| kinetic studies and effects of anions on creatine phosphokinase from skeletal muscle of rhesus monkey (macaca mulatta). | a purification procedure for creatine kinase (ec 2.7.3.2) from muscle of the monke35--170 muequiv h+/mg protein per min at 30 degrees c and a yield of approx. 0.5 g/kg muscle. assuming equilibrium kinetics, synergistic binding of substrates at one catalytic site is found for both the forward and back reactions. kinetic constants for the binding of each substrate to the free enzyme and the enzyme-second substrate complex are determined and are compared with those for the enzyme from other species ... | 1975 | 77 |
| experimental diarrhea in cynomolgus monkeys by oral administration with clostridium perfringens type a viable cells or enterotoxin. | purified c. perfringens type a enterotoxin fed orally in an amount of 5 mg caused both vomiting and diarrhea in the monkey only when the gastric juice had been neutralized. exposure of enterotoxin to ph 4.0 or below rapidly destroyed the activity. all three monkeys receiving sodium bicarbonate and 2.4 x 10(10) viable cells grown in ds medium developed diarrhea, and only one of them vomited once. the diarrhea lasted for 13, 18 and 19 hr. the symptoms were similar to those reported in human cases ... | 1975 | 525 |
| fluroxene toxicity induced by phenobarbital. | because of reports of fluroxene toxicity in man, the effect of phenobarbital treatment on the toxicity and metabolism of fluroxene was studied in 9 rhesus monkeys. six monkeys that were exposed to a mean calculated alveolar fluroxene concentration of 5.8% for 4-hr periods up to a total of 16 hr showed no evidence of toxicity. two animals were sacrificed after a single 4-hr exposure to obtain control measures of fluroxene metabolites in tissues. four monkeys that had previously survived received ... | 1975 | 1168 |
| oxidative biotransformation of 2-acetylaminofluorene in fetal and placental tissues of humans and monkeys. correlations with aryl hydrocarbon hydroxylase activities. | the mixed-function oxidation of 14c-labled 2-acetylaminofluorene (aaf) was investigated in placental and fetal tissues of humans and monkeys (macaca nemestrina) in vitro. the major metabolite formed in most tissues was 7-hydroxy-aaf. rates of the hydroxylation reactions varied widely among the tissues investigated and were generally one to two orders of magnitude lower than those measured in rat hepatic tissues. high correlations among rates of 7-,5-, and 3- and between 1- and n-hydroxylations o ... | 1975 | 1224 |
| absorption and disposition of 2-4-(2,2-dichlorocyclopropyl)phenoxy-2-methylpropanoic acid, win 35,833, in rats, monkeys, and men. | 2-4-(2,2-dichlorocyclopropyl)phenoxy-2-methylpropanoic acid, win 35,833, was readily absorbed after oral administration; in rats, rhesus monkeys, and human volunteers, peak concentrations of drug in plasma were attained within 2 hr of medication. the time-concentration curve of administered drug was biphasic in monkeys and men, while in rats the kinetics of a one-compartment model were observed. distribution studies of 14c-labeled drug in the rat showed that most of the radioactivity was excrete ... | 1975 | 1228 |
| neurotransmitter regulation of growth hormone and acth in the rhesus monkey: effects of biogenic amines. | in an attempt to clarify the role of central neurotransmitters in gh and acth regulation, chair-adapted unanesthetized adult male rhesus monkeys and chronic indwelling intratrial cannulae were given 30 min infusions of various agonists known to affect central amines, and plasma samples were withdrawn for gh and cortisol determinations. infusion of acid-saline vehicle alone had no significant effect on plasma gh or cortisol (p less than 0.05). l-dihydroxyphenylalanine (l-dopa) (4.5 and 45 mg/kg), ... | 1976 | 2458 |
| possible participation of potassium ions in the regulation of local cerebral blood flow. | the microinjections of mock spinal fluid with various potassium concentrations into the cat and monkey brain tissue were made in acute and chronic experiments. the vascular reactions as studied with the microphotography and h-clearance method were found to be linearly related to the potassium concentrations within the range of 0--12 meq/1, being constrictory below 5 meq/1 and dilatory above that. an interaction between msf potassium and ph seems to be weak if any, since the slope of the potassiu ... | 1975 | 2506 |
| sweating responses in the rhesus monkey (macaca mulatta). | | 1976 | 3316 |
| monooxygenase-catalyzed aldrin epoxidation and dihydroisodrin hydroxylation in monkey liver needle-biopsy specimens. assay and properties. | aldrin epoxidation and dihydroisodrin (1,8,9,10,11,11-hexachloro-2,3-7,6-endo-2,1-7,8-endo-tetracyclo 6.2.1.1(3), (6).0(2), (7)dodec-9-ene (dhi) hydroxylation have been studied in 0.2-ml liver monooxygenase preparations. liver biopsy specimens of rhesus (macaca mulatta) and bonnet (m. radiata) monkeys obtained with a 1.9-mm menghini needle were the primary enzyme sources. dieldrin and monohydroxydihydroisodrin (dhi-oh) were the only metabolites detected by electron-capture glc analysis of hexane ... | 1976 | 3398 |
| the effect of a simulated subarachnoid hemorrhage on cerebral blood flow in the monkey. | the hydrogen clearance method was used to measure local and total cerebral blood flow (cbf) in the rhesus monkey before and for five hours after a simulated subarachnoid hemorrhage (sah). cbf remained stable after sah unless sah was associated with a fall in cerebral perfusion pressure. in addition, cerebrovascular resistance did not increase after sah. these results suggest that vasoactive agents in fresh whole blood, and the arterial spasm they produce when added to cerebrospinal fluid (csf), ... | 1975 | 820 |
| the effect of antihistamines on experimental posttraumatic edema of the spinal cord. | the present experiments were designed to test the effect of antihistamines on the formation of post-traumatic edema of the spinal cord. ten rhesus monkeys received 600 gm cm injuries to the t10 level of the spinal cord. five animals received antihistamine treatment and five animals acted as untreated controls. posttraumatic edema was estimated using radio-active tagged serum albumin. a significant increase in radioactivity of the injured segment was demonstrated in both groups when compared to n ... | 1976 | 4901 |
