| myxomatosis on the western plains of victoria. | myxomatosis on the western plains is an enzootic disease in contrast with the epizootic pattern which is general in eastern australia. the most unusual aspects are the presence of significant numbers of diseased rabbits throughout the winter and the continuously low percentage of rabbits with antibodies to myxoma virus. climatic and topographic conditions are unsuited to the production of the high densities of mosquitoes necessary for widespread epizootics. under these conditions the effects of ... | 1977 | 20473 |
| the effects of temperature and ph variations on plaque production by different virulence types of myxoma virus. | eight 'strains' of myxoma virus, spanning the complete spectrum of virulence, were tested for ability to produce plaques on rabbit kidney cells at varying temperatures and ph values. a positive correlation was found between virulence in rabbits and ability to produce plaques at supra-optimal temperature and at low ph. | 1979 | 39114 |
| immune and non-immune macrophage resistance to the fibroma-myxoma virus complex. | | 1975 | 168379 |
| preliminary studies on an unusual poxvirus of the western grey squirrel (sciurus griseus griseus) of north america. | particles of a poxvirus found in californian western grey squirrels have overall dimensions indistinguishable from those of the poxviruses of the genera orthopoxvirus and leporipoxvirus, but have surface structures somewhat reminiscent of virions of members of the genus parapoxvirus. extracts of tissues infected with the squirrel poxvirus cross-react in gel-diffusion tests with extracts of tissues infected with californian myxoma virus, but not with a similar preparation infected with a south am ... | 1975 | 181346 |
| myxomatosis: the transmission of a highly virulent strain of myxoma virus by the european rabbit flea sphilopsyllus cuniculi (dale) in the mallee region of victoria. | the european rabbit flea spilopsyllus cuniculi (daley was introduced into australia to act as a vector of myxoma virus. it was first released in the semi-arid mallee region of victoria in 1970 where epizootics cuased by field strains of myxoma virus occur each summer. introductions of the readily identified lausanne strain were made annually following the release of the flea. the introductions were successful and the strain persisted for up to 16 weeks despite competition from field strains. the ... | 1977 | 270525 |
| innate resistance to myxomatosis in wild rabbits in england. | wild rabbits (oryctolagus cuniculus) from one study area in england have been used over a period of 11 years to investigate the possible appearance of innate resistance to myxomatosis. rabbits of 4-6 weeks old were captured alive, retained in the laboratory until at least 4 months old, and then infected with a type of myxoma virus which kills 90-95% of laboratory rabbits. observations were made of symptoms, mortality rate and survival times.in the first 4 years of the study (1966-9), mortality r ... | 1977 | 270526 |
| myxomatosis: changes in the epidemiology of myxomatosis coincident with the establishment of the european rabbit flea spilopsyllus cuniculi (dale) in the mallee region of victoria. | outbreaks of myxomatosis during the winter or spring have coincided with the establishment of the european rabbit flea in the mallee region. the severity of these outbreaks has varied from causing complete suppression of the normal spring increase in rabbit numbers to being completely ineffective in a year in which late spring rains allowed rabbit breeding to extend into the early summer.in 1973 and 1974 effective spring myxomatosis caused heavy mortality in kittens before they emerged from the ... | 1978 | 569676 |
| myxomatosis in the mallee region of victoria, australia. | sharp reductions in the wild rabbit (oryctolagus cuniculus (l.)) population in the mallee are associated with annual myxomatosis epizootics. the extent to which the population reductions are the direct result of the epizootics varies with time of epizootic occurrence. all grazing animals in the mallee are under nutritional stress each summer and autumn. when the epizootic occurs during the early summer heavy losses occur in a previously healthy population. similar losses which occur in the late ... | 1978 | 701787 |
