| old and new dangers of blood transfusion (author's transl). | the predominant danger of blood transfusion, even after the discovery of the abo and rh systems, is the immunological risk. this led in 1940 to a regulation of blood transfusion in germany by official guidelines which were constantly adjusted in the light of new research results. the dangers due to deterioration on storage still receive too little attention although these may be of greater danger to the patient than immunisation risk. also the assessment of other medical problems of transfusion ... | 1976 | 5668 |
| effects of exogenous interferon in cytomegalovirus infections complicating bone marrow transplantation. | | 1976 | 7372 |
| bone marrow transplantation in acute leukemia using intensive chemoradiotherapy (scari--ucla). | | 1976 | 11592 |
| activation of latent viruses following bone marrow transplantation. | | 1976 | 11595 |
| bone marrow transplantation with intensive combination chemotherapy/radiation therapy (scari) in acute leukemia. | fifteen patients with acute leukemia resistant to standard chemotherapy were treated by bone marrow transplantation from hla-matched siblings after conditioning with a new combination chemotherapy/radiation therapy regimen--scari. scari consists of 5 days of high-dose cytosine arabinoside and 6-thioguanine followed by 3 days of daunorubicin. after a rest period, cyclophosphamide and total-body irradiation are given sequentially. this regimen had acceptable morbidity. median survival was 169 days ... | 1977 | 13696 |
| thymidine-kinase in cytomegalovirus infected cells. | in human diploid fibroblast lep cells infected with ad169 strain of human cytomegalovirus (cmv) a sharp increase of cytosol thymidine kinase activity was observed. the properties of the cytosol enzymes from infected and non-infected cells were compared. no significant differences between the enzymes from infected and control cells were observed in substrate specificity, ph dependence, thermostability and relative electrophoretic mobility. human sera containing high titres of cmv complement-fixin ... | 1976 | 13768 |
| one hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation. | one hundred patients, 54 with acute myelogenous leukemia (aml) and 46 with acute lymphoblastic leukemia (all), considered to be in the end stages of their disease, after combination chemotherapy were treated by marrow transplantation. all patients were given a marrow graft from an hla-identical sibling after receiving 1000-rad total body irradiation (tbi). one group of 43 patients was given cyclophosphamide (cy), 60 mg/kg on each of 2 days, 5 and 4 days before tbi. in a second group of 31 patien ... | 1977 | 14751 |
| late persistence of serum gamma-glutamyl transpeptidase activity after mononucleosis. report of 3 cases. | gamma-glutamyl transpeptidase (ggtp) is a sensitive but nonspecific index hepatobiliary disease. in infectious mononucleosis (im) or the mononucleosis-like disease attributable to cytomegalovirus (cytomegalovirus-induced im), ggtp reverted to normal later than aspartate aminotransferase and alkaline phosphatase. in three cases elevated serum ggtp activity persisted for up to 24 months -- raising the question of persistent 'post-im' hepatitis. such prolonged ggtp activity was unusual in other lat ... | 1977 | 15921 |
| human cytomegalovirus. a review of developments between 1970 and 1976. i. clinical developments. | cytomegalovirus (cmv), like other members of the herpesviruses, is widely distributed in human populations where the frequency of seropositive individuals is influenced by such factors as age, sex and socio-economic conditions. while this virus causes such diseases as mononucleosis, it is also implicated in autoimmune phenomena and plays an adverse role renal and bone marrow transplantation. perhaps the most menacing aspect of cmv is the role which it play in congenital malformations resulting f ... | 1977 | 16671 |
| enhancement of murine cytomegalovirus infection during graft-vs.-host reaction. | a mouse model was used for elucidation of the role of a graft-vs-host reaction in promoting cytomegalovirus infection. f1 (dba/2 x c3h/he) hybrid mice were infected with murine cytomegalovirus. five weeks later, a graft-vs.-host reaction was produced in the chronically infected animals by the administration of multiple doses of dba/2 parental splenocytes. cytomegalovirus was recovered more often from the organs of mice undergoing graft-vs.-host reaction than from those of control animals (p less ... | 1977 | 16972 |
| effect of murine cytomegalovirus on cell-mediated immunity. | | 1977 | 17196 |
