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hematological data of the laboratory-maintained bonnet (macaca radiata) and the langur (presbytis entellus entellus) monkeys. 197895998
antibody response of monkeys (macaca radiata) to sathuperi virus. 197796014
alcohol self-administration in monkeys (macaca radiata): the effects of prior alcohol exposure.responding by 4 monkeys was maintained under a fixed ratio 10 (fr 10) schedule for either food, intravenous sucrose or alcohol. the 20 hr sessions were divided so that food was available during hours 1, 6, 11, 16 and alcohol or sucrose during hours 2-5, 7-10, 12-15, and 17-20. all animals failed to maintain responding for isocaloric sucrose but continued to respond for food during those sessions. responding under alcohol conditions was positively accelerated in 2 animals that were not previously ...197897675
passive immunization with an antibody to the beta-subunit of ovine luteinizing hormone as a method of early abortion--a feasibility study in monkeys (macaca radiata).antiserum to the beta-subunit of ovine luteinizing hormone (olh-beta) raised in monkeys (macaca radiata) has been tested by a variety of criteria both in vivo and in vitro to establish its ability to neutralize olh, hlh, and human chorionic gonadotropin (hcg). passive administration of this antiserum caused inhibition of ovulation and termination of pregnancy in recipient monkeys as indicated by premature vaginal bleeding and a significant reduction in serum progesterone and estrogen levels. the ...197898358
heterologous radioimmunoassay systems for measurement of follicle stimulating hormone (follitropin) & luteinizing hormone (lutropin) in the bonnet monkey macaca radiata. 197898429
respiratory mechanics in normal bonnet and rhesus monkeys.we measured lung volumes and quasi-static volume-pressure relationships in 22 normal upright bonnet (macaca radiata) and 12 rhesus (m. mulatta) monkeys. in comparison with interspecies pulmonary function/body weight regressions our monkeys' lung volumes are larger and their lungs are considerably more compliant, but their chest wall compliance is similar to a wide range of mammalian species. however, chest wall compliance of our monkeys was found to be considerably less than that of other more c ...1979110757
flow-volume curves and total pulmonary resistance in normal bonnet and rhesus monkeys.we measured expiratory flow-volume curves and total pulmonary resistance in 15 normal, anesthetized, upright bonnet (macaca radiata) and 8 rhesus (m. mulatta) monkeys. absolute maximum flows are about half that found in humans, but, if expressed in vital capacities per second, monkey flows are about four times that of humans. however, irrespective of flow rate, the typical shape of maximum expiratory flow-volume (mefv) curves of rhesus monkeys is similar to that of normal young adults and that o ...1979110758
studies on insulin secreted by isolated islets of the monkey, macaca radiata radiata.the effects of various experimental conditions during the isolation of monkey islets by the collagenase method on the insulinogenic response of the isolated islets to glucose have been studied and compared with rat islets isolated under similar conditions. the monkey islets gave a normal response for at least 120 min. the results are compared with available studies on primate islets.1979111984
teratogenic effects of hyperthermia in the bonnet monkey (macaca radiata). 1979112705
initiation of menstrual cyclicity in laboratory maintained bonnet (macaca radiata) & langur (presbytis entellus entellus) monkeys. 1979116960
effect of passive immunization with specific antiserum to fsh on the spermatogenic process and fertility of adult male bonnet monkeys (macaca radiata). 1979118251
homologues of the human a, b, o & m, n blood groups in macaca radiata (geoffroy) & presbytes entellus (dufresne) & the reaction of their erythrocytes with lectins. 1979120312
semen analysis & hormonal levels in bonnet macaques administered embelia ribes berries, an indigenous plant having contraceptive activity. 1979120847
perception of conspecific vocalizations by japanese macaques. evidence for selective attention and neural lateralization.japanese macaques (macaca fuscata) and control species (vervet, pigtailed macaque, bonnet macaque) were trained for food to respond to one class of recorded fuscata vocalizations and do not respond to a second class. a measure of neural lateralization was obtained by presenting the stimuli randomly to the right or the left ear, and comparing performance in the two ears (ear advantage method). vocalizations were from steven green's field tapes. in experiment i, the two classes were green's 'smoot ...1979399204
purification, properties, and partial structure elucidation of a high-molecular-weight glycoprotein from cervical mucus of the bonnet monkey (macaca radiata).a high-molecular-weight glycoprotein has been purified from the cervical mucus of the bonnet monkey (macaca radiata). the glycoprotein was shown to be homogeneous by electrophoresis, sedimentation equilibrium, and n-terminal group determination, and to contain 19% protein, 19% d-galactose, 18% n-acetyl-d-galactosamine, 15% n-acetyl-d-glucosamine, 11% l-fucose, 10% sialic acid, and 1% sulfate groups, corresponding to about 1800 amino acid residues and 400 carbohydrate side chains of about 9 monos ...1977402940
changes in the sialic acid concentration in the major cervical glycoprotein from the bonnet monkey (macaca radiata) during a hormonally induced cycle.the major macromolecular component of monkey cervical mucus has been purified from crude monkey cervical mucus at various times during a hormonally induced estrous cycle. the major component, a high-molecular weight glycoprotein, was secreted in large amounts in midcycle mucus. the glycoprotein exhibited human blood group b activity and contained the same concentration of l-fucose, d-galactose, n-acetyl-d-galactosamine, and n-acetyl-d-glucosamine during the cycle. there were no changes in the am ...1977405259
brain acetylcholinesterase activity and multiplicity in the bonnet monkey (macaca radiata) and the rhesus monkey (macaca mulatta). 1977405458
factionated x-radiation damage to developing ovaries in the bonnet monkey (macaca radiata). 1977408865
measurement of hemolytic complement and the third component of complement in nonhuman primates.complement, determined by hemolytic assay, and the third component of complement (c3), determined by radial immunodiffusion assay, were measured in nine nonhuman primate species. the species studied were the titi (callicebus mollach). the sooty mangabey (cercocebus atys), the thick-tailed galago or bushbaby (galago crassicaudatus panganiensis), the crab-eating monkey (macaca fascicularis), the rhesus monkey (macaca mulatta), the bonnet monkey (macaca radiata), the stumptailed macaque (macaca spe ...1977414024
