| bacterial and mycoplasma flora of a laboratory colony of the common marmoset (callithrix jacchus). | a survey was carried out to characterise the bacterial and mycoplasma flora of a closed colony of marmosets, callithrix jacchus. bordetella bronchiseptica and staphylococcus aureus were the only potential bacterial pathogens isolated from the colony; candida albicans was also identified. s aureus and c albicans were the only organisms which were associated with macroscopic lesions or overt disease. post mortem examination of the animals proved only reliable method of establishing the presence of ... | 1978 | 102075 |
| the effects of gonadectomy and oestradiol-17 beta on pituitary responsiveness to lh-rh in the adult male marmoset (callithrix jacchus). | exogenous luteinizing hormone-releasing hormone (lh-rh) administered in a wide range of doses (0.2-25 micrograms) to intact male marmoset monkeys induced a marked increased in plasma luteinizing hormone (lh) concentrations. maximum lh concentrations achieved after injection of lh-rh occurred progressively later as the dosage increased. bilateral orchidectomy sigificantly enhanced pituitary responsiveness to a standard dose (2.0 microgram) of lh-rh, whereas the introduction of oestradiol-17 beta ... | 1979 | 116001 |
| the effect of an immunosuppressive drug (azathioprine) on the latent infection of marmoset monkeys (callithrix jacchus) with the oncogenic herpesvirus saimiri. | callithrix jacchus (cj) marmoset monkeys can be latently infected with herpesvirus saimiri (hvs). in order to determine whether this resistance to the oncogenic potential of hvs could be due to the immune surveillance, azathioprine, a known immunosuppressive drug, was given to 7 latently infected cj marmosets. the animals died within 147 days probably from side effect caused by azathioprine, but no animal developed a tumor. | 1975 | 170499 |
| epstein-barr virus: experimental infection of callithrix jacchus marmosets. | eight common marmoset monkeys (callithrix jacchus) were inoculated with about 10(4) transforming units of b95-8 virus; seven of the marmosets died 50-111 days post inoculation and all seven showed microscopic and/or macroscopic lesions compatible with a diagnosis of lymphoproliferative disease. low levels of anti-vca antibodies were detected in plasma from six marmosets. attempts failed to establish continuous ebv-carrying lymphoblastoid cell cultures by cultivation in vitro of circulating lymph ... | 1976 | 181333 |
| in vitro transforming activity of ebv. i-establishment and properties of two ebv strains (m81 and m72) produced by immortalized callithrix jacchus lymphocytes. | in vitro transformation of callithrix jacchus marmoset lymphocytes was achieved with a nasopharyngeal carcinoma (npc) derived epstein-barr virus (ebv) strain, hkly-28. two permanent and virus producing lymphoblastoid cell lines, m81 and m72, were obtained. comparison between the original hkly-28 line and both m81 and m72 lines showed that passage in the marmosets lymphocytes greatly enhanced viral production and transforming activity of the virus as observed in cottontop derived b95.8 lymphoblas ... | 1976 | 187263 |
| susceptibility of common marmosets (callithrix jacchus) to oncogenic and attenuated strains of herpesvirus saimiri. | adult common marmosets, inoculated with either of 2 oncogenic herpesvirus saimiri (hvs) strains, developed fatal lymphoproliferative disease within 23-25 days post inoculation (pi). the disease was identical to hvs-induced lymphoma in cotton-topped and white-lipped marmosets. common marmosets inoculated with an attenuated hvs strain developed persistent infection; virus has been recovered from cocultivated lymphocytes of these animals for more than 384 days pi. | 1977 | 198565 |
| studies with the baboon endogenous virus and its pseudotype of murine sarcoma virus in marmosets. | three marmoset species (saguinus oedipus oedipus, s. fuscicollis, callithrix jacchus) failed to show evidence of infection or disease following inoculation of baboon endogenous type-c virus (baev). cells infected with a kirsten murine sarcoma-baev pseudotype (msv[baev]) produced a progressive fibrosarcoma in s. o. oedipus and tumors in s. fuscicollis and c. jacchus which regressed. tumor formation is believed to be due to growth of inoculated, virus-infected cells and not transformation of marmo ... | 1978 | 205851 |
| overview of viral oncology studies in saguinus and callithrix species. | marmoset monkeys are highly susceptible to tumor induction by type c sarcoma viruses and primate lymphotropic herpeviruses. six experimental models were reviewed, three sarcoma models induced by rous, feline or simian sarcoma viruses and three models of lymphoproliferative disease induced by herpevirus saimiri, h. ateles or epstein-barr virus. relative susceptibility of cotton-topped (saguinus oedipus oedipus), white-lipped (s. nigricollis, s. fuscicollis subspecies) and commone (callithrix jacc ... | 1978 | 205860 |
| experimental infection of callithrix jacchus marmosets with herpesvirus ateles, herpesvirus saimiri, and epstein barr virus. | we inoculated common marmosets (callithrix jacchus) with herpesvirus ateles (hva), herpesvirus saimiri (hvs), and epstein-barr virus (ebv). hva-induced tumors contained several cell types, including giant cells reminiscent of the sternberg-reed cells observed in human hodgkin's disease. hvs and ebv did not induce tumors, although hvs was present in lymphocytes and elicited a strong antibody response. ebv elicited only a variable antibody response. we feel that more common marmosets should be use ... | 1978 | 208678 |
| [callithrix jacchus infection with junin virus. new experimental model in argentinian hemorrhagic fever]. | | 1978 | 216877 |
| in vitro transforming activity of epstein-barr virus (ebv). ii. differences between m81 and b95-8 ebv strains. | lymphocytes from 38 human cord blood and 9 adult circulating blood were aliquoted and infected in parallel either with the b95-8 ebv strain (produced by cotton-top marmoset lymphocytes transformed by ebv originating from an infectious mononucleosis line) or with the m81 eb virus (produced by callithrix jacchus marmoset lymphocytes transformed by ebv originating from a nasopharyngeal carcinoma (npc) derived line). significant differences were observed in the lymphoblastoid lines obtained and invo ... | 1979 | 224964 |
| a positive feedback effect of oestradiol on lh release in the male marmoset monkey, callithrix jacchus. | subcutaneous injections of oestradiol benzoate in oil, resulting in a sustained elevation of circulating oestradiol levels, induced an initial suppression of lh secretion, followed by a positive discharge of lh in castrated male and female and in intact male marmosets. oestrogen-induced lh release (producing maximum lh concentrations 24 h after the injection) was observed in 75% of castrated males and females. a positive discharge of lh occurred in 50% of intact males 28-36 h after oestrogen adm ... | 1978 | 413918 |
| metabolism and autoradiographic distribution of delta-8- and delta-9-tetrahydrocannabinol in some organs of the monkey callithrix jacchus. | metabolism and autoradiographic distribution of the two isomeric tetrahydrocannabinols, (2,4-14-c)-delta-8-thc and (2,4-14-c)-delta-9-thc, were studied in the marmoset callithrix jacchus. of the two cannabinoids, delta-8-thc had a slower initial rate of biotransformation to the psychopharmacologically more potent 11-hydroxylated metabolite. this may explain the minor psychopharmacological activity of the delta-8-isomer. in glandular tissues an accumulation of unchanged delta-9-thc was observed. ... | 1975 | 806815 |
