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specific immunity and nonspecific resistance to infection: listeria, protozoa, and viruses in mice and hamsters,.specific immunity developed by mice against protozoan (toxoplasma gondii and besnoitia jellisoni) and bacterial (listeria monocytogenes) infections was compared with nonspecific protection conferred by prior infections. the results indicated that homologous immunity protected mice from more than 10-5 ld50 of t. gondii or b. jellisoni, but from only 10-2 ld50 of l. monocytogenes. heterospecific protection among these organisms was for 10-0.4 minus 10-1.2 ld50. in studies in hamsters specific immu ...1975165241
isolation of equine herpesvirus type 1 from a horse with an acute paralytic disease.a standardbred mare became paralyzed shortly after showing signs of an upper respiratory infection. the mare was euthanized and equine herpesvirus type 1 was isolated from the brain and spinal cord.1975166741
virus-induced abortion. studies of equine herpesvirus 1 (abortion virus) in hamsters.a hamster-adapted strain of equine herpesvirus-1 (equine abortion virus) caused severe hepatic degeneration in both pregnant and nonpregnant hamsters and, in addition, regularly induced abortion in pregnant hamsters inoculated at midgestation. in nonpregnant hamsters, the only consistently affected organ was the liver despite a prolonged viremia. newborn animals usually died 1 to 2 days after inoculation; adults died 5 to 9 days after inoculation. in pregnant hamsters, the virus had a tropism fo ...1975171478
efficacy of 9-beta-d-arabinofuranosylhypoxanthine 5'-monophosphate in therapy of equine abortion virus-induced hepatitis in hamsters.equine abortion virus (eav)-induced hepatitis in hamsters presents an interesting animal model for the evaluation of drugs possessing anti-deoxyribonucleic acid virus activity. these experiments demonstrate that 9-beta-d-arabinofuranosylhypoxanthine 5'-monophosphate (ara-hxmp), a new synthetic, water-soluble, antiviral agent, effectively controls this disease in hamsters with a therapeutic index of approximately 60. ara-hxmp prevented hepatitis-associated deaths in hamsters, reduced the titer of ...1975172009
equine herpesvirus-induced alterations in nuclear rna and dna polymerase activities. 1975173079
transcription of equine herpesvirus type 1: evidence for classes of transcripts differing in abundance. 1975173082
experimental studies on equine herpesvirus type 1 infections.the ehv-1 viruses of fetal origin grew better and had a wider tissue culture host range than those isolated from horses with respiratory diseases. comparisons of a fetal isolate (f/304) and a respiratory disease isolate (r/nm-3) in partly immune horses showed that the f/304 virus infected horses more readily, grew better in the nasopharynx, was more likely to cause abortion, and was excreted to a greater extent into the environment.1975173849
equine herpesvirus in vivo: cyclic production of a dna density variant with repetitive sequences. 1976176793
[developmental stages of herpesvirus-equi-1 in nasal mucosa cells]. 1976176846
purification of equine herpesvirus type 1.a method for the purification of enveloped infectious equine herpesvirus type 1 (ehv-1) is presented. virus from cell culture fluids harvested at 48 h post infection was concentrated by sedimentation and partially purified by differential precipitation with ammonium sulphate. the final steps of purification consisted of two cycles of flotation of virus in pre-formed cscl density gradients. yields of infectious virus were about 30% (18 to 44%) of that present in starting material. as judged by el ...1976177732
abortion associated with mixed leptospira/equid herpesvirus 1 infection. 1976178087
practical aspects of equine virus abortion in the united kingdom.the current knowledge of the clinical signs, epidemiology and pathogenesis of abortion due to the equid herpesvirus (ehv 1) is reviewed. the relationship between the respiratory and abortigenic forms of the disease is discussed as well as the low incidence of virus abortion in the uk compared to some other parts of the world. some practical aspects of the disease as they affect stud management are considered including methods of diagnosis, prophylaxis and the necessary action to be taken to prev ...1976178088
[case of rhinopneumonia in horses in kirghizia]. 1976178089
letter: equine virus abortion. 1976179184
