylase genes in animal cells. a model system using the cloned paer7 (an isoschizomer of xho i) methylase gene was constructed to test the feasibility of this approach. expression plasmids for the paer7 methylase gene were introduced into mouse ltk- cells by cotransfection with the cloned chicken thymidine kinase (tk) gene. several of ... | 1986 | 3463994 |
| pathogenic potential of myeloblastosis-associated virus: implication of env proteins for osteopetrosis induction. | to identify the nucleotide sequences responsible for the tumorigenic specificity of myeloblastosis-associated virus (mav) we have established the complete nucleotide sequences of three infectious clones inducing either both osteopetrosis and nephroblastoma [mav2(o)/2 and mav2(o)p9] or only nephroblastoma [mav1(n)], and compared their biological properties in the same chicken host strain. the mav2(o)p9 originally described as a type 2 strain was found to carry a hybrid env gene containing sequenc ... | 1993 | 8393249 |
| murine adenovirus infection of scid mice induces hepatic lesions that resemble human reye syndrome. | murine adenovirus type 1 (mav-1) infection of cb-17 scid mice (which are homozygous for the severe combined immunodeficiency mutation) induces hepatic histopathologic and ultrastructural features that are strikingly similar to human reye syndrome. gross pathologic examination of mav-1-infected mice revealed only pale yellow liver tissue. histopathologic studies of tissue from mav-1-infected mice revealed diffuse hepatic injury manifested by microvesicular fatty degenerative changes of hepatocyte ... | 1991 | 1852004 |
| serological relationship between mouse adenovirus strains fl and k87. | three-week-old outbred mice were inoculated intraperitoneally or orally and intranasally with the fl or k87 strains of mouse adenovirus and bled at intervals after infection. serum was tested by both the complement fixation and indirect immunofluorescence tests for reactivity with either virus antigen. a unilateral relationship was detected between fl and k87 strains. serum from mice given the fl strain of virus reacted in both tests with fl and k87 antigens. serum from mice given the k87 strain ... | 1987 | 3586604 |
| genetic structure of avian myeloblastosis virus, released from transformed myeloblasts as a defective virus particle. | chicken myeloblasts transformed by avian myeloblastosis virus (amv) in the absence of nondefective helper virus (termed nonproducer cells) were found to release a defective virus particle (dvp) that contains avian tumor viral gag proteins but lacks envelope glycoprotein and a dna polymerase. nonproducer cells contain a pr76 gag precursor protein and also a protein that is indistinguishable from the pr180 gag-pol protein of nondefective viruses. the rna of the dvp is 7.5 kilobases (kb) long and i ... | 1980 | 6159639 |
| sequence of the mouse adenovirus type-1 dna encoding the 100-kda, 33-kda and dna-binding proteins. | the genomic nucleotide sequence for the region of 66 to 77 map units (m.u.) of mouse adenovirus type 1 (mav-1) was determined and predicted to encode proteins homologous to the human adenovirus (ad) 100-kda, 33kda and dna-binding proteins (dbp). the putative mav-1 100-kda protein has 65-70% amino-acid similarity to 100-kda proteins from five different human ad serotypes. the mrna for the putative 33-kda protein is internally spliced within the coding sequence, as are its human ad counterparts [o ... | 1996 | 8654941 |
| characterization of avian myeloblastosis-associated virus dna intermediates. | the major species of unintegrated linear viral dna identified in chicken embryonic fibroblasts infected with either the avian myeloblastosis-associated viruses (mav-1, mav-2) or the standard avian myeloblastosis virus complex (amv-s) has a mass of 5.3 x 10(6) daltons. an additional minor dna component observed only in amv-s-infected cells has a mass of 4.9 x 10(6) daltons. the unintegrated linear viral dnas and integrated proviruses of mav-1 and mav-2 have been analyzed by digestion with the res ... | 1980 | 6246269 |
