| defective insulin secretion in the spiny mouse (acomys cahirinus). possible value in the study of the pathophysiology of diabetes. | | 1975 | 169217 |
| a comparison of the structure of hamster pancreatic insulin and insulin extracted from a transplantable hamster islet-cell carcinoma. | insulin has been isolated from pancreases of the syrian hamster and from a transplantable islet-cell tumor of the hamster. acid/ethanol extraction, ether precipitation, ion exchange and gel filtration chromatography gave preparations of suitable purity for structural studies. using trypsin cleavage, automatic edman degradation and manual edman degradation, a complete sequence of the pancreatic insulin b chain was determined. by automatic edman degradation, the amino-terminal 10 residues of the p ... | 1975 | 172143 |
| non shivering thermogenesis and implication of the thyroid in cold labile and cold resistant populations of the golden spiny mouse (acomys russatus). | the golden spiny mouse is dependent on non shivering thermogenesis (n.s.t.) for thermoregulation at cool ambient temperatures. mice from the shores of the dead sea (ein-gedi, eg-mice) lose body heat when exposed to 6 degrees c. their rate of cooling is linearly correlated to the magnitude of n.s.t. this is true for mice acclimated to 28 degrees c, born in the laboratory or freshly captured. mice from the high mountains of south sinai (s-mice) resist cooling under the same conditions and their n. ... | 1978 | 274309 |
| zinc and manganese contents of micro-dissected pancreatic islets of some rodents. a microchemical study in adult and newborn guinea pigs, rats, chinese hamsters and spiny mice. | by a flameless atomic absorption spectrophotometry procedure, using a graphite furnace, it was possible to assay the contents of zinc and managanese in micro-dissected pancreatic islets of several rodents. interest was focused upon the islets of guinea-pigs, due to the fact that guinea-pig insulin lacks a histidine residue in the b10 position of the molecule which normally binds zinc (or other heavy metals) in the hexamer formation, probably involved in the storage of insulin. both the zinc and ... | 1977 | 335757 |
| glucose production by the perfused liver of the spiny mouse (acomys cahirinus): sensitivity to glucagon and insulin. | hepatic glucose production and its responses to glucagon and insulin were studied in perfused livers obtained from spiny mice (acomys cahirinus)--rodents characterized by normoglycemia, decreased glucose tolerance and decreased insulin secretion--and from swiss albino mice. the dose-response characteristics of glucagon-induced hepatic glucose output were similar in spiny and albino mice. however, maximally stimulated glucose production were significantly lower in the spiny mouse. furthermore, th ... | 1979 | 468520 |
| effect of deuterium oxide on the pituitary gonadotrophs of the brown spiny mouse. mus platythrix bennett. | adult individuals of m. platythrix were maintained on 30 per cent d2o by volume in drinking water at varying periods of time. qualitative and quantitative changes in pituitary fsh and lh cells were observed. the former revealed hyperplasia and hypertrophy by 10 days attaining their peak of activity and hyalinization by 20 days. in contrast response in the lh cells was rather slow. they showed a significant increase in number after 30 days and hyalinization by 50 days. fsh cells revealed decline ... | 1979 | 499095 |
| cadmium induced hypertrophy & hyperplasia of pituitary gonadotrophs of the brown spiny mouse mus platythrix (bennett). | | 1979 | 511228 |
| the reproductive tract of the male spiny mouse (acomys cahirinus) and coagulation studies with other species. | the testes of the spiny mice showed asymmetry, the left being significantly heavier than the right (p = 0.025). histological studies indicated that spermatozoa were first present in the testes of animals 35--45 days of age but the maturation of the accessory glands, especially the lateral prostates and coagulating glands, occurred later. the highest fructose concentration in the adult was in the lateral prostates (126.97 +/- 22.23 mg fructose/100 g, n = 5) and coagulating glands (99.38 +/- 17.65 ... | 1979 | 513000 |
| responses of spiny mouse weanlings to conspecific chemical cues. | twenty-five-day-old a. cahirinus pups (weanlings) were tested for their responses to chemical cues produced by various classes of conspecific agemates. in experiment 1, both male and female pups preferred bedding soiled by weanlings of either sex over clean bedding material. subsequent experiments indicate that male but not female weanlings prefer chemical cues emanating from littermates over comparable stimuli from unfamiliar agemates. also, chemicals produced by agemates maintained on the same ... | 1979 | 574652 |
| significance of anomalous thermoregulation in the pre-diabetic spiny mouse (acomys cahirinus): oxygen consumption and temperature regulation. | in keeping with studies of other desert rodents, the potentially diabetic spiny mouse has been demonstrated to have a very low basal metabolic rate, disproportionate to its body weight. the maintenance of a lower body temperature in response to high environmental temperatures and a lack of increase in metabolic rate in response to cooling have also been demonstrated. assessments of "mechanical efficiency" have shown that spiny mice carry a potential selective advantage under fasting conditions. ... | 1977 | 603467 |
| significance of anomalous thermoregulation in the pre-diabetic spiny mouse (acomys cahirinus): cold tolerance: blood glucose and food consumption responses to environmental heat. | decreased cold tolerance, reduced food requirement for body weight maintenance and comparative resistance to the hypoglycaemic effect of fasting in high ambient temperatures have been demonstrated in the spiny mouse. these phenomena could be related to anomalous spiny mouse thermoregulation, a phenomenon which is common in desert rodents and is simulated by mutant and artificially diabetic rodent species. the data can be interpreted as showing evidence for a survival advantage of genotypes with ... | 1977 | 603468 |
| the role of diet in mother-infant reciprocity in the spiny mouse. | one-day-old spiny mouse pups responded preferentially to bedding soiled by lactating conspecifics fed the same diet as their mothers. following this test, pups were fostered onto different-diet females. when retested at 84-96 hr of age, no preferences were shown for bedding soiled by a female fed the biological mother's diet vs bedding of a female fed the different diet. when tested again at 120-132 hr of age, however, the pups preferred the bedding associated with their foster mothers' diet. in ... | 1978 | 658607 |