| immunological activation of endogenous oncogenic viruses. | | 1976 | 17342 |
| stimulation of cellular thymidine kinases by human cytomegalovirus. | thymidine kinase (tk) activity in wi-38 and mrc-5 human fibroblasts was analyzed by discontinuous polyacrylamide gel electrophoresis (disc-page) and discontinuous glycerol gradient electrophoresis (disc-gep) after subculture or human cytomegalovirus (hcmv) infection. two peaks of tk activity with different relative fraction-of-migration (r(f)) values were resolved by disc-page or disc-gep in extracts from log-phase and infected cells. growing wi-38 cells expressed a slowly migrating (r(f) = 0.14 ... | 1977 | 20515 |
| a prospective analysis interstitial pneumonia and opportunistic viral infection among recipients of allogeneic bone marrow grafts. | a prospective study of 80 bone marrow transplant recipients with acute leukemia and aplastic anemia employed serial viral cultures, determination of complement-fixing antibody to cytomegalovirus (cmv), and study of material obtained from open lung biopsy and autopsy. there were 43 episodes of interstitial pneumonia, 28 of which were fatal. about 40% of the cases were idiopathic. cmv was the most common candidate pathogen, present in 47% of affected lungs. by a median of 53 days following transpl ... | 1977 | 21931 |
| electron microscopic studies of the replication of mouse cytomegalovirus in mouse embryo cells. | during the replication a pathogenic and a non-pathogenic strain of mouse cytomegalovirus in mouse embryo cells, three types of progeny virus particles were observed in both cases; the virus yields of the two strains differed considerably. | 1977 | 23668 |
| use of gel precipitin test in the diagnosis of cytomegalovirus infections. | cytomegalovirus (cmv) antibody was detected in human sera by the gel precipitin test. the results were closely related to those obtained by complement fixation. the simplicity of the test makes it useful for the routine serological diagnosis of cmv infection. | 1978 | 25010 |
| effect of 6-mercaptopurine on cytomegalovirus replication and complement-fixing antigen formation. | | 1978 | 26205 |
| cytomegalovirus infections in the human population. | diagnostic and clinical experience gained in the period from 1966--1977 is summarized. cytomegalovirus was isolated from 35 sucklings and 5 infants aged more than 1 year as well as from necropsy materials from 10 sucklings. the most frequently involved were the respiratory tract (77.8%), liver (53.5%) and haematopoetic apparatus (42.2%). congenital defects were found in 22.2%. the incidence in the population varied from 20% in sucklings to 50--60% in persons aged over 40 years. the incidence of ... | 1978 | 29471 |
| marrow transplantation for treatment of aplastic anaemia. | | 1978 | 31255 |
| bone marrow transplantation for acute leukemia using a histocompatible paternal donor. | a bone marrow transplantation from an hla-identical, mlc nonreactive paternal donor has been performed in a patient with acute lymphoblastic leukemia resistant to drug treatment. prompt engraftment was documented; however, the patient died of interstitial pneumonitis due to cytomegalovirus 65 days after transplant. clinical manifestation of graft-versus-host reaction was mild. recurrence or persistence of leukemia was found at the time of death using cytogenetic markers and determination of the ... | 1979 | 33519 |
| effects of cytosine arabinoside on the incorporation of pyrimidine nucleosides into hamster cells transformed by herpes simplex type 1 and type 2 viruses and by human cytomegalovirus. | the incorporation of 3h-thymidine and 3h-deoxycytidine into acidoprecipitable fraction of hamster cells transformed by herpes simplex viruses type 1 and type 2 and of 3h-thymidine into hamster cells transformed by human cytomegalovirus was found to be resistant to the action of cytosine arabinoside. more 3h-thymidine was incorporated into these cells in the presence than in the absence of the drug. similar stimulaton of 3h-thymidine uptake could be achieved by using unlabelled deoxycytidine inst ... | 1979 | 40418 |
| comparison of different serological methods in diagnosing primary and recurrent cytomegalovirus infections in pregnancy. | | 1979 | 40424 |
| congenital cytomegalovirus infection after maternal renal transplantation. | congenital cytomegalovirus infection was found in an infant whose mother had a successful renal transplant and was treated with immunosuppressant therapy before and during pregnancy. although so far not experiencing any untoward infections, the child had impaired t-lymphocyte function and subnormal serum-iga. | 1975 | 48947 |