| ultrastructure of adult and juvenile marmoset (callithrix jacchus) sertoli cells in vivo and in vitro. | the morphologic differentiation of sertoli cells isolated from adult and juvenile marmosets and cultured on different extracellular matrices was evaluated by light and electron microscopy and compared to cells in vivo. both cell types could be maintained in culture for at least 6 days. the degree of cellular differentiation, shape, ultrastructural appearance, and polarity seemed to benefit from laminin-coated substrata, compared with collagen-, fibronectin-, serum-, and heparan sulfate-coated su ... | 1992 | 1293135 |
| effects of gonadectomy and oestradiol treatment on plasma luteinizing hormone concentrations in the marmoset monkey, callithrix jacchus. | a heterologous double-antibody radioimmunoassay for marmoset lh is described in detail. the system uses niamdd rat lh-i-1 for iodination, niamdd rat lh-rp-1 as standard and anti-ovine rabbit lh 610v serum. the assay measures the level of marmoset lh in plasma and shows a maximum cross-reaction (b/bo = 50%) of 0.3% with other rat, human or bovine pituitary hormones. the heterologous assay has been applied to the measurement of the level of lh in the marmoset after gonadectomy and after the subseq ... | 1978 | 415104 |
| argentine hemorrhagic fever: a primate model. | experimental junin virus infection of a new world primate, callithrix jacchus, was evaluated. the virus produced anorexia, loss of weight, thrombocytopenia, leukopenia, and hemorrhagic and neurological symptoms and terminated in death. virus was recovered from urine, blood samples and all tissues taken at autopsy. these preliminary observations show that several aspects of the experimental disease in c. jacchus are quite similar to severe natural argentine hemorrhagic fever of man. | 1979 | 227811 |
| density distribution, characterization, and comparative aspects of the major serum lipoproteins in the common marmoset (callithrix jacchus), a new world primate with potential use in lipoprotein research. | qualitative, quantitative, and comparative aspects of the serum lipoprotein profile in the common marmoset (callithrix jacchus), a new world primate, are described. density gradient ultracentrifugation was used to evaluate lipoprotein distribution and to establish criteria for isolation of discrete molecular fractions. the major lipoprotein classes banded isopycnically on the gradient with the following hydrated densities: vldl, d less than 1.017 g/ml; ldl, d = 1.027--1.055 g/ml; hdl fraction i, ... | 1979 | 227447 |
| pregnancy diagnosis in the common marmoset (callithrix jacchus jacchus). | abdominal palpation of the uterus was carried out on 25 pregnant and 29 non-pregnant marmosets (callithrix jacchus jacchus). 195 complete 24-hour urine specimens, collected between the first week of gestation and term (21 weeks), were tested with the sub-human primate tube (shpt) test. no significant differences between the two methods in their ability to diagnose pregnancy were obtained between the first and 13th week of gestation. the shpt test was seldom positive after the 13th week of pregna ... | 1979 | 120302 |
| ureaplasmas in the marmoset (callithrix jacchus): transmission and elimination. | all adult marmosets tested had ureaplasmas in their throats but not in the lower respiratory tract, and rarely in the genital tract. ureaplasmas persisted in the throat of a marmoset separated from the colony for 44 days. they could not be recovered from the animals for at least nine weeks after a course of minocycline. airborne reinfection did not occur when these animals were surrounded by, but separate from, infected marmosets. it occurred when the minocycline-treated animals were caged with ... | 1979 | 119862 |
| peripheral plasma levels of progesterone, oestradiol-17 beta, oestrone, testosterone, androstenedione and chorionic gonadotrophin during pregnancy in the marmoset monkey, callithrix jacchus. | concentrations of lh/cg, androstenedione and testosterone rose in early pregnancy to maximum values at 6--10 weeks. thereafter lh/cg levels declined and androstenedione and testosterone levels remained at plateau values or declined until term. progesterone, oestradiol-17 beta and oestrone increased after ovulation and remained high throughout pregnancy. at 12 weeks, when lh/cg levels were falling, progesterone and oestradiol rose well above the luteal-phase levels which were maintained for the f ... | 1979 | 112249 |
| threat, attack and flight elicited by electrical stimulation of the ventromedial hypothalamus of the marmoset monkey callithrix jacchus. | in order to elucidate whether relatively primitive primates show a similar topological organization of substrates mediating defense and flight within the ventromedial hypothalamus as has been found in other mammals, 15 marmosets (callithrix jacchus) were chronically implanted with a total of 57 electrodes for electrical stimulation. experiments took place in a familiar environment and under systematically altered conditions. all anatomical sites yielding vocal threat and short attacks were found ... | 1978 | 100172 |
| aggression and flight behaviour of the marmoset monkey callithrix jacchus: an ethogram for brain stimulation studies. | the aggressive and flight behaviour of the common marmoset monkey (callithrix jacchus) is described and split into behavioural units, allowing analysis of agonistic behaviour evoked by electrical stimulation of the hypothalamus. the social context of the described units is also considered. c. jacchus shows clearly recognizable behavioural patterns. free-born animals are very timid and show typical flight reactions. within aggressive behaviour, two types of aggression can be distinguished: very v ... | 1978 | 100171 |
| plasmodium knowlesi in the marmoset (callithrix jacchus). | common marmosets were shown to be susceptible to plasmodium knowlesi malaria. the morphology of the parasite was indistinguishable from the observed in the natural host (macaca fascicularis) and the common laboratory model (macaca mulatta). a differential susceptibility to p. knowlesi was observed in the 8 marmosets studied. multiplication rates of parasites were variable over 24 h periods. five animals died of a fulminating infection within 12--17 days after challenge. three animals recovered s ... | 1979 | 33359 |
| cellular localization of tyrosine hydroxylase mrna and cholecystokinin mrna-containing cells in the ventral mesencephalon of the common marmoset: effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. | in situ hybridization histochemistry was used to localize tyrosine hydroxylase (th) mrna and cholecystokinin (cck) mrna-expressing cells in the ventral mesencephalon of the common marmoset (callithrix jacchus) and to examine the effects of the dopaminergic (da) neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) on these two populations of neurons in the pars compacta of the substantia nigra (snc) and ventral tegmental area (vta). x-ray film and liquid emulsion autoradiography of bra ... | 1992 | 1347634 |
| effects of oestradiol-17 beta on fsh-stimulated steroidogenesis in cultured marmoset granulosa cells. | a role for oestradiol in ovarian follicular development is well recognized. however, a number of disparate effects have been reported for the action of oestradiol in the primate ovary. to investigate this further, we have examined the effects of oestradiol on the differentiation of granulosa cells isolated from small (0.5-1 mm) antral follicles obtained from the ovaries of prepubertal marmoset monkeys (callithrix jacchus). granulosa cells were co-cultured with oestradiol and human fsh (hfsh) for ... | 1992 | 1310713 |