| myxomatosis: the occurrence of antibody to a soluble antigen of myxoma virus in wild rabbits, oryctolagus cuniculus (l.), in victoria, australia. | the occurrence of antibody of myxoma virus in wild rabbits following epizootics is highest in the semi-arid north-west of victoria and lowest in temperate southern victoria. occurrence ranges up to about 90% in the north-west and to about 70% in the south except on the western plains where epizootics are rare and antibody occurrence seldom exceeds 30%. the establishment of the european rabbit flea may be changing the pattern of occurrence of antibody in the north-west by causing spring outbreaks ... | 1978 | 701788 |
| myxomatosis: passive immunity in the offspring of immune rabbits (oryctolagus cuniculus) infested with fleas (spilopsyllus cuniculi dale) and exposed to myxoma virus. | kittens with maternal antibodies to myxoma virus, the offspring of rabbits which had recovered from myxomatosis, were exposed to fleas contaminated with myxoma virus and/or contact with infected rabbits from birth. all kittens died or became infected before 8 weeks of age. when compared with adult animals similarly infected the kittens showed no advantage in terms of survival time or recovery rate attributable to maternal antibodies. flea transmission of virus was found more effective than conta ... | 1975 | 1054058 |
| myxomatosis: the virulence of field strains of myxoma virus in a population of wild rabbits (oryctolagus cuniculus l.) with high resistance to myxomatosis. | the virulence of field strains of myxoma virus is increasing in the mallee region of victoria where the resistance of the rabbit to myxomatosis is high. this suggests that the climax association will be a moderately severe disease. | 1975 | 1056963 |
| myxomatosis: population dynamics of rabbits (oryctolagus cuniculus linnaeus, 1758) and ecological effects in the united kingdom. | in 1953-1955, myxomatosis spread among rabbits (oryctolagus cuniculus) in the united kingdom, causing 99% mortality. subsequently, there was a gradual increase in rabbit numbers. by 1955, the ministry of agriculture, fisheries and food (maff) had already found attenuated strains of myxoma virus. by 1970, genetic resistance had appeared. in the 1970s, mortality declined to 47-69% with only approximately 25% of rabbits infected, giving a field mortality of 12-19%. however, myxomatosis is persisten ... | 1992 | 1305856 |
| a myxoma virus intergenic transient dominant selection vector. | the purpose of this study was to construct an intergenic transfer vector which can be used for the generation of recombinant myxoma viruses (mvs) expressing a foreign gene insert. recombinant mvs expressing the escherichia coli lacz gene were constructed in vitro by transfection of mv-infected rabbit cells with a transfer expression vector, and isolated under growth conditions selecting for transient expression of the e. coli gpt gene. the effect of inserting foreign dna sequences between the vi ... | 1992 | 1469364 |
| the myxoma virus thymidine kinase gene: sequence and transcriptional mapping. | the myxoma virus thymidine kinase (tk) gene is encoded on a 1.6 kb saci-sali restriction fragment located between 57.7 and 59.3 kb on the 163 kb genomic map. the nucleotide sequence of this fragment as well as 228 bp from the adjacent sali-aa2 fragment was determined and found to encode four major open reading frames (orfs). three of these orfs are similar in nucleotide sequence to orfs l5r and j1r, and the tk gene of vaccinia virus (vv). the fourth orf, mf8a, shows similarity to the orfs found ... | 1992 | 1538190 |
| myxomatosis vaccine. | | 1992 | 1609472 |
| molecular analysis of immunosuppression induced by virus replication in lymphocytes. | the relationship between immunosuppression and oncogenesis can be determined by studying the molecular interactions between tumor-inducing viruses and lymphocytes. we approached this study by using a unique system of two genetically related leporipoxviruses, malignant fibroma virus (mv), and shope fibroma virus (sfv). mv induces a syndrome of a highly lethal, disseminated myxosarcoma, severe immune suppression, and replicates in lymphocytes both in vivo and in vitro. in contrast, sfv causes a be ... | 1990 | 2159037 |
| a myxoma virus nucleotide sequence with homology to the vaccinia virus rna polymerase 22-kda subunit gene. | | 1990 | 2402456 |