| the epstein-barr virus and malignancy: molecular evidence. | | 1975 | 50897 |
| treatment of severe combined immunodeficiency with bone-marrow from an unrelated, mixed-leucocyte-culture-non-reactive donor. | a 7-month-old boy with severe combined immunodeficiency had no relative who was a suitable bone-marrow donor as determined by mixed-leucocyte-culture (m.l.c.) testing. in the general population an m.l.c.-nonreactive, unrelated donor was found among individuals who were identical with our patient at the four locus. following a bone-marrow transplant this child showed signs of rapid immunological reconstitution and only a mild graft-versus-host reaction. unfortunately, the child died 31 days post- ... | 1975 | 51239 |
| the fractionation of cerebrospinal fluid proteins by cellulose acetate electrophoresis in children with infectious diseases of the central nervous system (author's transl)]. | the increased permeability of the blood-brain barrier during acute inflammation of the central nervous system leads to changes of the cerebrospinal fluid (c.s.f.) protein pattern. initially, in the cases of bacterial meningitis, cellulos acetate electrophoresis revealed decreased prealbumin, albumin and tau-globulin fraktion whereas alpha- and gamma-globulin fractions were found increased. in later stages of purulent inflammation a hydrocephalus occurred in five children, associated with an incr ... | 1975 | 52834 |
| clinical and serological analysis of transfusion-associated hepatitis. | of 108 prospectively followed, multiply transfused, open-heart-surgery patients, 12 (11%) developed hepatitis. patients received only volunteer donor blood tested for hepatitis-b surface antigen (hbsag) prior to transfusion by counterelectrophoresis (c.e.p.). 4 of the 12 patients developed hepatitis-b-virus infection. subsequent testing of donor serums by solid-phase radioimmunoassay (r.i.a.) revealed that an r.i.a.-positive, c.e.p.-negative blood unit was transfused to 3 of the 4 type-b hepatit ... | 1975 | 53329 |
| efficacy of prophylactic gamma-globulin in preventing non-a, non-b post-transfusion hepatitis. | of 279 cardiac-surgery patients receiving a mean of twelve transfusions, 47 had significantly increased transaminase concentrations 14 to 180 days postoperatively and 10 were icteric. preoperatively, each patient randomly received high-titre hbsab gamma-globulin, normal gamma-globulin, or placebo and was followed at intervals for 9 months. only 3 patients had serological evidence of hepatitis-b infection. 3 additional patients had serological evidence of cytomegalovirus infection, while none had ... | 1976 | 55838 |
| [vaccination against viral diseases]. | | 1976 | 56296 |
| letter: infantile spasms and cytomegalovirus infection. | | 1976 | 60616 |
| protein patterns of the cerebrospinal fluid in children with cerebral palsy. | cerebrospinal fluid in 69 children with cerebral palsy (cp) of different etiology was examined by an improved method of agarose-gel electrophoresis. the protein pattern was normal in 12 cases only. in children with cp caused by congenital and postnatal infections raised psi-globulin fractions and the appearance of oligoclonal phi-globulin bands were the most obvious finding. in patients with cp due to malformations or perinatal brain damage and in children with cp of unknown etiology decreased p ... | 1976 | 60728 |
| cytomegalovirus specific igm and igg response in humans studied by radioimmunoassay. | an indirect solid phase micro-radioimmunoassay (ria) was adapted for the measurement of anti-cytomegalovirus class-specific immunoglobulin m (igm) and immunoglobulin g (igg). cytomegalovirus (cmv) antigen (ag) was added to the wells of microtiter plates and desiccated onto the bottom surface of the wells. serial dilution of human cmv antisera were added and allowed to react with the ag. the amount of viral antibody (ab) was determined by measuring the specific binding of 125i-labeled goat anti-h ... | 1976 | 62802 |
| detection of early antigens in nuclei of cells infected with cytomegalovirus or herpes simplex virus type 1 and 2 by anti-complement immunofluorescence, and use of a blocking assay to demonstrate their specificity. | skin fibroblasts exposed to cytosine arabinoside (ara c) were infected with either cytomegalovirus (cmv) or herpes simplex virus (hsv) type 1 and 2. herpesvirus-determined early antigens (hv-ea), detected by anti-complement immunofluorescence (acif), occurred primarily in the nucleic, and the specificity of these results was established by an acif blocking reaction using f(ab')2 fragments of human and hyperimmune reference sera. direct tests with selected sera and cross-blocking experiments betw ... | 1977 | 64461 |
