| neuroendocrine effects of perinatal androgenization in the male ferret. | | 1975 | 734 |
| prostaglandins in pyometrial fluid from the cow, bitch and ferret. | 1 pyometra is a disorder of the uterus usually associated with bacterial infection plus obstruction. 2 large quantities of fluid often collect in the uterus during this condition. 3 pyometrial fluid obtained from three species was found to contain prostaglandin f2alpha, usually in large quantities. 4 prostaglandin e2 was present in smaller quantities in five of the six samples. 5 these findings are discussed in relation to the known occurrence of prostaglandins in inflammatory fluid, and to the ... | 1975 | 2358 |
| direct measurement of the intracellular ph of mammalian cardiac muscle. | 1. the intracellular ph (phi) of sheep heart purkinje fibres and rat, ferret and guinea-pig ventricle has been measured using recessed-tip ph-sensitive micro-electrodes. 2. in the absence of co2 the phi was approximately 7-2 in all the preparations used. in 5% co2 the mean phi was 7-14 in rat and ferret ventricle and 7-02 in sheep purkinje fibres. 3. the phi response to an increase or a decrease in the co2 level (at constant external ph) was biphasic with a large transient change followed by a p ... | 1976 | 13205 |
| psychopharmacological influence on the prey catching behavior of ferrets (putorius furo l.) (author's transl). | the prey-catching behavior of ferrets (putorius furo l.) consists mainly of instinctive behavior patterns, which can be elicited only through their releaser. then they are performed stereotypically. to get information concerning the central background and the hierarchical structure of this behavior the neuroleptics haloperidol (0.14 mg/kg), clozapine (10 mg/kg) and chlorpromazine (4 mg/kg) were injected i.m. under controlled conditions. in a conditioning experiment the reactivity of the animals ... | 1977 | 14351 |
| the action of hypercapnia during hypoxia on pulmonary vessels. | two opposing actions of co2 on pulmonary vessels, vasoconstriction and vasodilatation, were studied in dogs, cats, ferrets and rats using isolated lungs or a lobe of lung in vivo. both preparations were perfused at a constant flow rate so that changes in inflow pressure at constant outflow pressure represented changes in vascular resistance. lungs were ventilated with 5-15 percent co2 during hypoxic vasoconstriction in order to permit demonstration of dilatation and because the two stimuli frequ ... | 1977 | 23189 |
| histamine receptors of airway smooth muscle of ferret and rat. | ferret trachea and bronchus contract to carbachol greater than 5-ht greater than bradykinin (bk) greater than pgf2alpha greater than histamine greater than 2-methylhistamine (2-meh: a specific h1-receptor agonist). rat trachea is insensitive to the spasmogenic actions of histamine, 2-meh, pgf2alpha, bk and 5-ht. ferret trachea and bronchus and rat trachea (which were partially contracted to carbachol) relax to isoproterenol greater than pge1 greater than e2 greater than 4-methyl-histamine (4-meh ... | 1978 | 28556 |
| relation between transmucosal potential difference, ionic flux, and the intraluminal supply of h+ in the ferret stomach. | to investigate the relation between gastric transmucosal potential difference, ionic flux, and the intraluminal concentration of h+, test solutions containing various concentrations of hcl were instilled into ferret stomachs both before and after exposure to various doses of acetic acid. the changes in ionic composition of the test solution were determined and the transmucosal potential difference was recorded throughout each experiment. the results showed that after exposure to the organic acid ... | 1979 | 36767 |
| immunological studies of subacute measles encephalitis in ferrets: similarities to human subacute sclerosing panencephalitis. | ferrets inoculated with subacute sclerosing panencephalitis virus strains d.r. and biken developed a subacute encephalitis. brain extracts, at neutral ph, from these ferrets showed high measles antibody titers, increased concentrations of immunoglobulin g (igg), and higher igg/albumin ratios than those of controls. although the brain extracts of subacute encephalitic animals showed significant synthesis of measles-specific igg (20 to 60% of the total igg) within the central nervous system, the e ... | 1979 | 39084 |
| cytochemical localization of transport adenosine triphosphatase in the ferret placenta. | the distribution of transport adenosine triphosphatase in the ferret placenta was examined cytochemically by light and electron microscopy. the enzyme was detected in the syncytiotrophoblast but was absent from maternal tissues. it appeared to be associated with cytoplasmic processses on syncytiotrophoblast surfaces directly related to foetal or maternal capillaries. the functional significance of transport adenosine triphosphatase is discussed with reference to the transport of solutes between ... | 1976 | 60306 |
| antigenic variants of influenza a virus obtained in vitro. | the aim of this study was to investigate antigenic "drift" in the haemagglutinin and neuraminidase antigens of influenza a virus in vitro under immunological pressure. variants of the "asian" influenza strains a/england/12/64 (h2n2) and a/tokyo/3/67 (h2n2) were isolated in the allantois-on-shell system in the presence of homologous postinfection ferret sera. for each of these two viruses three generations of variants were isolated and characterized. it was found that the successive antigenic var ... | 1976 | 62624 |
| the accessory optic system of the ferret. | the accessory optic system of the ferret has been studied both by silver degeneration staining and by autoradiography after intraocular 3h leucine injections. there is no anterior accessory optic tract but a posterior tract containing only crossed fibres leaves the brachium of the superior colliculus and ends in the two nuclei, the medial and lateral terminal nuclei, lying either side of the cerebral peduncle. both suprachiasmatic nuclei receive retinal fibres visible only on autoradiographs; mo ... | 1976 | 62769 |
