| ultrastructural studies on the replication of herpes virus ateles-73 in owl monkey kidney cells. | the replicative cycle of herpesvirus ateles, strain 73 (hva-73), was examined in the electron microscope and compared to that of other herpesviruses known to be oncogenic. a relatively slow replicative cycle of hva-73 in owl monkey kidney (omk) cells allowed us to distinguish cytoplasmic and nuclear stages of replication, comprising virus uptake, transport, maturation, and extrusion. virus uptake was observed within 10 hours of infection and occurred both as a result of fusion between virus and ... | 1979 | 114147 |
| a killed vaccine derived from the oncogenic herpesvirus ateles. | a killed herpesvirus vaccine was prepared by inactivation of the oncogenic herpesvirus ateles (hva) with heat and formaldehyde. the vaccine proved safe in 9 marmosets (saguinus oedipus) during a period of 461 days. the vaccinated marmosets developed high titers of serum antibodies against hva and were resistant to 316 lethal dose 50 (ld50) cell-free hva; the nonvaccinated control monkeys died of malignant lymphoma. the 5 challenged monkeys are clinically well and have now been under observation ... | 1975 | 808642 |
| trans activation of the thymidylate synthase promoter of herpesvirus saimiri. | herpesvirus saimiri has been shown to possess a thymidylate synthase (ts) gene that is unusual in its transcriptional regulation. although ts is believed to be required for viral dna synthesis, the ts-specific 2.5-kb mrna was found most abundantly during the late phases of asynchronous virus replication in permissive cultures. to study the kinetics of gene activation, the ts promoter and regulatory sequences were cloned upstream of the chloramphenicol acetyltransferase (cat) gene. no cat express ... | 1990 | 2170674 |
| genome organization of herpesvirus aotus type 2. | herpesvirus aotus type 2, a virus commonly found in owl monkeys without overt disease, has a similar genome structure to the oncogenic herpesviruses of nonhuman primates (herpesvirus saimiri, herpesvirus ateles). virion dna of herpesvirus aotus type 2 (m-dna) has an unique 110-kilobase-pair region of low g + c content (40.2%, l-dna), inserted between stretches of repetitive h-dna (68.7% g + c, about 41 kilobase pairs per molecule) that are variable in length. a minority of virions contain defect ... | 1985 | 2981331 |
| pathologic features of herpesvirus ateles lymphoma in cotton-topped marmosets (saguinus oedipus). | | 1972 | 4630607 |
| two distinct gamma-2 herpesviruses in african green monkeys: a second gamma-2 herpesvirus lineage among old world primates? | primate gamma-2 herpesviruses (rhadinoviruses) have so far been found in humans (kaposi's sarcoma-associated herpesvirus [kshv], also called human herpesvirus 8), macaques (macaca spp.) (rhesus rhadinovirus [rrv] and retroperitoneal fibromatosis herpesvirus [rfhv]), squirrel monkeys (saimiri sciureus) (herpesvirus saimiri), and spider monkeys (ateles spp.) (herpesvirus ateles). using serological screening and degenerate consensus primer pcr for the viral dna polymerase gene, we have detected seq ... | 2000 | 10627572 |
| herpesvirus saimiri. | herpesvirus saimiri (saimiriine herpesvirus 2) is the classical prototype of the gamma(2)-herpesviruses or rhadinoviruses, which also contains a human member, the kaposi's sarcoma-associated herpesvirus. the t-lymphotropic herpesvirus saimiri establishes specific replicative and persistent conditions in different primate host species. virtually all squirrel monkeys (saimiri sciureus) are persistently infected with this virus. in its natural host, the virus does not cause disease, whereas it indu ... | 2001 | 11313011 |
| t-cell transformation and oncogenesis by gamma2-herpesviruses. | gamma2-herpesviruses, also termed rhadinoviruses, have long been known as animal pathogens causing lymphoproliferative diseases such as malignant catarrhal fever in cattle or t-cell lymphoma in certain neotropical primates. the rhadinovirus prototype is herpesvirus saimiri (hvs), a t-lymphotropic agent of squirrel monkeys (saimiri sciureus); herpesvirus ateles (hva) is closely related to hvs. the first human rhadinovirus, human herpesvirus type 8 (hhv-8), was discovered a decade ago in kaposi's ... | 2005 | 15797445 |
| simian homologues of human herpesvirus 8. | gamma-herpesviruses can be found in most primates including old world an new world monkeys. the gamma-herpesvirinae are grouped into two classes: lymphocryptoviruses (gamma1) and rhadinoviruses (gamma2). the lymphocryptoviruses include epstein-barr virus, lymphocryptovirus of rhesus monkeys, and herpesvirus papio of baboons. rhadinoviruses that infect new world monkeys include herpesvirus saimiri, whose natural host is the squirrel monkey, and herpesvirus ateles, which infects spider monkeys. rh ... | 2001 | 11313010 |