| the cholinergic system and nociception in the primate: interactions with morphine. | in experiment 1 the shock titration task was used to evaluate the antinoceptive properties of 5 different classes of cholinergic compounds in the rhesus monkey. only scopolamine and high doses of physostigmine were effective in elevating the shock threshold. the apparent antinociceptive effect of physostigmine, however, was difficult to separate from its nonspecific behavioral depressant effect and was probably not related to an increase in cholinergic tone. experiment 2 examined the interaction ... | 1975 | 708 |
| self-administration of psychomotor stimulant drugs: the effects of unlimited access. | rhesus monkeys surgically prepared with intravenous catheters were given 23 hr daily access to injection of either cocaine, d-amphetamine, 1-amphetamine, d-methamphetamine or diethylpropion on a fixed ratio 1 schedule of reinforcement for a maximum of 30 days. responding was maintained by all these drugs but showed both day-to-day and hour-to-hour variability. the two animals self-administering 0.2 mg/kg/infusion cocaine died in less than 5 days. all 6 animals given access to 0.05 mg/kg/infusion ... | 1976 | 4818 |
| the projections to the superior temporal sulcus from areas 17 and 18 in the rhesus monkey. | | 1976 | 5733 |
| the electrolyte pattern of the gastric secretion from the vervet monkey. | the output of acid, chloride, sodium and potassium in gastric washings from the vervet monkey have been measured under basal conditions and while stimulating the secretion with two doses of pentagastrin (one dose submaximal, the other dose supramaximal). the output during washings with different weak electrolyte solutions (5 meq/1 nac1, kcl, or hcl or 0.36 m glycine) are compared. the results show that the composition of the secretion was independent of the composition of the rinsing fluid in th ... | 1975 | 5809 |
| studies on fazadinium bromide (ah 8165): a new non-depolarizing neuromuscular blocking agent. | intravenous dose-response relationships were used to correlate neuromuscular paralysis with the effects of fazadinium (ah 8165) on autonomic mechanisms in anaesthetized cats and rhesus monkeys and with cardiovascular effects in man. in cats and monkeys neuromuscular paralysis of the twitch responses of the gastrocnemius muscle by fazadinium was accompanied by impairment of the vagally induced bradycardia, but cardiovascular disturbances were small. blockade of sympathetic mechanisms and hypotens ... | 1976 | 2378 |
| isolations in a mosquito (aedes pseudoscutellaris) cell line (mos. 61) of yellow fever virus strains from original field material. | a simple, rapid and inexpensive method of isolating yellow fever (yf) virus from naturally infected mosquitoes, human liver and the serum of a sentinel monkey by inoculation of a continuous line of mosquito cells is described. the mosquito cells were more sensitive than suckling mice and marginally better than vero cells for primary isolation. this is the first time that mosquito cells have been successfully used for primary isolation of yf virus from field material. | 1975 | 5385 |
| defective lipid disposal mechanisms during bacterial infection in rhesus monkeys. | mechanisms producing hypertriglyceridemia during bacterial sepsis have not been well defined. in this study lipid disposal mechanisms were assessed in 76 infected and 19 control male rhesus monkeys by the ability to dispose of triglycerides after: (1) oral lipid loading; (2) intravenous lipid loading; and (3) by lipolytic enzyme activity tests as measured by postheparin lipolytic activity (phla). studies were performed both before and 48 hr after intravenous inoculation with either salmonella ty ... | 1976 | 5648 |
| perinephritis hypertension in monkeys. i. an increase of plasma renin activity associated with increased permeability of retinal vessels and angionecrosis. | the renal parenchyma of 5 crub-eating monkeys (macaca irus) was wrapped by cellophane, and plasma renin activity, blood pressure and vascular permeability of ocular ground were measured in comparison with 5 unoperated control monkeys. the results demonstrated that increases of systolic arterial pressure, plasma renin activity, and permeability of the retinal vessels were found in 4 operated monkeys. there was no such abnormal finding in the unoperated control monkeys. generally there was a rough ... | 1976 | 6807 |
| metabolic deacetylation: in vitro and in vivo studies in man, rat, dog and rhesus monkey with isomeric tetrahydroisoquinolyl derivatives of 3,4-dimethylbenzyl acetate. | the pharmacological activities of a racemic mixture of tetrahydroisoquinolyl derivatives of 3,4-dimethylbenzyl acetate, (+/-) ro 03-4661 and the corresponding resolved isomers (+) ro 03-4661 and (--) ro 03-4661 have been studied in rat and rhesus monkey. the racemate and the (--) isomer showed narcotic analgesic activity by the oral route in both species. drug metabolism studies indicated that the activity was probably due to metabolic deacetylation to the corresponding carbinol ro 03-4632. deac ... | 1976 | 8060 |
| a comprehensive study of in vitro drug metabolism in several laboratory species. | a shortage of rhesus monkeys for use in drug toxicity studies has made it necessary to search for a potential replacement species in the event that one should be needed in the near future. to this end, 14 parameters of drug metabolism in hepatic microsomal and soluble fractions were examined in preparations from adult male and female rhesus monkeys, squirrel monkeys, hanford miniature pigs, common tree shrews, and sprague-dawley rats. model substrates were utilized and comparisons were made on a ... | 1976 | 6223 |
| mirex kinetics in the rhesus monkey. i. disposition and excretion. | three female rhesus monkeys were given 14c-mirex (5.23 mci/mmol) iv (two animals) or po (one animal) in a dose of about 1 mg/kg for the purpose of determining the distribution and excretion of this polycyclic perchlorinated insecticide. blood, plasma, urine, feces, and tissue samples were analyzed for 14c content. monkeys were autopsied 23, 106, and 388 days after receiving 14c-mirex. following iv administration, plasma 14c showed a rapid decrease over the first few hours from the initial high l ... | 1976 | 6234 |
