| a review of feline viral rhinotracheitis (feline herpesvirus i infection). | | 1979 | 41670 |
| immunogenic and protective effects of the f-2 strain of feline viral rhinotracheitis virus. | the f-2 strain of feline viral rhinotracheitis (fve) virus was administered by intramuscular (im) injection to susceptible cats. the cats developed serum-neutralizing antibodies and were protected to a significant degree when given, by intranasal (in) instillation challenge inoculum of a virulent strain of fvr virus. | 1975 | 163604 |
| evaluation of 6-azauridine and 5-iododeoxyuridine in the treatment of experimental viral infections. | the potential antiviral activity of 6-azauridine and 5-iododeoxyuridine was evaluated in a coordinated study at five institutions. experimental models in five species, the mouse, rabbit, swine, cat, and ferret, were established with use of 10 viruses: herpesvirus hominis types 1 and 2, murine cytomegalovirus, vaccinia virus, shope fibroma virus, transmissible gastroenteritis virus, swine influenza virus, feline viral rhinotracheitis virus, feline panleukopenia virus, and ferret distemper virus. ... | 1976 | 180189 |
| experimental induction of feline viral rhinotracheitis virus re-excretion in fvr-recovered cats. | the re-excretion of feline viral rhinotracheitis (fvr) virus (feline herpesvirus i) by fvr-recovered cats is recorded both spontaneously and following a variety of stimuli, namely, corticosteroid administration, change of housing, and parturition and lactation. at least 27 of 33 (82%) fvr-recovered cats studied were shown to be viral carriers. the carrier state was characterised by periods of viral latency interspersed with episodes of viral shedding. administration of 0-75 mg dexamethasone trim ... | 1977 | 191978 |
| sero-diagnostic aspects of feline herpesvirus infection. | | 1977 | 194079 |
| in vitro antiviral efficacy of ribavirin against feline calicivirus, feline viral rhinotracheitis virus, and canine parainfluenza virus. | ribavirin had marked in vitro activity against feline calcivirus, strain 255, and canine parainfluenza virus, but showed only slight antiviral effect on feline viral rhinotracheitis virus. antiviral activity was manifested by partial to complete suppression of viral cytopathic effect and of viral replication, depending on concentration of ribavirin in the culture medium and dosage of viral inoculum. concentrations of ribavirin as small as 3.2 microgram/ml and 1.0 microgram/ml showed some activit ... | 1978 | 204229 |
| the dose response of cats to experimental infection with feline viral rhinotracheitis virus. | | 1979 | 222816 |
| in vitro interaction of alveolar macrophages and pneumocytes with feline respiratory viruses. | feline alveolar macrophages and feline pneumocytes were inoculated in vitro with low multiplicities of either feline calicivirus or feline viral rhinotracheitis virus. pneumocytes were permissive for both viruses. high titers were attained, and characteristic cytopathic effects developed. alveolar macrophages were permissive for feline viral rhinotracheitis virus, although the cycle of replication was delayed. infection of macrophages with feline calicivirus resulted in the production of viral a ... | 1978 | 352961 |
| studies on cytopathogenic viruses from cats with respiratory infections. iv. properties of hemagglutinin in feline herpesvirus suspensions and receptors on feline erythrocytes. | | 1977 | 916471 |
| replication of feline herpesvirus and feline calicivirus in cell and organ cultures. | virus titers from feline herpesvirus-infected feline tracheal organ cultures were higher than those from feline kidney cell cultures. the time for the development of peak viral yields was longer in organ culture as compared to cell cultures. feline tracheal organ cultures infected with feline calicivirus produced minimal viral titers. | 1976 | 937794 |
| glycoprotein-specific immune response in canine herpesvirus infection. | sera from dogs which were infected with canine herpesvirus (chv) were analyzed for their serological reactivities against virus-specific glycoproteins (gps). by sequential immunoblot analysis using sera from experimentally infected dogs, it was found that the antibody response to gp 145/112 appeared first followed by responses to gp47 and gp80. in addition, all sera from naturally infected dogs which showed neutralizing activity to chv reacted with gp 145/112, whereas 77% and 70% reacted with gp ... | 1992 | 1309997 |
| isolation of feline herpesvirus 1 from the trigeminal ganglia of acutely and chronically infected cats. | | 1992 | 1316965 |
| in vitro responses of cheetah mononuclear cells to feline herpesvirus-1 and cryptococcus neoformans. | in vitro t cell function by domestic cats and cheetahs to two common pathogens, feline herpesvirus-1 (fhv-1) and cryptococcus neoformans, was assessed. peripheral blood mononuclear cells (pbm) were stimulated with two strains of uv-inactivated fhv-1, whole heat-killed organisms or capsular antigen of cryptococcus neoformans, and proliferative responses measured. as a group, cheetah pbm responded significantly poorer than domestic cat pbm when cultured with fhv-1. however, individual cheetah resp ... | 1992 | 1317618 |
| the use of feline herpesvirus and baculovirus as vaccine vectors for the gag and env genes of feline leukaemia virus. | the env and gag genes from feline leukaemia virus were expressed in a thymidine kinase-negative feline herpes-virus and a baculovirus. cats were vaccinated with various combinations of these recombinant viruses and 100% protection against feline leukaemia virus challenge was achieved using an immunization schedule which utilized both env and gag products delivered at both a mucosal and systemic site. | 1992 | 1321214 |
| sequences within the feline immunodeficiency virus long terminal repeat that regulate gene expression and respond to activation by feline herpesvirus type 1. | we constructed a series of deletion mutants of feline immunodeficiency virus (fiv) long terminal repeat (ltr) to identify the regions that regulate gene expression and are responsive to trans-activation of fiv ltr by feline herpes-virus type 1 (fhv-1). we demonstrated that sequences between -124 and -79, and between -21 and -32 (relative to the cap site) are essential for gene expression of fiv in felis catus whole fetus 4 (fcwf-4) cells. further, we demonstrated that the sequence between -63 an ... | 1992 | 1326814 |
