| kinetic studies and effects of anions on creatine phosphokinase from skeletal muscle of rhesus monkey (macaca mulatta). | a purification procedure for creatine kinase (ec 2.7.3.2) from muscle of the monke35--170 muequiv h+/mg protein per min at 30 degrees c and a yield of approx. 0.5 g/kg muscle. assuming equilibrium kinetics, synergistic binding of substrates at one catalytic site is found for both the forward and back reactions. kinetic constants for the binding of each substrate to the free enzyme and the enzyme-second substrate complex are determined and are compared with those for the enzyme from other species ... | 1975 | 77 |
| the cholinergic system and nociception in the primate: interactions with morphine. | in experiment 1 the shock titration task was used to evaluate the antinoceptive properties of 5 different classes of cholinergic compounds in the rhesus monkey. only scopolamine and high doses of physostigmine were effective in elevating the shock threshold. the apparent antinociceptive effect of physostigmine, however, was difficult to separate from its nonspecific behavioral depressant effect and was probably not related to an increase in cholinergic tone. experiment 2 examined the interaction ... | 1975 | 708 |
| the effect of a simulated subarachnoid hemorrhage on cerebral blood flow in the monkey. | the hydrogen clearance method was used to measure local and total cerebral blood flow (cbf) in the rhesus monkey before and for five hours after a simulated subarachnoid hemorrhage (sah). cbf remained stable after sah unless sah was associated with a fall in cerebral perfusion pressure. in addition, cerebrovascular resistance did not increase after sah. these results suggest that vasoactive agents in fresh whole blood, and the arterial spasm they produce when added to cerebrospinal fluid (csf), ... | 1975 | 820 |
| fluroxene toxicity induced by phenobarbital. | because of reports of fluroxene toxicity in man, the effect of phenobarbital treatment on the toxicity and metabolism of fluroxene was studied in 9 rhesus monkeys. six monkeys that were exposed to a mean calculated alveolar fluroxene concentration of 5.8% for 4-hr periods up to a total of 16 hr showed no evidence of toxicity. two animals were sacrificed after a single 4-hr exposure to obtain control measures of fluroxene metabolites in tissues. four monkeys that had previously survived received ... | 1975 | 1168 |
| absorption and disposition of 2-4-(2,2-dichlorocyclopropyl)phenoxy-2-methylpropanoic acid, win 35,833, in rats, monkeys, and men. | 2-4-(2,2-dichlorocyclopropyl)phenoxy-2-methylpropanoic acid, win 35,833, was readily absorbed after oral administration; in rats, rhesus monkeys, and human volunteers, peak concentrations of drug in plasma were attained within 2 hr of medication. the time-concentration curve of administered drug was biphasic in monkeys and men, while in rats the kinetics of a one-compartment model were observed. distribution studies of 14c-labeled drug in the rat showed that most of the radioactivity was excrete ... | 1975 | 1228 |
| studies on fazadinium bromide (ah 8165): a new non-depolarizing neuromuscular blocking agent. | intravenous dose-response relationships were used to correlate neuromuscular paralysis with the effects of fazadinium (ah 8165) on autonomic mechanisms in anaesthetized cats and rhesus monkeys and with cardiovascular effects in man. in cats and monkeys neuromuscular paralysis of the twitch responses of the gastrocnemius muscle by fazadinium was accompanied by impairment of the vagally induced bradycardia, but cardiovascular disturbances were small. blockade of sympathetic mechanisms and hypotens ... | 1976 | 2378 |
| neurotransmitter regulation of growth hormone and acth in the rhesus monkey: effects of biogenic amines. | in an attempt to clarify the role of central neurotransmitters in gh and acth regulation, chair-adapted unanesthetized adult male rhesus monkeys and chronic indwelling intratrial cannulae were given 30 min infusions of various agonists known to affect central amines, and plasma samples were withdrawn for gh and cortisol determinations. infusion of acid-saline vehicle alone had no significant effect on plasma gh or cortisol (p less than 0.05). l-dihydroxyphenylalanine (l-dopa) (4.5 and 45 mg/kg), ... | 1976 | 2458 |
| sweating responses in the rhesus monkey (macaca mulatta). | | 1976 | 3316 |
| monooxygenase-catalyzed aldrin epoxidation and dihydroisodrin hydroxylation in monkey liver needle-biopsy specimens. assay and properties. | aldrin epoxidation and dihydroisodrin (1,8,9,10,11,11-hexachloro-2,3-7,6-endo-2,1-7,8-endo-tetracyclo 6.2.1.1(3), (6).0(2), (7)dodec-9-ene (dhi) hydroxylation have been studied in 0.2-ml liver monooxygenase preparations. liver biopsy specimens of rhesus (macaca mulatta) and bonnet (m. radiata) monkeys obtained with a 1.9-mm menghini needle were the primary enzyme sources. dieldrin and monohydroxydihydroisodrin (dhi-oh) were the only metabolites detected by electron-capture glc analysis of hexane ... | 1976 | 3398 |
| self-administration of psychomotor stimulant drugs: the effects of unlimited access. | rhesus monkeys surgically prepared with intravenous catheters were given 23 hr daily access to injection of either cocaine, d-amphetamine, 1-amphetamine, d-methamphetamine or diethylpropion on a fixed ratio 1 schedule of reinforcement for a maximum of 30 days. responding was maintained by all these drugs but showed both day-to-day and hour-to-hour variability. the two animals self-administering 0.2 mg/kg/infusion cocaine died in less than 5 days. all 6 animals given access to 0.05 mg/kg/infusion ... | 1976 | 4818 |
| the effect of antihistamines on experimental posttraumatic edema of the spinal cord. | the present experiments were designed to test the effect of antihistamines on the formation of post-traumatic edema of the spinal cord. ten rhesus monkeys received 600 gm cm injuries to the t10 level of the spinal cord. five animals received antihistamine treatment and five animals acted as untreated controls. posttraumatic edema was estimated using radio-active tagged serum albumin. a significant increase in radioactivity of the injured segment was demonstrated in both groups when compared to n ... | 1976 | 4901 |
| defective lipid disposal mechanisms during bacterial infection in rhesus monkeys. | mechanisms producing hypertriglyceridemia during bacterial sepsis have not been well defined. in this study lipid disposal mechanisms were assessed in 76 infected and 19 control male rhesus monkeys by the ability to dispose of triglycerides after: (1) oral lipid loading; (2) intravenous lipid loading; and (3) by lipolytic enzyme activity tests as measured by postheparin lipolytic activity (phla). studies were performed both before and 48 hr after intravenous inoculation with either salmonella ty ... | 1976 | 5648 |