| animal models of diabetes and obesity, including the pbb/ld mouse. | diabetes mellitus occurs in many animals species. however, only a few have been utilized in systematic studies designed to answer unsolved problems associated with the disorder in man such as molecular basis, pathogenesis of the vascular and neural lesions, and the roles of diet, exercise and obesity. among the animal models available, rodents have been studied most thoroughly for a number of reasons: a) short generation time (sexually mature at about 3 mo of age, gestation time 21 days) and lif ... | 1976 | 770197 |
| changes within vascular bundles of rodent kidneys caused by different diets. | morphological effects caused by two different diets (low protein-high water intake, and high protein-restricted water) on the vascular bundles in the outer medullary zone of the kidney were studied in the laboratory white mouse and in the golden spiny mouse (acomys russatus, muridae). in both rodents, when on a low protein-high water intake diet, considerable interstitial substance was found between the vasa recta of the bundles. no interstitial substance was found in animals on high protein-low ... | 1977 | 880629 |
| maternal pheromone in the spiny mouse (acomys cahirinus). | | 1976 | 944929 |
| thermoregulation and nonshivering thermogenesis as factors limiting distribution of the golden spiny mouse (acomys russatus). | | 1976 | 977311 |
| insulin secretion in the spiny mouse (acomys cahirinus). dose and time kinetic studies with glucose in vivo and in vitro. | plasma insulin responses to the intravenous injection of glucose in the doses of 0.5, 1.5, and 3.0 gm./kg. were compared in spiny mice (acomys cahirinus) and weight-matched swiss albino mice. the mean early (two-minute) plasma insulin response was significantly lower in acomys at all doses of glucose injected; whereas, at later times (5, 15, and 30 minutes), differences in plasma insulin concentrations in the two species of mice were smaller or nonexistent. plasma glucose clearance was significa ... | 1975 | 1104397 |
| ultrastructure of the oocytes of the egyptian sping mouse (acomys cahirinus). | the oocytes of types 2, 3, 4 and 5 follicles from the normal spiny mouse were examined withe the electron microsome. multiple juxtanuclear golgi bodies, mitochondria associated with flattened granular endoplasmic reticulum, and large nucleus are the main features of the type 2 follicle oocyte. the numbers of mitochondria and golgi apparati increase significantly at later stages. small mitochondrial aggregates lacking "intermitochondrial cement" are seen in the ooplasm of types 3, 4 and 5 follicl ... | 1975 | 1171638 |
| size and activity of a cold resistant population of the golden spiny mouse (acomys russatus: muridae). | | 1975 | 1225672 |
| breeding and fertility of the egyptian spiny mouse, acomys cahirinus: effect of different environments. | 2 years experience with acomys in one laboratory confirmed the slow breeding rate found by other workers. on moving the animals to another laboratory there was a 2-5 fold increase in breeding rate. the most likely explanation of this change was the presence of copper in the drinking water at the 1st laboratory, due to the use of copper water pipes. the data relating to maintenance and breeding of acomys for 2 years at the 2nd laboratory were analyzed to provide a more representative picture of t ... | 1976 | 1256010 |
| naturally occurring degrading events in axon terminals of the dentate gyrus and stratum lucidum in the spiny mouse (acomys cahirinus) during maturation, adulthood and aging. | the naturally occurring dynamics of presynaptic axon terminals were investigated in the dentate gyrus and stratum lucidum of the spiny mouse (acomys cahirinus) during maturation, adulthood and aging. a sensitive and selective silver-staining technique was applied to analyze neuronal lysosome accumulation (la), indicating synaptic degradation during development. la was quantified by counting silver grains in the inner third and outer two thirds of the molecular layer, granular layer, and the infr ... | 1992 | 1286623 |
| a relationship between circulating natural glucocorticoids and the mechanical responses of the heart in atricial and precocial rodents. | 1. a comparison was made of the mechanical performance of heart muscle from mouse, an atricial mammal, with corticosterone as glucocorticoid and spiny mouse (acomys cahirinus), a precocial mammal, with cortisol as glucocorticoid. 2. force-frequency responses were negative in mouse and positive in spiny mouse. 3. during recovery, there was a gradual increase and an overshoot in the mouse, while in the spiny mouse there was an initial enhanced response, diminishing gradually with time. 4. high cal ... | 1992 | 1361898 |
| daily rhythms of metabolic rate and body temperature of two murids from extremely different habitats. | daily circadian rhythms of body temperature (tb) and oxygen consumption (vo2) were measured in two murid species, which occupy extremely different habitats in israel. the golden spiny mouse (acomys russatus) is a diurnal murid distributed in arid and hot parts of the great syrio-african rift valley, while the broad-toothed field mouse (apodemus mystacinus) is a nocturnal species that inhabits the mediterranean woodlands. in both species, the daily rhythms of tb and vo2 are entrained by the photo ... | 1992 | 1394605 |
| distance perception in the spiny mouse acomys cahirinus: vertical jumping. | acomys cahirinus, a precocial muroid, that has shown precise jumping in the natural habitat, did not jump from 25 cm in a laboratory situation. to investigate this further, a. cahirinus were observed jumping from platforms at two different heights, onto different sized checkered substrates and from a visual cliff. adult animals discriminated between platforms that were 6.4 cm and 25.4 cm above the substrate and between small and large checkered patterns on the floor. most adult animals and neona ... | 1992 | 1454491 |
