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haemaphysalis (allophysalis) danieli, sp. n. (ixodoidea: ixodidae), female and tentatively associated immature stages from high mountains of northern pakistan and afghanistan.haemaphysalis (allophysalis) danieli sp. n. is described from a female taken from alpine vegetation in swat, pakistan. fifty-one nymphal and larval ticks tentatively associated with this taxon are from hamsters, field mice, voles, and marmots (rodentia), cricetulus migratorius, apodemus flavicollis, alticola roylei, and marmota caudata, and from pikas (lagomorpha), ochotona roylei, in gilgit and hazara districts of pakistan and in badakhashan province of afghanistan. collecting localities are in ...1977864574
comparative investigation of cyclophosphamide action on bone marrow cells of the armenian hamster and 4 other species of rodents.we studied the clastogenic action of cyclophosphamide (cp) on bone marrow cells of the armenian hamster (ah), cricetulus migratorius. cp induced a dose-dependent linear increase in aberrant cells. the maximal cytogenetic action was observed 12 h after cp treatment. male and female ahs were similarly sensitive to the clastogenic action of cp. we compared cp clastogenicity at a dose of 25 mg/kg on bone marrow cells of ahs, mice, rats, guinea pigs and chinese hamsters 24 h after treatment. we obser ...19921379326
isolation and initial characterization of a large repeat sequence element specific to mouse chromosome 8.a clone containing 15.6 kb of mouse genomic dna was specifically localized to murine chromosome 8 by fluorescence in situ hybridization. the major signal, mapping just below the centromeric heterochromatin, was much too intense for a single-copy probe. two additional weak hybridization signals were detected in or near distal bands 8b3 and 8d. six subclones spanning the entire 15.6-kb insert gave strong centromere proximal signals; however, none of these clones cross-hybridized with each other, s ...19921559702
generation and characterization of hamster-mouse hybridomas secreting monoclonal antibodies with specificity for lipopolysaccharide receptor.experiments are described for the partial purification of the 80-kda lps binding protein expressed on macrophages and lymphocytes. this partially purified ag was used to immunize adult armenian hamsters and splenocytes from immunized animals were fused with murine myeloma cell lines. hybridoma cell culture supernatants containing mab were screened by elisa for positive binding to the immunizing ag, murine splenocytes and the murine 70z/3 pre b cell and for an absence of binding to sheep e. posit ...19901694199
[harvest mites of the family trombiculidae in the steppe zone of the southeastern ukraine].virgin and cultivated biotopes of the sea of azov area of donetsk province were investigated for parasite coenoses of small mammals. 469 animals and 210 nests were collected, apodemus sylvaticus, mus musculus, microtus arvalis and cricetulus migratorius being the most abundant species. in all 2940 larvae of trombiculids (18 species) were found on animals and in their nests (2846 specimens on animals and 94 specimens in nests). two species, hoffmannina theodori and doloisia skljari, are new for s ...19892717200
[cytogenetic characteristics of 2 new transplantable cell lines of the gray hamster (cricetulus migratorius) transformed by rous sarcoma virus]. 19714331866
[tumor induction in grey (armenian) hamsters by the sv40 virus]. 19724350872
[possibility of rous sarcoma virus reproduction in an in vitro transformed cell line from the embryo of the armenian hamster cricetulus migratorius pal.)]. 19744373925
[biology and normal karyotype of the gray hamster (cricetulus migratorius vernula thom)]. 19705457179
[breeding the gray armenian hamster (cricetulus migratorius, pall) under laboratory conditions]. 19675634225
isomorphic sex chromosomes, autosomal heteromorphism, and telomeric associations in the grey hamster of armenia, cricetulus migratorius, pall. 19655826651
diethylstilbestrol-induced jaundice in the chinese and armenian hamster.an unusual and impressive hyperbilirubinemia was induced in chinese hamsters by administration of diethylstilbestrol (des). this icterus was dose-dependent and affected females more severely than males. however, a similar mortality was detected in both sexes. another hamster, the armenian hamster, was even more susceptible to the icteric and lethal effects of des. the hamster model of des-induced icterus showed many clinical dissimilarities when compared to the human estrogen-induced jaundice, s ...19836602753
stable hamster-mouse hybridomas producing igg and igm hamster monoclonal antibodies of defined specificity.specific antibody-secreting hybridomas have been obtained by fusing syrian or armenian hamster (mesocricetus auratus or cricetulus migratorius) spleen cells with mouse myeloma cells. the hamsters were immunized to mouse cytolytic t lymphocytes. hybrids were selected either by an indirect binding assay using an 125i-monoclonal antibody (mab) reactive with hamster kappa-chains or by their ability to block t cell-mediated cytolysis. three hybridoma clones were obtained that secreted intact igm-like ...19836847883
an anti-idiotype antibody which mimics the inner-core region of lipopolysaccharide protects mice against a lethal challenge with endotoxin.recently, we described the generation and characterization of an armenian hamster ab2 beta anti-idiotype monoclonal antibody (mab4g2) specific for the binding site of a mouse monoclonal antibody, maby1-4a6, directed against the conserved 2-keto-3-deoxyoctulosonate (kdo)-containing inner-core region of lipopolysaccharide (lps) (s. k. field, m. pollack, and d. c. morrison, microb. pathog. 15:103-120, 1993). in that study, mice and hamster immunized with mab4g2 generated serum immunoglobulin g and ...19948063418
identification of pseudocysts of tritrichomonas muris in armenian hamsters and their transmission to mice. 199910403448
demodex cricetuli: new species of hair follicle mite (acari: demodecidae) from the armenian hamster, cricetulus migratorius (rodentia: cricetidae).demodex cricetuli sp. nov. is described, in all life stages, from the armenian hamster, cricetulus migratorius. this demodecid inhabits the hair follicles of all body regions of the host. heavy infestations are associated with dermatitis and alopecia. demodex cricetuli is most similar to d. aurati, from the golden hamster, but adults differ in podosomal length, shape of the opisthosomal terminus, genital opening and opisthosomal organ of the male, and overall length-to-width ratios.19947932598
generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.mab to murine tnf (mutnf) were produced after immunization of armenian hamsters with purified, escherichia coli-derived rmutnf-alpha. antibody produced from clone tn3-19.12, was purified and was found to inhibit 100% of the lytic activity of either recombinant or natural mutnf-alpha at an antibody input of 25 ng/u. tn3-19.12 also inhibited all the lytic activity in culture supernatants from a variety of t cell sources, including activated t cell clones and t cell hybridomas (all of which express ...19892469726
[comparative observation on experimental infection with echinococcus multilocularis in cricetulus migratorius and meriones meridianus].to search for an animal model with higher susceptibility to echinococcus multilocularis and shorter experimental period.199812078223
sex hormones and tumor promotion in liver.epidemiological and experimental data strongly support a causal relationship between exposure to excessive levels of estrogens and the development of cancer in various tissues. in this paper, we have presented background information that shows a correlation between the prolonged use of oral contraceptives and the development of liver cancer. the clinical data supported the hypothesis that the estrogenic components of oral contraceptives were promoters of hepatocarcinogenesis, and the experimenta ...19911924403
bromodeoxyuridine tablet methodology for in vivo studies of dna synthesis.5-bromodeoxyuridine (brdu) tablets with different physical characteristics are useful in a wide variety of studies requiring detection of dna replication in vivo. these tablets can effect a high substitution of brdu in dna, thereby permitting sister chromatid differentiation in chromosomes stained with 33258 hoechst alone or in conjunction with giemsa. baseline and cyclophosphamide-induced in vivo sister chromatid exchange frequencies in mouse spleen, marrow, and thymus were measured and found t ...1978356290
[sensitivity of normal and rous virus-transformed lines of armenian hamster cells to infectious viruses].the capacity of normal (nhet) and rous virus-transformed cell line of armenian hamster both producing (shet sh-r) and not producing (shet k-3) virus to support reproduction of vaccinia and newcastle disease viruses was demonstrated. the former of these viruses replicated in the cell cultures with cytopathic effect, the latter did so without causing cell degeneration. the degree of newcastle disease virus reproduction in all 3 cultures was the same whereas vaccinia virus synthesis in shet sh-r wa ...1975176825
serum amyloid-p component of the armenian hamster: gene structure and comparison with structure and expression of the sap gene from syrian hamster.serum amyloid p (sap), a phylogenetically conserved pentraxin, is an integral component of all amyloid deposits. regulation of expression of sap gene expression is quite different in two related hamster species. in syrian hamsters, the resting serum levels of sap are determined by gender, and the direction of alteration following inflammation is divergent. in armenian hamsters, sap is not a prominent acute-phase reactant and there is no gender dimorphism of expression. the structure and expressi ...19938235447
effect of hamster pregnancy on female protein, a homolog of serum amyloid p component.pentraxins such as human serum amyloid p component (sap) and c reactive protein (crp) represent an ancient family of proteins that are ubiquitous in nature and have evolved with little change in structure or regulation. the pentraxin in the syrian hamster (mesocricetus auratus) is unique because it is preferentially expressed in the female at high constitutive levels and accordingly called female protein (fp) or fp(sap) due to its close homology with human sap. the high levels of fp in female se ...199910460699
vectors and reservoirs of cutaneous leishmaniasis in marvdasht district, southern islamic republic of iran.an epidemiological study was made of vectors and reservoirs of cutaneous leishmaniasis in rural regions of marvdasht, fars province, southern islamic republic of iran during 2003-04. using live traps, 126 rodents were collected: 75.4% were meriones libycus, 14.3% cricetulus migratorius and 10.3% microtus arvalis. eight out of 95 meriones libycus (8.4%) were found to be infected with leishmania major, identified by nested-pcr; none of the other rodents were positive. female sandflies were collect ...200717687843
gamasine mite (parasitiformes: mesostigmata) infestations of small mammals (mammalia: rodentia, insectivora) in turkey.the present study was conducted on small mammals from different locations in turkey. one hundred twenty- three individuals representing 11 species of rodents and insectivora were investigated for mite ectoparasites. a total of 126 gamasine mites were collected from 96 individuals (78.1%) of 6 species of small mammals. five gamasine families were recorded: laelapidae, hirstionyssidae, haemogamasidae, macronyssidae and macrochelidae. laelaps jettmari vitzthum (72 species) was predominant and found ...200818351555
preparation of monoclonal antibodies to murine platelet glycoprotein iib/iiia (alphaiibbeta3) and other proteins from hamster-mouse interspecies hybridomas.to obtain mouse-specific monoclonal antibodies (mabs) against platelet proteins, an armenian hamster was immunized with washed mouse platelets. immune splenocytes were then fused with a nonsecreting murine myeloma cell line, and the resulting heterohybridomas were screened for antibody production utilizing an elisa in which the target antigen was mouse platelets adsorbed onto microtiter plates in the presence of thrombin. secondary screening assays included elisa tests using murine fibrinogen or ...199910448087
armenian hamster female protein (serum amyloid p component). comparison with the sex-regulated homolog in syrian hamster.complementary dna clones for armenian hamster female protein (fp) were isolated and the complete nucleotide sequence and derived amino acid sequence were determined and compared with relevant data for the closely related syrian hamster. although biosynthesis of presap is directed by a 1.0-kb mrna in both genera and the molecular mass of the primary translation product of fp is identical, the fp gene structure and regulation of expression of fp are different in syrian and armenian hamsters. where ...19892479691