| circulating tissue antigens. iii. identification and characterization of antigens of limited and of wide body is distribution in human gall bladder bile. presence in serum of patients with acute hepatitis. | three antigens shared by bile and tissues (bt-1, bt-2 and bt-3) and one shared by bile and saliva (ba) were identified in human gallbladder bile by immunodiffusion. the former were detected in all bile specimens examined, whereas the latter was detected only in half. bt-1 was limited in distribution to kidney, urine and bile; whereas bt-2 and bt-3 were widely distributed mainly in liver, lung and bile. the antigens were not present in biles of other mammals tested, with the exception of ba which ... | 1976 | 9219 |
| bandage-backfall reaction: occurs in infancy, hypothalamic damage, and catalepsy. | in cataleptic clinging, produced either by catecholamine-blocking drugs or lateral hypothalamic damage in adult cats, rats, or monkeys, bandaging the face and neck causes the head to fall backwards. early in development, a similar reaction can be seen in normal undrugged infants. | 1976 | 9643 |
| experimental infection of macaca mulatta monkeys with lednice (yaba 1) virus. | macaca mulatta monkeys were inoculated with lednice (yaba 1) virus strain 6118. the animals developed no clinical signs and the body temperature and values of complete haematological examination remained within normal limits. in spite of positive immunofluorescence in regional lymph nodes, no virus could be recovered from them by passages in mice. viraemia was not demonstrated. the antibody response was directly proportional to the amount of virus inoculated, i.e. it was significant after a high ... | 1976 | 9803 |
| respiratory syncytial virus-specific rna synthesis in primary monkey kidney cell cultures. | primary rhesus monkey kidney (mk) cell cultures were inoculated with respiratory syncytial virus and treated or untreated with actinomycin d before pulse labeling with uridine-5-3h. the virus-specific rna synthesis was noted at its peak in the nucleoplasm and possibly less so in the cytoplasm of infected cells. at 48 and 72 hours post-inoculation (p.i.), small fractions of available cells were synthesising virus-specific rna with labeling index of 15% and 18% respectively. by 48 hours p.i. syncy ... | 1976 | 9807 |
| autoregulation of cerebral blood flow and its relation to cerebrospinal fluid ph. | internal carotid artery blood flow (ifbf) was determined in each of nine macaca mulatta by means of a flow transducer implanted around an internal carotid artery. the monkeys were lightly anesthetized, intubated, and paralyzed. normoxia and normocarbia were maintained stable throughout the experiment. icbf was monitored while mean arterial blood pressure (mabp) was lowered by withdrawal of blood. mabp was kept within the known limits of autoregulation in order not to compromise cbf. cerebrospina ... | 1976 | 9834 |
| plasma concentrations in the monkey (macaca mulatta) of six related benzodiazepines after intraperitoneal injection proceedings. | | 1976 | 10030 |
| effects of alkali-treated proteins: feeding studies with free and protein-bound lysinoalanine in rats and other animals. | to find out whether alkali-treated proteins posses nephrotoxic properties, feeding studies were conducted with drastically treated soybean protein and casein, and also with lysinoalanine (lal), the amino acid known to be formed in protein subjected to high ph at elevated temperature. the feeding of synthesized lal to rats at dietary levels of 100 ppm and above induced typical renal changes, called nephrocytomegalia. no such changes or any other indications of toxicity were observed, however, upo ... | 1976 | 9494 |
| inversion of optical configuration of alpha-methylfluorene-2-acetic acid (cicloprofen) in rats and monkeys. | a simple and sensitive radiometric method to determine the individual enantiomers of cicloprofen has been developed. 14c-cicloprofen was converted to its l-leucine diastereoisomers, which were separated by thin-layer chromatography and quantified by measuring the radioactivity in the area corresponding to each individual diastereoisomer. this technique has also been used to measure the enantiomers of unlabeled cicloprofen by condensing with 14c-labeled l-leucine. by using the radiometric method, ... | 1976 | 8287 |
| "white-wild" (variola-like) poxvirus strains from rodents in equatorial africa. | strains of variola-like virus were isolated from rodents, namely 1 each from mastomys coucha (fam. muridae) and helioscorus rufobrachium (fam. sciuridae) in the bumba zone of the equatorial province of the zaire republic. attempts to isolate the virus from 48 monkeys were negative. neutralizing antibodies were found in 1 of 7 monkey (cercopithecus ascanius schmidti) sera examined as well as in the serum of h. rufobrachium from which the virus was isolated. | 1976 | 7947 |
| search for epizootic-like venezuelan encephalitis virus at enzootic habitats in guatemala during 1969-1971. | seventy-four strains of venezuelan encephalitis (ve) virus recovered from sentinel hamsters or mosquitoes at enzootic habitats in guatemala in the two years following the 1969 epidemic-equine epizootic were examined for ability to produce small plaques in vero african green monkey kidney cell cultures, like isolates obtained during the epizootic. (a) one strain recovered from a sentinel hamster in late october 1969 at an enzootic habitat near the epicenter of the hemagglutination-inhibition (hi) ... | 1976 | 7138 |
| a comparison of the effects of the inhalation of 4% and 8% fluroxene in the pregnant primate. | a comparison was made of the effects of inhalation of 4% fluroxene (n = 5) and 8% fluroxene (n = 5) in pregnant monkeys. measurements of maternal arterial blood pressure, heart rate, cardiac output, total peripheral resistance, uterine blood flow, fetal heart rate and arterial blood pressure, and maternal and fetal blood gas levels were made. inhalation of 4% fluroxene for 20 minutes produced little change in maternal hemodynamics and was well tolerated by the fetus. fluroxene 8% inhaled for a s ... | 1976 | 7094 |