immunity to equine herpesvirus type 1 (rhinopneumonitis): in vitro lymphocyte response.twenty-two ponies were examined for serum-neutralizing (sn) antibody to equine herpesvirus type 1 and for in vitro lymphocyte transformation in the presence of viral antigen. six ponies had undetectable levels of neutralizing antibody (titer less than 1:2) and had lymphocytes which did not respond in culture with viral antigen (stimulation index less than 2.0). four ponies which had sn antibody to equine herpesvirus type 1 did not manifest lymphocyte transformation in vitro. the 12 remaining ser ...1976179451
serological study of an outbreak of paresis due to equid herpesvirus 1 (ehv-1).six cases of paresis occurred in a swedish stud with 48 mares and a stallion. complement-fixation tests revealed a recent infection with ehv-1 in most horses of the stud. serumneutralisation tests showed rapid antibody-titre increases during the course of the disease. this type of antibody response was interpreted as induced by reinfection or, possibly, recurrent infection. two diseased mares were sacrificed. no virus could be isolated from their central nervous system (cns), liver or spleen, bu ...1976181891
letter: isolation and characterisation of equine herpes virus type 1. 1976183339
[infection of hela cells by herpes virus of horses type 1 in different temperature and dose of the virus (author's transl)]. 1976183896
[persistent infection of stable cell cultures by herpes virus of horses type 1 (author's transl)]. 1976183897
infectious causes of equine respiratory disease on ontario standardbred racetracks.upper respiratory disease has been a serious problem in standardbred horses on racetracks in ontario, with outbreaks occurring once or twice annually in late winter and early spring seasons. to determine the causes of these epidemics, a 3-year investigation was carried out in which nasal swabs and serum samples were obtained at intervals from apparently healthy horses and from horses suffering from upper respiratory disease. the nasal swabs were used to isolate bacteria and viruses. the serum sa ...1977192757
equine herpesviruses. 6. sequential infection of horses with types 2, 3 and 1.the immunological and virological status of 3 foals in respect of equine herpesviruses (ehv) was established and the foals were sequentially infected with ehv2, ehv3 and ehv1. following experimental infection with ehv2, no clinical signs of disease were observed in any foal. the inoculation of ehv3 into the genital tract resulted in lesions of the mucous membrane and perineal skin that were considered typical of equine coital exanthema. following intransal inoculation of ehv3 extensive ulceratio ...1976183644
equine herpesvirus 1 infection of horses: studies on the experimentally induced neurologic disease.experimental infection with equine herpesvirus 1 (rhinopneumonitis) resulted in neurologic disease in 8 of 15 inoculated horses. nonpregnant animals did not develop clinical disease, and microscopic examination of tissues revealed no changes. in all mares between 3 and 9 months of gestation, a neurologic syndrome appeared 6 to 8 days after inoculation. mares inoculated when 10 months pregnant did not develop neurologic disorders, but several aborted. the histopathologic change common to both seq ...1977195494
disseminated necrotizing myeloencephalitis: a herpes-associated neurological disease of horses.equine viral rhinopneumonitis type i virus was isolated from spinal cord and brain of a paraparetic horse with disseminated necrotizing myeloencephalitis. necrotic arteriolitis,nonsuppurative necrotizing myeloencephalitis and gasserian ganglioneuritis were present. on record were 12 more cases of horses with similar lesions. the horses had been ataxic or paretic for up to several weeks. a field survey indicated that 14 of 24 horses with acute myelitic signs developed them after recent exposure t ...1976180652
respiratory disease in horses. 1977196170
electrophoretic separation of double-stranded rna genome segments from warrego and mitchell river viruses. 1977196574
antiviral activity of arabinosylthymine in herpesviral replication: mechanism of action in vivo and in vitro.1-beta-d-arabinofuranosylthymine (ara-t), a metabolite of the sponge tethya crypta, has shown selective activity against herpes simplex virus (hsv) replication (g. a. gentry and j. f. aswell, virology 65:294-296, 1975). analysis of hsv-infected and uninfected cell lysates by cscl isopycnic centrifugation showed that ara-t blocked the incorporation of [(3)h]hypoxanthine into viral deoxyribonucleic acid and, to a large extent, into host deoxyribonucleic acid of infected (but not uninfected) cells. ...1977197886
