| hazards from simian herpes viruses: reactivation of skin lesions with virus shedding. | a new simian herpes virus with biological properties similar to herpes simplex and to simian "b" virus has been used as a model system for studying virus latency in dorsal root spinal sensory ganglia. following intradermal injection, virus is present in the skin lesions and corresponding ganglia only, during the acute stage of the disease. by organ-culture techniques, latent virus was rescued from ganglia up to 2 years later. no latent virus was ever found in skin organ cultures of the primar ... | 1975 | 47078 |
| mitochondrial and herpesvirus-specific deoxypyrimidine kinases. | to characterize and compare the thymidine (tdr) and deoxycytidine (cdr) kinase isozymes of uninfected and herpesvirus-infected cells: (i) the subcellular distribution of the isozymes has been studied; (ii) a specific assay for cdr kinase has been devised; (iii) the tdr kinase isozymes have been partially purified; and (iv) the purified enzymes have been analyzed by disc polyacrylamide gel electrophoresis, isoelectric focusing, and glycerol gradient centrifugation and by substrate competition and ... | 1975 | 169387 |
| fatal herpesvirus tamarinus infection in cotton-topped marmosets (saguinus oedipus). | fatal herpesvirus tamarinus infection was observed in cotton-topped marmosets (saguinus oedipus) imported from south america via the united states on august 26, 1976. in addition to the lesions hitherto reported in herpesvirus tamarinus infection, severe degenerative and necrotic changes of ganglion cells were recognized with intranuclear inclusion bodies in the plexus of the digestive tract and the sympathetic nerves and their ganglions in the abdominal cavity. inflammatory or regressive change ... | 1979 | 230986 |
| a gene for dihydrofolate reductase in a herpesvirus. | the enzyme dihydrofolate reductase (dhfr) is found ubiquitously in both prokaryotes and eukaryotes. it is essential for de novo synthesis of purines and of deoxythymidine monophosphate for dna synthesis. among viruses, however, only the t-even and t5 bacteriophage have been found to encode their own dhfr. in this study a gene for dhfr was found in a specific subgroup of the gamma or lymphotropic class of herpesviruses. dna sequences for dhfr were found in herpesvirus saimiri and herpesvirus atel ... | 1988 | 2830673 |
| resistance to mutagenesis of cells biochemically transformed by herpesvirus dna fragments. | lm(tk-) mouse fibroblast cells that were biochemically transformed to the dthd kinase-positive phenotype by restriction nuclease fragments of herpes simplex virus or marmoset herpesvirus dna, all of which contained the virus dthd kinase coding region, or by hela s3 dna were more resistant to mutagenesis by n-methyl-n'-nitro-n-nitrosoguanidine or 5-bromodeoxyuridine than were dthd kinase-positive lm and lm(tk-) cells. measurements of dntp pool sizes did not reveal relative imbalances for represen ... | 1985 | 3002361 |
| genome isomerism in two alphaherpesviruses: herpesvirus saimiri-1 (herpesvirus tamarinus) and avian infectious laryngotracheitis virus. brief report. | genome isomerism of avian infectious laryngotracheitis virus (ilt) and herpesvirus saimiri-1 (hvs-1) (formerly h. tamarinus) was investigated using restriction endonuclease analysis and scanning densitometry. ilt dna was found to have 2 isomers with a molecular weight of 109 x 10(6). hvs-1 dna was found to have four isomers with a molecular weight of 102 x 10(6). | 1987 | 3030241 |
| characterization of four herpesviruses isolated from owl monkeys and their comparison with herpesvirus saimiri type 1 (herpesvirus tamarinus) and herpes simplex virus type 1. | four herpesviruses were previously isolated from four outbreaks of lethal disease in owl monkeys. all four isolates have been shown to be antigenically closely related to each other and to herpesvirus saimiri 1 (hvs-1) by kinetic neutralizations. the owl monkey strains also share similarities to hvs-1 and to each other with respect to host range, growth cycles and molecular weights of peptides and of dna fragments generated by restriction endonuclease (r.e.) digestion. r.e. analysis, however, ca ... | 1987 | 3036914 |
| histopathologic changes and specific immunofluorescence in infant mice infected with herpesvirus tamarinus. | | 1971 | 4105417 |
| [on antigen relationship between herpes simplex virus, herpes virus platyrrhinae (marmoset herpesvirus) and equine abortion virus]. | | 1969 | 4318305 |
| occurrence of a carrier state for herpesvirus tamarinus in marmosets. | the ecology of herpesviruses in marmosets and other nonhuman primates is important today, for colonies of these animals are being established for biomedical research. this paper presents the first reported isolations of herpesvirus tamarinus from throat swabs of a healthy white-lipped marmoset carrier (saguinus nigricollis) during a 2-month period. infectivity studies with this virus in both white-moustached (s. mystax) and white-lipped marmosets demonstrated that the virus is not lethal to whit ... | 1971 | 4322280 |