induction of thyroid-stimulating hormone receptor autoimmunity in hamsters.female chinese hamsters (n = 10) were immunized with chinese hamster ovary (cho) cells that expressed the human tsh receptor (tshr) to generate a model of graves' disease. tshr-autoantibodies (tshr-ab) were determined by cho-tshr. two hamsters with stimulating tshr-ab showed thyrocyte hypertrophy associated with a focal lymphocytic infiltration. cho-tshr were then stimulated with interferon gamma to enhance major histocompatibility complex class ii expression. however, after immunization no stim ...200312538630
helminth infections of meriones persicus (persian jird), mus musculus (house mice) and cricetulus migratorius (grey hamster): a cross-sectional study in meshkin-shahr district, northwest iran.rodents have important role as reservoirs of different parasites. the aim of this study was to determine helminth parasites of abundant rodents in meshkin-shahr, ardabil province northwest iran.201728096855
mitochondrial genome of cricetulus migratorius (rodentia: cricetidae): insights into the characteristics of the mitochondrial genome and the phylogenetic relationships of cricetulus species.cricetulus migratorius is widely distributed in the northwestern arid regions of china. here, the complete mitochondrial genome (mitogenome) of c. migratorius is reported, to our knowledge, for the first time. it was found to be 16,246bp in length, including 13 protein-coding genes (pcgs), 2 rrna genes, 22 trna genes, and one control region, and showed characteristics typical of the vertebrate mitogenome. comparative analyses of mitogenomes of cricetulus species showed that hamster mitogenomes h ...201627717890
hamster female protein, a pentameric oligomer capable of reassociation and hybrid formation.syrian hamster female protein (sfp), a serum oligomer composed of five identical subunits, was reassociated in vitro from monomer subunits. the reconstituted pentamer was genuine by morphologic, antigenic, and structural criteria. another female protein (fp), a homologue from armenian hamsters (afp), also reassociated into a pentamer after dissociation with 5 m guanidine hydrochloride. these two fp's hybridized when a mixture of them was dissociated and then reassociated. differences between the ...19872436652
tamoxifen prevents induction of hepatic neoplasia by zeranol, an estrogenic food contaminant.zeranol (alpha-zearalanol) is a beta-resorcylic acid lactone (ral) that has estrogen activity. it is synthesized by molds and is difficult to avoid in human food products. we tested the ability of this mycoestrogen to damage the liver of the armenian hamster, a rodent that is especially sensitive to hepatotoxic effects of exogenous estrogens. zeranol induced acute hepatotoxicity and, subsequently, hepatic carcinogenesis; both effects were blocked by tamoxifen, suggesting estrogen receptor mediat ...19921736291
armenian hamster female protein: a pentraxin under complex regulation.the serum of armenian hamster (cricetulus migratorius) contains a protein homologous to female protein (fp) that has been characterized in the syrian (golden) hamster. of unknown function, fp belongs to a family of proteins (called pentraxins) that have a common ancestral gene and are widely expressed in nature. whereas serum concentration of fp in syrian hamsters (sfp) is many fold greater (200- to 300-fold) in females vs. males, armenian hamster fp (afp) is only moderately elevated (approximat ...19901696791
characterization of h4: a mouse t lymphocyte activation molecule functionally associated with the cd3/t cell receptor.the monoclonal antibody c398.4a was produced by immunizing armenian hamsters with the mouse t cell clone d10.g4.1. it recognizes a molecule selectively expressed by activated mouse t cells and was named h4. h4 is expressed on the t cell surface about 24 h after activation and peaks at day 7. by contrast, it is not expressed by resting or activated b cells, macrophages, or fibroblasts. it is also expressed by cd4 or cd8 single-positive mature thymocytes. immunoprecipitation showed that h4 is a di ...19968921969
demodex microti n. sp. (acari: demodecidae) in microtus arvalis (pallas) (rodentia, cricetidae) with a checklist of the demodecid mites of cricetids.demodex microti n. sp. (acari, demodecidae) is described from the skin of the genital area of the common vole microtus arvalis (pallas) in poland based on the morphology of the adult and immature stages. the new species appears most similar to d. cricetuli hurley & desch, 1994 from the gray dwarf hamster, cricetulus migratorius (pallas), but differs in the following features: the supracoxal spines are conical and located at the edge of the gnathosoma, the spines of the terminal segment of palp a ...201324048750
cloning of a hamster anti-mouse cd79b antibody sequences and identification of a new hamster immunoglobulin lambda constant iglc gene region.anti-cd79 antibodies have been effective at targeting b cell lymphoma cells and depleting b cells in animal models. in order to engineer recombinant antibodies with additional effector functions in mice, we cloned and sequenced the full-length cdnas of the heavy and light chain of a hamster anti-mouse cd79b antibody. although hamster antibodies represent a unique source of monoclonal antibodies against mouse, rat, and human antigens, sequence information of hamster immunoglobulins (ig) is sparse ...201323558558
syrian and armenian hamsters differ in serum amyloid a gene expression. identification of novel syrian hamster serum amyloid a subtypes.amyloid a (aa) amyloidosis is widespread throughout the animal kingdom. several factors including: 1) precursor production; 2) precursor structure; 3) precursor degradation; and 4) precursor/product interaction with the pentraxin serum amyloid p have been implicated in amyloidogenesis, but the exact sequence of events leading to aa fibril formation and deposition remains unclear. most models of experimental amyloidosis, including golden syrian hamsters (mesocricetus auratus), involve massive and ...19938515064
