| maturation of the adrenal medulla--iv. effects of morphine. | | 1975 | 7 |
| comparison between procaine and isocarboxazid metabolism in vitro by a liver microsomal amidase-esterase. | | 1975 | 8 |
| radiochemical assay of glutathione s-epoxide transferase and its enhancement by phenobarbital in rat liver in vivo. | | 1975 | 9 |
| digitoxin metabolism by rat liver microsomes. | | 1975 | 10 |
| the effect of adrenaline and of alpha- and beta-adrenergic blocking agents on atp concentration and on incorporation of 32pi into atp in rat fat cells. | | 1975 | 12 |
| action of propranolol on mitochondrial functions--effects on energized ion fluxes in the presence of valinomycin. | | 1975 | 13 |
| increase in acetyl coa synthetase activity after phenobarbital treatment. | | 1975 | 15 |
| effects of 5,6-dihydroxytryptamine on tyrosine-hydroxylase activity in central catecholaminergic neurons of the rat. | | 1975 | 17 |
| inhibition of aldehyde reductase isoenzymes in human and rat brain. | | 1975 | 18 |
| antidepressant drugs affect dopamine uptake. | | 1975 | 19 |
| demonstration of tumor inhibiting properties of a strongly immunostimulating low-molecular weight substance. comparative studies with ifosfamide on the immuno-labile ds carcinosarcoma. stimulation of the autoimmune activity for approx. 20 days by ba 1, a n-(2-cyanoethylene)-urea. novel prophylactic possibilities. | a report is given on the recent discovery of outstanding immunological properties in ba 1 n-(2-cyanoethylene)-urea having a (low) molecular mass m = 111.104. experiments in 214 ds carcinosarcoma bearing wistar rats have shown that ba 1, at a dosage of only about 12 percent ld50 (150 mg kg) and negligible lethality (1.7 percent), results in a recovery rate of 40 percent without hyperglycemia and, in one test, of 80 percent with hyperglycemia. under otherwise unchanged conditions the reference sub ... | 1975 | 22 |
| influence of a new virostatic compound on the induction of enzymes in rat liver. | the virostatic compound n,n-diethyl-4-2-(2-oxo-3-tetradecyl-1-imidazolidinyl)-ethyl-1-piperazinecarboxamide-hydrochloride (5531) was analyzed as to its effect on the induction of tryptophan-pyrrolase and tyrosineaminotransferase in rat liver. 1. the basic activity of the enzymes was not influenced by the substance either in normal or in adrenalectomized animals. 2. the induction of the enzymes by cortisone increased in the presence of the compound whereas the substrate induction remained unchang ... | 1975 | 24 |
| pharmacological properties of new neuroleptic compounds. | rmi 61 140, rmi 61 144 and rmi 61 280 are newly synthetized n-8-r-dibenzo(b,f)oxepin-10-yl-n'-methyl-piperazine-maleates which show interesting psychopharmacologic effects. this work contains the results of a study performed with these three compounds, in order to demonstrate their neuropsycholeptic activity in comparison with chloropromazine (cpz) and chlordiazepoxide (cpd). the inhibition of motility observed in mice shows that the compounds reduce the normal spontaneous motility as well as th ... | 1975 | 25 |
| phospholipase a2 as a probe of phospholipid distribution in erythrocyte membranes. factors influencing the apparent specificity of the reaction. | the action of snake venom phospholipases a2 in intact human erythrocytes was investigated in detail. the basis phospholipase from agkistrodon halys blomhifii was found to induce both hydrolysis of membrane phospholipids and total cell hemolysis under certain experimental conditions. the hydrolytic action of the basic enzyme was found to consist of two sequential events: (a) hydrolysis of 70% of the total cell ph osphatidylcholine without any evident hemolysis; and (b) complete hydrolysis of the ... | 1975 | 54 |
| partial purification and properties of microsomal phosphatidate phosphohydrolase from rat liver. | microsomal phosphatidate phosphohydrolase (phosphatidate phosphatase ec 3.1.3.4) was solubilized and fractionated to yield at least two distinct enzymatically active fractions. one, denoted fa, was non-specific, had a relatively high km for phosphatidic acid and was insensitive to inhibition by diacylglycerol. the second fraction, fb, was specific for phosphatidates, had a low km, and was inhibited, non-competitively, by diacylglycerol. fa exhibited a sigmoid substrate-activity curve. the isolat ... | 1975 | 64 |