| the projections to the superior temporal sulcus from areas 17 and 18 in the rhesus monkey. | | 1976 | 5733 |
| a comprehensive study of in vitro drug metabolism in several laboratory species. | a shortage of rhesus monkeys for use in drug toxicity studies has made it necessary to search for a potential replacement species in the event that one should be needed in the near future. to this end, 14 parameters of drug metabolism in hepatic microsomal and soluble fractions were examined in preparations from adult male and female rhesus monkeys, squirrel monkeys, hanford miniature pigs, common tree shrews, and sprague-dawley rats. model substrates were utilized and comparisons were made on a ... | 1976 | 6223 |
| mirex kinetics in the rhesus monkey. i. disposition and excretion. | three female rhesus monkeys were given 14c-mirex (5.23 mci/mmol) iv (two animals) or po (one animal) in a dose of about 1 mg/kg for the purpose of determining the distribution and excretion of this polycyclic perchlorinated insecticide. blood, plasma, urine, feces, and tissue samples were analyzed for 14c content. monkeys were autopsied 23, 106, and 388 days after receiving 14c-mirex. following iv administration, plasma 14c showed a rapid decrease over the first few hours from the initial high l ... | 1976 | 6234 |
| mirex kinetics in the rhesus monkey. ii. pharmacokinetic model. | 14c-mirex was given iv and po to female rhesus monkeys (macaca mulatta) and radioactivity was measured in plasma, urine, and feces at intervals after dosing and in tissues when animals were killed. graphical analysis of plots of the logarithm of plasma concentration vs. time was used to provide estimates of the values of the first-order rate constants required by the proposed pharmacokinetic models. a basic-language program, fitkin, was used to obtain numerical solutions to the differential equa ... | 1976 | 6235 |
| metabolic deacetylation: in vitro and in vivo studies in man, rat, dog and rhesus monkey with isomeric tetrahydroisoquinolyl derivatives of 3,4-dimethylbenzyl acetate. | the pharmacological activities of a racemic mixture of tetrahydroisoquinolyl derivatives of 3,4-dimethylbenzyl acetate, (+/-) ro 03-4661 and the corresponding resolved isomers (+) ro 03-4661 and (--) ro 03-4661 have been studied in rat and rhesus monkey. the racemate and the (--) isomer showed narcotic analgesic activity by the oral route in both species. drug metabolism studies indicated that the activity was probably due to metabolic deacetylation to the corresponding carbinol ro 03-4632. deac ... | 1976 | 8060 |
| lung lecithin biosynthesis in the nonhuman primate fetus: determination of the primary pathway in vivo. | the two pathways for de novo lecithin (phosphatidylcholine) biosynthesis, choline incorporation (1) and phosphatidylethanolamine methylation (ii), were examined simultaneously in lung and other tissues of rhesus monkey fetuses. cannulation of interplacental fetal vessels permitted studies on the intrauterine fetus without disruption of fetal-placental-maternal-amniotic fluid anatomic integrity. in contrast to observations with indirect techniques in the same species, direct measurement of the in ... | 1976 | 8165 |
| physiological disposition and metabolic fate of a new antiarrhythmic agent, alpha, alpha-dimethyl-4-(alpha, alpha, beta, beta-tetrafluorophenethyl) benzylamine in the rat, dog, monkey, baboon, and man. | the physiological disposition of a new orally active antiarrhythmic drug, alpha, alpha-dimethyl-4-(alpha, alpha, beta, beta-tetrafluorophenethyl)benzylamine (mk-251) was investigated in the rat, dog, rhesus monkey, baboon, and man. mk-251 was extensively absorbed after oral administration in all species. fecal excretion was the major route of tracer elimination in the rat (70%) and dog (80%), whereas the monkey, baboon, and man excreted the majority of the dose via the urine (40-80%). mk-251 and ... | 1976 | 8295 |
| circulating tissue antigens. iii. identification and characterization of antigens of limited and of wide body is distribution in human gall bladder bile. presence in serum of patients with acute hepatitis. | three antigens shared by bile and tissues (bt-1, bt-2 and bt-3) and one shared by bile and saliva (ba) were identified in human gallbladder bile by immunodiffusion. the former were detected in all bile specimens examined, whereas the latter was detected only in half. bt-1 was limited in distribution to kidney, urine and bile; whereas bt-2 and bt-3 were widely distributed mainly in liver, lung and bile. the antigens were not present in biles of other mammals tested, with the exception of ba which ... | 1976 | 9219 |
| experimental infection of macaca mulatta monkeys with lednice (yaba 1) virus. | macaca mulatta monkeys were inoculated with lednice (yaba 1) virus strain 6118. the animals developed no clinical signs and the body temperature and values of complete haematological examination remained within normal limits. in spite of positive immunofluorescence in regional lymph nodes, no virus could be recovered from them by passages in mice. viraemia was not demonstrated. the antibody response was directly proportional to the amount of virus inoculated, i.e. it was significant after a high ... | 1976 | 9803 |
| respiratory syncytial virus-specific rna synthesis in primary monkey kidney cell cultures. | primary rhesus monkey kidney (mk) cell cultures were inoculated with respiratory syncytial virus and treated or untreated with actinomycin d before pulse labeling with uridine-5-3h. the virus-specific rna synthesis was noted at its peak in the nucleoplasm and possibly less so in the cytoplasm of infected cells. at 48 and 72 hours post-inoculation (p.i.), small fractions of available cells were synthesising virus-specific rna with labeling index of 15% and 18% respectively. by 48 hours p.i. syncy ... | 1976 | 9807 |
| autoregulation of cerebral blood flow and its relation to cerebrospinal fluid ph. | internal carotid artery blood flow (ifbf) was determined in each of nine macaca mulatta by means of a flow transducer implanted around an internal carotid artery. the monkeys were lightly anesthetized, intubated, and paralyzed. normoxia and normocarbia were maintained stable throughout the experiment. icbf was monitored while mean arterial blood pressure (mabp) was lowered by withdrawal of blood. mabp was kept within the known limits of autoregulation in order not to compromise cbf. cerebrospina ... | 1976 | 9834 |
| plasma concentrations in the monkey (macaca mulatta) of six related benzodiazepines after intraperitoneal injection proceedings. | | 1976 | 10030 |