| behavior patterns of cold-resistant golden spiny mouse acomys russatus. | nesting behavior and food storage were studied in a cold-resistant (cr) population of the golden spiny mouse, acomys russatus, in southern sinai at an altitude of 1600 m. cr-mice, in contrast to cold-sensitive (cs) ones, built nests in which they stored food. such mice were found to be winter-solitary. these results show that food supply is an essential parameter for the survival of cr-mice during winter. therefore, it is suggested that food supply rather than energy conservation was the main dr ... | 1991 | 1801023 |
| drinking behavior in the spiny mouse (acomys cahirinus) following putative dipsogenic challenges. | male spiny mice (acomys cahirinus) were challenged with several putative dipsogenic stimulus conditions: hypertonic sodium chloride (nacl), 24-h water deprivation, d,l-isoproterenol hcl, angiotensin ii (aii) and polyethylene glycol (peg), or control conditions, in within-subjects designs. water intake and drinking pattern were monitored electronically in the home cage over a 2--6-h test period without food present, during the light portion of the l/d cycle. in addition, hematocrits were measured ... | 1991 | 1871204 |
| differences in beta-adrenergic regulation of cyclic amp formation in cerebral cortical slices of the rat and spiny mouse--acomys cahirinus. | in both the rat and acomys cahirinus the adrenergic cyclic amp generating system in the brain is dependent not only on beta-, but also on alpha-adrenoceptors. the relative role of alpha-adrenoceptors is much greater in the acomys cahirinus. this feature makes the acomys an interesting animal model for investigating the role of alpha-beta-adrenoceptor coupling in generation of cyclic amp and the mechanism of action of antidepressant treatment. | 1990 | 1980732 |
| effect of exogenous insulin on meal patterns and stomach emptying in the spiny mouse. | male adult spiny mice (acomys cahirinus) were acutely challenged with a single dose of regular insulin or saline vehicle sc; either food intake, meal frequency and meal duration, or stomach emptying were then measured. meal frequency, as well as amount eaten, was significantly higher over a 6-hr period following both 10 and 30 u/kg of insulin than following vehicle injection. meal duration remained essentially the same across all conditions. when 30 u/kg of insulin was administered either 15 min ... | 1990 | 2201984 |
| the influence of maternal labels on dietary preferences of spiny mouse weanlings. | to assess the influence of conspecific chemical cues on the development of dietary preferences, spiny mouse (acomys cahirinus) weanling were tested for their responses to food items that were partially eaten (thus, presumably labeled) by various categories of conspecifics. consumption of a highly preferred novel food (fresh carrot) labeled by the pups' parents, or mother alone, was greater than that of a clean sample of the same food. the presence of labels emanating from the father or an alien ... | 1990 | 2236255 |
| structure of class ii genes in wild mouse mus saxicola: functional and evolutionary implications. | class ii beta genes have been characterized from mus saxicola, a wild mouse which diverged five millions years ago from the house mouse. the nucleotide sequences of the exons 2 and 3 of e beta 1, a beta 2 and e beta 2 genes have been determined in order to define the molecular mechanisms of interspecies variability. the e beta 1 and a beta 1 (j. x. she, personal communication) genes from mus saxicola display extensive sequence variability in exon 2 when compared to those of the house mouse, in a ... | 1990 | 2369919 |
| a comparative study of mossy fiber distribution in the brain of the precocial acomys cahirinus and of the altricial rattus norvegicus: neuroanatomical bases and behavioral correlates. | acomys cahirinus, the spiny mouse, is the only precocial murid. given the relatively advanced state of neural maturation at birth, this species is therefore of interest for comparative studies of brain and behavioural development. previous work on this species has indicated that (i) hippocampal thickness (relative to body weight) is greater in adult acomys than in rats and mice; (ii) the hippocampus appears laminated at birth, unlike that of related altricial species; (iii) the degree of olfacto ... | 1985 | 2419270 |
| reduced early and late phase insulin response to glucose in isolated spiny mouse (acomys cahirinus) islets: a defective link between glycolysis and adenylate cyclase. | the spiny mouse (acomys cahirinus) exhibits low insulin responsiveness to glucose with a nearly absent early phase release. the alternative fuel-secretagogue glyceraldehyde (10 mmol/l) produced a maximal early insulin response in rat islets but failed to affect early response in acomys; however, it potentiated the late insulin response in both species alike. glucagon (1.5 mumol/l) potentiated the early insulin response to intermediate (8.3 mmol/l) glucose in rat and acomys islets by two- and fou ... | 1989 | 2477292 |
| the development of olfactory preferences for artificial odors briefly experienced by the precocial spiny mouse young. | groups of pups, aged 2, 4, 6, 12, 16, and 18 days of the precocial murid rodent spiny mouse (acomys cahirinus), were each exposed for 1.5 h to one of the experimental odors, cinnamon or cumin, present in the surrounding environment. the odors were not contingent upon home-cage odors or any other reinforcers. this simple exposure produced a strong preference for the exposed odor in multichoice preference tests carried out 48 h after the exposure in pups from groups aged 2 through 16 days. older p ... | 1989 | 2590153 |
| development of sex differences in the response of spiny mouse pups to adult male odors. | using a three-choice preference test, olfactory-mediated investigatory activity in response to adult male urine odor was examined in a precocially active rodent, the spiny mouse (acomys cahirinus) aged between 3-26 days. temporally related sex differences were seen in the time spent in the presence of the odors of father's or unfamiliar adult male's urine, or distilled (control) water. neither male nor female pups discriminated between odors from the father and strange adult males. after the fir ... | 1989 | 2629001 |
| a repeated segment on the mouse y chromosome is composed of retroviral-related, y-enriched and y-specific sequences. | we report the isolation and characterization of two recombinant clones containing dna derived from the y chromosome of the c57bl/10 inbred mouse strain. both clones were isolated from a lambda phage library derived from a partial ecori digest of c57bl/10 male dna using the murine retrovirus m720. characterization of these clones showed they were derived from a repeated segment present on the c57bl/10j y chromosome that contains sequences found elsewhere in the genome. in addition, one clone cont ... | 1989 | 2731728 |