| bile acids. xlvii. 12alpha-hydroxylation of precursors of allo bile acids by rabbit liver microsomes. | rabbit liver microsomal preparations fortified with 0.1 mm nadph effectively promote hydroxylation of 3beta-3h- or 24-14callochenodeoxycholic acid or 5alpha,6alpha-3h25alpha-cholestane-3alpha,7alpha-diol to their respective 12alpha-hydroxyl derivatives in yields of about 25 or 65% in 60 min. minor amounts of other products are formed from the diol. the requirements for activity of rabbit liver microsomal 12alpha-hydroxylase resemble those of rat liver microsomes. of a number of enzyme inhibitors ... | 1975 | 65 |
| partial purification and properties of a phenobarbital-induced aldehyde dehydrogenase of rat liver. | properties of the phenobarbital induced cytoplasmic aldehyde dehydrogenase (ec 1.2.1.3) have been studied in rat liver. 7-12-fold higher levels were seen in the cytoplasmic activities after phenobarbital treatment in reactor compared to non-reactor animals with high concentrations of acetaldehyde (18 mm) and propionaldehyde (9 mm). no difference was found with 0.12 mm acetaldehyde, 2 mm glycolaldehyde, 6 mm formaldehyde or 0.5 mm betaine aldehyde. the reactor group also had slightly higher activ ... | 1975 | 66 |
| characteristics of the dephosphorylated form of phosphorylase purified from rat liver and measurement of its activity in crude liver preparations. | the phosphorylated form of liver glycogen phosphorylase (alpha-1,4-glucan : orthophosphate alpha-glucosyl-transferase, ec 2.4.1.1) (phosphorylase a) is active and easily measured while the dephosphorylated form (phosphorylase b), in contrast to the muscle enzyme, has been reported to be essentially inactive even in the presence of amp. we have purified both forms of phosphorylase from rat liver and studied the characteristics of each. phosphorylase b activity can be measured with our assay condi ... | 1975 | 75 |
| studies on rat renal cortical cell kallikrein. i. separation and measurement. | a technique has been developed to separate and measure kallikrein in a heterogeneous population of rat renal cortical cells in suspension. after rat kidneys were perfused in situ in anaesthetized rats, viable, counted cortical cell suspensions were obtained. cells were suspended in a sucrose/tris buffer containing 0.5% deoxycholate, homogenized, centrifuged, dialyzed, and gel filtered on sephadex g-25. column chromatography on deae-cellulose resulted in a single peak of esterase activity between ... | 1975 | 78 |
| effects of membrane ribonuclease and 3'-nucleotidase on the digestion of polyuridylic acid by rat liver plasma membrane. | 1. fragments of isolated rat liver plasma membrane possess a ribonuclease activity which at ph 7.8 in the presence of 10 mm edta can digest polyuridylic acid (poly(u)) and polycytidylic acid (poly(c)) but not polyadenylic acid (poly(a)) and polyguanylic acid (poly(g)). under these conditions, the membrane preparation does not degrade native or denatured dna. 2. the products of the reaction with poly(u) (10 mm edta present) can be separated on deae-sephadex into oligonucleotides of increasing cha ... | 1975 | 89 |
| level of nicotinamide coenzymes in the liver and myocardium of rats poisoned with dichlorethane. | experiments were conducted on male rats. a study was made of the content of nicotinamide coenzymes in the liver and myocardium 24 hours after the administration of 0.5 ml of dichloroethane into the stomach. in parallel with disturbance of the morphological structure of the liver and of the myocardium, increase in the activity of alanine and aspargic aminotranspherases in the blood serum, dichloroethane reduced the content of nicotinamide coenzymes and deranged the ratio of their oxidized and red ... | 1975 | 104 |
| effect of carbidine on conditioned defense reflexes. | chronic experiments were conducted on rats and rabbits; a study was made of the effect of carbidine on the conditioned defence reflexes in stimulation of the mesencephalic part of the reticular formation. carbidine prevented the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of the reticular formation. this pointed to its depressive influence on the mentioned structures, and was confirmed by experiments on rabbits in recording changes in biocurr ... | 1975 | 105 |
