| letter: live varicella vaccine. | | 1975 | 46043 |
| is varicella virus teratogenic. | | 1977 | 64879 |
| detection of antibodies to varicella zoster virus by radioimmunoassay and enzyme immunoassay techniques. | an enzyme assay for the detection of antibodies to varicella-zoster membrane antigen (ipama) and a solid phase radioimmunoassay (ria) which utilizes infected cell lysates as antigen are described. the results have been compared with those obtained by the indirect fluorescent antibody to membrane antigen (ifama) technique. it was found that ipama was equal in sensitivity to ifama. no cross-reactivity was found with other herpes group viruses. the ipama appears to give objective results, is easily ... | 1978 | 82905 |
| treatment of chickenpox pneumonia with adenine arabinoside. | | 1979 | 86115 |
| antibody to early antigens of varicella-zoster virus during varicella and zoster. | igg antibody to the early antigens of varicella-zoster virus (vzv) was studied during both varicella and zoster by the indirect immunoperoxidase antibody technique. in parallel, complement-fixing, immune-adherence hemagglutinating, igg, and igm antibodies to vzv were studied. in both varicella and zoster infections, antibody to the early antigens of vzv appeared three to five days after onset of infection, reached a peak during the second week, and progressively decreased in titer until it disap ... | 1979 | 88490 |
| immune response to herpesvirus antigens in adults with acute cytomegaloviral mononucleosis. | the immune response of eight patients with mononucleosis caused by cytomegalovirus (cmv) was measured early in their illness--when virus was present in their urine and/or blood--and subsequently during convalescence. levels of cmv-specific antibody rose early in the illness, but the proliferative response of mononuclear cells to cmv antigen did not reach the level characteristic of cmv-immune donors until several months later. the production of interferon by mononuclear cells in response to cmv ... | 1979 | 94336 |
| elevated immunofluorescence antibody titers to several herpesviruses in burkitt's lymphoma patients: are high titers unique? | antibody titers for viral capsid antigens of all four human herpesviruses were measured by immunofluorescence in the sera of 16 burkitt's lymphoma (bl) patients, 16 age-, sex-, and locality-matched controls, and 136 family members from the west nile district of uganda. among family members, titers greater than 1:4 were found in 98% for herpes simplex virus (hsv), 86% for varicella-zoster virus (vzv), 100% for cytomegalovirus (cmv), and 94% for epstein-barr (ebv). titers in patients averaged appr ... | 1975 | 163324 |
| the densities of herpesviral dnas. | | 1975 | 164053 |
| the varicella-zoster virus in the etiology of severe congenital defects. a survey of eleven reported instances. | | 1975 | 165028 |
| effect of human leukocyte interferon on vaccinia-and herpes virus-infected cell cultures and monkey corneas. | pretreatment of human fibroblast cultures with human leukocyte interferon (hif, 1,000 iu/ml) resulted in a 24-h delay of virus replication after infection with vaccinia virus and herpes simplex virus type 1 and type 2. additional hif treatment 24 h after infection effectively lowered the maximum yield of viral infectivity. equal results were obtained in simian cells with 3,000 iu of hif per ml. the spread of two cell-bound herpesviruses, varicella zoster virus and medical lake macaque herpesviru ... | 1975 | 166924 |
| herpes simplex virus in idiopathic facial paralysis (bell palsy). | sera from all 41 adult patients with idiopathic facil paralysis (bell palsy) and 35 (85%) of 41 matched controls who had never had bell palsy contained antibodies to herpes simplex virus (p smaller than.05). the frequency of antibodies to herpes zoster virus did not differ in patients and controls. a rise in antibody titer, indicating primary herpes simplex virus infection, was not found in these patients. that bell palsy may be caused by reactivation of herpes simplex virus is suggested by (1) ... | 1975 | 167209 |
| the ultrastructure of disrupted herpesvirus nucleocapsids. | | 1975 | 167517 |
| development of a live attenuated varicella vaccine. | the oka strain of varicella virus, isolated in our labolatory, was serially cultivated in guinea-pig embryo cultures (gpec), and a considerable amount of cell-free virus was obtained from infected cell. gpec passage virus at the 6th passage level was used in a small scale field trial. susceptible children of 1 to 10 years old were injected subcutaneously with 100 to 1,000 pfu of virus. no clinical reactions due to the vaccination were observed in any children, and a high rate of antibody respons ... | 1975 | 167707 |
| application of a live attenuated varicella vaccine to hospitalized children and its protective effect on spread of varicella infection. | twenty-three hospitalized children with no history of varicella or no detectable complement fixing (cf) antibody, were vaccinated with a live attenuated varicella vaccine (oka strain) immediately after the occurrence of a case of varicella in a children's ward of hospital. these children suffered from the nephrotic syndrome, nephritis, purulent meningitis, hepatitis etc., and 12 of them were receiving steroid therapy. an antibody response was noticed in all the vaccinated children, with mild fev ... | 1975 | 167708 |
