| human and monkey prolactin and growth hormone: separation of polymorphic forms by isoelectric focusing. | the feasibility of using isoelectric focusing for the separation of primate pituitary growth hormone from prolactin and for the characterization of polymorphic forms of these hormones was explored. in a ph 3--10 gradient, extracts of both human and cynomolgus monkey pituitaries were each resolved into 4 growth hormone components and at least 3 prolactin components, as shown by radioimmunoassay. in narrower gradients (of 2--3 ph units) greater resolution was achieved; the principal growth hormone ... | 1975 | 227 |
| experimental diarrhea in cynomolgus monkeys by oral administration with clostridium perfringens type a viable cells or enterotoxin. | purified c. perfringens type a enterotoxin fed orally in an amount of 5 mg caused both vomiting and diarrhea in the monkey only when the gastric juice had been neutralized. exposure of enterotoxin to ph 4.0 or below rapidly destroyed the activity. all three monkeys receiving sodium bicarbonate and 2.4 x 10(10) viable cells grown in ds medium developed diarrhea, and only one of them vomited once. the diarrhea lasted for 13, 18 and 19 hr. the symptoms were similar to those reported in human cases ... | 1975 | 525 |
| perinephritis hypertension in monkeys. i. an increase of plasma renin activity associated with increased permeability of retinal vessels and angionecrosis. | the renal parenchyma of 5 crub-eating monkeys (macaca irus) was wrapped by cellophane, and plasma renin activity, blood pressure and vascular permeability of ocular ground were measured in comparison with 5 unoperated control monkeys. the results demonstrated that increases of systolic arterial pressure, plasma renin activity, and permeability of the retinal vessels were found in 4 operated monkeys. there was no such abnormal finding in the unoperated control monkeys. generally there was a rough ... | 1976 | 6807 |
| pneumococcal leptomeningitis in cynomolgus monkeys (macaca fascicularis). | | 1976 | 10668 |
| the structure and function of acid proteases. vii. distribution and some properties of acid proteases in monkey tissues. | 1. the distribution of acid protease activity in various tissues of japanese monkey (macaca fuscata fuscata) was investigated with hemoglobin as a substrate at ph 3.0. the activity per protein weight in crude extracts was highest in spleen and lung, and decreased in the order: spleen, lung greater than kidney, testis greater than brain greater than liver, placenta greater than thyroid gland, muscle. the activity in crude muscle extract was about one-tenth those of spleen and lung. the activity p ... | 1977 | 14947 |
| plasmodium knowlesi in the marmoset (callithrix jacchus). | common marmosets were shown to be susceptible to plasmodium knowlesi malaria. the morphology of the parasite was indistinguishable from the observed in the natural host (macaca fascicularis) and the common laboratory model (macaca mulatta). a differential susceptibility to p. knowlesi was observed in the 8 marmosets studied. multiplication rates of parasites were variable over 24 h periods. five animals died of a fulminating infection within 12--17 days after challenge. three animals recovered s ... | 1979 | 33359 |
| pharmacological studies on cs-430, a new psychotropic agent. | 10-bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6(5h)-one (cs-430) is a new psychotropic drug and has the following properties. the compound showed sleep-inducing effect at both 0.2 and 5 mg/kg (p.o.) in cynomolgus monkeys or at 3 mg/kg (p.o.) in rats. cs-430 showed selective conflict attenuating in rats or anticonvulsant effects in mice. furthermore, cs-430 blocked non-discriminated (sidman) avoidance response without severe impairment of the motor function bu ... | 1978 | 35173 |
| delayed-onset pulmonary insufficiency in primates resuscitated from hemorrhagic shock. | forty-one unanesthetized cynomolgus monkeys were subjected to 2 hours of hemorrhagic hypotension at various mean arterial pressures (map) between 40 and 60 mm hg. resuscitation and maintenance of map were provided by lactated ringer's solution and homologous blood. thirty-eight per cent (57% of those surviving greater than 24 hours) developed a delayed-onset (18 to 24 hours) pulmonary insufficiency in spite of good urinary output, and which did not respond to furosemide. the group in which this ... | 1979 | 36483 |
| disposition of flunisolide in the rat, mouse, dog, rhesus monkey, and cynomolgus monkey. | flunisolide (6 alpha-fluoro-11 beta, 16 alpha, 17 alpha, 21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide) administered as a single iv or oral dose to rats, mice, dogs, rhesus monkeys, and cynomolgus monkeys had a plasma t 1/2 of 1-3.5 hr and was eliminated mainly via the bile. after iv administration of 14c-labeled flunisolide, radioactivity was widely distributed into tissues and organs. the apparent volume of distribution of flunisolide in these five species was 3.0-8.0 liters/kg. a ... | 1979 | 38078 |
| bilateral projections from precentral motor cortex to the putamen and other parts of the basal ganglia. an autoradiographic study in macaca fascicularis. | by tracing radioactively labeled proteins transported by axonal flow, projections from area 4 to the ipsi- and contralateral neostriatum and claustrum were demonstrated in 7 monkeys. a reversed topographic organization was found on both sides for the corticoneostriatal and corticoclaustral projections. the most extensive terminal field could be observed in the putamen. in contrast, very few area 4 efferents seemed to terminate in the caudate nucleus. this suggests differential functions for the ... | 1975 | 50112 |
| antibody response in the parotid fluid and serum of irus monkeys (macaca fascicularis) after local immunization with streptococcus mutans. | the antibody response of macaca fascicularis in parotid saliva and serum to local immunization by two routes with streptococcus mutans was studied and compared over 1 year. antibodies were titrated and classified by indirect immunofluorescent staining using specific antiglobulin conjugates. antiglucosyltransferase activity was assayed by an enzyme inhibition test. animals were immunized first by injecting formalin-killed bacterial cells and cell products subcutaneously into the vicinity of the f ... | 1975 | 50286 |
| orthograde and retrograde axoplasmic transport during acute ocular hypertension in the monkey. | orthograde and retrograde axoplasmic transport have been studied in the optic nerve heads of 37 macaca fascicularis eyes with normal or elevated intraocular pressure (iop) produced by cannulation of the anterior chamber. orthograde transport was labeled by 3h-amino acids injected intravitreally and incorporated into retinal ganglion cell proteins. retrograde transport was studied in the same eyes by injecting horseradish peroxidase (hrp) into one or both optic tracts and dorsal lateral geniculat ... | 1977 | 67096 |