| direct in utero perception of light by the mammalian fetus. | the primary neural pathway for entrainment of circadian rhythms in rodents is the retinohypothalamic tract, which conveys lighting information from the retina to a biological clock in the hypothalamic suprachiasmatic nuclei (scn). in a precocious rodent species, the spiny mouse, the retinohypothalamic tract is present and functioning within the scn on the day of birth, as assessed by hrp histochemistry and 14c-labeled 2-deoxyglucose autoradiography, respectively. furthermore, direct perception o ... | 1989 | 2736762 |
| trypanosoma acomys (wenyon, 1909): reproductive forms and course of parasitemia in the natural host acomys cahirinus (desmarest, 1819). | trypanosoma acomys (stercoraria, trypanosomatidae) was studied in the laboratory-bred spiny mouse acomys cahirinus. only trypomastigotes were found in peripheral blood, whereas the thymus of experimentally infected a. cahirinus showed amastigote syncytial reproductive forms whose nuclei of nuclei ranged from 2 to 128. these reproductive forms were detected 9-10 days after the i.p. injection of spiny mice with trypanosomes obtained from primary lung cultures. transitional trypomastigote-like form ... | 1989 | 2755930 |
| development of enzymic zonation in liver parenchyma is related to development of acinar architecture. | the appearance of the distribution patterns of the nh3-metabolizing enzymes carbamoylphosphate synthetase, glutamate dehydrogenase, and glutamine synthetase in the developing liver of an altricial species (rat) was compared with that in the developing liver of a closely related, precocial species (spiny mouse). the comparison showed that the development of hepatic acinar architecture, rather than perinatal adaptation, is responsible for the development of periportal and pericentral compartments ... | 1987 | 2895721 |
| effect of insulin and 2-deoxy-d-glucose on feeding and plasma glucose levels in the spiny mouse. | adult male spiny mice (acomys cahirinus) were challenged with 2-deoxy-d-glucose (2-dg) or regular insulin, and food intake or plasma glucose concentration was measured. mice did not increase their food intake over baseline levels following treatment with 2-dg (62.5-1000 mg/kg). in contrast, regular insulin injections (1-50 u/kg) stimulated a modest, but significant increase in feeding, which was apparent within 2 hr at a low dose of 1 u/kg. however, a marked hyper- and hypoglycemia (compared to ... | 1988 | 3070582 |
| the acomys cahirinus (spiny mouse) as a new model for biological and neurobehavioural studies. | acomys cahirinus is a precocial murid and a comparison of its development with altricial species of the same family, such as the rat and mouse, may shed some light on the relationship between genetic and environmental factors in the development. the use of acomys in neurobehavioural studies and its comparison with mouse and rat may be particularly profitable. behavioural, differences particularly in the exploratory behaviour, are paralleled by differences in the brain anatomy. therefore acomys s ... | 1988 | 3075753 |
| noradrenergic innervation of developing rat and spiny mouse liver. its relation to the development of the liver architecture and enzymic zonation. | the development of noradrenergic innervation of rat liver was studied with a polyclonal antiserum against noradrenaline. nerves are first seen in the larger portal vessels at day 1 after birth and reach their final distribution at 5 days after birth i.e. at the same time as the establishment of the acinar architecture and the heterogeneous distribution of nh3-metabolizing enzymes. the latter distribution of nerves is already seen at birth in the liver of the closely related but precocial spiny m ... | 1988 | 3394957 |
| [the features of the hippocampal structure as a neuroanatomical basis for differences in behavior]. | neuromorphological and behavioural studies have been made on several strains of mice (c57b1, dba/2, sec) and on the spiny mouse acomys cahirinus. it was shown that animals with different genotypes differ by the size of fascia dentata and by the extension of the pyramidal layer in ca3 field of the hippocamp. animals with a higher learning capacity exhibited smaller layer of granular cells in the fascia dentata, which may be due to a lower density of neurones in this region. terminals of the mossy ... | 1987 | 3434039 |
| postnatal maturation of brain cholinergic systems in the precocial murid acomys cahirinus: comparison with the altricial rat. | the spiny mouse (acomys cahirinus) is the only precocial murid species. it has some neuroanatomical peculiarities such as a relatively thin cerebral cortex and a large hippocampus. the levels of choline acetyltransferase, membrane-bound acetylcholinesterase and muscarinic receptor sites (measured as [3h]quinuclidynil benzilate binding) were assessed in the whole brain on days 1, 7, 14, 21, 28 and 80 (adult), and compared with those of wistar rats of the corresponding ages. at birth choline acety ... | 1986 | 3455597 |
| hormones in perinatal rat and spiny mouse: relation to altricial and precocial timing of birth. | rat (rattus norvegicus) and spiny mouse (acomys cahirinus) are closely related murine species that, due to their altricial (rat) and precocial (spiny mouse) modes of development, differ in the developmental timing of birth. a comparison between the developmental profiles of plasma glucagon, insulin, thyroxine, triiodothyronine, and glucocorticosteroid hormone was carried out to elucidate the question to what extent these hormonal profiles were related to the timing of birth. although corticoster ... | 1986 | 3524260 |
| [comparative study of the brain of developed and underdeveloped neonatal rodents of the muridae family]. | morphological studies have been made of the neocortical and archicortical structures in the spiny mouse acomys cahirinus, the only maturely born species from the family muridae. the data obtained reveal highly developed hippocampus as compared to the neocortex in this mouse, in contrast to relationships found in other mice and rats. | 1987 | 3564772 |