| level of nicotinamide coenzymes in the myocardium of rats during the effects of methylxanthines (theophylline, theobromine, caffeine) and catecholamines. | it was shown in acute experiments on rats that one hour after an intraperitoneal injection of theophylline (50 mg/kg) there was a decrease in the nad + nadp content by 19.4%, a tendency to a fall of nad.h2 + nadp.h2 was expressed, and the total nicotinamide coferment level was reduced. a tendency to decrease nad + nadp and the total pyridine nucleotide level was seen after caffeine administration. the action of catecholamines and methylxanthines was compared. theobromine produced no significant ... | 1975 | 106 |
| proceedings: central hypertensive action of histamine in rats. | | 1975 | 114 |
| proceedings: response of identified ventromedial hypothalamic nucleus neurons to putative neurotransmitters applied by microiontophoresis. | | 1975 | 115 |
| proceedings: is atp an inhibitory neurotransmitter in the rat stomach. | | 1975 | 117 |
| proceedings: the role of dopamine in rotational behaviour produced by unilateral lesions of the locus coeruleus. | | 1975 | 119 |
| proceedings: do anti-psychotic drugs act by dopamine receptor blockade in the nucleus accumbens. | | 1975 | 120 |
| uptake of radiolabeled glucose analogues by organotypic pia arachnoid cultures. | | 1975 | 130 |
| alpha-naphthoflavone activation of 6-hydroxymethylbenzo(alpha)pyrene synthetase. | alpha-naphthoflavone activates the aryl hydroxymethyl synthetase of both the microsomal membrane-bound and soluble enzymes of rat liver and rat lung. the enzyme catalyzes the hydroxymethylation of benzo(alpha)pyrene to the 6-hydroxymethyl derivative. | 1975 | 143 |
| the effects of the continuous administration of n,n-dimethyl-4-phenylazoaniline (dab) on the activities and the inducibilities of some drug-metabolizing enzymes in rat liver. | (1) the effect of feeding a relatively low-protein diet containing 0.06% dab for 29 weeks on the activity of dab-azoreductase, nitroreductase (p-nitrobenzoic acid), n-oxidase (n,n-dimethylaniline), n-demethylase (dab), cytochrome p-450, nadph-cytochrome c reductase, beta-glucuronidase and arylsulphatase a were studied. rapid decreases occurred in the activities of the first six enzymes, reaching minimal values at between 4 and 8 weeks. activities then increased in all cases to control or nearly ... | 1975 | 148 |
| some characteristics of two azoreductase systems in rat liver. relevance to the activity of 2-4'-di(2"-bromopropyl)-aminophenylazobenzoic acid (cb10-252), a compound possessing latent cytotoxic activity. | the system involved in the reduction of 2-4'-di(2''-bromopropyl) aminophenylazolbenzoic acid (cb10-252), an agent designed for treating primary liver cell cancer, has been demonstrated to be localised mainly in the 108 000 x g supernatant fraction of rat liver homogenate. it is also present in other organs particularly in the spleen. dab-azoreductase as shown previously is present almost entirely in the microsomal fraction and is found in high concentration only in liver. the ph maximum for cb10 ... | 1975 | 149 |
| spontaneous mortality and vascular lesions in 3 rat strains with different blood pressure levels. | we have observed a high and significant mortality in spontaneously hypertensive rats compared to normotensive and hypotensive controls, in the fifth generation. the hypertensive rats exhibited a high frequency of cerebral haemorrhage and periarteritis nodosa. | 1975 | 152 |
| effect of coronary blood flow on glycolytic flux and intracellular ph in isolated rat hearts. | the rate of coronary blood flow was varied in isolated working rat heart preparations to determine its influence on the rate of glocose utilization, tissue high-energy phosphates, and intracellular ph. a 60% reduction in coronary blood flow resulted in a 30% reduction in oxygen consumption, an accelerated rate of glusoe utilization, lower tissue levels of high-energy phosphate, and higher tissue levels of lactate and h+. ventricular performance deteriorated as reflected by a decrease in heart ra ... | 1975 | 156 |
| mechanisms of glycolytic inhibition in ischemic rat hearts. | the mechanisms of glycolytic inhibition in ischemic myocardium were investigated in the isolated, perfused rat heart. glycolysis was inhibited at the level of glyceraldehyde-3-phosphate dehydrogenase. the major factors that accounted for the glycolytic inhibition in the ischemic heart compared with the anoxic heart appeared to be higher tissue levels of lactate and h+ in the ischemic tissue. increased extracellular ph inhibited glycolysis in anoxic and hypoxic hearts much more readily than it di ... | 1975 | 157 |
