| retinal capillary basement membrane thickness in spiny mice (acomys cahirinus) with induced and spontaneous diabetes. | basement membrane thickness was measured in two groups of spiny mice (acomys cahirinus): one with spontaneous diabetes, the other with streptozotocin-induced diabetes. a statistical analysis of the morphometric results of the two groups showed a significant basement membrane thickening in the group with induced diabetes when compared to the spontaneously diabetic group. | 1975 | 124711 |
| defective insulin secretion in the spiny mouse (acomys cahirinus). possible value in the study of the pathophysiology of diabetes. | | 1975 | 169217 |
| defective early phase insulin release in perifused isolated pancreatic islets of spiny mice (acomys cahirinus). | in order to characterize pancreatic beta cell function in geneva bred spiny mice (acomys cahirinus), the dynamics of immunoreactive insulin release were examined during perifusion of pancreatic islets isolated from normoglycemic acomys. the initial insulin response of acomys was slow: no clear-cut early (1 to 10 min) peak of insulin release was observed when glucose in the perifusion medium was abruptly raised from 2.8 mm to concentrations as high as 56 mm. this was true for islets of either you ... | 1975 | 171800 |
| glucose production by the perfused liver of the spiny mouse (acomys cahirinus): sensitivity to glucagon and insulin. | hepatic glucose production and its responses to glucagon and insulin were studied in perfused livers obtained from spiny mice (acomys cahirinus)--rodents characterized by normoglycemia, decreased glucose tolerance and decreased insulin secretion--and from swiss albino mice. the dose-response characteristics of glucagon-induced hepatic glucose output were similar in spiny and albino mice. however, maximally stimulated glucose production were significantly lower in the spiny mouse. furthermore, th ... | 1979 | 468520 |
| helminths of birds and mammals of israel. viii.- skrjabinocapillaria rodentium n. sp. (nematoda capillariidae) from gerbillid and murid rodents. | skrjabinocapillaria rodentium n.sp., found in the stomach of meriones crassus, gerbillus pyramidum, g. gerbillus, g. dasyurus and acomys cahirinus, is described. it differs from the other two species in the genus, s. bakeri and s. eubursata, mainly in being larger, having a larger number of stichocytes and having a cephalic influation in the female and not in the male. | 1979 | 485042 |
| the reproductive tract of the male spiny mouse (acomys cahirinus) and coagulation studies with other species. | the testes of the spiny mice showed asymmetry, the left being significantly heavier than the right (p = 0.025). histological studies indicated that spermatozoa were first present in the testes of animals 35--45 days of age but the maturation of the accessory glands, especially the lateral prostates and coagulating glands, occurred later. the highest fructose concentration in the adult was in the lateral prostates (126.97 +/- 22.23 mg fructose/100 g, n = 5) and coagulating glands (99.38 +/- 17.65 ... | 1979 | 513000 |
| significance of anomalous thermoregulation in the pre-diabetic spiny mouse (acomys cahirinus): oxygen consumption and temperature regulation. | in keeping with studies of other desert rodents, the potentially diabetic spiny mouse has been demonstrated to have a very low basal metabolic rate, disproportionate to its body weight. the maintenance of a lower body temperature in response to high environmental temperatures and a lack of increase in metabolic rate in response to cooling have also been demonstrated. assessments of "mechanical efficiency" have shown that spiny mice carry a potential selective advantage under fasting conditions. ... | 1977 | 603467 |
| significance of anomalous thermoregulation in the pre-diabetic spiny mouse (acomys cahirinus): cold tolerance: blood glucose and food consumption responses to environmental heat. | decreased cold tolerance, reduced food requirement for body weight maintenance and comparative resistance to the hypoglycaemic effect of fasting in high ambient temperatures have been demonstrated in the spiny mouse. these phenomena could be related to anomalous spiny mouse thermoregulation, a phenomenon which is common in desert rodents and is simulated by mutant and artificially diabetic rodent species. the data can be interpreted as showing evidence for a survival advantage of genotypes with ... | 1977 | 603468 |
| breeding and reproduction of fifteen wild rodents maintained as laboratory colonies. | data on reproduction and production were presented for laboratory colonies of microtus pennsylvanicus tananaensis, m oeconomus macfarlani, m o operarius, m mirurus, m abbreviatus, lemmus lemmus, l sibiricus trimucronatus, dicrostonyx stevensoni, clethrionomys rutilus, peromyscus maniculatus borealis, p m bairdii, baiomys taylori, calomys ducilla, c callosus, acomys cahirinus. litter size varied from 2.0 in a cahirinus to 5.5 in c callosus. infant (neonatal) and juvenile losses through the end of ... | 1976 | 775192 |
| proinsulin synthesis in islets of langerhans from spiny mice (acomys cahirinus). comparison with rats and mice. | proinsulin synthesis in response to different concentrations of glucose has been studied in islets of langerhans of acomys, rat and mouse. the response to increased glucose was small in acomys when compared with rat or mouse. the time course of the effect of glucose on proinsulin synthesis was also studied in sequential 15 min periods up to 60 min. with 5.5 mm glucose the rate of 3h-leucine incorporation for acomys islets were greater over the periods 15-30, 30-45 and 45-60 min after the additio ... | 1976 | 789163 |
| maternal pheromone in the spiny mouse (acomys cahirinus). | | 1976 | 944929 |
| an apparent abnormaltiy of the b-cell microtubular system in spiny mice (acomys cahirinus). | the pancreatic b-cell contains microtubules, which are thought to participate in the process of insulin release. in order to disclose a possible abnormaltiy of this b-cell microtubular system in animals with islet dysfunction, isolated islets from normal rats and mice, as well as from diabetic mutant mice (dbm mice) and from spiny mice (acomys cahirinus) were incubated in the presence of vincristine, which causes the precipitation of the microtubular protein into paracrystalline deposits. ultras ... | 1975 | 1095441 |
