| the effect of miotics on the intraocular pressure of conscious owl monkeys. | the intraocular pressure of conscious, unsedated owl monkeys (aotus trivirgatus) was measured with an applanation tonometer. untreated eyes of the conscious animals were found to have higher values than those reported for owl monkeys anesthetized with pentobarbitone. locally applied pilocarpine, carbachol, and oxotremorine gave concentration-related reduction in pressure, oxotremorine being the most potent and having longer duration of effect than the other compounds. slight reductions were also ... | 1976 | 10262 |
| comparative studies on dihydrofolate reductases from plasmodium falciparum and aotus trivirgatus. | dihydrofolate reductase (e.c. 1.5.1.3) from plasmodium falciparum and from its host, the owl monkey (aotus trivirgatus), were partially purified and characterized. the molecular weight of the parasite enzyme was estimated to be over 10 times as high as that of the host enzyme. the host enzyme had 2 ph optima whereas the parasite enzyme only one. the activity of the host enzyme was greatly stimulated by kcl and urea, while that of the parasite enzyme was inhibited at high concentrations of such c ... | 1979 | 44526 |
| failure of increased intracranial pressure to affect rapid axonal transport at the optic nerve head. | in owl monkeys, elevation of intracranial pressure to 500 mm. saline for 4 to 7 hours failed to cause an accumulation at the optic nerve head of protein carried by rapid axonal transport. this suggests that the block of rapid transport observed by others during papilledema may be the result of axon swelling, not its cause. alternatively, more than 8 hours may be required for intracranial pressure to show an effect, only the slow transport may be affected initially, or other factors than simple h ... | 1977 | 67095 |
| endogenous new world primate type c viruses isolated from owl monkey (aotus trivirgatus) kidney cell line. | a type c virus (omc-1) detected in a culture of owl monkey kidney cells resembled typical type c viruses morphologically, but was slightly larger than previously characterized mammalian type c viruses. omc-1 can be transmitted to bat lung cells and cat embryo fibroblasts. the virions band at a density of 1.16 g/ml in isopycnic sucrose density gradients and contain reverse transcriptase and a 60-65s rna genome composed of approximately 32s subunits. the reverse transcriptase is immunologically an ... | 1978 | 76312 |
| molecular diversity among five different endogenous primate retroviruses. | genetically transmitted retroviruses of old and new world monkeys include type c viruses isolated from baboons (m7), macaque (mac-1), and owl monkeys (omc-1) and type d viruses from langurs (po-1-lu) and squirrel monkeys (smrv, m534). each of these isolates is unrelated to the others by nucleic acid hybridization criteria and contains a unique array of virion-associated proteins which can be resolved by agarose gel filtration and polyacrylamide gel electrophoresis under denaturing conditions. th ... | 1978 | 81317 |
| papain solubilization of the epstein-barr virus-induced membrane antigen. | the epstein-barr virus (ebv)-induced membrane antigen (ma) was successfully solubilized from the membranes of viable ebv-infected raji cells by treatment with papain (5 to 6 u per 1 x 10(7) to 2 x 10(7) cells). the loss of ma from viable cells was monitored by membrane immunofluorescence and antibody-dependent cellular cytotoxicity. soluble ma was demonstrated in papain digests through inhibition of antibody-dependent cellular cytotoxicity and by inhibition of the binding of anti-ma antibodies t ... | 1978 | 81320 |
| serum electrophoretic patterns of karyotypically defined owl monkeys (aotus trivirgatus). | sera were electrophoretically separated and examined from 238 karyotyped aotus trivirgatus and 29 unkaryotyped offspring. albumin polymorphism was observed with high frequency and found to conform to a codominant allele mode of transmission. a unique alpha globulin was identified in karyotypes i, vii and unkaryotyped offspring, of which one parent was a karyotype i. this alpha globulin phenotype appears to be a dominant characteristic. | 1979 | 92594 |
| thyroid activity in a hypometabolic primate, the owl monkey (aotus trivirgatus). | serum levels of triiodothyronine (t3) and tetraiodothyronine (t4) were significantly lower in owl monkeys than in long-tailed macaques. these observations were considered to be consistent with the lower metabolic rate of the owl monkey. however, the absence of a significant difference in the levels of thyroid stimulating hormone (tsh) between the two species suggested a lower thyroid sensitivity to tsh in the owl monkeys. there was an inverse relation between levels of t3 and tsh in the owl monk ... | 1979 | 94828 |
| studies on the burma (thau.) strain of plasmodium falciparum in aotus trivirgatus monkeys. | the burma (thau.) strain of plasmodium falciparum was established in 3 aotus trivirgatus monkeys by the inoculation of parasitized blood from man. subsequently, passage from monkey to monkey was obtained through subinoculation of blood parasites to 15 aotus monkeys. anopheles freeborni mosquitoes were fed on these infections on 207 occasions; in 105 of these trials, mosquitoes became infected. a total of 335 (9.9%) of the 3,378 individual mosquitoes dissected were infected. passage of the infect ... | 1978 | 96244 |
| antimalarial activities of various 4-quinolonemethanols with special attention to wr-142,490 (mefloquine). | pilot appraisals of the activities of a selected group of 4-quinolinemethanols against acute plasmodium falciparum infections in owl monkeys indicated that compounds of this class are equally active against infections with chloroquine-resistant and chloroquine-susceptible strains and that this efficacy is not compromised by concomitant resistance to pyrimethamine, and in addition, identified three derivatives with outstanding activity (wr-226,253; wr-142,490; and wr-184,806). wr-142,490, the sec ... | 1978 | 98104 |
| some effects of progestogens, oestrogens and androgens on the ocular tension of rabbits and owl monkeys. | | 1978 | 98336 |
| subcortical projections of the dorsomedial visual area (dm) of visual association cortex in the owl monkey, aotus trivirgatus. | the efferent subcortical connections of the dorsomedial cortical visual area (dm) in the owl monkey were determined by tracing degenerating axons following lesions or by tracing axonal pathways following injection of radioactively labeled proline. areas of termination included structures which are known to receive input from many other regions of cortex such as the claustrum, putamen, caudate nucleus, reticular nucleus of the thalamus and pontine nuclei. other terminations were in subcortical st ... | 1978 | 98340 |
| double representation of the body surface within cytoarchitectonic areas 3b and 1 in "si" in the owl monkey (aotus trivirgatus). | | 1978 | 98537 |
| observations on acute gastric dilatation in nonhuman primates. | in the years 1967-1977 we diagnosed 23 cases of acute gastric dilatation in monkeys. fourteen of these animals were macaca mulatta, five macaca fascicularis, and one each of macaca nemestrina, aotus trivirgatus, saimiri sciureus, and colobus guereza. fourteen of the animals were males, nine were females, and all were adults or subadults. mortality was 78% (18 of 23 animals). thirteen of the animals had received on anesthetic, immobilizing, or tranquilizing drug 1-2 days before developing acute g ... | 1978 | 98666 |