| age and susceptibility of swiss mice for mouse adenovirus, strain fl. | nmri mice of different ages (24 hours, 10 to 12 days old, adults) were inoculated intraperitoneally with varying doses of mouse adenovirus. the susceptibility to disease was high in newborn mice (1 ld50 equalled 7 tcid50, as measured in mouse kidney cell cultures), medium in 10 days' old mice and almost nil in adult animals. the survival time was not greatly influenced by the virus dose. the susceptibility to infection is greatest in adults and lowest in 10 day old mice; these show a susceptibil ... | 1980 | 6249244 |
| lack of effect of mouse adenovirus type 1 infection on cell surface expression of major histocompatibility complex class i antigens. | it has been proposed that adenoviruses establish and maintain persistent infections by reducing the class i major histocompatibility complex-associated presentation of viral antigens to cytotoxic t lymphocytes, leading to ineffective cell-mediated immunity and impaired clearance of infected cells (w.s.m. wold and l. r. gooding, virology 184:1-8, 1991). early region 3 of human adenovirus types 2 and 5 encodes a 19-kda glycoprotein that associates with the class i major histocompatibility complex ... | 1996 | 8764061 |
| identification of the avian myeloblastosis virus genome. i. identification of restriction endonuclease fragments associated with acute myeloblastic leukemia. | the proviral dna of chicken peripheral blood leukemic myeloblasts was analyzed by restriction endonuclease digestion and southern blotting. two restriction endonuclease-generated fragments, an ecori 2.2-megadalton (md) and a hindiii 2.6-md fragment, were present upon enzyme cleavage of all leukemic myeloblast dna preparations in addition to endogenous or helper-specific fragments. neither of these fragments was derived from viral dna of the two known myeloblastosis-associated viruses (mav-1 and ... | 1980 | 6253658 |
| identification of the avian myeloblastosis virus genome. ii. restriction endonuclease analysis of dna from lambda proviral recombinants and leukemic myeoblast clones. | two lambda proviral dna recombinants were characterized with a number of restriction endonucleases. one recombinant contained a complete presumptive avian myeloblastosis virus (amv) provirus flanked by cellular sequences on either side, and the second recombinant contained 85% of a myeloblastosis-associated virus type 1 (mav-1)-like provirus with cellular sequences adjacent to the 5' end of the provirus. comparing the restriction maps for the proviral dnas contained in each lambda hybrid showed ... | 1980 | 6253659 |
| cellular sequences are present in the presumptive avian myeloblastosis virus genome. | ecori restriction endonuclease fragments from a lambda proviral dna hybrid containing the entire presumptive avian myeloblastosis virus (amv) provirus, and from a lambda proviral hybrid containing a partial myeloblastosis-associated virus type 1 (mav-1)-like provirus were compared by heteroduplex analysis. the cloned presumptive amv provirus was also analyzed by electron microscopy, using r-loop formation with purified 35s rna isolated from virions of the standard amv complex. the results indica ... | 1980 | 6254063 |
| completion of the dna sequence of mouse adenovirus type 1: sequence of e2b, l1, and l2 (18-51 map units). | the dna sequence of 9991 nt, corresponding to 18-51 map units of mouse adenovirus type 1 (mav-1), was determined, completing the sequence of the larsen strain of mav-1. the length of the complete mav-1 genome is 30,946 nucleotides, consistent with previous experimental estimates. the 18-51 map unit region encodes early region 2b proteins necessary for adenoviral replication as well as late region l1 and l2 structural and packaging proteins. sequence comparison in this region with human adenoviru ... | 1997 | 9381795 |
| influence of bursectomy on bone growth and anemia induced by avian osteopetrosis viruses. | this study examines the contribution of the bursa of fabricius to the pathogenic manifestations of two myeloblastosis-associated viruses which primarily cause osteopetrosis [mav-1(o) and mav-2(o)]. mav-2(o) infection of surgically bursectomized 1-month-old chicks resulted in a rapidly fatal anemia whereas infection of untreated chicks of the same age resulted in a transient drop in hematocrit. surgical bursectomy of embryos before or after embryonal infection with mav-2(o) did not alter the cour ... | 1981 | 6257382 |