| cytomegalovirus infection in severely burned patients. | | 1976 | 65087 |
| [problems of the prenatal prophylaxis of the viral infections (author's transl)]. | the present review will supply an simple notice over the characters of every one viral infection interesting the materne-faetal conditions, and also propose the most convenient intervention for each observed type. a not small lot of these problems are not resolved in the field of the antiviral immunity regarding the mother and newborn. | 1976 | 65942 |
| rapid detection of antibodies to cytomegalovirus by counterimmunoelectrophoresis. | a new method for the detection of precipitating antibody to cytomegalovirus by counterimmunoelectrophoresis (ciep) is described. fourteen of 15 adult sera (95%) with igm-specific antibodies (as detected by immunofluorescence) and complement-fixing antibodies to cytomegalovirus in high titers gave positive reactions by this method. control sera from 156 patients and 40 normal subjects were negative by ciep. one of 32 individuals acutely infected with other members of the herpesvirus group gave a ... | 1977 | 66299 |
| aplastic anaemia, bone-marrow transplantation, and polyoma and other virus infections. | | 1977 | 66488 |
| specific cell-mediated immune defect in congenital cytomegalovirus infection. | | 1977 | 66616 |
| an immunofluorescence technique with counterstain on fixed cells for the detection of antibodies to human herpesviruses; antibody patterns in patients with hodgkin's disease and nasopharyngeal carcinoma. | an indirect immunofluorescence (if) test on fixed cells with evans' blue counterstain is described for all four human herpesviruses, i.e., herpes simplex virus type 1 and type 2 (hsv-1 and hsv-2), varicella-zoster virus (vzv), cytomegalovirus (cmv) and epstein-barr virus (ebv). comparison with immunodiffusion (id) for hsv-2 and with id and complement fixation (cf) for vzv and cmv demonstrated the specificity and high sensitivity of the if test. also introduced is a modification of the anti-compl ... | 1976 | 67099 |
| aetiology of acute epididymitis. | 24 patients with acute epididymitis were examined and underwent urethral and urine cultures for neisseria gonorrhoeae, ureaplasma urealyticum, herpes-simplex virus, chlamydia trachomatis, cytomegalovirus, and gram-negative aerobic bacteria. the results suggest that in young men the sexually transmitted organisms which cause urethritis (n. gonorrhoeae, c. trachomatis, and possibly u. urealyticum) may also lead to acute epididymitis, whereas in older men coliforms and pseudomonas are the predomina ... | 1977 | 67333 |
| occurrence of genital herpes simplex and cytomegalovirus infections in pregnancy. | a total of 244 pregnant women, 172 in the first and 72 in the third trimester, were screened for genital herpes simplex (hsv) and cytomegalovirus (cmv) infections using virus isolation, cytological examination and serological studies. in addition, immuno-fluorescence staining of exfoliated cervical cells was used for the detection of hsv infections. herpes simplex virus (hsv) could not be isolated and no characteristic hsv altered cells were found in cytological (papa) smears. cytomegalovirus wa ... | 1977 | 67744 |
| cytomegalovirus and cancer of the prostate: in vitro transformation of human cells. | urogenital tissue specimens were maintained in culture for 2 years. epithelioid growth was enhanced with use of collagenase digestion rather than trypsinization. twenty of 34 prostate cancer cell cultures survived more than ten in vitro passages, during which time four of 20 demonstrated epithelioid morphology. one epithelioid line (t-157) survived 32 in vitro passages. the cells demonstrated lack of contact inhibition in culture, were slightly positive in acid phosphatase tests, and reacted pos ... | 1977 | 68820 |
| cytomegalovirus-directed lymphocyte reactivity in healthy adults tested by a cmv-induced lymphocyte transformation test. | a cytomegalovirus (cmv) induced lymphocyte tranformation test (ltt) performed as a microtechnique assay is described. investigations were done in a group of twenty-five healthy adults with normal lymphocyte reactivity to phytohaemagglutinin and previously encountered antigens. lymphocyte reactivity was established in cmv-seropositive persons using heat-inactivated cell-free cmv strain ad 169 in an optimal stimulating dose of 10(1-5) tcid 50. positive cmv-ltt results were shown to be induced by p ... | 1977 | 70294 |