| behaviour in ferrets of swine influenza virus isolated from man. | after intranasal instillation into ferrets, the "swine" influenza virus a/new jersey/8/76(hsw1 n1) had a 50% minimal infectious dose similar to that of previously tested a/pr/8-a/england (h3 n2) recombinants virulent and attenuated for man. a/new jersey produced only a mild upper respiratory tract infection. however, higher titres of virus were recovered from the lungs over a longer period than experienced previously with asian and hong kong virus strains. there was a diphasic pyrexia the second ... | 1977 | 63712 |
| pilot studies on recombinant cold-adapted live type a and b influenza virus vaccines. | recombinant live attenuated type a and b influenza virus vaccines derived from standardized cold-adapted parent strains were given singly and in combination to volunteers. the vaccine viruses were well tolerated, functioned as good antigens, and failed to spread to intimate household contacts. thirty-nine isolates that were recovered after a single passage in humans appeared genetically stable. the results of histopathologic studies in ferrets encourage development of an animal model for attenua ... | 1977 | 69670 |
| co-circulation of two influenza a (h3n2) antigenic variants detected by virus surveillance in individual communities. | from march through june 1977 a total of 31 influenza a (h3n2) viruses were isolated from students with respiratory disease who were seen at the student health service on the berkeley campus of the university of california, and 32 influenza a (h3n2) viruses were isolated from persons who participated in a city-wide febrile respiratory disease surveillance program in seattle. the antigenic specificity of the hemagglutinin was determined for each isolate by hemagglutination inhibition testing with ... | 1978 | 83107 |
| further studies of the antigenic properties of h3n2 strains of influenza a isolated from swine in south east asia. | h3n2 strains of influenza a isolated from swine in hong kong were compared with human strains of h3n2 influenza a variants in reciprocal hi tests using ferret sera. one isolate from swine was indistinguishable from a/hong kong/68, one set of viruses isolated in 1976 and 1977 was most related to a/hong kong/68 but was not identical to it, two isolates from 1976 were 'bridging strains' that cross-reacted equally with the contemporary variants a/victoria/3/75 and a/texas/1/77, similarly to a small ... | 1979 | 91663 |
| histology and mucosubstance histochemistry of ferret lingual glands. | the histology and mucosubstance histochemistry of the ferret lingual glands were studied. both serous and mucous minor salivary glands were present in the posterior part of the tongue. in serous glands, acinar cells and a very few cells of the excretory ducts contained granules which gave reactions for neutral mucopolysaccharides only. the mucous glands, including the duct system, contained mainly weakly sulphated acidic mucin, some neutral mucin but no carboxylated mucin. occasional goblet cell ... | 1979 | 93387 |
| the use of ferret trachea organ cultures for therapeutic studies of anti-influenzal drugs. ii. comparison of four compounds in tissue culture and in organ culture. | | 1978 | 97260 |
| the histochemistry of mucosubstances in ferret salivary glands. | the mucosubstances of the major salivary glands of the ferret were analysed using different histochemical reactions. almost all the parotid acinar cells had sialic acid-containing mucus. there were a very few cells, the granules of which gave reactions for sulphated mucins. submandibular gland mucus was sulphated in the major parts of the gland. there were occasional cells which gave reactions to carboxylated mucin. the sublingual and the molar glands had tubules which had 2 types of mucous cell ... | 1978 | 97904 |
| instinctive predatory behavior of the ferret (putorius putorius furo l.) modified by chlordiazepoxide hydrochloride (librium). | the predatory behavior of ferrets (putorius putorius furo l.) consists mainly of instinctive behavioral patterns that are elicited by simple external stimuli. for the ferret, the time needed to catch and kill rats depends on the size of the rats in relation to that of the ferret. killing success decreases with a relative increase in prey size. chlordiazepoxide hydrochloride injections (1 mg/kg, i.m.) modified this behavior. drugged ferrets needed less time and less bites to kill relatively large ... | 1978 | 103120 |
| antigenic relationship between influenza c viruses. | the object of this study was to determine whether antigenic groupings exist among influenza c viruses. altogether seven influenza type c strains were examined by reciprocal haemagglutination-inhibition and serum neutralization tests with sera produced in ferrets. some biological properties were also compared and differences were found in their ability to agglutinate erythrocytes from various species, in their ability to adsorb onto rat and fowl erythrocytes, and in their rates of elution from th ... | 1978 | 104696 |
| the effect of treatment with a polychlorinated-biphenyl mixture on hepatic and extrahepatic xenobiotic metabolism in the rat and ferret [proceedings]. | | 1978 | 105952 |
| [evidence of a circadian sequence of photogonadsensitivity in the ferret]. | using "skeleton" photoperiods with a primary photofraction of 3 hrs. 30 min. and secondary photofraction of 30 min. located at various intervals after the onset of darkness, the occurrence of a photoinducible phase in the androgenic function has been evidenced in the ferret. this photo-inducible phase seems to be located around 12 hrs. after the onset of the primary photofraction, since the ferrets who received the 30 min. photofraction 8 hrs. after the onset of darkness responded with a maximal ... | 1978 | 106984 |