| axoplasmic transport in ocular hypotony and papilledema in the monkey. | orthograde and retrograde axoplasmic transport were studied in optic nerve heads of seven hypotensive macaca fascicularis eyes. orthograde transport was studied by radioautography after intravitreal radioisotope injections. retrograde transport was studied in the same eyes by horseradish peroxidase injection into the dorsal lateral geniculate nuclei or optic tracts. three eyes had developed marked papilledema before injections. orthograde axoplasmic transport was blocked in swollen axons of the ... | 1977 | 70200 |
| light and electron microscopic histochemistry of the serous secretory granules in the salivary glandular cells of the mongolian gerbil (mongolian meridianus) and rhesus monkey (macaca irus). | | 1977 | 71867 |
| surface antigenic characteristics of human glial brain tumor cells. | the surface antigenic characteristics of human glial brain tumor (hgbt) cells were studied by complement-dependent cytotoxic antibody assays and indirect membrane immunofluorescence. eight permanent, well-characterized cell lines derived from human gliomas were used for analysis with antisera raised by hyperimmunization of nonhuman primates (macaca fascicularis) with glioblastoma multiforme tissue or established hgbt cells lines. exhaustive absorption of these antisera to remove predominantly an ... | 1977 | 72598 |
| differential laminar distribution of corticothalamic neurons projecting to the vl and the center median. an hrp study in the cynomolgus monkey. | | 1978 | 80251 |
| projections of the precentral motor cortex and other cortical areas of the frontal lobe to the subthalamic nucleus in the monkey. | corticofugal projections were examined by means of the autoradiographic tracer method in 21 macaca fascicularis. the labeled material was injected into the main body representation areas of the precentral motor cortex and into various regions of brodmann's areas 6, 8 and 9 of the frontal lobe. the ipsilateral subthalamic nucleus receives a moderately strong and somato-topically organized projection from woolsey's precentral motor cortex. this projection is mainly restricted to the lateral moiety ... | 1978 | 83239 |
| location of taste buds in intact taste papillae by a selective staining method. | taste buds were found to stain strongly and selectively in intact papillae with highly acidic dyes such as ponceau s. in intact tongues the taste buds in the fungiform, circumvallate and foliate papillae of the cynomolgus monkey and in the fungiform papillae of the rat as well as the taste discs in the fungiform papillae of the frog could be visualized. this method enables a rapid location and counting of taste buds in taste papillae without preparing histological sections. in cynomolgus tongue ... | 1978 | 83317 |
| attempts to reproduce amyotrophic lateral sclerosis in laboratory animals by inoculation of schu virus isolated from a patient with apparent amyotrophic lateral sclerosis. | a virus isolated from the csf of a patient who had amyotrophic lateral sclerosis for 7 years, and prolonged pleocytosis in the csf, was adapted to suckling mouse brain by subsequent serial blind passages. this schu virus belongs to the tick-borne encephalitis complex of the genus flavivirus (togaviridae). suckling mouse brain homogenate of the 13th passage was used for transmission experiments in various species of laboratory animals. golden hamsters infected subcutaneously fell ill after a numb ... | 1979 | 84063 |
| complement profiles in monkeys subjected to aggregate (immune complex) anaphylaxis, and following injection of soluble and particulate polysaccharides. | complement profiles were established in four groups of macaca irus monkeys: (i) aggregate (immune complex) anaphylaxis was induced following immunization, with ovalbumin. upon challenge, systemic arterial pressure decreased from 115 to 50 mm hg (mean values) in 10 min. the complement profiles revealed decreases in: c1q to less than 10% of initial value within 5 min; c4 proportional to hypotension; c3 slowly to 60% at 24 h; c5, c6, c7, c8 and factor b to about 80% of initial value in 5--30 min. c ... | 1979 | 90656 |
| has myelin basic protein received a fair trial in the treatment of multiple sclerosis? | autosensitization to some central nervous system antigen still remains one of the best hypotheses for the continuing pathogenesis of multiple sclerosis (ms). enough is now known about the cause, pathogenesis, and treatment of experimental allergic encephalomyelitis (eae) to test this hypothesis. reports of therapeutic failure of the encephalitogen myelin basic protein (bp) in the treatment of ms have their counterparts in similar therapeutic failures in eae. only highly inbred strain 13 guinea p ... | 1979 | 93873 |
| myelin basic protein treatment of experimental allergic encephalomyelitis in monkeys. | treatment of experimental allergic encephalomyelitis (eae) in two strains of monkeys with large amounts of myelin basic basic protein (bp) fails unless an adjunct is also used. in both strains the adjunct by itself is more effective than bp by itself, but in the one strain which could be investigated sufficiently, the combination can be made almost totally effective in reversing eae. the adjunct varies with the strain of monkey, an antibiotic in macaca mulatta and a steroid in macaca fasciculari ... | 1979 | 93874 |
| thyroid activity in a hypometabolic primate, the owl monkey (aotus trivirgatus). | serum levels of triiodothyronine (t3) and tetraiodothyronine (t4) were significantly lower in owl monkeys than in long-tailed macaques. these observations were considered to be consistent with the lower metabolic rate of the owl monkey. however, the absence of a significant difference in the levels of thyroid stimulating hormone (tsh) between the two species suggested a lower thyroid sensitivity to tsh in the owl monkeys. there was an inverse relation between levels of t3 and tsh in the owl monk ... | 1979 | 94828 |
| aortic pulse wave velocity, elasticity, and composition in a nonhuman primate model of atherosclerosis. | aortic pulse wave velocity was determined in macaca fascicularis monkeys fed either atherogenic or control diets for 36 months. the foot-to-foot velocity and apparent phase velocities of the second through seventh fourier harmonics at a given diastolic pressure in the atherosclerotic monkeys were 1.5 to 2.0 times the values for the control animals. more than 80% of the aortic intimal surface of the atherosclerotic monkeys was covered with fibrous or fatty plaque, which approximately doubled wall ... | 1978 | 95906 |