| pneumococcal leptomeningitis in cynomolgus monkeys (macaca fascicularis). | | 1976 | 10668 |
| mirex kinetics in the rhesus monkey. ii. pharmacokinetic model. | 14c-mirex was given iv and po to female rhesus monkeys (macaca mulatta) and radioactivity was measured in plasma, urine, and feces at intervals after dosing and in tissues when animals were killed. graphical analysis of plots of the logarithm of plasma concentration vs. time was used to provide estimates of the values of the first-order rate constants required by the proposed pharmacokinetic models. a basic-language program, fitkin, was used to obtain numerical solutions to the differential equa ... | 1976 | 6235 |
| histamine-induced hypotension modified by h1 and h2 antagonists in the monkey (macaca mulatta). | blocking h2 receptors with burimamide in the dose used (20 mg/kg) approximately doubles the amount of histamine needed to produce the same effect as seen when h1 antagonists (chlorpheniramine or mepyramine) are used alone. the kz ratios for chlorpheniramine-chlorpheniramine plus burimamide are 117-204 and for mepyramine-mepyramine phus burimamide are 200-478. h1 and h2 receptors, in the monkey, when stimulated, both cause cardiovascular responses in the same direction. | 1976 | 11118 |
| the effects of hallucinogens on blind monkeys. | two blind monkeys were studied with an observational profile that was previously shown to distinguish the effects of hallucinogens from those of other classes of drugs. lysergic acid diethylamide and dimethyltryptamine could be distinguished from saline, chlorpromazine, d-amphetamine sulfate, and bromo-lysergic acid diethylamide by the increased frequency of spasms, stereotypy, bump, and tracking. the hallucinogens also produced dramatic increases in exploration and related behaviors normally se ... | 1976 | 11193 |
| physiological disposition and metabolic fate of a new antiarrhythmic agent, alpha, alpha-dimethyl-4-(alpha, alpha, beta, beta-tetrafluorophenethyl) benzylamine in the rat, dog, monkey, baboon, and man. | the physiological disposition of a new orally active antiarrhythmic drug, alpha, alpha-dimethyl-4-(alpha, alpha, beta, beta-tetrafluorophenethyl)benzylamine (mk-251) was investigated in the rat, dog, rhesus monkey, baboon, and man. mk-251 was extensively absorbed after oral administration in all species. fecal excretion was the major route of tracer elimination in the rat (70%) and dog (80%), whereas the monkey, baboon, and man excreted the majority of the dose via the urine (40-80%). mk-251 and ... | 1976 | 8295 |
| use of the mouse jumping test for estimating antagonistic potencies of morphine antagonists. | the potencies of 19 reference morphine antagonists have been compared in a modified version of the mouse jumping test. mice were each implanted subcutaneously with one 75 mg pellet of morphine. antagonist challenge took place 72 h later and the incidence of repetitive vertical-jumping was monitored over 1 h. a high pearson correlation coefficient (r = 0.997) was found between quantitative assays based on the total number of jumps per mouse and quantal assays based on mice jumping at least 6 time ... | 1976 | 6688 |
| relationship between the activity of precentral neurones during active and passive movements in conscious monkeys. | | 1976 | 11492 |
| studies on the characteristics of poliovirus type 3. iii. strain characteristics after passage in man. | the markers d, ist, ea1(oh)3 and rct at sub- and supraoptimal temperatures as well as neurovirulence (pmic) for monkeys was determined for strains isolated from children vaccinated with leon 12a1b vaccine, their contacts and from paralytic cases. the strains were isolated at early and late phases of excretion. the changes concerned mainly rct determined at supraoptimal temperatures, d and pmic markers, especially in strains isolated at the late phase of excretion. the passage through the human a ... | 1976 | 11664 |
| lung lecithin biosynthesis in the nonhuman primate fetus: determination of the primary pathway in vivo. | the two pathways for de novo lecithin (phosphatidylcholine) biosynthesis, choline incorporation (1) and phosphatidylethanolamine methylation (ii), were examined simultaneously in lung and other tissues of rhesus monkey fetuses. cannulation of interplacental fetal vessels permitted studies on the intrauterine fetus without disruption of fetal-placental-maternal-amniotic fluid anatomic integrity. in contrast to observations with indirect techniques in the same species, direct measurement of the in ... | 1976 | 8165 |
| effects of chronic administration of neuroleptics: dyskinesias in monkeys. | | 1976 | 4829 |
| studies on adrenal phenylethanolamine n- methyltransferase (pnmt) with s k & f 64139, a selective inhibitor. | sk&f 64139 is a potent, reversible inhibitor of phenylethanolamine n-methyltransferase; its ic50 concentration in our standard assay system was 1 x 10(-7) m. kinetically, the compound is a competitive inhibitor with respect to norepinephrine but is uncompetitive when s-adenosylmethionine is the variable substrate. in contrast to a previously reported compound (sk&f 7698), the drug is only a weak alpha receptor antagonist (kb = 6 x 10(-6) m). in both the rat and squirrel monkey, sk&f 64139 produc ... | 1976 | 6786 |
| pharmacokinetics and metabolism of (-)-alpha-2-3hacetylmethadol (laam) in the monkey: evidence for a new metabolite. | | 1976 | 6726 |
| monkeys with nigrostriatal lesions: tremor induced by harmaline and other drugs. | | 1976 | 4828 |
| the objective and timing of drug disposition studies, appendix v. a comparison of the bioavailability of three dosage forms of terfenadine. | antagonistic effect against histamine-induced wheals was used to evaluate the bioavailability of terfenadine in monkeys. a rapidly dissolving tablet formulation of terfenadine shows essentially identical bioavailability to a liquid suspesion. a less readily dissolving capsule formulation lags considerably in time with regard to availability, and some question remains as to whether the total quantity in the capsule is available. | 1975 | 4287 |