meningoencephalomyelitis in horses associated with equine herpesvirus 1 infection.during an outbreak of abortion caused by equine herpesvirus 1, a neurologic disease characterized clinically by dullness and ataxia occurred in several mares. equine herpesvirus 1 was isolated from brain and lung of two severely affected mares. histologically, both mares had disseminated meningoencephalomyelitis characterized by necrotizing arteritis, focal malacia in grey and white matter of brain and spinal cord, and accumulation of lymphocytes and neutrophils in paravertebral ganglia. eosinop ...1976180650
[equine rhinopneumonitis virus infection in horses. ii (author's transl)]. 1976178066
viral respiratory infections. 1976177853
serological detection of equid herpesvirus 1 infections of the respiratory tract.an investigation was made of 3 serological tests (virus neutralization, complement fixation and indirect immunofluorescence), which are applicable to epidemiological studies of infections by equid herpesvirus 1 (ehv-1). sera from gnotobiotic foals inoculated intranasally with various strains of ehv-1 were unable in some cases to neutralize heterologous strains and these results were not consistent with the existence of clearly-defined subtypes of ehv-1, as previously proposed. the cross-reaction ...1976177281
comparative analyses of the proteins and antigens of five herpesviruses. 1977200709
capsomeres of herpesvirus-equi-l in thin sections. 1976176974
letter: efficacy of modified live-virus equine rhinopneumonitis vaccine. 1976176909
[demonstration of a clinically manifested mixed reovirus serotype iii and rhinopneumonitis virus infection in a horse]. 1978205205
[electron microscopy studies on the multiplication of herpesvirus-equi-1 in brain cells of hamsters]. 1978207056
effects of crude extracts of various plants on infectious bovine rhinotracheitis virus-plaque production.extracts of 28 plants were tested without demonstable antiviral activity in an agar-overlay plaque-reduction antiviral assay system, using infectious bovine rhinotracheitis virus and bovine endocardial cell cultures. ethanolic extract of narcissus tazetta l bulb elicited antiviral activity by inhibition of viral plaque formation. antiviral activity was demonstrated against infectious bovine rhinotracheitis and equine rhinopneumonitis viruses. narcissus tazetta l bulb did not directly inactivate ...1976176907
replication of equine herpesvirus type i: resistance to hydroxyurea. 1975170739
[equine rhinopneumonitis virus infection in horses (author's transl)]. 1975170706
mitochondrial and herpesvirus-specific deoxypyrimidine kinases.to characterize and compare the thymidine (tdr) and deoxycytidine (cdr) kinase isozymes of uninfected and herpesvirus-infected cells: (i) the subcellular distribution of the isozymes has been studied; (ii) a specific assay for cdr kinase has been devised; (iii) the tdr kinase isozymes have been partially purified; and (iv) the purified enzymes have been analyzed by disc polyacrylamide gel electrophoresis, isoelectric focusing, and glycerol gradient centrifugation and by substrate competition and ...1975169387
the prevalence of equid herpes virus 2 infections. 1975167501
immunity and the level of neutralization antibodies in foals and mares vaccinated with a modified live-virus rhinopneumonitis vaccine.foals (farms 1 and 2) and mares (farms 1 and 3) vaccinated with a commercially available rhinopneumonitis vaccine were tested for the level of antibodies and for protection against the natural infection. the serum-neutralization (sn) antibody titers against equine herpesvirus type 1 were 1:8 or less in the majority of foals and 1:16 or higher in about 10%. the level of the nasal secretory antibody in the foals (farm 2) was less than 1:4. the vaccinated foals did not show any apparent respiratory ...1975164808
skin hypersensitivity to equid herpesvirus type 1 in horses. 1978211756
[complement fixation reaction studies in rhinopneumonitis of horses].it was established that the complement binding reaction (cbr) is a suitable and very fast method for horse rhino-pneumonitis diagnostics. cell cultural virus produced in cell cultures of pig kidneys was used as antigen. the antigen lots tested have no anticomplementary properties. highest complement binding activity was evident in the non-diluted antigen, which discovered specific antibodies in immune serums. the cbr specificity was tested by the aid of homologous and heterologous serums and ant ...197994480