midcycle ovarian histology of the bonnet monkey, macaca radiata. 1978418824
spermiation and epididymal maturation of spermatozoa in the bonnet macaque (macaca radiata) as viewed by scanning electron microscopy.spermiation and epididymal maturation of spermatozoa were studied in the bonnet monkey (macaca radiata) by light and scanning electron microscopy. the morphology, location, and release of residual body were observed during spermiation. along the epididymal duct, the shape of spermatozoa changed, the constriction at the anulus disappeared, the marginal thickening diminished in length, and the cytoplasmic droplet regressed and moved toward the posterior end of the middle piece. mature spermatozoa ...1975803037
cyclic changes in the metabolism of glycogen in cervical mucus of bonnet monkeys (macaca radiata). 1975803283
intrapulmonary airway morphology in three species of monkeys: a correlated scanning and transmission electron microscopic study.intrapulmonary airways were studied in rhesus (macaca mulatta), stumptail (macaca arctoides), and bonnet (macaca radiata) monkeys by correlated scanning and transmission electron microscopy. lobar, segmental, and subsegmental bronchi in all three macaques were lined by pseudostratified columnar epithelium composed primarily of ciliated cells, mucous cells, and basal cells. neuronal processes and cells containing dense-core vesicles were also observed. terminal bronchioles in bonnet and stumptail ...1975804810
monkey motor stimulation and altered social behavior during chronic methadone administration.to assess the effects of chronic methadone administration on locomotor, social, and eating behavior od drug-native individuals under circumstances approximating those of methadone "maintenance" clinics, we gave single, daily oral doses of methadone to 5 macaca radiata monkeys living in a social group. we obtained motor activity counts automatically during 6 weeks of baseline, 10 weeks of drug administration, and 3 weeks of post-drug abstinence. social behaviors of association, dominance, submiss ...1975810820
increased collagen and glycoprotein contents of the denervated cremaster muscle of the bonnet monkey, macaca radiata.denervation of genitofemoralis in the bonnet monkey for 60 days resulted in a significant increase in neutral salt-soluble, alkali-soluble and insoluble collagens as well as glycoproteins. the hydroxyproline content of the salt-soluble and insoluble collagens in the muscle increased on denervation. these changes are discussed to imply the impairment of the action of specific structural genes.1975814015
the immunosuppressive effect of concanavalin a in monkeys.these studies were performed to evaluate the immunosuppressive effect of concanavalin a (cona) in monkeys. bonnet monkeys (macaca radiata) weighing between 2.5-3.5 kg were used. following the exchange of full thickness skin allografts in randomly selected animals, gross and histopathological studies of the rejection reaction were performed. gross observations showed the allograft reaction in control animals to be a well defined phenomenon occurring at 9.0 +/- 0.7 days. in contrast the rejection ...1976818753
follicle counts in the ovary of the bonnet monkey (macaca radiata). 1975820581
blood groups of bonnet macaques (macaca radiata), with a brief introduction to seroprimatology.the human-type a-b-o blood groups of 52 bonnet macaques (macaca radiata) were determined. application of method of population genetics indicated the gene frequences to be 0 = 0.173, a = 0.480 and b = 0.347. cross testing of sera and red cells of the bonnet macaques revealed two blood-type-specific isoagglutinins, one of them strong enough for use as a blood typing reagent. no blood group polymorphism was revealed by testing bonnet macaque red cells with isoantisera produced in rhesus monkeys (m. ...1976826172
radiation-induced fetal testicular damage in the monkey (macaca radiata).the testes of five monkeys (macaca radiata) were examined histologically for evidence of damage, following in utero fractionated x-irradiation. radiation-induced damage was found in the testes of animals beginning at total exposures of 170 r, when compared to controls.1976826635
ultrastructure of testes and excurrent ducts in the bonnet monkey (macaca radiata).the testes and excurrent ducts of four bonnet macaques (macaca radiata) were examined using scanning and transmission electron microscopy. the three layers of contractile and connective tissue composing the tunica albuginea, and the multilayered tunica propria of the seminiferous tubules were similar to that of man. spermatids project from the epithelium or are found free in the lumen. the stages of the cycle of the germinal epithelium in the bonnet macaque were similar to that in other macaques ...1976828929
failure to produce atherosclerosis in macaca radiata on a high-methionine, high-fat, pyridoxine-deficient diet.accelerated atherosclerotic lesions are observed in genetic defects characterised by marked homocystinaemia as a result of low levels of cystathionine synthase, a pyridoxal phosphate-dependent enzyme. attempts were therefore made to induce atherosclerosis in macaca radiata, maintained on a high-protein, high-methionine and high-fat diet by inducing pyridoxine deficiency with deoxypyridoxine. pyridoxine deficient monkeys failed to show any biochemical or pathological evidence of atherosclerosis, ...1977901621
termination of pregnancy in macaques (macaca radiata) using monkey antiserum to ovine luteinizing hormone. 19751139954
teratologic evaluation of imipramine hydrochloride in bonnet (macaca radiata) and rhesus monkeys (macaca mulatta).imipramine hydrochloride was administered orally twice daily to 18 bonnet and 3 rhesus monkeys between days 23 and 45 of pregnancy for 1-3 or 18-22 days at 1, 2, and 10 times the recommended human dose. no teratologic changes were observed, although signs of maternal toxicity occurred at the high dose level, and the abortion rate was higher than in controls.19751154287
role of prolactin on epididymal glycoprotein metabolism in matured monkeys, macaca radiata: specific activities of glycosyltransferases and glycosidases.impact of altered serum prolactin status on enzymes involved in glycoprotein metabolism in epididymal tissue of matured monkeys was studied. hyperprolactinemia (ovine prolactin-250 micrograms/kg body weight/day for 30 days) significantly inhibited the specific activities of dolichylphosphate mannosyl transferase, dolichylphosphate glucosyl transferase and galactosyl transferase, in the epididymal tissues. however, it had an enhanced effect on epididymal glycosidases such as beta-galactosidase, b ...19921293032