| [the ferret (putorius putorius furo), an additional final host of sarcocystis muris (author's transl)]. | two ferrets were fed mice experimentally infected with sarcocystis muris. after 7 days they excreted with their faeces for 9 days sporocysts which were morphologically indistinguishable from s. muris sporocysts. five mice which each received 70 of these sporocysts orally developed macroscopically visible cysts of s. muris in their musculature after 4 months. | 1979 | 107667 |
| comparative aspects of blastocyst-endometrial interactions at implantation. | since the trophoblast-uterine adhesion is as nearly a universal phenomenon in implantation as can be found, an attempt was made to determine whether or not there was a reduction in cell surface glycoproteins in the rat, as can be observed in the ferret. neither colloidal iron nor cationized ferritin revealed the type of pattern anticipated for a localized reduction in surface negativity in the imprint of the blastocyst in the implantation chamber. the use of lectin-coated latex beads also proved ... | 1978 | 115657 |
| effects of d-amphetamine, maprotiline, l-dopa, and haloperidol on the components of the predatory behavior of the ferret, putorius furo l. | ferret predation on rats was examined in an arena. one hour before the test one of the following drugs was administered. d-amphetamine (0.8 and 1.4 mg/kg im), maprotiline (10 and 40 mg/kg orally), l-dopa (30 and 60 mg/kg orally), or haloperidol (0.14 and 0.6 mg/kg im). provided that capture was successful, the sequence of the behavioral components was not changed by these drugs. with the exceptions of paw movements and rolling over, which were not affected by the drugs, the components of predato ... | 1979 | 116280 |
| the induction of hepatic and extrahepatic xenobiotic metabolism in the rat and ferret by a polychlorinated biphenyl mixture (aroclor 1254). | 1. the effect of a single i.p. dose (500 mg/kg) of a polychlorinated biphenyl mixture (aroclor 1254) on hepatic and extrahepatic xenobiotic metabolism in male rat, and male and female ferret, was studied. 2. aroclor 1254 treatment induced hepatic microsomal n-demethylase activities, and cytochrome p-450 and protein content in both rat and ferret. liver size and aniline 4-hydroxylase were also increased in rat, but not ferret. the polychlorinated biphenyl mixture appeared to be a mixed-type induc ... | 1979 | 119357 |
| differentiation of coital behavior in mammals: a comparative analysis. | the evidence reviewed suggests that in all mammalian species the adult male's ability to display masculine coital behavior depends in part on exposure of the developing brain to testicular testosterone or its metabolites. in many mammals, particularly rodents, ruminants, and some carnivores, perinatal exposure to androgen also causes behavioral defeminization, i.e., reduced capacity to display typically feminine coital behavior in response to gonadal hormones in adulthood. the data reviewed sugg ... | 1979 | 120519 |
| attempted experimental cross infections with mammalian guinea-worms, dracunculus spp. (nematoda: dracunculoidea). | dracunculus medinensis and d. insignis are morphologically indistinguishable. experiments to test the susceptibility of various mammalian hosts to these two guinea worm species are described. infective 3rd-stage larvae of d. medinensis were administered to each of four raccons (procyon lotor): infective 3rd-stage larvae of d. insignis were administered to a rhesus monkey (macaca mulatta), two dogs, two ferrets (mustela putorius furo), and a marten (martes americana). d. medinensis was not found ... | 1976 | 134642 |
| an animal model for studying infection and immunity to and attenuation of human parainfluenza viruses. | neonatal ferrets were found to be highly via the intranasal route of inoculation to infection with wild type isolates of parainfluenza viruses. wild type infection consistently resulted in deaths of these animals in 48 to 72 hours. autopsy and histopathological findings in lung tissue were consistent with those of viral infection. virus could consistently be isolated from lung tissues. using wild green monkey kidney grown viruses and selected passage levels of egg adapted viruses, virus attenuat ... | 1975 | 165121 |
| evaluation of 6-azauridine and 5-iododeoxyuridine in the treatment of experimental viral infections. | the potential antiviral activity of 6-azauridine and 5-iododeoxyuridine was evaluated in a coordinated study at five institutions. experimental models in five species, the mouse, rabbit, swine, cat, and ferret, were established with use of 10 viruses: herpesvirus hominis types 1 and 2, murine cytomegalovirus, vaccinia virus, shope fibroma virus, transmissible gastroenteritis virus, swine influenza virus, feline viral rhinotracheitis virus, feline panleukopenia virus, and ferret distemper virus. ... | 1976 | 180189 |
| [isolation of reoviruses from mink]. | in this first report of the isolation of reovirus from mink, isolates were obtained from 18 to 26 young mink with viral enteritis, by using cultures of cat kidney cells. the isolated also produced cytopathic changes in cell cultures of mink kidney, dog kidney, piglet kidney, calf kidney, bovine embryonic kidney and calf testis. a characteristic feature was the formation of eosinophilic inclusion bodies in the cytoplasma of culture cells. haemagglutination tests were negative with erythrocytes fr ... | 1975 | 180927 |
| further studies on the neonatal ferret model of infection and immunity to and attenuation of human parainfluenza viruses. | earlier we reported on the susceptibility via the intranasal route of inoculation of newborn ferrets to infection by wild and serially egg passaged parainfluenza type 3 virus. the wild type consistently induced fatal infection whereas with serial egg passage, mortality rate decreased while the degree of infectivity remained the same. this attenuation was accompanied by a change in capacity to induce interferon and decreased growth in human and primate cell cultures. the present work reports, sim ... | 1976 | 182598 |