| histamine-induced hypotension modified by h1 and h2 antagonists in the monkey (macaca mulatta). | blocking h2 receptors with burimamide in the dose used (20 mg/kg) approximately doubles the amount of histamine needed to produce the same effect as seen when h1 antagonists (chlorpheniramine or mepyramine) are used alone. the kz ratios for chlorpheniramine-chlorpheniramine plus burimamide are 117-204 and for mepyramine-mepyramine phus burimamide are 200-478. h1 and h2 receptors, in the monkey, when stimulated, both cause cardiovascular responses in the same direction. | 1976 | 11118 |
| species differences in the metabolism and disposition of spironolactone. | the absorption, excretion and metabolism of 22-14cspironolactone was compared in charles river rats, beagle dogs and rhesus monkeys. the drug was administered at the fixed dose of 5 mg/kg po and iv. from the po/iv ratios of the areas under the plasma radioactivity-time curves, the gastrointestinal absorption of the drug was estimated to be 82% in the rat, 62% in the dog, and 103% in the monkey. the absolute bioavailability of a pharmacologically active metabolite, canrenone, was 57% in the dog a ... | 1976 | 11976 |
| combined anatomical and electrophysiological studies on the boundary between the second and third visual areas of rhesus monkey cortex. | | 1976 | 12516 |
| effects of estradiol-17beta on the induction of gonadotropin release by electrical stimulation of the hypothalamus in rhesus monkeys. | serum lh and fsh were measured at 60, 30, and 0 min before, at 5, 15, and 30 min during, and at 10, 45, and 90 min after bilateral electrical stimulation (es) of various hypothalamic regions in 12 unanesthetized ovariectomized rhesus monkeys. es of the arcuate-ventromedial nuclei (medial basal hypothalamus; mbh) induced a prompt increase in serum lh that persisted throughout stimulation and returned to basal levels within 90 min thereafter. fsh was also released, but the release was slower and l ... | 1977 | 12930 |
| the biosynthesis of dimethyltryptamine in vivo. | the in vivo formation of dimethyltryptamine was studied in rabbits, rats and monkeys. when c14-labelled n-methyltryptamine was administered by intravenous injection to rabbits, c14-dimethyltryptamine was found in lung, the principle site of the methyltransferase that biosynthesizes this psychotogen. unequivocal evidence for c14-dimethyltryptamine formation in rat tissues was not obtained. when rabbits were given non-radioactive n-methyltryptamine intravenously, dimethyltryptamine appeared in car ... | 1977 | 14361 |
| gastric emptying and secretion in the rhesus monkey. | the volume and composition of the gastric contents as well as the rates of gastric emptying and secretion were determined simultaneously in conscious chair-adapted monkeys. these determinations were made during fasting and after a liquid meal, thereby allowing studies of the physiologic variables which regulate gastric emptying and gastric secretion. administration of a water meal is followed by a complex pattern of changes in rates of secretion as well as the fractional rate of emptying. during ... | 1977 | 14505 |
| simultaneous anatomical demonstration of the representation of the vertical and horizontal meridians in areas v2 and v3 of rhesus monkey visual cortex. | | 1977 | 15268 |
| mother-infant separation and the nature of inter-individual relationships: experiments with rhesus monkeys. | | 1977 | 15272 |
| a comparative study of the disposition of quinalbarbitone, heptabarbitone and methaqualone in the rhesus monkey (macaca mulatta) and the beagle dog (canis familiaris). | | 1977 | 15775 |
| bone marrow transplantation. | improvements in the results of bone marrow transplantation for the treatment of scid may be expected by employing purified stem-cell concentrates for patients who do not have a compatible sibling available. refinements in the purification technique and its monitoring are required, however. for the same category of patients it seems worthwhile to continue attempts at restoration with liver cells from fetuses less than 12 weeks of age. in addition, full protection against infections should be prov ... | 1977 | 17188 |
| colour coding in the superior temporal sulcus of rhesus monkey visual cortex. | | 1977 | 17866 |
| variation in age at puberty in monkeys. | 5 female and 3 male patas monkeys and 6 female and 3 male talapoin monkeys matured in a captive breeding colony. age at puberty is given, and some variation discussed. the talapoin, a very small monkey, becomes adult at 4 1/2 years for females, 1 or 2 years later for males. the patas, a rather large monkey, becomes adult at 2 1/2 years, for females, and 1 or 2 years later for males. both these ages for puberty differ from data for the rhesus monkey which has been accepted as generalizable to all ... | 1977 | 18386 |
| testosterone production and metabolism in laboratory-maintained male rhesus monkeys. | plasma production rates (pr), metabolic clearance rates (mcr) and plasma levels of testosterone were determined in 10 male, laboratory-maintained rhesus monkeys on two occasions out-of-season (april and august) and once in-season (october). plasma testosterone levels in october were higher than those in april and august. the plasma pr was unchanged in august, but markedly increased in october, as compared to april. the mcr showed a parallel increase betueen august and october. thus changes in te ... | 1977 | 18415 |
| epizootiology, transmission and approach to prevention of fatal simian haemorrhagic fever in rhesus monkeys. | | 1977 | 18679 |
| normal and abnormal middle ear ventilation. | studies in infants and children have suggested a functional rather than mechanical obstruction of the eustachian tube as a predisposing factor in middle ear effusions (mee). to simulate this condition in the laboratory, an animal model was prepared using juvenile rhesus monkeys. the tensor veli palatini muscle was transected or expunged posterior to the hamulus of the medial pterygoid lamina. transection of the muscle resulted in negative middle ear pressure without effusion, whereas when the mu ... | 1977 | 18977 |
| the metabolism of p-methoxyamphetamine in dog and monkey. o-demethylation as a major route. | p-hydroxyamphetamine (pha) and p-hydroxybenzoic acid (phba) have been isolated by gas-liquid chromatography (gc) as urinary metabolites of p-methoxyamphetamine (pma) in dogs and rhesus monkeys. the amounts of pma excreted unchanged in the total 24-hr urine samples in dogs and monkeys were 26% and 3%, respectively, of the total administered doses. the amounts of the pharmacologically active metabolite pha excreted in 24-hr urine samples were 13% in the dog and 44% in the monkey. in the dog, 72% o ... | 1977 | 19212 |