| insulin secretion in the spiny mouse (acomys cahirinus). dose and time kinetic studies with glucose in vivo and in vitro. | plasma insulin responses to the intravenous injection of glucose in the doses of 0.5, 1.5, and 3.0 gm./kg. were compared in spiny mice (acomys cahirinus) and weight-matched swiss albino mice. the mean early (two-minute) plasma insulin response was significantly lower in acomys at all doses of glucose injected; whereas, at later times (5, 15, and 30 minutes), differences in plasma insulin concentrations in the two species of mice were smaller or nonexistent. plasma glucose clearance was significa ... | 1975 | 1104397 |
| ultrastructure of the oocytes of the egyptian sping mouse (acomys cahirinus). | the oocytes of types 2, 3, 4 and 5 follicles from the normal spiny mouse were examined withe the electron microsome. multiple juxtanuclear golgi bodies, mitochondria associated with flattened granular endoplasmic reticulum, and large nucleus are the main features of the type 2 follicle oocyte. the numbers of mitochondria and golgi apparati increase significantly at later stages. small mitochondrial aggregates lacking "intermitochondrial cement" are seen in the ooplasm of types 3, 4 and 5 follicl ... | 1975 | 1171638 |
| breeding and fertility of the egyptian spiny mouse, acomys cahirinus: effect of different environments. | 2 years experience with acomys in one laboratory confirmed the slow breeding rate found by other workers. on moving the animals to another laboratory there was a 2-5 fold increase in breeding rate. the most likely explanation of this change was the presence of copper in the drinking water at the 1st laboratory, due to the use of copper water pipes. the data relating to maintenance and breeding of acomys for 2 years at the 2nd laboratory were analyzed to provide a more representative picture of t ... | 1976 | 1256010 |
| naturally occurring degrading events in axon terminals of the dentate gyrus and stratum lucidum in the spiny mouse (acomys cahirinus) during maturation, adulthood and aging. | the naturally occurring dynamics of presynaptic axon terminals were investigated in the dentate gyrus and stratum lucidum of the spiny mouse (acomys cahirinus) during maturation, adulthood and aging. a sensitive and selective silver-staining technique was applied to analyze neuronal lysosome accumulation (la), indicating synaptic degradation during development. la was quantified by counting silver grains in the inner third and outer two thirds of the molecular layer, granular layer, and the infr ... | 1992 | 1286623 |
| a relationship between circulating natural glucocorticoids and the mechanical responses of the heart in atricial and precocial rodents. | 1. a comparison was made of the mechanical performance of heart muscle from mouse, an atricial mammal, with corticosterone as glucocorticoid and spiny mouse (acomys cahirinus), a precocial mammal, with cortisol as glucocorticoid. 2. force-frequency responses were negative in mouse and positive in spiny mouse. 3. during recovery, there was a gradual increase and an overshoot in the mouse, while in the spiny mouse there was an initial enhanced response, diminishing gradually with time. 4. high cal ... | 1992 | 1361898 |
| distance perception in the spiny mouse acomys cahirinus: vertical jumping. | acomys cahirinus, a precocial muroid, that has shown precise jumping in the natural habitat, did not jump from 25 cm in a laboratory situation. to investigate this further, a. cahirinus were observed jumping from platforms at two different heights, onto different sized checkered substrates and from a visual cliff. adult animals discriminated between platforms that were 6.4 cm and 25.4 cm above the substrate and between small and large checkered patterns on the floor. most adult animals and neona ... | 1992 | 1454491 |
| [a morphometric study of postnatal synaptogenesis in the neocortex of precocial and altricial rodents]. | quantitative electronmicroscopic studies have been made on the development of synapses in two modally different areas of the brain (v-vi layers of the visual and auditory cortex) in the rat and mouse acomys cahirinus within first two weeks of their postnatal life. the density of synapses as well the relative amount of different types of synapses (symmetrical, asymmetrical, axo-spinal and synapses with large amounts of synaptic vesicles) were measured. it was shown that only in rats the developme ... | 1992 | 1523896 |
| behavioral response of altricial and precocial rodent fetuses to acute umbilical cord compression. | norway rat fetuses (rattus norvegicus) exhibit a stereotypic behavioral response when the umbilical cord is experimentally compressed with a vascular clamp. in this study, the development of the fetal behavioral response to cord compression was compared in altricial and precocial rodents, which differ markedly in neural and motor maturity at the time of birth. both altricial and precocial species showed some form of behavioral response to umbilical cord compression. fetuses of two altricial spec ... | 1992 | 1586357 |
| drinking behavior in the spiny mouse (acomys cahirinus) following putative dipsogenic challenges. | male spiny mice (acomys cahirinus) were challenged with several putative dipsogenic stimulus conditions: hypertonic sodium chloride (nacl), 24-h water deprivation, d,l-isoproterenol hcl, angiotensin ii (aii) and polyethylene glycol (peg), or control conditions, in within-subjects designs. water intake and drinking pattern were monitored electronically in the home cage over a 2--6-h test period without food present, during the light portion of the l/d cycle. in addition, hematocrits were measured ... | 1991 | 1871204 |
| differences in beta-adrenergic regulation of cyclic amp formation in cerebral cortical slices of the rat and spiny mouse--acomys cahirinus. | in both the rat and acomys cahirinus the adrenergic cyclic amp generating system in the brain is dependent not only on beta-, but also on alpha-adrenoceptors. the relative role of alpha-adrenoceptors is much greater in the acomys cahirinus. this feature makes the acomys an interesting animal model for investigating the role of alpha-beta-adrenoceptor coupling in generation of cyclic amp and the mechanism of action of antidepressant treatment. | 1990 | 1980732 |
| effect of exogenous insulin on meal patterns and stomach emptying in the spiny mouse. | male adult spiny mice (acomys cahirinus) were acutely challenged with a single dose of regular insulin or saline vehicle sc; either food intake, meal frequency and meal duration, or stomach emptying were then measured. meal frequency, as well as amount eaten, was significantly higher over a 6-hr period following both 10 and 30 u/kg of insulin than following vehicle injection. meal duration remained essentially the same across all conditions. when 30 u/kg of insulin was administered either 15 min ... | 1990 | 2201984 |