| identification and nucleotide sequence of a gene in feline herpesvirus type 1 homologous to the herpes simplex virus gene encoding the glycoprotein b. | the nucleotide sequence of the glycoprotein b (gb) homologous gene of feline herpesvirus type 1 (fhv-1) was determined. the gene was found to be located within a 9.6 kbp sali fragment by southern-blot hybridization with a probe derived from the herpes simplex virus type 1 (hsv-1) gb dna sequence. furthermore, the predominant portion of the coding sequences was mapped to a 1.9 kbp hin cii-ecori and its flanking 2.7 kbp eco ri-eco ri subfragments in the 9.6 kbp sali fragment. the entire nucleotide ... | 1992 | 1333759 |
| herpesvirus infections in seals: a summary of present knowledge. | this review summarises the occurrence of herpesvirus infections in pinnipeds and data from investigations carried out by the authors. these data demonstrate that herpesvirus isolates collected from harbour seals (phoca vitulina linnaeus, 1758) during the 1988 seal epidemic were almost indistinguishable from feline herpesvirus 1 and that antarctic weddell's seals (leptonychotes weddelli lesson, 1826) carry antibodies against seal herpesvirus from the north-western europe seal epidemic. the signif ... | 1992 | 1339068 |
| heterogeneity of feline herpesvirus type 1 strains. | heterogeneity of 9 feline herpesvirus type 1 (fhv-1) strains consisting of the prototype c27 strain, one french isolate, six japanese isolates, and the attenuated vaccine f2 strain was examined by biological, immunological, and molecular biological methods. no significant difference was observed in virus growth and antigenic properties among the strains in crandell feline kidney cell cultures. hemagglutination activity was also detected in all extracts of cells infected with each strain. however ... | 1992 | 1355960 |
| interaction of acute feline herpesvirus-1 and chronic feline immunodeficiency virus infections in experimentally infected specific pathogen free cats. | cats with or without chronic feline immunodeficiency virus (fiv) infection were exposed to feline herpesvirus, type 1 (fhv-1). fiv infected cats became sicker than non-fiv infected cats and required more supportive treatment. however, there were no differences in the length of their illness or in the levels and duration of fhv-1 shedding. fhv-1 infection caused a transient neutrophilia at day 7 with a rapid return to preinfection levels. the neutrophilia coincided with a transient lymphopenia th ... | 1992 | 1363011 |
| immunologic responses in healthy random-source cats fed n,n-dimethylglycine-supplemented diets. | the immunomodulatory capacities of n,n-dimethylglycine (dmg) were examined in random-source cats. blood mononuclear leukocytes of healthy adult cats that had negative results to tests for felv and feline immunodeficiency virus were exposed in vitro to various concentrations of dmg (10 to 1,000 micrograms/ml) and were evaluated for proliferative responses to t- or b-cell phytomitogens. although increased, mean lymphocyte blastogenic responses to phytolectins in dmg-treated cultures did not differ ... | 1992 | 1381880 |
| [the effectiveness of paramunization for the control of feline coryza]. | 20 cats in a cat home were treated prophylactically and therapeutically with baypamun hk. the animals were allocated into three groups as described. 7 freshly admitted clinically healthy cats were treated prophylactically on day 1, 2 and 9 with 1 ml baypamun hk (group i). 7 cats, who already were allocated for one year in the home and were sick of the feline respiratory disease complex were treated as described for group i (group ii). 6 further cats, who also showed symptoms of the feline respir ... | 1992 | 1524577 |
| antarctic seals carry antibodies against seal herpesvirus. | weddell seals in the antarctica had high neutralizing antibody titres to seal- and feline herpesvirus and none against phocine distemper virus. crab-eater seals were free of antibodies. this suggests an evolutionary wide spread of seal herpesvirus. | 1992 | 1562238 |
| activation of feline immunodeficiency virus long terminal repeat by feline herpesvirus type 1. | by transfection of a recombinant plasmid containing the feline immunodeficiency virus (fiv) long terminal repeat (ltr) linked to the chloramphenicol acetyltransferase (cat) gene followed by infection of feline herpesvirus type 1 (fhv-1) into crandell feline kidney cells and felis catus whole fetus 4 cells, enhancement of cat activity was demonstrated. furthermore, individual feline t-lymphocytes were productively co-infected with both fiv and fhv-1 in vitro as determined by two-color immunofluor ... | 1991 | 1651603 |
| replication of feline herpesvirus type 1 in feline t-lymphoblastoid cells. | | 1991 | 1653042 |
| experimental infection of two dogs with a canine isolate of feline herpesvirus type 1. | | 1991 | 1659021 |
| intracellular localization and epitope mapping of feline herpesvirus type 1 glycoproteins. | monoclonal antibodies (moabs) were used to characterize feline herpesvirus type 1 (fhv-1) glycoproteins (gp). intracellular localization and transport of these proteins as revealed by a sequential indirect immunofluorescence assay (ifa) on fixed infected cells showed slight differences between fhv-1 gp143/108 and gp113. antibodies against gp143/108 first showed membrane fluorescence at 4 hrs post-infection (pi) followed by a pronounced perinuclear and cytoplasmic staining from 8 hrs pi onwards. ... | 1990 | 1693409 |
| restriction endonuclease mapping of the genome of feline herpesvirus type 1. | restriction endonuclease mapping was used to determine the molecular structure of feline herpesvirus type 1 (fhv-1) strain b 927. fhv-1 dna purified from infected cells by pulsed field gel electrophoresis was partially restricted with sau 3a to generate a series of overlapping fragments of 10-20 kb. embl 4 dna was digested with bam hi and sal i and viral dna was inserted into the "stuffer" region. recombinant phage were selected on e. coli strain q359. single and double digestions with the enzym ... | 1991 | 1825774 |