| direct administration of methotrexate into the central nervous system of primates. part 1: distribution and degradation of methotrexate in nervous and systemic tissue after intraventricular injection. | levels of methotrexate (mtx) measured by both 3h radioactivity and dihydrofolate reductase assays were determined in cerebrospinal fluid (csf), plasma, urine, and both neural and non-neural tissues at varying times after a single intraventricular injection into cynomolgus monkeys (macaca fascicularis). clearance of the mtx from csf was rapid after injection. a relatively constant level of 3hmtx was reached in plasma 2 1/2 hours after injection, and about 30% of the 3hmtx dose was excreted in the ... | 1978 | 96228 |
| vasectomy increases the severity of diet-induced atherosclerosis in macaca fascicularis. | diet-induced atherosclerosis developed more extensively in vasectomized cynomolgus monkeys (macaca fascicularis) than in sham-vasectomized control monkeys fed the same diet. the effect was most pronounced in the abdominal aortas, carotid arteries, distal segments of the coronary arteries, and intracranial cerebral arteries. antibodies to sperm developed in all vasectomized monkeys, and complement and immunoglobulins were associated with atherosclerotic plaques in some of the vasectomized animals ... | 1978 | 96532 |
| comparison of blood groups between primates troglodytes and macaca fascicularis by use of human blood grouping antisera. | | 1978 | 97462 |
| post partum patterns of circulating fsh, lh, prolactin, estradiol, and progesterone in nonsuckling cynomolgus monkeys. | circulating levels of fsh, lh, prolactin (prl), estradiol (e), and progesterone (p) were determined by ria in four intact and four monkeys luteectomized (clx) at parturition in order to a) characterize the patterns of these hormones during the puerperium, and b) examine a possible inhibitory role of the "rejuvenated" corpus luteum (cl) on the resumption of follicle growth post partum. in both groups during the first four weeks, fsh and lh were at tonic levels typical of ovulatory cycles. recurre ... | 1978 | 97808 |
| effect of alfalfa meal on shrinkage (regression) of atherosclerotic plaques during cholesterol feeding in monkeys. | a semipurified diet containing 1.2 mg of cholesterol/cal was fed to cynomolgus monkeys (macaca fascicularis). at the end of 6 months, a group of 18 animals was killed for evaluation of atherosclerosis in the aorta and the coronary arteries. the remaining monkeys were assigned to three groups of 18 animals each and fed, during the following 18 months, semipurified diets containing 0.34 mg of cholesterol/cal with or without alfalfa meal, or a diet consisting entirely of monkey chow. a decrease in ... | 1978 | 98169 |
| genital inoculation of male macaca fascicularis with neisseria gonorrhoeae and ureaplasma urealyticum. | inoculation of the urethra, conjunctiva, pharynx, and anal canal of six male crab-eating macaques (macaca fascicularis) with urethral exudate from male patients with urethral gonorrhoea or with laboratory gonococcal strains was unsuccessful in establishing infection or producing increased polymorphonuclear leucocytes on gram stain. intraurethral inoculation with laboratory strains of ureaplasma urealyticum resulted in transiently positive urethral cultures for u. urealyticum and was associated i ... | 1978 | 98203 |
| cytochalasin b-induced structural changes in the anterior ocular segment of the cynomolgus monkey. | | 1978 | 98470 |
| observations on acute gastric dilatation in nonhuman primates. | in the years 1967-1977 we diagnosed 23 cases of acute gastric dilatation in monkeys. fourteen of these animals were macaca mulatta, five macaca fascicularis, and one each of macaca nemestrina, aotus trivirgatus, saimiri sciureus, and colobus guereza. fourteen of the animals were males, nine were females, and all were adults or subadults. mortality was 78% (18 of 23 animals). thirteen of the animals had received on anesthetic, immobilizing, or tranquilizing drug 1-2 days before developing acute g ... | 1978 | 98666 |
| the influence of dose on the pattern of conjugation of phenol and 1-naphthol in non-human primates. | 1. the pattern of conjugation of phenol and 1-naphthol was investigated in several primates; three old world species (rhesus, cynomolgus, patas monkeys), two new world species (capuchin, tamarin), and two prosimians (bushbaby, tree shrew). 2. following intra-muscular phenol or 1-naphthol (10 mg/kg), sulphation was the major conjugation in the old world monkeys and prosimians, whereas glucuronidation predominated in the new world species. 3. in rhesus and cynomolgus monkeys, sulphation decreased ... | 1978 | 98922 |
| the effect of reducing cusp height on the rate of approximal drift of cheek teeth in adult monkeys (macaca irus). | | 1978 | 99128 |
| a preliminary investigation into the identity of a major ninhydrin-positive component of dental plaque fluid from the monkey macaca fascicularis. | | 1978 | 99130 |
| cross-modal matching in the monkey (macaca fascicularis). | | 1978 | 99684 |
| kidney carcinoma in a male cynomolgus monkey (macaca fascicularis). | | 1978 | 99866 |
| the fine structural organization of the cuneate nucleus in the monkey (macaca fascicularis). | the fine structure of the cuneate nucleus of the monkey (macaca fascicularis) has been studied. the neurons were classified into three groups according to their nuclear morphology, the arrangement of the rough endoplasmic reticulum (rer) and the appearance of the golgi complexes. group i neurons had a regular nucleus and contained abundant cytoplasm in which were found well-developed rer and golgi complexes. group ii neurons had a slightly irregular nucleus and a variable arrangement of the rer ... | 1978 | 100483 |
| the effects of nisin on the microbial flora of the dental plaque of monkeys (macaca fascicularis). | | 1978 | 100489 |
| viscoelastic properties of the periodontal ligament and mucous membrane. | load deformation studies were carried out on the maxillary arches of three adult macaca irus monkeys using tooth-borne and tissue-borne plates. by means of an electronically controlled dynamometer, forces with different loading rates, creep, and simulated chewing loads were applied to the plates. the displacement was measured electronically relative to posterior teeth using a linear variable displacement transducer. the six main viscoelastic features noted by other workers for individual teeth u ... | 1978 | 100600 |
| brief communication. comparative pharmacology of norcocaine in m. mulatta and m. fascicularis. | norcocaine was administered intravenously (0.05, 0.5, 5.0 mg/kg) to three chaired unanesthetized male rhesus monkeys and to three chaired male cynomolgus monkeys. respiration rate, heart rate and rectal temperature were monitored. in the rhesus monkeys tachycardia and hyperventilation resulted. however, similar qualitative and quantitative changes were not observed in the cynomolgus species. there was a statistically significant difference in the response to norcocaine across species. these resu ... | 1978 | 100791 |