| the hepatic effects of orally administered di-(2-ethylhexyl) phthalate in the ferret. | | 1977 | 196961 |
| vesicular stomatitis virus causes abortion and neonatal death in ferrets. | vesicular stomatitis virus caused transplacental infection in ferrets, resulting in infant death. no clinically significant illness was observed in the adult, despite histological changes in the uterus, liver, and spleen. | 1977 | 199615 |
| properties of aleutian disease virus assayed with feline kidney cells. | properties of aleutian disease virus (adv) were studied using feline kidney cells, line crfk, to assay virus by the induction of nuclear antigen. adv nuclear antigen was detected by immunofluorescent staining. titers of virus obtained from mink spleens at 10-8 days after infection were usually between 10(3) and 10(5) infectious units per gram of spleen. adv was purified by fluorocarbon extraction, differential centrifugation, biogel a-15 chromatography and cscl equilibrium centrifugation. the mo ... | 1977 | 202229 |
| experimental infectious bovine rhinotracheitis virus infections of english ferrets (mustela putorius furo l). | intranasal and intraperitoneal exposure of english ferrets (mustela putorius furo l) to infectious bovine rhinotracheitis virus caused acute and chronic infections of the respiratory tract. the clinical syndrome was characterized by sneezing, coughing, and anorexia from postexposure days (ped) 3 to 7. mucopurulent exudate was observed in the posterior nares and pharyngeal area of ferrets euthanatized on ped 4 and 8. the virus was readily recovered from the turbinates, respiratory tract epitheliu ... | 1978 | 211885 |
| easily hydrolyzable, water-soluble derivatives of (+/-)-alpha-5-[1-(indol-3-yl)ethyl]-2-methylamino-delta2-thiazoline-4-one, a novel antiviral compound. | the preparation of a series of indole n-acyl and n-carbamic esters of (+/-)-alpha-5-[1-(indol-3-yl)ethyl]-2-methylamino-delta2-thiazolin-4-one (1) is reported. these derivatives were synthesized as potential water-soluble precursors of the antiviral thiazolinone 1, for evaluation by intranasal administration against influenza and other respiratory infections caused by viruses. salts of the basic carbamic esters (16--19) possess the required water solubility, undergo rapid hydrolysis and decarbox ... | 1979 | 218010 |
| [pathology of the polymorphonuclears in dermatology. methods of investigation. clinical pictures (author's transl)]. | a remarkable increase in the number of recognized clinical abnormalities of neutrophil function has occurred within the 8 years past. of major importance in the delineation of these disorders is the establishment of appropriate methodology of their characterization. this review discusses phagocytosis and its disorders by dividing it into stages that encompass the way in which phagocytes ferret out injection, how they recognize pathogens and the intracellular events leading to engulfment and kill ... | 1979 | 224753 |
| the local origin of the febrile response induced in ferrets during respiratory infection with a virulent influenza virus. | | 1979 | 224895 |
| h1 and h2 histamine actions on lung vessels; their relevance to hypoxic vasoconstriction. | pulmonary vasomotor actions of histamine and the possible relationship of histamine to hypoxic pulmonary vasconstriction were studied in anaesthetized cats with one lobe of lung perfused at constant flow and in isolated perfused rat and ferret lungs. in the cat histamine caused dilatation, biphasic responses and constriction with increasing doses. histamine induced dilatation was better demonstrated during hypoxic vasoconstriction and was reduced by an h2 histamine antagonist; constriction with ... | 1978 | 247533 |
| bilateral cataracts in a ferret. | | 1979 | 260553 |
| protective efficacy of rit 4025, a live attenuated influenza vaccine strain, and evaluation of heterotypic immunity to influenza a viruses in ferrets. | ferrets immunized with an h3n2 recombinant of a/pr/8/34 and a/scotland/840/74 (rit 4025 vaccine strain) were almost completely protected against a challenge with the homologous strain a/scotland/840/74. the protection was lower but highly significant when the challenge was performed with the heterologous a/victoria/3/75 wild strain. the protection afforded by the vaccine strain was measured by three indicators: absence of temperature rise, absence or reduction of virus shedding and absence or re ... | 1977 | 269196 |
| regional b-cell responses to inactivated influenza virus vaccine in ferrets. | | 1979 | 314480 |
| a comparison of the composition and apolipoprotein content of the lipoproteins isolated from human and ferret (mustela putorius furo l.) serum. | 1. the lipoproteins isolated at densities of less than 1.006, 1.006-1.063 and 1.063-1.21 g/ml from human and ferret (mustela putorius furo l.) serum were compared. 2. ferret very low density lipoprotein contained proportionately less triglyceride and more phospholipid than human. 3. ferret low density lipoprotein contained proportionately more triglyceride and less cholesterol than human. 4. high density lipoprotein was the major lipoprotein in ferret serum. 5. the gel electrophoretic patterns o ... | 1978 | 318359 |
| the effect of hypothalamic lesions on the pars intermedia of the ferret. | | 1977 | 323099 |
| effects of luteinizing hormone releasing hormone on plasma follicle-stimulating hormone and luteinizing hormone levels in the ferret. | heterologous radioimmunoassays for fsh and lh were employed to examine the effect of synthetic lh-rh upon gonadotrophin secretion in the ferret. intravenous injection of 4 microng lh-rh induced a surge of fsh and of lh secretion in male and in female animals. in intact and in castrated males, the rise of lh was much more marked than that of fsh. the gonadotrophin response to lh-rh was greater in anoestrous than in oestrous females; fsh secretion was not enhanced during oestrus. ovariectomized fe ... | 1977 | 323395 |