| homologous and heterologous antibody responses of mice immunized with purified feline herpesvirus type 1 and canine herpesvirus glycoproteins. | the three glycoproteins each of feline herpesvirus type 1 (fhv-1) and canine herpesvirus (chv) were purified by affinity chromatography using glycoprotein-specific monoclonal antibodies and used individually or in combination in immunizing mice to determine their relative immunogenicity. all the glycoproteins induced detectable virus neutralizing antibodies to the homologous virus but fhv-1 gp143/108 and its cross-reacting counterpart, chv gp145/112, elicited the highest titers not only to the h ... | 1991 | 1832031 |
| isolation of feline calicivirus and feline herpesvirus from domestic cats 1980 to 1989. | isolation rates of feline herpesvirus (fhv) and feline calicivirus (fcv) from oropharyngeal swabs, taken from 6866 cats in 1980 to 1989 were studied retrospectively. fcv was isolated from 1364 (19.9 per cent) and fhv from 285 (4.2 per cent). the ratio of fcv:fhv isolations varied from 1.3:1 to 15:1 in individual years with an overall ratio of 4.8:1. isolation of both viruses was fairly uniform for each year and there was no breed or sex disposition to either virus. of 872 cats shedding fcv and 2 ... | 1991 | 1850183 |
| persistent cutaneous ulcers associated with feline herpesvirus type 1 infection in a cheetah. | persistent cutaneous ulcers developed in a female cheetah cub after an episode of rhinotracheitis. when they were 3 weeks old, the cub and a male littermate developed mucopurulent oculonasal discharge consistent with feline herpesvirus type 1 infection (feline viral rhinotracheitis). the male cub was weaned and its lesions resolved. the female cub remained with the dam until the cub was 3 months old, at which time plaque-like lesions developed on the eye margins and muzzle. these plaques regress ... | 1991 | 1851739 |
| quantitative assessment of the germicidal efficacy of ultrasonic energy. | propagated (free-field) ultrasonic energy at a frequency of 26 khz was used to expose aqueous suspensions of bacteria (escherichia coli, staphylococcus aureus, bacillus subtilis, and pseudomonas aeruginosa), fungus (trichophyton mentagrophytes), and viruses (feline herpesvirus type 1 and feline calicivirus) to evaluate the germicidal efficacy of ultrasound. there was a significant effect of time for all four bacteria, with percent killed increasing with increased duration of exposure, and a sign ... | 1991 | 1892396 |
| cholinergic reactivity of tracheal smooth muscle after infection with feline herpesvirus i. | airway responsiveness was studied in cats 3 or 6 days after exposure to feline herpesvirus i. control cats were sham inoculated with tissue culture media. intrathoracic airway caliber was evaluated by pulmonary resistance (rl) and dynamic compliance (cdyn). trachealis shortening was quantitated with microfoil strain gauges, which measured the external diameter of tracheal ring 4. airway smooth muscle contraction was produced using vagal stimulation and local infusion of acetylcholine. the diamet ... | 1990 | 1963887 |
| serological survey of the iriomote cat (felis iriomotensis) in japan. | the iriomote cat (felis iriomotensis) was first discovered on iriomote island in the yaeyama islands of japan in 1965. ten male and 11 female adult cats were captured during the 6 yr period from 1983 to 1988. these were examined for evidence of viral and mycoplasmal infections. neither mycoplasma sp. nor ureaplasma sp. were detected in swab samples of oropharyngeal and urogenital regions. a foamy virus was isolated from the oropharyngeal swab of a female cat examined in 1988. feline leukemia vir ... | 1990 | 2110982 |
| the biology of bovine herpesvirus-4 infection of cattle. | the biology of bovine herpesvirus-4 (bhv-4) infection of cattle is reviewed. the infection is distributed worldwide. most of isolated viruses are non-pathogenic in cattle; some of them are able to produce a genital disease. twenty-nine structural polypeptides were described; ten of them are glycosylated. two major glycoproteins were characterized by monoclonal antibodies. restriction maps of bhv-4 dna are available for the enzymes ecori, bamhi and hindiii. the strain variations studied by restri ... | 1990 | 2155770 |
| immunological relationship between feline herpesvirus type 1 (fhv-1) and canine herpesvirus (chv) as revealed by polyvalent and monoclonal antibodies. | polyvalent and monoclonal antibodies were used to demonstrate serological and antigenic relationships between feline herpesvirus type 1 (fhv-1) and canine herpesvirus (chv). using virus neutralization tests, enzyme-linked immunosorbent and indirect immunofluorescence assays, and immunoblotting analysis, reciprocal cross-reactivities to the heterologous virus were observed with some polyvalent and monoclonal antibodies. one monoclonal antibody against chv neutralized fhv-1 infectivity and one mon ... | 1990 | 2162158 |
| feline herpesvirus ocular disease. | infection by fhv-1 is one of the most common ophthalmic diseases of domestic cats worldwide. although the usual manifestations are conjunctivitis and keratitis, infection with this virus has been linked to a variety of other ophthalmic syndromes of cats, including keratoconjunctivitis sicca and corneal sequestration. ocular fhv-1 infection of cats provides a significant diagnostic challenge to the practicing veterinarian because, in chronic cases, antigen detection tests often yield negative res ... | 1990 | 2163558 |
| homology between feline herpesvirus-1 and canine herpesvirus. | the purpose of this study was to determine the extent of the relatedness between feline herpesvirus-1 (fhv-1) and canine herpesvirus (chv). immunoprecipitation studies using antisera to fhv-1 and chv revealed that both share virion glycoprotein antigens with apparent molecular weights of approximately 60 and 68 kda. two non-glycosylated, virion-associated antigens of each virus also displayed weaker cross reactivity. southern blot hybridization experiments indicated that restriction fragments wh ... | 1990 | 2174232 |
| restriction endonuclease analysis of dna from isolates of feline herpesvirus type 1. | dnas prepared from whole feline embryo cells infected with a standard laboratory strain of fhv-1, b927, and 50 wild type isolates were digested with a variety of restriction endonucleases. the resulting fragments were separated on agarose gels and southern blotting performed. to visualize the fragments, b927 dna was purified by pulsed field gel electrophoresis, labelled with alpha 32p and used as a hybridization probe. with most enzymes a large number of the isolates displayed altered mobilities ... | 1990 | 2280485 |