a "hot spot" of recombination coincides with an interstitial telomeric sequence in the armenian hamster.the chromosomes of male armenian hamsters (cricetulus migratorius) exhibit highly localized terminal and interstitial chiasmata. an interstitial telomeric sequence detected by in situ hybridization was clearly visible at the primary constriction of a large metacentric in both mitotic and meiotic chromosomes. this telomeric sequence was the site of a chiasma in 69% of all 58 diakinesis/metaphase i cells examined. the frequency of meiotic exchange at this site was therefore 34.5%, an extraordinary ...19938428518
monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75.monoclonal antibodies (mabs) specific for the murine p55 and p75 tumor necrosis factor (tnf) receptors were produced after immunization of armenian hamsters with the purified soluble extracellular domains of each receptor protein. four p55- (55r) and five p75 (tr75)-reactive mabs immunoprecipitated the appropriate receptor from the surface of l929 cells. none of the mabs cross-reacted with the other tnf receptor form. the mabs were functionally characterized by their ability to inhibit ligand bi ...19957836916
preparation of specific antibodies against murine il-1ra and the establishment of il-1ra as an endogenous regulator of bacteria-induced fulminant hepatitis in mice.blocking monoclonal antibodies (mabs) specific to mouse interleukin-1 receptor antagonist (il-1ra) were prepared by immunizing armenian hamsters with recombinant mouse il-1ra. a sensitive and specific elisa against mouse il-1ra was also established. in propionibacterium acnes-induced liver injury, p. acnes induced transient increase of serum tumor necrosis factor-alpha levels but not those of il-1ra, il-1, and il-6. however, subsequent lipopolysaccharide (lps) challenge induced the increase of s ...19957616110
observations on the synaptonemal complex in armenian hamster spermatocytes by light microscopy.using the silver staining technique, in somatic and meiotic chromosomes of the armenian hamster (cricetulus migratorius), it is possible to stain synaptonemal complexes (scs) and the nucleolus organizer regions (nors) in early spermatocytes. there are five pairs of autosomes (nos. 2, 4, 6, 7, and 8) which have terminally located nors. synaptonemal complexes and accessory structures present in the sex chromosomes within the sex vesicle can be easily observed using light microscopy.200190589
dissecting linear and conformational epitopes on the native thyrotropin receptor.the tsh receptor (tshr) is the primary antigen in graves' disease. in this condition, autoantibodies to the tshr that have intrinsic thyroid-stimulating activity develop. we studied the epitopes on the native tshr using polyclonal antisera and monoclonal antibodies (mabs) derived from an armenian hamster model of graves' disease. of 14 hamster mabs analyzed, five were shown to bind to conformational epitopes including one mab with potent thyroid-stimulating activity. overlapping conformational e ...200415297445
generation of functional blocking monoclonal antibodies against mouse interleukin-12 p40 homodimer and monomer.the role of interleukin (il)-12 (p40:p35) and il-23 (p40:p19) is becoming clear in immune response and inflammation. however, biological functions of il-12 p40 homodimer (p40(2)) and monomer (p40) remain poorly understood due to the lack of specific monoclonal antibodies (mab). earlier we have demonstrated that both p40(2) and p40 activate microglia and macrophages to induce the expression of inos and tnf-alpha. to facilitate the studies on p40(2) and p40 further, we here describe the production ...200818582206
comparison of the mrna sequences for pi class glutathione transferases in different hamster species and the corresponding enzyme activities with anti-benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide.glutathione s-transferase (gst) of class pi (gst pi) is known to detoxify the mutagenic and carcinogenic (+)-anti-benzo[a]pyrene-7, 8-dihydrodiol 9,10-epoxide [(+)-anti-bpde] by conjugation with glutathione. previously, we have shown that chinese hamster v79 cells contain gst pi, but seem to lack the capacity to conjugate (+)-anti-bpde, although these cells do conjugate other substrates with gsh [romert, dock, jenssen and jernström (1989) carcinogenesis 10, 1701-1707; swedmark, romert, morgenste ...19968809043
novel monoclonal antibody reactive with thrombin-sensitive 74-kda glycoproteins present on platelets and megakaryocytes both from mouse and rat.a monoclonal antibody (designated 1c2) that reacts only with mouse platelets and megakaryocytes among hematopoietic cells was established by immunizing mouse platelets to an armenian hamster. 1c2 reactive mouse molecule (1c2 antigen) was a surface glycoprotein with molecular weight of 74 kda. side by side comparison revealed that 4a5, a rat monoclonal antibody against mouse platelet, immunoprecipitated the identical molecule to 1c2 antigen. of particular interest, 1c2 also labeled rat tissues wi ...19958522348
ticks (acari: ixodidae) infesting some small mammals from northern turkey with new tick-host associations and locality records.ticks are obligate ectoparasites of a vast range of terrestrial vertebrates which may play an important role in the transmission of many zoonotic pathogens to humans and animals. in the current study, we performed an investigation on ticks infesting some small mammals captured from samsun and tokat provinces, northern turkey. one hundred forty-five mammalian samples belonging to four species, namely cricetulus migratorius (n = 1), apodemus flavicollis (n = 17), crocidura suaveolens (n = 102) and ...201729110169
wild rodent ectoparasites collected from northwestern iran.rodents play an important role as reservoir of some pathogens, and the host of some ectoparasites as well. these ectoparasites can transmit rodents' pathogens to human or animals. the aim of this study was to assess the distribution and infestation load of ectoparasites on rodents in meshkin-shahr district, northwestern iran.201729026851
development of an anti-idiotype monoclonal antibody mimicking the structure of lipopolysaccharide (lps) inner-core determinants.an anti-idiotype antibody has been developed which is specific for idiotypic determinants of a balb/c mouse igg3 monoclonal antibody (maby1-4a6) directed against the inner-core kdo region of lipopolysaccharide (lps). armenian hamsters were immunized with maby1-4a6 and splenocytes from immunized animals fused with sp2/0 myeloma cells. eight clones secreting antibodies that bound to maby1-4a6, but not control igg3, were identified and subcloned. culture supernatants from one hybridoma, termed mab4 ...19938255205