| the use of ferret trachea organ cultures for therapeutic studies of anti-influenzal drugs. i. evaluation of the model in comparison with infection in humans. | | 1977 | 340440 |
| taurine conjugates as metabolites of arylacetic acids in the ferret. | 1. the pattern of conjugation in the ferret of 8 arylacetic acids and, for comparison, benzoic acid and 4-nitrobenzoic acid was examined. 2. the arylacetic acids, phenylacetic, 4-chloro- and 4-nitro phenylacetic, alpha-methylphenylacetic (hydratropic), 1- and 2-naphthylacetic and indol-3-ylacetic acids, were excreted in the urine as taurine and glycine conjugates. diphenylacetic acid did not form an amino acid conjugate and was excreted as a glucuronide. 3. the taurine conjugate was the major me ... | 1978 | 347725 |
| pathogenesis of respiratory syncytial virus infection in ferret and fetal human tracheas in organ culture. | the pathogenesis of human respiratory syncytial virus infection was studied in ferret and fetal human tracheas in organ culture. although the patterns of virus growth were similar in these species, the sites and morphologic consequences of virus replication differed markedly. in human trachea, synthesis of respiratory syncytial virus occurred in a population of ciliated epithelial cells, whereas other cells in the epithelial layer were spared. virus replication was associated with cell injury ch ... | 1978 | 354444 |
| the pathogenesis of respiratory syncytial virus infection in cotton rats. | the cotton rat is susceptible to respiratory synctial virus infection in both the upper and lower portions of the respiratory tract. virus replicates to high titer in the nose and lungs and to relatively low titer in the trachea. immunofluorescence studies demonstrated viral antigen in the nasal epithelium and the bronchial and bronchiolar epithelium but not in the trachea or the alveolar cells of the lungs. histopathologic changes included a desquamative, exudative rhinitis of moderate severity ... | 1978 | 362946 |
| regional t- and b-cell responses in influenza-infected ferrets. | ferrets were infected with a/port chalmers/72 influenza virus and the t- and b-cell responses in the spleen, in lymph nodes draining the upper and lower respiratory tract, and in lung washings were examined in vitro. lymphocyte responses were measured by using a hemolytic plaque assay for b cells and a proliferation assay for t cells. virus and antibody levels were measured in respiratory tract washings, and antibody titers were measured in sera from infected animals. individual b cells secretin ... | 1978 | 365744 |
| the ferret and its diseases. | | 1978 | 367994 |
| live influenza vaccine: screening of attenuated virus strains by a 50% ciliary activity inhibition test in organ cultures of ferret trachea. | this study of three live attenuated inhibitor-resistant influenza vaccines showed that these preparations are usually antigenic and that they caused no significant reactions when characterized by an index of attenuation equal to or slightly better than 1.0 arbitrarily attributed to the 'reference' attenuated a/hong kong/68 strain of beare and bynoe. this index, measured in vitro on ferret tracheal rings, is expressed as the ratio of the time required for ciliary activity inhibition of 50% of the ... | 1979 | 378337 |
| comparison of sevral wild-type influenza viruses in the ferret tracheal organ culture system. | several strains of wild-type influenza a virus were studied in the ferret tracheal organ culture system. ciliary activity and viral replication were measured. ciliary activity was reduced more rapidly by a/hong kong/45/68 (h3n2) (a/hk) and a/victoria/3/75 (h3n2) (a/vic) than by a/new jersey/8/76 (hsw1n1) (a/nj), a/scotland/840/74(3hn2) (a/scot), or a/ussr/90/77 (h1n1) (a/ussr). a/hk, a/vic, and a/scot produced titers of virus higher than a/ussr or a/nj during the first three days after infection ... | 1979 | 399387 |
| sulfhydryl-mediated depression of ciliary activity: an adverse effect of acetylcysteine. | although n-acetyl-l-cysteine (mucomyst) is an effective mycolytic, numerous investigations have failed to demonstrate a consistent improvement in pulmonary mechanics following its use. in order to determine whether its beneficial mucolytic activity might be counterbalanced by a deleterious direct effect on cilia, we studied its effect on the activity of ciliated epithelium in the ferret tracheal organ culture system. n-acetyl-l-cysteine consistently caused progressive time-dependent ciliostasis ... | 1979 | 429865 |
| the atrioventricular node and bundle in the ferret heart: a light and quantitative electron microscopic study. | the cells of the atrioventricular (av) junction in the ferret heart were examined using light microscopy, a wax-model reconstruction and quantitative electron microscopy to determine their organization and characteristics. a series of subdivisions of the specialized tissues of the av junction was apparent at both the light and electron microscopic levels. a transitional zone was observed interposed between the atrial muscle cells and the av node. the av node consisted of a coronary sinus portion ... | 1979 | 433788 |
| [adpatibility of 2 rabies virus strains isolated in middle europe to a domestic and 2 wild species. a contribution to the epidemiology of rabies. 4. transmission studies in ferrets with a rodent isolate]. | | 1979 | 442882 |
| brugia pahangi and dirofilaria immitis: experimental infections in the ferret, mustela putorius furo. | | 1979 | 446585 |