| hydrogen ion and carbon dioxide content of the oviductal fluid of the rhesus monkey (macaca mulatta). | the ph in the oviduct lumen of adult female rhesus monkey (macaca mulatta) during the menstrual cycle was measured by means of miniaturized ph electrodes. two types were used: one was a flexible electrode 1.4 mm in diameter; the other was a rigid electrode 0.8 mm in diameter. the same results were obtained with both types. for pco2 measurements, the ph electrodes was converted to a severinghaus tyep electrode covered with a teflon membrane. during the follicular phase, the ph remains constant in ... | 1977 | 19307 |
| immune responses during measles infection in immunosuppressed rhesus monkeys. | rhesus monkeys immunosuppressed with horse anti-human thymocyte gamma-globulin (atg) were infected with measles and simultaneously inoculated with sheep erythrocytes (srbc), a thymus-dependent antigen, and with pneumococcal polysaccaride type iii (sss-iii), a thymus-independent antigen. atg treatment alone suppressed srbc antibody production, had no effect on sss-iii antibody production, and effectively eliminated circulating t cells compared to nonsuppressed monkeys. atg treatment of measles-in ... | 1977 | 19536 |
| prenatal development of the visual system in rhesus monkey. | | 1977 | 19781 |
| daily changes in the blood of conscious pigs with catheters in foetal and uterine vessels during late gestation. | 1. catheters were inserted into the foetal carotid artery and maternal middle uterine artery and vein in twenty foetuses from fifteen sows, 91-105 days pregnant. blood samples were collected from foetal and maternal circulations for periods of 7-21 days after surgery.2. blood gas tensions, ph, packed cell volume (pcv) and the levels of glucose, fructose and lactic acid in conscious pigs were followed in foetal and maternal bloods during late pregnancy.3. foetal blood gas tensions, ph, pcv, lacti ... | 1977 | 20500 |
| rearing conditions which support or inhibit later sexual potential of laboratory-born rhesus monkeys: hypothesis and diagnostic behaviors. | | 1977 | 20534 |
| comparison of interferon-inducing activities and antiviral effects of tobacco mosaic virus, tilorone and sodium nucleinate. | endogenous interferon was produced in animals in response to the administration of tobacco mosaic virus (tmv), tilorone and sodium nucleinate. the relationship between interferon production and the kind of inducer and the route of its administration was studied. tmv was completely innocuous for macaca rhesus monkeys and mice and caused no untoward effects in humans upon peroral administration. tmv, tilorone and sodium nucleinate given per os exerted a marked protective effect in mice against tic ... | 1977 | 20769 |
| methyl alcohol poisoning. ii. development of a model for ocular toxicity in methyl alcohol poisoning using the rhesus monkey. | rhesus monkeys were intoxicated with methyl alcohol, using an initial dose of 2 gm/kg and subsequent doses were administered in order to maintain an attenuated and prolonged state of intoxication. arterial blood samples were drawn for methyl alcohol, formate, po2, pco2, and ph, which were monitored periodically throughout the course of the experiment. with the use of these procedures monkeys developed metabolic acidosis with the accumulation of formic acid in the blood and a corresponding decrea ... | 1977 | 20870 |
| proton magnetic resonance studies of histidines in human, rhesus monkey, and bovine carbonic anhydrases. | histidine c-2 proton resonances in rhesus monkey carbonic anhydrase b (carbonate hydro-lyase, ec 4.2.1.1) and bovine carbonic anhydrase were investigated using 270-mhz proton magnetic resonance. the results suggest that there are extensive three-dimensional homologies between the human b and rhesus b enzymes and between the human c and bovine enzymes. resonances from solvent exchangeable protons have been observed in the 11-16 ppm range in the nmr spectra of human carbonic anhydrases b and c and ... | 1977 | 20966 |
| methadone n-oxide in the rhesus monkey. | | 1977 | 21270 |
| effect of multiple-stress procedures on monkey gastroduodenal mucosa, serum gastrin, and hydrogen ion kinetics. | by arranging a series of psychological contingencies (unpredictability, uncontrollability, conflict), coupled with delivery of a physical stimulus (electric shock), we produced gastroduodenal mucosal lesions in 7 of 8 rhesus monkeys. the most severe conflict paradigm most consistently produced lesions across subjects. of the 30 lesions observed by endoscopy, 80% occurred near the anatomic junction of gastric body and antrum, in the antrum, or in the duodenum. lesions varied in severity from disc ... | 1977 | 21564 |
| in vitro biosynthesis of radioactive estradiol-17 beta, 17-glucosiduronate by rhesus monkey liver. | a method for the preparation of radioactive estradiol-17 beta, 17-glucosiduronate by incubating 3h-estradiol with rhesus monkey liver microsomal preparation in the presence of uridine diphosphoglucuronic acid is described. small but significant amounts of the conjugate were also obtained from the 150,00 pellet and cytosol fractions. the addition of nadph to the incubation media increased the yield of radioactive-estradiol-17 beta, 17-glucosiduronate perhaps by preserving the integrity of the c-1 ... | 1977 | 22146 |
| characterization of the adrenergic activity of carbuterol (sk&f 40383-a). | carbuterol is a beta-adrenergic bronchodilator with selectivity for bronchial smooth muscle relative to cardiac and vascular tissues of several species including man. the present studies were undertaken to further characterize its adrenergic profile. in vitro studies demonstrated that carbuterol was a direct acting beta-adrenergic agonist, not dependent on endogenous catecholamine release, and was devoid of alpha-adrenergic agonist activity. the activity of the racemate was shown to reside prima ... | 1977 | 22441 |
| disseminated intravascular coagulopathy during experimental pneumococcal sepsis: studies in normal and asplenic rhesus monkeys. | disseminated intravascular coagulation (dic) was induced in both normal and asplenic rhesus monkeys by intravenous challenge with streptococcus pneumoniae. our observations in the infected monkeys have led us to conclude that (1) pneumococcal capsular polysaccharide (pcp), immune complexes and complement may not have primary roles in the initiation of dic; (2) intact pneumococci may be catalysts for the development of dic; (3) the initial event in dic may be activation of hageman factor; and (4) ... | 1977 | 22758 |