| detection of viral cores having toroid structures in eight herpes viruses. | | 1975 | 167709 |
| immunological relationship between delta herpesvirus of patas monkeys and varicells-zoster virus of humans. | the delta herpesvirus (dhv) which produced outbreaks of exanthematous disease in patas monkeys was shown to have a close immunological relationship to varicella-zoster (v-z) virus of man. immunization of rhesus monkeys with dhv or v-z virus resulted in the development of neutralizing antibodies to both viruses and also in the production of complement-fixing antibodies to v-z virus. immunoglobulin m neutralizing antibody to v-z virus was demonstrated in the serum of a rhesus monkey immunized with ... | 1975 | 168152 |
| [virus propagation, virus replication and virus elimination in the human skin in zoster]. | the purpose of this study was to investigate the spreading, the replication and the elimination of varicella-zoster-virus (zv) in human skin. typical skin lesions of thoracic zoster in different stages of development and of exanthematic vesicles in ophthalmic zoster were examined under the electron microscope. we found that zv may be detected in fully developed vesicular skin lesions only, whereas in immature lesions and in the surrounding non involved skin axonal alterations may be seen, with n ... | 1975 | 168168 |
| [letter: isolation of zoster patients]. | | 1975 | 168169 |
| letter: possbile relation between herpes simplex and zoster. | | 1975 | 168491 |
| investigations on the properties of established cell lines of human and animal origin to induce cartilage and bone and properties of human fibroblasts transformed by varicella virus. | | 1975 | 167238 |
| unusual infections of the nervous system in malignant lymphomas. | infection of the nervous system by toxoplasma, cytomegalovirus and varicella-zoster virus is described in three adult patients with malignant lymphoma. morphologic identification of these organisms in otherwise nonspecific lesions is emphasized. since such intercurrent infections are not usually diagnosed clinically in debiliated patients, their recognition at autopsy is important, particularly in view of the wide spread distribution of these organisms in normal population. | 1975 | 169666 |
| clinical aspects of viral infections in kidney-graft recipients. | | 1975 | 170042 |
| varicella-zoster virus and subcutaneous cytarabine: correlation of in vitro sensitivities to blood levels. | the susceptibility of 26 strains of varicella-zoster virus to cytarabine was tested in vitro by measuring reduction in number and size of plaques using human foreskin fibroblast cells. most strains showed 50% reduction of plaque number by 0.125 mug of cytarabine per ml or less. cytarabine levels in sera of 12 patients after a single subcutaneous injection of 50 mg/m(2) exceeded this inhibitory level for a period of 75 min. thus, the subcutaneous route is a potentially useful method of administra ... | 1975 | 166610 |
| vaccination against herpes group viruses. | | 1975 | 170580 |
| vaccination against herpesviruses. | | 1975 | 170581 |
| inconspicuous viral pneumonitis: a potential relationship to evolving emphysema. | | 1975 | 166602 |
| epidemiology of cytomegalovirus infection after transplantation and immunosuppression. | viral infections and clinical complications were studied during hemodialysis and after renal transplantation. active cytomegalovirus infection developed in 96% of patients after renal transplantation; reactivation of herpes simplex, varicella-zoster, and epstein-barr viruses was found in 35%, 24%, and 0% of patients, respectively. cytomegalovirus viremia developed in 42% of patients an average of two months after renal transplantation, lasted 1.75 (+/- 1.5) months (except in one patient with chr ... | 1975 | 171315 |
| should patients with zoster receive zoster immune globulin? | zoster developed in 55 patients, and 15, generalized disease occurred. twelve of 14 patients with dissemination had prompt appearance of both complement-fixing (cf) antibody and fluorescent antibody against varicella-zoster (vs) membrane antigen (fama). the geometric mean titers of vz antibody from the first to the fifth and the sixth through the tenth days following onset of zoster were similar in patients with localized and generalized involvement. two patients with disseminated zoster had und ... | 1975 | 171458 |
| [letter: immunization against varicella (the priority of pál ferencz)]. | | 1975 | 172830 |
| ineffectiveness of subcutaneous cytosine arabinoside in localized herpes zoster. | cytosine arabinoside (cytarabine) was evaluated in a randomized double-blind controlled study for the treatment of localized herpes zoster. cytarabine was administered subcutaneously in a dose of 50 mg/m-2 body surface area once daily for 4 days, always within 14 days of onset of the first symptom and usually within 7 days. thirty patients given cytarabine and 30 patients given placebo were well matched with respect to age, sex, and length and severity of presenting rash and pain as well as unde ... | 1975 | 166586 |
