a new class of genetically transmitted retravirus isolated from mus cervicolor.the cocultivation of spleen cells from the southeast asian mouse, mus cervicolor, with heterologous cell lines has permitted the isolation of a new retravirus (designated m432) that can be transmitted to tissue culture cells of the laboratory mouse, m. musculus. cells infected with m432 contain cytoplasmic type a particles and budding forms with compact,spherical nucleoids; extracellular virions lack surface spikes and have a condensed, central core surrounded by an intermediate line. like other ...197662362
two distinct endogenous type c viruses isolated from the asian rodent mus cervicolor: conservation of virogene sequences in related rodent species.the cocultivation of a lung cell line from the southeast asian mouse mus cervicolor with cells from heterologous species has resulted in the isolation of two new distinct type c viruses. both viruses are endogenous to m. cervicolor and are present in multiple copies in the cellular dna of these mice. one of the viruses, designated m. cervicolor type ci, replicates readily in the sirc rabbit cell line and is antigenically related to the infectious primate type c viruses isolated from a woolly mon ...197766330
a new class of murine retroviruses: immunological and biochemical comparison of novel isolates from mus cervicolor and mus caroli. 197770107
characterization of a new virus from mus cervicolor immunologically related to the mouse mammary tumor virus.a virus, similar to the murine mammary tumor viruses (mumtv) of the laboratory mouse mus musculus, was identified in the milk of m. cervicolor popaeus mice. the virus was morphologically indistinguishable from the type-b mumtv and was thus termed mc-mtv. radioimmunoassays for the 52,000-dalton major envelope glycoprotein and the 28,000-dalton major internal protein of mumtv demonstrated that mc-mtv shared some antigenic determinants with both of these mumtv proteins. this reactivity was clearly ...197882634
radioimmunoassays for the 36,000-dalton glycoprotein of murine mammary tumor viruses demonstrate type, group, and interspecies determinants.mouse mammary tumor viruses (mmtvs) contain distinct membrane glycoproteins of 52,000 daltons (gp52) and 36,000 daltons (gp36). we report here the development of new radioimmunoassays for gp36, using gp36 purified by hydrophobic chromatography and gel filtration. these assays demonstrate that gp36 has both type-specific and group-specific antigenic determinants. the virus-coded nature of these determinants was shown by utilizing different mmtvs grown in the same feline cell line. interspecies d ...197990170
expression of akr murine leukemia virus gp71-like and balb(x) gp-71-like antigens in normal mouse tissues in the absence of overt virus competition radioimmune assays with antisera against akr murine leukemia virus (mulv) gp 71 or antisera against xenotropic virus, and iodinated akr mulv gp71 or balb(x) gp71, antigens serologically indistinguishable from the viral antigens can be detected in tissues of normal mice in the absence of overt virus expression. an antigen serologically indistinguishable from akr mulv gp71 can be readily detected in normal bone marrow cells of the common strains of mice including nih swiss, 129/j, a ...1977195002
nucleotide sequence relationship between intracisternal type a particles of mus musculus and an endogenous retrovirus (m432) of mus cervicolor.intracisternal type a particles are retrovirus-like structures found in embryonic cells and many tumors of mus musculus but having no clear relationship with other retroviruses of this mouse species. we have observed a partial nucleotide sequence homology between the high-molecular-weight (32s and 35s) rna components of intracisternal a-particles from a neuroblastoma cell line and the 70s rna fraction from m432, a type of retrovirus endogenous to the asian mouse mus cervicolor. m432 complementar ...1978212615
genes controlling receptors for ecotropic and xenotropic type c virus in mus cervicolor and mus musculus.gene loci controlling cell surface receptors for murine leukemia virus were studied by using murine x chinese hamster hybrid cells. hybrids which exclusively segregate murine chromosomes were made by fusing mus cervicolor and mus musculus lymphocytes to hamster fibroblasts. sensitivity to moloney murine leukemia virus infecotion and specific binding of the envelope glycoprotein of rauscher murine leukemia virus (gp70) cosegregate and isozyme analysis show an association with chromosome 5 in both ...1979219245
intracisternal a particle-specific dna sequences in mammary tumor cells, hybrids, and cybrids derived from laboratory mice and from feral mice of mus musculus and mus cervicolor. 1979223297
development of interspecific hybrids of mus.artificial insemination has been used to produce interspecific mouse hybrids. mus musculus x mus cervicolor cervicolor hybrids failed to complete more than a few cleavage divisions but both m. musculus x m. dunni and m. musculus x m. caroli hybrids completed preimplantation development. these hybrid embryos are heterozygous for various x-linked enzymes and may provide a useful genetic system for studying x-chromosome inactivation during early development. further development of m. muscuius x m. ...1977591872