ability of deglycosylated human chorionic gonadotropin (dghcg) to block luteal function and establishment of pregnancy in bonnet monkeys (macaca radiata).the ability of deglycosylated hcg (dghcg) prepared by deglycosylation of a clinical hcg (3000 iu/mg) preparation, to block luteal function during regular cycles as well as luteal rescue in simulated and mated cycles of female bonnet monkeys (m. radiata) has been evaluated. the cycle length (c:28 vs e:24 days) and the total progesterone produced during the luteal phase was significantly reduced (by 45%, p < .05) by injecting 450 micrograms of dghcg/day (in split doses) on days 18, 19, and 20 of c ...19921293044
ultrastructural specialization of intestinal epithelium over peyer's patches in the bonnet monkey, macaca radiata.the follicle associated epithelium (fae) which separates the lymphoid follicle of peyer's patch from the gut lumen is known to have specialized cells called m cells or "microfold" cells in man and certain animals. these cells are considered to be involved in antigen uptake and transport. our light microscopic study of the small intestine of bonnet monkeys suggested the presence of such specialised cells in fae. we have confirmed the presence of m cells in bonnet monkey fae having ultrastructural ...19921294477
infection of macaca radiata with viruses of the tick-borne encephalitis group.our studies confirmed the susceptibility of macaca radiata (bonnet macaques) to kyasanur forest disease (kfd) and enabled us to demonstrate kfd virus-specific gastrointestinal and lymphoid lesions. significant histopathological changes occurred in the small and large intestine, spleen and lymph nodes; and viral antigens were found in these same organs by immunohistochemistry. viral antigen-positive cells were always associated with histological evidence of necrosis, which suggests that cell deat ...19921297916
ulnar nerve inoculation of poliovirus in bonnet monkey: a new primate model to investigate neurovirulence.a new monkey model of poliovirus neurovirulence has been developed avoiding the currently used intraspinal injection route which traumatizes the spinal cord. poliovirus type 1 (0.1 ml) was inoculated into the ulnar nerve of bonnet monkeys (macaca radiata) at the right elbow. five monkeys were inoculated with 10(7) tcid of lsc/2ab (sabin vaccine strain); none developed any illness. limb paralysis, clinically resembling spinal poliomyelitis in children, developed in all four monkeys given greater ...19921320307
two-way cross-protection between west nile and japanese encephalitis viruses in bonnet macaques.cross-protection between japanese encephalitis (je) and west nile (wn) viruses was tested in bonnet macaques (macaca radiata) immunized either with je virus (jev) or wn virus (wnv). jev immunized monkeys were challenged by intranasal (i.n.) route with wnv and vice versa. four control unimmunized monkeys were similarly infected either with wnv or jev. two of three control monkeys infected with wnv, developed paralysis followed by death. virus was recovered from the central nervous system (cns) of ...19921360756
effects of prolactin and androgens on enzymes of carbohydrate metabolism in prostate of castrated bonnet monkeys macaca radiata (geoffroy).effects of prolactin (prl), bromocriptine (br), testosterone propionate (tp), dihydrotestosterone (dht) and the combinations of these androgens with prl/br on the specific activities of caudal and cranial prostatic cellular enzymes involved in carbohydrate metabolism in castrated mature bonnet monkeys have been studied. castration decreased all the enzymes studied such as hexokinase (hk), 6-phosphofructokinase (6-pfk), glyceraldehyde-3-phosphate dehydrogenase (g-3-pd), pyruvate kinase (pk), gluc ...19921387111
long-term contraceptive efficacy of vaccine of ovine follicle-stimulating hormone in male bonnet monkeys (macaca radiata).a group of ten healthy fertile adult male bonnet monkeys were actively immunized using procedures acceptable for human use with pure follicle-stimulating hormone (ofsh) isolated from sheep pituitaries. the vaccine elicited an immunogenic response in all ten monkeys; the antibody-binding capacity, determined by scatchard analysis, varied from 3 to 18 micrograms ofsh ml-1, the binding affinity ranging from 0.13 to 2.0 x 10(10) mol-1. a substantial population of antibodies against ofsh crossreacted ...19921432977
sperm production and fertility of bonnet monkeys (macaca radiata) following immunization with ovine follicle stimulating hormone.adult male bonnet monkeys were rendered oligospermic but not azoospermic following active immunization with ovine follicle stimulating hormone. the percentage of sperms in the semen having good motility was reduced with a concomitant increase in the sperm atpase activity. eight out of 10 immunized monkeys failed to impregnate females of proven fertility after mating for consecutive three cycles while the remaining two impregnated the cohabitated females during the third cycle at a time when the ...19921459629
microscopic anatomy of small intestine of macaca radiata with special reference to gut associated lymphoid tissue.the hitherto unreported microscopic anatomy of the small intestine of the bonnet monkey (m. radiata) was studied. there was a striking similarity in the general structure and cellular composition of the small intestine of the animal and that of humans. of special interest was our observation of the occurrence of cells interspersed in the follicle associated epithelium which were morphologically similar to human m cells. these cells were pale, devoid of a brush border and frequently had lymphocyt ...19921506026
interaction of androgens and prolactin on prostatic enzymes of the pyruvate-malate cycle involved in lipogenesis in castrated mature monkey, macaca radiata.effects of androgens, prolactin (prl) and bromocriptine (br) on the specific activities of prostatic (caudal and cranial) enzymes of the pyruvate-malate cycle were studied in castrated mature bonnet monkeys. castration decreased the activity of nadp+ isocitrate dehydrogenase (icdh), atp citrate lyase, malate dehydrogenase (mdh), malic enzyme and fatty acid synthase (fas). administration of testosterone propionate (tp)/dihydrotestosterone (dht) increased the activities of all these enzymes in bot ...19921511627
isolation of a tripeptide (ala-gly-ser) exhibiting weak acetylthiocholine hydrolyzing activity from a high-salt soluble form of monkey diaphragm acetylcholinesterase.a high-salt soluble form of acetylcholinesterase (ache) was purified from monkey (macaca radiata) whole diaphragm by a two step affinity chromatographic procedure using m-aminophenyl trimethylammonium-chloride hydrochloride-sepharose and procainamide-sepharose columns. the purified enzyme showed three major protein bands at 80 kda, 78 kda and 60 kda on sds-gel electrophoresis. [3h]diisopropyl fluorophosphate ([3h]dfp) labeled enzyme also gave three radioactive peaks corresponding to these three ...19921513418