| an immunofluorescence technique with counterstain on fixed cells for the detection of antibodies to human herpesviruses; antibody patterns in patients with hodgkin's disease and nasopharyngeal carcinoma. | an indirect immunofluorescence (if) test on fixed cells with evans' blue counterstain is described for all four human herpesviruses, i.e., herpes simplex virus type 1 and type 2 (hsv-1 and hsv-2), varicella-zoster virus (vzv), cytomegalovirus (cmv) and epstein-barr virus (ebv). comparison with immunodiffusion (id) for hsv-2 and with id and complement fixation (cf) for vzv and cmv demonstrated the specificity and high sensitivity of the if test. also introduced is a modification of the anti-compl ... | 1976 | 67099 |
| in vitro antiherpetic activity of water-soluble amphotericin b methyl ester. | | 1975 | 173265 |
| treatment of varicella-zoster virus infections with adenine arabinoside. | twenty-three patients with complicated varicella-zoster virus infections were treated with adenine arabinoside. of 14 patients with herpes zoster, 13 had malignancy treated with irradiation and cytotoxic agents or steroids. although the duration of active vesicle formation in these patients ranged from two to 14 days before therapy, no new lesions appeared after the fourth day of treatment with adenine arabinoside. zoster encephalitis developed in one patient on the third day of treatment, and s ... | 1975 | 165242 |
| virus infections in renal transplant recipients. | 534 serum samples from 73 renal transplant recipients, 41 haemodialysis patients, and 99 blood and organ donors were examined serologically for antibodies against cytomegalo, h. simplex (types 1 and 2), varicella-zoster, epstein-barr, adeno, influenza, parainfluenza, respiratory syncytial, measles, picorna- and human polyoma- viruses. serum specimens were stored in the lyophilized state until examined thus enabling a simultaneous testing of all samples belonging to one patient. all antigens, com ... | 1975 | 126545 |
| herpes zoster of the maxillary branch of the trigeminus nerve. virological and serological studies. | a 70-year-old male had erythematous and vesiculous lesions in the area of the right maxillary branch of the trigeminus nerve and was clinically diagnosed as having herpes zoster; virological and serological investigations of this case were carried out. consequently, an electron microscopic observation revealed a great number of virus particles of herpes type in the vesiculous lesion and in baby hamster kidney bhk21/wi-21 cells, cultured after inoculating the fluid from the vesicle formed on the ... | 1979 | 112072 |
| testing the properties of an experimental batch of zoster immune gammaglobulin (zig). | the methods of indirct haemagglutination (ih) and precipitation in gel (id) were employed to test the level of varicella-zoster (vz) antibodies in an experimental batch of zoster gammaglobulin (zig). the titre of indirect haemagglutinating antibodies in zig was about 64 times higher than in the ordinary batches of normal immunoglobulin and about 8 times higher in comparison with the level of the initial plasma pool. in the reaction of precipitation in gel, zig produced 5 to 6 zones. in compariso ... | 1979 | 93127 |
| specificity of the blastogenic response of human mononuclear cells to herpesvirus antigens. | peripheral blood mononuclear (pbm) cells from donors with a history of prior infection with herpes simplex virus, varicella-zoster virus, and/or cytomegalovirus were cultured for 2 to 8 days with glycine-extracted antigens prepared from these viruses and from infectious bovine rhinotracheitis virus. the proliferative response of pbm cells from all donors was specific during the first 6 days in culture. during this period the cellular immune responses of the seronegative donors were clearly diffe ... | 1978 | 78901 |
| cellular events in zoster vesicles: relation to clinical course and immune parameters. | the cellular responses in zoster vesicles was studied chronologically in 30 patients, some of whom were compromised hosts with disseminated disease. cell counts were low initially but rose abuptly later. polymorphonuclear leukocytes predominated at all times in the vesicular fluid and in the cells adherent to the vesicle base. the abrupt rise in the number of cells generally coincided with an abrupt rise in the titer of vesicular interferon; both increases preceded resolution of local infection ... | 1975 | 165243 |
| [seroepidemiological study of varicella-zoster virus by complement fixation reaction]. | | 1975 | 165248 |
| partial characterization of a soluble antigen preparation from cells infected with human cytomegalovirus: properties of antisera prepared to the antigen. | soluble antigen (sa) preparations were obtained from cell cultures infected with either the davis or ad169 strains of cytomegalovirus (cmv). fractionation of sa preparations through sephadex g-200 resulted in a molecular weight value ranging from 67,000 to 85,000. rate-zonal centrifugation produced an approximate value of 5.5s for the cmv antigenic material. antisera to sa prepared from either ad169- or davis-infected cells lacked neutralizing activity but produced specific fluorescence confined ... | 1975 | 164507 |