| a comparison of intestinal amino acid absorption in various avian and mammalian species. | | 1976 | 178 |
| the relative importance of monoamine oxidase and catechol-o-methyl transferase on the physiologic response to administered norepinephrine in the turkey. | | 1975 | 200 |
| evidence of a gastrin-like substance in rhinobatus productus. | | 1975 | 206 |
| effects of maleate on renal reabsorption of bicarbonate. | | 1975 | 211 |
| bicarbonate inhibition of rat kidney aconitate hydratase isoenzymes. | | 1975 | 212 |
| metabolic studies in experimental renal dysfunction resulting from maleate administration. | | 1975 | 213 |
| the metabolic fate of securinine. | | 1975 | 219 |
| liver microsomal beta-glucuronidase and udp-glucuronyltransferase. | both udp-glucuronyltransferase (gt) and beta-glucuronidase (betag) were assayed in untreated liver microsomes. optimum assay conditions were established with rat liver microsomes using p-nitrophenol (pnp) and its glucuronide (pnpga) at the ph optima of gt (7.5) and betag (4.5). the activities of the two enzymes were compared using microsomes from rats, mice, pigs, cattle and horses, with pnp, pnpga, and phenolphthalein as substrate, in the presence of various cofactors and inhibitors at ph 7.5 a ... | 1975 | 230 |
| hydrogen ion changes and contractile behavior in the perfused rat heart. | the effect of acid-base alterations was analyzed using isolated rat hearts perfused at constant coronary perfusion pressure, and stimulated to contract at constant rat. the amount of shortening in the major axis and its derivative were measured to assess myocardial contractility. both the 'respiratory' and 'metabolic' alterations affected the contractile behavior to the same extent. in the physiological range studied by us, acidosis depresses and alkalosis increases myocardial contraction. howev ... | 1975 | 240 |
| mechanisms of the thermogenic action of noradrenaline during adaptation to cold. | in white rats both adapted and unadapted to cold, the rq dynamics during cold exposure, noradrenaline and ganglion blocking agent administration, were studied. the adapted animals' rq in thermoneutral conditions was shown to be a little higher than in the control rats; 0.5 mg/kg noradrenaline injections induced a clear rq decrease in the former and did not influence the latters' rq. cold exposure was followed by a rq decrease in both. ganglion blocking agent administration decreased the rq in th ... | 1975 | 257 |
| the protective effects of cephaloridine on rat kidney lysosomes in vitro. | | 1975 | 265 |
| biphasic (ulcer-forming and ulcer-preventing) effect of adrenaline in rats. | adrenaline-induced gastric ulceration was studied in rats. adrenaline in high doses caused gastric ulcer, which was completely blocked by pretreatment with alpha-blockers (phenoxybenzamine, dibenamine), but not by pretreatment with propranolol or atropine, nor by vagotomy, hypophysectomy or adrenalectomy. after successive administration of adrenaline, once daily for 7 days, however, no gastric ulcer was observed. recovery from the ulcerogenic action of adrenaline was seen after 4 weeks withdrawa ... | 1975 | 278 |
| comparison of drug effects on the isolated rat colon and duodenum. | adrenaline and isoproterenol elicited nearly maximal relaxation of the colon even in small doses, whereas increase in the doses caused greater relaxation in the duodenum. in the colon, these drugs prevented, to a great extent the contraction induced by acetylcholine (ach) and serotonin but in the duodenum were totally ineffective. dibenamine and propranolol reduced adrenaline- and isoproterenol-induced relaxation in the duodenum, though propranolol decreased the relaxation caused by isoprotereno ... | 1975 | 279 |
| the effect of ctab, a cationic surfactant, on the absorption rate of 14ctripalmitate from a test meal in the rat. | | 1975 | 290 |
| schiff-type dyes in the cytochemical staining of dna. | | 1975 | 326 |
| response of alanine, tyrosine & leucine aminotransferases to dietary pyridoxine & protein in rat tissues. | | 1975 | 327 |