| distribution of prostaglandin e 9-ketoreductase and nad+-dependent and nadp+-dependent 15-hydroxyprostaglandin dehydrogenase in the renal cortex and medulla of various species. | regional distributions of pge 9-ketoreductase and 15-hydroxy-prostaglandin dehydrogenase were examined in the cytoplasmic fractions from the kidneys of seven species. all species contained an nadph-dependent reductase, as well as nad+- and nadp+-dependent dehydrogenases in both cortex and medulla. a previously unrecognized cytoplasmic nadh-dependent pge 9-ketoreductase was also detected in the cortex and medulla of rat and bovine kidney. total nad+- and nadp+-dependent dehydrogenase activity was ... | 1975 | 2961 |
| the intrinsic, association and commissural connections of area 17 on the visual cortex. | an experimental neurohistological study has been made of the intrinsic connections of the cortex of area 17 of the monkey, of the commissural connections of the visual cortex of the cat and monkey and of the association fibres passing into area 17 of the cat. in light microscopic studies the axonal degeneration method of nauta has been used, and the site and mode of termination of the degenerating fibres has also been determined with the electron microscope... | 1975 | 2937 |
| differences in the ph activity profile of human and monkey salivary lysozyme. | | 1976 | 12198 |
| combined anatomical and electrophysiological studies on the boundary between the second and third visual areas of rhesus monkey cortex. | | 1976 | 12516 |
| effects of estradiol-17beta on the induction of gonadotropin release by electrical stimulation of the hypothalamus in rhesus monkeys. | serum lh and fsh were measured at 60, 30, and 0 min before, at 5, 15, and 30 min during, and at 10, 45, and 90 min after bilateral electrical stimulation (es) of various hypothalamic regions in 12 unanesthetized ovariectomized rhesus monkeys. es of the arcuate-ventromedial nuclei (medial basal hypothalamus; mbh) induced a prompt increase in serum lh that persisted throughout stimulation and returned to basal levels within 90 min thereafter. fsh was also released, but the release was slower and l ... | 1977 | 12930 |
| distribution of four potential transmitter amino acids in monkey retina. | | 1977 | 13152 |
| assessment in the guinea-pig ileum and mouse vas deferens of benzomorphans which have strong antinociceptive activity but do not substitute for morphine in the dependent monkey. | 1 four benzomorphans which have potent antinociceptive activity in the hot-plate and writhing tests in the mouse but do not suppress or precipitate withdrawal symptoms in the morphine-dependent monkey, have been examined for their pharmacological actions in the guinea-pig ileum and mouse vas deferens. 2 in the guinea-pig ileum their agonist potencies are 1.5 to 400 times greater than that of normorphine of morphine whereas in the mouse vas deferens their potencies relative to morphine are 0.3 to ... | 1975 | 2359 |
| methanol poisoning. i. the role of formic acid in the development of metabolic acidosis in the monkey and the reversal by 4-methylpyrazole. | | 1975 | 2163 |
| fermentative digestion of food in the colobus monkey, colobus, polykomos. | fermentation of leafy food occurs in the enlarged saccus gastricus of the colobus monkey with the formation of volatile fatty acid, as in the rumen of ruminant animals. about half of the digestible organic matter and cellulose of the diet is digested in this way. | 1976 | 5288 |
| species differences in the metabolism and disposition of spironolactone. | the absorption, excretion and metabolism of 22-14cspironolactone was compared in charles river rats, beagle dogs and rhesus monkeys. the drug was administered at the fixed dose of 5 mg/kg po and iv. from the po/iv ratios of the areas under the plasma radioactivity-time curves, the gastrointestinal absorption of the drug was estimated to be 82% in the rat, 62% in the dog, and 103% in the monkey. the absolute bioavailability of a pharmacologically active metabolite, canrenone, was 57% in the dog a ... | 1976 | 11976 |
| isolation and partial characterization of an histidine-rich polypeptide from parotid saliva of the monkey, macaca nemestrina. | | 1977 | 11920 |
| effect of adsorbents on igm and igg measles antibodies. | sera from rabbits immunized with l-16 measles virus absorded with monkey blood cells; kaolin and blood cells; and mncl2 and heparin were examined in haemagglutination inhibition (hi) and neutralization tests. kaolin and mncl2 adsorbed primarily hi igm antibodies from the early immunization period. the adsorbents used had no influence on hi and neutralization igg antibodies. human convalescent serum gave similar results, i.e. only igg antibodies were found and they were not affected by kaolin and ... | 1975 | 1989 |
| characterization of nigerian strains of west nile virus by plaque formation. | seven strains of west nile virus isolated in nigeria were investigated for their ability to form plaques in monkey kidney cell monolayers. five strains antigenically related to one another produced plaques of about the same size 3 to 4 days after the addition of the overlay medium. the two other strains closely related to each other produced no plaques. their inability to produce plaques was regarded as a significant characteristic of the intratypic group to which the two strains belong. | 1975 | 1995 |
| relationships between chemical structure and antiviral activity of some biguanide derivatives. | the aim of this report was to indicate the correlation between chemical structure and antiviral activity of some biguanide derivatives obtained according to monsanto chemicals ltd. neth. appl. 289. 283. the studies were carried out on the culture of monkey kidney cells infected with parainfluenza sendai virus and on the mice infected with influenza virus. the increase of antiviral activities of n-phenylbiguanide and n-p-ethoxyphenylbiguanide was estimated. | 1977 | 14461 |