| [immunologic status in hodgkin patients: correlation with epstein-barr virus titers]. | 1. in hodgkin's disease patient's immunological in vitro and in vivo parameters are of prognostic importance. 2. skin test reactivity correlates to peripheral t-lymphocyte counts and con a induced lymphoblastogenesis. 3. con a is the most sensitive in vitro indicator for detecting latent immunodeficiency. 4. hodgkin patients in long term remission after tumor reductive therapy exhibit a qualitative and quantitative lymphocyte defect. 5. in hodgkin patients herpes virus related antibody titers ar ... | 1976 | 177135 |
| meningitis associated with herpes zoster. immunofluorescent demonstration of varicella-zoster antigens in csf cells. | | 1976 | 61267 |
| letter: contact infection from live varicella vaccine recipients. | | 1976 | 57366 |
| adenine arabinoside therapy of herpes zoster in the immunosuppressed. niaid collaborative antiviral study. | we evaluated adenine arabinoside treatment of herpes zoster in immunodeficient patients in a randomized, controlled crossover study. the two study groups had similar characteristics. in spite of rapid natural healing, those receiving adenine arabinoside over the first five days had accelerated clearance of virus from vesicles (p = 0.01), and cessation of new vesicle formation (p = 0.004), and a shorter time to total pustulation (p = 0.001). factors modifying the response to therapy included age, ... | 1976 | 177866 |
| a case of peripheral facial palsy following varicella. | | 1975 | 51052 |
| use of live varicella vaccine in children with acute leukaemia or other malignancies. | | 1976 | 73844 |
| varicella-zoster ophthalmicus. | | 1975 | 178619 |
| prophylaxis of varicella in children with neoplastic disease: comparative results with zoster immune plasma and gamma globulin. | the incidence and severity of varicella following a close family contact were evaluated in children with neoplastic diseases who received prophylaxis either with commerical gamma globulin or with zoster immune plasma, as compared to patients who did not receive any prophylaxis. in the untreated group, all 14 patients developed varicella, complicated by 1 case of encephalitis and 2 cases of fatal pneumonia. in the group of 17 patients who received 0.6-1.2 ml/kg body weight of gamma globulin, 16 d ... | 1975 | 46775 |
| reactivation of varicella virus in trigeminal ganglion. | | 1976 | 63028 |
| deoxypyrimidine nucleoside metabolism in varicella-zoster virus-infected cells. | noninfected and varicella-zoster virus (vzv)-infected human foreskin fibroblasts were examined for thymidine kinase activity. the specific activity of vzv-infected cell extracts was approximately 7.5-fold greater than that of mock-infected cells and 3-fold greater than that of actively growing cells. the ph optimum of vzv-infected cell thymidine kinase activity was found to be 8.0, whereas thymidine kinase activity in noninfected cells exhibited a sharp ph optimum at 7.4. electrophoretic analysi ... | 1978 | 24124 |
| varicella-zoster virus-induced dna polymerase. | nuclear extracts of varicella-zoster virus (vzv)-infected human embryo lung (hel) cells were found to contain dna polymerase activity not present in uninfected hel cells. this enzyme was designated the vzv-induced dna polymerase. the vzv-induced polymerase was partially separated from the cellular alpha- and beta-polymerases by fractionation of the cells and by phosphocellulose chromatography. the separated enzymes were examined for the effect of added (nh4)2so4, activity with synthetic template ... | 1977 | 21226 |
| diseases associated with herpesviruses. | human herpesviruses have been associated with numerous diseases throughout history (table 3), but their ability to induce latent and recurrent infections, alongwith their oncogenic capabilities, is only beginning to be understood. accordingly, our ability to deal with the diseases induced by herpesviruses is severely limited by our lack of information concerning the basic processes of virus-host cell interactions and systemic host factors; especially immune factors that are involved in the disea ... | 1976 | 179753 |
| varicella-zoster immunoglobulins during varicella, latency, and zoster. | antibodies to membrane antigens of cells infected by varicella-zoster virus were detected by immunofluorescence. rises in varicella-zoster iga, igg, and tigm were detected after both varicella and zoster. prompt antibody responses were observed in patients with generalized zoster as well as in those with localized zoster. a delayed response was found, moreover, in one patient who did not develop disseminated disease. antibody to varicella-zoster virus was detected in the sera of all three patien ... | 1975 | 169308 |