| lymphocyte reactivity against virally transformed cells in patients with urologic cancer. | lymphocytes from patients with urologic cancer were tested in microcytotoxicity assays against human cells transformed by cytomegalovirus. human lymphocytes were significantly cytotoxic against the transformed cell line when compared to a normal human control cell line. patients with prostatic carcinoma demonstrated greater target cell reduction than those with benign prostatic hyperplasia. | 1977 | 72168 |
| specific cell-mediated immune defect in active cytomegalovirus infection of young children and their mothers. | 4 young children with active cytomegalovirus (c.m.v.) infection were found, by an in-vitro lymphocyte-proliferation assay, to have a c.m.v.-specific cell-mediated immune defect. these children had antibodies to c.m.v. and were actively shedding c.m.v. in the urine when studied. their general cellular immune responses were intact, with normal numbers of t lymphocytes and normal in-vitro responses to mitogens and at least one antigen. 3 of the 4 mothers studied shortly after delivery had decrease ... | 1977 | 72195 |
| transfer-factor treatment in congenital cytomegalovirus infection. | when two doses of transfer factor were given to three infants with congenital cytomegalovirus (c.m.v.) infection, urine cultures for c.m.v. became negative, briefly, after five of the six doses. | 1977 | 72959 |
| infantile spasms and cytomegalovirus infection. | | 1976 | 73776 |
| herpetic encephalitis with associated cytomegalovirus infection and myoclonus. | | 1977 | 73924 |
| cytomegalovirus vaccination and renal transplantation. | | 1978 | 74583 |
| immune responses in children with congenital cytomegalovirus and their mothers ]letter]. | | 1977 | 74761 |
| transmission of non-a, non-b hepatitis from man to chimpanzee. | non-a, non-b hepatitis was transmitted to four colony-born chimpanzees by intravenous inoculation of human sera. two chimpanzees were inoculated with serum from a patient with a clinical and serological diagnosis of chronic non-a, non-b hepatitis whose blood appeared to transmit this disease to a nurse following accidental needle-stick, and the other two chimpanzees were inoculated with serum from either of two former blood-donors whose hbsag-negative blood appeared to transmit clinically recogn ... | 1978 | 76018 |
| immune responses in cytomegalovirus infection. | | 1978 | 76790 |
| cytomegalovirus d.n.a. and adenocarcinoma of the colon: evidence for latent viral infection. | the cause of adenocarcinoma of the colon has not been proven and a viral association has not been reported with this disease. a sensitive biochemical technique for the detection of viral nucleic acid was used to determine whether one type of herpesvirus, namely a human strain of cytomegalovirus, was uniquely present in tumour tissue. 24 specimens of colon, obtained at surgery from 14 patients, were analysed by membrane cr.n.a.-d.n.a. hybridisation. 4 of 7 tumours of the colon were definitely pos ... | 1978 | 76890 |
| non-a, non-b hepatitis. | | 1978 | 77141 |
| immune competence in a patient with hodgkin's disease and relapsing toxoplasmosis. | a 40 year old woman with hodgkin's disease twice developed signs of encephalitis while being treated with prednisone and cyclophosphamide for 10 months. since on both occasions her toxoplasma dye test titer was 1 : 8000 or higher, she was treated on suspicion of toxoplasmosis with sulfadizine and pyrimethamine. her tumor therapy was changed to bleomycin with lower doses of prednisone for 12 months. after death from central pontine myelinolysis, toxoplasma and cytomegalovirus could be isolated, b ... | 1978 | 77257 |
| humoral and cellular immune response of prostatic cancer patients to cytomegalovirus-related antigens. | | 1978 | 77357 |
| [use of the immunofluorescence method for the diagnosis of cytomegalovirus infection]. | the method of immunofluorescence for diagnosis of cytomegalic infection vitally and in cases of fatal outcomes of the infection is proposed. recommendations for the preparation of anticytomegalovirus immune sera for an indirect modification of the method are presented alongside with the characteristics of procedure for the immunofluorescent analysis of cytomegalovirus. the clinico-laboratory diagnostic studies have demonstrated certain advantages of the proposed method over virus isolation from ... | 1978 | 78591 |