sequences associated with intracisternal a particles are reiterated in the mouse genome.using a 3h-cdna for rna sequences specifically associated with murine intracisternal type a particles, we have found multiple copies of this information in high molecular weight nuclear dna from tissues of both mus muscules (balb/c, nih swiss, a/jax and feral) and mus cervicolor. reiteration frequencies varied from 1050-1800 per haploid genome, except that fewer copies (450) were found in balb/3t3 cells. in the series studied, the reiteration frequencies in the dna of a particle-rich tumor cells ...1977597866
genetic variation in mouse apolipoprotein a-iv due to insertion and deletion in a region of tandem repeats.we have detected three unique apolipoprotein a-iv (apoa-iv) charge isoforms in strains of commensal mice. the cdna sequences for one representative of each isoform (mus domestesticus strains c57bl/6j and 129/j and mus castaneus) revealed a polymorphism within a series of four imperfect repeats encoding the sequence glu-gln-ala/val-gln. insertions or deletions of 12 nucleotides within this repetitive region have given rise to three genotypes characterized by three (129), four (c57bl/6), or five ( ...19911648102
mammary tumorigenesis in feral mus cervicolor popaeus.a pedigreed breeding population of feral mus cervicolor popaeus with a high incidence of mammary tumors, arising between 6 and 14 months of age, is described. these mice were chronically infected with a type b retrovirus which is distantly related to the mouse mammary tumor virus (mmtv) of inbred strains of mus musculus. mmtv-induced mammary tumors in inbred mice frequently (80%) contained an insertion of the viral genome into the int-1 or int-2 loci of the tumor cellular genome. these two cellu ...19863009873
serologic variations in kappa light chains of various mus species correlate with differences in gene structure.kappa light chains were investigated in sera of several groups of wild derived mouse strains by radioimmunological analysis using xenogeneic anti-mouse kappa light chain antibodies. although the majority of strains tested expressed serologically indistinguishable kappa chains, several significant exceptions were observed. anti-kappa chain reactivity was not detectable in normal sera of mus caroli and mus cervicolor species using specific antiserum. these strains express a variant of the kappa li ...19863099180
use of monoclonal antibodies to define the diversity of mammary tumor viral gene products in virions and mammary tumors of the genus mus.monoclonal antibodies have been generated against disrupted mammary tumor viruses isolated from mus musculus, mus cervicolor, and mus cookii. monoclonal antibodies directed against the m.w. 36,000 external glycoproteins of these viruses demonstrate the presence of multiple epitopes, i.e., distinct antigenic determinants, within these glycoproteins. these epitopes represent type, group, and interspecies determinants. monoclonal antibodies have also been used to define multiple epitopes on the m.w ...19816163523
genetic relationship between the mus cervicolor m432 retrovirus and the mus musculus intracisternal type a particle.the genetic relationship between the retrovirus-like intracisternal type a particle (iap) from mus musculus and the novel retrovirus (m432) from m. cervicolor has been determined by heteroduplex and restriction endonuclease analyses of molecular clones of the respective genomes. we have found a major homology region (3.7 kilobase pairs) which probably begins near the 3' end of the m432 gag gene, spans the pol gene, and ends in the env gene. a second region (0.6 kilobase pairs) of weak homology w ...19816275124
a unique sequence related to the ecotropic murine leukemia virus is associated with the fv-4 resistance gene.several strains of laboratory and wild-derived mice from japan carry the dominant allele at the fv-4 locus (fv-4r) that is responsible for resistance to infection by exogenous ecotropic murine leukemia virus. we have used blot hybridization with a probe specific for the ecotropic viral envelope to show that a unique envelope-reactive sequence is present in the japanese mouse mus musculus molossinus and in four independently derived partially congeneic strains carrying fv-4r. analysis of 31 backc ...19846322171
immunological relationship between the structural proteins of intracisternal a-particles of mus musculus and the m432 retrovirus of mus cervicolor.a specific immunological relationship has been demonstrated between the main structural protein (p73) of intracisternal a-particles and a major internal protein (p24) of the m432 retrovirus.19807365876
mus cervicolor murine leukemia virus isolate m813 belongs to a unique receptor interference group.murine leukemia virus (mulv) m813 was originally isolated from the southeast asian rodent mus cervicolor. as with the ecotropic mulvs derived from mus musculus, its host range is limited to rodent cells. earlier studies have mapped its receptor to chromosome 2, but it has not been established whether m813 shares a common receptor with any other mulvs. in this study, we have performed interference assays with m813 and viruses from four interference groups of mulv. the infection efficiency of m813 ...200111312319