| isolation and plaque purification of a syncytial forming component of myxoma virus. | using the endpoint dilution and plaque purification technique performed on rabbit kidney cells, two stable syncytial clones of myxoma virus have been isolated. no eosinophilic intracytoplasmic inclusion bodies nor intranuclear granulations could be detected in cells infected with these clones. traditional plaques with the central area of detached cells surrounded by round cells also could not be recognized. however, when enough virus was added, one large complete syncytium developed in 24 on the ... | 1989 | 2582742 |
| vaccinia virus encodes a family of genes with homology to serine proteinase inhibitors. | nucleotide sequencing of a region of the vaccinia virus genome proximal to the right inverted terminal repeat (itr) identified two open reading frames (orfs) encoding proteins of 39k and 40k with amino acid homology to each other, to another vaccinia virus gene near the opposite end of the virus genome and to the superfamily of serine proteinase inhibitors (serpins). serpins have now been found in poxviruses from the genera orthopox (cowpox and vaccinia viruses), leporipox (myxoma virus) and avi ... | 1989 | 2778436 |
| myxomatosis in farmland rabbit populations in england and wales. | the overall pattern and consequences of myxomatosis in wild rabbit populations were studied at three farmland sites in lowland southern england and upland central wales between 1971 and 1978. when results from all years were combined, the disease showed a clear two-peaked annual cycle, with a main autumn peak between august and january, and a subsidiary spring peak during february to april. rabbit fleas, the main vectors of myxomatosis in britain, were present on full-grown rabbits in sufficient ... | 1989 | 2806418 |
| high levels of genetic recombination among cotransfected plasmid dnas in poxvirus-infected mammalian cells. | the frequency of recombination between transfected plasmid dnas was measured by using cultured cells infected with a variety of poxviruses. plasmid derivatives of pbr322 containing xhoi linker insertion mutations in the tetracycline gene were used to assess recombination frequencies in rabbit cells infected with the leporipoxviruses shope fibroma virus and myxoma virus and the orthopoxvirus vaccinia virus. recombination frequencies were calculated by southern blotting, which detects novel plasmi ... | 1988 | 2826801 |
| tumorigenic poxviruses: fine analysis of the recombination junctions in malignant rabbit fibroma virus, a recombinant between shope fibroma virus and myxoma virus. | malignant rabbit fibroma virus (mrv) has been shown to be a lethal tumorigenic poxvirus of rabbits derived from a recombination event between shope fibroma virus (sfv), which induces benign fibromas in rabbits, and myxoma virus, the agent of myxomatosis. we have cloned and sequenced all of the mrv recombination junctions, which are located near the left and right terminal inverted repeat (tir) regions, and present a composite map of the mrv genome with respect to the relevant gene products. the ... | 1988 | 2842947 |
| transcriptional mapping of early rna from regions of the shope fibroma and malignant rabbit fibroma virus genomes. | malignant rabbit fibroma virus (mv) is a recombinant poxvirus derived from shope fibroma virus (sfv) and rabbit myxoma virus (d. s. strayer, e. skaletsky, g. f. cabirac, p. a. sharp, l. b. corbeil, s. sell, and j. l. leibowitz, 1983a, j. immunol. 130, 399-404; w. block, c. upton, and g. mcfadden, 1984, virology 140, 113-124). we report here the transcriptional mapping of early rnas transcribed from the sfv sequences within mv and from the corresponding regions in sfv. hybridization analysis and ... | 1986 | 3016986 |
| [some humoral factors in human saliva having antiinfectious activities due to chemical properties]. | | 1967 | 4188193 |
| inhibition of plaque formation by myxoma and fibroma viruses with pyrimidine analogues. | | 1965 | 4221716 |
| the cytopathic effects of tumor viruses in human diploid cells. similarity with lesions of irradiated cells. | | 1965 | 4285988 |