| transplacental infection with adeno-associated virus type 1 in mice. | adeno-associated type 1 parvovirus (aav) was detected in the kidneys and lungs of fetuses and newborns, when pregnant mice were injected subcutaneously with aav type 1 and murine adenovirus as a helper virus. these findings clearly indicate that transplacental infection with aav in rodents has been achieved. | 1980 | 6259087 |
| interstitial pneumonia induced by a plaque-type variant of mouse adenovirus. | | 1981 | 6265944 |
| a naturally occurring intestinal mouse adenovirus infection associated with negative serologic findings. | large basophilic intranuclear inclusions were observed in the intestinal epithelium of clinically normal mice. electron micrographs of the inclusions showed them to be caused by an adenovirus, even though serological testing for mouse adenoviruses in a complement fixation test using the fl strain of mouse adenovirus yielded no titers. a diagnosis of an adenovirus infection resembling that caused by the k87 strain was made. | 1983 | 6308344 |
| defective expression of mouse adenovirus fl in human cells. | hela cells infected with mouse adenovirus strain fl ( adfl ) produce at least 2000 times less virus than permissive mouse 3t3 cells. viral dna synthesis, however, proceeds unimpaired. the defect in virion production was linked to a dramatic reduction in the synthesis of adfl structural proteins, in particular the hexon. the identity of the adfl hexon gene product was recognized through its immunogenic reactivity towards an antiserum raised against the human adenovirus type 2 (ad2) hexon gene pro ... | 1982 | 6329682 |
| replication of mouse adenovirus strain fl dna. | | 1981 | 6927844 |
| murine viruses in an island population of introduced house mice and endemic short-tailed mice in western australia. | house mice (mus domesticus) were recently introduced to thevenard island, off the northwest coast of western australia. this island is also habitat for an endangered native rodent, the short-tailed mouse (leggadina lakedownensis). concerns have been raised that house mice may pose a threat to l. lakedownensis both through competition and as a source of infection. to assess the threat to l. lakedownensis posed by viral pathogens from m. domesticus, a serological survey was conducted from 1994 to ... | 1999 | 10231757 |
| novel expression of mouse adenovirus type 1 early region 3 gp11k at late times after infection. | mutations were introduced into mouse adenovirus type 1 (mav-1) early region 3 (e3) initiator codons by homologous recombination between viral dna and a plasmid containing a mutagenized e3 region. the resulting mutant virus, pme312, contained atg --> tta mutations at codon positions 1 and 4 and was expected to be null for the expression of the e3 proteins. however, gp11k, an mav-1 e3 glycoprotein of 14k molecular weight, was detected in mutant-infected cell lysates at levels about 10-12% of that ... | 1999 | 10364495 |
| cell-mediated immunity to mouse adenovirus infection. blocking of macrophage migration inhibition and t cell-mediated cytolysis of infected cells by anti-s antigen or anti-alloantigen serum. | migration of peritoneal exudate cells (pec), which were prepared from mice immunized against mouse adenovirus (m-ad), was inhibited upon exposure to the antigenic extract of m-ad-infected cells. this inhibition was shown to be blocked when infected cells or their extracts were pretreated with antiserum against m-ad-induced cell surface (s) antigen(s) or with antisera against alloantigens of infected cells. immune spleen cell-mediated cytolysis of m-ad-infected cells was also blocked in the prese ... | 1980 | 6968021 |
| restricted replication of mouse adenovirus strain fl in mouse balb/c cells transformed by simian adenovirus 7. | | 1982 | 7064348 |