| metabolism of delta4-cis-pgf1alpha in the monkey. | this isomer of pgf2alpha is relatively resistant to metabolic degradation in the cynomolgus monkey. thus, 16-20 per cent of the amount injected was excreted unchanged in the urine. five metabolites with 20, 18, 16 and 14 carbon atoms in the skeleton were identified. the data are similar to those earlier seen in the rat and further support the idea that this analogue of pgf2alpha could have a long half-life time in the mammalian body and thus a long duration of its pharmacological actions. | 1978 | 100831 |
| hypocholesterolemic activities of lk-903 and clofibrate in miniature pigs, cynomolgus monkeys and beagle dogs. | | 1978 | 101309 |
| concentrations of oestradiol-17beta and progesterone in the peripheral plasma of the cynomolgus monkey (macaca fascicularis) in relation to the length of the menstrual cycle and its component phases. | ninety-three female cynomolgus monkeys were monitored throughout 647 menstrual cycles; 93.2% of these cycles were 22--37 days long and were normally distributed, with a mean of 29.2 days. menstrual bleeding generally lasted for 3--5 days and was not related to the length of the cycle. the levels of progesterone and oestradiol-17beta in the plasma were measured during the menstrual cycle in 30 monkeys. the concentration of oestradiol-17beta reached a mid-cycle peak on day 11 or 12 of the cycle. t ... | 1978 | 101640 |
| weight and size of the placenta in cynomolgus monkeys (macaca fascicularis). | a gross anatomical survey of the placental development was carried out in 24 cynomolgus monkeys (macaca fascicularis) of 4, 5, 6, 7, 8, 9, 10, 15 and 20 weeks of gestational age. eight of the 24 placentas examined were found to be single discoidal and the remaining 16 bidiscoidal. the weight and size of placentas of each animal were measured. the average weight of the 20th week placentas was about 94 times heavier than that of the 4th week ones; the average diameter of the former was about 5 tim ... | 1978 | 101705 |
| functional rehabilitation of ankylosed temporomandibular joints. | successful chrome-cobalt prostheses have been used to replace the condyle and glenoid fossa in six young macaca irus monkeys. in one group of two animals the left temporomandibular joint was replaced; in the second group the right joint and in the third group both temporomandibular joints were replaced. neither masticatory function nor ability to open or close the mouth was affected, and all the animals remained in excellent health, living in the colony for 9 to 10 months. a similar surgical pro ... | 1978 | 101929 |
| pulpal and periodontal effects of electrosurgery involving cervical metallic restorations. | the pulpal and periodontal effects of electrosurgery involving teeth restored with class v cervical amalgams and nonrestored teeth were evaluated in three cynomolgus monkeys. electrosurgical current was delivered for 1 second with a fully rectified unit at an output intensity consistent with normal clinical usage. experimental conditions included electrosurgery involving restored teeth, electrosurgery involving unrestored enamel, restored teeth not subjected to electrosurgery, and teeth which we ... | 1978 | 101933 |
| spermatophagy in the seminiferous tubules and excurrent ducts of the testis in rhesus monkey and in man. | the fine structure of cells capable of phagocytosing spermatozoa in the testes and epididymes of monkeys and men was studied by means of transmission and scanning electron microscopy. both resident cells, such as sertoli cells and epithelia of the rete testis, and free cells, such as macrophages (spermatophages) were found to phagocytose spermatozoa or fragments of spermatozoa in the seminiferous tubules and excurrent ducts. the spermatophages develop from precursor cells which invade the semini ... | 1978 | 102218 |
| bone growth aud development of secondary ossification centers of extremities in the cynomolgus monkey (macaca fascicularis). | the development of so-called long bones in the extremity has been studied roentgenographically in forty-seven males and fifty-one females cynomolgus monkeys bred and reared at the national institute of health. the age of the females ranged from five months to eight years and nine months, and that of the males was from four months to seven years. in addition, the fetuses of six to twenty weeks of gestation age were examined for the time of appearance of ossification centers. as the biological par ... | 1978 | 102516 |
| human and macaque mastication: a quantitative study. | significant differences exist between human and macaca fascicularis patterns of mandibular movement during mastication. macaque patterns display less asymmetry, more uniformity, and limited lateral excursions when compared to humans for mastication of the same food. different anatomical structures between the two species offer explanations of the different patterns that were observed. researchers should use caution when using macaques as models for human mastication. | 1978 | 102670 |
| ultrastructural organization of the retinal pigment epithelium of the cynomolgus monkey. | the ultrastructure of the retinal pigment epithelium of the cynomolgus monkey is described. particular interest is focused on the morphological basis for the functions of the pigment epithelium as part of the blood-retina barrier, as a metabolically active cell layer and as a participant in photoreceptor outer segment renewal. | 1978 | 103359 |
| treatment of established atherosclerosis during cholesterol feeding in monkeys. | a semipurified diet containing 43% of the calories as fat and 1.2 mg of cholesterol/cal was fed to cynomolgus monkeys (macaca fascicularis) for 6 months; the cholesterol content was reduced to 0.34 mg/cal for the next 18 months. during the latter period, the monkeys were assigned to 4 groups of 18 animals each and received the following dietary additions: a, none (controls); b, cholestyramine (5%, w/w); c, dextrothyroxine (0.003%); and d, wy-14,643 (0.45%). cholestyramine normalized plasma lipid ... | 1978 | 103561 |
| breeding of cynomolgus monkeys through successive generations by indoor cage system. | vital statistics on the breeding through successive generations were presented for the cynomolgus monkey colony of nih, tokyo. the results of this retrospective survey clearly demonstrated the third (f2) and the fourth (f3) generations could be bred and reared successfully by the indoor caged-breeding system in which either individual timed-mating or group mating procedure was adopted. several important and difficult problems involved in the production of successive generations of the cynomolgus ... | 1978 | 104074 |