transmission and adaptation of chronic wasting disease to hamsters and transgenic mice: evidence for strains.in vitro screening using the cell-free prion protein conversion system indicated that certain rodents may be susceptible to chronic wasting disease (cwd). therefore, cwd isolates from mule deer, white-tailed deer, and elk were inoculated intracerebrally into various rodent species to assess the rodents' susceptibility and to develop new rodent models of cwd. the species inoculated were syrian golden, djungarian, chinese, siberian, and armenian hamsters, transgenic mice expressing the syrian gold ...200717287284
apolipoprotein e is found in astrocytes but not in microglia in the normal mouse brain.apolipoprotein e (apoe) is a known risk factor for alzheimer's disease, but neither its roles in the pathogenesis nor its exact physiological functions in the brain is known. in order to study the apoe protein in the brains of normal mouse and transgenic mouse models of neurodegeneration, hamster monoclonal antibodies (mabs) specific to mouse apoe were generated. n- and c-terminal fragments of mouse apoe protein were produced in e. coli as fusion proteins and used to immunize armenian hamsters. ...199910616916
characterization of a 50 kda surface membrane protein on thymic stromal cells as an important factor for early t cell development.we previously reported that the nude mouse-derived splenic t cell clone, n-9f, exhibits a proliferative response to the sl10.3 thymic epithelial cell clone. in the present study we generated an armenian hamster mab, hs9, specific for sl10.3, which inhibited the n-9f's proliferative response to sl10.3. we performed thymocyte repopulation experiments using fetal liver cells and 2'-deoxyguanosine-treated thymic rudiments. after 14 days of culture, donor fetal liver cells proliferated and differenti ...19957547685
novel mabs reveal potent co-stimulatory activity of murine cd27.members of the tumor necrosis factor receptor (tnfr) family are emerging as important molecules implicated in the regulation of proliferation, differentiation and survival of t and b lymphocytes. among these receptors is cd27, the function of which has thus far only been studied in the human system, where it amplifies the t cell proliferative response induced by tcr triggering. we report here the generation of mabs to murine cd27, by an efficient method involving the use of transfected armenian ...19957547681
primary structures of three armenian hamster monoclonal antibodies specific for idiotopes and metatopes of the monoclonal anti-fluorescein antibody 4-4-20.this paper reports the complete v gamma, v kappa, c gamma 1 and c kappa nucleotide and deduced amino acid sequences of two hamster monoclonal anti-metatype antibodies, 3a5-1 and 4a6. these antibodies have been previously characterized in terms of their binding and molecular stabilization properties with liganded murine monoclonal and single-chain antibody 4-4-20 active sites. also reported are the complete v kappa and c kappa nucleotide and deduced amino acid sequence of hamster monoclonal anti- ...19958544859
a dominant epitope of hiv-1 protease recognized by hamster monoclonal antibodies.monoclonal antibodies (mabs) against hiv-1 protease (hiv pr), the essential protease of human immunodeficiency virus type 1 (hiv-1), were produced in armenian hamsters. studies of direct binding to synthetic peptides and inhibition of binding to intact protease by peptide competition showed that five mabs recognized an epitope that includes the sequence lpgrwkpk (residues 38-45), which lies near the region of the protease called the flap. all of the mabs react specifically with hiv pr in western ...19938496788
activation of wnt signaling in the intestinal mucosa of apc +/min mice does not cause overexpression of the receptor tyrosine kinase met.the receptor tyrosine kinase met is overexpressed in human colorectal adenomas and carcinomas, suggesting an instrumental role for met signaling in the onset and progression of colorectal cancer. to corroborate this role, animal models are needed. to study the expression of met in the normal and neoplastic mouse intestine, we generated an armenian hamster monoclonal antibody against mouse met. by using this antibody in immunohistochemical studies, we observed strong met expression in fetal mouse ...200616863504
the human egf-tm7 receptor emr3 is a marker for mature granulocytes.emr3 is a member of the epidermal growth factor-seven-transmembrane (egf-tm7) family of adhesion class tm7 receptors. this family also comprises cd97, emr1, emr2, and emr4. to characterize human emr3 at the protein level, we generated armenian hamster mab. using the mab 3d7, we here demonstrate that emr3, like other egf-tm7 receptors, is expressed at the cell surface as a heterodimeric molecule consisting of a long extracellular alpha-chain, which possesses at its n-terminus egf-like domains and ...200717108056
estrogen-induced hepatic toxicity and hepatic cancer: differences between two closely related hamster species.estrogen is known to affect hepatobiliary function; however, it is unusual for high serum levels of estrogen to actually result in clinically detectable hyperbilirubinemia. women affected by cholestatic jaundice during pregnancy share this genetic susceptibility with two cricetulus hamsters, the armenian hamster (cricetulus migratorius) and the chinese hamster (cricetulus griseus). nevertheless, the pathophysiologic process responsible for this estrogen induced icterus may be different in women ...19989831364
investigation of possible age effects on meiotic chromosomal recombination and segregation in armenian hamster spermatocytes.male armenian hamsters were evaluated for age effects upon meiotic recombination and aneuploidy incidence. primary spermatocytes from young and old animals revealed similar chiasma frequencies. the incidence of terminal-type chiasmata in sex bivalents was also measured and found to be unaffected by age. percentages of univalents and of hyperploid metaphase ii cells were evaluated by chromosome groups based upon individual chromosome morphologies. regardless of age, the larger dichiasmate chromos ...19854075847