interference with ovulation and luteal function by human ovarian follicular fluid peptide in bonnet monkeys, macaca radiata.partially purified human ovarian follicular fluid peptide (hgf2) was administered during follicular phase in 5 bonnet monkeys. in control as well as hgf2-injected animals, ovulation was synchronized by treatment with fsh, pergonal and hcg. all the 5 control bonnet monkeys showed plasma estradiol peak followed by increased progesterone levels. in 4 out of 5 hgf2-injected animals, plasma progesterone levels were drastically reduced. plasma estradiol levels were decreased only in 3 animals in which ...19921516370
effects of sts-557 and 20 aet-1 on sperm functions and serum level of testosterone in bonnet monkey (macaca radiata).treatment of adult male bonnet monkeys with sts-557 (17 alpha-cyanomethyl 17 beta-hydroxy estra-4, 9(10)-dien-3-one; 12 mg/monkey daily for 15 weeks; i.m.) reduced the sperm count from the 9th week, leading close to azoospermia on the 2nd post-treatment week which persisted until the 10th post-treatment week and normalcy was restored on the 13th post-treatment week. the sperm motility was reduced from the 9th week of treatment to 8th post-treatment week. the fertilizing ability of spermatozoa (f ...19921623719
vasculopathic and cardiomyopathic changes induced by low-protein high-carbohydrate tapioca based diet in bonnet monkey. vasculopathic and cardiomyopathic changes in induced malnutrition.mucoid vasculopathy is an entity characterized by a generalized mucopolysaccharidosis of blood vessels. it has been observed in patients from our institute. bonnet monkeys (macaca radiata) were given low-protein normal-carbohydrate and low-protein high-carbohydrate tapioca based diets for experimental periods of 3 or 5 months. the latter diet is similar to that consumed by people from this part of india (kerala) where mucoid vasculopathy is observed. vascular lesions were seen in all test animal ...19921627329
chronic suppression of testicular function by constant infusion of gonadotropin-releasing hormone agonist and testosterone supplementation in the bonnet monkey (macaca radiata).to study the efficacy of long-term buserelin acetate infusion to desensitize pituitary and block testicular function in adult male monkeys (macaca radiata).19921740216
cardiovascular effects in bonnet monkeys (macaca radiata) of a cassava-based protein-deficient diet.bonnet monkeys (macaca radiata) were maintained for up to 5 mo on protein-deficient diets that contained tapioca starch (cassava starch) as the source of carbohydrate. the animals developed mucopolysaccharidosis of blood vessels and cardiomyopathic changes in the heart. these changes were similar to the mucoid vasculopathy and cardiomyopathy seen in kerala where tapioca is consumed as a staple diet by a large proportion of the people. the lesions were enhanced by longer duration of feeling the d ...19911746130
influence of prolactin on pulmonary lipids in mature male bonnet monkey, macaca radiata.administration of ovine prolactin (250 micrograms/kg body weight/day) for 30 days to mature male bonnet monkeys increased the pulmonary total lipids and total phospholipids. while total cholesterol did not show any appreciable change in prl treated monkeys, the ratio of free: esterified cholesterols was altered with perceptible decrease in free cholesterol and increase in esterified cholesterol. pulmonary tissue total glyceride glycerol concentration was diminished as a result of decreased monoa ...19911794894
role of prolactin on leydig, sertoli and germ cellular neutral lipids in bonnet monkeys, macaca radiata.to elucidate the specific influence of prolactin on neutral lipids in leydig, sertoli and germ cell compartments of the testis in immature and mature monkeys, the present study was carried out by injecting ovine prolactin (oprl) (1 mg/kg body weight/twice daily for 10 days ip), to both age groups. similarly, bromocryptine (an ergot alkaloid which inhibits prolactin secretion) was given to other sets of immature and mature monkeys (1 mg/kg body weight/twice daily for 10 days ip) to induce hypopro ...19911804126
relationship between testosterone and hepatic lipids in mature male bonnet monkeys, macaca radiata (geoffroy).administration of testosterone propionate (tp; 1 mg/kg body weight/day; im, for 30 days) to mature male bonnet monkeys, decreased total lipids, glyceride glycerol and cholesterol concentrations in hepatic tissue. the decrease in glyceride glycerol was due to decrease in monoacyl and triacyl glycerol. both, free and esterified cholesterol were decreased after testosterone administration. eventhough, total phospholipid was not significantly altered, phosphatidylserine and cardiolipin were increase ...19911816100
isolation of a tripeptide showing weak acetylthiocholine hydrolysing activity from a soluble form of monkey basal ganglia acetylcholinesterase by limited trypsin digestion.acetylcholinesterase was purified from the soluble supernatant of monkey (macaca radiata) brain basal ganglia by a three-step affinity purification procedure. the purified enzyme showed two major protein bands corresponding to molecular weights of approximately 65 kda and approximately 58 kda which could be labelled by [3h]diisopropylfluorophosphate. when the purified enzyme was subjected to limited trypsin digestion followed by gel filtration on sephadex g-75 or sephadex g-25 column, a peptide ...19911879867
comparative analyses of age- and sex-specific patterns of vocal behaviour in four species of old world monkeys.sound recordings and behavioural data were collected from four primate species of two genera (macaca, presbytis). comparative analyses of structural and behavioural aspects of vocal communication revealed a high degree of intrageneric similarity but striking intergeneric differences. in the two macaque species (macaca silenus, macaca radiata), males and females shared the major part of the repertoire. in contrast, in the two langurs (presbytis johnii, presbytis entellus), many calls were exclusi ...19911885113
studies on cytosolic superoxide dismutase from intestinal mucosa.cuzn superoxide dismutase from monkey (macaca radiata) intestinal mucosa was purified to homogenity. the enzyme showed a subunit molecular weight of 16000. the enzyme preparation from intestinal mucosa of rat, rabbit, guinea-pig and monkey was distinctly different in electrophoretic mobility and in elution profile on ion-exchange chromatography, possibly due to their difference in charge. the difference may not be due to glycosylation, since the enzyme was not stained for glycoprotein. polyclona ...19911905269