| opioid modulation of ingestive behaviors in the spiny mouse (acomys cahirinus). | feeding and drinking behavior were studied in deprived or sated spiny mice (acomys cahirinus) at various time intervals following peripheral administration of naloxone hydrochloride and butorphanol tartrate. naloxone attenuated both food and water intake, but not latency to respond, indicating existence of functional opioid-sensitive feeding and drinking systems in this species. butorphanol tartrate, a mixed opioid agonist/antagonist produced a dose-related enhancement or suppression of feeding, ... | 1987 | 3613855 |
| effects of intranasal znso4 irrigation are mitigated by the presence of untreated littermates. | observable anomalies were produced in spiny mouse neonates and weanlings through intranasal irrigation with znso4 solution. in comparison to control animals, znso4-treated pups displayed growth retardation, increased mortality rates, hyperactivity in a novel environment and difficulty in finding hidden food pellets. each of these experimentally-induced deficits was alleviated when treated pups were housed and tested in the presence of intact littermates. the early social environment exerts marke ... | 1987 | 3615658 |
| maternal-fetal communication of circadian phase in a precocious rodent, the spiny mouse. | the development of circadian rhythms was examined in a precocious rodent species, the spiny mouse. spiny mouse pups born and reared in constant darkness expressed robust circadian rhythms in locomotor activity as early as day 5 of life. free-running activity rhythms of pups born and reared in constant darkness were coordinated with the dam on the day of birth. postnatal maternal influences on pup rhythmicity are minimal in this species, as pups fostered on the day of birth to dams whose circadia ... | 1987 | 3661701 |
| effects of odor familiarity on the development of systematic exploration in the spiny mouse, acomys cahirinus. | developmental changes in patterns of exploration by infant spiny mice, acomys cahirinus are described. these were investigated using an unbaited radial maze and under three odor conditions; that is, animals were tested in the presence of either familiar (own) odors, unfamiliar conspecific odors, or no odors (washed floor). two hypotheses were tested. the first was based on the results of a pilot study, and was that adult animals would explore the radial maze in a systematic and predictable fashi ... | 1987 | 3691969 |
| correction of diabetic pattern of insulin release from islets of the spiny mouse (acomys cahirinus) by glucose priming in vitro. | insulin release kinetics were studied in perifused islets of langerhans, isolated from mildly hyperglycaemic and from normoglycaemic spiny mice (acomys cahirinus), a rodent predisposed to develop spontaneously non-ketotic diabetes. in both groups, insulin response to glucose (16.7 mmol/l) was delayed in comparison with that of rat islets, the release kinetics being analogous to that of human type 2 (non-insulin-dependent) diabetes. thirty min priming of the isolated acomys islets with glucose (1 ... | 1985 | 3894135 |
| perinatal development of the small intestine and pancreas in rat and spiny mouse. its relation to altricial and precocial timing of birth. | rat (rattus norvegicus) and spiny mouse (acomys cahirinus) are closely related species that mainly differ in the developmental timing of birth. a comparison between the developmental profiles of some characteristic enzymes of the small intestine (lactase and sucrase) and of the pancreas (amylase) of both species was carried out to elucidate the question to what extent these enzymic profiles and hence the maturation of these organs was related to the process of birth. it was found that these orga ... | 1985 | 3921064 |
| patterns of exploratory behavior in the spiny mouse, acomys cahirinus. | the present paper reports an investigation of patterns of exploratory behavior shown by laboratory-bred spiny mice (acomys cahirinus) when given access to a large, novel arena. the aim was to test hypotheses suggested by our previous work with this species. previous experiments in which the exploratory behavior of acomys was compared with that of mus had suggested that each species had a characteristic pattern of emergence and exploration. the present experiment addressed the question of whether ... | 1986 | 3954718 |
| perinatal development of the liver in rat and spiny mouse. its relation to altricial and precocial timing of birth. | rat (rattus norvegicus) and spiny mouse (acomys cahirinus) are closely related murinoid species that mainly differ in the developmental timing of birth. a comparison between the developmental profiles of some characteristic enzymes of the liver of both species was carried out to elucidate the question to what extent are these enzymic profiles and hence the maturation of the liver related to the timing of birth? it was found that these organotypic enzymes first become detectable at the same devel ... | 1985 | 3967668 |
| hyalomma (hyalommina) arabica: nymphal and larval identity and spiny mouse hosts in saudi arabia (acarina: ixodoidea: ixodidae). | nymphal and larval hyalomma (hyalommina) arabica pegram, hoogstraal, and wassef, 1982, described herein, closely resemble those of hyalomma (hyalommina) rhipicephaloides neumann, differing chiefly in body size (both stages), nymphal basis capituli and scutal proportional dimensions, and distinctness of larval coxal spurs. females of these species are also structurally similar but males differ in major critical characters. nymphs and larvae of both species parasitize the spiny mouse (acomys spp.) ... | 1985 | 4057007 |
| a breeding program for spontaneously diabetic experimental animals: psammomys obesus (sand rat) and acomys cahirinus (spiny mouse). | | 1968 | 4233365 |
| [autofluorescent granules in the ependyma of the recessus inframamillaris of the yellow spiny mouse (acomys cahirinus dimidiatus)]. | | 1972 | 4339918 |
| [electron microscope detection of biogenic amines in the medulla of the adrenal gland of the normoglycemic spiny mouse (acomys cahirinus)]. | by means of a modification of the reinecke salt method already described, characteristical amine containing granules have been demonstrated in the parenchymal cells of the adrenal medulla in normoglycemic spiny mice. by this method two types of granules have been discerned according to their different contrasts. the advantages of the modification method are discussed. | 1974 | 4377491 |
| the effect of dietary sucrose on plasma lipids and on the liver of the spiny mouse (acomys cahirinus). | | 1974 | 4419533 |