| animals as reservoir hosts for leishmania in qualyobia governorate, egypt. | a total of 239 rodents were collected from el-khanka, shebin el-kanater, el-kanater, shoubra el khima, qualiob, tokh, benha and kafr-shokr and identified as mus musculus (30), rattus rattus (78), rattus norvegicus (35), arvicanthus niloticus (62) and acomys cahirinus (34). examination of these rodents showed the presence of cutaneous lesions in two r. rattus, three r. norvegicus and one a. cahirinus which showed no leishmania parasites neither by smear nor by culture. on examination of the liver ... | 1990 | 2230335 |
| the influence of maternal labels on dietary preferences of spiny mouse weanlings. | to assess the influence of conspecific chemical cues on the development of dietary preferences, spiny mouse (acomys cahirinus) weanling were tested for their responses to food items that were partially eaten (thus, presumably labeled) by various categories of conspecifics. consumption of a highly preferred novel food (fresh carrot) labeled by the pups' parents, or mother alone, was greater than that of a clean sample of the same food. the presence of labels emanating from the father or an alien ... | 1990 | 2236255 |
| a comparative study of mossy fiber distribution in the brain of the precocial acomys cahirinus and of the altricial rattus norvegicus: neuroanatomical bases and behavioral correlates. | acomys cahirinus, the spiny mouse, is the only precocial murid. given the relatively advanced state of neural maturation at birth, this species is therefore of interest for comparative studies of brain and behavioural development. previous work on this species has indicated that (i) hippocampal thickness (relative to body weight) is greater in adult acomys than in rats and mice; (ii) the hippocampus appears laminated at birth, unlike that of related altricial species; (iii) the degree of olfacto ... | 1985 | 2419270 |
| reduced early and late phase insulin response to glucose in isolated spiny mouse (acomys cahirinus) islets: a defective link between glycolysis and adenylate cyclase. | the spiny mouse (acomys cahirinus) exhibits low insulin responsiveness to glucose with a nearly absent early phase release. the alternative fuel-secretagogue glyceraldehyde (10 mmol/l) produced a maximal early insulin response in rat islets but failed to affect early response in acomys; however, it potentiated the late insulin response in both species alike. glucagon (1.5 mumol/l) potentiated the early insulin response to intermediate (8.3 mmol/l) glucose in rat and acomys islets by two- and fou ... | 1989 | 2477292 |
| the development of olfactory preferences for artificial odors briefly experienced by the precocial spiny mouse young. | groups of pups, aged 2, 4, 6, 12, 16, and 18 days of the precocial murid rodent spiny mouse (acomys cahirinus), were each exposed for 1.5 h to one of the experimental odors, cinnamon or cumin, present in the surrounding environment. the odors were not contingent upon home-cage odors or any other reinforcers. this simple exposure produced a strong preference for the exposed odor in multichoice preference tests carried out 48 h after the exposure in pups from groups aged 2 through 16 days. older p ... | 1989 | 2590153 |
| prenatal neurogenesis in the telencephalon of the precocial mouse acomys cahirinus. | [3h]thymidine autoradiography was employed to examine the times of formation of the major neuronal classes in the forebrain of the precocial mouse acomys cahirinus. dams received 3 thymidine injections over a 24 h period on either embryonic day 14, 18, 20, 22, 29 or 36. age-related changes in the distribution and number of heavily labeled cells were noted. acomys exhibited later onset and more protracted periods of cell generation than the phylogenetically related, altricial laboratory rat or mo ... | 1989 | 2616023 |
| development of sex differences in the response of spiny mouse pups to adult male odors. | using a three-choice preference test, olfactory-mediated investigatory activity in response to adult male urine odor was examined in a precocially active rodent, the spiny mouse (acomys cahirinus) aged between 3-26 days. temporally related sex differences were seen in the time spent in the presence of the odors of father's or unfamiliar adult male's urine, or distilled (control) water. neither male nor female pups discriminated between odors from the father and strange adult males. after the fir ... | 1989 | 2629001 |
| trypanosoma acomys (wenyon, 1909): reproductive forms and course of parasitemia in the natural host acomys cahirinus (desmarest, 1819). | trypanosoma acomys (stercoraria, trypanosomatidae) was studied in the laboratory-bred spiny mouse acomys cahirinus. only trypomastigotes were found in peripheral blood, whereas the thymus of experimentally infected a. cahirinus showed amastigote syncytial reproductive forms whose nuclei of nuclei ranged from 2 to 128. these reproductive forms were detected 9-10 days after the i.p. injection of spiny mice with trypanosomes obtained from primary lung cultures. transitional trypomastigote-like form ... | 1989 | 2755930 |
| a comparative study of prenatal development in the olfactory bulb, neocortex and hippocampal region of the precocial mouse acomys cahirinus and rat. | unlike the remainder of the rodent subfamily muridae, acomys cahirinus (the 'spiny' mouse) is born in a precocial state after a long (39 day) gestation. in this paper, the development of the olfactory bulb, neocortex and hippocampal formation of acomys from prenatal days 14-34 was examined and the rate of maturation compared with that of its cousin, the laboratory rat (rattus norvegicus). at the earliest stages examined, acomys was approximately 2 days less mature than the same post-conception a ... | 1989 | 2791267 |
| a comparison of locomotor responses to some psychotropic drugs and cerebral receptors in the acomys cahirinus and the laboratory mouse. | comparative studies of the laboratory mouse and acomys cahirinus have shown differences in their motor activity patterns and motor responses to morphine, apomorphine and clonidine. the two species also differed in respect of the density of cerebral alpha 2-adrenergic receptors, but no significant differences between other types of receptors (alpha 1-adrenergic, beta-adrenergic, opiate mu and delta, and spiroperidol binding sites) were found. it is suggested that the high excitability of the acom ... | 1987 | 2830608 |