| strain-specific local and systemic cell-mediated immune responses to cytomegalovirus in humans. | employing the techniques of complement fixation, immunofluorescence, and in vitro lymphocyte transformation assay, the antibody and cell-mediated immunity to cytomegalovirus (cmv) were studied in the serum, peripheral blood lymphocytes, tonsillar lymphocytes, and cord blood lymphocytes. the study population consisted of 32 children undergoing tonsillectomy and adenoidectomy. in the lymphocyte transformation assay, three strains of cmv (ad-169, adh-1-41, and davis), herpes simplex type 1, and phy ... | 1978 | 78898 |
| specificity of the blastogenic response of human mononuclear cells to herpesvirus antigens. | peripheral blood mononuclear (pbm) cells from donors with a history of prior infection with herpes simplex virus, varicella-zoster virus, and/or cytomegalovirus were cultured for 2 to 8 days with glycine-extracted antigens prepared from these viruses and from infectious bovine rhinotracheitis virus. the proliferative response of pbm cells from all donors was specific during the first 6 days in culture. during this period the cellular immune responses of the seronegative donors were clearly diffe ... | 1978 | 78901 |
| increased serum alpha-fetoprotein levels in cytomegalovirus infections. | among 54 patients with a clinically and serologically verified cytomegalovirus infection, 8 (15%) had raised alpha-fetoprotein (afp) levels in sera taken after the onset of infection. no raised serum afp was seen in acute or convalescent sera of 45 patients with other viral diseases, including infectious mononucleosis and acute herpes simplex virus infection. no definite correlation was found between raised afp and raised s-alat values, indicating hepatic damage. the highest single afp values we ... | 1978 | 79217 |
| should renal-transplant patients be screened for c.m.v.? | | 1978 | 80691 |
| immune response of prostatic cancer patients to cytomegalovirus-infected and -transformed human cells. | the indirect immunofluorescent test was used to determine the prevalence of humoral immunity to cytomegalovirus (cmv)-induced antigens in prostatic cancer patients as compared to age-matched controls. significantly more prostatic cancer patients demonstrated high cmv-antibody titers than did the benign prostatic hyperplasia and nonurogenital cancer groups; however, no significant difference in reactivity was found between paients with prostatic cancer and transitional cell carcinoma of the urina ... | 1978 | 81717 |
| igg antibody against early antigen in subclinical congenital cytomegalovirus infection. | | 1979 | 85083 |
| congenital cytomegalovirus infection and diabetes. | | 1979 | 85085 |
| transmission of non-a non-b hepatitis to chimpanzees by factor-ix concentrates after fatal complications in patients with chronic liver disease. | 6 cases of non-a non-b hepatitis which followed administration of four different batches of concentrates of coagulation factor ix from commercial and non-commercial sources are described. of 17 patients who received the concentrate on account of chronic liver disease, 4 developed hepatitis, and in 3 of these the illness proved fatal. the incubation periods ranged from 42 to 103 days (mean 65 days). 3 chimpanzees were inoculated with concentrate from the same batch used on the above patients, a f ... | 1979 | 85107 |
| cytomegalovirus infection and renal transplantation. | | 1979 | 85180 |
| murine model for immunoprophylaxis of cytomegalovirus infection. i. efficacy of immunization. | murine cytomegalovirus was utilized as a model for human cytomegalovirus, which had no experimental animal, to study immunoprophylaxis of the cytomegalovirus infections. (1) murine cytomegalovirus (mcmv) serially propagated in mouse embryonic fibroblasts had lost pathogenicity for weanling mice including neonatally thymectomized mice. (2) the cell culture-adapted mcmv was effective as a "live, attenuated virus vaccine" against challenge by virulent, mouse-passaged mcmv. (3) the immunization via ... | 1978 | 85239 |
| cellular immune response to human cytomegalovirus. i. lymphocyte transformation studies in the rabbit. | the lymphocyte transformation assay was used to monitor the cellular immune response of rabbits sensitized to cytomegalovirus (cmv). peripheral blood lymphocytes from animals inoculated with purified virus were specifically stimulated by crude or twice-banded cmv. blood cells from rabbits immunized to herpes simplex virus type 1 (hsv-1) responded to that antigen but not to cmv. viable or heated cmv preparations stimulated unwashed blood cells as efficiently as washed cells. furthermore, preincub ... | 1979 | 85612 |
| acycloguanosine for viral pneumonia. | | 1979 | 86056 |
| treatment of cytomegalovirus pneumonitis with hyperimmune plasma. | | 1979 | 86057 |