use of adult male bonnet monkeys (macaca radiata) for testing the biological activity of gonadotropin releasing hormone and its analogues.the effect of injecting agonistic and antagonistic analogues of gonadotropin releasing hormone analogues on serum testosterone levels was checked in adult and immature male bonnet monkeys. of the agonistic analogues buserelin, ovurelin and d-phe6 gln8 gnrh were found to be most potent in increasing serum testosterone levels in the adult male bonnet monkeys. while 27-month-old monkeys responded well to des gly10 gnrh, only marginal response was observed in the case of 15-month-old monkeys. studie ...19911910269
attachment in monkey infants raised in variable- and low-demand environments.12 bonnet macaque (macaca radiata) mother-infant dyads were studied. for 14 weeks, beginning when the infants were a mean age of 11.2 weeks, the dyads were housed and observed under different foraging-demand conditions for the mothers: 6 dyads in a low-foraging-demand (lfd) condition and 6 dyads in a variable-foraging-demand (vfd) conditions. for vfd mothers, demand varied between low and high in 2-week blocks. differences between the lfd and vfd groups were minimal during this period; there was ...19911935339
protective effect of 6-mfa, a fungal interferon inducer against japanese encephalitis virus in bonnet macaques.6-mfa, an extract from the fungus aspergillus ochraceus was administered to 8 bonnet macaques. an equal number of monkeys matched for age, sex and weight received placebo and served as controls. twenty hours after the administration of the 6-mfa/placebo the monkeys were challenged with an indian strain of japanese encephalitis virus by the intranasal route. signs and symptoms of the disease such as fever, tremors, loss of appetite, dehydration, flaccid paraplegia or quadriplegia were pronounced ...19901965430
prostatic hypoplasia in bonnet monkeys following active immunization with semisynthetic anti-lhrh vaccine.an active immunization study using semisynthetic anti-luteinizing hormone releasing hormone (lhrh) vaccine was undertaken in adult male bonnet monkeys (macaca radiata). four male bonnet monkeys were immunized with lhrh-dt vaccine (100 micrograms/monkey). when the elevation of serum anti-lhrh titers reached an effective concentration, a remarkable decrease in serum testosterone level was observed. the sperm counts at 12 and 20 weeks following immunization in all immunized monkeys were reduced mar ...19912060609
luteal-phase defect induced by deprivation of fsh at a specific period of the follicular phase prevents pregnancy in the bonnet monkey (macaca radiata).female bonnet monkeys were injected i.v. with 25 microliters antiserum to fsh on days 5, 6 or 7 of the cycle: the length of the luteal phase was shortened but there was no alteration in cycle length. proven fertile females (n = 6) were caged throughout the period of the experiment (6 cycles) with proven fertile males and treated with 25 microliters fsh antiserum on day 7 of each of 3 successive cycles. out of 18 cycle exposures during the treatment phase, 17 were ovulatory, but no pregnancies oc ...19902107302
effect of modulating endogenous prolactin secretion on testosterone production in the adult male bonnet monkey (macaca radiata).adult male bonnet monkeys maintained under regulated light: dark conditions exhibit a nycthemeral surge of testosterone. the present study attempts to determine the effect of administration of drugs that modulate prolactin levels like ergobromocriptine (ebc) and chlorpromazine (cpz) on testosterone production. the injection of ebc, a known inhibitor of prolactin secretion, could abolish nocturnal testosterone surge irrespective of the drug being given at 8.00 or 17.00 h. testosterone surge could ...19902122770
effect of constant infusion of gonadotropin releasing hormone (gnrh) agonist buserelin and antagonist cdb 2085 a using osmotic minipumps on testicular function in adult male bonnet monkey (macaca radiata).the effect of chronic infusion of gonadotropic hormone agonist buserelin or antagonist cdb 2085 a for 15 weeks via alzet minipumps in adult male bonnet monkeys was studied. infusion of buserelin resulted in a decrease in the difference between serum testosterone values at 22.00 hours and 10.00 hours, decrease in responsiveness to injected buserelin as judged by change in serum testosterone values from pre-injection values and decrease in sperm counts. infusion of antagonist resulted in a decreas ...19902129183
influence of prolactin, androgens and bromocriptine on seminal vesicular and prostatic adenosine triphosphatases in castrated adult monkeys macaca radiata.e ects of prolactin (prl), bromocriptine (br), testosterone propionate (tp), dihydrotestosterone (dht) and the combinations of these androgens with prl/br on specific activities of adenosine triphosphatases (atpases) of seminal vesicles and cranial and caudal prostates were studied in castrated adult bonnet monkeys. castration decreased all atpases (sodium/potassium, magnesium and calcium dependent) of seminal vesicles and both the lobes of prostate. prl restored the normal activities of all atp ...19902151573
the retinohypothalamic projection and oxidative metabolism in the suprachiasmatic nucleus of primates and tree shrews.this study compared the patterns of retinal projections and oxidative metabolism in the hypothalamus of squirrel monkeys, bonnet macaques, and tree shrews. intraocular injections of horseradish peroxidase in primates demonstrated that retinal terminals were present from the anterior to posterior poles of the suprachiasmatic nucleus (scn). the terminals were primarily located in the ventral and ventrolateral regions of the scn. in addition, there was a relatively even density and distribution of ...19902169949
effect of a specific estrogen antibody on pregnancy establishment in the bonnet monkey (macaca radiata).the requirement for estrogen for pregnancy establishment has not been conclusively demonstrated in primates. selective neutralization of estrogens was achieved in mated female monkeys during preimplantation and postimplantation periods by injecting characterized estrogen antiserum from either day 14 to 18 or day 28 to 32 of cycle. while estrogen deprivation during preimplantation period in 5 animals exposed to 14 ovulatory cycles resulted in only one pregnancy, only 3 of 13 monkeys treated durin ...19902245844
studies on cervical glycoproteins. isolation and characterization of neutral oligosaccharides from pronase-treated glycoproteins of bonnet monkey (macaca radiata). 19902276149