| antigenic relationships among four herpesviruses. | common viral antigens were detected, by fluorescent-antibody studies, in cells infected with herpes simplex virus 1, squirrel monkey herpesvirus 1, bovine rhinotracheitis, and equine abortion viruses. the two primate viruses showed slight cross-neutralization. | 1973 | 4351969 |
| biochemical transformation of mouse cells by a purified fragment of marmoset herpesvirus dna. | although the size of marmoset herpesvirus (marhv) dna, estimated by velocity sedimentation in sucrose gradients, was similar to that of herpes simplex virus type 1 (hsv-1) dna, the restriction endonuclease sites of marhv and hsv-1 dnas were quite different. a specific bamhi restriction fragment (6.2 x 10(6) daltons) of marhv dna biochemically transformed lm(tk-) mouse fibroblasts to the thymidine kinase(tk)-positive phenotype. rabbit antisera, prepared against marhv tk, inhibited marhv-induced t ... | 1980 | 6154671 |
| inhibition by interferon of biochemical transformation induced by cloned herpesvirus thymidine kinase genes. | to learn whether interferon could prevent the biochemical transformations induced by cloned herpesvirus thymidine kinase (tk) genes, lm(tk-) mouse fibroblast cultures were pretreated for 24 h with 2.4-40 international units (i.u.)/ml mouse alpha + beta interferon, and subsequently transformed to the tk+ phenotype with recombinant plasmids containing the herpes simplex virus type 1 (hsv-1) tk gene (pago and pmh110) and the marmoset herpesvirus (marhv) tk gene (pmar035). mouse alpha + beta interfe ... | 1982 | 6185091 |
| morphological observations of the replication of herpesvirus tamarinus in rl-33 cells. | the replication in rl-33 cells (rabbit lung cell line) of herpesvirus tamarinus isolated from cotton-topped marmosets (saguinus oedipus) was investigated by electron microscopy. in the early stages of infection, ring-shaped and granular structures, and fibrillar materials were recognized in the nucleus. immature particles were often found in such nuclei. the envelope of the virus was formed by budding through intracytoplasmic membranes, the inner nuclear membrane or the membrane of intracytoplas ... | 1980 | 6254473 |
| cloning of the marmoset herpesvirus thymidine kinase gene and analyses of the boundaries of the coding region. | | 1981 | 6267782 |
| herpesvirus tamarinus and its relation to herpes simplex virus. | we have characterized herpesvirus tamarinus (ht), a virus of new world primates related to herpes simplex virus. ht virion dna cross-hybridized appreciably with herpes simplex virus type 1 (hsv-1) dna. the ht-hsv-1 cross-hybridizing dna sequences were distributed over the length of the genome; some dna sequences, however, were apparently more homologous than others. ht virion dna was estimated from the sum of restriction endonuclease fragments to have a mol. wt. 98 x 10(6). only 1 molar fragment ... | 1981 | 6271910 |
| fatal herpesvirus tamarinus infection in cotton-topped marmosets (saguinus oedipus). | | 1981 | 6275150 |
| attenuated marmoset herpesvirus isolated from recombinants of virulent marmoset herpesvirus and hybrid plasmids. | marmoset herpesvirus (marhv) deletion mutants in the thymidine kinase (tk) gene were isolated after infection of omk cells with tk+ marhv dna and the hybrid plasmid, pmar401, which lacks a 2.6-kb kpni-m fragment in the coding region of the marhv tk gene. after plaque purification in tk- hela(bu25) cells, the dna's from five recombinant arat-resistant marhv clones were analyzed with restriction nucleases to verify that the 2.6-kb kpni-m fragment (and a 0.9-kb bglii-q fragment) were deleted from t ... | 1983 | 6311965 |
| nucleotide sequence of the marmoset herpesvirus thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide. | the nucleotide sequence of a 2549-bp dna fragment containing the entire coding region of the marmoset herpesvirus (marhv) thymidine kinase gene (tk) and the flanking sequences was determined by the dideoxynucleotide chain termination method. the marhv thymidine kinase polypeptide predicted from the nucleotide sequence contained 376 amino acids and had a molecular weight of 41,281. the sequencing data also reveal that the coding portion of another marhv gene probably begins only 292 nucleotides d ... | 1984 | 6330976 |
| sequence analysis of herpes simplex virus gb gene homologs of two platyrrhine monkey alpha-herpesviruses. | homologs of the herpes simplex virus gb gene were identified in two alpha-herpesviruses of platyrrhine monkeys, herpesvirus saimiri 1 (hvs 1) and h. ateles 1 (hva 1). these genes were cloned and sequenced in their entirety. analysis of the predicted amino acid sequences indicated that the gb glycoproteins of these two viruses are of similar size, have 10 cys residues and 5 potential n-linked glycosylation sites which align exactly with those in other primate alpha-herpesvirus gb polypeptides, an ... | 1993 | 8385913 |