| effects of beta-adrenergic stimulating and blocking agents on the adrenaline response and adenyl cyclase activity of leukocyte in monkey and human being. | using the method in which leukocyte suspensions were incubated with naf or metaproterenol at 30 degrees c for 15-30 min to allow them to convert 3h-atp (10 muci) to 3h-cyclic amp, followed by separation of the formed 3h-cyclic amp by common chromatography, the leukocyte adenyl cyclase activity of monkeys and human beings was measured with high reproducibility. the oral administration of metaproterenol increased the leukocyte adenyl cyclase activity which was stimulated by naf and decreased the c ... | 1975 | 1868 |
| possible structural-functional organization of the system of local cerebral blood flow regulation. | rcbf under normal conditions in the rabbit, cat, and monkey brain was found to have a spontaneous periodicity while rcbf responses to afferent flicker stimulation usually revealed a double-phasic fluctuative pattern. this suggests that the rcbf regulatory system consists of not less than two regulatory chains with different time constants, and a feedback. the data on cerebral vascular responses to microapplication of mcsf solutions with various ph, potassium and catecholamines concentrations, su ... | 1975 | 1291 |
| comparative biotransformation of triflubazam in rats, dogs, and monkeys. | the biotransformation of 14c-triflubazam (orf 8063; 1-methyl-5-phenyl-7-trifluoromethyl-1h-1,5-benzodiazepin-2-4-3h,5h-dione) was investigated in rats, dogs, and monkeys. urinary metabolites, representing 65, 74, and 87%, respectively, of the total urinary radioactivity excreted by these three species, were isolated by preparative layer chromatography and characterized by various spectral techniques including gas chromatography/mass spectrometry, solid probe mass spectrometry, polarimetry, and i ... | 1975 | 1219 |
| the effects of serotonergic and adrenergic receptor antagonist on prolactin release in the monkey. | | 1977 | 14291 |
| the biosynthesis of dimethyltryptamine in vivo. | the in vivo formation of dimethyltryptamine was studied in rabbits, rats and monkeys. when c14-labelled n-methyltryptamine was administered by intravenous injection to rabbits, c14-dimethyltryptamine was found in lung, the principle site of the methyltransferase that biosynthesizes this psychotogen. unequivocal evidence for c14-dimethyltryptamine formation in rat tissues was not obtained. when rabbits were given non-radioactive n-methyltryptamine intravenously, dimethyltryptamine appeared in car ... | 1977 | 14361 |
| influence of ph on the heat inactivation of staphylococcal enterotoxin a as determined by monkey feeding and serological assay. | the effect of ph on the thermal inactivation of staphylococcal enterotoxin a was investigated. analysis of heated toxin by immunodiffusion in gel indicated that enterotoxin a in beef bouillon was inactivated faster at ph 5.3 than at ph 6.2. the z values (slopes) for the heat inactivation curves at ph 6.2 and 5.3 were 49.5 and 55 f (about 27 and 30 c), respectively. enterotoxin produced and heated in dialyzed casamino acids medium and assayed by monkey feeding was more easily inactivated by heat ... | 1975 | 950 |
| characteristics of poliovirus type 3 strains after passage through monkey central nervous system. | cercopithecus aethiops monkeys were inoculated intracerebrally with sabin's type 3 polivoirus strain, and with strains isolated from subjects vaccinated with leon 12a1b and from their contacts. sample of brain, spinal cord, kidneys, lymph nodes, blood and spinal fluid were taken. from these materials, (except of kidneys) 23 poliovirus strains of type 3 were isolated. genetic markers rct 40.3, rct 41, d and ist were determined for these strains. the changes observed in genetic markers of strains ... | 1977 | 15438 |
| gastric emptying and secretion in the rhesus monkey. | the volume and composition of the gastric contents as well as the rates of gastric emptying and secretion were determined simultaneously in conscious chair-adapted monkeys. these determinations were made during fasting and after a liquid meal, thereby allowing studies of the physiologic variables which regulate gastric emptying and gastric secretion. administration of a water meal is followed by a complex pattern of changes in rates of secretion as well as the fractional rate of emptying. during ... | 1977 | 14505 |
| human and monkey prolactin and growth hormone: separation of polymorphic forms by isoelectric focusing. | the feasibility of using isoelectric focusing for the separation of primate pituitary growth hormone from prolactin and for the characterization of polymorphic forms of these hormones was explored. in a ph 3--10 gradient, extracts of both human and cynomolgus monkey pituitaries were each resolved into 4 growth hormone components and at least 3 prolactin components, as shown by radioimmunoassay. in narrower gradients (of 2--3 ph units) greater resolution was achieved; the principal growth hormone ... | 1975 | 227 |
| phospholipase a2 as a probe of phospholipid distribution in erythrocyte membranes. factors influencing the apparent specificity of the reaction. | the action of snake venom phospholipases a2 in intact human erythrocytes was investigated in detail. the basis phospholipase from agkistrodon halys blomhifii was found to induce both hydrolysis of membrane phospholipids and total cell hemolysis under certain experimental conditions. the hydrolytic action of the basic enzyme was found to consist of two sequential events: (a) hydrolysis of 70% of the total cell ph osphatidylcholine without any evident hemolysis; and (b) complete hydrolysis of the ... | 1975 | 54 |
| drug biotransformation in microsomes from the fetal stumptailed macaque, macaca arctoides: hepatic n-demethylation. | the kinetics of the n-demethylation of benzphetamine, ethylmorphine, meperidine, and methadone have been studied in microsomes isolated from livers of the fetal stumptailed macaque (macaca arctoides) during the last third of gestation. the apparent km for each substrate did not change during this time period. values were similar to those from livers of adult african green monkeys. the vmax for each substrate, when expressed per mg of microsomal protein, did not change during the last third of ge ... | 1976 | 10140 |