| possible windborne spread of myxomatosis to england in 1953. | an analysis of the meterological conditions showed that the first outbreaks of myxomatosis in s.e. england in 1953 could have resulted from wind carriage of insects infected with myxoma virus from northern france. south-easterly winds on the night 11-12 august would have carried the insects 120-160 km from the départements of nord, pas de calais and somme across the english channel to near edenbridge, kent. the flight would have taken 6.5-8.5 h at wind speeds of 15-22 km h-1. on the night 11-12 ... | 1987 | 2881798 |
| [experimental study of murine yoshida sarcoma]. | | 1967 | 4294406 |
| [the classification of the virus]. | | 1967 | 4298384 |
| cloning and molecular characterization of the myxoma virus genome. | restriction enzyme cleavage maps of the genomes of the uriarra (ur), glenfield (gv), and lausanne (lu) strains of myxoma virus were deduced for the enzymes ecori, kpni, bamhi, sali, hindiii, bgli, psti, and pvuii. restriction maps for the three strains were indistinguishable with the exception of an additional kpni site in the lu genome at map position 38.8. genomic dna fragments were cloned into the plasmid vector pgem-3 and the viral genome was determined to be 163.6 (+/- 0.2) kb in length. co ... | 1989 | 2718379 |
| survival of a patient with an infected right atrial myxoma following surgery. | | 1989 | 2702973 |
| effect of persistent fibroma virus infection on susceptibility of cells to other viruses. | shope fibroma virus establishes a persistent cytoplasmic infection in primary (rk) and serially cultivated (drk(3)) rabbit kidney cells which is accompanied by a morphological alteration of the cells. the response of such cells to superinfection by other viruses was compared with that of control cells by determining plaque production and virus yield of superinfecting viruses. it was found that the growth of other poxviruses, myxoma and vaccinia, was greatly inhibited in the fibroma virus-infecte ... | 1970 | 4317346 |
| [virus sensitivity of cells cultured from normal or pathologic rabbit tissue]. | | 1971 | 4323151 |
| antiviral activity of l-asparaginase. | | 1971 | 4328211 |
| viral infections of the skin and mouth: a selected review. | | 1971 | 4329250 |
| the group selection of variola minor in the americas: an anthroponootic analogue for the myxomatosis epizootic in australia. | it is an axiom of many parasitology texts that host-parasite systems coevolve toward a state approximating commensalism. while this hypothesis has an apriori intuitive appeal there is little empirical evidence to support it. the only documented case of a parasite evolving toward avirulence is the group selection of less virulent strains of the myxoma virus in the australian rabbit population. it is hypothesized here that group selection also accounted for the appearance of variola minor in the a ... | 1986 | 2423858 |
| enzymes specified by dna-containing animal viruses. in: strategy of the viral genome. | | 1971 | 4337203 |
| characteristics and viral susceptibility of an embryo cell line from marmosa mitis. | | 1972 | 4344268 |
| some aspects of the morphogenesis of myxoma virus in vivo. | | 1972 | 4345949 |
| dna virus inhibitory activity of 1- -d-arabinofuranosylcytosine-3',5'-cyclic phosphate. | | 1973 | 4349901 |
| synthesis and anti-deoxyribonucleic acid virus activity of certain 9-beta-d-arabinofuranosyl-2-substituted adenine derivatives. | | 1974 | 4358433 |
| fifty years with viruses (christopher h. andrewes). | | 1973 | 4361624 |
| [residual moisture of lyophilized biopreparations and its influence on effectiveness]. | | 1974 | 4365255 |
| absence of serological evidence of myxoma virus infection in humans exposed during an outbreak of myxomatosis. | | 1966 | 4381646 |
| mechanism of perpetuation of animal viruses in nature. | | 1969 | 4392000 |
| myxoma virus and malignant rabbit fibroma virus encode a serpin-like protein important for virus virulence. | the leporipoxviruses shope fibroma virus (sfv), the myxoma virus (myx), and the sfv/myx recombinant malignant rabbit fibroma virus (mrv) are closely related yet induce profoundly different diseases in the european rabbit. sfv, which produces a benign tumor at the site of inoculation, is cleared by the immune system after approximately 2 weeks whereas myx and mrv induce a rapidly lethal systemic infection characterized by generalized suppression of host immune functions. dna sequencing studies re ... | 1990 | 2173255 |
| transmissible fibroma of grey squirrels (a case report). | | 1973 | 4491128 |