| a case report: encephalitis in lions. pathological and virological findings. | an acute outbreak of encephalomyelitis in lions from a safari-park was investigated. three moribund lions were euthanatized and a post mortem examination was performed. a disseminated non-suppurative polioencephalomyelitis with demyelination in the spinal cord was the only pathological finding. from tonsil material of one lion feline herpesvirus type 1 was isolated. canine distemper virus, pseudorabies virus, feline infectious peritonitis virus and rabies were excluded as cause of the disease. t ... | 1990 | 2311536 |
| feline herpesvirus type 1 glycoproteins eliciting virus neutralizing and hemagglutination-inhibiting antibodies. | monoclonal antibodies (moabs) to feline herpesvirus type 1 (fhv-1) were produced to identify the virus-specified immunogenic proteins. when antigens recognized by the moabs were investigated by immunoblot and immunoprecipitation assays using fhv-1-infected cell lysate, four groups of immunogenic proteins were identified. moabs directed against 60 kda, 113 kda, and 143 kda/108 kda glycoproteins had virus neutralizing activities, but those against 170 kda protein did not. furthermore, moabs to the ... | 1990 | 2327898 |
| susceptibility of feline herpesvirus 1 and a feline calicivirus to feline interferon and recombinant human leukocyte interferons. | feline lung monolayer cultures were treated with either a feline interferon (ifn) or one of two recombinant human alpha-ifns and then challenged with feline herpesvirus 1 (fhv-1), feline calicivirus (f-9 strain), or vesicular stomatitis virus. treatment with these ifns reduced the viral yield for each of these three viruses as compared with that of control cultures. vesicular stomatitis virus was more sensitive to each ifn than were fhv-1 or feline calicivirus f-9. | 1985 | 2418778 |
| experimental ocular herpesvirus infection in the cat. sites of virus replication, clinical features and effects of corticosteroid administration. | experimentally induced ocular feline herpesvirus 1 (fhv-1) infection was studied in 30 specific pathogen-free cats. in ten cats, the ability of five field isolates of fhv-1 to replicate in the epithelium and substantia propria of cornea and conjunctiva was demonstrated by histochemical techniques. feline herpesvirus 1 was found to preferentially infect and induce necrosis of conjunctival epithelium. although significant histologic lesions were not induced, all fhv-1 strains were observed to repl ... | 1989 | 2474518 |
| in vitro susceptibility of feline herpesvirus-1 to vidarabine, idoxuridine, trifluridine, acyclovir, or bromovinyldeoxyuridine. | in vitro activities of 9-[( 2-hydroxyethoxy] methyl) guanine (acyclovir), (e)-5-(2-bromovinyl)-2'deoxyuridine, 9-beta-d-arabinofuranosyladenine (vidarabine), 5-iodo-2'-deoxyuridine (idoxuridine), and 5-trifluoromethyl-2'-deoxyuridine (trifluridine) were studied against 6 strains of feline herpesvirus-1. a significant difference was not detected among viral strains in their susceptibility to these compounds (p = 0.442). the relative potency of these compounds was trifluridine much greater than id ... | 1989 | 2493210 |
| synergistic antiviral activities of acyclovir and recombinant human leukocyte (alpha) interferon on feline herpesvirus replication. | the antiviral activities of 9-(2-hydroxyethoxymethyl)guanine (acyclovir; acv) either alone or combined with recombinant human leukocyte (alpha) a/d interferon (rhuifn-alpha) against feline herpesvirus type 1 (fhv-1) were evaluated in feline embryo cell cultures, using an infectivity-inhibition assay. in acv-treated cultures, the 50% inhibitory dose (id50) was approximately 10 to 20 micrograms of acv/ml. maximal inhibition of fhv-1 infectivity (range, 3.4 to 4.2 log10 tcid50) was observed when hi ... | 1989 | 2552872 |
| enhancement of neutralizing activity of anti-feline herpesvirus type 1 sera by complement supplementation. | | 1989 | 2558248 |
| identification of the thymidine kinase gene of feline herpesvirus: use of degenerate oligonucleotides in the polymerase chain reaction to isolate herpesvirus gene homologs. | feline herpesvirus 1 (fhv) is the causative agent of viral rhinotracheitis in cats. current vaccination programs employing attenuated live and killed fhv vaccines have been effective in reducing the incidence of this disease. as an initial step in the development of recombinant fhvs for use in the vaccination of cats, we have identified the thymidine kinase (tk) gene of this feline-specific alphaherpesvirus. comparisons of the amino acid sequences of other herpesvirus tk proteins have shown that ... | 1989 | 2746729 |
| identification of feline herpesvirus type 1-hemagglutinin. | the crude hemagglutinin of feline herpesvirus type 1 (fhv-1), solubilized from infected fcwf-4 cells by detergents, was partially purified by three kinds of chromatographic methods. lectin-affinity chromatography showed the hemagglutination (ha) activity in fractions, which was bound to concanavalin a-sepharose and then eluted by alpha-methyl d-mannoside, suggesting that the hemagglutinin might include a glycoprotein. ion-exchange and gel-exclusion chromatographies were also capable of purifying ... | 1989 | 2761153 |
| antibody and cell-mediated immune responses to feline herpesvirus 1 following inactivated vaccine and challenge. | | 1987 | 2829473 |
| glycoprotein-specific immune responses in cats after exposure to feline herpesvirus-1. | to obtain synchronous infection, 10 cats were inoculated with feline herpesvirus-1 (fhv-1) on the oral, nasal, and conjunctival mucosa. swab specimens of the nasal, conjunctival, and pharyngeal mucosa were obtained for virus isolation from each cat before inoculation and at 3-day intervals thereafter until postinoculation day 21. recovery of virus and evidence of clinical signs were used to document fhv-1 infection. serum was obtained from blood samples collected sequentially from each cat betwe ... | 1988 | 2847603 |
| further biological, serological and biochemical characterization of north american, european and southeast asian strains of bovine herpesvirus 1 compared with other alphaherpesvirinae members. | hemagglutination activity, structural protein profiles and neutralization assays were used in a comparative study of bovine herpesvirus 1 strains from the u.s.a., canada, great britain, denmark and malaysia with equine, feline and human herpesviruses in order to further characterize the bovine herpesvirus 1 hemagglutinin. bovine herpesvirus 1 strains of different geographical origins all showed hemagglutinating activity for mouse erythrocytes; furthermore, feline herpesvirus 1 was also shown to ... | 1988 | 2852870 |