| plasmodium falciparum and plasmodium vivax infections in the owl monkey (aotus trivirgatus). i. the courses of untreated infections. | this study, the first of three designed to determine the feasibility of using owl monkeys infected with human plasmodia in the search for new, more broadly active antimalarial drugs, dealt with the characteristics of untreated infections with eight strains of plasmodium falciparum and two strains of p. vivax. such infections, induced by standardized inocula of these strains in 1,733 monkeys, all aotus trivirgatus griseimembra, were followed from day of inoculation to death of self-cure. the viru ... | 1978 | 99055 |
| plasmodium falciparum and plasmodium vivax infections in the owl monkey (aotus trivirgatus). ii. responses to chloroquine, quinine, and pyrimethamine. | the studies described in this report were designed to determine the responses of established infections with eight strains of plasmodium falciparum and two strains of p. vivax in owl monkeys to treatment with chloroquine, quinine, and pyrimethamine. responses with these different strains ranged from cure via application of well-tolerated doses of two of the above drugs and refractoriness to treatment with maximally tolerated doses of the third, to complete resistance to maximally tolerated doses ... | 1978 | 99056 |
| plasmodium falciparum and plasmodium vivax infections in the owl monkey (aotus trivirgatus). iii. methods employed in the search for new blood schizonticidal drugs. | this report describes, illustrates, and validates the major features of a procedure designed to provide primary assessments of the activities of potential antimalarial drugs against infections with chloroquine-resistant or pyrimethamine-resistant strains of plasmodium falciparum in owl monkeys of colombian origin. studies with 14 specially selected compounds have shown that the test method has the capacity to identify and quantify diverse levels of therapeutic efficacy among agents that differ w ... | 1978 | 99057 |
| effect of falciparum malaria infection on the in vitro mitogen responses of spleen and peripheral blood lymphocytes from owl monkeys. | the response of spleen and peripheral blood lymphocytes (pbl) to mitogen stimulation with phytohemagglutinin (pha), concanavalin a (cona), and pokeweed mitogen (pwm) was determined for owl monkeys (aotus trivirgatus) experimentally infected with the vietnam-oak knoll (fvo) and the uganda-palo alto (fup) strains of plasmodium falciparum. pbl from panamanian aotus monkeys with less than 25% fvo infection responded normally to mitogen stimulation; however, increased parasitemia of 25--50% resulted ... | 1978 | 99058 |
| natural distribution of squirrel monkey retrovirus proviral sequences in primate dnas. | 3h-labelled 70s rna of squirrel monkey retrovirus (smrv) hybridized to a high degree (greater than 52%) to the dna of various tissues of two squirrel monkeys. hybridization of the same probe to dnas of other primates including new world monkeys (woolly monkey, capuchin, owl monkey), old world monkeys (rhesus, african green), apes (gibbon, chimpanzee), and human (a204 cells infected with mpmv) revealed no significant hybridization. analysis of the kinetics of hybridization indicated that smrv pro ... | 1978 | 99487 |
| vaccination of experimental monkeys against plasmodium falciparum: a possible safe adjuvant. | owl monkeys (aotus trivirgatus griseimembra) were effectively immunized against a human malaria parasite, plasmodium falciparum. two injections of antigen, primarily mature segmenters with fully developed merozoites, mixed with adjuvant (6-o-stearoyl-n-acetylmuramyl-l-alanyl-d-isoglutamine and liposomes) were administered intramuscularly at a 4-week interval. approximately 2 weeks after the second vaccination, the monkeys were challenged with the homologous strain of p. falciparum. all immunized ... | 1978 | 99814 |
| antimalarial activities of various 9-phenanthrenemethanols with special attention to wr-122,455 and wr-171,669. | pilot appraisals of the activities of 16 specially selected 9-phenanthrenemethanols against acute infections with plasmodium falciparum in owl monkeys showed that all were more active than the reference compound, wr-33,063. wr-122,455, the most active derivative, and wr-171,669, ranked sixth, were selected for study in human volunteers. to assist this undertaking, appraisals of both compounds in owl monkeys infected with various strains of p. falciparum were expanded. these assessments showed: ( ... | 1978 | 101127 |
| antimalarial activities of various 4-pyridinemethanols with special attention to wr-172,435 and wr-180,409. | pilot appraisals of the activities of 10 specially selected 2,6-substituted-4-pyridinemethanols against acute plasmodium falciparum infections in owl monkeys identified three derivatives that were two to three times as active as chloroquine against infections with a 4-aminoquinoline-susceptible strain and, at the same doses, were equally effective against infections with a strain fully resistant to treatment with maximally tolerated doses of chloroquine, quinine, and pyrimethamine. two of these ... | 1978 | 101132 |
| cell-mediated immune responses in owl monkeys (aotus trivirgatus) with trachoma to soluble antigens of chlamydia trachomatis. | the first temporal study of the cell-mediated immune responses (cmi) following ocular infections with chlamydia trachomatis is presented. we examined the cmi of owl monkeys infected with trachoma to soluble antigens of c. trachomatis by leucocyte migration inhibition (lif) and delayed hypersensitivity skin testing. delayed hypersensitivity of a systemic nature developed after a local eye infection in owl monkeys; clearance of inclusions from conjunctival cells coincided with the onset of this re ... | 1978 | 101327 |
| suppression of lymphocyte transformation by plasma from owl monkeys acutely infected with plasmodium falciparum. | plasma collected from owl monkeys during the acute phase of plasmodium falciparum infection was shown to adversely affect several in vitro responses which are considered to be correlates of cell-mediated immune functions of normal monkeys. in the presence of acute-phase plasma, response of normal monkey peripheral blood lymphocytes to stimulation with phytohemagglutinin, concanavalin a, and pokeweed mitogen was severely reduced, as was the ability of peripheral blood lymphocytes to respond to al ... | 1978 | 101455 |
| banding patterns of the chromosomes of two new karyotypes of the owl monkey, aotus, captured in panama. | two new chromosome complements of aotus trivirgatus griseimembra are described making a total of five different karyotypes observed in this subspecies inhabiting panama and the northwestern part of colombia, south america. detailed comparisons of the g-banded chromosomes of these five karyotypes suggest that the polymorphism of chromosome numbers 56 and 55 in panamanian aotus and 54, 53, and 52 in colombian aotus stems primarily from a robertsonian translocation mechanism involving pairs b13 and ... | 1978 | 101668 |