| cytomegalovirus infection and renal transplantation. | | 1979 | 86694 |
| placental fluorescent-antibody studies as test for congenital cytomegalovirus infection. | | 1979 | 86741 |
| vidarabine monophosphate in viral encephalitis. | | 1979 | 86765 |
| neutralization kinetic studies with genital cytomegalovirus isolates, an antigenically variable group. | antisera were prepared in rabbits against four low-passage genital isolates, and against two established strains of human cytomegalovirus. with these sera, and seven strains of virus, 42 virus-antisera combinations were examined by kinetic neutralization procedures, and nk-values derived. no evidence accrued indicating that the five genital isolates constituted an antigenically distinct group. the findings support the view that the human cytomegaloviruses are antigenically heterogeneous, with di ... | 1978 | 87363 |
| possible association of alzheimer's disease with hla-bw15 and cytomegalovirus infection. | | 1979 | 87696 |
| adenovirus infection and heterophile antibody production. | | 1979 | 87716 |
| chlamydia, cytomegalovirus, and yersinia in inflammatory bowel disease. | the relationship of three infectious agents, chlamydia, cytomegalovirus, and yersinia enterocolitica, to the aetiology, clinical course, and diagnosis of crohn's disease was studied. there was no evidence of chlamydial infection in crohn's disease and no indication either that cytomegalovirus alters the outcome of acute attacks or that infection with y. enterocolitica is being misdiagnosed as crohn's disease. | 1979 | 87888 |
| localization of arginine-rich protein in cytomegalovirus dense bodies using phenanthrenequinone fluorescence. | | 1979 | 88802 |
| antigens of human cytomegalovirus: electroimmunodiffusion assay and comparison among strains. | the antigens of strain ad169 of human cytomegalovirus (cmv) were extracted by various methods and at different times following the appearance of cytopathic effects (c.p.e.) in infected fibroblasts. assay with a pooled human serum in electroimmunodiffusion (eid) revealed that the most reactive preparations were obtained by shell-freeze (sf) extraction on the fourth day after 4+c.p.e. as many as 20 antigens could be detected in the original gels, most of which were stable upon storage at 4 degrees ... | 1979 | 90119 |
| association between pre-transplant natural kill and graft-versus-host disease after stem-cell transplantation. | natural killer activity against herpes simplex virus type 1 infected fibroblasts nk(hsv-1) was studied prospectively in patients undergoing allogenic bone-marrow or fetal-tissue stem-cell transplantation. thirteen patients showed evidence of engraftment and survived long enough to develop graft-versus-host disease (gvhd). of this group, all of the seven having normal nk(hsv-1) activity before transplantation acquired gvhd and the six having low nk(hsv-1) had no evidence of gvhd. these results we ... | 1979 | 91840 |
| cytomegalovirus strain differentiation by dna restriction analysis. | the heterogeneity of cmv dna obtained from standard strains and new isolates, including a vaccination strain (towne 125), was investigated. the cleavage patterns produced by the restriction endonucleases eco ri and bam 1 revealed stable strain specificities of cmv. on the other hand, a remarkable homology of sequence-specific cmv dna fragmentation was demonstrated. a cmv subtyping relevant to clinical questions seems to be improbable. | 1979 | 92777 |
| adenine arabinoside monophosphate in experimental vaccinia virus infections. | | 1979 | 93408 |
| immune response to herpesvirus antigens in adults with acute cytomegaloviral mononucleosis. | the immune response of eight patients with mononucleosis caused by cytomegalovirus (cmv) was measured early in their illness--when virus was present in their urine and/or blood--and subsequently during convalescence. levels of cmv-specific antibody rose early in the illness, but the proliferative response of mononuclear cells to cmv antigen did not reach the level characteristic of cmv-immune donors until several months later. the production of interferon by mononuclear cells in response to cmv ... | 1979 | 94336 |
| cytomegalovirus in adults. | | 1977 | 95738 |
| liver disease in patients undergoing hemodialysis and kidney transplantation. | liver dysfunction was observed in 33% of patients treated by hemodialysis and kidney transplantation. fifty-eight percent of these cases of hepatitis occurred in patients with past or present hbs antigenemia, and 77% of hbsag-positive patients showed evidence of ld. however, during the course of a program conducted from 1969 to 1976 and involving 267 patients, the decrease in the prevalence of hbs antigenemia observed during the last two years did not lead to any reduction in ld incidence. in a ... | 1979 | 115244 |