| studies on acute and late stages of experimental central retinal artery occlusion in the cynomolgus monkey. i. intensity-amplitude relations of the d.c. recorded erg with special reference to the c-wave. | the main positive component of the c-wave of the erg is generated by the pigment epithelium-receptor complex, which is supplied from the choroidal circulation. occlusion of the central retinal artery (ocra) causes serious morphological damage only to the inner retina. an effect on the c-wave is therefore not primarily to be expected. in this study on five cynomolgus monkeys with unilateral, laser-induced ocra the c-wave was decreased, slightly in the early stage and markedly in the late stage. a ... | 1978 | 104542 |
| studies on acute and late stages of experimental central retinal artery occlusion in the cynomolgus monkey. ii. influence on the cyclic changes in the amplitude of the c-wave of the erg and in the standing potential of the eye. | the slow (2-3/h) oscillations of the c-wave amplitude and of the standing potential of the eye (sp) were studied in the cynomolgus monkey during the acute and late stages after experimentally induced (laser photocoagulation) occlusion of the central retinal artery (ocra). whereas the healthy control eyes showed large cyclic variations in both the c-wave amplitude and the sp, no oscillations in the c-wave amplitude were observed in the ocra eyes at any stage, and the sp oscillations were barely d ... | 1978 | 104543 |
| effect of ultrasound on testicular electrolytes (sodium and potassium). | the testes of 50 rats were placed in a cup filled with water and received 1 w/cm2 of ultrasound for 15 min. fluid was collected from the seminiferous tubules and rete testis of the treated and control groups at 1, 8, 12, and 24 hr intervals. ultrasound increased the sodium concentration in the fluid of the seminiferous tubules, decreased the sodium concentration in the fluid of the rete testis, increased the potassium concentration in the fluid of the rete testis, and decreased the potassium con ... | 1978 | 104674 |
| early lens changes in macaca fascicularis monkeys under topical treatment with echothiophate or carbachol studied by slit-image photography. | cynomolgus monkeys were given topical treatment with echothiophate or carbachol, and the lens changes were followed by slit-image photography. both drugs caused an early retrodisplacement of the anterior zone of disjunction due to swelling of the most superficial lens cortex. deeper layers of the cortex did not swell. the exact cause of the swelling is not known, but there must be a true cholinergic link. accommodation as such is not the cause, since (1) the effect was seen also in a monkey eye ... | 1979 | 104934 |
| aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys (macaca fascicularis) fed an atherogenic diet. | the effect of aspirin in the primary prevention of diet-induced atherogenesis in cynomolgus monkeys was studied. the diet consisted of 2% cholesterol and 10% butter by weight for 24 wk. six monkeys received only the atherogenic diet and five monkeys received the diet plus aspirin, 81 mg/monkey per day. aspirin did not affect plasma cholesterol levels or aortic atherosclerosis. platelet aggregation to arachidonic acid was almost completely suppressed. aspirin decreased significantly the number of ... | 1979 | 105014 |
| effects of intrafollicular administration of gonadotropins in two species of nonhuman primates using laparoscopy. | direct administration of 0.5 iu of human chorionic gonadotropin (hcg) into the matured ovarian follicles of adult female saimiri sciureus resulted in ovulation in 45% of the animals treated. when purified ovine luteinizing hormone (lh) was administered, ovulation was observed in 55% of the animals while intrafollicular injection of saline had no effect. similar injections of hcg into matured follicles of macaca fascicularis would not cause ovulation but did result in a 55% increase in menstrual ... | 1978 | 105138 |
| persistent cloaca in a cynomolgus monkey (macaca fascicularis). | a persistent cloaca was found to occur in a 15-year-old female cynomolgus monkey. this is the first case reported in a nonhuman primate. the embryological basis of this anomaly is discussed, and pertinent anatomical findings in this animal are reported which demonstrate the embryologic defect. | 1978 | 105140 |
| mandibular function in galago crassicaudatus and macaca fascicularis: an in vivo approach to stress analysis of the mandible. | single-element and/or rosette strain gages were bonded to mandibular cortical bone in galago crassicaudatus and macaca fascicularis. five galago and eleven macaque bone strain experiments were performed and analyzed. in vivo bone strain was recorded from the lateral surface of the mandibular corpus below the postcanine tooth row during transducer biting and during mastication and ingestion of food objects. in macaques and galagos, the mandibular corpus on the balancing side is primarily bent in ... | 1979 | 105147 |
| absence of indoleamine-accumulating neurons in the retina of humans and cynomolgus monkeys. | indoleamine-accumulating neurons have previously been detected in cats, rabbits, goldfish, chicken, pigeons, and cebus monkeys, and were therefore also looked for in humans and in old world monkey. cynomolgus irus. the monkey eyes were injected intravitreally with 50 microgram 5,6-dihydroxytryptamine, 5 microgram alpha-methylnoradrenaline, or both drugs simultaneously. the human retinas were incubated in either drug. previous observations on the distribution of dopaminergic neurons were confirme ... | 1979 | 105648 |
| epithelial differentiation and taste buds in the soft palate of the monkey, macaca irus. | a combination of light, transmission and scanning electron microscopy was employed to demonstrate the occurrence, arrangement and structure of taste buds in the oral mucosa of the soft palate of monkeys (macaca irus). taste buds are found in aggregates confined to 0.15 to 0.3 mm wide, round islands of keratinizing epithelium embedded in the normally non-keratinizing integument. topography, configuration and structure of these epithelial islands and their taste buds are described, and the questio ... | 1979 | 105810 |
| antibody responses in the cerebrospinal fulid of cynomolgus monkeys after intracerebral inoculation with paramyxoviruses. | cynomolgus monkeys with or without measles antibody were intracerebrally inoculated with measles or canine distemper viruses, and antibody responses in the cerebrospinal fluid (csf) were investigated. in measles antibody-free monkeys, natural infection with wild measles virus or intracerebral inoculations with two attenuated measles vaccines evoked primary antibody responses to measles virus in the sera but not in the csf. in measles-immune monkeys, intracerebral inoculation with the tycsa strai ... | 1979 | 106009 |