| retinal ganglion cell degeneration in experimental optic atrophy. | by ophthalmoscopic and histopathologic examinations at various intervals after retinal injury, we studied progressive ganglion cell atrophy following retinal photocoagulation in 25 owl monkey eyes. a reduced ganglion cell population was apparent within three to four weeks after the photocoagulation and was maximal by six weeks. | 1978 | 102201 |
| the identification of relay neurons in the dorsal lateral geniculate nucleus of monkeys using horseradish peroxidase. | intraaxonal retrograde transport of the protein horseradish peroxidase (hrp) was used to identify relay neurons in the dorsal lateral geniculate nucleus (lgn) of owl (aotus trivirgatus) and rhesus (macaca mulatta) monkeys. in both species, from 94.1-98.6% of the neurons within columns extending through both parvocellular and magnocellular layers were labeled following injection of hrp into striate cortex. labeled neurons were also identified in the thin ventral-most s(0) layers. although most of ... | 1978 | 102664 |
| folate antagonists. 13. 2,4-diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. | an array of nonclassical thioquinazoline analogues (viii) of methotrexate was prepared by cyclization of the requisite 2-amino-5-(arylthio)benzonitrile with chloroformamidine hydrochloride (28--79%). the aminonitrile precursors were obtained by sncl2-hcl reduction (28--99%) of the corresponding 2-nitro-5-(arylthio)benzonitriles, which were synthesized by the condensation of the appropriate 5-chloro-2-nitrobenzonitriles with various arylthiols (36--83%). many of the thioquinazolines (viii) showed ... | 1978 | 102792 |
| comparative mitogen responses of lymphocytes from colombian panamanian, and peruvian owl monkeys. | a comparative study of lymphocyte responses to various mitogens, an index of cell-mediated immune competency, was made under various culture conditions using peripheral blood lymphocytes from colombian, panamanian, and peruvian aotus monkeys. dose response curves were determined for each primate group to phytohemagglutinin, concanavalin a, and pokeweed mitogen stimulation. considerable variation in mitogen response was observed. the influence of culture media supplemented with fetal calf serum o ... | 1978 | 102870 |
| partial protection of plasmodium falciparum-vaccinated aotus trivirgatus against a challenge of a heterologous strain. | two aotus trivirgatus griseimenbra monkeys which had been immunized with the merozoite-enriched fup strain of plasmodium falciparum were protected against a primary challenge with the homologous strain. the results described here show that these two monkeys were protected against a subsequent challenge with a heterologous strain (fvo) of p. falciparum. the unimmunized control monkey died of fvo infection by day 18. | 1978 | 103450 |
| antimalarial activities of wr-194,965, an alpha-amino-o-cresol derivative. | pilot appraisals of the activities of wr-194,965 and wr-204,165, two closely related o-cresol derivatives (both mannich bases), in owl monkeys infected with the multidrug-resistant vietnam smith strain of plasmodium falciparum showed that these compounds had similar levels of efficacy. total course doses effecting 90% cures (cd(90)s) were 27 and 37 mg/kg of body weight for the respective compounds, values almost identical to the cd(90) of mefloquine (a highly promising 4-quinolinemethanol) again ... | 1978 | 103492 |
| antimalarial activities of the 4-quinolinemethanols wr-184,806 and wr-226,253. | wr-184,806 and wr-226,253, two 4-quinolinemethanols structurally similar to wr-142,490 (mefloquine), have been studied in depth in owl monkeys infected with various drug-resistant and drug-susceptible strains of plasmodium falciparum and p. vivax in an effort to provide support and guidance for projected evaluations in human volunteers. the results of these studies, confirmatory of preliminary appraisals, showed that wr-184,806 was approximately one-third as active as wr-142,490 against infectio ... | 1978 | 103493 |
| mean circulation time of fluorescein in retinal vascular segments. | mean circulation time (mct) of sodium fluorescein in retinal vascular segments was determined in healthy human volunteers, using the dye dilution technique. the fluorescein dilution curves were recorded with a two-point fluorophotometer. average mct was 3.9 seconds. the accuracy of the method was determined from repeated measurements in owl monkeys and human volunteers. no significant linear correlation was found between the mct and the cross section of the vessels feeding and those draining the ... | 1979 | 103518 |
| evaluation of five temperature-sensitive mutants of respiratory syncytial virus in primates: ii. genetic analysis of virus recovered during infection. | five temperature-sensitive (ts) mutants of respiratory syncytial (rs) virus (ts-1, ts-1 ng-1, ts-1 ng-16, ts-2, and ts-7), previously evaluated forinfectivity and virulence in chimpanzees and owl monkeys, were also assayed for in vivo genetic stability. none of the five mutants tested was completely stable genetically. thus, virus which had lost some or all of the ts property was recovered from each infected chimpanzee. significantly, each ts-1 ng-1 isolate retained some degree of temperature se ... | 1978 | 104003 |
| the mechanism of disc pallor in experimental optic atrophy. a fluorescein angiographic study. | ascending optic atrophy was produced in 13 eyes of owl monkeys (aotestrivirgatus) by retinal photocoagulation. color fundus photography and fluorescein angiography were used to study and document the evolution of nerve head abnormalities. the optic nerve heads were also studied histopathologically. except in certain instances of early transient (relative) filling defects, normal disc fluorescent patterns were preserved, despite clinically apparent optic nerve head pallor. sectorial defects did n ... | 1979 | 105695 |
| connections of areas 3b and 1 of the parietal somatosensory strip with the ventroposterior nucleus in the owl monkey (aotus trivirgatus). | anatomical tracers were injected into electrophysiologically defined sites in somatosensory cortical area 3b (si proper) and area i (posterior cutaneous field) of owl monkeys after these cortical subdivisions had been extensively explored in microelectrode mapping experiments. these mapping experiments revealed that both areas 3b and 1 contain complete and separate representations of the body surface (merzenich et al., '78). restricted injections of the retrograde tracer, horseradish peroxidase ... | 1979 | 107204 |
| experimental transmission of wuchereria bancrofti to monkeys. | infective larvae of wuchereria bancrofti from laboratory-raised culex pipiens fatigans and aedes togoi mosquitoes fed on human volunteers in jakarta, indonesia (j strain) and kinmen island, china (k strain) were introduced into taiwan monkeys (macaca cyclopis) by subcutaneous inoculation, by foot puncture, or by permitting infected mosquitoes to feed weekly on the monkeys. some animals were splenectomized and others were treated with varying regimens of immunosuppressants. necropsy was done on m ... | 1979 | 107818 |