| wallace p. rowe lecture. poxviruses of laboratory animals. | currently the subfamily chordopoxvirinae, the poxviruses of vertebrates, is subdivided into eight genera, containing some 20-30 species; an inexact figure because the birdpox viruses have not yet been properly investigated taxonomically. i have discussed seven species belonging to three genera, all of which have caused infection and usually disease in mammals commonly used in the laboratory. the list could have been extended had i included chickens and swine as laboratory animals, for that would ... | 1990 | 2170745 |
| synthesis and structure-activity study of myxoma virus growth factor. | myxoma virus growth factor (mgf) is an 85-residue peptide derived from the gene product of a dna tumor virus that infects rabbits. the carboxyl domain of mgf possesses about 40% sequence homology with the epidermal growth factor (egf). this egf-like domain covering residues 30-83 was synthesized and found to possess putative activities of egf. it was, however, about 200-fold less active than egf in the competitive binding of egf receptor in a431 cells and the stimulation of [3h]-thymidine uptake ... | 1991 | 2009268 |
| myxoma virus expresses a secreted protein with homology to the tumor necrosis factor receptor gene family that contributes to viral virulence. | poxviruses are known to contain a large number of open reading frames, particularly near the termini of the viral genome, that are not required for growth in tissue culture. however, many of these gene products are believed to play important roles in determining the virulence of the virus by modulating the host immune response to the infection. recently it has been shown that shope fibroma virus encodes, within the terminal inverted repeats, a protein (t2) related to the cellular tumor necrosis ... | 1991 | 1651597 |
| deletion analysis of two tandemly arranged virulence genes in myxoma virus, m11l and myxoma growth factor. | myxoma virus (myx) is a leporipoxvirus of rabbits that induces a lethal syndrome characterized by disseminated tumorlike lesions, generalized immunosuppression, and secondary gram-negative bacterial infection. a myx deletion mutant (vmyx-gf- delta m11l) was constructed to remove the entire myxoma growth factor (mgf) coding sequence and that for the c-terminal five amino acids of the partially overlapping upstream gene, m11l. unexpectedly, this deletion completely abrogates the capacity of myx to ... | 1992 | 1629952 |
| [role of the ergastoplasm in the morphogenetic cycle of a virus from a myxoamtosis strain]. | | 1972 | 4631977 |
| a myxoma virus epizootic in a brush rabbit population. | | 1972 | 4634525 |
| isolation and characterization of a rabbit fibroma virus from a naturally occurring tumor. | | 1974 | 4809601 |
| encoding of a homolog of the ifn-gamma receptor by myxoma virus. | many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. the major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the m-t7 open reading frame. this protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (ifn-gamma). furthermore, the myxoma m-t7 protein specifically binds rabbit ifn-gamma and inhibits the biological activity of extracellular ifn-gamma, one of th ... | 1992 | 1455233 |
| [particular genetic characteristics of a mutant of sanarelli virus obtained by passages in cellular culture]. | | 1968 | 4967262 |
| characteristics of cell culture systems. viral flora of rabbits. | | 1968 | 4976861 |
| [gel filtration chromatography of myxomatosis virus]. | | 1970 | 4985482 |
| [study of attenuated strain of myxoma virus]. | | 1970 | 4992294 |
| myxomatosis and the rabbit. | | 1972 | 5033312 |
| azapurine nucleosides. 2. synthesis and antiviral activity of 7-amino-3- -d-arabinofuranosyl-v-triazolo (4,5-d)pyrimidine and related nucleosides. | | 1972 | 5065785 |
| [viral myositis]. | | 1971 | 5097703 |
| studies in the epidemiology of myxomatosis in california. iv. the susceptibility of six leporid species to californian myxoma virus and the relative infectivity of their tumors for mosquitoes. | | 1971 | 5166039 |
| the epidemic potential of brazilian myxoma virus (lausanne strain) for three species of north american cottontails. | | 1971 | 5166040 |