| the urinary excretion profiles of naltrexone in man, monkey, rabbit, and rat. | a gas-chromatographic method has been developed for the simultaneous determination of naltrexone, alpha-naltrexol, and beta-naltrexol as trimethylsiyl derivatives. analysis of urine from rabbit, monkey, and rat demonstrated that, like man, these species reduce naltrexone primarily to beta-naltrexol. in naltrexone maintenance patients receiving 125 mg po three times per week, an average of 37% of the dose was recovered in 48-hr urine as free naltrexone (0.8%), conjugated naltrexone (7.6%), free b ... | 1976 | 10147 |
| the physiological disposition of the uricosuric-saluretic agent (6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxy)acetic acid (mk-196) in the rat, dog, and monkey. | the physiological disposition of a new saluretic-uricosuric agent, (6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxy)acetic acid (mk-196), was studied in the rat, dog, and monkey. mk-196 was well absorbed and showed minimal metabolism in these species. peak plasma levels of radioactivity and drug occurred 0.5-2 hr after oral administration at a dose of 2.5 mg/kg. essentially all of the radioactivity present in the plasma during the first day was intact mk-196. following a single dose, a long te ... | 1976 | 10149 |
| the effect of miotics on the intraocular pressure of conscious owl monkeys. | the intraocular pressure of conscious, unsedated owl monkeys (aotus trivirgatus) was measured with an applanation tonometer. untreated eyes of the conscious animals were found to have higher values than those reported for owl monkeys anesthetized with pentobarbitone. locally applied pilocarpine, carbachol, and oxotremorine gave concentration-related reduction in pressure, oxotremorine being the most potent and having longer duration of effect than the other compounds. slight reductions were also ... | 1976 | 10262 |
| malaria of the orang-utan (pongo pygmaeus) in borneo. | the primary objective of this project was to study the life cycle and ecology of plasmodium pitheci, a malaria parasite of the orang-utan. the field work was based on the orang-utan rehabilitation centre in the sepilok forest reserve of eastern sabah. two visits were made to sepilok, the first in february and march, 1972, and the second (by w.p.) in january 1974. on the first visit two species of "surrogate host" were taken to sabah, i.e. chimpanzees and aotus monkeys for experimental work. the ... | 1976 | 10589 |
| simultaneous anatomical demonstration of the representation of the vertical and horizontal meridians in areas v2 and v3 of rhesus monkey visual cortex. | | 1977 | 15268 |
| oxygen equilibrium characteristics of adult and fetal hemoglobin of japanese monkey (macaca fuscata). | adult hemoglobin and fetal hemoglobin were obtained from japanese monkey (macaca fuscata) and their oxygen equilibrium characteristics were studied. (1) the oxygen affinity of fetal hemoglobin was higher than that of adult hemoglobin both in the presence and absence of 2,3-diphosphoglycerate. the presence of diphosphoglycerate lowers the oxygen affinity of adult hemoglobin much greater than does that of hbf and the diphosphoglycerate levels of red cells of adult and newborn monkeys are about the ... | 1976 | 10977 |
| on the relation between the analgesic activity of meptazinol and its plasma concentrations in rats, mice and monkeys. | | 1976 | 11302 |
| mother-infant separation and the nature of inter-individual relationships: experiments with rhesus monkeys. | | 1977 | 15272 |
| a comparative study of the disposition of quinalbarbitone, heptabarbitone and methaqualone in the rhesus monkey (macaca mulatta) and the beagle dog (canis familiaris). | | 1977 | 15775 |
| afferent input to movement-related precentral neurones in conscious monkeys. | | 1976 | 11491 |
| variation in age at puberty in monkeys. | 5 female and 3 male patas monkeys and 6 female and 3 male talapoin monkeys matured in a captive breeding colony. age at puberty is given, and some variation discussed. the talapoin, a very small monkey, becomes adult at 4 1/2 years for females, 1 or 2 years later for males. the patas, a rather large monkey, becomes adult at 2 1/2 years, for females, and 1 or 2 years later for males. both these ages for puberty differ from data for the rhesus monkey which has been accepted as generalizable to all ... | 1977 | 18386 |
| testosterone production and metabolism in laboratory-maintained male rhesus monkeys. | plasma production rates (pr), metabolic clearance rates (mcr) and plasma levels of testosterone were determined in 10 male, laboratory-maintained rhesus monkeys on two occasions out-of-season (april and august) and once in-season (october). plasma testosterone levels in october were higher than those in april and august. the plasma pr was unchanged in august, but markedly increased in october, as compared to april. the mcr showed a parallel increase betueen august and october. thus changes in te ... | 1977 | 18415 |
| epizootiology, transmission and approach to prevention of fatal simian haemorrhagic fever in rhesus monkeys. | | 1977 | 18679 |
| histamine2--receptor blockade with cimetidine in the monkey cranial circulation. | | 1976 | 18733 |
| normal and abnormal middle ear ventilation. | studies in infants and children have suggested a functional rather than mechanical obstruction of the eustachian tube as a predisposing factor in middle ear effusions (mee). to simulate this condition in the laboratory, an animal model was prepared using juvenile rhesus monkeys. the tensor veli palatini muscle was transected or expunged posterior to the hamulus of the medial pterygoid lamina. transection of the muscle resulted in negative middle ear pressure without effusion, whereas when the mu ... | 1977 | 18977 |
| an analysis of factors influencing the isolation rate of herpes simplex virus. | attempts were made to improve the rate of isolation of herpes simplex virus (hsv) from clinical specimens by minimizing loss of virus infectivity during transportation and employing the most sensitive cells for isolation. basical analyses using standard strains of type 1 and type 2 hsv indicated that virus titer decrease was marked even at low temperatures in environments free of proteinous stabilizer such as normal serum or tissue extract, negating the generally held concept that hsv is stable ... | 1977 | 17816 |