| susceptibility of owl monkeys to plasmodium falciparum infection in relation to location of origin, phenotype, and karyotype. | the relationship among geographic origin, phenotype, karyotype, and susceptibility of owl monkeys to 2 strains of plasmodium falciparum was investigated. owl monkeys from columbia and panama were both susceptible to fatal infections with the asian fvo (vietnam-oak knoll) strain of p. falciparum. however, when inoculated with the african fup (uganda-palo alto) strain, most colombian owl monkeys developed fatal or potentially fatal (bled out with parasitemias of over 25%) infections, but panamania ... | 1979 | 109608 |
| cyclic changes in the circulating and urinary levels of ovarian steroids in the adult female owl monkey (aotus trivirgatus). | circulating levels of oestrone and progesterone were measured by radioimmunoassays in plasma samles from 5 female owl monkeys on 60 consecutive days. both steroids exhibited cyclic fluctuations and based on nadir to nadir intervals the ovarian cycle was estimated to be 15.92 +/- 0.26 days. levels of oestrone and pregnanediol-3 alpha-glucuronide were also measured in daily urine samples. the fluctuations of urinary steroids reflected those observed in plasma. ketamine sedation had no effect on th ... | 1979 | 112250 |
| inhibition of the in vitro growth of plasmodium falciparum. i. the effects of immune serum and purified immunoglobulin from owl monkeys. | sera from aotus sp. monkeys (karyotypes ii, iii, and iv) which were immune to plasmodium falciparum have been used to inhibit the in vitro growth of this human malaria parasite. culture conditions used for the assays allowed 50- to 100-fold increases in the number of a+ erythrocytes infected in a 96-hr period in control cultures. although normal monkey serum did not support growth as well as normal human serum, mixtures of normal monkey and human serum were found that did. compared to such contr ... | 1979 | 113460 |
| studies on the 2,4-diamino-6-substituted quinazolines. ii. activities of selected derivatives against infections with various drug-susceptible and drug-resistant strains of plasmodium falciparum and plasmodium vivax in owl monkeys. | four 6-thio-, one 6-sulfinyl-, and two 6-sulfonyl-substituted 2,4-diaminoquinazolines were evaluated for capacities to cure established infections with the chloroquine-resistant vietnam oak knoll and pyrimethamine-resistant malayan camp-ch/q strains of plasmodium falciparum in owl monkeys. as compared with the doses of standard drugs required for cure of infections with drug-susceptible strains or doses of the newly developed aminoalcohols required for cure of either drug-susceptible or drug-res ... | 1979 | 114065 |
| studies on the 2,4-diamino-6-substituted quinazolines. iii. the capacity of sulfadiazine to enhance the activities of wr-158,122 and wr-159,412 against infections with various drug-susceptible and drug-resistant strains of plasmodium falciparum and plasmodium vivax in owl monkeys. | previous studies showed: 1) that the activities of the 2,4-diamino-6-substituted quinazolines. wr-158,122 and wr-159,412, against plasmodium falciparum and plasmodium vivax infections in owl monkeys, were seriously impaired when infecting strains were pyrimethamine-resistant; and 2) that primary treatment failure with either agent led frequently to emergence of parasites resistant to these derivatives. taking advantage of the potencies of wr-158,122 and wr-159,412 as dihydrofolic acid reductase ... | 1979 | 114066 |
| ultrastructural studies on the replication of herpes virus ateles-73 in owl monkey kidney cells. | the replicative cycle of herpesvirus ateles, strain 73 (hva-73), was examined in the electron microscope and compared to that of other herpesviruses known to be oncogenic. a relatively slow replicative cycle of hva-73 in owl monkey kidney (omk) cells allowed us to distinguish cytoplasmic and nuclear stages of replication, comprising virus uptake, transport, maturation, and extrusion. virus uptake was observed within 10 hours of infection and occurred both as a result of fusion between virus and ... | 1979 | 114147 |
| subcortical projections of six visual cortical areas in the owl monkey, aotus trivirgatus. | subcortical projections of six visual cortical areas (areas 17 and 18, the middle temporal, dorsomedial and medial areas, and the posterior parietal region) in the owl monkey, aotus trivigatus, were investigated with autoradiographic methods following injections of tritiated proline. no contralateral projections were demonstrated. while some brainstem structures received input from all six subdivisions of cortex, each cortical area appeared to exhibit its own unique pattern of subcortical projec ... | 1979 | 114555 |
| the inferior pulvinar complex in owl monkeys: architectonic subdivisions and patterns of input from the superior colliculus and subdivisions of visual cortex. | patterns of connections with other visual structures and architectonic characteristics were used to subdivide the inferior pulvinar complex of owl monkeys into three distinct nuclei termed the central inferior pulvinar, ipc, the medial inferior pulvinar, ipm, and the posterior inferior pulvinar, ipp. ipc occupies about 70%; ipm about 20%, and ipp about 10% of the inferior pulvinar complex. encapsulating fiber bands distinguish the boundaries of the three nuclei. ipm is also identified by a much ... | 1979 | 114556 |
| pregnancy diagnosis in owl monkeys (aotus trivirgatus): evaluation of the hemagglutination inhibition test for urinary chorionic gonadotropin. | the subhuman primate pregnancy test was evaluated as a means of detecting urinary chorionic gonadotropin to aid in pregnancy diagnosis in owl monkeys. using radioimmunoassay, the excretion pattern of chorionic gonadotropin from pregnant owl monekys was delineated, the hormone being detected from 16 weeks prepartum until birth. by comparison, the pregnancy test kit detected chorionic gonadotropin between the fourteenth week prepartum and the last week of gestation with 94% accuracy. in a 2-year s ... | 1979 | 116070 |
| long-term observations of proton-irradiated monkey eyes. | fifteen owl monkeys (30 eyes) that received proton irradiation of discrete areas of the retina and choroid have been observed for 3 1/2 years or more after irradiation. the dose delivered to the retina varied from a single dose of 1,600 to 4,750 proton rads and from 10,250 to 18,250 rads delivered in five fractions over a period of one month. fundus examination, fluorescein angiography, and light and electron microscopy revealed chorioretinal changes at the area of irradiation. the part of the r ... | 1979 | 116637 |
| gestation and inter-birth intervals in the owl monkey (aotus trivirgatus griseimembra). | a single, timed mating indicated a gestation period of 133 days for aotus trivirgatus griseimembra. this figure is confirmed by approximate correspondence with minimum inter-birth intervals, results from radioimmunoassay of urinary oestrogens during pregnancy, and general agreement with a logarithmic plot of gestation period against body weight for simian primates. birth data indicate that owl monkey females in present colonies in captivity breed throughout the year and will, on average, produce ... | 1979 | 116944 |
| effect of sequential infection with plasmodium vivax and p. falciparum in the aotus trivirgatus monkey. | aotus trivirgatus monkeys with prior experience with plasmodium vivax were inoculated with p. falciparum via the bites of infected mosquitoes. the animals with prior malaria had higher parasitemias and significantly higher levels of mosquito infectivity than monkeys with no prior p. vivax experience. monkeys with a history of p. falciparum that were inoculated with p. vivax had essentially the same parasitemias as those with no prior malaria. however, levels of mosquito infectivity were markedly ... | 1979 | 117086 |