| mouse adenovirus type 1 causes a fatal hemorrhagic encephalomyelitis in adult c57bl/6 but not balb/c mice. | mouse adenovirus type 1 (mav-1) produces a lethal disease in newborn or suckling mice characterized by infectious virus and viral lesions in multiple organs. previous reports of mav-1 infection of adult mice generally described serologic evidence of infection without morbidity or mortality. however, our current results demonstrate that mav-1 causes a fatal illness in adult c57bl/6(b6) mice (50% lethal dose, [ld50], 10(3.0) pfu) but not in adult balb/c mice at all of the doses tested (ld50, > or ... | 1995 | 7494276 |
| the distribution and kinetics of polyomavirus in lungs of intranasally infected newborn mice. | the primary cell types that sustain polyomavirus (py) replication following intranasal infection as well as the nature of the host cellular response to py were unknown. as this is an essential and specific site for virus entry, it seems likely that viral gene function must be adapted to these mucosal tissues. using immunohistochemistry and in situ hybridization, we determined the cell types in the lung that support py gene expression and replication following intranasal inoculation of newborn mi ... | 2000 | 10612660 |
| susceptibility and signs associated with mouse adenovirus type 1 infection of adult outbred swiss mice. | adult swiss outbred mice from two sources had a nearly 6,000-fold difference in susceptibility to mouse adenovirus type 1-induced disease. this difference was not attributable to differential organ tropism. signs associated with mouse adenovirus type 1 infection that have not been previously reported are described at the clinical, gross pathological, and histological levels. | 1995 | 7494327 |
| sequence and structural analysis of murine adenovirus type 1 hexon. | the genomic region encoding the major capsid protein (hexon) of murine adenovirus type 1 (mav-1) has been isolated and sequenced. the sequence predicts a 908 residue mav-1 hexon protein and is flanked by a portion of the upstream pvi gene and the downstream endoproteinase gene. the order of these genes and their location in the middle of the genome are the same as those found in other adenoviruses sequenced to date. multiple sequence alignment with the other five known hexon protein sequences re ... | 1994 | 7509368 |
| sequence of the mouse adenovirus serotype-1 dna encoding the precursor to capsid protein vi. | the nucleotide sequence predicted to encode the precursor to virion structural protein vi (previ) of mouse adenovirus (ad) serotype-1 (mav-1) was determined. the 237-amino-acid sequence has 45% identity and 66% similarity to the human ad serotype-2 previ sequence. there is a marked conservation at the c terminus, the last eleven residues of which may be necessary for activating the ad endoproteinase, and at the n terminus, including the consensus endoproteinase cleavage site. | 1995 | 7835716 |
| evidence for mimicry by viral antigens in animal models of autoimmune disease including myocarditis. | molecular mimicry of viral antigens with self determinants has been proposed as one of the pathogenic mechanisms in autoimmune disease. evidence of viral mimicry in animal models of autoimmunity is accumulating. murine adenovirus, semliki forest virus, lactate dehydrogenase-elevating virus, herpes simplex virus type-1, hepatitis b virus, encephalomyocarditis virus, theiler's murine encephalomyelitis virus, coxsackievirus and cytomegalovirus have been found to mimic physiologically important host ... | 2000 | 11130455 |
| complete nucleotide sequence of the mycoplasma virus p1 genome. | mycoplasma virus p1 is one of only four viruses isolated from the genus mycoplasma. the host for p1, mycoplasma pulmonis, possesses complex, phase-variable restriction and modification enzymes and the vsa family of phase-variable surface proteins. the ability of p1 virus to infect host cells is influenced by these phase-variable systems, rendering p1 a valuable tool for assessing host properties. the double-stranded p1 dna genome was sequenced (11,660 bp) and 11 orfs were identified. the predict ... | 2001 | 11322826 |
| interleukin-12 gene expression after viral infection in the mouse. | interleukin-12 is a lymphokine that triggers gamma interferon secretion by various cells and differentiation of t-helper lymphocytes towards the th1 subtype. since viruses are potent inducers of gamma interferon production and elicit immune responses most probably mediated by th1 cells, like b-cell immunoglobulin g2a secretion, we analyzed interleukin-12 message expression after infection of mice with lactate dehydrogenase-elevating virus, mouse hepatitis virus, and mouse adenovirus. our results ... | 1995 | 7853541 |