| cerebrovascular responses to subarachnoid blood and serotonin in the monkey. | preliminary in vitro experiments were performed to determine the serum concentration of serotonin in the monkey, and the ability of cyproheptadine to block serotonin and serum-induced contractions in monkey cerebral arteries. thirty-four cynomolgus monkeys were subsequently used to study changes in regional cerebral blood flow (cbf) obtained by the intracartoid 133xe technique, and in the angiographic cerebral arterial caliber resulting from subarachnoid injection of artificial cerebrospinal flu ... | 1979 | 106096 |
| studies of cultured human and simian fetal brain cells. i. characterization of the cell types. | explant cultures of the cerebral subventricular zone and cerebellar external germinal layer were established from fetal human, rhesus and cynomolgus monkey brains. using comparable gestational ages, the morphogenesis of the cultures from these three sources was almost indistinguishable. four cell types were distinguished by electron microscopy. germinal cells or neuroblasts were confined largely to the primary explant and extended into a transitional outgrowth region. astrocytes, which stained f ... | 1978 | 106319 |
| microbial composition of monkey dental plaque (macaca arctoides and macaca fascicularis). | the supragingival and subgingival dental plaque flora of macaca arctoides and macaca fascicularis monkeys were examined using mylar strip impressions, direct smears, and culture techniques. in smears, samples generally contained 40--50% cocci, 20--30% rods 8--20% fusiform bacteria, and 4--5% each of filaments, vibrios and spirochetes. differences in the ratios of the various bacterial groups related to age and sex were found. several monkey bacterial species were similar to those in human dental ... | 1979 | 106462 |
| menstrual cycle characteristics in chronically hemiovariectomized cynomolgus monkeys (macaca fascicularis). | circulating levels of lh, fsh, estradiol, and progesterone were measured by ria in daily serum samples throughout the menstrual cycle in five regularly cycling, chronically hemiovariectomized, adult cynomolgus monkeys. the hormonal patterns, the lengths of the follicular and luteal phases, and the overall cycle length were nearly indistinguishable from those observed in intact cycling monkeys. the findings accord with the notions 1) that in intact monkeys, the contralateral ovary contributes lit ... | 1979 | 107179 |
| experimental infection of the long-tailed macaque, macaca fasicularis with wuchereria bancrofti (rural strain). | | 1978 | 107598 |
| experimental and postexperimental effects of posteriorly directed extraoral traction in adult macaca fascicularis. | the experimental, postexperimental, and postretention effects of continuous high-pull headgear force application to the maxilla were evaluated in four adult, nongrowing macaca fascicularis monkeys. force was applied at 450 grams per side to face-bows attached to cast maxillary splints with an implanted occipital plug for anchorage. the active experimental phase lasted from 84 days to 205 days, and its effects were documented histologically, cephalometrically, and with dry skull preparations. pos ... | 1979 | 107807 |
| comparison of free amino acid pools in dental plaque fluid from monkeys (macaca fascicularis) fed on high and low sugar diets. | | 1978 | 107932 |
| between-ovary interaction in the regulation of follicle growth, corpus luteum function, and gonadotropin secretion in the primate ovarian cycle. ii. effects of luteectomy and hemiovariectomy during the luteal phase in cynomolgus monkeys. | | 1979 | 108094 |
| cynomolgus monkey model for experimental q fever infection. | a subhuman primate model was developed for study of the pathogenesis of infection with coxiella burnetii. cynomolgus monkeys (macaca fascicularis) that were exposed to 10(5) mouse median infectious intraperitoneal doses of c. burnetii in a small-particle aerosol developed clinical signs of illness and pathologic changes characteristic of q fever infection in humans. all monkeys had radiologic evidence of pneumonia by day 9. antibodies to c. burnetii were detectable by the indirect fluorescent an ... | 1979 | 108342 |
| effects of ascorbic acid deficiency and of erythorbic acid on blood components in the cynomolgus monkey. | eight male cynomolgus monkeys were fed an ascorbic acid-free total liquid diet until plasma levels decreased from a mean of 1.1 mg/dl to 0.04 mg/dl at 8 weeks. they showed no visible signs of scurvy. the animals were then given a daily oral dose of 10 mg ascorbic acid/kg body weight for 4 weeks, when the experiment was ended. four of the animals were given, in addition, 200 mg erythorbic acid/kg body weight orally each day. in all animals repletion was accomplished in two to three weeks using re ... | 1979 | 109407 |
| hyperopia and loss of accommodation following ciliary muscle disinsertion in the cynomolgus monkey: physiologic and scanning electron microscopic studies. | twenty-three cynomolgus monkeys underwent 360-degree disinsertion and retrodisplacement of the ciliary muscle in one eye. ten to 12 weeks after unilateral disinsertion, resting refraction in the "disinserted" eyes was more hyperopic than in the opposite eyes by 1.12 +/- 0.21 (mean +/- s.e.m.) diopters (p less than 0.001). accomodative responses to intramuscular pilocarpine (2 or 3 mg/kg) were 0.90 +/- 0.14 (mean +/- s.e.m.) diopters in the disinserted eyes and 13.88 +/- 0.79 diopters in the oppo ... | 1979 | 109411 |
| neonatal low-level lead exposure in monkeys (macaca fascicularis): effect on two-choice non-spatial form discrimination. | monkeys were dosed orally with 500 microgram/kg/day of lead as lead acetate from day 1 of life. no overt signs of lead toxicity were observed. at 2--3 years of age they were tested on a two-choice non-spatial form discrimination using a wgta apparatus. treated monkeys showed deficits compared to controls on a series of 20 discrimination reversals; there was no difference between the groups in the effect of a series of "overtraining" trials introduced between reversals. | 1979 | 109561 |
| immunological comparison of proline-rich proteins from human and primate parotid secretion. | antisera raised in response to proline-rich proteins purified from parotid secretions of man and the primate macaca fascicularis were employed to investigate the interrelationships of these proteins by immunodiffusion, immunoelectrophoresis and the combined use of disc gel acrylamide electrophoresis with radial immunodiffusion. the major human proline-rich proteins, prp i, prp ii, prp iii and prp iv as well as several minor proline-rich proteins cross-react with antiserum to prp i or prp iii. si ... | 1979 | 110358 |