| in vitro antagonism of the mediators of allergy by a benzopyrano-benzopyran carboxylic acid pr-d-92-ea. | pr-d-92-ea was tested on isolated guinea pig ileum and rat stomach strips for activity against mediators probably released after allergen antibody union. it antagonized the response produced by histamine, bradykinin, serotonin, prostaglandin e2, prostaglandin f2alpha and slow-reacting substance of anaphylaxis (srs-a). the concentrations which blocked 50% of the response were 150, 145, 92, 70, 47, and 32 mug/ml, respectively. this compound may be useful in the treatment of allergic conditions. | 1975 | 336 |
| the influence of injection route and ph value on the activity ratio of yttrium-90 to strontium-90 in the rat skeleton after 90sr incorporation. | | 1975 | 347 |
| phospholipase d activity of gram-negative bacteria. | a phospholipase hydrolyzing cardiolipin to phosphatidic acid and phosphatidyl glycerol was characterized in gram-negative bacteria but was absent in preparations of gram-positive bacteria, saccharomyces cerevisiae, and rat liver mitochondria. in cell-free extracts of escherichia coli, salmonella typhimurium, proteus vulgaris, and pseudomonase aeruginosa, this cardiolipin-hydrolyzing enzyme had similar ph and mg2+ requirements and displayed a specificity which excluded phosphatidyl glycerol and p ... | 1975 | 360 |
| rapid radioimmunoassay for guanosine 3',5'-cyclic monophosphate using tritiated ligand. | a radioimmunoassay procedure for guanosine 3',5'-cyclic monophosphate (cgmp) is described. the procedure is based on competitive binding between 3hcgmp and non-radioactive cgmp, with separation of bound and unbound cgmp by millipore filtration. the binding reaction showed very high specificity to cgmp, had a broad ph optimum, and reached equilibrium within a short time. a simple procedure for the pruification of assay samples using dowex ag 50w-x2 resin is also described. cgmp contents in urine ... | 1975 | 374 |
| the effect of tryptophan administration on fatty acid synthesis in the livers of rats under various nutritional conditions. | 1. tryptophan was administered to rats under various nutritional conditions: fasted for 24 hr, fasted and refed with glucose or corn-oil, fasted and administered glycerol intramuscularly, and nonfasted. 2. the changes in the contents of glycolytic intermediates in the livers indicated that the phosphoenolpyruvate carboxykinase ec 4.1.1.32 reaction is inhibited by tryptophan administration in all groups of rats. the inversely related changes in the contents of malate and phosphoenolpyruvate were ... | 1975 | 375 |
| studies on cathepsins of rat liver lysosomes. ii. comparative studies on multiple forms of cathepsin a. | the multiple forms of cathepsin a (ai, aii, and aiii) purified from the lysosome fraction of rat liver by sephadex g-200 and deae-sephadex chromatographies were studied comparatively. forms ai, aii and aiii were stable between ph 3.0 and 5.5, and had ph optima for cbz-glu-phe at 5.6, 5.8, and 5.9, respectively. these activities were rapidly lost on heating above 60 degrees. their isoelectric points were at 4.7, 4.8, and 4.9, and the michaelis constants for cbz-glu-phe were calculated as 10, 6.6, ... | 1975 | 377 |
| the nsila-s receptor in liver plasma membranes. characterization and comparison with the insulin receptor. | nsila-s (nonsuppressible insulin-like activity, soluble in acid ethanol) is a serum peptide that has insulin-like and growth-promoting activities. we have demonstrated previously that liver plasma membranes possess separate receptors for nsila-s and insulin and have characterized the insulin receptor in detail. in the present study we have characterized the properties and specificity of the nsila-s receptor and compared them to those of the insulin receptor in the same tissue. both 125i-nsila-s ... | 1975 | 391 |
| structure, composition, physical properties, and turnover of proliferated peroxisomes. a study of the trophic effects of su-13437 on rat liver. | peroxisome proliferation has been induced with 2-methyl-2-(p-1,2,3,4-tetrahydro-1-naphthyl-phenoxy)-propionic acid (su-13437). dna, protein, cytochrome oxidase, glucose-6-phosphatase, and acid phosphatase concentrations remain almost constant. peroxisomal enzyme activities change to approximately 165%, 50%, 30%, and 0% of the controls for catalase, urate oxidase, l-alpha-hydroxy acid oxidase, and d-amino acid oxidase, respectively. for catalase the change results from a decrease in particle-boun ... | 1975 | 406 |