| ecology of the brown spiny mouse mus p. platythrix (bennett) and the indian field mouse mus b. booduga (gray). | | 1974 | 4442970 |
| haemoglobin of the spiny mouse (acomys cahirinus) (starch gel electrophoresis, chromatographic fractionation). | | 1972 | 4636757 |
| seasonal observations on the cairo spiny mouse, acomys cahirinus (e. geoffroy, st. hilaire, 1803) and its fleas in egypt. | | 1973 | 4804345 |
| [increase in number and size of the islands of langerhans with obesity and diabetes in the spiny mouse (acomys)]. | | 1966 | 4864459 |
| interstitial nephritis in the spiny mouse (acomys cahirinus) associated with klossiella sp. infection. | | 1970 | 5005922 |
| isolation and partial structural analysis of insulin from mouse (mus musculus) and spiny mouse (acomys cahirinus). | | 1972 | 5028210 |
| helminthic infection of cairo spiny mouse. acomys cahirinus (e. geoffroy, st. hilaire, 1803) in u.a.r. | | 1969 | 5393691 |
| schizogony in a piroplasm of the spiny mouse. | | 1969 | 5789079 |
| acanthocephala of the genus moniliformis from rodents of egypt with the description of a new species from the egyptian spiny mouse (acomys cahirinus). | | 1967 | 6066757 |
| perinatal development of the lung in rat and spiny mouse: its relation to altricial and precocial timing of birth. | rat and spiny mouse (acomys cahirinus) are closely related murinoid species that represent altricial (rat) and precocial (spiny mouse) modes of development. the late intrauterine developmental stages of the spiny mouse therefore seem comparable to the early extrauterine developmental stages of the rat. to elucidate the question to what extent the development of the lung is related to the developmental timing of birth, we have studied some enzymes involved in the de novo synthesis of phosphatidyl ... | 1984 | 6326867 |
| paternal behavior in the spiny mouse (acomys cahirinus). | the responsiveness of adult male spiny mice (acomys cahirinus) to both their own and alien precocial young was investigated. paternal behavior was manifested primarily by the males huddling with their offspring and the coordination of pup attendance between adult males and females. with less than 2 days exposure to their own neonates, males were found to discriminate between their own and alien young. experience plays an important role in the development of paternal behavior in spiny mice. males ... | 1984 | 6487216 |
| localization of hydroxysteroid dehydrogenases, glucose-6-phosphate dehydrogenase and diaphorase in the testis and epididymis of the brown spiny mouse, mus platythrix, bennet. | | 1984 | 6596802 |
| archicortex and neocortex in the precocial murid acomys cahirinus. a comparison with two altricial species: mus musculus and rattus norvegicus. | a morphological analysis of some structures of the archicortex and neocortex was performed in the acomys cahirinus (spiny mouse), the only precocial murid. the data obtained indicate that the spiny mouse brain is an interesting case of a largely developed hippocampus with respect to the neocortex when compared to the brains of the mouse and rat. the precocious pups of the spiny mouse present the peculiarity among murids of an early olfactory imprinting. | 1983 | 6668122 |
| delayed or biphasic glucose-induced insulin secretion of pancreatic islets isolated from spiny mice (acomys cahirinus) : relation to age of animals. | the dynamics of insulin release from spiny mouse perifused pancreatic islets was investigated. in agreement with earlier studies we found no initial (0-10 min) insulin secretion in response to glucose in islets prepared from mice up to 35 weeks of age. the islets of animals older than 40 weeks, however, were characterized by greater insulin content, and a restored typical biphasic insulin secretion profile. the results suggest that immediate glucose response is modified by environmental or other ... | 1980 | 6989661 |
| comparison of insulin secretion by the isolated perfused pancreas and perifused islets of the spiny mouse (acomys cahirinus). | the dynamics of glucose-stimulated insulin release were studied in the perfused pancreas and in isolated perifused islets of spiny mice. the pattern of insulin release induced by an increase of the glucose concentration from 2.8 mm to 16.7 mm was different in the two preparations. in the perfused pancreas there was an early insulin release contrasting with an absence of the early response in isolated islets. the later insulin release response (5 min to 30 min) was present and similar in both pre ... | 1981 | 7020305 |
| intermediary metabolism during the development of obesity and diabetes in the desert rodent acomys cahirinus. | the spiny mouse acomys cahirinus, which exhibits beta-cell hyperplasia but low insulin secretion in captivity responded with hyperlipidemia without obesity or diabetes on a sucrose diet and became obese, and glucose-intolerant on a diet of fat-rich seeds. a three-month sucrose diet induced a marked rise in the activity of regulatory enzymes of glycolysis and lipogenesis in the liver but not in adipose tissue. there was also increased energy waste on this diet evident from a three-fold rise in th ... | 1982 | 7118367 |
| the oestrous cycle of the spiny mouse (acomys cahirinus). | the oestrous cycle of the spiny mouse (acomys cahirinus), as determined by vaginal smears, is 11.1 +/- 1.9 (s.d.) days (n = 110). the vaginal smears show cell patterns similar to those seen in the rat, but secretion of mucus is greater than in the rat. the average age at vaginal opening is 45 +/- 2.77 (s.e.m.) days, but the first litter (sired by litter mates) did not occur until 103 +/- 4.04 (s.e.m.) days. the decidual response to uterine trauma indicates tha there is an active luteal phase. th ... | 1981 | 7193735 |
| karyotype of the indian spiny mouse resulted from tandem fusion of some of the house mouse chromosomes. | | 1980 | 7226898 |
| the response of the egyptian spiny mouse (acomys cahirinus) and two other species of commensal rodents to anticoagulant rodenticides. | the response of acomys cahirinus to three anticoagulant rodenticides was investigated in the laboratory. in contrast to the other commensal rodents rattus rattus and r. norvegicus, this species appears to be naturally very resistant to warfarin, difenacoum and brodifacoum. it is considered unlikely that anticoagulant poisons would be effective in the field for the control of a. cahirinus. | 1981 | 7240734 |