| comparison of a cheetah herpesvirus isolate to feline herpesvirus type 1. | a cytopathogenic virus with size and structural characteristics of a herpesviridae was isolated from a cheetah with severe ulcerative dermatitis. restriction endonuclease analysis and cross-hybridization studies revealed that the isolate was related to feline herpesvirus type 1 (fhv-1). antigenic comparison studies using anti-fhv-1 serum demonstrated the presence of common antigens in the fhv-1 and the isolate from the cheetah. | 1988 | 2898931 |
| an improved method for hemagglutinin extraction from feline herpesvirus type 1-infected cell line. | hemagglutination (ha) activity of feline herpesvirus type 1 (fhv-1) propagated in feline lung cell culture and two established feline cell lines, crfk and fcwf-4, was investigated. intra- and extracellular crude samples obtained from those infected cell cultures did not show ha activity. however, when treated with tween 80-ether, ha activity appeared. there was no correlation between virus infectivity titers and the ha titers at various harvesting times, and besides, hemagglutinins were found in ... | 1989 | 2927025 |
| serologic and virologic surveys on feline herpesvirus and feline calicivirus infections in cats for experimental use. | serologic survey and virus isolation of feline herpesvirus (fhv) and feline calicivirus (fcv) were performed on cats used for research at the laboratory animal research centre, the university of tsukuba, over the period from 1978 to 1981. of the 507 mature and immature cats, 4 months old or older, 102 (20.1%) had hi antibody against fhv and 412 (81.3%) sn antibody against fcv. some 23 (16.2%) and 76 (53.5%) kittens among 142 younger than 4 months had antibodies against fhv and fcv, respectively. ... | 1985 | 2998829 |
| evaluation of tri-combinant vaccine for feline herpesvirus, calicivirus and panleukopenia virus infections in japanese native cats. | tri-combinant vaccine consisting of attenuated feline herpesvirus (fhv) and feline calicivirus (fcv) and inactivated feline panleukopenia virus (fplv), were evaluated for safety and efficacy, using japanese native cats and the viral strains isolated in japan. thirty-eight 9- to 12-week-old kittens were inoculated intramuscularly and subcutaneously with the vaccine. consequently, no adverse reaction was found, and protective efficacy was confirmed by challenge tests with the virulent strains of e ... | 1985 | 2998830 |
| biochemical and antigenic characterization of feline herpesvirus-1-like isolates from dogs. | the dna and polypeptide patterns of feline herpesvirus-1 (fhv-1), a virus usually associated with feline respiratory infections, were compared to those of five herpesvirus isolates from dogs. these canine isolates had been shown to be antigenically similar to fhv-1 by cross neutralization tests. dna from fhv-1 (c-27 strain) and each canine isolate was digested with either bam hi, eco r 1 or sal i and analyzed on 0.8 per cent agarose gels. the restriction digest patterns of the canine isolates we ... | 1986 | 3013133 |
| physical characterization of the genome of feline herpesvirus-1. | the physical structure of the genome of feline herpesvirus-1, a major upper respiratory tract pathogen of cats, was studied. purified fhv-1 dna was analyzed by restriction endonuclease and gamma 5' exonuclease digestion, blot hybridization, and electron microscopy. to facilitate further studies, nine bacteriophage clones were isolated which contained 85% of the viral genome as sali inserts, and dna from these clones was used in blot hybridization experiments and as substrates for restriction dig ... | 1986 | 3019000 |
| responses of cats to nasal vaccination with a live, modified feline herpesvirus type 1. | intranasal vaccination with a cold-adapted strain of feline herpesvirus type 1 (fhv-1) two days before challenge gave partial protection, and four days before challenge gave complete protection, against feline viral rhinotracheitis. protection at this time appeared to be specific since vaccination with fhv-1 did not affect the disease caused by the unrelated feline calicivirus. the time course of onset of protection also confirmed that the protective mechanism was likely to be specific. however, ... | 1986 | 3027798 |
| clinical and immunological responses of cats to feline herpesvirus type 1 infection. | cats which were challenged with feline herpesvirus type 1 developed clinical signs typical of feline viral rhinotracheitis whether or not they had been vaccinated against the disease. however, the clinical disease was less severe and of shorter duration in the vaccinated cats. after challenge, feline herpesvirus type 1 was recovered from the nostrils, oropharynx and peripheral blood leucocytes. leucocytosis, primarily a neutrophilia, occurred initially in all the cats and was followed after clin ... | 1987 | 3035778 |
| antibody and complement mediated lysis of felid herpesvirus 1 infected cells in vitro. | the lysis of cells infected by felid herpesvirus 1 (fhv) by feline anti-fhv antibody and complement was demonstrated. lytic activity was sensitive to dilution of both antibody and, especially, complement. it was first detected within 10 to 20 minutes, increased rapidly during the next 30 minutes of incubation and then rose more slowly in a linear manner. using standard antibody and complement concentrations and assay duration, it was shown that fhv infected cells underwent significant (p less th ... | 1987 | 3039620 |
| antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl)guanine (brl 39123) in cell culture. | the activity of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (brl 39123) against several herpesviruses was compared with that of acyclovir (acv). in plaque reduction tests with clinical isolates of herpes simplex virus type 1 (hsv-1), herpes simplex virus type 2 (hsv-2), and varicella-zoster virus, mean 50% inhibitory concentrations (ic50s) (n = number tested) for brl 39123 were 0.4 (n = 17), 1.5 (n = 13), and 3.1 (n = 5) micrograms/ml, respectively. corresponding ic50s for acv were 0.2, 0.6, an ... | 1987 | 3631945 |