| the mossy fiber terminals in the hippocampal formation of callithrix jacchus: comparative and evolutionary considerations. | the distribution of mossy fiber terminals in the regio inferior of the hippocampus of callithrix jacchus was studied by means of timm's method. the topographic distribution of timm-positive zones in the hilus, in the suprapyramidal and intrapyramidal areas of the ca3 subfield is described. a timm-positive reaction in intragranular strips and supragranular zones, the presence of timm-negative zones in the infragranular border of the fascia dentata were found in this species. a comparison between ... | 1992 | 1284794 |
| nbqx (6-nitro-sulfamoyl-benzo-quinoxaline-dione) and cpp (3-carboxy-piperazin-propyl phosphonic acid) potentiate dopamine agonist induced rotations in substantia nigra lesioned rats. | degeneration of dopaminergic nigrostriatal neurons in primate models of parkinson's disease (pd) leads to an overactivity of excitatory glutamatergic projections from the subthalamic nucleus (stn) to the output nuclei of the basal ganglia resulting in rigidity and akinesia. the selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (ampa) antagonist 6-nitro-sulfamoyl-benzo-quinoxaline-dione (nbqx) and the competitive n-methyl-d-aspartate (nmda) antagonist 3-carboxy-piperazin-propyl phosp ... | 1992 | 1280793 |
| the excretion of steroids by the adult marmoset monkey (callithrix jacchus). | | 1975 | 829965 |
| the embryology of the common marmoset (callithrix jacchus). | earlier studies have noted the unusual placental anatomy of marmosets and the high frequency of biovular, synchorial twinning. the maintenance of a captive colony of callithrix jacchus has enabled further studies to be made of embryonic development in this species. thirty-six embryos from seventeen pregnancies were examined in detail and assigned to horizons on the basis of streeter's classification of external form and internal structure. the specimens represented tha major part of the embryoni ... | 1976 | 827927 |
| an outbreak of shigellosis in laboratory marmosets and tamarins (family: callithricidae). | an outbreak of shigellosis due to shigella sonnei, is reported in laboratory maintained marmosets (callithrix jacchus) and tamarins (saguinus nigricollis). the clinical signs and pathological lesions are described and the microbiological findings discussed. control of the disease was based upon hygiene and antibiotic therapy and the consequences of this approach are described in detail. | 1976 | 819574 |
| influence of dexamethasone on the rm 3/1-positive macrophages in the peripheral blood and tissues of a new world monkey (the marmoset callithrix jacchus). | subcutaneous injection of the glucocorticoid dexamethasone in the primate callithrix jacchus increased the proportion of the macrophage subtype rm 3/1 in the blood from a basic level of 16% positive monocytes to about 65%. the elevated numbers of rm 3/1-positive cells were seen 24 and 72 h after application and were independent of the dosages used (50 or 150 micrograms/kg). oral administration had no effect. cd4-, cd14- and cdw14-antigen expression of monocytes was not influenced by the dexameth ... | 1992 | 1582709 |
| autoradiographic studies on the distribution of 3h-mescaline in the brain of the marmoset, callithrix jacchus. | autoradiographs of the brain of the marmoset, callithrix jacchus, show a strong labeling of the hippocampus and the n. amygdalae 18 h after injection of 3h-mescaline. a similar characteristic autoradiographic pattern was previously found in the mouse brain, too. | 1976 | 815928 |
| yersinia enterocolitica infections in non-human primates. | yersinia enterocolitica was isolated from ten non-human primates in the netherlands. the following species were represented: potto, senegalgalago, wooly monkey, black spider monkey, common marmoset, cottonhead tamarin, pigtailed macaque and lesser whitenosed guenon. | 1977 | 418633 |
| identification and characterization of the herpesvirus saimiri oncoprotein stp-c488. | the protein encoded by herpesvirus saimiri transforming gene stp-c488 was identified and characterized. antibodies were produced in rabbits by immunization with keyhole limpet hemocyanin-conjugated synthetic peptides specific for the predicted sequence of stp-c488. stp-c488-encoded protein was detected in recombinant escherichia coli, transformed rat-1 cells, transfected cos-1 cells, and in common marmoset t lymphocytes immortalized by herpesvirus saimiri strain 488. stp-c488 protein was sensiti ... | 1991 | 1658384 |
| use of the common marmoset, callithrix jacchus, in reproductive research. | a self-sustaining colony of common marmosets, callithrix jacchus, was established for reproductive research. methods of management were developed to ensure optimal breeding conditions for marmosets in captivity. studies of the reproductive biology and endocrinology of this species suggest that the common marmoset may be a suitable model for the human in certain aspects of the ovarian cycle, pregnancy, puberty and the hypothalamic and pituitary control of luteinizing hormone secretion. the rapid ... | 1978 | 417331 |
| physical, hormonal and behavioural aspects of sexual development in the marmoset monkey, callithrix jacchus. | measurements of growth, plasma progesterone and testosterone levels, and copulatory behaviour were obtained from captive marmosets from birth until 600-800 days of age. body weight and knee-to-heel length were similar for both sexes. males exhibited a neonatal testosterone surge from 15-100 days and testosterone levels began to rise again, coincident with the growth of the testis, at about 250 days. the males were copulating by 400-500 days of age. paired females were apparently ovulating and ab ... | 1978 | 417178 |
| composition of the milk of the common marmoset (callithrix jacchus) and milk substitutes used in hand-rearing programmes, with special reference to fatty acids. | analyses of marmoset (callithrix jacchus) milk were carried out to determine values for crude protein, lactose, total lipids, major minerals, and osmotic pressure. mean values were (g/100 ml): protein, 3.6; lactose, 7.5; total lipids, 7.7; minerals (mg/100 ml): sodium, 21.4; potassium, 54.3; calcium, 92.2; phosphorus, 22.8; magnesium, 5.0; chloride, 52.2; osmotic pressure, 354 mosm/kg water. similar analyses were conducted on 2 milk substitutes used in hand-rearing programmes. fatty acid analyse ... | 1978 | 417007 |
| isolation of an arenavirus from a marmoset with callitrichid hepatitis and its serologic association with disease. | callitrichid hepatitis (ch) is an acute, often fatal viral infection of new world primates from the family callitrichidae. the etiologic agent of ch is unknown. we report here the isolation of an arenavirus from a common marmoset (callithrix jacchus) with ch by using in vitro cultures of marmoset hepatocytes and vero-e6 cells. enveloped virions 67 to 133 nm in diameter with ribosomelike internal structures were seen in infected cultures. immunofluorescence and western immunoblot analysis using c ... | 1991 | 1712856 |
| [autoradiographic studies on the distribution of 14c-piracetam in the simian brain]. | autoradiography of the brain of the monkey callithrix jacchus 2 and 6 h after oral application of 200 mg 14c-piracetam/kg (2-oxo-pyrrolidine-l-acetamide-2-14c) shows that the drug is preferably concentrated in the cortex of cerebrum and cerebellum. this specific affinity of piracetam which was observed earlier in dog and rat is thus confirmed in the primate and seems to be species independent. beside the dominant cortical concentration there is a characteristic storage of piracetam in many nucle ... | 1978 | 415743 |