| adenine arabinoside for therapy of herpes zoster in immunosuppressed patients: preliminary results of a collaborative study. | eighty-seven immunosuppressed patients (53 with localized and 34 with disseminated herpes zoster) from 10 institutions were enrolled in a controlled therapeutic trial of adenine arabinoside. a crossover design was employed; thus, 47 patients received drug for five days and then received placebo, and 40 were given the two substances in the opposite order. resolution of acute pain and the cutaneous lesions were graded during a 10-day observation period. during the initial five-day period, treated ... | 1976 | 180198 |
| antiviral activity of a pyrazino-pyrazine derivative. | the 2,3-dihydroxy-6-bromo-pyrazino-[2,3-beta]-pyrazine is a substance selected during the antiviral screening of pyrazino-pyrazine derivatives. the compound shows antiviral activity in vitro against measles, ndv, some influenza viruses and against herpes simplex and zoster, infectious canine hepatitis and vaccinia viruses. it had no effect on echo 9 virus. therapeutic trials showed activity also on herpetic keratoconjunctivitis experimentally induced in rabbits. | 1975 | 169110 |
| neutralizing antibody responses to varicella-zoster virus. | neutralization of varicella-zoster (v-z) virus by human sera and immune rhesus monkey sera was enhanced by fresh guinea pig complement. there was no marked difference in the degree to which complement enhanced neutralization by sera from current v-z virus infections and sera from long-past varicella infections. immunoglobulin g neutralizing antibody in sera from varicella cases was enhanced by complement to a slightly higher degree than was immunoglobulin m (igm) antibody, and immunoglobulin g n ... | 1975 | 170206 |
| severe hemorrhagic varicella with visceral involvement: virological and serological studies during treatment with cytosine arabinoside. | a boy 13 year-old suffered an extremely severe and prolonged attack of hemorrhagic chickenpox with visceral involvement, the diagnosis being confirmed by isolation of varicella-zoster-virus (vzv). there was no other compromising disease. all preceding vaccinations including two against smallpox had been uneventful. the severity of the attack could not be ascribed to any persistent cellular or humoral immunodeficiency. the patient developed a good antibody response. the course of serological reac ... | 1976 | 181329 |
| anti-ebv antibody titers in non-hodgkin lymphomas. | antibody titers to epstein-barr virus (ebv)-related antigens, i.e. viral capsid antigen (vca), the d and r components of the early antigen (ea) complex and the ebv-associated nuclear antigen (ebna), were determined in a series of 86 patients with non-hodgkin lymphomas and in 150 matched control subjects. the lymphoma patients belonged to four histological groups: diffuse, nodular, hyperbasophilic malignant lymphoma (hml) and unclassified. the ebv-related serological data were compared to the inc ... | 1976 | 181335 |
| [encephalitis in the course of varicella in children]. | | 1976 | 181735 |
| [myelocytic leukaemia with atypical evolution (author's transl)]. | a case of myelocytic leukaemia appeared in a four year old boy. the surprisingly benign evolution until now, leds to a speculation on the possible influence exerced by chickenpox virus as a immunologic stimulant. | 1976 | 182048 |
| antibody titers by mixed agglutination to varicella-zoster, herpes simplex and vaccinia viruses in patients with multiple sclerosis. | antibody titers to varicella-zoster (v-z), herpes simplex (hsv) and vaccinia viruses were determined in sera collected in buffalo, ny, from patients with multiple sclerosis (ms), patients with other diseases, and normal individuals. the mixed agglutination test employing cell cultures infected with one of the above viruses as a source of antigen was used to determine antibody titers. the geometric mean titer (gmt) for v-z in 59 ms cases was significantly higher than that observed in patients wit ... | 1975 | 170625 |
| improved yields of cell-free varicella-zoster virus. | systematic studies on the replication of varicella-zoster virus in infected human fetal diploid lung cells have defined more optimal conditions for infection and harvesting of cultures and have led to the production of cell-free virus preparations with infectivity titers of greater than or equal to 10(6) plaque-forming units per ml. the highest yields of cell-free virus were obtained by (i) sonic treatment of the cellular phase of cultures inoculated with trypsin-dispersed infected cells at rati ... | 1976 | 184051 |
| an improved plaque assay for varicella virus. | | 1976 | 184765 |
| indirect microhemagglutination test for varicella--zoster antibody determination. | an indirect microhemagglutination assay (iha) was devised because of a need to provide an alternative test to complement fixation (cf) for varicella-zoster (v-z) antibody determination. human erythrocytes were sequentially treated with 2% glutaraldehyde, 0.04% tannic acid, and 2% pyruvic aldehyde then exposed to sonicated v-z infected cells. this same tanning procedure was suitable for herpes simplex and epstein-barr virus antigen attachment but unsatisfactory for several non-herpes-group viruse ... | 1976 | 184904 |