| hydrogen ion and carbon dioxide content of the oviductal fluid of the rhesus monkey (macaca mulatta). | the ph in the oviduct lumen of adult female rhesus monkey (macaca mulatta) during the menstrual cycle was measured by means of miniaturized ph electrodes. two types were used: one was a flexible electrode 1.4 mm in diameter; the other was a rigid electrode 0.8 mm in diameter. the same results were obtained with both types. for pco2 measurements, the ph electrodes was converted to a severinghaus tyep electrode covered with a teflon membrane. during the follicular phase, the ph remains constant in ... | 1977 | 19307 |
| immune responses during measles infection in immunosuppressed rhesus monkeys. | rhesus monkeys immunosuppressed with horse anti-human thymocyte gamma-globulin (atg) were infected with measles and simultaneously inoculated with sheep erythrocytes (srbc), a thymus-dependent antigen, and with pneumococcal polysaccaride type iii (sss-iii), a thymus-independent antigen. atg treatment alone suppressed srbc antibody production, had no effect on sss-iii antibody production, and effectively eliminated circulating t cells compared to nonsuppressed monkeys. atg treatment of measles-in ... | 1977 | 19536 |
| spectral density analysis of the effects of barbiturates and benzodiazepines on the electrocorticogram of the squirrel monkey. | the effects of pentobarbital and diazepam were compared in a series of tests in squirrel monkeys; the effects of phenobarbital and flurazepam were compared in a second series. observations were made of gross behavior and on the ecog; the latter was analyzed by the spectral density technique. the two barbiturates induced sedation,which was occasionally so deep that the monkeys could not be readily aroused. the benzodiazepines induced sedation in some monkeys, but others showed signs of restlessne ... | 1976 | 11759 |
| colour coding in the superior temporal sulcus of rhesus monkey visual cortex. | | 1977 | 17866 |
| hypotensive and antiarrhythmic effects of a new alkaloid, the 13-hydroxylupanine-2-pyrrolcarbonic acid ester, from the madagascan plant cadia ellisiana. | the alkaloid 13-hydroxylupanine-2-pyrrolcarbonic acid ester (hoe 933) from the madagascan plant cadia ellisiana has an hypotensive and antiarrhythmic effect. the hypotensive effect in dogs, monkeys, and rats anaesthetized with barbiturates reaches its maximum with 0.2 mg/kg i.v. however, the hypotensive effect is much weaker in conscious animals. the enteral absorption in the dog is good; an intraduodenal dose of only 0.5 mg/kg lowered the blood pressure. in the isolated rabbit heart whose accel ... | 1976 | 11808 |
| metabolism of methoxyphenamine in man and in monkey. | metabolites of methoxyphenamine in the urine of human subjects and monkeys were separated by gas-liquid chromatography and identified by comparison of their chromatographic and mass spectrometric behavior with those of synthetic compounds. aromatic o-demethylation, aromatic ring hydroxylation (both followed by glucuronide conjugation), and n-demethylation were shown to occur in man as well as in monkey. in man these were the principal metabolites, whereas in the monkey three additional unidentif ... | 1976 | 11979 |
| comparison of thyrotropin-releasing hormone with melanocyte-stimulating-hormone-release-inhibiting factor as pentobarbital antagonists in monkeys. | thyrotropin-releasing hormone (trh), 0.1 mg/kg, i.m., significantly counteracted pentobarbital narcosis in six monkeys, but melanocyte-stimulating-hormone-release-inhibiting factor (mif), 0.1 mg/kg i.m., did not. earlier dose-response studies in unanesthetized monkeys had shown that this dose of mif stimulated motor activity; this dose of trh had shown no stimulant effect, but a higher dose depressed activity. thus, an mif dose that stimulates unanesthetized monkeys does not reverse pentobarbita ... | 1977 | 19803 |
| effect of propranolol on antinociceptive, tolerance- and dependence-producing properties of morphine in rodents and monkeys. | since an abstinence syndrome may accompany the injection of opioids in addicts pretreated with propranolol the morphine antagonistic properties of this compound were investigated. racemic propranolol did not significantly affect the antinociceptive ed50 of morphine in rodents and neither precipitated abstinence in morphine-dependent monkeys nor exacerbated the syndrome in 24 hr withdrawn monkeys. multiple doses of propranolol did not alter the development of physical dependence on morphine in mo ... | 1975 | 11999 |
| bone marrow transplantation. | improvements in the results of bone marrow transplantation for the treatment of scid may be expected by employing purified stem-cell concentrates for patients who do not have a compatible sibling available. refinements in the purification technique and its monitoring are required, however. for the same category of patients it seems worthwhile to continue attempts at restoration with liver cells from fetuses less than 12 weeks of age. in addition, full protection against infections should be prov ... | 1977 | 17188 |
| prenatal development of the visual system in rhesus monkey. | | 1977 | 19781 |
| daily changes in the blood of conscious pigs with catheters in foetal and uterine vessels during late gestation. | 1. catheters were inserted into the foetal carotid artery and maternal middle uterine artery and vein in twenty foetuses from fifteen sows, 91-105 days pregnant. blood samples were collected from foetal and maternal circulations for periods of 7-21 days after surgery.2. blood gas tensions, ph, packed cell volume (pcv) and the levels of glucose, fructose and lactic acid in conscious pigs were followed in foetal and maternal bloods during late pregnancy.3. foetal blood gas tensions, ph, pcv, lacti ... | 1977 | 20500 |
| rearing conditions which support or inhibit later sexual potential of laboratory-born rhesus monkeys: hypothesis and diagnostic behaviors. | | 1977 | 20534 |