| differences in fatty acid composition of various tissues of the marmoset monkey (callithrix jacchus) after different lipid supplemented diets. | 1. the fatty acid composition of different muscles, organs and blood components of the marmoset monkey were examined after long-term feeding of several well defined lipid supplemented diets. 2. similarities between the fatty acid composition of cardiac and skeletal muscles which persisted after all diets suggest that biopsy of skeletal muscle may have an important diagnostic value in this and other primate species. 3. the relationship between the dietary intake of individual fatty acids and thei ... | 1992 | 1348468 |
| urinary excretion of biologically active chorionic gonadotrophin by the pregnant marmoset (callithrix jacchus jacchus). | no significant correlation exists between the amount of biologically active marmoset chorionic gonadotrophin (mcg) in urine and results obtained with an immunological pregnancy test. the pregnant marmoset excretes large amounts of oestrogenic steroids, which must be removed, to prevent the enhancement of the response of the bioassay for mcg. more than 99% of these unconjugated and conjugated urinary oestrogens can be removed by extraction with acetone and ether. mcg is excreted throughout pregna ... | 1977 | 414981 |
| metabolism of anabolic steroid drugs in man and the marmoset monkey (callithrix jacchus)--i. nilevar and orabolin. | | 1977 | 410996 |
| the establishment of specified-pathogen-free marmosets, callithrix jacchus. | the establishment of 3 specified-pathogen-free marmosets (callithrix jacchus) during the period may 1969 to january 1973 is described. a brief history of the conventional breeding colony from which the animals were derived is given and hysterotomy and hand-rearing techniques are described. | 1977 | 402500 |
| behavioural analysis of unilateral monoamine depletion in the marmoset. | unilateral stereotaxic injections of 6-hydroxydopamine (6-ohda) into the nigrostriatal bundle of marmosets (callithrix jacchus) produced substantial losses of tyrosine hydroxylase immunoreactive neurons from the substantia nigra, and mean dopamine (da) depletions of 98-99% in the caudate nucleus, putamen and nucleus accumbens, and of 91-97% in frontal cortex, on the side of the lesion. noradrenaline (na) and 5-hydroxytryptamine (5-ht) levels were also affected. behavioural tests conducted pre-op ... | 1992 | 1352726 |
| chronic mptp treatment reduces substance p and met-enkephalin content in the basal ganglia of the marmoset. | common marmosets were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp, 1.25-2.5 mg/kg s.c., twice a week) for 5-10 consecutive months. the initial doses of mptp produced a severe parkinsonian syndrome but motor activity was partially recovered at the end of treatment. fifteen days or 6 months after the last mptp dose, monkeys were sacrificed. in addition to a strong decrease of dopamine in the striatum, there were significant reductions in substance p and met-enkephalin content i ... | 1992 | 1380867 |
| evidence that most of the radioimmunoassayable inhibin secreted by the corpus luteum of the common marmoset monkey is of a non-dimeric form. | although recent data for several species of primate, including human and marmoset, indicate that the corpus luteum secretes high levels of radioimmunoassayable inhibin, the nature of the immunoreactive (ir) inhibin detected has not been established. in this study, plasma ir-inhibin levels during the ovarian cycle of the marmoset (n = 12 animals) were measured by alpha-subunit-directed inhibin ria, and values were compared with those estimated by a recently developed two-site immunoradiometric as ... | 1992 | 1391341 |
| quantification and excretion profiles of pteridines in primate urine. | biopterin, 6-hydroxymethyl-pterin, isoxanthopterin, neopterin and, pterin were quantified in stress-free collected spontaneous morning urine samples from callithrix jacchus, saguinus fuscicollis, saguinus labiatus, saimiri sciureus, presbytis entellus, cercopithecus albogularis, cercocebus torquatus, macaca fascicularis, hylobates concolor, pongo pygmaeus, and gorilla gorilla. in most species, biopterin was the most frequent urinary pteridine followed by neopterin. sex differences in biopterin a ... | 1992 | 1404333 |
| stimulation of immunoreactive inhibin production by preimplantation embryos during early pregnancy in the marmoset monkey (callithrix jacchus). | the role of the embryo in promoting increased plasma concentrations of immunoreactive inhibin after conception in the marmoset monkey was determined by flushing embryos from the uterus between days 5 and 9 after ovulation (implantation commences on days 11-12). blood samples were taken from each animal (three times a week) after ovulation until the end of the luteal phase. plasma inhibin concentrations were measured using a radioimmunoassay based on antisera against a synthetic fragment of the a ... | 1992 | 1432971 |
| dietary fat modulation of left ventricular ejection fraction in the marmoset due to enhanced filling. | the aim was to investigate the influence of long term dietary fish oil consumption on cardiac function in a non-human primate, to elucidate further the basis of the apparently reduced cardiovascular disease mortality associated with its consumption in man. | 1992 | 1451164 |
| polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 4. effects of multiple-dose treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) on peripheral lymphocyte subpopulations of a non-human primate (callithrix jacchus). | non-human primates (callithrix jacchus) were treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) over a period of 30 weeks, and lymphocyte subpopulations of venous blood were monitored using monoclonal antibodies and flow cytometry (facscan). there was no clear-cut change in the total lymphocyte population during this study. in the first part of the study the new-world monkeys (marmosets) were treated for 24 weeks with a weekly dose of 0.3 ng tcdd/kg body wt. at the end of this treatment per ... | 1992 | 1514923 |
| behavioural effects of anxiogenic agents in the common marmoset. | the effects of the anxiogenic agents fg7142, caffeine, pentylenetetrazole, and amphetamine were assessed in two anxiety situations in the marmoset, first in an "anxiogenic" test based on the animal's response to a human observer standing in front of the home cage and second in a low-anxiety situation where animals behaviour was videotaped in the absence of the observer. in response to the human observer, the anxiolytic agent diazepam (0.1-2.5 mg/kg, sc) was shown to reduce the intensity of behav ... | 1992 | 1528937 |
| treatment with antioxidants does not prevent loss of dopamine in the striatum of mptp-treated common marmosets: preliminary observations. | administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to common marmosets causes a profound loss of dopamine and serotonin in the striatum. additional daily systemic treatment of monkeys with the antioxidants ascorbic acid (100 mg/kg) and alpha-tocopherol (2,350 mg/kg) prior to, during and following administration of mptp does not prevent the loss of dopamine and serotonin in the striatum, suggesting that these antioxidants are unable to protect dopaminergic neurones against neur ... | 1991 | 1905937 |