antigenic relatedness of equine herpes virus types 1 and 3.antiserums prepared in specific pathogen free (spf) ponies were used in direct and indirect immunofluorescence, immunodiffusion, complement fixation and serum neutralization procedures to study the interrelationships of the three types of equine herpes viruses (ehv-1, ehv-2, and ehv-3). equine cell cultures infected with each type virus fluoresced when stained with homologous conjugated antiserum. in reciprocal tests ehv-1 and ehv-3 cross-fluoresced, but ehv-2 did not cross-fluoresce. non-infect ...197875724
equine viral encephalitis.the most important neurotropic viral infections of the horse are the arthropod-borne encephalitides. these include venezuelan encephalitis (ve), eastern encephalitis (ee) and western encephalitis (we), which are found in the americas, and japanese b encephalitis which occurs in the far east. all the viruses cause encephalitis in man. between 1969 and 1972 an epidemic of ve occurred in central america. in 1971 the disease was reported in texas, where it was brought under control by the vaccinatio ...19764301
equine rhinopneumonitis vaccine: immunogenicity and safety in foals. 1978215062
biological properties of equine herpesvirus type 1 dna: transfectivity and transforming capacity.dna extracted from purified virions of equine herpesvirus type 1 (ehv-1) was examined for its transfectivity and transforming ability. the infectivity of the herpesvirus dna was demonstrated by addition of calcium phosphate-dna coprecipitates to monolayers of permissive horse cells, with resultant plaque formation. the efficiency of transfection (50 to 100 plaque-forming units/microgram of dna) was reduced by treatment of the viral dna with deoxyribonuclease or sonication but not with pronase o ...1978215545
in vitro stimulation of foal lymphocytes with equid herpesvirus 1. 1977195321
ribonucleotide reductase activity in hydroxyurea-resistant herpesvirus replication. 1977195286
purification and characterization of deoxythymidine kinase (dtk) induced in dtk- 3t3 mouse cells by equine herpesvirus type 1 (ehv-1). 1979218350
biological and biochemical properties of defective interfering particles of equine herpesvirus type 1. 1979218357
epidemiology of equine upper respiratory tract disease on standardbred racetracks.the outbreaks of upper respiratory tract infections in horses at standardbred racetracks were investigated over a three year period. the most serious epidemics of respiratory disease occurred in the winter and spring seasons. both influenza viruses and equine herpesvirus 1 were shown to be present in the horse population. the herpesvirus was associated with respiratory disease particularly in the winter but the equine influenza viruses apparently were responsible for the major epidemics of respi ...1979218705
a comparative study of bovine herpesvirus 1247 and equine herpesvirus 1 in ponies.the clinical and immunological response of ponies exposed to a bovine herpesvirus isolate and equine herpesvirus 1 were compared. each virus was inoculated into two ponies by the intranasal route. one uninoculated pony was used with each group as a contact control. the four inoculated ponies developed a mild rhinitis with an increase in rectal temperature. virus was recovered from nasal secretions collected from the four inoculated and one contact pony. all ponies developed a serum neutralizing ...1979218710
protective immunity in equine herpesvirus type i infection of hamsters. 1977194753
effects of equine rhinopneumonitis vaccination on an epizootic of race track cough (tracheopharyngitis). 1977193232
oncogenic transformation of non-permissive murine cells by viable equine herpesvirus type 1 (ehv-1) and ehv-1 dna.primary cultures of balb/c mouse embryo fibroblasts infected with as much as 100 pfu per cell of ehv-1 do not exhibit cytopathology or synthesize detectable amounts of ehv-1 specific rna, dna, or infectious virus. addition of 1--2 microgram of non-fragmented ehv-1 dna as a co-precipitate with calcium phosphate to monolayers of such non-permissive mouse cells resulted in the appearance, after 4--6 weeks, of foci of piled-up, morphologically altered cells. cell lines established from such transfor ...1978221355
herpesvirus transcription: altered regulation induced by fudr. 1977190769