| seroepidemiologic survey of varicella: value of specific fluorescent antibody test. | the sensitive varicella-zoster fluorescent antibody to membrane antigen (v-z fama) test was used in a seroepidemiologic survey of two outbreaks of varicella involving 30 children. the attack rate of varicella based on clinical observations alone was 60%. the attack rate based on clinical and serological observations lay between 78% and 82%, after excluding those children who had detectable antibody at the time of exposure. no subclinical varicella infection was observed in this small series of p ... | 1975 | 172853 |
| infection of guinea-pig embryo cells with varicella-zoster virus. | varicella-zoster (vz) virus has been shown to replicate in guinea-pig embryo (gpe) cells. when cell-free virus inocula were used, no infectious virus was liberated from these cells, either by freezing-thawing or ultrasonic disruption. however, cell-free virus was separated from gpe cells inoculated with infected human embryonic lung (hel) cells. | 1975 | 172949 |
| pathology of the human spinal ganglia in varicella-zoster virus infection. | spinal ganglia from a patient who died on the 6th day of varicella infection were examined by immunofluorescence and electron microscopy, and were compared with spinal ganglia from a patient dying on the 17th day of herpes zoster infection. in herpes zoster, typical intranuclear inclusion bodies were found in neurons, satellite cells and fibroblast-like cells of the ganglia, which contained numerous naked virus particles. in varicella, few changes were found by light microscopy but viral antigen ... | 1975 | 173126 |
| [study of herpes zoster keratitis; demonstration of virus particles in corneal scrapings (author's transl)]. | | 1975 | 173166 |
| hodgkin's disease and granulomatous angiitis of the central nervous system. | granulomatous angiitis of the central nervous system, a pathologic entity associated previously with a fatal prognosis, is reported in a patient with hodgkin's disease. viral isolation, indirect fluorescent antibody, and electron microscopic studies performed on fresh cerebral tissue were negative. the granulomatous angiitis of the central nervous system in this patient remitted following therapy for hodgkin's disease. the epidemiologic, clinical and pathologic data in all reported cases of gran ... | 1976 | 186177 |
| idoxuridine ocular insert therapy. use in treatment of experimental herpes simplex keratitis. | therapy of acute herpes simplex keratitis in rabbits with idoxuridine-releasing ocular inserts showed that an application rate of 30mug/hr gave significantly better results than conventional treatment with idoxuridine drops and ointment while exposing the eye to 40% less drug. delivery rates lower than this were equal or not as effective as drop and ointment therapy and rates up to 100 mug/hr did not produce significantly better results than rates of 30mug/hr. serial viral cultures demonstrated ... | 1975 | 173270 |
| clinical significance of viral latency. | evidence is accumulating to show that a number of viruses have the ability to adapt to man's defense mechanisms and survive in a latent state for what appears to be the life of the human host. unfortunately, latent viral presence, which may appear clinically benign initally, may manifest itself later as severe and often fatal disease. some members of the herpes virus family have latent potential and are discussed in detail. clinical competence would suggest a thorough understanding of these late ... | 1976 | 186670 |
| the demonstration of cell-associated immunity to viruses. in vitro lymphocyte responsiveness to varicella-zoster antigen. | the demonstration of in vitro lymphocyte responsiveness to common pediatric viruses has previously been fraught with many technical and conceptual problems. based upon our prior experience in demonstrating cell-associated immunity to mumps, rubella and measles viruses we illustrate our methodology and conceptual framework by documenting in vitro lymphocyte responsiveness to the varicella-zoster virus, another ubiquitous virus of childhood. we discuss our approach to the problems of reactivity, s ... | 1976 | 62002 |
| chemotherapy for varicella-zoster infections. | | 1976 | 187277 |
| sensitivity of a radioimmunoassay method for detection of certain viral antibodies in sera and cerebrospinal fluids. | an indirect solid-phase radioimmunoassay (ria) was applied to titration of serum and cerebrospinal fluid (csf) antibodies against a variety of viruses including rubella, mumps, measles, herpes simplex, varicella-zoster, and vaccinia. the test used fixed, virus-infected cells as a source of antigen, and conditions for optimal production of viral antigen were determined for each virus-host cell system. in acute, uncomplicated viral infections, sera taken 2 to 5 days after onset generally had low h ... | 1976 | 187618 |
| analysis of late infections in 89 long-term survivors of bone marrow transplantation. | | 1979 | 34408 |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 9-1976. | | 1976 | 173998 |
| [pathology and pathogenesis of varicella and zoster (author's transl)]. | | 1976 | 189104 |