| variable sensitivity of a feline embryo cell line and of three kitten kidney cell cultures to feline herpes- and caliciviruses. | the number of plaques produced in a feline embryo (femb) cell line and in three independently derived kitten kidney (kk) cell cultures varied in a consistent and reproducible manner when each was inoculated with the same number of feline herpesvirus 1 (fhv1) plaque forming units (pfu); the three kk cells produced 2-9 times more plaques than femb cells. one of the three kk cells produced fhv1 plaques that were smaller in diameter than those femb cells. each of the three kk cell cultures inoculate ... | 1986 | 3705445 |
| feline herpesvirus infection in fused cultures of naturally resistant human cells. | feline herpesvirus (fhv) attaches to, but does not penetrate, naturally resistant human embryonic lung cells. when the cells with attached virus are subsequently fused with inactivated sendai virus, fhv causes characteristic cytopathic effects, but no infectious virus can be recovered from the infected cells. | 1969 | 4306719 |
| feline viruses. vii. immunity to the feline herpesvirus in kittens inoculated experimentally by the aerosol method. | | 1970 | 4315098 |
| morphological changes in productive and abortive infection by feline herpesvirus. | feline herpesvirus produces characteristic morphological alterations in feline kidney cells. nucleocapsid particles are formed in infected nuclei and are enveloped as they pass through the modified inner nuclear membrane. aggregates of dense granular material and filamentous structures also regularly appear in infected nuclei. infection of human embryonic lung cells by feline herpesvirus results in the appearance of intranuclear inclusion bodies, aggregates of dense granular material, and bundle ... | 1970 | 4315960 |
| virologic and immunologic aspects of feline viral rhinotracheitis virus. | | 1971 | 4325039 |
| pathogenicity of feline viral rhinotracheitis virus and effect on germfree cats, growing bone, and the gravid uterus. | | 1971 | 4325041 |
| feline herpesvirus associated with interstitial pneumonia in a kitten. | | 1971 | 4328223 |
| experimental feline herpesvirus infection in the pregnant cat. | intravenous inoculation of pregnant cats with feline herpesvirus produced minimal illness but resulted in abortion, intrauterine fetal death and congenital fetal infection. placental lesions included multiple infarcts in the placental labyrinth, thrombosis of maternal vessels in the endometrium and placenta, and multifocal necrosis of the giant-cell trophoblast and endometrial epithelium in the junctional zone of the placenta associated with eosinophilic intranuclear inclusion bodies. the virus ... | 1971 | 4328861 |
| ocular manifestations of feline herpesvirus infection. | | 1971 | 4330456 |
| bone lesions produced by feline herpesvirus. | | 1971 | 4332859 |
| virus-induced cholesterol crystals. | one of the crystal types induced in cell cultures by a new feline herpesvirus was identified as cholesterol by crystal structure, polarized light microscopy, and mass spectroscopy. | 1973 | 4352777 |
| identification and characterization of a second feline herpesvirus. | a feline virus isolate previously reported as adenovirus-like has more recently been identified and characterized as a new feline herpesvirus. this herpesvirus, which appears to be cell associated, has some characteristics of the cytomegaloviruses and has been found to induce chemical crystal formations in infected cell cultures. | 1974 | 4593345 |
| re-excretion of feline viral rhinotracheitis virus following corticosteroid treatment. | | 1973 | 4762288 |
| effects of nucleic acid analogues on the multiplication and cytopathogenicity of feline viral rhinotracheitis virus in vitro. | | 1967 | 6069051 |
| [nasal infection of the domestic cat with feline herpesvirus as an animal model of experimental viral labyrinthitis]. | looking for a suitable animal model of experimental labyrinthitis we performed in vivo infections of the domestic cat with feline rhinotracheitis virus. after instillation of the virus suspension into the nose of the anaesthetized cat we could find the complete virus particles in so-called virus factories in the nasal mucosa four days later by means of electron-microscopy. the adjacent ganglia of the olfactory nerve were stained by immunohistochemical methods and showed positive viral antigen. a ... | 1984 | 6090824 |
| virucidal disinfectants and feline viruses. | thirty-five commonly used commercial disinfectants (disinfectants, antiseptics, sanitizers, and detergents) were evaluated for their virucidal activity against three feline viruses; feline viral rhinotracheitis virus (a herpesvirus), feline calicivirus, and feline panleukopenia virus (a parvovirus). disinfectants were diluted as recommended by the manufacturer and were reacted with virus for 10 minutes at room temperature. viruses were separated from disinfectants by gel filtration in special ce ... | 1980 | 6245610 |
| isolation of feline herpesvirus 1 from a young kitten. | five kittens exposed neonatally to older cats exhibiting fever with nasal and ocular discharge became ill and died within 10 days of the onset of illness. one kitten which died at 16 days old was examined post mortem and feline herpesvirus 1 was isolated from the brain, liver, lung and spleen. | 1980 | 6255661 |
| feline respiratory tract disease in louisiana. | an investigation of feline respiratory tract disease (frd) was made involving 65 affected cats (group 1) and 65 control cats (group 2) matched for age, sex, and residence. feline calicivirus strains (fcv), feline herpesvirus-1 (fhv-1), or both, were isolated from 59% of group 1 cats and from 7% of group 2 cats. isolation of these viruses showed a significantly greater (p < 0.05) relative risk for group 1 cats. virus isolations were three times more frequent from males than from females older tha ... | 1980 | 6255833 |
| feline respiratory virus carriers in clinically healthy cats. | in two surveys, feline calicivirus was cultured from 19.7% and 15% of 66 and 201 clinically healthy cats respectively. feline viral rhinotracheitis virus was cultured also from 1.5% of oropharyngeal swabs collected in both surveys. feline syncytial virus was isolated from 5.5% oropharyngeal swabs collected in the second survey. the use of serological examination and corticosteroid treatment to stimulate virus shedding demonstrated that 25.8% cats in the first survey were carriers of feline viral ... | 1981 | 6266382 |