| studies on the west african i strain of plasmodium falciparum in aotus trivirgatus monkeys. | the west african i strain of plasmodium falciparum was isolated from a commercial airline pilot who had an overnight stay in nigeria. once established in the aotus trivirgatus griseimembra monkey, the parasite produced high parasitemias and readily infected mosquitoes. anopheles freeborni and an. maculatus mosquitoes transmitted the infection to additional animals. infected salivary glands were also seen in an. culcifacies. comparative infectivity studies indicated the most susceptible mosquito ... | 1979 | 117091 |
| folate antagonists. 15. 2,3-diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. | oxidation of an array of 2,4-diamino-6-(arylthio)quinazolines provided the corresponding arylsulfinyl and arylsulfonyl analogues. a variety of these nonclassical analogues of methotrexate exhibited suppressive antimalarial activity superior to that of the parent thioquinazolines against drug-sensitive lines of plasmodium berghei in mice and p. gallinaceum in chicks, and several displayed potent prophylactic activity against p. gallinaceum. the sulfinyl- and sulfonylquinazolines also retained ant ... | 1979 | 117107 |
| antimalarial properties of floxacrine, a dihydroacridinedione derivative. | evaluations of the activities of floxacrine [7-chloro-10-hydroxy-3-(4-trifluoromethylphenyl)-3,4-dihydroacridine-1,9(2h, 10h)-dione] in owl monkeys infected with trophozoites of a chloroquine-quinine-resistant strain of plasmodium falciparum, a strain of this plasmodium resistant to both of these quinolines and pyrimethamine, or a strain of p. vivax resistant only to pyrimethamine showed that: (i) this compound regularly effected temporary clearance of parasitemia at daily doses of 1.25 to 2.5 m ... | 1979 | 117747 |
| respiratory syncytial virus infection in owl monkeys: viral shedding, immunological response, and associated illness caused by wild-type virus and two temperature-sensitive mutants. | intranasal inoculation of owl monkeys with wild-type respiratory syncytial virus induced upper respiratory tract disease in each of seven animals. the response of owl monkeys to two highly defective, temperature-sensitive, multiple-lesion mutants was then compared to the pattern seen with wild-type respiratory syncytial virus. these mutants, ts-1 ng-1 and ts-1 ng-16, were derived from the ts-1 mutant that had been remutagenized with nitrosoguanidine (ng). previously the ts-1 ng-1 and ts-1 ng-16 ... | 1979 | 118925 |
| cortical projections of the medial visual area in the owl monkey, aotus trivirgatus. | the cortical projections of the medial area (m) of the owl monkey were studied using the autoradiographic method. area m projects to several extrastriate areas, including area 18, in a pattern of terminations unlike that which would be expected if m was part of a larger area 19 or v iii band. the pattern of terminal lamination was found to be somewhat unusual in that projections were to layers vi, i and the deep portion of layer v in the major target areas. | 1979 | 119191 |
| visual capacities of the owl monkey (aotus trivirgatus): temporal contrast sensitivity. | aotus monkeys were tested in a forced-choice discrimination task to determine their ability to discriminate sinusoidally flickering lights varying in temporal frequency and luminance contrast. under conditions of moderate light adaptation this primate is maximally sensitive to lights flickering at 10 hz while the highest frequency they can discriminate is about 42 hz. at very low light levels (10(-5) ft l) maximum sensitivity is for 2.2--5 hz flicker. the highest flicker rate that could be discr ... | 1979 | 120301 |
| infectivity of plasmodium simium to aotus trivirgatus monkeys and different anophelines. | infections of plasmodium simium were induced in splenectomized and intact aotus trivirgatus griseimembra monkeys by parasitized blood and by sporozoites from anopheles freeborni mosquitoes. eleven of 13 monkeys developed infection after sporozoite inoculation; prepatent periods ranged from 11 to 25 days (mean 15.8 days). comparative infectivity studies indicated that an, freeborni mosquitoes were the most susceptible followed by an. stephensi, an. balabacensis balabacensis, an. maculatus, an. qu ... | 1979 | 120434 |
| immunization of aotus trivirgatus against plasmodium falciparum with irradiated blood forms. | five owl monkeys, aotus trivirgatus, were immunized against falciparum malaria by the intravenous injection of gamma-irradiated parasitized blood from donor monkeys with high parasitaemias. each animal received approximately 1 x 10(8) parasitized erythrocytes per immunizing dose. three monkeys received 4 doses and 2 monkeys received a single dose. after challenge, 3 control monkeys that received saline and the 2 monkeys that received a single dose of parasitized blood died with fulminant parasit ... | 1979 | 120764 |
| immunization of experimental monkeys against plasmodium falciparum: use of synthetic adjuvants. | the replacement of freund's adjuvant by a possible safe adjuvant for effective immunization of owl monkeys (aotus trivirgatus griseimembra) against a human malaria parasite, plasmodium falciparum, has been investigated. experiments involved the use of two synthetic adjuvants: mdp (n-acetylmuramyl-l-alanyl-d-isoglutamine) and stearoyl-mdp (6-o-stearoyl-n-acetylmuramyl-l-alanyl-d-isoglutamine). in both cases, p. falciparum merozoites obtained through short-term in vitro cultivation were used as an ... | 1979 | 120768 |
| a study of cellular and humoral immune responses in owl monkeys (aotus trivirgatus) following vaccination against plasmodium falciparum. | vaccination of animals against malaria parasites is thought to induce two basic immunological responses: (i) specific recognition of parasite antigens by the host, and (ii) a generalized immune enhancement due to the presence of adjuvant. immunological techniques were used in this study to monitor cellular and humoral immune changes in owl monkeys prior to and following immunization with a vaccine consisting of merozoite-enriched schizonts of plasmodium falciparum and one of three adjuvants: n-a ... | 1979 | 120772 |
| an experimental approach to the study of intraocular toxocara canis. | an experimental study of nematode endophthalmitis due to t canis and review of the literature has been presented. six owl monkeys were infected either by nasogastric tube using embryonated t canis eggs or by carotid or intravitreal injection of second stage larvae. the clinical manifestations, especially ocular, were observed and various diagnostic tests performed. only minimal or no intraocular changes were seen after systemic infection but significant abnormalities such as retinal hemorrhages ... | 1979 | 120993 |
| effect of argon and krypton laser irradiation on the normal owl monkey vitreous. | | 1979 | 121323 |