| experiential influences on the development of huddling preferences and "sibling" recognition in spiny mice. | the role of experience in the development of huddling preferences and sibling recognition by spiny mouse (acomys cahirinus) weanlings was investigated. in the 1st experiment, pups separated from their littermates and fostered onto unfamiliar females (and their offspring) on the day of birth, day 10, or day 20, subsequently showed preferential huddling with their foster littermates. huddling by biological siblings was as infrequent as huddling by unrelated, unfamiliar agemates. the 2nd study reve ... | 1981 | 7250526 |
| chromosome alteration and the development of tumors. xxiii. banding karyotype analyses of methylcholanthrene-induced tumors in the indian spiny mouse, mus platythrix, with special regard to the anomalies of chromosomes with nucleolar organizer regions. | in the indian spiny mouse, mus platythrix (2n = 26), six tumors were induced by 3-methylcholanthrene, and their karyotypes were analyzed in the primary state by g-banding. the chromosome numbers of these tumors were widely distributed ranging from diploid to tetraploid, but the frequency of cells exhibiting diploidy was the highest. among these cells, the frequency of the cells with a normal diploid karyotype was only 27%, but the remaining cells (73%) showed pseudo- or near-diploid karyotypes. ... | 1981 | 7284983 |
| development of the adult pelage in normal and hormone-injected spiny mice (acomys cahirinus). | the dorsal pelage of the adult egyptian spiny mouse (acomys cahirinus) consists primarily of coarse brittle spines which differ from those of the juvenile pelage. the development of the adult pelage in juvenile spiny mice was examined in normal and estradiol- or testosterone-injected animals. females complete the development of their adult pelage significantly faster than males. both estradiol and testosterone injections speed pelage development in males. testosterone causes a significant delay ... | 1981 | 7338723 |
| short term lithium-induced histological changes in thyroid & pituitary glands of the spiny mouse mus platythrix (bennett). | | 1980 | 7429561 |
| biotransformation in egyptian spiny mouse acomys cahirinus. | the activities of several representative biotransformation enzymes were determined in male and female spiny mouse tissues. cytochrome p450 monooxygenase activity toward benzo(a)pyrene was significantly greater in female spiny mouse intestine than in males. activity toward benzphetamine in both sexes was high in the liver, with little activity in the kidney and intestine. sulfotransferase activity was high in kidney and intestine of female spiny mice but undetectable in the same tissues in males. ... | 1995 | 7749597 |
| organ-to-body weight ratio in the egyptian spiny mouse acomys cahirinus. | | 1994 | 7933979 |
| cloning and sequence analysis of the gene and cdna encoding mouse spermidine/spermine n1-acetyltransferase--a gene uniquely regulated by polyamines and their analogs. | the polyamine catabolizing enzyme, spermidine/spermine n1-acetyltransferase (ssat), has been implicated as a critical determinant of polyamine pool maintenance. ssat has recently been shown to be positively regulated in human cell lines by polyamines and their analogs at the level of mrna accumulation. mouse la-4 lung adenoma cells treated with either spermine or the spermine analog, n1,n12-bis(ethyl)spermine, produced a 2.3 and 6.5-fold increase, respectively, in ssat mrna. prior evidence for t ... | 1993 | 8241266 |
| ultrastructure of kolmer's crystalloid in the pinealocytes of the common spiny mouse (acomys cahirinus dimidiatus). | light- and electron-microscopical observations revealed a rod-like inclusion body in the pinealocytes of the common spiny mouse (acomys cahirinus dimidiatus). ultrastructurally, the body is composed of a varying number of tubes whose wall consists of thin filaments aligned in helical arrangement. the inner and outer surface of the wall is covered with ribosome-like granules. based on a morphological analysis it is concluded that the body described in the present investigation is identical with k ... | 1993 | 8269483 |
| histochemical analysis of carbohydrate moieties and sugar-specific acceptors in the kidneys of the laboratory mouse and the golden spiny mouse (acomys russatus). | the aims of this work were to histochemically compare the pattern of lectin binding and endolectin expression in different portions of nephrons of two rodent species producing either normal hyperosmotic urine (the laboratory mouse) or highly concentrated urine (acomys russatus, the golden spiny mouse). a panel of biotinylated lectins and neoglycoproteins and the avidin-biotin-peroxidase complex technique were used on bouin's fixed, paraffin-embedded sections. various segments of the uriniferous ... | 1993 | 8305818 |
| stability of preference for odors after short-term exposure in young spiny mice. | the stability of olfactory preferences for artificial odors was studied in young spiny mouse pups (acomys cahirinus). subjects aged between 2 and 20 days were exposed to the odor of either cinnamon or cumin for 1.5 hr. the durability of preferences for the familiar versus novel odor was subsequently monitored in a three-choice preference test. the results suggest the existence of a sensitive phase for learning odor characteristics, through simple exposure, between days 2 and 18 of the pups' post ... | 1993 | 8440404 |
| molecular evidence that the spiny mouse (acomys) is more closely related to gerbils (gerbillinae) than to true mice (murinae). | spiny mice of the genus acomys traditionally have been classified as members of the murinae, a subfamily of rodents that also includes rats and mice with which spiny mice share a complex set of morphological characters, including a unique molar pattern. the origin and evolution of this molar pattern, documented by many fossils from southern asia, support the hypothesis of the monophyly of acomys and all other murinae. this view has been challenged by immunological studies that have suggested tha ... | 1993 | 8475093 |
| oxygen consumption and body temperature rhythms in the golden spiny mouse: responses to changes in day length. | the golden spiny mouse acomys russatus is a rock dwelling rodent which lives in extremely arid and hot habitats. in israel it is nocturnal except in areas in which it coexists with the common spiny mouse a. cahirinus. in such places it is diurnal. the daily rhythms of body temperature (tb) and oxygen consumption (vo2) were compared in mice acclimated to two different photoperiod regimes in the laboratory: 8l:16d (short day) and 16l:8d (long day) at a constant ambient temperature. the daily rhyth ... | 1995 | 8559790 |