| immunoprophylaxis of respiratory syncytial virus infection in the infant ferret. | infant ferrets can be protected from respiratory syncytical virus challenge at 3 days of age by gestational infection of their mothers. ferrets acquire their immunity to respiratory syncytial virus postpartum via immunizing products of lactation. the level of protection against viral replication correlates with the maternal serum neutralizing titer or a concomitant factor. passive administration of adult ferret serum with a neutralizing titer of 1:1024 or greater, either i.p. or orally does not ... | 1979 | 448139 |
| ontogeny of the ferret humoral immune response. | infant ferrets are born with nearly undetectable immunoglobulin levels, but by 9 days of age the infant ferret serum contains 77, 29, and 13% of adult mean serum levels of igg, iga, and igm. transmucosal uptake of igg by the infant ferret occurred for the first 30 days of life. the specific anti-respiratory syncytial virus neutralizing titer of whole milk was 5.5 times higher than maternal serum despite a lower concentration of immunoglobulins in the milk. | 1979 | 448158 |
| the search for the ideal influenza vaccine. | the history of the development of influenza virus vaccine is traced from its origin with experimental studies of influenza virus in ferrets and mice and the first trials in man. knowledge of the basis of immunity to the viruses in experimental animals and in man has grown steadily over the years and has been essential to successful immunization. virus variation affecting the surface antigens of the virus is seen as the principal obstacle to the application of vaccines in man. so significant are ... | 1979 | 461277 |
| probit analysis of the atrioventricular (av) junctional tissues of the ferret heart. | probit frequency analysis, a graphic method for determining whether a population is normally distributed, skewed, or multinodal, was used to determine whether p cells are present in different regions of the av junction in the ferret heart. this analysis indicated that at least 95% of the cells of the transitional zone, superficial av node, deep av node, and distal av bundle of the ferret heart are morphologically homogeneous. in the proximal av bundle a large cell population is found in addition ... | 1979 | 476796 |
| vagal afferent discharge from tension receptors in the ferret stomach [proceedings]. | | 1979 | 480221 |
| the ferret, mustela putorius furo, as a new species in toxicology. | comprehensive studies on the haematology, urine chemistry, serum chemistry and gross pathology have been carried out and reported. seasonal weight changes were confirmed and were initiated, together with sexual activity, when ferrets were brought in to a constant temperature (18-19 degrees c) and 14-hour daylight cycle during the winter months. levels of haemoglobin, erythrocytes and haematocrit were higher than in most common laboratory species. similarly, serum electrolytes and glucose levels ... | 1979 | 480899 |
| the role of prolactin in implantation and luteal maintenance in the ferret. | | 1979 | 486673 |
| effects of atropine on secretion and motility in isolated gastric mucosa and attached muscularis externa from ferret and cat. | 1. a combined in vitro preparation of gastric mucosa and adjacent muscle from young ferrets and kittens has been used to study the effects of atropine on acid secretion and motility produced by acetylcholine (ach) and pentagastrin.2. the minimal dose of atropine required to abolish a maximum secretory response to ach also prevented the associated motility response. this dose of atropine also blocked the motility response to pentagastrin, but was without influence on the secretory effect of this ... | 1979 | 490363 |
| ouabain increases the slow inward calcium current in ventricular muscle of the ferret [proceedings]. | | 1979 | 490409 |
| behavior of vaccine revertants of temperature-sensitive mutants of influenza virus in ferret tracheal organ culture. | a live attenuated influenza vaccine candidate was not genetically stable when administered to some children who lacked antibody to surface proteins of the virus. to obtain additional biological information about these revertants, the vaccine strain, the wild-type parental strain, and isolates recovered from inoculated children during a vaccine trial were evaluated in ferret tracheal organ culture for effects on the ciliated epithelium and replication at both permissive and restrictive temperatur ... | 1979 | 500202 |
| comparisons of virulence of influenza virus recombinants in ferrets in relation to their behaviour in man and their genetic constitution. | two parent viruses, a/finland/4/74(h3n2) and a/okuda/57(h2n2), virulent and attenuated respectively for man, showed similar differences of virulence in ferrets as judged by estimations of 50% minimal infectious doses (mid50), the level and persistence of nasal infection, the height and duration of pyrexia and the level of lung infection. in ferrets, two recombinant clones, wrl 94(h3n2) and wrl 105(h3n2), were almost as virulent as a/finland and indistinguishable from one another, a result which ... | 1979 | 501338 |
| [seasonal changes of testicular function in two mustelids : ferret (mustela furo l.) and mink (mustela vison s.) (author's transl)]. | | 1979 | 501662 |
| mucosubstance histochemistry of brunner's glands, pyloric glands and duodenal goblet cells in the ferret. | the mucosubstance of brunner's glands, pyloric glands and duodenal goblet cells were studied using the various histochemical methods. the secretions of both brunner's and pyloric glands were similar in their histochemical reactions. they contained neutral mucosubstances as in these glands in man. the duodenal goblet cells showed variations in their histochemical characters. (i) the secretions of most of the deep cells and the majority of superficial cells contained sialidase-labile and sialidase ... | 1979 | 521321 |