generation and characterization of a novel anti-rat cd40l antibody with inhibitory activities in vitro and in vivo.the cd40-cd40l interaction plays a critical role in cell-mediated immune responses. blocking this interaction has been shown to be beneficial in the treatment of various diseases studied in murine models. although rats are widely used to test therapeutic strategies in several disease models, a monoclonal antibody (mab) to block the cd40-cd40l interaction in rats is not broadly available. in the present study we generated armenian hamster fibroblasts expressing rat cd40l and used these to generat ...200818384807
spermatogonial and meiotic chromosomes of the armenian hamster, cricetulus migratorius. 19704914507
angioimmunoblastic lymphadenopathy, immunoblastic sarcoma of b cells. animal model: autoimmune-prone inbred armenian hamster. 1978645818
[isolation and characteristics of the cell line from the grey (armenian) hamster embryo]. 19744460643
[investigation of an inbred line of grey armenian hamsters]. 19734785979
[normal values for the peripheral blood and bone marrow of the grey (armenian) hamster]. 19724661961
latent meiotic anomalies related to an ancestral exposure to a mutagenic agent.when urethan is administered to cytologically normal f(2) progeny descended from grandsires exposed to ethyl methanesulfonate, meiotic anomalies in the forms of site-specific x-chromosome deletions and bivalent associations are noted in spermatocytes of male armenian hamsters examined 6 and 8 days after treatment, respectively. these latent anomalies are initiated and retained in a premutated state for two generations after the ancestral exposure to ethyl methanesulfonate, the additional impetus ...19715547731
a survey on endoparasites in wild rodents of the jaz murian depression and adjacent areas, southeast of iran.in this survey, rodents and their endoparasites were investigated in the jaz murian depression and adjacent areas, southeast iran. in total, 146 specimens of rodents belong to 13 species were trapped. in general, 10 different genera of endoparasites including 11 species were collected. the endoparasites were identified as follows: (1) nematodes: trichuris muris, syphacia obvelata, labiostomum sp., labiostomum naimi, mastrophorus muris, aspicularis tetraptera and heligmosomoides skrjabini, physal ...201830538358
faunistic study of the rodents of north khorasan province, north east of iran, 2011-2013.rodents are one of the most important hosts for some zoonotic diseases and also act as a reservoir of some ectoparasites and endoparasites. they cause damage to the farms and inflict public health. the aim of this study was to investigate the faunal composition of rodent in north khorasan province, northeast of iran.201830123806
thermoregulatory responses of mesic and xeric rodent species to photoperiod manipulations.thermoregulatory mechanisms in rodents were found to respond to photoperiod manipulations. in desert adapted species, non-shivering thermogenesis nst-capacity (the ratio between the maximal vo2 response to noradrenaline injection and rmr, measured 1 degree c below the lower critical point) increased, as due to long scotophase acclimation. the aim of the present study is to compare the thermoregulatory responses of mesic rodents with those of desert ones, to photoperiod manipulations. heat produc ...19989773501
molecular phylogeny of the cricetinae subfamily based on the mitochondrial cytochrome b and 12s rrna genes and the nuclear vwf gene.despite some popularity of hamsters as pets and laboratory animals there is no reliable phylogeny of the subfamily cricetinae available so far. contradicting views exist not only about the actual number of species but also concerning the validity of several genera. we used partial dna sequences of two mitochondrial (cytochrome b, 12s rrna) and one partial nuclear gene (von willebrand factor exon 28) to provide a first gene tree of the cricetinae based on 15 taxa comprising six genera. according ...200616483801
autoradiographic patterns of chromosome replication in male and female cell derivatives of the armenian hamster (cricetulus migratorius). 19695810924
synaptonemal complex aberrations in the pseudoautosomal region of x, y chromosomes in irradiated hamsters.the effects of x-radiation, bleomycin and amsacrine (m-amsa) on the meiotic chromosomes of male armenian hamsters were determined by electron microscopic analysis of synaptonemal complex (sc) damage. pachytene stage cells were analyzed 5 or 6 days following their treatment at putative preleptotene-leptotene stages of meiosis. of the multiple types of sc aberrations observed to be significantly increased over control levels, lateral element breakage and synaptic anomalies were most prevalent. the ...19947523835
natural intestinal protozoa in rodents (rodentia: gerbillinae, murinae, cricetinae) in northwestern iran.majority of parasitic infections in rodents have zoonotic importance. this study aimed to determine the frequency and intensity of intestinal protozoa infections of rodents including meriones persicus, mus musculus and, cricetulus migratorius.201728979348
clastogenic action of thiotepa on bone marrow cells of the armenian hamster.thiotepa (tt) induced chromosomal aberrations in the bone marrow cells of the armenian hamster, cricetulus migratorius, in a dose-dependent manner. the maximal clastogenic action was observed 24 h after treatment with thiotepa. male and female armenian hamsters were similarly sensitive to the clastogenic action of thiotepa. the lowest effective concentration of thiotepa for armenian hamsters was 2.5 mg/kg b.w. (6.1% of the ld50). the results obtained and analysis of the literature data have show ...19947523922
elicitation of distinct populations of monoclonal antibodies specific for the variable domains of monoclonal anti-fluorescein antibody 4-4-20.armenian hamsters were immunized with non-liganded, partially liganded or affinity-labeled anti-fluorescein mab 4-4-20. seventeen hybridoma producing monoclonal anti-4-4-20 antibodies were characterized from chemically-mediated fusions of immune hamster lymphocytes with murine sp2/o-ag14 myeloma cells. distinct populations of anti-4-4-20 monoclonal antibodies were isolated from hamsters receiving immunizations with partially liganded mab 4-4-20 relative to those receiving affinity-labeled 4-4-20 ...19938350870