| production of cells and viruses in a new multiple-tube tissue culture propagator. | a novel method for large-scale culture of anchorage-dependent cells is described. culture vessels were constructed by using roller bottles and pyrex tubing. parallel glass tubes, equally spaced by silicone rings and inserted into the roller bottles, provided an increased culture area. the roller bottles were fitted with a second opening for medium recirculation. culture vessels of 1,000-, 4,000-, 8,000- and 16,000-cm2 growth area were constructed to propagate vero, bs-c-1, primary chicken embryo ... | 1979 | 115897 |
| depressed lymphocyte responsiveness in autistic children. | although there are associations linking autism with prenatal rubella, cytomegalovirus, syphilis, and varicella, the etiology of the autistic state remains obscure. host defense against the etiologic agents postulated to be responsible for the autism-associated syndromes is believed to be primarily of the cell-mediated type. in this preliminary study, cellular immune function was assessed in vitro by phytohemagglutinin (pha) stimulation of lymphocyte cultures. twelve autistic children and 13 cont ... | 1977 | 139400 |
| prune-belly syndrome associated with potter (renal nonfunction) syndrome. | three fatal cases of prune-belly syndrome were associated with nonrenal features of potter syndrome. the abdominal muscle hypoplasia is thought to be a result of large kidneys compression the developing abdominal musculature during a critical phase of fetal development. thus, potter syndrome and prune-belly syndrome may coexist when nonfunctioning large kidneys result in oligohydramnios. a teratogenic role of cytomegalovirus inclusion disease and other viruses is possible in the pathogenesis of ... | 1977 | 141205 |
| pathogens, their sources and control--part two. | | 1975 | 162781 |
| [cytomegalic inclusion disease associated with renal abnormalities, pertussis syndrome and hematologic changes]. | | 1975 | 162794 |
| letter: nodular densities in lung. | | 1975 | 162805 |
| [thrombocytopenia caused by cytomegalovirus infection]. | | 1975 | 162807 |
| a study on the correlation between cervical cytomegaloviral infections and venereal disease. | | 1975 | 162917 |
| [mucolipidosis type ii (i-cell disease)]. | | 1975 | 163018 |
| reassembly of tmv 20-s protein disks with 3-s rna fragments. | | 1975 | 163044 |
| fractionation of cucumber mosaic virus rna and its translation in a wheat embryo cell-free system. | | 1975 | 163049 |
| the effect of supraoptimal temperature on the multiplication of different cytomegalovirus strains. | the virion synthesis by five human cytomegalovirus (cmv) strains in human embryonic fibroblast cultures was stopped by incubation of the infected cultures at 40 degrees c. at this temperature the antigens appeared diffusely filling the nucleus and the cytoplasm. the blocking effect of the elevated temperature was exerted in the same period of the reproduction cycle as the inhibitory effect of cytosine arabinoside (ara-c). in cell cultures infected with cmv and incubated first at 40 degrees c, th ... | 1975 | 163057 |
| antiviral drugs for the neonate--the risk-benefit ledger. | | 1975 | 163110 |
| elevated immunofluorescence antibody titers to several herpesviruses in burkitt's lymphoma patients: are high titers unique? | antibody titers for viral capsid antigens of all four human herpesviruses were measured by immunofluorescence in the sera of 16 burkitt's lymphoma (bl) patients, 16 age-, sex-, and locality-matched controls, and 136 family members from the west nile district of uganda. among family members, titers greater than 1:4 were found in 98% for herpes simplex virus (hsv), 86% for varicella-zoster virus (vzv), 100% for cytomegalovirus (cmv), and 94% for epstein-barr (ebv). titers in patients averaged appr ... | 1975 | 163324 |
| human cytomegalovirus stimulates host cell rna synthesis. | human cytomegalovirus infection of human fibroblast cells (wi-38) induced cellular rna synthesis. the rna synthesis in infected cultures preceded the synthesis of viral dna and progeny virus by approximately 24 h. rna species synthesized in infected cells included ribosomal 28s and 18s; and 4s transfer rna; all were markedly increased in comparison to uninfected cells. this induction of host cell rna synthesis was dependent upon a protein(s) that was synthesized during the early stages of infect ... | 1975 | 163357 |