| the localization of influenza virus in the respiratory tract of ferrets: susceptible nasal mucosa cells produce and release more virus than susceptible lung cells. | infectious virus production by ferret nasal mucosa and lung organ cultures has been monitored in both tissue pieces and medium over 24 h following inoculation with an asian (h2n2) strain of influenza virus. freshly prepared cultures of nasal mucosa produced approx. 10-fold more virus per cell than fresh lung cultures. also the nasal mucosa cells liberated into the medium a greater proportion (mean 31%) of the total virus produced than did fresh lung (mean 6%). maintenance of lung explants for 24 ... | 1979 | 521800 |
| a correlative light microscopy, transmission and scanning electron microscopy study of the ferret lung. | | 1979 | 524059 |
| anaesthesia of the ranch mink (mustela vison) and ferret (mustela putorius furo). | | 1979 | 538879 |
| [tkhorzofretka (a hybrid of mustela furo l. and m. putorius l.), a new laboratory model animal for plague in carnivores]. | | 1979 | 543076 |
| some observations of anatomical abnormalities and disease states in a population of 350 ferrets (mustela furo l.). | | 1979 | 549381 |
| some aspects of the physiology and anatomy of the cardiovascular system of the ferret, mustela putorius furo. | the resting heart rate was monitored in 50 urethane-anaesthetized (387 +/- 54 beats/min) and 4 conscious (341 +/- 39 beats/min) ferrets. the arterial blood pressure in the anaesthetized animals was 140/110 +/- 35/31 mmhg. the circulatory responses to vagal stimulation, carotid artery occlusion and a variety of humoral agents were examined. the vagal innervation of the heart and of the distribution of the great vessels are described. | 1979 | 553192 |
| vaccine-induced canine distemper virus in black-footed ferrets. | | 1977 | 556720 |
| the pregnant guinea-pig as a model for studying influenza virus infection in utero: infection of foetal tissues in organ culture and in vivo. | organ cultures of guinea-pig foetal tissues showed a similar pattern of susceptibility to influenza virus to that already observed for human (rosztoczy et al., 1975) and ferret (sweet, toms and smith, 1977) foetal tissues. respiratory, alimentary and urogenital tract tissues were susceptible whereas neural and lymphopoietic tissues were insusceptible. however, of the foetal membranes (amnion, chorion, umbilical cord and placenta) only the chorion was susceptible, in contrast to the corresponding ... | 1977 | 558788 |
| stimulation of the hypothalamus and fsh and lh secretion in the ferret. | the acute effects of hypothalamic electrical stimulation on the secretion of fsh and lh have been examined in anestrous and estrous ferrets. basal levels of luteinizing hormone (lh) and follicle-stimulating hormone (fsh) were higher in the anestrous than in the estrous animals; the anestrous animals showed a more marked increase in gonadotropin levels following hypothalamic stimulation than did the estrous animals whether the stimulation current was constant or increased in the course of the exp ... | 1977 | 563530 |
| contact transmission of distemper virus in ferrets. | distemper virus was transmitted when infected donor ferrets were placed with susceptible ferrets for various contact periods. distemper was more likely to be transmitted during the later stages of the disease. a positive correlation was found between the length of contact time and the acquisition of infection. | 1978 | 564540 |
| local anesthetics and tracheal ring ciliary activity. | the effects of local anesthetics on ciliary activity were studied using ferret tracheal rings maintained in vitro. ciliary activity was quantitated visually after exposure to varying concentrations of mepivacaine, lidocaine, procaine, chloroprocaine, and bupivacaine. the recovery of ciliary activity was determined after tracheal rings were washed free of the local anesthetic agent. mepivacaine was the least toxic, with no effect on ciliary activity at a 1.0% concentration. bupivacaine was the mo ... | 1978 | 568406 |
| adverse effects of lidocaine and methylparaben on tracheal ciliary activity. | the effect of standard concentrations of lidocaine hcl and methylparaben (preservative) on the ciliary activity of ferret tracheal rings in organ culture was assessed. pure lidocaine concentrations as low as 0.5% caused complete ciliostasis which was reversible after removal of the drug. one percent and two percent effects were not completely reversible. pure methylparaben concentrations as low as 0.06 mg/ml paralyzed cilia; and, at concentrations of 0.5 mg/ml or higher, adverse effects were not ... | 1979 | 574178 |
| impairment of tracheal ring ciliary activity by halothane. | the effects of varying concentrations of halothane on tracheal ciliary activity were studied using a ferret tracheal organ culture technique. using 1% and 2% halothane produced no impairment of ciliary activity, while 3% halothane caused some ciliostasis; 4% and 5% halothane produced rapid cessation of ciliary activity. recovery was prompt and complete after exposure to 4% halothane for as long as 3 days, but after 4 days of exposure recovery was incomplete and after a week of exposure death of ... | 1979 | 574736 |
| the localization of influenza virus in the respiratory tract of ferrets: the importance of early replication events in determining tissue specificity. | | 1977 | 579185 |
| drug metabolism in the ferret: effects of age, sex and strain. | | 1977 | 590731 |
| the peripheral organization of vagal gastric motility fibres in the ferret [proceedings]. | | 1977 | 592156 |
| one-year toxicity study of orange g in the ferret. | | 1977 | 598788 |
| in vitro markers for measuring residual virulence for men of live attenuated influenza viruses. | human and equine influenza strains attenuated by consecutive passages in the presence of normal horse serum (nhs) on allantois-on-shell system (aos) and administered to human volunteers or horses as possible live virus vaccine candidates were tested in organ cultures of ferret and hamster trachea. temperature sensitivity, virus replication, interferon induction and neuraminidase activity were also investigated. observation of the ciliary activity of each ring was made daily. influenza strains wh ... | 1977 | 604117 |