[sex chromosome behavior in meiosis in the gray hamster (cricetulus migratorius pallas, 1770)].the sequence of x and y chromosomes pairing at meiotic prophase in the armenian hamster cricetulus migratorius pall., 1770 gas been studied. the results of differential staining (c-, ag-nor) of mitotic chromosomes are presented. the rare case of interstitial synapsis of the sex chromosomes has been described. earlier it was established only for peromyscus sitkensis (hale, greenbaum, 1986). pairing of the x and y chromosomes is initiated at an interstitial position of the euchromatic region with ...19938370506
molecular characterization of calodium hepaticum in grey dwarf hamster (cricetulus migratorius).calodium hepaticum (bancroft, 1893) moravec, 1982 (syn. capillaria hepatica) is a zoonotic nematode that causes hepatic capillariosis, an uncommon zoonotic infection. the nematode is globally distributed and parasitizes the liver of mammals, mainly muroidea. cricetulus migratorius pallas, 1773 (cricetinae) was rarely reported as a host for c. hepaticum. in turkey, c. hepaticum was recorded in three rodent species; rattus rattus, r. norvegicus, and apodemus flavicollis. in this study, c. migrator ...202032407938
genetic characterization of the turkish gray hamster (cricetulus migratorius) based on mitochondrial cytochrome b and 12s rrna sequences.although genetic diversity and phylogenetic status of the gray hamster (cricetulus migratorius) have been investigated from different regions in previous studies, genetic data on this species from turkey are still lacking, since previous data have been based on a limited number of gray hamsters sampled across the anatolian part of turkey. the aim of this study was to determine the genetic diversity of the anatolian population and to reveal the phylogenetic relationships among the anatolian popul ...201728840764
agonistic anti-tigit treatment inhibits t cell responses in ldlr deficient mice without affecting atherosclerotic lesion development.co-stimulatory and co-inhibitory molecules are mainly expressed on t cells and antigen presenting cells and strongly orchestrate adaptive immune responses. whereas co-stimulatory molecules enhance immune responses, signaling via co-inhibitory molecules dampens the immune system, thereby showing great therapeutic potential to prevent cardiovascular diseases. signaling via co-inhibitory t cell immunoglobulin and itim domain (tigit) directly inhibits t cell activation and proliferation, and therefo ...201324376654
running hamster: a new type of mutant characterized as speedy, rotative running without motor and balance deficits.running hamster oyc (rho) is a mutant spontaneously arisen in a closed colony of armenian hamsters and has a characteristic of speedy, rotative running behavior. there are several reports which describe such mutants as abnormal walking behavior in rodents due to ataxia or balance deficits. in this report, we describe results of several motor and balance tests in order to clarify whether or not rho mutants have such disorders. rho mutants showed no sign of either motor or auditory deficits, and s ...200011109560
estrogen induction of hepatocellular carcinomas in armenian hamsters.liver tumors were found in most armenian hamsters (cricetulus migratorius) injected with on 15-mg pellet of diethylstilbestrol. the tumors were detectable as early as 1 1/2 mo after diethylstilbestrol administration and were usually present as multiple nodules that progressively increased in size. histologically, the multicentric neoplasms were all hepatocellular carcinomas of varied degrees of differentiation and frequently (42.8%) contained mallory bodies; preneoplastic lesions were not observ ...19902328952
malformed vertebrae in cricetulus migratorius (grey hamster): a case report. 1979529765
estrogen induces cytokeratin aggregation in primary cultures of armenian hamster hepatocytes.the effect of estrogen administration to cultured armenian hamster was studied. isolated armenian hamster hepatocytes were cultured in rpmi medium supplemented with beta-estradiol (e2). beta-estradiol treatment for 24-48 hr induced cytoplasmic inclusion bodies which by immunocytochemistry were positive for cytokeratin (ck) 8, ck 18, and ubiquitin but negative for ck 7 and ck 19. these inclusion bodies appeared as filamentous tangles or amorphous aggregates when observed by electron microscopy. f ...199910340701
spermatid micronucleus analysis of aging effects in hamsters.spermatid micronuclei (mn) from armenian hamsters in different age groups were compared with regard to frequencies and kinetochore status (presence or absence) as determined with immunofluorescent staining. six thousand cells analyzed from each of fifteen young animals (3 months) revealed a group mean frequency of 0.45 mn/1000 spermatids; kinetochore staining was uniformly negative. six thousand cells scored from each of fifteen older animals (2 years) revealed a group mean frequency of 1.00 mn/ ...19968649459
chromosome bonding patterns and idiogram of the armenia hamster, cricetulus migratorius. 1977837734
the relationship between chromosomes and axes in the chiasmatic xy pair of the armenian hamster (cricetulus migratorius). 19744457287
somatic cell hybridization: pattern of chromosome replication in viable chinese hamster x armenian hamster hybrids. 19705531479
identification of a monoclonal antibody specific for a murine t3 polypeptide.a monoclonal antibody (145-2c11) specific for the murine t3 complex was derived by immunizing armenian hamsters with a murine cytolytic t-cell clone. the antibody is specific for a 25-kda protein component (t3-epsilon) of the antigen-specific t-cell receptor. it reacts with all mature t cells and can both activate and inhibit t-cell function. these results identify t3-epsilon as a cell surface protein involved in the transduction of activation signals.19872950524
production of syrian and armenian hamster monoclonal antibodies of defined specificity. 19863724464
brdu-dye characterization of late replication and meiotic recombination in armenian hamster germ cells.in vivo brdu-dye methodology is used to reveal patterns of replication kinetics and meiotic recombination in male germ cells of the armenian hamster. analogue substitution over a fraction of the dna synthesis period results in distinctive 33258 hoechst fluorescence staining of late replicating chromatin, detectable at spermatogonial or spermatocyte i and ii stages. spermatogonial cells which are extensively substituted with brdu over the penultimate synthesis period reveal sister chromatid diffe ...1979574438