| immunohistochemical distribution of the collagen types iv, v, vi and glycoprotein laminin in the healthy rat, marmoset (callithrix jacchus) and human gingivae. | the purpose of this study was to demonstrate the localization of collagen types iv, v and vi as well as the glycoprotein laminin in biopsies of healthy rat, marmoset (callithrix jacchus) and human gingivae. the slices, after the use of indirect immunofluorescence (incubation with antibodies against these extracellular matrix components), showed the same distribution with the anti-type iv and laminin antibodies on the basement membranes of the epithelium, blood vessels and nerves. collagen type v ... | 1991 | 1906570 |
| immunohistochemical localization of collagenous components in healthy periodontal tissues of the rat and marmoset (callithrix jacchus). i. distribution of collagen types i and iii. | the distribution of collagen types i and iii was demonstrated in healthy periodontal tissues of the rat and marmoset using immunofluorescent localization after decalcification of the maxillae and mandiblae in 0.2 n hcl. an intense fluorescence in the alveolar bone and cementum matrix, as well as in the soft periodontal tissue, was demonstrated with anti-collagen type i antibodies. in the gingival connective tissue and in the periodontal ligament thick fibers of collagen type i could be observed. ... | 1992 | 1532200 |
| [the significance of pcdd's/pcdf's (dioxins) in pediatrics]. | no epidemiological data are available up to now which reveal adverse effects induced by dioxins during an exposure through breast milk. furthermore, very few data on the concentration of pcdds/pcdfs in the newborn and during the first year of life have been published. of all pcdds/pcdfs, the substance with the highest toxicity is 2,3,7,8-tetrachlorodibenzo-p-dioxin. however, in the environment this congener is often only a minor component. a sensitive biological effect triggered by tcdd is the e ... | 1991 | 1961212 |
| the polymorphic photopigments of the marmoset: spectral tuning and genetic basis. | the marmoset (callithrix jacchus jacchus), a south american monkey, is polymorphic for the middle- to long-wave cone photopigments: the three variant pigments have spectral peaks at 543, 556 and 563 nm. comparisons of the deduced amino acid sequences of these pigments indicate that the variations in spectral sensitivity are associated with the presence or absence of hydroxyl-bearing residues at sites 180 and 285; but, in contrast to the additive hypothesis of neitz et al. (1991), we propose that ... | 1992 | 1534748 |
| corpus callosum in sexually dimorphic and nondimorphic primates. | the midsagittal area and other morphological measures were taken on the corpus callosum of four different species of primate: macaca mulatta, m. fascicularis, callithrix jacchus, and saguinus oedipus. the first two species are strongly dimorphic, whereas the new world forms show little dimorphism with regard to overall body size, canines, and brain weight. neither total corpus callosal area (totalcc), or other parts of the corpus callosum (cc) showed any significant sexual dimorphism in any of t ... | 1992 | 1562061 |
| analysis of the contraceptive potential of antibodies against native and deglycosylated porcine zp3 in vivo and in vitro. | we have undertaken a comparative analysis of the contraceptive activity of antibodies directed against the porcine sperm receptor zona pellucida antigen (zp3) and its mr = 32,000 polypeptide core (dgzp-32). the strategies employed for this analysis included the induction of active immunity in a primate, the common marmoset, and an in vitro fertilization protocol involving the use of viable human ova. in both experimental situations, antibodies against zp3 were shown to exhibit contraceptive acti ... | 1992 | 1576251 |
| dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey. | programmed electrical stimulation was used to examine the ability of long-term dietary lipid modulation to influence myocardial vulnerability to the induction of ventricular fibrillation in adult marmoset monkeys (callithrix jacchus). marmosets fed diets supplemented (to a total of 28.5% of the energy as fat) with polyunsaturated fatty acid (pufa)-rich tuna fish oil or sunflower seed oil had significantly elevated mean ventricular fibrillation threshold compared with those fed a saturated animal ... | 1992 | 1595535 |
| the relationship between cone pigments and behavioural sensitivity in a new world monkey (callithrix jacchus jacchus). | microspectrophotometric measurements of visual pigments and behavioural measurements of spectral sensitivity are reported for individual marmosets from 3 family groups. the sex differences and polymorphism that characterise the long-wave cone pigments in this species are well reflected by variations in the behavioural sensitivities. with one exception, the pattern of inheritance is compatible with a genetic model in which the long-wave pigment is specified by a single polymorphic locus on the x- ... | 1992 | 1604855 |
| an enkephalin degrading aminopeptidase of human brain preserved during the vertebrate phylogeny. | 1. a soluble human brain aminopeptidase which hydrolyses the tyr-gly bond of met-enkephalin and leu-enkephalin was identified in the brains of the following vertebrates: mammals (callithrix jacchus and rattus norvegicus), bird (gallus domesticus), reptile (tupinambis teguixin), amphibia (bufo paracnemis), fish (sarotherdon niloticus) and elasmobranchy (galeocerdo cuvieri). 2. the properties of this enzyme are: molecular weight near 100,000 da, isoelectric point near 4.9, optimum ph near 7.5, act ... | 1991 | 1685408 |
| immunoregulation in the common marmoset, calithrix jaccus: functional properties of t and b lymphocytes and their response to human interleukins 2 and 4. | non-human primates have been used to study immune function to a much lesser extent than readily available strains of inbred rodents. nevertheless, in situations where it might be desirable, but impossible, to study human immune responses in vivo, lower primates could provide an acceptable alternative. in order to extent the knowledge of t- and b-lymphocyte function in lower primates, the common marmoset callithrix jaccus was used as an experimental model. the functional similarities between this ... | 1990 | 2110549 |
| plasma vitamins a and e and hydrogen peroxide-induced in vitro erythrocyte haemolysis in common marmosets (callithrix jacchus). | plasma total lipid, cholesterol, all-trans retinol (vitamin a) and alpha-tocopherol (vitamin e) concentrations, and the susceptibility of erythrocytes to hydrogen peroxide-induced haemolysis in vitro were investigated in healthy laboratory-bred common marmosets (callithrix jacchus). the concentrations of alpha-tocopherol and total cholesterol were similar to those of control human subjects. the mean lipid concentration was higher (p less than 0.025) and the retinol concentration lower (p less th ... | 1990 | 2111954 |
| neurochemical and behavioural features induced by chronic low dose treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) in the common marmoset: implications for parkinson's disease? | protracted long-term treatment of common marmosets with 15 doses (0.5-4.5 mg/kg, i.p.) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp; total dose 25 mg/kg, given over 29 days) caused transitory changes in motor behaviour reminiscent of human parkinson's disease. 16 days from the start of mptp administration, all animals showed motor impairment, consisting of profound akinesia and a rigid posture, but in no case resting tremor. biogenic amines were measured in nigrostriatal regions one mon ... | 1991 | 1712088 |