| the pathogenesis of simian varicella virus in cynomolgus monkeys. | the mlm herpesvirus is infectious for cynomolgus monkeys. the disease in this species, possibly modulated by preinoculation antibody resembles human varicella. virus has been recovered from blood during the early incubation period, and from liver, lymph nodes, kidney, bladder and urine during the eruptive period of infection. the major target organs were skin and liver; specific pathological changes developed in both. appropriate antibody responses, including those to herpesvirus varicellae foll ... | 1975 | 174129 |
| isolation of varicellazoster virus from blood. | | 1976 | 175145 |
| herpes zoster--a parasitic fossil. | | 1976 | 175355 |
| in vitro susceptibility of varicella zoster virus to adenine arabinoside and hypoxanthine arabinoside. | the in vitro susceptibility of varicella zoster (vz) isolates to adenine arabinoside (ara-a) and hypoxanthine arabinoside (ara-hx) was determined in human skin fibroblasts. using a system in which deamination was inhibited, and using a modified plaque reduction method, the antiviral activities of ara-a and ara-hx were separated. the plaque inhibitory concentration of ara-a for all vz isolates tested was 1 to 2 mug/ml and 80 to 100 mug/ml for ara-hx. a comparison of antiviral activity based upon ... | 1976 | 176937 |
| indirect haemagglutination reaction (lh)-the method of choice for the detection of anamnestic antibodies to varicella - zoster (vz) virus. | the method of indirect haemagglutination is a sensitive quantitative serological reaction for the detection of anamnestic titres of vz antibodies. the curve obtained by the examination of a representative population sample has shown that the occurrence of vz antibodies increases with the age so that 60% of children of under-school age and 90% of 15-year-old children have antibodies to varicella-zoster virus. in adult age groups, seropositivity ranges between 90--100%. the incidence and level of ... | 1976 | 177705 |
| commentary: protection against varicella. | | 1977 | 190580 |
| protection against varicella in family contacts by immediate inoculation with live varicella vaccine. | a live varicella vaccine (oka strain) was given to susceptible household contacts of varicella to test the protective efficacy of the vaccination. twenty-six contacts of 21 families were vaccinated, usually within three days after onset of the index cases. none of the vaccinated children developed clinical symptoms of varicella. eighteen of 24 sera obtained before vaccination were found to be seronegative by complement fixation and neutralization tests. seroconversion was observed in all of the ... | 1977 | 190583 |
| coxsackievirus and adenovirus infection. association with acute febrile and juvenile rheumatoid arthritis. | the prearthritic manifestations of juvenile rheumatoid arthritis in a 16-year-old boy were associated with a rise in coxsackievirus b3 and a9 neutralizing antibody titers from 1:16 to larger than or equal to 1:512, and 1:64 to 1:512, respectively. recurrent polyarthritis followed and has persisted for three years. adenovirus 7 was isolated from the pericardial fluid of a 9-year-old girl in whom juvenile rheumatoid arthritis then developed. of 11 patients with acute, nonspecific, febrile arthriti ... | 1976 | 177792 |
| detection of antibody to varicella-zoster virus by immune adherence hemagglutination. | a serologic test for measurement of antibody to v-z virus by immune adherence hemagglutination is described. initial evaluation of the test has shown it to be highly sensitive, specific, rapid, and simple to perform. the v-z antigen may be stored at -70 degrees, and the test could be performed in any routine serology laboratory. | 1976 | 177988 |
| early diagnosis of virus-caused vesicular rashes by immunofluorescence on skin biopsies. i. varicella, zoster and herpes simplex. | the use of immunofluorescence (if) for the rapid identification of varicella-zoster (v-z) and herpes simplex (hs) antigen in frozen sections of biopsies of early non-vesicular skin lesions was investigated. direct if, using fluorescein- isothiocyanate- conjugated immuoglobulin (fitc ig) of paired human anti-v-z sera and fitc-conjugated negative and positive anti-v-z-monkey ig, yielded specific fluorescence of virus antigen in all 14 varicella cases investigated and in 10/11 zoster cases. in cont ... | 1976 | 178050 |
| varicella-zoster virus and facial palsy. | two cases of ramsey-hunt syndrome are reported, one of which presented features of the guillain-barré syndrome. it is suggested that the varicella-zoster virus is an aetiological factor in the guillain-barré syndrome. | 1976 | 178811 |
| induction of deoxypyrimidine kinase activity in human embryonic lung cells infected with varicella-zoster virus. | deoxypyrimidine kinase (deoxythymidine [tdr] kinase and deoxycytidine kinase) activity was induced in human embryonic lung cells after infection with varicella-zoster virus (vz virus). increased enzyme activity was also produced by using cell-associated virus as inoculum instead of cell-free virus. anti-vz virus serum inhibited both the appearance of cytopathic effect and the induction of enzyme activity. the induced tdr kinase activity was more thermostable than that induced by herpes simplex v ... | 1977 | 191646 |