| sjl/j mice are highly susceptible to infection by mouse adenovirus type 1. | mouse adenovirus type 1 (mav-1) targets endothelial and monocyte/macrophage cells throughout the mouse. depending on the strain of mouse and dose or strain of virus, infected mice may survive, become persistently infected, or die. we surveyed inbred mouse strains and found that for the majority tested the 50% lethal doses (ld(50)s) were >10(4.4) pfu. however, sjl/j mice were highly susceptible to mav-1, with a mean ld(50) of 10(-0.32) pfu. infected c3h/hej (resistant) and sjl/j (susceptible) mic ... | 2001 | 11711594 |
| serological evidence of murine pathogens in wild grey squirrels (sciurus carolinensis) in north wales. | wild grey squirrels in north wales were examined for their serological response to a range of laboratory mouse pathogens. nineteen squirrels were tested against 14 organisms and a high seroprevalence was found to several, including murine cytomegalovirus, mouse adenovirus, reovirus 3, rotavirus and sendai virus. four of the squirrels were seropositive for lymphocytic choriomeningitis virus, a zoonotic pathogen. none of the infections has previously been reported in squirrels. | 2002 | 12019534 |
| genetic relationship between mouse adenovirus-2 (strain k87) and human adenovirus-2. | the dna of mouse adenovirus strain k87 (mad-2) was cloned and mapped with restriction endonucleases bglii, clai, ecori, hindiii and sphi. large differences were found between the mad-2 and mad-1 (strain fl) dna molecules in terms of number and location of restriction sites. the mad-2 genome also appeared as larger in size than the mad-1 genome (34.72 kb vs. 30.14 kb). our results confirm the existence of two distinct adenovirus species in the mouse. hybridization experiments, on the other hand, ... | 1994 | 8125249 |
| propagation of mouse adenovirus on cell lines of human origin. | | 1964 | 14207231 |
| increased susceptibility of mice infected with mouse adenovirus to escherichia coli-induced pyelonephritis. | mouse adenovirus causes a persistent infection in the mouse kidney that produces extensive mononuclear cell infiltrates in cortex and medulla. tubular necrosis, dilatation, and occasional collapse occur but no glomerular changes or periglomerular fibrosis have been observed. acute and chronic adenovirus infection of the kidney predispose the kidney to develop acute pyelonephritis when the mouse is challenged by the intravenous or retrograde route with escherichia coli. | 1964 | 14238929 |
| molecular cloning, physical mapping and cross-hybridization of the murine adenovirus type 1 and type 2 genomes. | murine adenovirus (mad) type 1 strain fl and type 2 strain k87 genomes were cloned into plasmid pat153 as hindiii restriction fragments. the mad-1 and mad-2 dna genomes, 30.10 kb and 34.71 kb in length respectively, were mapped using bglii, clai, ecori, hindiii and sphi restriction endonuclease cleavage sites. in view of the large differences found between the mad-1 and mad-2 genomes in terms of the number and location of restriction sites, cross-hybridization experiments were performed. homolog ... | 1994 | 8207397 |
| prevalence of viral antibodies and helminths in field populations of house mice (mus domesticus) in southeastern australia. | a 13-month study of wild mice (mus domesticus) in wheatlands in southeastern australia contrasted changes in the seroprevalence of antibody to 13 viruses and the occurrence of helminths with changes in their population dynamics. mice were seropositive for mouse hepatitis virus (mhv), rotavirus, minute virus of mice (mvm), mouse adenovirus (madv), reovirus (reo 3), and murine cytomegalovirus (mcmv). the seroprevalences of all but rotavirus varied significantly with time and increased with host de ... | 1993 | 8472782 |