| characterization of gross and histological lesions in balb/c mice experimentally infected with herpesvirus saimiri 1 (hvs1). | accidental b virus (herpesvirus simiae) infection of human beings working with macaques is frequently fatal. however, the pathogenic potential of other similar simian alphaherpesviruses, such as the squirrel monkey virus herpesvirus saimiri (hvs1), is virtually unknown. as part of an effort to develop a murine model for infections with these agents, balb/c mice were inoculated intramuscularly in the left hindlimb with 10 to 10(6) plaque forming units (pfu) of hvs1. after observation for clinical ... | 2001 | 11437513 |
| expression of the simian epstein-barr virus-encoded latent membrane protein-1 in malignant lymphomas of siv-infected rhesus macaques. | during the course of simian immunodeficiency virus (siv) infection, nearly 15% of rhesus macaques (macaca mulatta) and up to 40% of cynomolgus macaques (macaca fascicularis) developed siv-associated non-hodgkin's lymphomas. most of these malignant lymphomas harbored lymphocryptoviruses, which are closely related to the human epstein-barr virus (ebv; herpesvirus m. mulatta and herpesvirus m. fascicularis). to characterize the oncogenic role of simian ebv infection for lymphomagenesis during siv i ... | 2001 | 11505452 |
| construction and in vivo detection of an enhanced green fluorescent protein-expressing strain of saimiriine herpesvirus 1 (sahv-1). | saimiriine herpesvirus 1 (sahv-1) is an alpha-herpesvirus of squirrel monkeys used in mice to study neural pathogenesis of herpesviruses. to trace dissemination of virus from a peripheral site of inoculation to the central nervous system tissues, a recombinant strain of sahv-1 expressing enhanced green fluorescent protein (gfp) was constructed by site-specific insertion of a gfp expression cassette into a transcriptionally null point in the sahv-1 genome. pcr and southern blot confirmed insertio ... | 2003 | 12556995 |
| temporal progression of viral replication and gross and histological lesions in balb/c mice inoculated epidermally with saimiriine herpesvirus 1 (sahv-1). | saimiriine herpesvirus 1 (sahv-1), an alphaherpesvirus enzootic in squirrel monkeys, is genetically related to monkey b virus and human herpes simplex virus (hsv). to study the temporal progression of viral spread and associated lesions, balb/c mice were inoculated epidermally by scarification with a green fluorescent protein (gfp)-expressing recombinant strain of sahv-1 and killed sequentially. pinpoint ulcerative lesions in the inoculated epidermis progressed over a few days to unilateral or b ... | 2005 | 15964589 |
| structure and sequence of the saimiriine herpesvirus 1 genome. | we report here the complete genome sequence of the squirrel monkey α-herpesvirus saimiriine herpesvirus 1 (hvs1). unlike the simplexviruses of other primate species, only the unique short region of the hvs1 genome is bounded by inverted repeats. while all old world simian simplexviruses characterized to date lack the herpes simplex virus rl1 (γ34.5) gene, hvs1 has an rl1 gene. hvs1 lacks several genes that are present in other primate simplexviruses (us8.5, us10-12, ul43/43.5 and ul49a). althoug ... | 2010 | 21130483 |
| a functional interaction between herpes simplex virus 1 glycoprotein gh/gl domains i and ii and gd is defined by using alphaherpesvirus gh and gl chimeras. | whereas most viruses require only a single protein to bind to and fuse with cells, herpesviruses use multiple glycoproteins to mediate virus entry, and thus communication among these proteins is required. for most alphaherpesviruses, the minimal set of viral proteins required for fusion with the host cell includes glycoproteins gd, gb, and a gh/gl heterodimer. in the current model of entry, gd binds to a cellular receptor and transmits a signal to gh/gl. this signal then triggers gb, the conserv ... | 2015 | 25926636 |
| substitution of herpes simplex virus 1 entry glycoproteins with those of saimiriine herpesvirus 1 reveals a gd-gh/gl functional interaction and a region within the gd profusion domain that is critical for fusion. | to gain insight into the mechanism of herpesvirus entry into cells, the four glycoproteins that are necessary for herpes simplex virus (hsv) fusion were cloned from the saimiriine herpesvirus 1 (sahv-1) genome, a primate member of the alphaherpesvirus family. cell-cell fusion assays indicate that sahv-1 entry glycoproteins function with the previously identified alphaherpesvirus entry receptors nectin-1 and cd155 but not with herpesvirus entry mediator (hvem) or paired immunoglobulin-like type 2 ... | 2014 | 24672037 |
| data on meq gene sequence analysis of ludhiana mdv isolates. | the data described are related to the article entitled "sequence analysis of meq oncogene among indian isolates of marek׳s disease herpesvirus" m. gupta, d. deka, ramneek, 2016. seven meq genes of ludhiana marek׳s disease virus (mdv) field isolates were pcr amplified by using proof reading platinum pfx dna polymerase enzyme, sequenced and then analyzed for the distinct polymorphisms and point mutations. the sequences were named as ldh 1758, ldh 2003, ldh 2483, ldh 2614, ldh 2700, ldh 2929 and ld ... | 2016 | 27656677 |