impact of hyperprolactinaemia on testicular neutral lipids and phospholipids in mature bonnet monkeys, macaca radiata (geoffroy).impact of hyperprolactinaemia, induced by daily injection of ovine prolactin (250 micrograms/kg body weight, ip for 30 days) on testicular lipids was studied in m. radiata. wet weights of testis and accessory sex organs decreased in hyperprolactinaemic monkeys. even though total lipids in the testis did not show any significant change, total cholesterol and total glyceride glycerol decreased. while all fractions of testicular neutral lipids showed a perceptible decrease, phosphatidic acid, phosp ...19902279784
effect of bmy 21502 on acquisition of shape discrimination and memory retention in monkey.bmy 21502 is a novel pyrrolidinone nootropic with demonstrated ability to reverse electroconvulsively induced amnesia in rodents. we administered bmy 21502 intramuscularly to four monkeys (macaca radiata) during testing using two separate paradigms. the first test involved the acquisition of a visual shape discrimination task where each monkey learned to select the correct lighted panel. in the second task, memory retention was tested by having the monkeys select and press the correct lighted pa ...19902339147
contraceptive potentiality of sts-557--a feasibility study in male bonnet monkey (macaca radiata).sts-557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4, 9(10)-diene-3-one) was administered (i.m.) to two groups (4 in each group) of adult male bonnet monkeys at a daily dose of 10 mg/monkey for 12 weeks (first group) and 5 mg/monkey for 14 weeks (second group). treatment with the 10 mg dose resulted in a significant decline in the count, motility, acrosin and hyaluronidase activities and the fertilizing ability (zona-free hamster egg penetration assay) of spermatozoa by the 6th week of initiati ...19902361371
dna flow-cytometric analysis of testicular germ cell populations of the bonnet monkey (macaca radiata) as a function of sexual maturity.testicular germ cell populations of biopsies from 32 male bonnet monkeys in 5 different age groups were quantitated in a flow cytometer after labelling of germ cell dna with the specific fluorochrome, 4,6-diamidino phenyl indole. the 5 quantifiable populations were spermatogonia (2c), preleptotene spermatocytes (s phase), primary spermatocytes (4c), round spermatids (1c) and elongate spermatids (hc). the seminiferous tubules of immature 3-4-year-old monkey had only sertoli cells and spermatogoni ...19902401971
effect of prolactin and androgens on the prostate of bonnet monkeys, macaca radiata: i. nucleic acids, phosphatases, and citric acid.the effects of prolactin (prl), bromocriptine (br), testosterone propionate (tp), dihydrotestosterone (dht), and the combinations of these androgens with prl/br on the growth and secretory activities of cranial and caudal prostates were studied in castrated mature monkeys, macaca radiata. castration decreased the body weight, organ weights, nucleic acids (dna and rna), phosphatases, and citric acid of cranial and caudal prostates. prl did not alter the body weight but increased the organ weights ...19872438674
muscle receptors: content of some of the extrinsic and intrinsic muscles of the larynx in the bonnet monkey (macaca radiata).the number of muscle receptors and in particular the muscle spindle content of some of the intrinsic and extrinsic laryngeal muscles was evaluated, using bonnet monkeys (macaca radiata). the technique of barker and ip [j. physiol. (lond) 169:73-74, 1963] was used to stain the muscle receptors. the results indicate that the intrinsic laryngeal muscles were devoid of muscle spindles. the extrinsic laryngeal muscles that were examined contain muscle spindles, though their density is less than that ...19892469361
effect of fsh deprivation at specific times on follicular maturation in the bonnet monkey (macaca radiata).cyclic monkeys were deprived of fsh for specific periods on different days of the follicular phase by injecting them with minimal doses of an fsh antiserum characterized for specificity and bioneutralizing ability. the effect of the antiserum on follicular maturation was assessed by determining (a) serum oestrogen concentrations through the midcycle period, (b) serum progesterone concentrations as an index of ovulation and luteal function, (c) laparoscopic examination of the surface of the ovary ...19892516132
intestinal immunity to poliovirus develops only after repeated infections in monkeys.to establish gut immunity in monkeys to polio-virus type 1, we fed four juvenile bonnet monkeys (macaca radiata) with 100 median infectious doses of the mahoney strain of virus. the duration of viral shedding in the throat and faeces and the titre of virus in faeces were measured. eighteen days after the last monkey stopped shedding virus, they were inoculated once again with the same amount of virus. all monkeys got re-infected; the duration and titres of viral shedding were very similar to tho ...19892537880
influence of prolactin on neural and glial cellular adenosine triphosphatases in immature male bonnet monkeys (macaca radiata, geoffroy).the effect of prolactin on specific activities of adenosine triphosphatases (atpases) in neural and gliar cells of cerebral cortex, cerebellum and pons-medulla of immature male bonnet monkeys was studied. na+, k+ dependent atpase was stimulated, while mg2+ and ca2+ dependent atpase activities showed reduction in neural as well as glial cells of cerebral cortex and cerebellum. however, in pons-medulla, na+, k+ and mg2+ dependent atpases showed the same trend in neural and glial cells, respectivel ...19892558073
a peptidase activity from primate liver that inactivates oxytocin in vitro: purification and partial characterization.an aminopeptidase from monkey (macaca radiata) liver, inactivating oxytocin in vitro and located predominantly in the lysosomal and microsomal fractions, was purified by chromatography on bio-gel htp, deae-sephacel and nickel ion chelate gel and gel filtration on sephacryl s300. absence of binding to nickel ion chelate gel indicated the absence of exposed histidine and thiol residues on the enzyme. the enzyme appeared to be a high molecular weight (mr 106,000) monomeric protein. it was sensitive ...19892754377
effects of prolactin and androgens on seminal vesicular lipids of castrated mature bonnet monkeys macaca radiata.effects of prolactin (prl), bromocriptine (br), testosterone propionate (tp), dihydrotestosterone (dht) and the combination of these androgens with prl/br on the total lipid, total cholesterol, total glyceride glycerols, total phospholipid and their fractions in seminal vesicles of castrated mature monkeys were studied. glyceride glycerols formed the major portion (50%) of total lipids in normal monkeys. cholesterol and phospholipids were of equal share (25%). esterified cholesterol formed major ...19892807413