| rederivation of transgenic and gene-targeted mice by embryo transfer. | research on genetically engineered mice provides insights into the etiology, therapy, and genetic basis of human diseases. an important variable that affects the results of mouse studies is the health status of the animals. pathogen burdens may confound observations and obscure underlying mechanisms. mouse resource centers frequently rederive infected mouse strains. we review our experience on the use of a well-established technique, embryo transfer to rederive infected mouse strains. the follow ... | 2004 | 15517995 |
| a serologic survey for viruses and mycoplasma pulmonis among wild house mice (mus domesticus) in southeastern australia. | plasma samples from 267 wild house mice (mus domesticus) trapped at 14 sites in southeastern australia were screened for antibody to 14 viruses normally associated with laboratory-reared rodents and to mycoplasma pulmonis. serologic prevalence was high for murine cytomegalovirus (99%, n = 94), murine coronavirus (95%), and murine rotavirus (74%). samples from mice collected at all sites contained antibody to these viruses. the serologic prevalence was lower for mouse adenovirus, strain k87 (37%) ... | 1993 | 8487371 |
| contribution of mav-1-induced nephroblastoma to the study of genes involved in human wilms' tumor development. | the avian nephroblastoma induced by myeloblastosis-associated virus constitutes a unique animal model in which to study genes involved in the initiation and progression of the human wilms' tumor. along this line, we have identified a new cellular gene (nov, for nephroblastoma overexpressed) whose expression is regulated in vitro by the wt1 proteins and is stimulated in all avian nephroblastomas. the nov gene is also conserved in human and its expression is altered in wilms' tumors. in both speci ... | 1994 | 8519812 |
| conservation of dna sequence in the predicted major late promoter regions of selected mastadenoviruses. | the major late promoter (mlp) of the subgroup c human adenoviruses is a preeminent model for the study of the mechanisms of basal and activated transcription, both in vivo and in vitro. however, while the structure and function of the human virus mlp has been the subject of extensive investigation, the conservation of the various promoter elements among the adenoviruses from different species has not been examined. conservation of specific elements would strongly suggest the importance and unive ... | 1996 | 8661390 |
| analysis of early region 3 mutants of mouse adenovirus type 1. | early region 3 (e3) of mouse adenovirus type 1 has the potential to produce three proteins which have identical amino termini but unique carboxy-terminal sequences. three recombinant deletion viruses were constructed so that each could produce only one of the three e3 proteins. a fourth mutant that should produce no e3 proteins was also constructed. these recombinants were able to grow in mouse 3t6 cells and produced wild-type levels of viral mrnas and proteins except for those specifically dele ... | 1996 | 8709206 |
| identification of quantitative trait loci for susceptibility to mouse adenovirus type 1. | adult sjl/j mice are highly susceptible to mouse adenovirus type 1 (mav-1) infections, whereas other inbred strains, including balb/cj, are resistant (k. r. spindler, l. fang, m. l. moore, c. c. brown, g. n. hirsch, and a. k. kajon, j. virol. 75:12039-12046, 2001). using congenic mouse strains, we showed that the h-2(s) haplotype of sjl/j mice is not associated with susceptibility to mav-1. susceptibility of mav-1-infected (balb/cj x sjl/j)f(1) mice was intermediate between that of sjl/j mice an ... | 2005 | 16103204 |
| interaction of mouse adenovirus type 1 early region 1a protein with cellular proteins prb and p107. | we demonstrated functional associations between mouse adenovirus type 1 (mav-1) early region 1a (e1a) protein and both the mouse retinoblastoma protein (prb) and the mouse prb-related protein, p107. interactions between mav-1 e1a and mouse prb or mouse p107 proteins were examined in infected cell lysates using a mouse embryonic fibroblast cell line infected with wild-type and mutant mav-1 viruses. using a polyclonal antibody to mav-1 e1a, exogenously added mouse prb or mouse p107 was coimmunopre ... | 1996 | 8862413 |