| choroidal edema associated with retinal detachment repair: experimental and clinical correlation. | experimental owl monkey data and prospective clinical data is presented, demonstrating the correlation of serous-choroidal edema with the extent of vortex obstruction and the additive factors of sudden hypotony from drainage and cryotherapy. older eyes are more susceptible for developing this phenomenon of choroidal edema. the extreme extent of vortex venous stasis is that of venous stasis anterior segment ischemia demonstrated in two clinical cases. | 1979 | 121324 |
| [electroretinogram in the nocturnal prosimian perodicticus potto]. | there is histological evidence for the presence of cones in potto's retina: about 1 cone for 300 rods. the erg of the dark adapted animal resembles that of the night monkey. in the potto's retina some red sensitive elements respond to wavelenghts beyond those which affect visual purple. the erg evoked by these long wavelenghts differs from that produced by white light, suggesting a duplex character of the retina. these red sensitive receptors dark adapt faster than the others. however their fusi ... | 1975 | 132262 |
| [hypometabolism in aotus trivirgatus (primates, plathyrhini, cebidae)]. | the standard metabolism of aotus trivirgatus (night monkey, owl monkey) is 22.5 to 46.2 per cent below kleiber's prevision curve for mammals, which applies to other cebid monkeys like saimiri sciureus and alouatta. however the metabolic rate of aotus is not reduced to the extent found in two hypometabolic prosimians perodicticus potto and nycticebus coucang. the low metabolism in aotus is associated with a normal body temperature and a thick fur of high insulating power. these results are discus ... | 1977 | 146561 |
| spontaneous lymphoma associated with herpesvirus saimiri in owl monkeys. | two cases of lymphoma and one case of lymphoproliferative disease were found in a group of 7 owl monkeys imported into our colony as a single group. herpesvirus saimiri (hvs) was isolated from the tumor cells of 1 lymphoma by cocultivation and from kidney cell cultures from the monkey with lymphoproliferative disease. antibody to hvs was found in serum samples from 2 monkeys positive for hvs but not in the sera from the 4 clinically normal monkeys. antibody to epstein-barr virus-infected cells w ... | 1975 | 163336 |
| depression in lymphocyte response to general mitogens by owl monkeys infected with herpesvirus saimiri. | the effect of herpesvirus saimiri (hvs) infection on the response of owl monkey lymphocytes to general mitogens was examined during the development of neoplastic disease. the reactivity of the lymphocytes was then correlated with the clinical condition of the infected monkeys and the content of virus rescued from the peripheral blood lymphocytes (pbl). eight monkeys developed lymphoma which, in six monkeys, was accompanied by lymphocytic leukemia. all animals that died of hvs-induced neoplasia c ... | 1975 | 164565 |
| pilot experiments with eb virus in owl monkeys (aotus trivirgatus). iii. serological and biochemical findings in an animal with reticuloproliferative disease. | nucleic acid hybridization with eb virus complementary rna has demonstrated unequivocally that eb virus dna is present in the cells of a continuous lymphoblastoid line established in culture from a pathological lymph node of an owl monkey with reticuloproliferative disease after inoculation with eb virus. there were 48 to 49 eb virus genome equivalents per cell. in addition, serological studies showed that the diseased owl monkey developed specific antibodies to eb virus capsid antigens. the ant ... | 1975 | 165147 |
| replication of herpesvirus saimiri in cultured lymphocytes of infected owl monkeys (aotus trivirgatus). an electron microscopic and immunofluorescent study. | the lymphocytes of five owl monkeys infected with herpesvirus saimiri (hvs) and three control monkeys were studied. lymphocytes were separated on ficoll-hypaque gradients, incubated in suspension cultures, and prepared for electron microscopic and immunofluorescent study at 24, 48, and 72 hours after the beginning of culture (ac). buffy coats of whole blood immediately after bleeding were also prepared for study. at the time of the study, four of the five infected monkeys had died of malignant l ... | 1975 | 165331 |
| immunity to chlamydial infections of the eye. iv. immunity in owl monkeys to reinfection with trachoma. | in a study of trachoma in owl monkeys, it was found that owl monkeys are equally susceptible to low and high doses of trachoma and that resistance to reinfection persisted for six months in the majority of animals. previous infections with a single trachoma type did not elicit greater resistance than previous infections with two types. both serum antibodies and eye secretion titers correlated well with resistance to reinfection, but it is not as yet clear if either or both play a substantial rol ... | 1975 | 166634 |
| mitochondrial and herpesvirus-specific deoxypyrimidine kinases. | to characterize and compare the thymidine (tdr) and deoxycytidine (cdr) kinase isozymes of uninfected and herpesvirus-infected cells: (i) the subcellular distribution of the isozymes has been studied; (ii) a specific assay for cdr kinase has been devised; (iii) the tdr kinase isozymes have been partially purified; and (iv) the purified enzymes have been analyzed by disc polyacrylamide gel electrophoresis, isoelectric focusing, and glycerol gradient centrifugation and by substrate competition and ... | 1975 | 169387 |
| augmentation of lymphocyte cytotoxicity by antibody to herpesvirus saimiri associated antigens. | sera from owl monkeys infected with herpesvirus saimiri (hvs) mediated antibody-dependent lymphocyte cytotoxicity (adlc) against virus-infected owl monkey kidney cells. peripheral blood lymphocytes from rhesus monkeys served as effector cells in this cytotoxic assay. adlc titers increased along with membrane immunofluorescence (mf) titers but among some sera, the adlc titers were much higher than expected from the mf titers, suggesting that multiple serum factors were involved in mediating adlc ... | 1975 | 169525 |
| spontaneous herpesvirus saimiri lymphoma in owl monkeys. | three examples of spontaneous malignant lymphoma were observed in owl monkeys 23, 81, and 183 days after arrival in our laboratories. the pathological features of the disease were analogous to experimentally induced herpesvirus saimiri lymphoma. h. saimiri was recovered from 2 animals (it was not attempted from one case) and one isolate was shown to reproduce characteristic h. saimiri malignant lymphoma. each monkey originated in peru in contrast to our usual source of owl monkeys which originat ... | 1975 | 169813 |
| comparisons of surface markers on herpesvirus-associated lymphoid cells of nonhuman primates and established human lymphoid cell lines. | herpesvirus saimiri (hvs)-owl monkey lymphoid cells were found to have high levels of surface receptor for sheep erythrocytes and erythrocytes of 3 other species. these hvs-lymphoid cells lacked a receptor for modified complement. lymphoid cells of one hvs-owl monkey line showed evidence for the presence of surface immunofluorescent staining with anti-kappa chain serum. cells of an established hvs-marmoset lymphoid line had similar surface markers. of 4 established human lymphoid cell lines, all ... | 1975 | 169815 |