| serum-free growth of htc cells containing glucocorticoid- and insulin-inducible tyrosine aminotransferase and cytoplasmic glucocorticoid receptors. | htc cells have been made to grow in chemically defined medium without any macromolecular supplements whatsoever. initial estimates of their relative amino acid requirements have been made. the cells grown in the defined medium retain many of the differentiated features which have been the focus of investigation in their serum-grown counterparts. thus, the cells in defined medium contain cytoplasmic glucocorticoid receptors and have tyrosine aminotransferase which can be induced by glucocorticoid ... | 1975 | 411 |
| dependence on dose of the acute effects of ethanol on liver metabolism in vivo. | the dose dependence of the acute effects of ethanol upon liver intermediary metabolism in vivo has been demonstrated in rats. ethanol was given i.p. in doses of 0.69, 1.7, and 3.0 g/kg in equal volumes (20 ml/kg). the liver was freeze-clamped 120 min after injection, and multiple metabolites were measured in the perchloric acid extract of the tissue. each group showed a significantly different pattern of metabolites, redox states, and phosphorylation potentials although the rate of ethanol disap ... | 1975 | 422 |
| evidence from rats that morphine tolerance is a learned response. | it is proposed that the direct analgesic effect of morphine becomes attenuated over the course of successive administrations of the narcotic by a conditioned, compensatory, hyperalgesic response elicited by the administration procedure, the net result being analgesic tolerance. using the "hot plate" analgesia assessment situation with rats, this conditioning view of tolerance is supported by several findings: (a) it is necessary to have reliable environmental cues predicting the systemic effects ... | 1975 | 425 |
| a field survey on home environmental sanitation in two districts of kaohsiung city, taiwan. | | 1975 | 456 |
| ionic properties of the acetylcholine receptor in cultured rat myotubes. | the acetylcholine reversal potential (er) of cultured rat myotubes is -3mv. when activated, the receptor is permeable to k+ and na+, but not to cl- ions. measurement of er in tris+-substituted, na-free medium also indicated a permeability to tris+ ions. unlike adult frog muscle the magnitude of er was insensitive to change in external ca++ (up to 30 mm) or to changes in external ph (between 6.4 and 8.9). the equivalent circuit equation describing the electrical circuit composed of two parallel i ... | 1975 | 460 |
| cerebral aromatic aminotransferase. | | 1975 | 469 |
| stearyl coenzyme a desaturase activities in rat brain microsomes. | | 1975 | 470 |
| fatty acid and ketone body metabolism in the rat: response to diet and exercise. | this study was designed to measure the response of key enzymes of ketone body metabolism in heart, skeletal muscle, and liver to diet and exercise, two conditions known to influence ketone body utilization. a 3 (diet: control, high fat, or high carbohydrate) x 2 (kill condition: rested or exhausted) x 2 (training: trained or untrained) factorial design was used to estimate main experimental effects as well as identify significant interactions of the variables. physical training (treadmill runnin ... | 1975 | 475 |
| studies on the mechanism of depletion of striatal dopamine by alpha-methyl-m-tyrosine. | these experiments were designed to study the mechanism of depletion of dopamine (da) in the striatum produced by alpha-methyl-m-tyrosine (alpha-mmt). alpha-methyl-m-tyramine (alpha-mmta), the metabolite of alpha-mmt, appears to be the active da-depleting agent, since the administration of a decarboxylase inhibitor before alpha-mmt markedly reduced both the formation of alpha-mmta and the depletion of da. after injection of alpha-mmt (100 mg/kg i.p.), the striatal concentration of homovanillic ac ... | 1975 | 490 |
| n-isopropyl derivatives of dopamine and 5,6-dihydroxy-2-aminotetralin. | secondary and tertiary amino homologs of the title compounds have been prepared, bearing an n-isopropyl group. in peripheral evaluation, certain members of the series exhibited beta-adrenergic agonist effects of lower activity than isoproterenol. n-methyl-n-isopropyl-5,6-dihydroxytetralin exhibited marked properties consistent with its being an alpha agonist, and it is concluded that introduction of considerable bulk about the nitrogen of a catecholamine does not a priori destroy alpha-agonist e ... | 1975 | 497 |