vaccination against diseases associated with herpesvirus infections in animals: a review.an account is presented of the development and use of herpesvirus vaccines in domestic animals, with particular reference to those viruses causing cytolytic rather than oncogenic infections. the chief infections covered are aujeszky's disease (ad or pseudorabies), infectious bovine rhinotracheitis (ibr) and equine rhinopneumonitis (equine abortion; ehv-1). others mentioned are feline viral rhinotracheitis and malignant catarrhal fever of cattle. both live-modified and inactivated vaccines are wi ...1978221416
persistent infection of a human lymphoblastoid cell line with equine herpesvirus 1.infection of a human lymphoblastoid cell line (jijoye line derived from a burkitt lymphoma which contains epstein-barr virus) with equine herpesvirus 1, maintained and observed for 53 days, was characterized by the continuous production of infectious extracellular and intracellular virus. maximum virus production correlated with active cell multiplication. less than 15% of the cells possessed viral capsid antigen at any one time. five percent of the cells in the jijoye line possess epstein-barr ...1979222688
failure to demonstrate equine rhinopneumonitis virus as a cause of abortion in mares in new zealand. 1976190568
equine rhinopneumonitis: more deaths--warning issued. 1979224565
equine rhinopneumonitis outbreak at newmarket. 1979224566
in vitro cytotoxicity of serum and peripheral blood leukocytes for equine herpesvirus type 1-infected target cells.the immune response in horses following experimental infection with equine herpesvirus type 1 (ehv-1) was assessed by measuring cytotoxicity for ehv-1-infected target cells. a technique was developed, using [125i]5-iodo-2'-deoxyuridine ([125i]iudr)-labeled equine fetal kidney cells infected with ehv-1 as the target cells. it was shown that peripheral blood leukocytes from a recovered horse were capable of lysing target cells, as measured by the loss of radio-active label. following the experimen ...1977189645
antigenic comparisons between herpesviruses isolated from fallow deer in alberta and the viruses of infectious bovine rhinotracheitis, equine rhinopneumonitis and dn-599, a non-ibr bovine herpesvirus.antigenic comparison studies of three herpesviruses isolated from fallow deer (dama dama) in alberta and herpesviruses from some domestic species were carried out by the alpha serum-virus neutralization test. complete cross neutralization was demonstrated among the deer herpesviruses and equine herpesvirus type 1.1979225575
[combined vaccination plan against influenza, equine rhinopneumonitis and tetanus for thoroughbred horses]. 1976183944
neurologic disease induced by equine herpesvirus 1. 1979227824
epidemiology of equine infectious respiratory disease. 1979228462
viral respiratory disease. 1979228463
newmarket outbreak: indirect contacts to be traced. 1979228468
[several years of diagnostic studies on the ehv 1 abortion in thoroughbred studs following the introduction of vaccination]. 1977195571
equine rhinopneumonitis virus (herpesvirus type 1): attenuation in stable monkey cell line.an isolate of virulent equine herpesvirus (ehv) type 1 was adapted to vero stable cell line by 13 serial passages at 37 c and 50 serial passages at 26 c. characteristics of the attenuated ehv-1 were found to be avirulent, but immunogenic in horses if injected intramuscularly. the attenuated virus was regularly isolated from peripheral leukocytes in inoculated horses, but was not recovered from nasal turbinate tissues. a mild leukopenia was noticed. the attenuated virus produced characteristic la ...1977199093
safety of rhinoquintm, rhinopneumonitis vaccine in foals and pregnant mares. 1977199978
cell mediated immunity in equine herpesvirus type 1 infection i. in vitro lymphocyte blastogenesis and serum neutralization antibody in normal parturient and aborting mares.blastic transformation of peripheral blood mononuclear cells and serum neutralization antibody levels for equine herpesivurs type 1 were measured in 19 mares from three farms at the time of termination of their pregnancy by normal foaling or viral abortion. the stimulation indexes of lymphocytes obtained from the mares from two farms (farm 1 and 2) which had virus abortions, ranged from 2.1 to 10.8. but there was no significant difference in stimulation index levels between the aborting and norm ...1977200317
purification and biochemical characterization of deoxythymidine kinase of deoxythymidine kinase-deficient mouse 3t3 cells biochemically transformed by equine herpesvirus type 1.a line of mouse 3t3 cells lacking deoxythymidine kinase (dtk-) was stably transformed to see dtk+ phenotype after exposure to ultraviolet-irradiated equine herpesvirus type 1 (ehv-1). deoxythymidine kinase (dtk) was purified from the biochemically transformed mouse cells by affinity chromatography on deoxythymidine-sepharose. the purified dtk from ehv-1-transformed 3t3 cells was identical to the dtk purified from dtk- 3t3 cells lytically infected with ehv-1 with respect to its electrophoretic mo ...1979489123