| nonhuman primate models for lymphoma, leukemia, and other neoplasms. | herpesvirus saimiri (hvs) is an oncogenic virus for a variety of nonhuman primates. hvs does not produce overt disease upon inoculation in the natural host (squirrel monkey) but consistently induces neoplasms including lymphomas and lymphocytic leukemias in 4 other species of monkeys. various drugs inhibit replication of hvs in vitro including cytosine arabinoside and adenine arabinoside. in addition, the lymphoma and leukemia induced in owl monkeys responds to vincristine and prednisolone, cycl ... | 1975 | 169836 |
| inhibition of the mitogenic response of normal peripheral lymphocytes by extracts or supernatant fluids of a herpesvirus saimiri lymphoid tumor cell line. | a herpesvirus saimiri-infected marmoset lymphoid cell line (mlc-1) was examined for the presence of soluble factors which might affect lymphocyte functions and, therefore, relate to the pathogenesis of lymphoma in vivo. mlc-1 cells, cell extracts, and culture fluids were shown to reduce the spontaneous deoxyribonucleic acid (dna) synthesis of normal peripheral blood lymphocytes and to completely inhibit their response to phytohemagglutinin (pha). suppression of pha response was demonstrated agai ... | 1975 | 172449 |
| experimental horizontal transmission of herpesvirus saimiri from squirrel monkeys to an owl monkey. | herpesvirus saimiri was naturally transmitted from squirrel monkeys excreting the virus to one of two owl monkeys housed in the same cage. the owl monkey became infected approximately three months after contact was initiated. h. saimiri was consistently isolated from the peripheral lymphocytes until this animal died eight months later. during this period the owl monkey developed specific antibody to h. saimiri to a maximal neutralization index of 5.5 logs. the other monkey remained uninfected fo ... | 1975 | 172563 |
| purification of herpesvirus saimiri and properties of the viral dna. | conditions for growth, concentration, and purification of herpesvirus saimiri were determined. optimal yields of infectious herpesvirus saimiri (hvs) were obtained from infected owl monkey kidney (omk) cells grown at 32.5 degrees c in medium containing 10 per cent fetal calf serum. forth-five percent of the initial infectious hvs was recovered after an 18-fold concentration using 8 per cent polyethylene glycol 6000 in the presence of 0.5 m nacl. polyethylene glycol concentrated hvs was purified ... | 1975 | 174525 |
| immune response of monkeys to lymphotrophic herpesvirus antigens. | herpesvirus saimiri induces leukemia and/or malignant lymphoma when inoculated into different species of nonhuman primates including marmosets and owl monkeys. no malignant disease, however, has been recognized in the natural host for this virus, the squirrel monkey, although a high percentage of these monkeys are chronically infected with h. saimiri. furthermore, one species of marmosets, as well as capuchin and some owl monkeys, fail to develop lymphoma following experimental virus infection b ... | 1976 | 175927 |
| pilot studies with human interferon in herpesvirus saimiri-induced lymphoma in owl monkeys. | the nature of herpesvirus saimiri-induced disease in owl monkeys is described with emphasis on those biological parameters useful in monitoring the disease. these parameters are lymphocyte response to general mitogens, lymphocyte-infective centers, and antibody to virus-associated early antigen. human interferon was used in treating owl monkeys with virus-induced leukemia. in 2 animals evidence was obtained that suggested a positive antileukemic effect. | 1976 | 175932 |
| primate kidney function in hemorrhagic shock as influenced by dibutyryl cyclic amp. | standardized hemorrhagic shock was employed to study alterations in electrolyte and water handling in the owl monkey, either normally hydrated or moderately dehydrated. increase in fractional clearance of osmolarity,sodium, and calcium occurred with retransfusion after the hypotensive phase. in the hydrated animals, free-water clearance became positive, and the urine-to-plasma osmolarity ratio [(u/p)osm] decreased below 1.0. in the dehydrated animals, free-water reabsorption (tch2o) decreased bu ... | 1976 | 178188 |
| evidence for suppressor cell activity associated with induction of herpesvirus saimiri-induced lymphoma. | peripheral blood lymphocytes (pbl) from herpesvirus saimiri (hvs) infected owl monkeys lose their ability to respond to pha during the development of lymphoma. in this study, five hvs-infected owl monkeys were examined for their ability to respond to pha and to confer this loss of pha reactivity to normal lymphocytes. four of the monkeys developed hvs-induced disease and lost their ability to respond to pha. although less affected, reduced responses were also found with pwm. the animals which de ... | 1975 | 178474 |
| comparative studies with different strains of epstein-barr virus in owl monkeys and marmosets. | | 1975 | 183693 |
| correspondence between t cell suppression and adlc titers during herpesvirus saimiri (hvs) infection in owl monkeys. | | 1975 | 183696 |
| antibody responses to membrane antigens in monkeys infected with herpesvirus saimiri. | the antibody response to herpesvirus saimiri (hsv)-induced membrane antigens (ma) was followed in hsv-infected owl monkeys using the membrane immunofluorescence (mf) and antibody-dependent lymphocyte cytotoxicity (adlc) assays. these responses were correlated with the loss of t-cell responsiveness to general mitogens. antibody titers to ma as determined by adlc but not mf increased to remarkably high titers in those monkeys that developed malignant disease following virus infection, while remain ... | 1976 | 186415 |
| chronic herpesvirus saimiri infection in an owl monkey. | an adult owl monkey (aotus tricirgatus) used for immunologic studies of herpesvirus saimiri (hvs) developed early, late, membrane, and neutralizing antibodies to hvs approximately 3 weeks after the beginning of the experiment. hvs was isolated by the cocultivation of peripheral blood for over 1 year. no clinical, gross, or histopathologic findings of malignancy were exhibited by the animal. the hvs isolate from the animal was indistinguishable biologically and serologically from the original hvs ... | 1976 | 186615 |
| sequential immunofluorescence and infectivity studies on the replication of herpesvirus saimiri in owl monkey kidney cells. | methods are described for the preparation and authentication of a highly specific antiserum against herpesvirus saimiri (hvs) capsid antigens. the antiserum was used in immunofluorescence tests to follow the development of capsid antigens in hvs-infected owl monkey kidney cells throughout the virus replication cycle in parallel with sequential titrations of virus infectivity in both cells and medium. fluorescence was detected as a round or oval, bright green area of staining at the centre of the ... | 1977 | 188981 |
| absence of horizontal transmission of herpesvirus saimiri between experimentally infected and noninfected owl monkeys. | we did not detect cell-free herpesviurs saimiri (hvs) in the oropharyngeal secretions of owl monkeys with leukemia or lymphoma induced by this virus. these animals failed to transmit either virus or disease to their uninoculated cage-mates or room-mates. comparison of oropharyngeal secretions of hvs from owl monkeys and squirrel monkeys may provide insight as to how human herpesviruses are maintained in the oropharynx. | 1976 | 189906 |