| topographical and topological organization of the thalamocortical projection to the striate and prestriate cortex in the marmoset (callithrix jacchus). | in eleven hemispheres of nine marmoset monkeys (callithrix jacchus), we have investigated the thalamo-cortical organization of the projections from the pulvinar to the striate and prestriate cortex. in each experiment, single or multiple injections of various retrograde fluorescent tracers were injected into adjacent regions or areas. in two experiments, horseradish peroxidase (hrp) was injected into the lateral geniculate nucleus (lgn) and the lateral pulvinar, respectively. the results show th ... | 1991 | 1712314 |
| immunohistochemical localization of collagenous components in healthy periodontal tissues of the rat and marmoset (callithrix jacchus). ii. distribution of collagen types iv, v and vi. | the immunohistochemical distribution of collagen types iv, v and vi has been demonstrated in healthy periodontal tissues of rats and marmosets following decalcification of the maxillae and mandibulae in 0.2 n hcl. an intense fluorescence with anti-collagen type iv antibodies was demonstrated in the basement membranes of the epithelium and of the blood vessels and nerves. in the alveolar bone stroma and in the periodontal ligament (pl) collagen type iv was present only in the basal membranes of t ... | 1991 | 1714953 |
| distribution and morphology of substance p-immunoreactive structures in the olfactory bulb and olfactory peduncle of the common marmoset (callithrix jacchus), a primate species. | the present study describes the morphology and distribution of substance p-immunoreactive (sp-ir) elements in the olfactory bulb (ob) and olfactory peduncle (op) of the common marmoset (callithrix jacchus), a primate species. sp-ir neurons are very abundant in the ob and belong to two types. external tufted cells are present in the glomerular layer (gl), whereas granule cells are found in the deeper layers, especially in the granule cell layer (grl), but also scattered in the op. sp-ir fibers, p ... | 1991 | 1724304 |
| mr 40,000 human colonic epithelial protein expression in colonic mucosa and presence of circulating anti-mr 40,000 antibodies in cotton top tamarins with spontaneous colitis. | saguinus oedipus, callithrix jacchus, and saguinus fuscicollis are three species of new world monkeys which develop a form of colitis that is similar to human ulcerative colitis. only s oedipus, however, develop colon cancer. we examined intestinal tissues from these animals for the presence of an antigen cross reacting to the mr 40,000 human colonic epithelial protein that acts as an autoantigen in ulcerative colitis. using an anti-mr 40,000 monoclonal antibody (7e12h12, igm isotype), by an imm ... | 1992 | 1740277 |
| an evaluation of two animal models for dietary influences on reproductive toxicology. | chronic protein deficiency (8 weeks) was examined in marmosets (callithrix jacchus) and sub-acute (1 week) methionine- and choline-deprivation was investigated in f344 rats. the marmosets were considered to have become protein-deficient but there was no alteration in sperm morphology, either at the end of the diet or 5 weeks later. weight loss was also observed in rats on the methionine- and choline-free diet and they had significantly decreased sperm counts 4 weeks after the end of treatment. h ... | 1991 | 1768785 |
| de novo biosynthesis and localization of inhibin in marmoset (callithrix jacchus) and rat epididymis. | using specific polyclonal antibodies generated against a 13 kd human testicular inhibin, immunocytochemical localization was carried out in epididymis of intact and castrated marmoset monkey and rat epididymis. inhibin was found to be present in the cytoplasm of epithelial cells of caput, corpus and cauda epididymis. the intensity of staining and pattern of distribution did not change following castration. further, the in vitro biosynthesis of inhibin studied by incorporating 3h-leucine and prec ... | 1991 | 1769713 |
| [wound healing of the cornea of new world monkeys after surface keratectomy: er:yag-excimer laser]. | corneal wound healing was studied after photoablation with an excimer laser (193 nm, 43 pulses at 180 mj/cm2 [symbol: see text] 11 microns ablation depth, optical zone 2.0 mm) and with an erbium-yag laser (2.94 microns, 5 pulses at 2.5 j/cm2 [symbol: see text] 50 microns ablation depth, optical zone 1.6 mm). the corneas of marmosets (callithrix jacchus) were prepared 5 and 10 days and 4 and 25 weeks after photoablation. the sections were investigated by conventional light microscopy or exposed t ... | 1991 | 1786926 |
| ontogeny of monooxygenase activities in the marmoset monkey (callithrix jacchus). | the pre- and postnatal development of monooxygenases in the liver and adrenal gland of marmoset monkeys (callithrix jacchus) was investigated. cytochrome p450 was detected in the fetal adrenal gland, but aldrin epoxidase, ethoxycoumarin o-deethylase, and ethoxyresorufin o-deethylase activities were below detection limits. although fetal hepatic cytochrome p450 was not detected, low activities of aldrin epoxidase and ethoxycoumarin o-deethylase, but no ethoxyresorufin o-deethylase, could be detec ... | 1991 | 1787526 |
| monoclonal antibodies from epstein-barr virus-transformed lymphocytes of common marmosets (callithrix jacchus) immune to malaria. | the b lymphocytes of the common marmoset callithrix jacchus can be immortalized by infection with epstein-barr virus (ebv) in vitro (desgranges et al., 1976). c. jacchus is susceptible to infection with the blood stages of several species of malaria parasite including the line designated mvf1 (mitchell et al., 1988) from which it recovers and shows immunity to reinfection. by exploiting these two phenomena, ebv-transformed, marmoset lymphoblastoid cell lines secreting antibodies to malaria paras ... | 1990 | 2155967 |
| lipoprotein(a) and apolipoprotein(a) in a new world monkey, the common marmoset (callithrix jacchus). association of variable plasma lipoprotein(a) levels with a single apolipoprotein(a) isoform. | in an earlier report (chapman et al, biochemistry 1979;18:5096-5108), we suggested that the common marmoset may represent an important model for the study of human plasma lipoprotein metabolism. we now extend the interest of this monkey model to the study of lipoprotein(a) (lp[a]) and apolipoprotein(a) (apo[a]). density gradient ultracentrifugal fractionation of marmoset plasma revealed a bimodal distribution of lp(a), with one peak of concentration occurring in association with very low density ... | 1991 | 1829630 |
| synergism of the ampa-antagonist nbqx and the nmda-antagonist cpp with l-dopa in models of parkinson's disease. | degeneration of dopaminergic nigrostriatal neurons in parkinson's disease results in an overactivity of excitatory glutamatergic projections from the subthalamic nucleus to the output nuclei of the basal ganglia resulting in rigidity and akinesia. in theory pharmacological blockade of these overactive systems should improve parkinsonian symptomatology. the selective ampa-antagonist nbqx and the competitive nmda-antagonist cpp are not effective in animal models of parkinson's disease when given a ... | 1991 | 1835581 |
| morphological and histochemical effects of 2,3,7,8-tetrachlorodibenzo-p dioxin (tcdd) on marmoset (callithrix jacchus) testes. | the testes of marmosets (callithrix jacchus), which had been treated with a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) (0.3 microgram to 10 micrograms/l kg body weight (bw)) were studied after 7 days using morphological and histochemical techniques. light microscopic and electron microscopic examination revealed decreased intercellular contact in the germinal epithelium, as indicated first by enlarged intercellular spaces between the sertoli's cells and between the sertoli's cells ... | 1991 | 1872647 |