| studies on viral respiratory disease in laboratory cats. i. isolation of feline herpesvirus and choice of proper disinfectant. | in the laboratory cat colony consisted of 14 korats and 8 japanese native cats, the disease characterized by upper respiratory signs occurred. seven cytopathogenic agents were isolated from the oropharyngeal swabs and necropsy materials of affected cats by means of inoculation to primary feline kidney cell cultures. one of the isolates (ks-1 strain) was identical with feline herpesvirus (fhv), and appeared to be a causal agent of the trouble. properties of the ks-1 strain were in general agreeme ... | 1982 | 6281040 |
| diarrheal condition in dogs associated with viruses antigenically related to feline herpesvirus. | viruses with properties consistent with herpesvirus were isolated from dogs with diarrhea. the viruses were shown to be antigenically related to feline herpesvirus-1 (fhv-1) by virus neutralization tests. it was also observed that a canine herpesvirus (chv) prototype, d004, and two field isolates from fatal chv infections in 2-week-old and 6-week-old puppies were neutralized at a low level by antiserum to fhv-1. reciprocal neutralization tests with chv antiserum against fhv-1 were negative. thes ... | 1982 | 6286250 |
| feline viral rhinotracheitis virus: explant and cocultivation studies on tissues collected from persistently infected cats. | tissues from 16 feline viral rhinotracheitis (fvr) carrier cats and 15 controls were examined by the techniques of homogenisation, cocultivation and explant cultivation. the tissues examined included trigeminal ganglion and maxillary nerve, olfactory lobe and nerve endings, tonsils, submandibular lymph node, spleen and parotid salivary gland. most of the cats were shedding fvr virus in the oropharynx at the time the tissues were collected. no evidence of a persistent fvr virus infection was foun ... | 1982 | 6296952 |
| sensitivity of equine herpesviruses 1 and 3 in vitro to a new nucleoside analogue, 9-[[2-hydroxy-1-(hydroxymethyl) ethoxy] methyl] guanine. | the following members of the herpetoviridae family were tested to determine their sensitivities to the new antiviral drug, biolf-62: equine herpesvirus types 1 and 3, human herpesvirus types 1 and 2, swine herpesvirus, bovine herpesvirus type 4, feline herpesvirus, canine herpesvirus, and herpes simiae virus. equine herpesviruses 1 and 3, human herpesviruses 1 and 2, and herpes simiae virus were all sensitive to biolf-62 at concentrations of less than 0.55 micrograms/ml. equine herpesvirus types ... | 1983 | 6307092 |
| biochemical study of the feline herpesvirus 1. identification of glycoproteins by affinity. | feline viral rhinotracheitis herpesvirus (feline herpesvirus 1; fhv-1) was purified by rate zonal isopycnic centrifugation. viral nucleocapsids were isolated from the nuclei and purified. analysis of the purified and radiolabelled viral polypeptides and glycoproteins by gradient sds polyacrylamide gel electrophoresis revealed that 23 viral proteins and 6 glycoproteins were present in the whole virus particle. tween 80-diethylether treatment removed the major glycoproteins. fhv-1 viral glycoprote ... | 1984 | 6721681 |
| virucidal efficacy of the newer quaternary ammonium compounds. | the virucidal activity of several disinfectants containing newer generation quaternary ammonium compounds (qacs) as their active ingredients was evaluated. disinfectants were used at the manufacturers' recommended dilutions with isolates of feline herpesvirus, feline calicivirus, and canine parvovirus, and a contact time of 10 minutes at room temperature. detoxification of virus/disinfectant solutions was done by dialysis prior to virus assay in cell cultures. two of four disinfectants completel ... | 1995 | 7634062 |
| [feline calicivirus: a review]. | the contagious coryza is an acute disease in cats, which is caused by feline calicivirus (fcv) and feline herpesvirus type-1 (fhv-1). fcv appears to be isolated more frequently from cats than fhv-1. this review summarizes the current knowledge about fcv and about the clinic, epidemiology, and pathogenesis of the disease induced. particular problems of immunoprophylaxis of infection with fcv are also discussed. | 1995 | 7676440 |
| homogeneous production of feline interferon in silkworm by replacing single amino acid code in signal peptide region in recombinant baculovirus and characterization of the product. | in a previous paper we reported that we constructed a recombinant baculovirus named bmfeifn1 which produced recombinant feline interferon (feifn) in silkworm after infection. high purification of feifn in body fluid from the larvae revealed that two kinds of feifn were produced by the bmfeifn1. the difference between the two in the nh2-terminal amino acid sequence was clarified, and two kinds of processing at different sites in feifn precursor were suggested. changing one residue of the amino ac ... | 1993 | 7685640 |
| restriction endonuclease analysis of field isolates of feline herpesvirus type 1 and identification of heterogeneous regions. | the genomic heterogeneity of 78 isolates of feline herpesvirus type 1 (fhv-1) recently isolated from cats suspected to have feline viral rhinotracheitis was analyzed by examining the digestion patterns found with restriction endonuclease mlui. the fhv-1 field isolates were classified into at least three genotypes, namely, the c7301, f2 (an attenuated vaccine strain), and c7805 types. the c7301 type seems to be a major type, since 64 of the 78 isolates belonged to this type. eight and six isolate ... | 1995 | 7699046 |
| transcriptional analysis of the short segment of the feline herpesvirus type 1 genome and insertional mutagenesis of a unique reading frame. | transcription mapping was performed in the short region of the feline herpesvirus type 1 (fhv-1) genome as a first approach to the functional analysis of open reading frames encoding the homologs of the herpes simplex virus type 1 (hsv-1) gd, gl, ge, us9, and probably also us8.5. all reading frames appeared to be transcribed. transcripts were grouped into two nested rna sets; namely, the coterminal transcripts of gd and gl and the coterminal transcripts of ge, us8.5, and us9. this situation was ... | 1995 | 7747442 |