prolactin and leydig cell steroidogenic enzymes in the bonnet monkey (macaca radiata).the effect of treatment with prolactin or bromocryptine on testicular steroidogenesis and serum hormone levels were studied in immature and mature bonnet monkeys. leydig cells alone showed the presence of 3 beta-hydroxysteroid dehydrogenase (3 beta-hsd) and 17 beta-hydroxysteroid dehydrogenase (17 beta-hsd) in normal immature and mature monkeys. administration of prolactin increased the activity of 3 beta-hsd and 17 beta-hsd in leydig cells from mature monkeys, and also increased the serum level ...19882833448
interactions of androgens and prolactin in the seminal vesicles of mature bonnet monkeys, macaca radiata. i. nucleic acids and phosphatases.the effects of prolactin (prl), bromocriptine, testosterone propionate (tp), dihydrotestosterone (dht), and the combinations of these androgens with prl or bromocriptine on nucleic acids (rna and dna) and phosphomonoesterases (acid and alkaline phosphatase) of the seminal vesicles of castrated mature bonnet monkeys were studied. castration decreased body weight, and seminal vesicle organ weight, nucleic acids and acid and alkaline phosphatases. tp/dht replacement to castrates restored body weigh ...19882838446
free fatty acids, lipid peroxidation, and lysosomal enzymes in experimental focal cerebral ischemia in primates: loss of lysosomal latency by lipid peroxidation.experimental focal cerebral ischemia was produced in monkeys (macaca radiata) by occlusion of the right middle cerebral artery (mca). the release of the lysosomal glycosidases, beta-d-hexosaminidase, alpha-l-fucosidase and alpha-d-mannosidase into the soluble fraction in the right basal ganglia of the experimental animals was measured at different periods from 30 min to 12 hr after occlusion and compared with the corresponding sham operated control animals. there was a significant increase in th ...19882968524
influence of follicle stimulating hormone on phosphomonoesterases and adenosine triphosphatases in the ovary of immature bonnet monkeys (macaca radiata, geoffroy). 19863028943
intestinal immunity induced by inactivated poliovirus vaccine.in order to detect any intestinal immunity against poliovirus infection induced by parenteral vaccination with inactivated poliovirus vaccine (ipv), experiments were conducted in monkeys (macaca radiata). all animals were seronegative (antibody not detected at 1:2 dilution of serum) before investigation. sixteen monkeys were vaccinated with three doses of ipv at monthly intervals. groups of four vaccinated and two seronegative control animals were fed 100 median monkey infectious doses (100 mid5 ...19873037815
taste preferences of squirrel monkeys and bonnet macaques for polycose, maltose and sucrose.the taste preferences of adult male squirrel monkeys and bonnet macaques for polycose, maltose, and sucrose solutions were compared in 24 hr/day solution vs. water tests. solution concentrations of 0.01 m, 0.05 m, 0.10 m, and 0.20 (polycose) or 0.50 m (maltose and sucrose) were tested. the squirrel monkeys displayed a stronger preference for sucrose than for maltose or polycose. in fact, at most concentrations tested, the squirrel monkeys did not consume more maltose or polycose than water. the ...19883237782
effects of androgens, prolactin and bromocriptine on seminal vesicular enzymes of the pyruvate malate cycle involved in lipogenesis in castrated mature monkeys, macaca radiata.the interaction of androgens and prolactin, the major factors regulating the male accessory sex organs, on the specific activity of seminal vesicular enzymes of the pyruvate/malate cycle were studied in castrated mature monkeys. castration decreased the activity of these enzymes, including nadp+ isocitrate dehydrogenase, atp citrate lyase, malate dehydrogenase, malic enzyme and fatty acid synthase. testosterone propionate (tp)/dihydrotestosterone given as replacement to castrates increased the a ...19883372045
oral tacrine administration in middle-aged monkeys: effects on discrimination learning.we studied the effect of chronic, oral administration of 1,2,3,4 tetrahydro-9-aminoacridine (tha), an anticholinesterase, on the acquisition of a color discrimination task in five monkeys (macaca radiata), aged 13-19 years. a two-phase experiment was performed: initially, one animal was used and served as his own control in a multiple dose, crossover, placebo controlled trial, designed to establish a dose-response curve and an optimal dose range based on tha serum concentrations. thereafter, fou ...19883374739
effects of sts 557 on semen and sperm functions in bonnet monkey (macaca radiata)--a preliminary report.intramuscular administration of sts 557 (17 alpha c-cyanomethyl-17 beta-hydroxy-estra-4,9(10)-diene-3-one) at a daily dose of 12 mg/monkey for 8 weeks induced severe oligospermia to complete azoospermia by the 9th week of initiation of treatment with concomitant decrease in the serum level of testosterone. the sperm motility was reduced from the 3rd week of treatment. complete recovery was observed by the 14th week after withdrawal of treatment. sts 557 may have the potentiality to be used as a ...19883396360
estrogen modulation of riboflavin carrier protein in the bonnet monkey (macaca radiata).circulatory concentrations of riboflavin carrier protein (rcp) were quantitated in bonnet macaques by employing a heterologous radioimmunoassay involving 125i-labelled chicken rcp and its antiserum. the levels of monkey rcp in the serum seem to be governed by the estrogenic status of the animals. an increase in concentration of serum estradiol in the adult females during the menstrual cycle and early pregnancy could be correlated with enhanced serum rcp levels. estadiol-17 beta administered to b ...19883398534
immunological cross-reactivity of antibodies with species chorionic gonadotropin is a critical requirement for efficacy testing of human gonadotropin vaccines in sub-human primates.a key question in the evaluation of a contraceptive vaccine is its efficacy in the prevention of pregnancy. primates have been employed for evaluation of the efficacy of candidate vaccines against human chorionic gonadotropin (hcg). discrepancies have been noted between the immuno-reactive antibody titres (against hcg) determined by ria and their ability to prevent pregnancy in test animals. to gain further information on factors involved in fertility control, other characteristics of antibodies ...19883418617