effect of age and pregnancy on the antibody and cell-mediated immune responses of horses to equine herpesvirus 1.the cell-mediated immune response and antibody response of horses of varying ages and of pregnant horses to equine herpesvirus 1 antigen were examined. six to eight month old horses showed either no increase or slight increases in anti-equine herpesvirus 1 serum neutralizing antibody following vaccination and revaccination with a modified live equine herpesvirus 1 vaccine. however, these same horses showed a marked increase in the cell-mediated immune response to equine herpesvirus 1 as measured ...1977200320
genetic relatedness of equine herpesvirus types 1 and 3.the genetic relatedness of two types of equine herpesviruses (ehvs), 1 (ehv-1) and 3 (ehv-3), was determined by dna-dna reassociation kinetics. denatured, labeled viral dna probe was allowed to reassociate in the presence or absence of the second unlabeled viral dna. the initial rate of reassociation of either labeled viral dna was increased by the presence of the heterologous viral dna to an extent indicating only 2 to 5% homology between the two ehv genomes. moreover, labeled rna extracted fro ...1977201775
equine rhinopneumonitis vaccine: immunogenicity and safety in adult horses, including pregnant mares. 1978205144
perinatal foal mortality associated with a herpesvirus. 1977207253
generalised congenital equine herpes virus infection in a neonatal foal. 1977207256
measurement of neutralizing antibody to equid herpesvirus 1 by single radial hemolysis.antibody to equid herpesvirus 1, which mediates single radial hemolysis, is that responsible for neutralization. hemagglutination inhibition antibody is not necessarily involved in neutralization or hemolysis.1978207720
the protective antigens of equine herpesvirus type 1.equine herpesvirus type 1 was cultivated in swine testis cell cultures and partially purified by differential centrifugation and centrifugation in a linear sucrose density gradient. the viral envelope was separated from the nucleocapsid by treatment with rexol 25j followed by sucrose gradient centrifugation. the envelope and nucleocapsid preparations were then electrophoresed in polyacrylamide gel after solubilization with sodium dodecyl sulphate. hamsters were immunized with various preparation ...1978208736
natural intra-uterine infection of foals with equine herpes virus type 1 in victoria. 1978210752
equine abortion associated with herpesvirus. 1978210753
biochemical transformation of deoxythymidine kinase-deficient mouse cells with uv-irradiated equine herpesvirus type 1.a line of 3t3 mouse cells lacking deoxythymidine kinase (dtk-) was stably transformed to the dtk+ phenotype after exposure to uv-irradiated equine herpesvirus type 1 (ehv-1). biochemical transformants were isolated in a system selective for the dtk+ phenotype (eagle minimal essential medium containing 10(-4) m hypoxanthine, 6 x 10(-7) m aminopterin, and 2 x 10(-5) m deoxythymidine). transformation was accompanied by the acquisition of a dtk activity with immunological, electrophoretic, and bioch ...1978212607
induction of deoxythymidine kinase activity in several mammalian cell lines after infection with six different strains of equine herpesvirus type 1 (ehv-1). 1978214953
proteins of equine herpesvirus type 3. i. polypeptides of the purified virion. 1979217165
prevalence of antibodies to equine viruses in the netherlands.the prevalence of antibodies to various viruses was investigated in a series of serum samples collected from horses in the netherlands between 1963 and 1966 and from 1972 onwards. neutralizing antibodies to equine rhinopneumonitis virus, equine arteritis virus and to equine rhinovirus types 1 and 2 were detected in respectively 76%, 14%, 66% and 59% of the equine serum samples tested. the observed incidence of serum samples positive to equine adenovirus in the complement fixation test was 39%. p ...1979219560
viral induced cytopathic effect & release of lysosomal enzyme. 1978220188
arabinosylthymine: in vivo effectiveness in a systemic herpesvirus infection. 1978221367
differentiation of field strains and a vaccine strain of equine herpesvirus 1, using plaque characteristics. 1979223480