| peripheral facial palsy and herpes zoster infection. | a clinical and virological study of 133 consecutive cases of peripheral facial palsy has provided evidence for simultaneous infection with the varicella-zoster virus in 9 patients (6-8 per cent). seven of these presented differing but typical manifestations of the ramsay hunt syndrome, and the diagnosis was therefore strongly suspected on the basis of the clinical findings alone. the remaining two patients had neither herpetiform rash nor involvement of the eighth cranial nerve, and had been dia ... | 1976 | 178812 |
| letter: rapid diagnosis of virus infections. | | 1975 | 49678 |
| acute facial palsy. some clinical and virological observations. | a prospective clinical and virological study on 44 patients with acute, peripheral facial paralysis was carried out in consecutive cases during one year. in 9 cases varicella-zoster infections were serologically established. in 5 additional patients an associated varicella-zoster, or herpes simplex, infection was possible. of the 9 confirmed cases, 6 were clinically diagnosed as zoster oticus, whereas on clinical grounds, 3 were regarded as bell's palsy. no evidence was obtained of associated en ... | 1976 | 179268 |
| varicella-zoster antibodies in adult patient with haemoblastoses. | indirect haemagglutination (ih) antibodies to varicella-zoster (vz) virus were investigated, under the identical conditions of a single experiment, in a group of patients with haemoblastoses and 80 normal adults of equal age groups. statistical significance of the differences in vz antibody geometric mean titres between the individual haemoblastoses and normal controls was examined by means of variance analysis. a significantly raised mean titre was still found in the hodgkin's disease group. | 1976 | 180728 |
| necrotizing retinopathy with herpes zoster ophthalmicus: a light and electron microscopical study. | a necrotizing retinopathy following a vesicular cutaneous eruption in the distribution of the right trigeminal nerve developed in a patient who had been receiving systemic corticosteroid therapy one week prior to the onset of herpes zoster ophthalmicus. seven weeks after the herpetic symptoms began, the patient died of pneumonia following an intracerebral hematoma. at postmortem examination, unexpected multiple focal and confluent lesions, which corresponded to areas of extensive retinal necrosi ... | 1976 | 180930 |
| cell-mediated immunity to varicella-zoster virus demonstrated by viral inactivation with human leukocytes. | cell-mediated immunity to varicella-zoster (v-z) virus in persons immune to varicella has been demonstrated, using a tissue culture technique. cell-mediated immunity was reflected by the ability of peripheral leukocytes (lymphocytes and monocytes) from human donors to inactivate v-z virus. leukocytes were stimulated by the addition of noninfectious v-z antigen to cultures newly infected with v-z virus. several days leter, the v-z virus in these cultures was titered. when leukocytes from donors i ... | 1976 | 184040 |
| severe chickenpox and purpura fulminans in zoster treated with vidarabine. | | 1976 | 185190 |
| neuroblastoma, wilms' tumor, and cytomegalovirus. | the possibility that neuroblastomas and wilms' tumors are induced by cytomegalovirus (cmv) was raised and discussed. a large percentage of patients with these tumors have complement-fixing antibodies against cmv. a hypothesis was presented. | 1976 | 185403 |
| enzymatic basis for the selective inhibition of varicella-zoster virus by 5-halogenated analogues of deoxycytidine. | 5-bromodeoxycytidine (brdc) and 5-iododeoxycytidine, at a concentration of 100 mug/ml, effectively inhibit the replication of varicella-zoster (vz) virus in tissue culture. no toxicity could be demonstrated in uninfected cells under the same conditions. studies on the enzymatic basis for this selective inhibition were undertaken. infection of human embryonic lung cell monolayers with vz virus-infected cells results in the induction of thymidine (dt), deoxycytidine (dc), and brdc kinase activitie ... | 1976 | 185427 |
| cellular immunity and herpesvirus infections in cardiac-transplant patients. | we observed severe infection with herpes simplex virus in cardiac-transplant patients despite their high serum antibody levels to this virus. therefore, we sought to correlate clinical susceptibility to two herpesvirus (simplex and zoster) infections with specific cellular immunity, assessed by the transformation and interferon responses of peripheral blood mononuclear cells to heat-inactivated antigens. transformation and interferon response to herps simplex virus was maximally depressed immedi ... | 1977 | 193008 |
| herpesvirus group antibodies in children with hodgkin's disease. | during the period of three years ((1972-1974), serum samples from 60 patients (children and adolescents) with lympho-hematopoietic system diseases were examined for antibodies to all four human herpesviruses. among these were 26 active hodgkin's disease (ahd) patients and 6 hd patients with a minimum five years' remission. simultaneously matched controls (age, sex) of ahd patients were examined. antibody levels against the viral capsid antigen of epstein-barr virus (ebv/vca) in ahd patients were ... | 1977 | 193463 |