| a comparison of postnatal thermal physiology and energetics in an altricial (gerbillus perpallidus) and a precocial (acomys cahirinus) rodent species. | 1. daily weight increase is polyphasic in gerbillus perpallidus whereas it follows a linear pattern in acomys cahirinus. 2. young a. cahirinus achieve full homeothermic capacities much earlier (less than or equal to 12 days old) than g. perpallidus (19-21 days old). 3. the differences in the development of the two species are reflected in the alterations of their metabolic rates. 4. in both species, age-dependent phases of development are obvious, beginning, however, much later in g. perpallidus ... | 1988 | 2900101 |
| electrophysiological effects of dopamine receptor stimulation in the hippocampus of acomys cahirinus. | the effect of dopamine receptor agonists on the spontaneous bioelectrical activity of ca1 layer neurons in the hippocampal slice preparation from the acomys and rat has been studied. the selective d1 receptor agonist skf 38393 diminished the neuronal firing rate while the selective d2 receptor agonist ly 171555 (quinpirole) evoked an excitatory reaction, however, a great proportion of hippocampal neurons remained unresponsive to skf 38393 and ly 171555. both dopamine and apomorphine elicited mai ... | 1988 | 2908137 |
| effect of insulin and 2-deoxy-d-glucose on feeding and plasma glucose levels in the spiny mouse. | adult male spiny mice (acomys cahirinus) were challenged with 2-deoxy-d-glucose (2-dg) or regular insulin, and food intake or plasma glucose concentration was measured. mice did not increase their food intake over baseline levels following treatment with 2-dg (62.5-1000 mg/kg). in contrast, regular insulin injections (1-50 u/kg) stimulated a modest, but significant increase in feeding, which was apparent within 2 hr at a low dose of 1 u/kg. however, a marked hyper- and hypoglycemia (compared to ... | 1988 | 3070582 |
| the acomys cahirinus (spiny mouse) as a new model for biological and neurobehavioural studies. | acomys cahirinus is a precocial murid and a comparison of its development with altricial species of the same family, such as the rat and mouse, may shed some light on the relationship between genetic and environmental factors in the development. the use of acomys in neurobehavioural studies and its comparison with mouse and rat may be particularly profitable. behavioural, differences particularly in the exploratory behaviour, are paralleled by differences in the brain anatomy. therefore acomys s ... | 1988 | 3075753 |
| a comparative study of myelination in precocial and altricial murid rodents. | the development of myelin staining was compared in two closely related rodent species, the precocial acomys cahirinus and altricial rattus norvegicus. while the progression of myelin staining was similar in both species (motor tracts myelinated before sensory systems, which were followed by forebrain fiber systems), the timing of maturation differed considerably: (1) at the same postconception age (pc38) rattus was substantially more mature than acomys, suggesting a relatively earlier onset of m ... | 1988 | 3219591 |
| species differences in hepatic microsomal drug-metabolizing enzymes. | the activity of some metabolizing enzymes was assessed in the liver microsomes of acomys cahirinus, mice and rats. the enzymatic studies were followed by the determination of cerebral level of apomorphine (apo), imipramine (imi) and its metabolite desipramine (dmi) of animals treated with a single dose of apo or imi. it was found that the level of cytochrome p-450 and the activity of imi demethylase and glucuronyltransferase in the liver microsomes of rats was significantly higher than those in ... | 1988 | 3222176 |
| a comparison of norepinephrine stimulated inositol phosphate accumulation in cerebral cortex of the acomys cahirinus, the laboratory mice and the rat. | | 1988 | 3222183 |
| brain choline acetyltransferase and muscarinic receptor sites, brain and liver cholinesterases in precocial acomys cahirinus and altricial rat during post-natal development. | brain choline acetyltransferase, acetylcholinesterase with its molecular forms, and muscarinic receptor sites, as well as liver total cholinesterases were evaluated during the first postnatal month in pups of a precocial (acomys cahirinus) and altricial (rat) murid species. at birth the levels of brain cholinergic markers were higher in the acomys than in the rat, but in adulthood the differences were smaller or even reversed. the postnatal increase up in the markers to weaning was considerably ... | 1988 | 3253718 |
| precocity and plasticity: odor deprivation and brain development in the precocial mouse acomys cahirinus. | altering the early olfactory environment of animals can have dramatic consequences on the development of brain regions which subserve olfaction. the present study indicates that early odor deprivation has a more severe effect on a species which is born relatively mature than it does on related species which are not. the results call into question prevailing notions about the developmental continuity between animals born in divergent ontogenetic states. | 1988 | 3362353 |
| [the features of the hippocampal structure as a neuroanatomical basis for differences in behavior]. | neuromorphological and behavioural studies have been made on several strains of mice (c57b1, dba/2, sec) and on the spiny mouse acomys cahirinus. it was shown that animals with different genotypes differ by the size of fascia dentata and by the extension of the pyramidal layer in ca3 field of the hippocamp. animals with a higher learning capacity exhibited smaller layer of granular cells in the fascia dentata, which may be due to a lower density of neurones in this region. terminals of the mossy ... | 1987 | 3434039 |
| postnatal maturation of brain cholinergic systems in the precocial murid acomys cahirinus: comparison with the altricial rat. | the spiny mouse (acomys cahirinus) is the only precocial murid species. it has some neuroanatomical peculiarities such as a relatively thin cerebral cortex and a large hippocampus. the levels of choline acetyltransferase, membrane-bound acetylcholinesterase and muscarinic receptor sites (measured as [3h]quinuclidynil benzilate binding) were assessed in the whole brain on days 1, 7, 14, 21, 28 and 80 (adult), and compared with those of wistar rats of the corresponding ages. at birth choline acety ... | 1986 | 3455597 |