| microbial agents of the owl monkey (aotus trivirgatus). | a survey of the microbial flora in the owl monkey (aotus trivirgatus) has led to the isolation of numerous bacterial, fungal, and viral agents. some of the bacterial and fungal agents, particularly dermatophilus, pasteurella, salmonella, shigella, yersinia, streptococcus, staphylococcus, and candida are known pathogens. viruses belonging to the herpesvirus, adenovirus, paramyxovirus, and papovavirus groups have been isolated from the owl monkey. most of these viruses were recovered as latent age ... | 1976 | 190470 |
| glomerulonephritis in the owl monkey (aotus trivirgatus): ultrastructural observations. | the kidneys of 11 clinically healthy owl monkeys (aotus trivirgatus) acquired from four different sources were examined by light and electron microscopy. eight of the 11 animals had morphologic evidence of glomerulonephritis. the lesions were characterized by one or more of the following changes: focal or segmental thickening of the glomerular basement membrane; proliferation of mesangial cells with increased production of mesangial matrix; and fibrosis and hyalinization of glomeruli with and wi ... | 1976 | 190471 |
| the owl monkey (aotus trivirgatus) as an animal model for viral diseases and oncologic studies. | the owl monkey (aotus trivirgatus) has been shown to be an excellent model for studies of oncogenic and non-oncogenic viruses. studies at this institution have been primarily concerned with herpesvirus saimiri, the epstein-barr virus, h tamarinus, and h simplex. these studies have shown that h saimiri is oncogenic when inoculated into primates, that the malignancy induced by h saimiri can be naturally transmitted from the squirrel monkey to the owl monkey, that in vitro pathogenicity of h saimir ... | 1976 | 190472 |
| studies of cultured lymphocytes of the owl monkey (aotus trivirgatus) infected with herpesvirus saimiri. | the lymphocytes of five owl monkeys (aotus trivirgatus) infected with herpesvirus saimiri and three control monkeys were studied. lymphocytes were separated on ficoll-hypaque gradients, incubated in suspension cultures, and prepared for electron microscopic and immunofluorescent study at 24, 48, and 72 hours after the beginning of culture. buffy coats of whole blood obtained immediately after bleeding were also prepared for study. at the time of the study, four of the five infected monkeys had d ... | 1976 | 190473 |
| eb virus in the owl monkey (aotus trivirgatus). | owl monkeys (aotus trivirgatus) were inoculated with eb (epstein-barr) virus-containing material or virion-free control material. one out of three animals given the virus died after 14 weeks with a reticuloproliferative disease compatible with malignant lymphoma. a cell line was established from an abnormal lymph node of the diseased monkey and was found by electronmicroscopy to carry a herpesvirus identified as eb virus by two types of immunofluorescence test, by its biological behavior and by ... | 1976 | 190474 |
| ultrastructural and immunofluorescent studies of the replication of herpesvirus saimiri in cultured lymphocytes of infected owl monkeys. | the lymphocytes of five owl monkeys infected with herpesvirus saimiri (hvs) and of three control owl monkeys were studied by electron microscopic (em) and immunofluorescent (if) techniques. buffy coats of whole blood immediately after bleeding were also prepared for study. at the time of the study, two of the five infected monkeys were leukaemic; within 50 days after the study, four of the five had died with malignant lymphoma and lymphocytic leukaemia. hvs virions were demonstrated by em and hv ... | 1975 | 191352 |
| isolation and characterization of lymphocyte associated foamy virus from a red uakari monkey (cacajao rubicundus). | a syncytium-forming virus was isolated from the lymphocytes of a uakari monkey 70 days after establishing a lymphocyte/owl monkey kidney coculture in the wild. the morphology and morphogenesis of the virus, plus its physicochemical characteristics indicate that the agent is a foamy virus. an unusal cell alteration found in cultures infected with this foamy was the formation of eosinophilic intracytoplasmic inclusion in association with the syncytia. the agent was found to be antigenically distin ... | 1976 | 191616 |
| lamella-particle complexes in nuclei of owl monkey kidney cells infected with herpesvirus saimiri. | a complex consisting of ribosome-like particles and a striated lamella occurring in stacked, tubular, and twisted ribbon-like configurations was observed in the nuclei of confluent monolayer cultures of primary owl monkey kidney cells infected with herpesvirus saimiri. they were similar to the cytoplasmic cylindroid structures seen in some human leukemias and in the lymphoma of the northern pike. | 1977 | 192900 |
| effects of catecholamines on the intraocular pressure of conscious owl monkeys. | | 1977 | 194860 |
| solubilization and characterization of herpesvirus saimiri-induced membrane antigens. | treatment of herpesvirus saimiri (hvs)-infected owl monkey cells by limited papain digestion removed the hvs-induced membrane antigen (ma) as determined by membrane immunofluorescence and antibody-dependent lymphocyte cytotoxicity (adlc). soluble antigenically active hvsma was detected by inhibition of adlc and by the decreased binding of 125i-labeled staphylococcus protein a to hvs-infected cells after absorption of an anti-ma-positive serum with papain extracts. approximately 38% of the inhibi ... | 1978 | 205674 |
| brain tumors in owl monkeys inoculated with a human polyomavirus (jc virus). | owl monkeys were inoculated intracerebrally, subcutaneously, and intravenously with jc, bk, or sv40 virus. two of four adult owl monkeys inoculated with jc virus, a human polyomavirus, developed brain tumors at 16 and 25 months after inoculation, respectively. a grade 3 to grade 4 astrocytoma (resembling a human glioblastoma multiforme) was found in the left cerebral hemisphere and brainstem of one monkey. the second monkey developed a malignant tumor in the left cerebral hemisphere containing b ... | 1978 | 211583 |
| augmentation of the in vitro mitogenic response of owl monkey peripheral blood lymphocytes by levamisole and loss of this effect with the development of herpesvirus saimiri-induced lymphoma. | levamisole (lms) has been shown to be capable of enhancing the proliferative response of normal owl monkey peripheral blood lymphocytes (pbl) to pha, and, to a lesser degree, of increasing the level of spontaneous dna synthesis. with the development of herpesvirus saimiri-induced lymphoma, these stimulatory responses were lost. lms was not capable of stimulating tumour cells to normal functions, or of reversing the disease-induced suppressed functions on normal cells. | 1978 | 213219 |
| potential for immunization against herpesvirus infections with plasma membrane vesicles. | virus-free, membrane antigen (ma)-positive plasma membrane vesicles produced from herpesvirus saimiri-infected owl monkey cells were used as immunogens in cotton-top marmosets. neutralizing antibodies as well as antibodies to ma and hvs-induced la were induced following immunization of marmosets with these vesicles. preliminary findings demonstrated that immunized marmosets were significantly less susceptible to tumour induction by hvs than control animals. | 1978 | 221369 |