| three methods to elicit sigma-optokinetic nystagmus in java monkeys. | sigma-optokinetic nystagmus (sigma-okn) can be elicited in awake java monkeys (macaca fascicularis) when stationary periodic visual patterns (grid of black white stripes, row of equally spaced dots) are illuminated stroboscopically. three methods were found to be useful in inducing the sigma-okn: postrotatory nystagmus, optokinetic afternystagmus (okan) following normal okn and a gradual transition from phi-movement (phi-okn) to sigma-okn. the properties found for sigma-okn in man are also prese ... | 1979 | 110612 |
| intramuscular and/or intralumbar postexposure treatment of rabies virus-infected cynomolgus monkeys with human interferon. | from 9 to 10 of 10 cynomolgus monkeys infected with rabies street virus died of rabies about 20 days postinfection (pi). symptoms of illness appeared 1 to 4 days before death. in an attempt to protect infected animals from the disease, human leukocyte interferon (hif) was administered intramuscularly (i.m.) near the site of infection or into the cerebrospinal fluid between the first and second lumbar vertebrae (i.e., intralumbarly [i.l.]). multiple hif doses given over a period of several days p ... | 1979 | 110693 |
| aqueous humor dynamics following total iridectomy in the cynomolgus monkey. | twenty-two cynomolgus monkeys underwent unilateral total iridectomy in vivo. several weeks to several months postoperatively, intraocular pressure (iop) was determined bilaterally by manometry under pentobarbital anesthesia (15 monkeys), by a minified goldmann applanation tonometer under ci-744 anesthesia (16 monkeys), and by a minified draeger applanation tonometer under light phencyclidine catalepsia (4 monkeys). mean iop in aniridic eyes was about 0.3 mm hg, or about 3%, lower than in opposit ... | 1979 | 110726 |
| a comparison of bacterial flora isolated by transtracheal aspiration and pharyngeal swabs in macaca fascicularis. | the pulmonary flora of 30 monkeys (macaca fascicularis) was sampled by the transtracheal aspiration technique and the pharyngeal swab method, and the results were compared. the transtracheal aspiration technique yielded lower numbers of bacteria in both aerobic and anaerobic cultures. the bacteria isolated by transtracheal aspiration were predominately pure culture, thereby lowering the possibility of contamination from commensal flora. bordetella bronchiseptica was isolated from 23.3% of the mo ... | 1979 | 110978 |
| hypolipidemic effects in monkeys of ml-236b, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase. | the fungal metabolite ml-236b, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coa reductase, has been shown to be significantly effective in lowering serum cholesterol levels in cynomolgus monkeys at doses of 20-50 mg/kg per day. levels of serum phospholipids and triglycerides were, however, not significantly changed by the administration of the drug. of the serum lipoprotein fractions, a beta-lipoprotein corresponding to low density lipoprotein was preferentially reduced by the drug trea ... | 1979 | 110993 |
| projection of precentral motor cortex upon nucleus medialis dorsalis thalami in the monkey. | the efferent connections of the lateral aspects of the precentral, premotor and granular frontal cortex were reexamined in 12 monkeys (macaca fascicularis) by means of anterograde labelling techniques using radioactive proline and leucine. a distinct projection of the precentral gyrus upon the paralamellar portion of the nucleus medialis dorsalis (md) was observed. the somatotopic arrangement within this projection is less well defined than within the ventrolateral thalamic complex. the facial d ... | 1979 | 111168 |
| cells of origin of the frontal projections to magnocellular and parvocellular red nucleus and superior colliculus in cynomolgus monkey. an hrp study. | cells of origin of frontal cortical projections to parvocellular and magnocellular red nucleus (mrn) and superior colliculus were identified by means of retrograde hrp transport. the cells projecting to parvocellular red nucleus (prn) are mainly located in areas 6 and 4, and are situated in the upper part of layer v, i.e. above the betz cells, while those projecting to mrn are mainly located posteriorly in area 4, and are situated deep in layer v, i.e. at the level of the betz cells. the neurons ... | 1979 | 111171 |
| toxic epidermal necrolysis in a monkey (macaca fascicularis). | an adult male macaca fascicularis monkey developed toxic epidermal necrolysis after ingestion of methylmercury. the clinical picture was characterized by the development of large cutaneous bullae with subsequent full-thickness epidermal exfoliation. areas of sparse pelage were most affected, with the most severe exfoliation occurring on the palms, soles, face and ears. erosions also developed within the oral mucosa and conjunctivae. | 1979 | 111406 |
| prostaglandin f2 alpha and its 13-dehydro analogs: comparative luteolytic effects in vivo. | prostaglandin f2 alpha (pgf2 alpha) was identified as a luteolytic hormone in sheep (nature, new biol. 238, 129, 1972). attempts to use pgf2 alpha for the pharmacological control of luteolysis in normal cycling sheep met with only partial success due to the rapid clearance of pgf2 alpha from the blood. in addition treated animals showed moderate to severe cardiovascular and gastrointestinal side effects. accordingly, experiments were carried out to determine whether pg analogs might be more effe ... | 1979 | 111476 |
| light and electron microstructure of a sarcocystis sp. from the malaysian long-tailed monkey, macaca fascicularis. | the ultrastructure of the cyst wall and zoites of a species of sarcocystis from the skeletal muscles of a naturally-infected malaysian long-tailed monkey, macaca fascicularis, is described in detail. the wavy, electron-dense primary cyst wall is thin (55 nm) and invaginated. cytophaneres are absent. the ground substance contains electron-dense granules and bundles of parallel, fibrillar elements in some areas. thin trabeculae are present. the zoites measure 1.2 x 4.7 microns and have an interior ... | 1979 | 111569 |
| echothiophate-induced structural alterations in the anterior chamber angle of the cynomolgus monkey. | four cynomolgus monkeys were treated topically twice daily in one eye with echothiophate iodide (pi) doses of 63, 75, or 250 micrograms per treatment for 7.7 weeks to 7 months. the opposite eyes of two monkeys received a control solution (diluent). the anterior ocular segments of all six eyes were studied by light and transmission electron microscopy during treatment. in the pi-treated eyes, the cribriform and outer corneoscleral meshwork were unusually dense. the trabecular meshwork was collaps ... | 1979 | 113361 |