| myxoma virus m11l orf encodes a protein for which cell surface localization is critical in manifestation of viral virulence. | myxoma virus (myx) induces extensive immunosuppression in infected rabbits and is associated with high levels of mortality. the virus encodes multiple gene products designed to circumvent the cellular immune response to the viral infection. deletion analysis has shown that the m11l open reading frame (orf) is an important virulence factor which downregulates leukocyte infiltration of myx-induced tumors. to investigate the role of the m11l protein in viral pathogenesis, we sequenced the myx m11l ... | 1992 | 1413498 |
| virus-induced loss of class i mhc antigens from the surface of cells infected with myxoma virus and malignant rabbit fibroma virus. | shope fibroma virus (sfv) is a leporipoxvirus that causes localized benign fibromas in immunocompetent adult rabbits that spontaneously regress due, in part, to a cell-mediated immune response. myxoma virus (myx) and malignant rabbit fibroma virus (mrv) are related leporipoxviruses that induce rapidly lethal generalized infections accompanied by tumors and immunosuppression. because only these latter two viruses are known to compromise cell-mediated antiviral responses, cell surface levels of cl ... | 1992 | 1309843 |
| myxomatosis: the introduction of the european rabbit flea spilopsyllus cuniculi (dale) into wild rabbit populations in australia. | 1. the european rabbit flea spilopsyllus cuniculi (dale) bred successfully in wild rabbits on three properties in new south wales and, within two breeding seasons, almost every rabbit shot within a quarter of a mile of a release site was infested.2. it was demonstrated that the flea transmitted myxoma virus in the field.3. in areas where more than 75% of the rabbits shot at the beginning of the breeding season were flea-infested and myxoma virus was present, populations failed to show the expect ... | 1971 | 5285938 |
| [gel filtration of myxomatosis virus. analytical study of viral particles]. | | 1970 | 5503580 |
| deletion of the growth factor gene related to egf and tgf alpha reduces virulence of malignant rabbit fibroma virus. | the role of the epidermal growth factor homologue in malignant rabbit fibroma virus (mrv) pathogenicity was investigated by constructing a viral growth factor deletion mutant (mrv-gf-). since mrv is a recombinant virus with a myxoma virus background but possesses some terminal sequences derived from shope fibroma virus, the growth factor gene in mrv is in fact identical to shope fibroma growth factor (sfgf). although no significant differences were detected in the in vitro characteristics of mrv ... | 1992 | 1309274 |
| [myxomatosis of rabbits--study of virus modification]. | | 1970 | 5516854 |
| [on a strain of sanarelli virus attenuated by passage through cell cultures]. | | 1967 | 5595260 |
| the isolation of a myxo type virus from two human sarcomas. | | 1968 | 5674822 |
| population regulation and genetic feedback. evolution provides foundation for control of herbivore, parasite, and predator numbers in nature. | | 1968 | 5732485 |
| some biological properties of a virus isolated from a hare tumour. | | 1968 | 5734620 |
| [the myxovirus envelope studied by observing the effect of streptomyces albus g caseinase c on influenza virus pr 8]. | | 1968 | 5742394 |
| myxomatosis and the rabbit flea. | | 1965 | 5885852 |
| effect of sodium bicarbonate upon myxoma virus plaque morphology. | | 1966 | 5918952 |
| [subviral agents of rabbit myxoma and shope fibroma viruses]. | | 1966 | 6005852 |
| the differential transmissibility of myxoma virus strains of differing virulence grades by the rabbit flea spilopsyllus cuniculi (dale). | laboratory studies showed that few rabbit fleas (spilopsyllus cuniculi (dale)) transmitted myxomatosis after removal from wild rabbits (oryctolagus cuniculus (l) that had been infected for fever than 10-12 days, irrespective of the virulence of the myxoma virus strain involved. rabbits infected with fully virulent (grade i) strains died within 10-15 days and few fleas from these hosts became infective; averaging all the samples takem. 12% of the fleas were infective. also, few fleas acquired inf ... | 1975 | 1058245 |
| [study of an attenuated strain of infectious myxoma virus obtained by passage in cell cultures (mackercher and saito, 1964)]. | | 1967 | 6055855 |
| serological relationships between poxviruses of different genera: studies with vaccinia virus and myxoma virus. | | 1981 | 6172453 |