| relative effects of activin and inhibin on steroid hormone synthesis in primate granulosa cells. | ovarian granulosa cells produce inhibin and activin, structurally related proteins with potentials to directly modulate follicular steroidogenesis. the aim of the present study was to compare development-related effects of inhibin-a and activin-a on steroidogenesis in marmoset monkey (callithrix jacchus) granulosa cells. granulosa cells from "immature" (< 1.0 mm diameter) and "mature" (> 2 mm diameter) follicles were incubated in serum-free culture medium for 96 h with and without peptide (1-100 ... | 1992 | 1464664 |
| synergism of nbqx with dopamine agonists in the 6-ohda rat model of parkinson's disease. | advance in understanding of the anatomy, physiology and pharmacology of basal ganglia organisation over the past decade revealed a functional relation between excitatory glutamatergic and the degenerated dopaminergic nigrostriatal transmitter systems which could serve as targets for pharmacological interventions in parkinson's disease. the selective ampa-antagonist nbqx is not effective in animal models of parkinson's disease when given alone but ameliorates parkinsonian symptomatology and enhan ... | 1992 | 1491248 |
| polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 2. in vitro effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) on lymphocytes of venous blood from man and a non-human primate (callithrix jacchus). | the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) on poke weed mitogen-stimulated proliferation and differentiation of peripheral lymphocytes was studied in vitro with cells from a non-human primate (marmoset monkey, callithrix jacchus) and from man. monoclonal antibodies and flow cytometry (facscan) were used for analysis. the extent of the overall mitogen-stimulated proliferation of isolated lymphocytes in vitro from marmoset blood was only slightly reduced in the presence of tcdd compa ... | 1991 | 1905127 |
| co2 breath tests using 14c-caffeine, 14c-methacetin and 14c-phenacetin for assessing postnatal development of monooxygenase activities in rats and marmosets. | the time course in which the activities of cytochrome p450-dependent drug-metabolizing enzymes develop during the perinatal period differs for various types of monooxygenases as well as for various animal species. using [3-methyl14c]-, [7-methyl14c]-caffeine, [14ch3]-methacetin and [14c2h5]-phenacetin as substrates in breath tests, the developmental changes in the rates of 14co2 formation, due to changes in the activity of monooxygenases, were studied in rats and marmoset monkeys (callithrix jac ... | 1991 | 1914790 |
| [3h]harman binding experiments. ii: regional and subcellular distribution of specific [3h]harman binding and monoamine oxidase subtypes a and b activity in marmoset and rat. | [3h]harman (1-[3h]methyl-beta-carboline) was used in a novel radioligand binding assay to label selectively and with high affinity monoamine oxidase (mao) type a. the concentration of the enzyme was determined in six cns regions of the primate species marmoset (callithrix jacchus) and of the rat: hypothalamus, hippocampus, cerebellum, cerebral cortex, striatum, and spinal cord. the specific [3h]harman binding in the cns of the marmoset reveals the same pharmacological profile and other character ... | 1991 | 1988553 |
| [yersinia pseudotuberculosis in new world monkeys]. | it is reported on four cases of pseudotuberculosis in 2 saimiri sciureus, 1 callithrix jacchus/penicillata hybrid and 1 s. oedipus. the animals came from two different groups, one being infected with y. pseudotuberculosis serotype i, the other with y. pseudotuberculosis serotype ii. all cases showed intestinal infection of thermophile campylobacter. remarkable were severe haemorrhagic components and the distinct rhs-proliferation, especially in the mesenteric lymphatic nodes. | 1991 | 2015031 |
| synthesis of human renin inhibitory peptides, angiotensinogen transition-state analogs containing a retro-inverso amide bond. | the experimental details for the synthesis of human renin inhibitors are described. in order to avoid metabolic degradation of the phe-his (p3-p2) amide bond in transition-state analogs, structurally modified acyl residues (p4-p3) were incorporated into the inhibitors. compound 1a, which contained 2-(1-naphthylmethyl)-3-(n-phenethylcarbamoyl)propionyl residue (p4-p3) with a retro-inverso amide bond, l-histidine, and norstatine isoamylamide residue (p1-p1) as a transition-state mimic, had potent ... | 1990 | 2085885 |
| evaluation of the toxicity of indomethacin in a 4-week study, by oral route, in the marmoset (callithrix jacchus). | a subacute toxicity study of indomethacin administered by oral route, was carried out in the marmoset (callithrix jacchus). groups of three males and three females received indomethacin directly into the stomach by means of a catheter for a period of 4 weeks at the dose levels of 0, 2, 6, and 12 mg/kg body wt/day and then were euthanized for pathological evaluation. all marmosets given 12 mg/kg/day and one marmoset given 6 mg/kg/day died during the dosing period (within 20 days). at 12 mg/kg/day ... | 1990 | 2086319 |
| lack of change in striatal darpp-32 levels following nigrostriatal dopaminergic lesions in animals and in parkinsonian syndromes in man. | the present study was performed to determine the effect of a nearly complete nigrostriatal dopaminergic denervation on darpp-32 levels in the striatum from animals and parkinsonian patients. darpp-32 levels were estimated by in vitro phosphorylation in the presence of camp, or after inactivation of endogenous kinases and phosphatases, in the presence of the catalytic subunit of camp-dependent protein kinase. intranigral 6-hydroxydopamine (6-ohda) infusion in rats, or peripheral administration of ... | 1990 | 2105823 |
| genetically distinct cell populations in naturally occurring bone marrow-chimeric primates express similar mhc class i gene products. | the cotton-top tamarin (saguinus oedipus) is a naturally occurring "a" + "b"----"a" bone marrow-chimeric species. these primates usually are born as dizygotic twins and, due to placental vascular anastomoses, develop sharing each others' bone marrow elements. strikingly, almost 50% of the pbl of a member of a twin pair are derived from the hematopoietic stem cells of its cotwin. to clarify the mechanisms underlying the maintenance of tolerance in these stable chimeras, mhc gene products have bee ... | 1990 | 2110210 |
| isolation and characterization of several plasma apolipoproteins of common marmoset monkey. | to explore the potential of the common marmoset monkey (callithrix jacchus) as a model for human plasma lipoprotein metabolism, several marmoset apolipoproteins were isolated and characterized in this study. based on several properties, including molecular weight, amino acid composition, and sequence, the marmoset apolipoproteins are strikingly similar to human apolipoprotein (apo) a-i, a-ii, c-iii, and a-iv. the first 54 residues of marmoset apo a-i showed 87% sequence identity with the corresp ... | 1990 | 2114867 |
| isolation and characterization of plasma lipoproteins of common marmoset monkey. comparison of effects of control and atherogenic diets. | this study examines the potential of the common marmoset monkey (callithrix jacchus) to serve as a model for human lipoprotein metabolism and atherosclerosis. the lipoproteins of animals fed a low-fat, low-cholesterol diet and a high-fat (12% wt/wt lard), high-cholesterol (0.34% wt/wt) diet were characterized by the combination of sequential ultracentrifugation and pevikon block electrophoresis. based on chemical and physical properties, equivalents of human very low density lipoproteins (vldl), ... | 1990 | 2114868 |