| ultrastructure of normal monkey liver. | the normal ultrastructure of the liver of rhesus and cynomolgus monkeys is described. a classification of type a and b periportal hepatocytes is introduced together with a discussion of the high incidence of mitochondrial abnormalities. it is suggested that the rhesus monkey is more suitable as an experimental model than the cynomolgus since its liver ultrastructure is less variable. | 1979 | 113618 |
| dose-response relations for dicentric yields in go lymphocytes of man and crab-eating monkey following acute and chronic gamma-irradiations. | a comparison has been made of dicentric yields in go lymphocytes between man and crab-eating monkey, macaca fascicularis, after acute and chronic gamma-irradiations. with acute irradiation (49.6 rad/min) there was no significant difference between them, but for the chronic irradiation (17.1 rad/h) a significant difference was observed between the species. when the dose-response relations were fitted to the linear-quadratic model (y = alpha d + beta d2), the species-difference observed for chroni ... | 1979 | 113673 |
| transmission of sarcocystis suihominis from humans to swine to nonhuman primates (pan troglodytes, macaca mulatta, macaca irus). | sporocysts of sarcocystis suihominis obtained from human feces were used to infect swine. heart, tongue, and skeletal muscle from experimentally infected and noninfected control swine were fed via stomach tube to nonhuman primates including chimpanzees (pan troglodytes), rhesus monkeys (macaca mulatta), and cynomolgus monkeys (macaca irus). all primates fed infected swine tissues shed sporocysts beginning 13 to 15 days postinfection and were still shedding sporocysts at the conclusion of the exp ... | 1979 | 113949 |
| alteration in bone marrow rna of vitamin e-deficient monkey, macaca fascicularis. | in anemic crab-eating monkeys, macaca fascicularis, there is an alteration in the bone marrow rna species resulting from early vitamin e deficiency, when compared with those from normal simian bone marrow or from phenylhydrazine-induced anemic bone marrow of rabbit. anemia of vitamin e deficiency is specifically associated with a reduction in the ribosomal rna content. | 1979 | 114044 |
| sarcocystis in man: a review and report of five cases. | sarcocystis was identified in biopsy specimens of skeletal muscle from two adults in singapore and one in bombay, and in muscle obtained at autopsy from an adult in uganda, and in the heart of a child in costa rica. review of case reports revealed that in seven reported cases, including three reported by lindemann, non-parasite objects were misinterpreted as sarcocysts; in four instances organisms of undetermined classification were described, and in 35 cases true sarcocysts were observed. among ... | 1979 | 114067 |
| organization of somatic thalamus in monkeys with and without section of dorsal spinal tracts. | in an attempt to understand the modifications which appears at the thalamic level when dorsal cord sections are performed, peripheral fields of thalamic units were studied in normal and dorsal-cord sectional monkeys, totally awake and implanted with glass micropipettes. six normal macaca cynomolgus and 7 having received spinal sections, were studied. ventricular radiography was performed and all the coordinates were related to new stereotaxic coordinates using the posterior commissure as the ori ... | 1979 | 114272 |
| [study on the distribution of methyl-mercury (203hg) by whole body autoradiography of macaque monkeys (macaca irus)]. | the distribution of methyl-mercury labelled with mercury-203 has been studied in monkeys by whole body autoradiography technique. the mercury is rapidly absorbed. it is localized in all the body and mainly in well defined areas of the central nervous system. | 1978 | 114318 |
| regional cerebral blood flow thresholds during cerebral ischemia. | the development of methods of determining regional cerebral blood flow (rcbf) has made possible the determination of thresholds for the appearance of cerebral ischemia. these thresholds vary depending on the method used for assessing cerebral ischemia. the following thresholds have been determined in man and nonhuman primates: 20 cc/100 g per min, electroencephalogram (eeg) and evoked cortical potential abnormalities appear, paralysis seen in waking monkeys; 15 cc/100 g per min. eeg and evoked c ... | 1979 | 114427 |
| in vitro interaction between normal cynolmolgus monkey alveolar macrophages and legionnaires disease bacteria. | the interaction between normal cynomolgus monkey alveolar macrophages and legionnaires disease bacteria was studied by transmission electron microscopy. after ingestion of legionnaires disease bacteria, the organisms replicated within macrophages and destroyed the phagocytic cell. | 1979 | 114492 |
| experimental degeneration of primary afferent terminals in the cuneate nucleus of the monkey (macaca fascicularis). | six monkeys (macaca fascicularis) were used for the present study. in animals which survived for 2-6 days after section of c5 to t1 dorsal roots, at least four types of degenerating afferent terminal were observed - electron-dense, electron-lucent, neurofilamentous and flocculent. the electron-dense degeneration was the most common and was seen as early as 2 days after rhizotomy. the neurofilamentous type was the second commonest and was found predominantly in the 3 days' survival material. the ... | 1979 | 114509 |
| the distribution of oxytocin- and neurophysin-stained fibers in the spinal cord of the rat and monkey. | immunohistochemical methods have been used to describe the distribution of neurophysin i- and oxytocin-stained fibers in the spinal cord. in albino rats of either sex, such fibers descend through the dorsal part of the lateral funiculus to the caudal end of the cord. fibers leave the lateral funiculus to innervate the marginal zone of the dorsal horn at all levels, and the intermediolateral column at thoracic, lumbar and sacral levels. some fibers course medially through the intermediate gray to ... | 1979 | 115910 |
| surveys of simian malaria in japan. | the survey of simian malaria in japan which had been conducted since 1965 showed that no japanese monkeys (macaca fuscata fuscata and macaca fuscata yakui) were infected with malaria parasites. most interestingly, however, babesia sp. was found in 4 (4.3%) of 93 macaca fuscata yakui which had been reared in a monkey park. as for the monkeys imported from abroad, plasmodium was only found in macaca irus from southeast asia, namely, p. inui (14.1-25.0%), p. cynomologi (0.6, 3.2%) and p. coatneyi ( ... | 1979 | 116437 |