| an immunological method to determine antigenic variation in three strains of myxoma virus. | a technique is described for the purification of soluble antigens of three strains of myxoma virus. radioimmunoassays were used to study the antigenic differences between the three strains. results show that the soluble antigens isolated from lu and g.v. strains do not cross-react in rabbits tested, suggesting that rabbits infected with lu and g.v. strains of the myxoma virus can be readily distinguished. antigen isolated from the u.f.s. strain cross-reacted with sera from both lu- and g.v.-infe ... | 1982 | 6183284 |
| immunologic dysfunction during viral oncogenesis. i. nonspecific immunosuppression caused by malignant rabbit fibroma virus. | malignant rabbit fibroma virus (mv) is a potent oncogenic poxvirus that produces a rapidly progressive syndrome of disseminated myxosarcoma, immunosuppression, and fatal gram-negative infection. mv is probably a recombinant between shope fibroma virus (sfv) and rabbit myxoma virus, and is capable of preventing or aborting the in vitro proliferative responses of rabbit lymphocytes to b and t lymphocyte mitogens. proliferative responses to sheep erythrocytes (srbc) are similarly affected, although ... | 1983 | 6195270 |
| immunohistology of malignant rabbit fibroma virus--a comparative study with rabbit myxoma virus. | malignant rabbit fibroma virus (mv) causes a syndrome that consists of disseminated malignant tumors and immunosuppression complicated by severe pasteurella multocida infection and death. tissues from rabbits given mv and rabbit myxoma virus were examined by direct immunofluorescence with the use of antibody against virus antigens. primary and metastatic tumors caused by mv and rabbit myxoma virus were composed of soft tissue cells containing virus antigens. skin appendages and epidermis overlyi ... | 1983 | 6306322 |
| malignant rabbit fibroma virus: observations on the culture and histopathologic characteristics of a new virus-induced rabbit tumor. | the clinical, histopathologic, and cultural characteristics of a newly isolated poxvirus, malignant rabbit fibroma virus (mv), were investigated. mv was isolated from tumors induced by an uncloned stock of shope fibroma virus (sfv). mv, sfv, and rabbit myxoma virus were compared. similarly to myxoma virus, mv grew to higher titer in vitro than did sfv and produced plaques rather than foci on rabbit kidney cell monolayers. unlike the local, self-limited fibroblastic proliferations observed in sfv ... | 1983 | 6306326 |
| the development of genetic resistance to myxomatosis in wild rabbits in britain. | the presence of genetic resistance to myxomatosis in a sample of wild rabbits from one area in england was reported in 1977. rabbits from three other areas in great britain have been tested subsequently, and all cases showed similar resistance to a moderately virulent strain of myxoma virus. rabbits from one area also showed a significant degree of resistance to a fully virulent strain of virus. it is concluded that genetic resistance to myxomatosis is widespread in wild rabbit populations in br ... | 1984 | 6736637 |
| coevolution of hosts and parasites. | | 1982 | 6755367 |
| distamycin a, a new antiviral antibiotic. | | 1965 | 4286925 |
| specific secretion of polypeptides from cells infected with myxoma virus. | the polypeptides secreted from cells infected with myxoma virus have been studied. three virus-induced polypeptides were detected. one major and one minor polypeptide were synthesized and secreted in the absence of virus dna synthesis; one minor polypeptide was not detected in the medium under such conditions. all these polypeptides were glycosylated and one was sulphated. two precipitin lines were seen in ouchterlony tests examining medium from infected rabbit cells and using serum from rabbits ... | 1982 | 7119749 |
| genetic factors in resistance against virus infections. | | 1965 | 4286847 |
| studies on the poxvirus cotia. | the poxvirus cotia was studied by electron microscopy and by serological and biochemical analyses. thin-sectioned preparations of infected vero cells indicated that cotia virus morphogenesis was similar to other mammalian poxviruses; unique filamentous structures and inclusion matrices were apparent in the cytoplasm. complement fixation tests that included purified cotia virions showed a reciprocal cross-reaction with rabbit myxoma virus and no cross-reaction with vaccinia virus. serological res ... | 1980 | 7365467 |