| comparisons among feline herpesvirus type 1 isolates by immunoblot analysis. | feline herpesvirus type 1 (fhv-1) isolated from cats suspected for feline viral rhinotracheitis could be divided into 3 genotypes (c7301, f2 and c7805 types) by digestion pattern with a restriction enzyme m1ui[16]. variation of immunogenic products of 77 isolates were examined by immunoblot analysis using a polyvalent cat serum against c7301 strain, japanese prototype strain of fhv-1. the result showed that a 36 kda band was detected in 31 out of the 63 isolates belonging to c7301 type. however ... | 1995 | 7756409 |
| an epizootic of feline herpesvirus, type 1 in a large specific pathogen-free cat colony and attempts to eradicate the infection by identification and culling of carriers. | this study describes the clinical course of an inadvertent feline herpesvirus, type 1 (fhv-1) outbreak in 2 specific pathogen-free (spf) research and breeding colonies housing 690 cats and assesses a programme that was designed to eradicate the virus from the colonies. the clinical signs observed in these cats were milder, with more eye involvement than those previously described for fhv-1 infection and did not include abortion. fhv-1 eradication was based on the detection and elimination of bot ... | 1994 | 7830371 |
| effects of incidental infections and immune activation on disease progression in experimentally feline immunodeficiency virus-infected cats. | specific pathogen-free cats were experimentally infected with feline immunodeficiency virus (fiv) and subsequently exposed to common infectious pathogens and immune stimuli over a 3-year period. cats with preexisting fiv infection showed signs of disease after exposure to haemobartonella felis, toxoplasma gondii, feline herpesvirus-1, and feline calicivirus similar to signs in non-fiv-infected cats, although they were more severe. no adverse effects of immunization with inactivated rabies virus ... | 1994 | 7916048 |
| the gene downstream of the gc homologue in feline herpes virus type 1 is involved in the expression of virulence. | feline herpesvirus type 1 (fhv-1) mutants were constructed, carrying a beta-galactosidase marker gene integrated into the region downstream of the gene encoding the homologue of glycoprotein c (gc) of herpes simplex virus type 1. in cell culture, no differences in replication were observed between mutants and the parent fhv-1 strain. however, in experimentally infected cats, mutants caused fewer clinical signs after oronasal administration although they replicated to the same extent as the paren ... | 1994 | 7964620 |
| a gd homologous gene of feline herpesvirus type 1 encodes a hemagglutinin (gp60). | a gene-encoding glycoprotein d (gd) homologue of feline herpesvirus type 1 (fhv-1) was identified and sequenced. it was located within an ecori 4.3-kbp fragment in the middle of the unique short region. the primary translation product of the gd homologous gene is predicted to consist of 374 amino acids with a molecular weight (mw) of 43.2 kda. comparative analysis among gd counterparts of other herpesviruses revealed that six cysteine residues which correlate with disulfide bond structure were c ... | 1994 | 8030205 |
| nucleotide sequence and characterization of the feline herpesvirus type 1 immediate early gene. | we report the nucleotide sequence of feline herpesvirus type 1 (fhv-1) immediate early (ie) gene encoding a homologue to the icp4 protein of herpes simplex virus type 1 and its flanking sequences. when we examined the regulatory function of the fhv-1 ie gene product by using the transient transfection assay with an effector plasmid expressing the fhv-1 ie gene in combination with chimeric various promoter-chloramphenicol acetyltransferase reporter constructs, the product was able to transactivat ... | 1994 | 8091674 |
| identification of the feline herpesvirus type 1 (fhv-1) genes encoding glycoproteins g, d, i and e: expression of fhv-1 glycoprotein d in vaccinia and raccoon poxviruses. | the genome of feline herpesvirus type 1 (fhv-1), the major cause of viral upper respiratory disease in cats, contains several genes encoding homologues of herpes simplex virus type 1 (hsv-1) glycoproteins. restriction mapping studies have indicated that the group d genome of fhv-1 contains a unique short region that is 9.0 kb long. the nucleotide sequence of a 6.2 kb portion of this region was determined. analyses of this sequence have identified five open reading frames capable of encoding homo ... | 1994 | 8207390 |
| immunological characterization of the feline herpesvirus-1 glycoprotein b and analysis of its deduced amino acid sequence. | feline herpesvirus 1 (fhv-1) is an important viral pathogen of cats. like other alphaherpesviruses, fhv-1 contains a hsv-1 glycoprotein b (gb) homolog. in this study, monospecific antisera to hsv-1 gb reacted with three fhv-1 proteins (100, 64, and 58 kda) present in virion lysates by immunoprecipitation and immunoblot analyses. reduced stringency hybridization experiments using a hsv-1 gb probe localized the fhv-1 gb gene to a 9.6-kb sa/l fragment in the unique long region of the genome. northe ... | 1993 | 8212548 |
| clinical and laboratory findings in chronic conjunctivitis in cats: 91 cases (1983-1991). | clinical findings and laboratory test results from 91 cats with chronic conjunctivitis were studied to determine the causes of the disease and the sensitivity of diagnostic procedures used, and to identify correlations between results of various diagnostic procedures and clinical or signalment variations. mean age of affected cats was 2.9 +/- 2.7 years (+/- sd), with a range from 1 month to 11 years. conjunctivitis was more likely to be bilateral (56 cats) than unilateral (35 cats). in cats test ... | 1993 | 8226238 |
| feline bordetellosis: challenge and vaccine studies. | four eight-week-old cats, shown to be free from feline calicivirus, feline herpesvirus and chlamydia psittaci were challenged with an aerosol of bordetella bronchiseptica. within five days the cats developed signs of respiratory disease, characterised by nasal discharge, sneezing, spontaneous or induced coughing and dry or wet rales at auscultation. these signs were present for about 10 days, after which they began to resolve. to test the protective capacity of an experimental fimbrial antigen-b ... | 1993 | 8236648 |
| detection of feline herpesvirus 1 transcripts in trigeminal ganglia of latently infected cats. | | 1993 | 8385921 |