identification and characterization of jingmen tick virus in rodents from xinjiang, china.jingmen tick virus (jmtv) is a recently identified virus which provides an unexpected connection between segmented and unsegmented rna viruses. recent investigations reveal that jmtv including jmtv-like virus (alongshan virus) could be associated with human disease, suggesting the significance of jmtv in public health. to better understand the genetic diversity and host range of jmtv, a total of 164 rodents representing 8 species were collected in qapqal xibe county of xinjiang uygur autonomous ...202032531517
serological survey of neospora caninum and toxoplasma gondii co-infection in rodents in northwestern iran.our knowledge of the epidemiology of rodents' parasitic agents in iran is scarce, although some of these pathogens play an important role in human and veterinary medicine, such as toxoplasma gondii and neospora caninum. the purpose of this study was to determine the seroprevalence of toxoplasma gondii and neospora caninum in rodents of northwestern iran between mar and dec 2015.202032595716
toxoplasma gondii and neospora caninum in brain tissue of rodents in north-west iran.rodents live in proximity to humans and domestic animals. these creatures can serve as reservoir hosts for many zoonotic parasites; therefore, they increase the risk of human infections. the aim of this study was to investigate toxoplasma gondii and neospora caninum in rodents caught in meshgin-shahr district, iran.201931908996
geographic distribution and spatial analysis of leishmania infantum infection in domestic and wild animal reservoir hosts of zoonotic visceral leishmaniasis in iran: a systematic review.visceral leishmaniasis (vl) is an important parasitic disease which is endemic in different parts of iran; and domestic and wild canines are principal reservoir hosts of the disease. the objective of this study was to review the spatial distribution of canine vl (cvl) caused by leishmania infantum in domestic and wild canines in different geographical areas of iran. an extensive literature search was conducted in different international and national databases, including cochrane, medline/pubmed, ...201930618442
rodent-borne diseases and their public health importance in iran.rodents are reservoirs and hosts for several zoonotic diseases such as plague, leptospirosis, and leishmaniasis. rapid development of industry and agriculture, as well as climate change throughout the globe, has led to change or increase in occurrence of rodent-borne diseases. considering the distribution of rodents throughout iran, the aim of this review is to assess the risk of rodent-borne diseases in iran.201829672510
the fauna and perspective of rodentia ectoparasites in iran relying on their roles within public health and veterinary characteristics.historically, rodents-ectoparasites are responsible for many diseases in human and domestic animal communities because they are well-adapted to the environment and nutritional resources. in addition, ectoparasites can affect the reproductive rates, ecological fitness and the dispersal pattern of their hosts. data was compiled through all publications relating to ectoparasites fauna from iranian rodents. host specificity, rodent-parasites interaction, geographical distribution, ecological trends ...201829491552
contributions to the fauna of chigger mites (acariformes: trombiculidae) of iran.chigger mites of northern iran were studied on the basis of field collections from rodent hosts. thirty-five species were recorded. two new species, cheladonta afshari stekolnikov and shamsi sp. nov., collected on apodemus sp. in guilan and mazandaran provinces, and neotrombicula tehranensis stekolnikov and shamsi sp. nov., collected on cricetulus migratorius and chionomys sp. in tehran province, are described. one new synonym is established: neotrombicula vernalis (willmann, 1942) (= neotrombic ...202033056112
marmots and yersinia pestis strains in two plague endemic areas of tien shan mountains.the main purpose of this study was to clarify the role of gray marmots (marmota baibacina) in the long-term maintenance of highly virulent strains of yersinia pestis in two plague endemic foci of the tien shan mountains in kyrgyzstan. we present data from regular observations of populations of m. baibacina and small rodents cohabiting with marmots in the mountainous grasslands of the sari-dzhas (east of issyk-kul lake) and the upper-naryn (south of issyk-kul lake) natural foci. during 2012-2017, ...201931334249
[effects of skin γδ t lymphocytes on wound healing of mice through regulating proliferation and differentiation of mice epidermal cells].objective: to explore effects of dendritic epidermal t cells (detcs) and vγ4 t lymphocytes on proliferation and differentiation of mice epidermal cells and the effects in wound healing of mice. methods: (1) six c57bl/6 male mice aged 8 weeks were collected and divided into control group and wound group according to random number table (the same grouping method below), with 3 mice in each group. a 4 cm long straight excision with full-thickness skin defect was cut on back of each mouse in wound g ...201931060178
detection of pseudocyst forms of trichomonas muris in rodents from iran.trichomonas muris is one of the most common protozoa diagnosed in rodents. the trichomonads are generally described as presenting only trophozoite form while pseudocyst is another morphological form of trichomonads identified among gastrointestinal and genitourinary trichomonads. we identified and described different shapes of t. muris pseudocysts and trophozoite in stool samples were collected from rodents including merinos persicus, mus musculus and cricetulus migratorius.201829922616
molecular phylogenetics and taxonomy of dwarf hamsters cricetulus milne-edwards, 1867 (cricetidae, rodentia): description of a new genus and reinstatement of another.the taxonomy of the genus cricetulus has been controversial. the phylogenetic relationships both within the genus and among cricetulus lineages and other genera were examined using a set of five nuclear and two mitochondrial genes. the results demonstrate that cricetulus in its current treatment is a polyphyletic assemblage because the subgenus urocricetus is phylogenetically unrelated to all other cricetulus and is a distant sister group to phodopus. the grey hamster (c. migratorius) proved to ...201829689907
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