| endotoxemia and large intestinal blood flow in subhuman primates. | the hemodynamic effects of escherichia coli endotoxin (ld80) were measured in the large intestine of anesthetized rhesus monkeys to determine whether this organ contributes to the pathogenesis of experimental shock. inferior mesenteric arterial blood flow (imf) was measured with an electromagnetic flowmeter. pressures within the aorta (ap) and portal vein (pp) were recorded. distribution of colon blood flow was measured with radioactive microspheres: ce, sr, and cr were injected into the left he ... | 1977 | 23223 |
| response of the epididymis, ductus deferens & accessory glands of the castrated prepubertal rhesus monkey to exogenous administration of testosterone or 5alpha-dihydrotestosterone. | the response of the epididymis, ductus deferens, and accessory glands of the castrated prepubertal rhesus monkey to exogenous administration of testosterone or 5alpha-dihydrotestosterone (dht) was investigated. 200 or 800 mcg of either steroid/day were administered for 60 days beginning on the day after castration. castration caused a marked regression of the weight of and secretory function of the reproductive organs; testosterone/dht stimulated their growth and secretory activity which were ... | 1977 | 23997 |
| functional maturation of the epididymis in rabbit and rhesus monkey. | the changes in the weight, histology and biochemical composition of the epididymis (caput, corpus and cauda segments) in prepuberal rabbit and rhesus monkey in response to testosterone treatment were investigated. the increase in the weight of the organ was accompanied by increased levels of rna and dna. androgen therapy caused an increase in the concentration of sialic acid, phospholipids and glycerylphosphorylcholine and activities of alkaline phosphatase, acid phosphatase and hyaluronidase. t ... | 1977 | 24535 |
| biotransformation products of 3,4,4'-trichlorocarbanilide in rat, monkey, and man. | 3,4,4'-trichlorocarbanilide (tcc), uniformly labeled with 14c in the monochloro ring, was administered to rats, rhesus monkeys, and humans. radioactive materials in the plasma and urine of all three species and in the bile of rats and monkeys were separated by high performance liquid chromatography. the chromatography showed great similarity between the monkey and the human. principal metabolites common to all species were the sulfate and glucuronide conjugates of 2'-, 3'-, and 6-hydroxy-tcc. th ... | 1978 | 26533 |
| the physiological disposition of (2-cyclopentyl-6,7-dichloro-2-methyl-1-oxo-5-indanyloxy)acetic acid in the rat, dog, rhesus monkey, and baboon. | | 1978 | 26553 |
| androgen concentration and partial characterization of 5alpha reductase in the epididymis of the rhesus monkey. | the 5alpha reductase activity ofthe monkey epididymis was studied. the enzyme was found in particulate subcellular fractions, its distribution closely resembling that of the microsomal marker enzyme nadph: cytochrome c reductase, suggesting an association of 5alpha reductase with membranes of the endoplasmic reticulum. maximal enzyme activity was found at ph 5.4 and at 32--37 c. the crude nuclear preparation had a km: 0.315 x 10(-6)m and vmax: 168 pmoles/mg protein/h. the microsomal enzyme had a ... | 1978 | 26992 |
| the influence of maternal psychological stress on the fetus. | the effects of maternal agitation, induced by exposure to bright light, upon fetal well-being were studied in pregnant rhesus monkeys at 139 to 148 days of gestation. fetuses were classified as "healthy" or "asphyxiated" according to their initial acid-base state. following variable periods of maternal excitement, a decrease in heart rate and arterial oxygenation was seen in all fetuses. recovery occurred more rapidly in the healthy group, after maternal sedation was achieved, either by removing ... | 1978 | 27097 |
| effectiveness of pyridostigmine in reversing neuromuscular blockade produced by soman. | the effects of pyridostigmine pretreatment on the neuromuscular blockade produced by soman in anaesthetized, atropinized animals have been studied on the soleus and anterior tibialis muscle (rhesus monkeys, cats and rabbits) and the gastrocnemius muscle (guinea-pigs and rats). pyridostigmine pretreatment produced a complete recovery of neuromuscular function following blockade by soman; the rate of recovery was similar in all the species, suggesting a common mechanism of action. in the absence o ... | 1978 | 27607 |
| glutathione depletion following inhalation anesthesia. | glutathione depletion following inhalation of halogenated anesthetics was investigated as a possible mechanism of toxic reactions associated with anesthesia. concentrations of reduced glutathione were measured in the blood, liver, lung and kidney of the mouse after anesthesia with enflurane, fluroxene, halothane, isoflurane, methoxyflurane, or trichloroethylene. the anesthetic had no effect on glutathione concentrations in tissues except when fluroxene was used. after two hours of fluroxene anes ... | 1978 | 28682 |
| platelet monoamine oxidase activity in 116 normal rhesus monkeys: relations between enzyme activity and age, sex and genetic factors. | | 1978 | 28881 |
| disposition of 4,5-diphenyl-2-oxazolepropionic acid (oxaprozin) in beagle dogs and rhesus monkeys. | following intragastric doses of 14c-oxaprozin to beagle dogs and rhesus monkeys, oxaprozin was rapidly absorbed and was essentially the only drug-related substance in the plasma for at least 24 hr. recovery of radioactivity in the excreta was 87% in both species, with the fecal route accounting for almost all of the excretion by the dog, and the urinary route predominating in the monkey. the drug was slowly eliminated by both species. the concentrations in tissues of monkeys were generally less ... | 1978 | 28928 |
| the effects of isoproterenol on fetal oxygenation. | infusion of isoproterenol (1 microgram/kg/min, i.v.) into the anesthetized pregnant rhesus monkey near term consistently reduced fetal oxygenation, despite diminishing myometrial activity. the decline in po2 of fetal arterial blood (mean = 4.3 +/- 2.3 mmhg s.d.) was accompanied by an increase in pco2 tension (mean = 4.6 +/- 2.7 mmhg) and a decline in ph (mean = 0.04 +/- 0.02 s.d.). there was an increase in heart rate and a widening of pulse pressure in the mother and also in the adequately oxyge ... | 1978 | 29437 |
| cardiac systolic time intervals in fetal monkeys: pre-ejection period. | the systolic time intervals of the fetal cardiac cycle were studied by means of simultaneous recordings of electrocardiogram (ecg) and ultrasound doppler cardiogram (dcg) in chronic preparations of fetal rhesus monkeys. recordings were made under physiologic conditions as well as during various experimental stresses. the pre-ejection period (pep) showed no significant relationship with heart rate in the unstressed fetuses, but the acceleration of heart rate induced by epinephrine was accompanied ... | 1978 | 30282 |