| hormones in perinatal rat and spiny mouse: relation to altricial and precocial timing of birth. | rat (rattus norvegicus) and spiny mouse (acomys cahirinus) are closely related murine species that, due to their altricial (rat) and precocial (spiny mouse) modes of development, differ in the developmental timing of birth. a comparison between the developmental profiles of plasma glucagon, insulin, thyroxine, triiodothyronine, and glucocorticosteroid hormone was carried out to elucidate the question to what extent these hormonal profiles were related to the timing of birth. although corticoster ... | 1986 | 3524260 |
| [comparative study of the brain of developed and underdeveloped neonatal rodents of the muridae family]. | morphological studies have been made of the neocortical and archicortical structures in the spiny mouse acomys cahirinus, the only maturely born species from the family muridae. the data obtained reveal highly developed hippocampus as compared to the neocortex in this mouse, in contrast to relationships found in other mice and rats. | 1987 | 3564772 |
| opioid modulation of ingestive behaviors in the spiny mouse (acomys cahirinus). | feeding and drinking behavior were studied in deprived or sated spiny mice (acomys cahirinus) at various time intervals following peripheral administration of naloxone hydrochloride and butorphanol tartrate. naloxone attenuated both food and water intake, but not latency to respond, indicating existence of functional opioid-sensitive feeding and drinking systems in this species. butorphanol tartrate, a mixed opioid agonist/antagonist produced a dose-related enhancement or suppression of feeding, ... | 1987 | 3613855 |
| species differences in polysaccharide and sugar taste preferences. | this study compared the polysaccharide and sugar taste preferences of humans and four rodent species (laboratory rats, rattus norvegicus; golden syrian hamsters, mesocricetus auratus; mongolian gerbils, meriones unguiculatus; egyptian spiny mice, acomys cahirinus). in experiment 1 human subjects rated the pleasantness, sweetness, and flavor intensity of polysaccharide (polycose), sucrose, and maltose solutions at concentrations of 0.0125 m to 0.4 m, and 1% to 32% concentrations. at the higher mo ... | 1987 | 3614791 |
| effects of odor familiarity on the development of systematic exploration in the spiny mouse, acomys cahirinus. | developmental changes in patterns of exploration by infant spiny mice, acomys cahirinus are described. these were investigated using an unbaited radial maze and under three odor conditions; that is, animals were tested in the presence of either familiar (own) odors, unfamiliar conspecific odors, or no odors (washed floor). two hypotheses were tested. the first was based on the results of a pilot study, and was that adult animals would explore the radial maze in a systematic and predictable fashi ... | 1987 | 3691969 |
| correction of diabetic pattern of insulin release from islets of the spiny mouse (acomys cahirinus) by glucose priming in vitro. | insulin release kinetics were studied in perifused islets of langerhans, isolated from mildly hyperglycaemic and from normoglycaemic spiny mice (acomys cahirinus), a rodent predisposed to develop spontaneously non-ketotic diabetes. in both groups, insulin response to glucose (16.7 mmol/l) was delayed in comparison with that of rat islets, the release kinetics being analogous to that of human type 2 (non-insulin-dependent) diabetes. thirty min priming of the isolated acomys islets with glucose (1 ... | 1985 | 3894135 |
| perinatal development of the small intestine and pancreas in rat and spiny mouse. its relation to altricial and precocial timing of birth. | rat (rattus norvegicus) and spiny mouse (acomys cahirinus) are closely related species that mainly differ in the developmental timing of birth. a comparison between the developmental profiles of some characteristic enzymes of the small intestine (lactase and sucrase) and of the pancreas (amylase) of both species was carried out to elucidate the question to what extent these enzymic profiles and hence the maturation of these organs was related to the process of birth. it was found that these orga ... | 1985 | 3921064 |
| patterns of exploratory behavior in the spiny mouse, acomys cahirinus. | the present paper reports an investigation of patterns of exploratory behavior shown by laboratory-bred spiny mice (acomys cahirinus) when given access to a large, novel arena. the aim was to test hypotheses suggested by our previous work with this species. previous experiments in which the exploratory behavior of acomys was compared with that of mus had suggested that each species had a characteristic pattern of emergence and exploration. the present experiment addressed the question of whether ... | 1986 | 3954718 |
| perinatal development of the liver in rat and spiny mouse. its relation to altricial and precocial timing of birth. | rat (rattus norvegicus) and spiny mouse (acomys cahirinus) are closely related murinoid species that mainly differ in the developmental timing of birth. a comparison between the developmental profiles of some characteristic enzymes of the liver of both species was carried out to elucidate the question to what extent are these enzymic profiles and hence the maturation of the liver related to the timing of birth? it was found that these organotypic enzymes first become detectable at the same devel ... | 1985 | 3967668 |
| a stereological study of neocortical maturation in the precocial mouse, acomys cahirinus. | the development of neocortical area 17 of acomys cahirinus was studied by quantifying changes in the numerical density of neurons and glia, and by examinations of subjects treated on the day of birth with tritiated thymidine. unlike most laboratory species, acomys is born in a relatively advanced state, with open and functional ears and eyes and coordinated locomotor abilities. rapid neocortical growth occurred during the first 60 postnatal days and was accompanied by a 65% decrease in neuronal ... | 1985 | 3995352 |