| cell surface antigens induced by poxviruses. i. effects of antimetabolites on cell surface antigens. | | 1971 | 4109993 |
| virus-vectored immunocontraception for control of wild rabbits: identification of target antigens and construction of recombinant viruses. | the need to control animal populations arises in many situations in the world from a variety of motives. present control strategies are almost universally based on lethal procedures. increasingly, there is dissatisfaction with such approaches from many different perspectives. in response to these concerns, the concept of controlling populations of pest species through control of their fertility has been mooted. successful examples of this approach exist in cases of small, discrete pest populatio ... | 1994 | 7569043 |
| in vivo interference between pathogenic and non-pathogenic viruses. | the interference among viruses is a well-documented biological phenomenon, both in animals and tissue culture systems. in two of our previous in vivo experiments and in four independent animal experiments, which are described in this presentation, interferences were successfully used to influence the outcomes of viral diseases by using non-pathogenic viruses. in this study, four pathogenic viruses were studied in their natural hosts, and against these viruses, in different combinations, 15 non-p ... | 1985 | 3868686 |
| species specificity of ectromelia virus and vaccinia virus interferon-gamma binding proteins. | interferon-gamma functions within the immune system as a potent anti-viral and immunoregulatory cytokine. in order to successfully replicate within a host cell, poxviruses have evolved a number of strategies to counteract the pleiotropic effects of interferon-gamma. in particular, the leporipoxvirus myxoma virus was shown to express an extracellular soluble interferon-gamma receptor homolog, denoted m-t7, which is capable of inhibiting the anti-viral activities of rabbit interferon-gamma (c. upt ... | 1995 | 7747448 |
| changes in the virulence of myxoma virus strains in britain. | national surveys of the virulence of field strains of myxoma virus were carried out in 1975 (128 virus strains) and in 1981 (123 strains), using the virulence testing method employed in a similar survey in 1962. results showed that the virulence of field strains had increased between 1962 and 1975, and again between 1975 and 1981. the increases in virulence are thought to be a result of the development of resistance to myxomatosis in wild rabbit populations. the effects of the changes in virulen ... | 1987 | 3556434 |
| myxoma virus and shope fibroma virus encode dual-specificity tyrosine/serine phosphatases which are essential for virus viability. | sequence analysis of the genomes of the leporipoxviruses myxoma virus and shope fibroma virus (sfv) led to the discovery of open reading frames homologous to the vaccinia h1l gene encoding a soluble protein phosphatase with dual tyrosine/serine specificity. these viral phosphatase genes were subsequently localized to the myxoma bamhi-i fragment and the sfv bamhi-m fragment, and the resulting encoded proteins were designated i1l and m1l, respectively. the localization and orientation of the myxom ... | 1995 | 7831813 |
| a model of myxomatosis based on hormonal control of rabbit-flea reproduction. | a two-dimensional first-order nonlinear system of ordinary differential equations with constant coefficients is constructed to model the rabbit/flea dynamics of the european rabbit viral disease known as myxomatosis. it is proved that infected fleas induce stable oscillations of small amplitude for a range of coefficient values when the rothschild coupling coefficient r, which models biochemical control of flea reproduction by the rabbit, attains a critical (hopf) value ro. these oscillations ma ... | 1988 | 3392434 |
| human aids and rabbit myxomatosis. | | 1988 | 3351314 |
| control of rabbit myxomatosis in poland. | the authors present an epizootiological analysis of myxomatosis in poland. the biological, physical and chemical properties of virus strains used for the production and control of 'myxovac m' vaccine are discussed. the long-term stability, safety and efficacy of the vaccine are demonstrated. laboratory experiments were confirmed in large-scale field observations. | 1994 | 7949359 |