| distribution of two morphologically distinct subsets of serotoninergic axons in the cerebral cortex of the marmoset. | the serotoninergic innervation of the marmoset (new world monkey, callithrix jacchus) cerebral cortex has been analyzed by using immunocytochemistry. the use of a sensitive monoclonal antibody against serotonin allowed the visualization of the fine morphology of individual axons. two types of terminal axons were demonstrated: one has sparse, small, ovoid varicosities (dia. less than 1 micron), and the other has large, spheroidal varicosities (up to 5 microns in dia.), which are more densely clus ... | 1990 | 2115053 |
| ofloxacin in juvenile non-human primates and rats. arthropathia and drug plasma concentrations. | arthropathia in juvenile animals is the most important toxic effect induced by quinolones. we conducted pharmacokinetic and morphological studies with ofloxacin on non-human primates (callithrix jacchus, marmosets) and rats. in the marmoset, electron microscopy and the application of immuno-morphological methods proved to be suitable for the detection of specific alterations in cartilage (e.g. loss of proteoglycans and altered chondrocytes). subsequently performed electron microscopic examinatio ... | 1990 | 2115323 |
| suppression of bioactive luteinizing hormone and testosterone by a progesterone antagonist zk 98.734 in adult male common marmosets, callithrix jacchus. | the effects of a progesterone antagonist zk 98.734 on release of bioactive luteinizing hormone (lh) and testosterone were studied in adult male common marmosets by using the following experimental protocols: (1) the blocking of the nocturnal rise in testosterone levels by zk 98.734, (2) the pharmacodynamic effects of zk 98.734 on testosterone and lh levels, (3) the reversal of zk 98.734-induced decrease in testosterone by treatment with human chorionic gonadotropin (hcg), and (4) the blocking of ... | 1990 | 2116922 |
| 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-methyl-mptp) is less neurotoxic than mptp in the common marmoset. | four adult marmosets were treated with increasing doses of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-methyl-mptp) in the range 0.23-4.3 mg/kg i.p. to give a cumulative dose of 11.0-11.6 mg/kg over a 6-10 day period. after 4 days of treatment, and as the dosage was gradually increased, the animals exhibited mild motor deficits. these abnormalities slowly declined over the following 1-6 week period. in contrast, similar treatment of common marmosets with 1-methyl-4-phenyl-1,2,3,6 ... | 1990 | 2117541 |
| inoculation of new world primates with the human immunodeficiency virus. | the susceptibility of common marmosets and cotton-top tamarins to infection by hiv-2 in vivo was tested. one year and 19 months, respectively, post-inoculation, sera taken from three of four animals from each species are reactive for hiv-2 antibodies and hiv-specific nucleotide sequences were demonstrated in short-term cultures of pbl from two cotton-top tamarins. the animals remain in good health. | 1989 | 2503618 |
| n-3 and n-6 phosphoglyceride fatty acids in relation to in vitro erythrocyte haemolysis induced by hydrogen peroxide in captive common marmosets (callithrix jacchus). | 1. hydrogen peroxide-induced haemolysis (hpih) was studied in the red blood cells of the common marmoset monkey (callithrix jacchus) in relation to the composition of the membrane fatty acids. hpih (%) was surprisingly high (mean 41% +/- 34; median 33.4%) and significantly different (p less than 0.001) from the corresponding value in healthy human subjects (mean 0.98% +/- 0.6; median 1.3%). 2. it was negatively correlated with 18:2n-6 (r = -0.76, p less than 0.001), 18:2n-6/20:4n-6 (r = -0.70, p ... | 1990 | 2123763 |
| persistence of various polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdds and pcdfs) in hepatic and adipose tissue of marmoset monkeys. | a defined mixture of polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdds and pcdfs) was subcutaneously administered to marmoset monkeys (callithrix jacchus). tissue concentrations in hepatic and adipose tissue were measured at different times after treatment (1-28 weeks). one week after application high concentrations could be detected for the 2,3,7,8-substituted congeners only. the percent of the administered dose in whole liver differed for the various 2,3,7,8-substituted congeners, ran ... | 1990 | 2125825 |
| transfer of various polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdds and pcdfs) via placenta and through milk in a marmoset monkey. | a defined mixture of polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdds and pcdfs) was subcutaneously administered to a pregnant marmoset monkey (callithrix jacchus) 11 weeks prior to delivery. transfer of pcdds and pcdfs via placenta and mother's milk was investigated by measurement of concentrations in a newborn 1 day after birth and in an infant of the same litter after a lactation period of 33 days. furthermore, comparative measurements were performed in different tissues of the moth ... | 1990 | 2128593 |
| inhibin secretion during the ovulatory cycle and pregnancy in the common marmoset monkey. | changes in plasma concentrations of immunoreactive inhibin in the reproductively cyclic, pregnant and ovariectomized female marmoset monkey (callithrix jacchus) were measured with a heterologous radioimmunoassay. the pattern of inhibin secretion in five marmosets studied individually during four consecutive cycles was shown to resemble that of progesterone. in these animals, data were pooled according to stage of cycle on the basis of plasma progesterone concentrations. mean values for inhibin w ... | 1990 | 2212937 |
| extension of reproductive suppression by pheromonal cues in subordinate female marmoset monkeys, callithrix jacchus. | pheromonal signals from the dominant female marmoset monkey were implicated in maintaining the suppression of lh secretion and ovulation in socially subordinate females. when subordinate, and reproductively suppressed, female marmoset monkeys were removed from their group without scent contact with their dominant females, subordinate females in control group 1 (n = 8) and control group 2 (n = 5), ovulated 10.8 +/- 1.4 days and 10.4 +/- 0.8 days respectively (mean +/- s.e.m.) after separation. su ... | 1990 | 2250240 |
| studies on the ascorbic acid metabolism of callitrichid monkeys by 14c isotope excretion technique. | recently it has been found that the two monkey species callithrix jacchus and saguinus fuscicollis, both belonging to the same new world monkey family callitrichidae and held in the same colony under identical conditions, had extremely different serum ascorbate levels. to examine the ascorbic acid metabolism the 14c-excretion of orally given 1-14c-ascorbic acid was studied under conditions of marginal and abundant vitamin c supply and under intentional stress. there were large differences in the ... | 1990 | 2251861 |
| [radiotelemetric studies of the body temperature of white-tufted monkeys (callithrix jacchus)]. | a newly developed telemetry system was used to study deep body temperature (bt) of two adult male common marmosets (callithrix jacchus). the bt-curves of both monkeys showed a similar clear circadian rhythm with a range up to 3.5 degrees c. at environmental temperature of 28 degrees c (et) the bt of the monkeys varied in the daytime dependent on their spontaneous activity, with little individual differences between 37.5 degrees c and 39.3 degrees c; at night the bt of the remarkably deeply-sleep ... | 1990 | 2251862 |