| exploratory behavior of two species of murid rodents, acomys cahirinus and mus musculus: a comparative study. | the exploratory behavior of two species of murid rodents, acomys cahirinus and mus musculus, was compared in four experiments: in the first, the responses of the two species to a novel arena were studied. mus was found to take longer to enter the arena, and to spend more time in the relatively familiar or safer start box, than was acomys. the results suggest that acomys may persevere longer in exploring particular areas, whereas mus appear to explore in the open arena by using frequent shifts of ... | 1985 | 4004686 |
| a breeding program for spontaneously diabetic experimental animals: psammomys obesus (sand rat) and acomys cahirinus (spiny mouse). | | 1968 | 4233365 |
| [autofluorescent granules in the ependyma of the recessus inframamillaris of the yellow spiny mouse (acomys cahirinus dimidiatus)]. | | 1972 | 4339918 |
| metabolic adaptation of spiny mice (acomys cahirinus) transferred from the desert to laboratory diets. | | 1974 | 4370735 |
| evidence for decreased sensitivity to glucose of isolated islets from spiny mice. (acomys cahirinus). | | 1974 | 4375063 |
| [electron microscope detection of biogenic amines in the medulla of the adrenal gland of the normoglycemic spiny mouse (acomys cahirinus)]. | by means of a modification of the reinecke salt method already described, characteristical amine containing granules have been demonstrated in the parenchymal cells of the adrenal medulla in normoglycemic spiny mice. by this method two types of granules have been discerned according to their different contrasts. the advantages of the modification method are discussed. | 1974 | 4377491 |
| testosterone biosynthesis in the desert mouse, acomys cahirinus. | | 1971 | 4399441 |
| the effect of dietary sucrose on plasma lipids and on the liver of the spiny mouse (acomys cahirinus). | | 1974 | 4419533 |
| haemoglobin of the spiny mouse (acomys cahirinus) (starch gel electrophoresis, chromatographic fractionation). | | 1972 | 4636757 |
| seasonal observations on the cairo spiny mouse, acomys cahirinus (e. geoffroy, st. hilaire, 1803) and its fleas in egypt. | | 1973 | 4804345 |
| recent advances in mechanism of causation of diabetes mellitus in man and acomys cahirinus. | | 1974 | 4858609 |
| [the autonomous nervous system and the b-cell: metabolic and morphological observations made in spiny mice (acomys cahirinus) and in cultured fetal rat pancreas]. | | 1970 | 4919942 |
| interstitial nephritis in the spiny mouse (acomys cahirinus) associated with klossiella sp. infection. | | 1970 | 5005922 |
| isolation and partial structural analysis of insulin from mouse (mus musculus) and spiny mouse (acomys cahirinus). | | 1972 | 5028210 |
| helminthic infection of cairo spiny mouse. acomys cahirinus (e. geoffroy, st. hilaire, 1803) in u.a.r. | | 1969 | 5393691 |
| [on the cerebralization of the nest-escaping acomys (cahirinus) minous (bate, 1906) in comparison with the nest-dwelling (albino mouse, apodemus sylvaticus (linnaeus, 1758) and albino rat). ii. morphology and allometry of postnatal brain development of acomys (cahirinus) minous, of the albino mouse, and of the albino rat]. | | 1968 | 5719048 |
| [the myelogenesis of a nidifugious type (acomys (cahirinus) minous, bate 1906) in comparison to a nidicolous type (albino mouse)]. | | 1967 | 6053711 |
| acanthocephala of the genus moniliformis from rodents of egypt with the description of a new species from the egyptian spiny mouse (acomys cahirinus). | | 1967 | 6066757 |
| response of hepatic fructokinase to long-term sucrose diets and diabetes in spiny mice, albino mice and rats. | the activity of hepatic fructokinase increased about 2-fold in desert-derived spiny mice (acomys cahirinus) and laboratory bred albino mice and rats, maintained on a 50% sucrose diet for 3 months. the role of fructose as the specific inducer was apparent, as 25% fructose diet produced activity increases similar to those of sucrose in contrast to 25% glucose diet. the activity of hexokinase was not affected by the sucrose diet, that of glucokinase rose marginally but those of pyruvate kinase and ... | 1984 | 6088170 |
| perinatal development of the lung in rat and spiny mouse: its relation to altricial and precocial timing of birth. | rat and spiny mouse (acomys cahirinus) are closely related murinoid species that represent altricial (rat) and precocial (spiny mouse) modes of development. the late intrauterine developmental stages of the spiny mouse therefore seem comparable to the early extrauterine developmental stages of the rat. to elucidate the question to what extent the development of the lung is related to the developmental timing of birth, we have studied some enzymes involved in the de novo synthesis of phosphatidyl ... | 1984 | 6326867 |
| paternal behavior in the spiny mouse (acomys cahirinus). | the responsiveness of adult male spiny mice (acomys cahirinus) to both their own and alien precocial young was investigated. paternal behavior was manifested primarily by the males huddling with their offspring and the coordination of pup attendance between adult males and females. with less than 2 days exposure to their own neonates, males were found to discriminate between their own and alien young. experience plays an important role in the development of paternal behavior in spiny mice. males ... | 1984 | 6487216 |
| chromosomal phylogeny of muridae: a study of 10 genera. | the karyotypes of 10 different species of the family muridae (acomys airensis, arvicanthis niloticus, hylomyscus stella, malacomys longipes, mastomys huberti, myomys daltoni, mus musculus, rattus norvegicus, thamnomys gazellae, and uranomys ruddi) are compared by different banding techniques. from a reconstruction of the presumed ancestral karyotype of the muridae the sequence of the various rearrangements leading to the present karyotypes is proposed in order to determine their phylogenetic rel ... | 1983 | 6617265 |
| archicortex and neocortex in the precocial murid acomys cahirinus. a comparison with two altricial species: mus musculus and rattus norvegicus. | a morphological analysis of some structures of the archicortex and neocortex was performed in the acomys cahirinus (spiny mouse), the only precocial murid. the data obtained indicate that the spiny mouse brain is an interesting case of a largely developed hippocampus with respect to the neocortex when compared to the brains of the mouse and rat. the precocious pups of the spiny mouse present the peculiarity among murids of an early olfactory imprinting. | 1983 | 6668122 |