immunity to equine herpesvirus 1 infection in foals during the first year of life.a band of 23 pregnant mares on a thoroughbred breeding farm all had serum virus-neutralizing antibody titres to equine herpesvirus 1 (ehv-1). antibody was not transferred to their foals in utero. all foals received antibody from colostrum and developed antibody titres similar to their dams. the serum virus-neutralizing antibody titres were observed in 10 of these foals for 1 year. decay of passive immunity occurred at the rate of 3.25 two-fold dilutions in 100 days and reached zero at the mean t ...1979225497
equine herpesvirus 1 infection in mares vaccinated with a live-virus rhinopneumonitis vaccine attenuated in cell culture.vaccination, in july and again in either november or december 1976, of 55 pregnant standardbred mares with a live-virus rhinopneumonitis vaccine attenuated in cell culture failed to protect some mares from infection with equine herpesvirus 1. from 1976-12-08 to 1977-03-08, 33 mares foaled healthy foals, 16 mares foaled dead foals or live foals which died usually within 48 hours and six mares aborted. gross and histological examinations and virus isolation studies confirmed that equine herpesviru ...1979226261
[central nervous system form of rhinopneumonitis virus infection]. 1979231877
equine herpesviruses: on the differentiation of respiratory from foetal strains of type 1. 1979231960
an outbreak of foal perinatal mortality due to equid herpesvirus type 1: pathological observations.twenty-nine cases of ehv1 infection occurred on a property, mainly in full term foals. some foals were stillborn, some were born alive but weak and soon died and others were healthy at birth, became ill and died within 3 days of birth. apart from voluminous, oedematous and atelectic lungs there were no gross lesions. microscopically the lungs showed oedema, pneumonitis and bronchiolitis with intranuclear inclusions and, in many of the foals that survived over 6 hours, there was also hyaline memb ...1979232044
herpesvirus-induced availability of host dna to exogenous endonuclease.deoxyribonuclease i penetrates herpesvirus-infected l cells and degrades host dna without interfering with viral multiplication. the dna of uninfected control monolayers of l cells, disrupted by scraping, is similarly attacked. in contrast, undisturbed l cells are not affected. this suggests that altered cell membrane permeability allows the nuclease to enter the cell, thereby permitting access of exogenous deoxyribonuclease to cellular dna.1975241244
the virus neutralizing activity of antibodies specific to the envelope and nucleocapsid of equine herpesvirus type 1.antibodies specific to the envelope or nucleocapsid of the kentucky-d strain of equine herpesvirus type 1 were isolated from convalescent horse serum by immunoadsorption on cyanogen bromide-activated sepharose conjugated with equine herpesvirus type 1 envelopes or nucleocapsids, with subsequent elution by glycine buffer. in double immunodiffusion and immunolectrophoresis reactions, the eluted proteins appeared to belong to the igg fraction of horse serum. antibodies directed against the viral en ...1979497891
replication of equine herpesvirus type 1 and type 3: resistance to hydroxyurea and thymidine.the replication of equine herpesvirus type 1 (ehv-1) and type 3 (ehv-3) was unimpeded in three different cell types-equine epithelial cells, equine fibroblasts, and mouse fibroblasts-which had been blocked in their capacity to synthesize host dna by 2.5 mm hydroxyurea (hu) or 2 mm thymidine (tdr). the rate of dna synthesis in uninfected or equine herpesvirus-infected cells in the presence of hu or tdr was measured by pulse-labeling cell samples with a labeled dna precursor at different times aft ...1978563855
characterization of three species of nucleocapsids of equine herpesvirus type-1 (ehv-1). 19751167720
glycoprotein 60 of equine herpesvirus type 1 is a homologue of herpes simplex virus glycoprotein d and plays a major role in penetration of cells.monoclonal antibodies (mabs) specific for equine herpesvirus type 1 (ehv-1) glycoprotein 60 (gp60) and gp 17/18 (f3132 and 5h6 respectively) were found to react with the same protein, which was identified as a homologue of herpes simplex virus type 1 gd. mab f3132 strongly neutralized virus infectivity and inhibited the penetration of the virus into the cell. the effects on penetration were shared with three other mabs against this protein (p68, f3116 and f3129), but no effect on virus penetrati ...19921321875
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