| antigenic subgroups of influenza a (hsw1 n1) virus differentiated by hemagglutination inhibition. | eleven influenza a/swine virus strains could be arranged in three subgroups by hemagglutination inhibition (hi) titrations. the antisera used include post-infection ferret sera (native as well as after adsorption with heterologous hsw1 n1 virus) and paired human sera from recent influenza a patients, showing antibody titre rises against a/swine virus. for serological detection of infections with an unknown a/swine virus, virus strains of the subgroup with the broadest reactivity are more suitabl ... | 1977 | 604129 |
| thermal stability and interaction with ferret inflammatory exudates of two clones of influenza virus of differing virulence for both ferrets and man. | | 1977 | 607985 |
| species variation in the distribution of cholinesterases in the ovary of the plains viscacha, cat, ferret, rabbit, rat, guinea-pig and roe deer. | sections of ovary from plains viscacha, cat, ferret, rabbit, rat, guinea-pig and roe deer have been histochemically processed to demonstrate acetylcholinesterase (ache) and butyrylcholinesterase (buche) in nervous and non-nervous tissue. the effects of different reproductive states on enzyme activity were observed in some animals. ache-containing nerves were sparse in rabbit and rat but plentiful in cat and roe deer. nerves containing buche were not detectable in ferret or guinea-pig and were ra ... | 1978 | 621163 |
| [cytogenetics of albinism in polecats of the genus putorius (carnivora, mustelidae)]. | karyotypes of two ferret species, putorius eversmanni (2n = 38) and p. putorius (2n = 40), differ in a single robertsonian rearrangement, resulting in decreased chromosome number in p. eversmanni. interspecific hybrids from crosses between p. eversmanni and domesticated albino ferret p. putorius furo are fertile. hybrid individuals have a chromosome set 2 = 39. analysis of offspring from crosses of these hybrids showed that albinism is a recessive character. offspring obtained from crosses betwe ... | 1978 | 627343 |
| dirofilaria immitis: experimental infections in the ferret (mustela putorius furo). | the ferret, mustela putorius furo, was found to be susceptible to dirofilaria immitis infection when exposed to low (14) or high (280-420) numbers of infective larvae harvested from aedes aegypti. eight ferrets (half of them cortisonized) were inoculated subcutaneously with 14 larvae each. all of them were subsequently found to harbor d. immitis in the heart, and all but one of them had worms of both sexes. six of these ferrets were examined for microfilaremia at 31 to 35 weeks after inoculation ... | 1978 | 627949 |
| acid secretion and motility of isolated mammalian gastric mucosa and attached muscularis externa. | a procedure is described for the setting up of a preparation of mammalian gastric mucosa from kitten or ferret. the mucosa is stripped of its outer muscle coats except for a 2-mm strip of circular muscle fibers running across the diameter of the preparation. the connections of this strip to the underlying mucosa are undisturbed. the preparation is immersed on the nutrient side in krebs-henseleit solution, gassed with 95% o2 and 5% co2, and the secretory side contains 5% dextrose, both at 37 degr ... | 1978 | 629348 |
| influenza in ferrets and guinea pigs: effect on cell-mediated immunity. | two different animal models were studied to determine whether localized upper respiratory tract viral infection was associated with suppression of systemic cell-mediated immunity. during influenza infection in ferrets, there was no significant decrease in lymphocyte responsiveness to phytohemagglutinin (pha). guinea pigs given influenza showed no significant change in their response to pha or to picryl human serum albumin (pichsa), to which they had been immunized previously. delayed hypersensit ... | 1978 | 631888 |
| simultaneous measurement of gastric secretion and motility in response to various stimuli in the ferret [proceedings]. | | 1978 | 633152 |
| growth and development of the european ferret (mustela putorius). | body weight, body length, and other developmental parameters were studied in the european ferret, mustela putorius, from birth to 26 weeks of age. males and females did not differ in weight until the seventh week of live, and they did not differ in length until the ninth week of life, when the males began to grow faster. adult males (1400--1500 g) were heavier than adult females (800--900 g), but females reached adult size faster than males. | 1978 | 633841 |
| histology and mucosubstance histochemistry of mongoose salivary glands. | the histology and mucosubstance histochemistry of the mongoose salivary glands were studied. histologically, the mongoose salivary glands were generally similar to those in other carnivores (dog, cat and ferret). the mucosubstance histochemistry demonstrated considerable variations in the parotid, submandibular and sublingual glands in comparison to the other carnivores. the partoid gland contained carboxylated mucin which was sialidase-resistant. granules in a few cells also contained sulphated ... | 1978 | 636829 |
| specific immunity to influenza virus in ferret organ cultures. | ferret tracheal organ cultures prepared from animals previously infected intranasally with influenza a virus required approximately 130 times more homologous virus (a/pr/8/34(hon1) or a/port chalmers/1/73 (h3n2)) to become infected in vitro than similar cultures from normal ferrets. also, these cultures from convalescent ferrets required 9 times more heterologous virus (a/pr/8/34(hon1) or sendai) to become infected in vitro than similar cultures from normal animals challenged in vitro with the h ... | 1978 | 638028 |