| hippocampal maturation in the precocial murid rodent acomys cahirinus. | growth rates in the dentate gyrus and hippocampus proper of the precocial murid acomys cahirinus were examined by measuring age-related changes in laminar volume in 0-, 10-, 20-, and 60-day postpartum animals. a biphasic course of maturation was observed in both structures, with rapid expansion occurring in the first 10 postnatal days and more gradual growth thereafter. this pattern of growth resembles those reported for newborn altricial murids such as the laboratory mouse and rat. however, due ... | 1984 | 6713169 |
| brain acetylcholinesterase and its molecular forms in a precocial murid, acomys cahirinus, and rat during post-natal development. | brain acetylcholinesterase (ache) and its molecular forms of a precocial murid, acomys cahirinus, characterized by a large hippocampus, were measured during post-natal development and compared with rat. the activity of soluble ache in acomys increased slightly up to 4 weeks after birth. the total ache activity increased somewhat more but, in rats, this increase was still greater. three main molecular forms of ache were separated by 7.5% polyacrylamide gel electrophoresis. their close similarity ... | 1984 | 6720191 |
| delayed or biphasic glucose-induced insulin secretion of pancreatic islets isolated from spiny mice (acomys cahirinus) : relation to age of animals. | the dynamics of insulin release from spiny mouse perifused pancreatic islets was investigated. in agreement with earlier studies we found no initial (0-10 min) insulin secretion in response to glucose in islets prepared from mice up to 35 weeks of age. the islets of animals older than 40 weeks, however, were characterized by greater insulin content, and a restored typical biphasic insulin secretion profile. the results suggest that immediate glucose response is modified by environmental or other ... | 1980 | 6989661 |
| accumulation of pancreas-specific products during organogenesis of acomys cahirinus. | | 1980 | 6997134 |
| comparison of insulin secretion by the isolated perfused pancreas and perifused islets of the spiny mouse (acomys cahirinus). | the dynamics of glucose-stimulated insulin release were studied in the perfused pancreas and in isolated perifused islets of spiny mice. the pattern of insulin release induced by an increase of the glucose concentration from 2.8 mm to 16.7 mm was different in the two preparations. in the perfused pancreas there was an early insulin release contrasting with an absence of the early response in isolated islets. the later insulin release response (5 min to 30 min) was present and similar in both pre ... | 1981 | 7020305 |
| intermediary metabolism during the development of obesity and diabetes in the desert rodent acomys cahirinus. | the spiny mouse acomys cahirinus, which exhibits beta-cell hyperplasia but low insulin secretion in captivity responded with hyperlipidemia without obesity or diabetes on a sucrose diet and became obese, and glucose-intolerant on a diet of fat-rich seeds. a three-month sucrose diet induced a marked rise in the activity of regulatory enzymes of glycolysis and lipogenesis in the liver but not in adipose tissue. there was also increased energy waste on this diet evident from a three-fold rise in th ... | 1982 | 7118367 |
| the oestrous cycle of the spiny mouse (acomys cahirinus). | the oestrous cycle of the spiny mouse (acomys cahirinus), as determined by vaginal smears, is 11.1 +/- 1.9 (s.d.) days (n = 110). the vaginal smears show cell patterns similar to those seen in the rat, but secretion of mucus is greater than in the rat. the average age at vaginal opening is 45 +/- 2.77 (s.e.m.) days, but the first litter (sired by litter mates) did not occur until 103 +/- 4.04 (s.e.m.) days. the decidual response to uterine trauma indicates tha there is an active luteal phase. th ... | 1981 | 7193735 |
| the response of the egyptian spiny mouse (acomys cahirinus) and two other species of commensal rodents to anticoagulant rodenticides. | the response of acomys cahirinus to three anticoagulant rodenticides was investigated in the laboratory. in contrast to the other commensal rodents rattus rattus and r. norvegicus, this species appears to be naturally very resistant to warfarin, difenacoum and brodifacoum. it is considered unlikely that anticoagulant poisons would be effective in the field for the control of a. cahirinus. | 1981 | 7240734 |
| experiential influences on the development of huddling preferences and "sibling" recognition in spiny mice. | the role of experience in the development of huddling preferences and sibling recognition by spiny mouse (acomys cahirinus) weanlings was investigated. in the 1st experiment, pups separated from their littermates and fostered onto unfamiliar females (and their offspring) on the day of birth, day 10, or day 20, subsequently showed preferential huddling with their foster littermates. huddling by biological siblings was as infrequent as huddling by unrelated, unfamiliar agemates. the 2nd study reve ... | 1981 | 7250526 |
| development of the adult pelage in normal and hormone-injected spiny mice (acomys cahirinus). | the dorsal pelage of the adult egyptian spiny mouse (acomys cahirinus) consists primarily of coarse brittle spines which differ from those of the juvenile pelage. the development of the adult pelage in juvenile spiny mice was examined in normal and estradiol- or testosterone-injected animals. females complete the development of their adult pelage significantly faster than males. both estradiol and testosterone injections speed pelage development in males. testosterone causes a significant delay ... | 1981 | 7338723 |
| interaction between acari ectoparasites and rodents in suez governorate, egypt. | from the medical point of view, the relation between man and rodents comes in the priority. some rodent populations are wild but others are commensal and live in close association with man. they steal his food and conveying many zoonotic diseases. their arthropod ectoparasites play an important role in conveying or transmitting these zoonotic diseases. several disorders and diseases of man are tick borne relapsing fever, rocky mountain spotted fever, lyme disease, and many others. besides numero ... | 1995 | 7665934 |
| biotransformation in egyptian spiny mouse acomys cahirinus. | the activities of several representative biotransformation enzymes were determined in male and female spiny mouse tissues. cytochrome p450 monooxygenase activity toward benzo(a)pyrene was significantly greater in female spiny mouse intestine than in males. activity toward benzphetamine in both sexes was high in the liver, with little activity in the kidney and intestine. sulfotransferase activity was high in kidney and intestine of female spiny mice but undetectable in the same tissues in males. ... | 1995 | 7749597 |