use of tamoxifen, an antioestrogen, in establishing a need for oestrogen in early pregnancy in the bonnet monkey (macaca radiata).administration of tamoxifen orally (3 mg/kg/day) during the post-ovulatory period from days 16 to 20 or from days 18 to 30 of female bonnet monkeys mated between days 9 and 14 of the cycle resulted in inhibition of pregnancy establishment in 90-100% of monkeys tested. the pregnancy establishment in control female monkeys after exposure to the male during one ovulatory cycle was 66%. the effect of tamoxifen was not due to interference with luteal function because there was no reduction in serum p ...19873430456
pregnancy suppression in the bonnet monkey by active immunisation with chicken riboflavin carrier protein.five healthy female bonnet monkeys (macaca radiata) of proven fertility and normal menstrual cyclicity have been actively immunised with the purified chicken egg white riboflavin carrier protein (crcp). all the immunised animals exhibited specific antibodies to crcp and the immunopotencies of their sera varied from 200 to 840 micrograms/ml at equivalent point. a definite fraction of antibodies in these sera specifically recognised the purified and 125i-labelled monkey rcp. immunisation per se ha ...19873430484
the epizootics of kyasanur forest disease in wild monkeys during 1964 to 1973.in the kyasanur forest disease area two species of wild monkeys, presbytis entellus and macaca radiata, succumb to the natural infection with kyasanur forest disease (kfd) virus (family flaviviridae). between october 1964 and september 1973, 1046 monkeys (860 p. entellus and 186 m. radiata) died. of these, kfd virus was isolated from 118 p. entellus and 13 m. radiata. maximum mortality of monkeys was reported during december through may coinciding with the season of activity of immature stages o ...19863603621
changes in the content of dopamine and its metabolites in the basal ganglia following right middle cerebral artery occlusion and reflow in monkeys.focal ischaemia was produced experimentally in macaca radiata monkeys by occlusion of middle cerebral artery (mca). there was a lowering of the dopamine (da) content of basal ganglia after 4 and 12 h of occlusion. da content was restored to normal in basal ganglia after restoration of blood flow. with the progress of time the da content was increased above that of sham controls. changes were also observed in the non-occluded left basal ganglia. the homovanillic acid (hva) content was decreased s ...19873608238
purification of a circulatory riboflavin carrier protein from pregnant bonnet monkey (m. radiata): comparison with chicken egg vitamin carrier.a specific protein exhibiting immunological cross-reactivity with chicken egg-white riboflavin carrier protein was detected by radioimmunoassay in the pregnancy sera of bonnet monkeys (macaca radiata). this protein, which is capable of binding [14c]riboflavin, was purified by gel filtration on sephacryl s-300, fast protein liquid chromatography on a mono q anion exchanger and chromatofocusing on mono p columns. the isolated primate carrier protein was similar to its avian counterpart in terms of ...19873651467
interactions among motility, fertilizing ability, and testosterone binding on spermatozoa of bonnet monkey (macaca radiata).fresh ejaculates of bonnet monkeys were separated into fractions rich with highly motile and sluggishly motile spermatozoa. the motility, ability to fertilize zona-free hamster eggs, and distribution of testosterone-binding sites on spermatozoa were assessed to determine the relation between these sperm functions. two parameters of objective assessment of motility--velocity and degree of flagellar bending--were significantly correlated with the ability to form pronuclei in zona-free hamster eggs ...19863741025
sound localization of frequency-modulated sinusoids by old world monkeys.directional hearing acuity, as measured by the minimum audible angle (maa), was determined in four old world monkeys, macaca radiata. the acoustic stimuli were linear changes in frequency (sweeps) for different frequency ranges and sweep rates. the sweeps ranged between 0.5 and 1.3 khz, at two durations, 100 and 200 ms. in upsweeps which began at 0.5 khz and were 200 ms in duration, maa decreased as sweep rate and frequency range increased. these thresholds were compared to maas of sweeps which ...19863760331
linear-lumped-parameter modeling of pulmonary impedance in monkeys.pulmonary impedance, zl, measured from 2 to 32 hz in anesthetized, intubated and paralyzed bonnet monkeys (macaca radiata) was fitted to a variety of linear-lumped parameter mechanical networks. parameter values for each network were obtained by minimizing the average of the percent distance, dr, between the computed network impedance and measured zl at all frequencies. measured resistance, rl, decreased from 2 to 8 hz and increased from 8 to 32 hz indicating that a single series resistance-iner ...19863789486
ultrastructure of monkey (macaca radiata) spermatozoa: effect of gossypol in vivo.the present study examines the ultrastructure of ejaculated spermatoza from bonnet monkey, macaca radiata under normal conditions, with gossypol treatment and during recovery from such treatment. monkeys were fed orally with gossypol acetic acid (gaa) for 3 months (4 mg/monkey/5 days a week). semen samples collected by electro-ejaculation, and the spermatozoa were examined using both light and electron microscopy. the degree of motility was also noted by kalla et al. ejaculated spermatoza were i ...19863798611
behavior and physiology in young bonnet monkeys.we studied behavioral development in 12 mother-reared social-group-living bonnet macaque (m. radiata monkey infants during the first four months of life. physiological data was subsequently recorded from a subset of six using implantable biotelemetry. we compared these data to similar data previously collected in the same manner from similar age social group living pigtail macaque (m. nemestrina) infants. bonnet infants were more active and apart from mother more throughout development. while in ...19863803725
structure of acidic oligosaccharides isolated from pronase-treated glycoprotein of bonnet-monkey (macaca radiata) cervical mucus.the major glycoprotein component of cervical mucus of bonnet monkey was treated with pronase, and the enzyme-resistant glycoprotein purified by gel filtration on sepharose 4b followed by deae-cellulose chromatography. alkaline-borohydride cleavage of the carbohydrate chains gave a mixture of neutral and acidic oligosaccharides. seven acidic oligosaccharides were characterized by chemical and enzymic procedures; their proposed structures are: alpha neuac(2----3)-[beta galnac(1----4)]beta gal(1--- ...19873829043
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