| postnatal development of testicular capillaries and the effect of experimental cryptorchid on capillaries in rats. | | 1975 | 532 |
| multiple cyclic nucleotide phosphodiesterases in rat kidney. | using deae-cellulose chromatography and agarose gel filtration we have partially purified a low km cyclic adenosine monophosphate (amp) phosphodiesterase from the 100,000 x g supernatant of rat kidneys. the characteristics of this enzyme included a km of approximately 4 mum a ph optimum of around 8.0 and a requirement for magnesium. this preparation should be suitable for investigation of possible effects of hormones, drugs and cellular constituents on the cyclic amp pathway through any direct e ... | 1975 | 537 |
| the effects of drinking on offspring: an historical survey of the american and british literature. | current research on the effects on offspring of drinking during pregnancy has revived interest in an extremely old topic. observations made during england's gin epidemic (1720-1750) were followed by warnings of 19th-century medical writers that parental drinking could damage the fetus. many concurring studies were reported in the medical literature from 1865 to 1920. research interest declined during prohibition, and authorities later discounted the previous work. recently a relationship between ... | 1975 | 545 |
| interactions of age, sex and long-term alcohol intake in selectively bred strains of rats. | the alcohol consumption by five genotypes of rats was studied in two experiments. alcohol intake was age-dependent in rats bred for high emotional reactivity and avoidance conditionability. differences in consumption by sex appeared to be primarily due to differences in body weight. | 1975 | 550 |
| calcium activation of brain tryptophan hydroxylase. | | 1975 | 566 |
| acute and chronic effects of nicotine on synthesis and storage of catecholamines in the rat adrenal medulla. | | 1975 | 567 |
| catechol-o-methyltransferase from rat liver: two forms having different meta:para methylation ratios. | | 1975 | 570 |
| adenosine as a putative transmitter in the cerebral cortex. studies with potentiators and antagonists. | | 1975 | 572 |
| kinetic characterization of rat serum dopamine-beta-hydroxylase using a simplified radioenzymatic assay. | | 1975 | 573 |
| phosphate transport in rat liver mitochondria. kinetics, inhibitor sensitivity, energy requirements, and labeled components. | experiments were carried out to define the kinetic parameters of the major phosphate transport processes of rat liver mitochondria, and to obtain information about the molecular properties of these systems. | 1975 | 609 |
| l-tyrosine: 2-oxoglutarate aminotransferase induction by hydrocortisone in the thymus of the white rat. | hydrocortisone hemisuccinate within 4 hours after in vivo administration produced an increase in precursor incoporation into rat thymus rna and proteins in the whole animal. from these results, together with information obtained from measurements of the tyrosine aminotransferase activity and the action of mitomycin c administered one hour before the injection of hydrocortisone, it can be concluded that the increase in tissue level of the enzyme, consequent to hydrocortisone treatment, results fr ... | 1975 | 610 |
| selective release of newly synthesised and newly captured gaba from synaptosomes by potassium depolarisation. | | 1975 | 618 |
| effect of minor tranquillisers on hippocampal theta rhythm mimicked by depletion of forebrain noradrenaline. | | 1975 | 619 |
| direct identification and characterisation of beta-adrenergic receptors in rat brain. | | 1975 | 620 |
| prolonged activation of tyrosine hydroxylase in noradrenergic neurones of rat brain by cholinergic stimulation. | | 1975 | 621 |
| induction of tyrosine aminotransferase by insulin not mediated by cyclic gmp. | | 1975 | 625 |
| investigation into some imidazoline compounds, with respect to peripheral alpha-adrenoceptor stimulation and depression of cardiovascular centers. | peripheral alpha-adrenoceptor stimulation was tested by means of hypertensive effects of the drugs following i.v. injection in spinal rats. naphazoline (np), oxymetazoline (om), st 91-2-(2,6-diethylphenylimino)-2-imidazolidine--and st 1697--2-(2-ethyl, 6-methylphenylimino)-2-imidazolidine--were 3 to 5 times more potent in tthis respect thatn clonidine (clon) whereas st 363--2-(2,4-dichlorophenylimino)-2-imidazolidine--and xylazine (xy) exerted only approx. 1/20 the effect of that of clonidine. s ... | 1975 | 628 |