| herpesvirus ateles gene product tio interacts with nonreceptor protein tyrosine kinases. | herpesvirus ateles is a gamma-2-herpesvirus which naturally infects spider monkeys (ateles spp.) and causes malignant lymphoproliferative disorders in various other new world primates. the genomic sequence of herpesvirus ateles strain 73 revealed a close relationship to herpesvirus saimiri, with a high degree of variability within the left terminus of the coding region. a spliced mrna transcribed from this region was detected in new world monkey t-cell lines transformed by herpesvirus ateles in ... | 1999 | 10233922 |
| identification of a thymidylate synthase gene within the genome of chilo iridescent virus. | the thymidylate synthase (ts, ec 2.1.1.45) is essential for the de novo synthesis of dtmp in pro- and eucaryotic organisms. consequently it plays a major role in the replication of the dna genome of a cell or a dna virus. the gene encoding the ts of chilo iridescent virus (civ) was identified by nucleotide sequence analysis of the viral genome and was mapped within the ecori civ dna fragments g and r. computer assisted analysis of the dna nucleotide sequence between the genome coordinates 0.482 ... | 1998 | 9926400 |
| htlv-ii non-integrated malignant lymphoma induction in japanese white rabbits following intravenous inoculation of htlv-ii-infected simian leukocyte cell line (si-iia). | lymphoma induction in rabbits by an unknown factor derived from an htlv-ii-producing simian (cynomolgus) leukocyte cell line (si-iia) is reported. thirteen of 17 male japanese white rabbits (76%) inoculated intravenously with si-iia cells developed malignant lymphoma including hodgkin-like lymphoma between 62 and 167 days after inoculation. histologically, there was extensive diffuse or nodular infiltration of either large cell type or mixed type lymphoma cells in many organs, frequently involvi ... | 1994 | 7928626 |
| a single major immediate-early virus gene product is synthesized in cells productively infected with herpesvirus saimiri. | a major virus-specific immediate-early (ie) polypeptide with an apparent mol. wt. of 52 000 (52k) was synthesized immediately after the removal of a cycloheximide block applied to owl monkey kidney cell cultures at the time of infection with high multiplicities of herpesvirus saimiri (hvs). the ie 52k polypeptide was phosphorylated and accumulated rapidly and efficiently in the nucleus of infected cells. monoclonal antibodies to ie 52k and to a major non-structural delayed-early (de) dna-binding ... | 1984 | 6086813 |
| arrangement of repetitive sequences in the genome of herpesvirus sylvilagus. | herpesvirus sylvilagus is a lymphotropic (type gamma) herpesvirus of cottontail rabbits (sylvilagus floridanus). analysis of virion dna of herpesvirus sylvilagus has revealed that the genome consists of one stretch of about 120 kilobase pairs of internal, unique dna flanked by a variable number of 553-base-pair tandem repeats. the g + c content of the repetitive dna is extremely high (83%), as determined by sequencing. the organization of the herpesvirus sylvilagus genome is, therefore, similar ... | 1989 | 2911114 |
| herpesvirus ateles immortalizes in vitro a cd3+cd4+cd8+ marmoset lymphocyte with nk function. | herpesvirus ateles, nonpathogenic in its natural host, the spider monkey, induces a fatal lymphoproliferative syndrome in a variety of new world primate species. whereas the closely related new world primate virus herpesvirus saimiri immortalizes in vitro common marmoset lymphocytes that express a tcr and phenotypically are cd4-cd8+nkh1+, we now show that h. ateles-immortalized marmoset lymphocytes are cd3+ and cd4+. furthermore, these cd4+ lymphocytes coexpress cd8 and nkh1. the nk function of ... | 1988 | 2828471 |
| experimental infection of callithrix jacchus marmosets with herpesvirus ateles, herpesvirus saimiri, and epstein barr virus. | we inoculated common marmosets (callithrix jacchus) with herpesvirus ateles (hva), herpesvirus saimiri (hvs), and epstein-barr virus (ebv). hva-induced tumors contained several cell types, including giant cells reminiscent of the sternberg-reed cells observed in human hodgkin's disease. hvs and ebv did not induce tumors, although hvs was present in lymphocytes and elicited a strong antibody response. ebv elicited only a variable antibody response. we feel that more common marmosets should be use ... | 1978 | 208678 |