| species differences in the disposition and metabolism of 6,11-dihydro-11-oxodibenz[be]oxepin-2-acetic acid (isoxepac) in rat, rabbit, dog, rhesus monkey, and man. | the disposition and metabolism of 6,11-dihydro-11-oxodibenz[be]oxepin-2-acetic acid (isoxepac), a new nonsteroidal anti-inflammatory agent, has been studied in rat, rabbit, dog, rhesus monkey, and man. animals were given single oral or parenteral doses of 5 or 50 mg/kg; man received approximately 3 mg/kg orally. fecal excretion of radioactivity occurred in the rat (26--37%) and dog (33--49%), whereas in the other species elimination was mainly urinary (less than 83%). biliary excretion accounted ... | 1978 | 30600 |
| improved ventilation of prematurely delivered primates following tracheal deposition of surfactant. | twelve rhesus monkeys were delivered prematurely at 129, 130, or 131 days. the first breath was inhibited while tracheotomy was performed and a catheter introduced into the umbilical artery. into the tracheal tubes of six of the newborn monkeys was instilled 0.20 to 0.27 ml. of a natural surfactant (sa) suspension, obtained from lung wash of adult rabbits. nothing was given to six control monkeys. breathing was then supported with a ventilator. although its settings were adjusted in attempts to ... | 1978 | 31091 |
| bile duct cysts secondary to liver infarcts: report of a case and experimental production by small vessel hepatic artery occlusion. | hepatic bile duct cysts were demonstrated on an abdominal ct scan and confirmed at autopsy in a patient with polyarteritis nodosa. the cysts developed in close proximity to hepatic artery aneurysms and occlusions visualized at hepatic arteriography and confirmed postmortem. the development of similar bile duct cysts following hepatic artery occlusion was demonstrated in 13 rhesus monkeys. | 1979 | 31659 |
| etonitazene as a reinforcer: oral intake of etonitazene by rhesus monkeys. | drinking of etonitazene hci was studied in three rhesus monkeys during daily 3-h sessions. as the drug concentration was increased, the number of liquid deliveries decreased, and etonitazene intake (microgram/kg body weight) increased. as fixed-ratio (fr) requirements were increased, rate of responding increased, and liquid deliveries slightly decreased. when water was substituted for the drug, there was a large increase in responding for several sessions, followed by a slow decline to low rates ... | 1978 | 32572 |
| evaluation of succinimidoethyl and pivaloyloxyethyl esters as progenitors of methyldopa in man, rhesus monkey, dog, and rat. | the succinimidoethyl (sm) and pivaloyloxyethyl (p) esters of methyldopa were evaluated as progenitors of the latter. experiments in spontaneously hypertensive (sh) rats and humans demonstrated that a radioactive dose of progenitor was well absorbed. the metabolism of these progenitors appeared to be comparable in the sh rat; the urinary excretion of [3h]methyldopa was similar after oral administration of [3h]sm or [3h]p. in humans the levels of [3h]methyldopa were higher in the urine following a ... | 1978 | 33026 |
| physiological disposition and metabolism of cyclobenzaprine in the rat, dog, rhesus monkey, and man. | the absorption, distribution, excretion, and metabolism of 3-(5 h-dibenzo[a,d]cyclohepten-5-ylidene)-n,n-dimethyl-1-propanamine (cyclobenzaprine) were investigated in the rat, dog, rhesus monkey, and man. the drug was well absorbed in all species after oral administration. the rat eliminated the drug primarily in the feces, but urinary excretion was predominant in the dog, monkey, and man. the drug was rapidly and widely distributed into rat tissues, highest concentrations being found in the sma ... | 1978 | 33029 |
| plasmodium knowlesi in the marmoset (callithrix jacchus). | common marmosets were shown to be susceptible to plasmodium knowlesi malaria. the morphology of the parasite was indistinguishable from the observed in the natural host (macaca fascicularis) and the common laboratory model (macaca mulatta). a differential susceptibility to p. knowlesi was observed in the 8 marmosets studied. multiplication rates of parasites were variable over 24 h periods. five animals died of a fulminating infection within 12--17 days after challenge. three animals recovered s ... | 1979 | 33359 |
| the metabolic disposition of norgestrel in female rhesus monkeys. | following single intragastric doses of d- and dl-[24c]norgestrel (ng), rhesus monkeys excreted 29.5 +/- 2.0 (se) and 52.6 +/- 5.4% of the administered radioactivity in urine. fecal excretion accounted for 57.1 +/- 4.0 and 37.2 +/- 4.4%, respectively. urinary radioactivity was separated into neutral, acidic, and conjugated fractions. the neutral and conjugated fractions contained ng; 2 alpha, 16 alpha- and 16 beta-hydroxy-ng; 3 alpha,5 beta-tetrahydro-ng and 16 beta-hydroxy-3 alpha,5 beta-tetrahy ... | 1979 | 35318 |
| airway sensitivity to slow-reacting substance of anaphylaxis, histamine, and antigen in ascaris sensitive monkeys. | the effects of ascaris suum antigen, histamine, and slow-reacting substance of anaphylaxis (srs-a) on the respiratory system were compared in 3 anesthetized rhesus monkeys. the agents were administered by instillation into the trachea, and the animals were studied in a volume displacement body plethysmograph. two of the animals showed skin and bronchial sensitivity to ascaris suum antigen and responded to it with increased pulmonary resistance and decreased dynamic compliance. a similar response ... | 1979 | 36017 |
| four stimulants of the central nervous system: effects on short-term memory in young versus aged monkeys. | aged rhesus monkeys and young control monkeys were tested in a delayed-response procedure to assess the effects of central-nervous-system (cns) stimulants on short-term memory (stm). previous research had established that the aged monkeys showed specific impairments of stm in this procedure. four different cns stimulants (methylphenidate, magnesium pemoline, a pentylenetetrazole/niacin mixture, and caffeine) were chosen for evaluation on the basis of their relevancy to current geriatric-psychoph ... | 1979 | 36423 |
| a summary of the results of a drug self-administration study using substitution procedures in rhesus monkeys. | | 1978 | 36945 |
| regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus monkey: concentrations and in vivo synthesis rates. | endogenous monoamine concentrations and turnover rates vary markedly in different regions of neocortex as well as in various subcortical structures of young adult rhesus monkeys. monoamine levels and synthesis rates in amygdala, hippocampus, neostriatum, thalamus and brain stem are generally similar to comparable measures previously reported in a variety of species. however, extending and confirming the results of an earlier study, cortical monoamines exhibit topographically specific patterns of ... | 1979 | 36962 |
| subcellular distribution and properties of intestinal histamine-metabolizing enzymes from rats, guinea pigs and rhesus monkeys. | | 1979 | 37037 |
| the protection of primates against soman poisoning by pretreatment with pyridostigmine. | the effectiveness of pyridostigmine pretreatment against soman poisoning has been determined in rhesus monkeys and marmosets receiving atropine therapy. pretreatment with the maximum sign-free dose (200 microgram kg-1, i.v.) raised the subcutaneous ld50 of soman by a factor of 28 in rhesus monkeys and 15 in marmosets. the protection afforded by a quarter of the sign-free dose of pyridostigmine was not significantly less. these levels of protection are higher than any reported in non-primate spec ... | 1979 | 37298 |
| disposition of flunisolide in the rat, mouse, dog, rhesus monkey, and cynomolgus monkey. | flunisolide (6 alpha-fluoro-11 beta, 16 alpha, 17 alpha, 21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide) administered as a single iv or oral dose to rats, mice, dogs, rhesus monkeys, and cynomolgus monkeys had a plasma t 1/2 of 1-3.5 hr and was eliminated mainly via the bile. after iv administration of 14c-labeled flunisolide, radioactivity was widely distributed into tissues and organs. the apparent volume of distribution of flunisolide in these five species was 3.0-8.0 liters/kg. a ... | 1979 | 38078 |
| the effect of histamine-1 and histamine-2 antagonists on airway responses to histamine in the rhesus monkey. | this study used rhesus monkeys with consistent respiratory responses to aerosolized histamine. two systems of histamine challenge were evolved to study the effects of histamine antagonists on the histamine-induced respiratory response. one system consisted of administering increasing subreactive concentrations of histamine until an airway response (h) occurred. this threshold histamine dose was repeated (h'). the pulmonary function changes occurring with the h' challenge were less intense than t ... | 1979 | 38270 |
| fucntional specialization and binocular interaction in the visual areas of rhesus monkey prestriate cortex. | if is is believed that neural mechanisms mediating stereoscopic vision may be localized in specific areas of the visual cortex, then it becomes necessary to be able to define these areas adequately. this is no easy matter in the rhesus monkey, an animal close to man, where the cytoarchitecturally uniform prestriate cortex is folded into deep sulci with secondary gyri. one way around this awkward problem is to use the callosal connections of the prestriate cortex as the anatomical landmarks. call ... | 1979 | 38453 |
| brain damage and global stereopsis. | when a single object lies in front of or beyond the plane of fixation its retinal image lies on disparate positions in the two eyes. this 'local' retinal disparity is an excellent cue to depth, and retinal disparties of a few seconds of arc are detectable by people and monkeys. however, most visual scenes produce a complex array of contours in each eye and we can detect the disparity in the arrays despite the ambiguous nature of the disparities, i.e. each contour in one eye could be related to a ... | 1979 | 38454 |
| depth sensitivity of binocular cortical neurons of behaving monkeys. | activity of neurons if foveal striate and prestriate cortex of trained rhesus monkeys was recorded with metal microelectrodes. while animals fixated a small spot at a given fixation distance (38 or 57 cm), bright or dark bars moving across a frontoparallel plane were presented at different depths in a range of +/- 10 cm about the fixation distance. almost all cells showed binocular interaction. neurons with balanced ocularity (approximately equal monocular responses) usually facilitated each oth ... | 1979 | 38455 |
| breathing movements before death in the primate fetus (macaca mulatta). | the incidence and character of fetal breathing movements (fbms) were determined by analysis of continuous tracheal pressure recordings in a 48 hour period preceeding fetal death in utero in 7 chronic pregnant monkey preparations (macaca mulatta). all fetuses were judged normal by blood gas tensions, ph, and fetal heart rate within 48 hours of death. in the normal fetus breathing movements were periodic and a circadian distribution in the incidence of fbms was observed. four distinct patterns of ... | 1979 | 38667 |
| [clinical and immunological studies on acquired heat contact urticaria (author's transl)]. | a case of localized urticaria in an otherwise healthy young woman, produced only by direct contact of the skin with heat, is described. the minimal temperature of urtication was 44 degrees c (immersion of the forearm in hot water for 5 min). redness and painful oedema immediately developed without reflex flare. total serum igg, iga, igm, ige, complement factors c3 and c4, and alpha1-antitrypsin were in the normal range, whereas the c1-inhibitor level was slightly decreased. there was no evidence ... | 1979 | 39803 |
| morphological characterisitcs of the pathological process in the central nervous system of monkeys infected with variants of measles virus strain l-16. | the neurovirulence of l-16 vaccine measles virus strains and its 9 clonal variants was investigated in intracerebrally infected macaca mulatta monkeys. two groups of clones were distinguished: one comprised variants that caused destructive changes of neurons in the brain and diffuse proliferative gliosis, and the second variants that caused changes of a transitory character, connected with the traumatic exposure. | 1979 | 42298 |
| international forum update: depot medroxyprogesterone acetate and endometrial carcinoma. | in response to a recent report (fam plann perspect 11: 47, 1979) that two of 12 rhesus monkeys given 50 times the human dose of depot medroxyprogesterone acetate (dmpa), by body weight, for ten years had developed endometrial carcinoma (ca), a retrospective survey of all hospital admissions for proven endometrial ca in two thai provinces where dmpa contraceptive injections have been widely used since 1965 was made. from 1974 through 1978, 16 women were hospitalized with confirmed diagnoses of en ... | 1979 | 42591 |