| the regulation of striatal tyrosine hydroxylase. effects of gamma hydroxybutric acid and healperidol. | gamma-hydroxybutyric acid (ghba) in doses that increased the striatal dopamine (da) content of rat brain failed to increase the affinity of striatal tyrosine hydroxylase (th) for its pterdine cofactor or to change the sensitivity of the enzyme to the inhibition by da. haloperidol (1 mg/kg) decreased the apparent km of striatal th for the pteridine cofactor. however, when ghba was injected before haloperidol it prevented the decrease in the apparent kn of th, in a dose related manner. in vitro gh ... | 1975 | 629 |
| a study of the central effects of sympathomimetic drugs: eeg and behavioural investigations on clonidine and naphazoline. | | 1975 | 637 |
| influence of desmethylimipramine on some neurochemical alterations during experimental hypothyroidism. | | 1975 | 638 |
| identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of trypanosoma brucei. | soluble glycoproteins have been purified from a series of clones of trypanosoma brucei 427. each clone yielded a characteristic predominant glycoprotein which induced clone-specific immunity to trypanosome infection in mice. these glycoproteins were shown by specific labelling and enzyme digestion of cells to be the major components of the trypanosome surface coat. each glycoprotein consisted of a single polypeptide chain having an apparent molecular weight of 65 000 (as measured by sds-polyacry ... | 1975 | 645 |
| the relation between myosin adenosinetriphosphatase activity and inactivation of myosin under alkaline conditions of heart muscles in mammals of different size. | atpase activity of myosin in the heart muscle of the mouse, rat, guinea-pig, rabbit and pig was studied at neutral ph and under mild alkaline conditions. at neutral ph the atpase activity of myosin is inversely related to body size of the animal species. the decrease of atpase activity of myosin after alkaline preincubation depends on the degree of atpase activity of intact myosin, i.e. myosin from the heart of the mouse exhibits high atpase activity ae same relationship was found, when comparin ... | 1975 | 651 |
| presence of norepinephrine and related enzymes in isolated brain microvessels. | norepinephrine and the enzymes involved in its synthesis and degradation were found to be associated with isolated brain microvessels. the significance of these results are discussed with respect to adrenergic innervation of the cerebral microvessels and thereby neural regulation of the cerebral microcirculation. | 1975 | 678 |
| structure-activity relationship of phenoxyalkanolamine derivatives with selective beta 1-receptor blocking action. | | 1975 | 687 |
| the pharmacology of (+/-)-1-(4-cyclohexylureido-phenoxy)-2-hydroxy-3-tert-butylaminopropane (talinolol, cordanum, 02-115). | | 1975 | 688 |
| the effects of 1-(4-cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane (talinolol, cordanum, 02-115), practolol and propranolol on the lipid content of the rat serum. | | 1975 | 690 |
| study on the chronic toxicity of 1-(4-cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane(talinolol, cordanum, 02-115) in the rat and the beagle. | | 1975 | 691 |
| teratological study of talinolol (cordanum, 02-115). | | 1975 | 692 |
| the pharmacokinetics of 1-(4-cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane (talinolol, cordanum, 02-115) 2. excretion, blood level and distribution of the 14c-labeled compound in the rat. | | 1975 | 695 |
| some psysicochemical properties of mitochondrial and cell sap alanine aminotransferase from the rat cns. | the authors describe different properties of brain mitochondrial and cell sap alanine aminotransferase. they showed that the mitochondrial enzyme was inhibited by maleate, chlorides, acetate and phosphate with a high ionic strength (over 1.8), that its ph optimum lay between 7.5 and 8.5, that it was thermolabile at over 40 degrees c and that it was salted out from solutions with ammonium sulphate at 0.6--0.8 saturation. the activity of the cell sap enzyme was inhibited by phosphate at an ionic s ... | 1975 | 701 |
| drug addiction: i. a theoretical framework for behavior therapy. | | 1975 | 704 |