the mus cervicolor mulv isolate m813 is highly fusogenic and induces a t-cell lymphoma associated with large multinucleated cells.m813 is a type-c murine leukemia virus (mulv) isolated from the asian rodent mus cervicolor. we have recently demonstrated that m813 defines a distinct mulv receptor interference group. here we show that m813 rapidly induces fusion of mulv-expressing fibroblasts from "without," with syncytia being observed within 1 h after exposure to virus. infection of fibroblasts with mulv from all tested receptor-interference groups imparts susceptibility to m813-induced fusion, provided the cells also expre ...200111883004
sodium-dependent myo-inositol transporter 1 is a cellular receptor for mus cervicolor m813 murine leukemia virus.retrovirus infection is initiated by binding of the surface (su) portion of the viral envelope glycoprotein (env) to specific receptors on cells. this binding triggers conformational changes in the transmembrane portion of env, leading to membrane fusion and cell entry, and is thus a major determinant of retrovirus tissue and species tropism. the m813 murine leukemia virus (mulv) is a highly fusogenic gammaretrovirus, isolated from mus cervicolor, whose host range is limited to mouse cells. to d ...200312719585
cell surface receptors for gammaretroviruses.evidence obtained during the last few years has greatly extended our understanding of the cell surface receptors that mediate infections of retroviruses and has provided many surprising insights. in contrast to other cell surface components such as lectins or proteoglycans that influence infections indirectly by enhancing virus adsorption onto specific cells, the true receptors induce conformational changes in the viral envelope glycoproteins that are essential for infection. one surprise is tha ...200312932075
diversity of gastrointestinal helminths among murid rodents from northern and northeastern thailand.the presence of gastrointestinal helminths (gi helminths) was investigated among 725 murid rodents, trapped in various habitats of nan, loei and buri ram provinces, thailand. the study revealed 17 species of rodents infected with 21 species or taxonomic groups of parasites (3 trematodes, 3 cestodes, 14 nematodes and 1 acanthocephalan). the overall prevalence of infection was 57.7% (418/725). of the gastrointestinal (gi) helminths, the dominant parasitic group was members of the family trichostro ...201223082550
mus spicilegus endogenous retrovirus hemv uses murine sodium-dependent myo-inositol transporter 1 as a receptor.we sought to determine the relationship between two recent additions to the murine leukemia virus (mlv) ecotropic subgroup: mus cervicolor isolate m813 and mus spicilegus endogenous retrovirus hemv. though divergent in sequence, the two viruses share an env protein with similarly curtailed vra and vrb regions, and infection by both is restricted to mouse cells. hemv and m813 displayed reciprocal receptor interference, suggesting that they share a receptor. expression of the m813 receptor murine ...201222457525
quinacrine fluorescence of mus cervicolor chromosomes. bright centrometric heterochromatin. 19734131369
temporal, spatial, and ecological modes of evolution of eurasian mus based on mitochondrial and nuclear gene sequences.we sequenced mitochondrial (cytochrome b, 12s rrna) and nuclear (irbp, rag1) genes for 17 species of the old world murine genus mus, drawn primarily from the eurasian subgenus mus. phylogenetic analysis of the newly and previously available sequences support recognition of four subgenera within mus (mus, coelomys, nannomys, and pyromys), with an unresolved basal polytomy. our data further indicate that the subgenus mus contains three distinct 'species groups': (1) a mus booduga species group, al ...200415522792
relatedness of mouse satellite deoxyribonucleic acid to deoxyribonucleic acid of various mus species.mouse (mus musculus musculus) satellite dna is able to reassociate with repeated dna sequences of mus caroli and mus cervicolor, but low thermal stability of the products indicates significant differences between satellite and related dnas of these two mus species. there appear to be several satellite-related populations in m. caroli dna, each of which forms hybrids of low thermal stability with repeated sequences of m. cervicolor dna. dnas from the subspecies mus musculus molossinus and mus mus ...19734519644
mouse haemoglobin beta chains. comparative sequence data on adult major and minor beta chains from two species, mus musculus and mus inbred mus musculus several different beta chains are known. in certain strains two beta chains are produced in unequal amounts by the two closely linked genes of the doublet breeding unit allele hbb(d): betadmaj and betadmin. one strain has a variant doublet allele, hbb(p), which produces a variant minor beta chain, betapmin (the major beta chain, betapmaj, may not differ from betadmaj chain). certain other strains have a singlet allele, hbb(s), that produces only one beta chain, betas. othe ...1976999642
one skull to rule them all? descriptive and comparative anatomy of the masticatory apparatus in five mouse species.murine rodents display a unique cranial morphology and masticatory musculature. yet detailed myological descriptions are scarce, especially considering the great diversity of the subfamily and the use of the house mouse and brown rat as model organisms. the masticatory musculature in these two species has been thoroughly described, which allows comparisons with other wild species. description and comparison of a wide range of species constitutes a necessary step to fully understand how ecologica ...201830117607
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