| comparative bioavailability and pharmacokinetic studies of azathioprine and 6-mercaptopurine in the rhesus monkey. | azathioprine (aza) is cleaved in vivo by glutathione to 6-mercpatopurine (6-mp). 6-mp plasma levels were measured by hplc in four male rhesus monkeys following oral and iv doses of the two drugs. following iv 6-mp administration, 6-mp levels were described by a two-compartment body model; mean terminal half-life; plasma clearance (clp), and volume of distribution (vdss) were 41.6 +/- 12.1 min, 48.4 +/- 15.4 ml/min/kg, and 1.76 +/- 0.64 liters/kg, respectively. 8-hydroxymercpatopurine (8-ohmp) wa ... | 1979 | 43222 |
| determination of the anti-allergenic agent, 2-methoxy-11-oxo-11h-pyrido[2,1-b]quinazoline-8-carboxylic acid, in biological fluids by high-performance liquid chromatography. | a rapid, sensitive, and specific high performance liquid chromatographic (hplc) assay was developed for the determination of 2-methoxy-11-oxo-11h-pyrido-[2,1-b]quinazoline-8-carboxylic acid (i) from biological fluids. the overall recovery from blood and plasma is 69 +/- 10% (s.d.) and 84 +/- 6% (s.d.), respectively, and the sensitivity limit of quantitation is 100 ng/ml by uv absorption and 5 ng/ml by fluorescence detection using a 1 ml specimen. the assay was used in the determination of blood ... | 1979 | 44301 |
| interactions of pharmacological agents which alter biogenic amine metabolism and depression--an analysis of contributing factors within a primate model of depression. | the observation that the biogenic amine depleting agent, reserpine, could induce severe depression in a small proportion of the patients treated with it has proved to be seminal finding in what is now a much larger field of research relating the function brain biogenic amine systems to emotions and behavior. a review of the human reserpine literature suggests, however, that factors other than pharmacologically produced alterations in brain biogenic amine metabolism must have been critical determ ... | 1979 | 45183 |
| azidomorphines: a new family of potent analgesics with low dependence capacity. | 1. structure-activity relationship studies with new semi-synthetic isomorphine derivatives revealed that substitution of an azido group in position 6 (azidomorphines) greatly increases the analgesic potency whereas tolerance and dependence liability tend to decrease. 2. azidomorphine (6-deoxy-6-azidodihydroisomorphine) and 14-hydroxyazidomorphine (6-deoxy-6-azidodihydro-14-hydroxyisomorphine) being in animal tests 40-300 times more potent than morphine, are the most effective analgesics among th ... | 1979 | 45567 |
| intraepithelial lymphocytes in the male reproductive tract of rats and rhesus monkeys. | although lymphocytes are never present in 'normal ' seminiferous epithelium, they are found in the terminal portions of the seminiferous tubles near their junctions with the tubuli recti. intraepithelia lymphocytes are also found in the tubuli recti testis, ductuli efferentes, epididymis and ductus deferens. the ultrastructural morphology of these cells closely resembles that of the intraepithelial lymphocytes in the intestinal mucosa and those obtained from the lymph nodes, spleen blood and tho ... | 1975 | 45940 |
| cortico-striatal evoked potentials in the monkey (macaca mulatta). | a systematic study has been made of topographic organization in the striatum of evoked potentials elicited by stimulation of the cerebral cortex in unanesthetized, comatose monkeys (macaca mulatta). stimulation of the dorsal field of the prefrontal convexity elicited potentials primarily in rostral portions of the caudate, while stimulation of the ventral field of the prefrontal convexity elicited potentials in ventromedial areas of the putamen. stimulation of different points on the precentral ... | 1975 | 45942 |
| slow axonal protein transport and visual function following retinal and optic nerve ischemia. | retinal ganglion cell protein synthesis and slow axonal protein flow have been measured in eight optic nerves from four macacus rhesus monkeys after producing ganglion cell ischemia. comparison of the slow axonal protein flowing into the two optic nerves of the same control animal reveals a variability of up to 27 per cent. following central retinal artery ligation, infarction of the retinal ganglion cells was reflected by a 97 per cent reduction in the radioactively labeled protein within the o ... | 1975 | 46218 |
| serological analysis of human deoxyribonucleic acid polymerases. preparation and properties of antiserum to deoxyribonucleic acid polymerase i from human lymphoid cells. | the preparation and properties of an antiserum to human dna polymerase i (6 to 8 s) are described. care was taken in the purification of the antigen to remove certain other dna polymerases found in human cells. an incubation of antigen and antiserum lasting about 48 hours is necessary to achieve maximal inhibition. about 1 mug of the antipolymerase immunoglobulin g, prepared in rats, neutralizes 60% of the activity present in 54 ng of the enzyme. tritrations varying both antiserum and enzyme dem ... | 1975 | 46229 |
| allergic encephalomyelitis. isolation of an encephalitogenic peptide active in the monkey. | a 17-residue peptide (peptide y) was isolated from the cooh-terminal end of the basic protein of bovine myelin by peptic digestion. this peptide induced experimental allergic encephalomyelitis in the rhesus monkey. treatment of peptide y with cyanogen bromide released three amino acids from the cooh-terminal end and resulted in a tetradecapeptide (peptide m) which was also encephalitogenic in the rhesus monkey. the sequence of peptide m is: phe-lys-leu-gly-gly-arg-asp-ser-arg-ser-gly-ser-pro-met ... | 1975 | 46230 |
| effects of repeated oral doses of demethylchlortetracycline on bones and dentin of young rhesus monkeys. | seven oral doses of demethylchlortetracycline were administered to monkeys that received serial injections of lead acetate to intravitally stain calcification sites. bone growth was greatly inhibited, whereas dentin apposition was spared from the cumulative toxicity of demethylchlortetracycline. cessation of bone growth and its duration could be correlated with serum levels. | 1975 | 46870 |
| hazards from simian herpes viruses: reactivation of skin lesions with virus shedding. | a new simian herpes virus with biological properties similar to herpes simplex and to simian "b" virus has been used as a model system for studying virus latency in dorsal root spinal sensory ganglia. following intradermal injection, virus is present in the skin lesions and corresponding ganglia only, during the acute stage of the disease. by organ-culture techniques, latent virus was rescued from ganglia up to 2 years later. no latent virus was ever found in skin organ cultures of the primar ... | 1975 | 47078 |