| the cairo spiny mouse acomys cahirinus shows a strong affinity to the mongolian gerbil meriones unguiculatus. | the classification of the african spiny mice (genus acomys) within the muridae family of rodents has been fraught with controversy. morphological data suggest a close affinity between this group and true old world mice of the genus mus. however, the combined results of immunological, biochemical, and dna melting studies suggest that spiny mice should not even be considered as members of the murinae subfamily. to further elucidate the position of the spiny mice within the rodent phylogenetic tree ... | 1996 | 8583903 |
| patterns of divergence during evolution of alpha 1-proteinase inhibitors in mammals. | alpha 1-proteinase inhibitor (alpha 1-pi), a member of the serine proteinase inhibitor superfamily, has a primary role in controlling neutrophil elastase activity within the mammalian circulation. several studies have indicated that the reactive center region of alpha 1-pi, the amino acid sequence of which is critical to recognition of and binding to target proteinases, is highly divergent within and among species. this appears to be a consequence of accelerated rates of evolution that may have ... | 1996 | 8587500 |
| respiratory rhythm generation in a precocial rodent in vitro preparation. | in vitro preparations for studying the neural control of respiration consisting of brainstem and spinal cord regions isolated from the newborn (po-p1) precocial rodent, acomys cahirinus (spiny mouse) are described. spiny mice have a longer gestation period (39 days) than laboratory rats (22 days) and mice (20 days) and thus are born in a considerably more mature state. we sought to determine if in vitro preparations isolated from spiny mice would spontaneously generate a respiratory motor patter ... | 1996 | 8833542 |
| the impact of beta-adrenergic blockade on daily rhythms of melatonin and body temperature of golden spiny mice acomys russatus. | beta-adrenergic stimulation induces melatonin synthesis and non-shivering thermogenesis (nst) in rodents. the golden spiny mouse, acomys russatus is a nocturnal species capable of diurnal activity when coexisting with its congenitor the common spiny mouse a. cahirinus. we have investigated the impact of beta-adrenergic blockade on 6-sulphatoxymelatonin (6-smt--a metabolite and index of melatonin production) and body temperature (tb) daily rhythms in male a. russatus. mice were acclimated to an a ... | 1997 | 9252245 |
| histology and enzymatic activity in the postnatal development of limb muscles in rodents. | the present work examines how increases in spontaneous motor capabilities during postnatal development are reflected in enzymatic activity and the histology of hindlimb muscles of the dormouse (eliomys melanurus), the jird (meriones tristrami), the vole (microtus socialis), and the spiny mouse (acomys cahirinus). the precocial neonate of the spiny mouse had the most advanced developmental state of young myofibers with striations as early as 1 week after delivery. at the same age, the altricial n ... | 1998 | 9523911 |
| body temperature daily rhythms in the striped mouse rhabdomys pumilio: the effects of alpha and beta blockade. | body temperature (tb) daily rhythms and the effects of alpha and beta blockade were studied in the south african diurnal striped mouse rhabdomys pumilio. eleven mice (8 males and 3 females) with a body mass of 42.7+/-7.8 g (mean +/- sd) were tested. mice were acclimated to a 13 h:11 h light-dark photoperiod at an ambient temperature of 25 degrees c. to assess the daily rhythm of pineal melatonin secretion, urinary 6-sulfatoxymelatonin (6-smt) was determined. mice displayed a robust tb daily rhyt ... | 1998 | 9618013 |
| involvement of the pineal gland in daily scheduling of the golden spiny mouse. | the light-dark cycle is the major time cue for daily and seasonal scheduling of physiological activities. however, non-photic cues (e.g. environmental and social constraints) may also play a significant role. a natural model exists in the golden spiny mouse (acomys russatus) which is nocturnal when maintained alone but diurnal when sharing a habitat with its congener, the common spiny mouse (a. cahirinus). we have recently observed that the presence of a. cahirinus provokes a major change in the ... | 1998 | 9740312 |
| analysis of some biophysical and biochemical parameters of long bones of spiny mouse (acomys cahirinus) in its life cycle. | | 1999 | 10353008 |
| daily scheduling of the golden spiny mouse under photoperiodic and social cues. | a most important function of the circadian system is to ensure that behaviors and metabolism are appropriately timed with respect to the light/dark cycle and photoperiod. ecological constraints can perturb the daily schedules; would they also impair photoperiodic adaptations? a natural model exists in the golden spiny mouse (acomys russatus), which is nocturnal, but driven into diurnal activity when sharing the habitat with its congener, a. cahirinus. we show here that the presence of a. cahirin ... | 1999 | 10368937 |
| glutamine synthetase expression in perinatal spiny mouse liver. | the pronounced increase in the protein/mrna ratio of ammonia-metabolising enzymes in rat liver in the last prenatal week represents a clear example of a post-transcriptional level of control of gene expression. both the underlying mechanism, namely an increase in translational efficiency of the mrna and/or enhanced stability of the protein, and its importance for perinatal adaptation are unknown. we investigated this process in spiny mouse liver, because the comparison of rat and spiny mouse can ... | 1999 | 10411642 |
| differential behavioural and hormonal responses of voles and spiny mice to owl calls. | rodents usually respond to the presence of owls by reducing overall activity, in particular foraging. in this study, a playback of recorded tawny owl, strix aluco, calls was sufficient to induce a marked effect in the social (gunther's) vole, microtus socialis. some of the voles exposed to owl calls reduced their activity ('freeze' pattern) unlike control voles exposed to a human voice. other voles, however, dashed around the cage ('flee' pattern). owl calls also increased corticosterone levels ... | 1999 | 10564611 |