| organ-to-body weight ratio in the egyptian spiny mouse acomys cahirinus. | | 1994 | 7933979 |
| ultrastructure of kolmer's crystalloid in the pinealocytes of the common spiny mouse (acomys cahirinus dimidiatus). | light- and electron-microscopical observations revealed a rod-like inclusion body in the pinealocytes of the common spiny mouse (acomys cahirinus dimidiatus). ultrastructurally, the body is composed of a varying number of tubes whose wall consists of thin filaments aligned in helical arrangement. the inner and outer surface of the wall is covered with ribosome-like granules. based on a morphological analysis it is concluded that the body described in the present investigation is identical with k ... | 1993 | 8269483 |
| daily rhythms of body temperature in acomys russatus: the response to chemical signals released by acomys cahirinus. | two species of spiny mice of the genus acomys--the golden spiny a. russatus and the common spiny a. cahirinus--are sympatric in the arid and hot parts of the rift valley in israel. the coexistence of these two species is due to exclusion of a. russatus mice by a. cahirinus mice from nocturnal activity. the aim of this research was to study if odor signals released by a. cahirinus mice can play a role in the exclusion of a. russatus mice. a. russatus mice with an implanted transmitter recording b ... | 1993 | 8319316 |
| larval occurrence of hydatigera taeniaeformis batsch (1786) (cestoda: taeniidae) in the liver of wild rodents in egypt. | hydatigera taeniaeformis batsch (1786) was found in the liver of six species of egyptian wild rodents. wanas et al., (1990) found the total incidence of this larval stage to be 20.0% among cestode infection. it was found in (40.9%) rattus norvegicus; (33.3%) gerbillus gerbillus; (26.8%) rattus rattus; (25.0%) mus musculus; (16.6%) acomys cahirinus; and (7.2%) arvicanthis niloticus. the cysts of hydatigera taenioformis was always occupying the marginal surfaces of both right and left lobes and so ... | 1993 | 8376855 |
| stability of preference for odors after short-term exposure in young spiny mice. | the stability of olfactory preferences for artificial odors was studied in young spiny mouse pups (acomys cahirinus). subjects aged between 2 and 20 days were exposed to the odor of either cinnamon or cumin for 1.5 hr. the durability of preferences for the familiar versus novel odor was subsequently monitored in a three-choice preference test. the results suggest the existence of a sensitive phase for learning odor characteristics, through simple exposure, between days 2 and 18 of the pups' post ... | 1993 | 8440404 |
| the cairo spiny mouse acomys cahirinus shows a strong affinity to the mongolian gerbil meriones unguiculatus. | the classification of the african spiny mice (genus acomys) within the muridae family of rodents has been fraught with controversy. morphological data suggest a close affinity between this group and true old world mice of the genus mus. however, the combined results of immunological, biochemical, and dna melting studies suggest that spiny mice should not even be considered as members of the murinae subfamily. to further elucidate the position of the spiny mice within the rodent phylogenetic tree ... | 1996 | 8583903 |
| development and consequences of insulin resistance: lessons from animals with hyperinsulinaemia. | studies involving genetically and nutritionally induced diabetes in animals indicate that early hyperinsulinaemia is the causative factor of tissue insulin resistance, leading to compensatory insulin oversecretion and pancreatic beta-cell dysfunction. the models for this syndrome, which occurs in association with obesity (thus termed "diabesity" here), concern either species with a sturdy pancreas, capable of long-lasting oversecretion, or those with labile beta cells which cannot sustain the in ... | 1996 | 8792092 |
| respiratory rhythm generation in a precocial rodent in vitro preparation. | in vitro preparations for studying the neural control of respiration consisting of brainstem and spinal cord regions isolated from the newborn (po-p1) precocial rodent, acomys cahirinus (spiny mouse) are described. spiny mice have a longer gestation period (39 days) than laboratory rats (22 days) and mice (20 days) and thus are born in a considerably more mature state. we sought to determine if in vitro preparations isolated from spiny mice would spontaneously generate a respiratory motor patter ... | 1996 | 8833542 |
| effect of passage of babesia ovis in the gerbil (acomys cahirinus) on the course of infection in splenectomized lambs. | splenectomized gerbils (acomys cahirinus) have been found to be susceptible to babesia ovis applied via blood inoculation, whereas intact gerbils were not infected. blood from splenectomized latently infected gerbils caused infection in a splenectomized lamb. intact acomys cahirinus gerbils did not become infected by b. ovis, and all captured rodents in an enzootic area, intact and splenectomized, were found to be negative for b. ovis. it can thus be concluded that acomys cahirinus does not serv ... | 1996 | 8916410 |
| a new coccidian from acomys cahirinus desmarest, 1819, from evolution canyon, lower nahal oren, mount carmel, israel. | in 1994, fresh fecal samples were collected and examined for coccidian parasites from 43 spiny mice (acomys cahirinus) and from 60 wood mice (apodemus mystacinus). the 2 genera of rodents inhabit an area in lower nahal oren. mount carmel, israel, known as evolution canyon, which consists of opposite-facing slopes that are geologically identical, but micro-climatically very different. acomys cahirinus is found primarily on the warmer and drier south-facing slope (sfs), whereas a. mystacinus prima ... | 1997 | 9105310 |
| histology and enzymatic activity in the postnatal development of limb muscles in rodents. | the present work examines how increases in spontaneous motor capabilities during postnatal development are reflected in enzymatic activity and the histology of hindlimb muscles of the dormouse (eliomys melanurus), the jird (meriones tristrami), the vole (microtus socialis), and the spiny mouse (acomys cahirinus). the precocial neonate of the spiny mouse had the most advanced developmental state of young myofibers with striations as early as 1 week after delivery. at the same age, the altricial n ... | 1998 | 9523911 |