| neuropathology of "spinning syndrome" induced by prenatal intoxication with a pcb in mice. | a striking motor dysfunction, "spinning syndrome," developed with a high frequency in weaning mice whose dams received oral 3,4,3',4'-tetrachlorobiphenyl (4-cb) during gestation (day 10 through day 16). the syndrome is permanent and is characterized by swift circling movements sustained in one direction at a minimal rate of 40 turns/min (usually 50 to 150 turns/min), restlessness, and hyperkinesia. twenty-four spinners and 4-cb nonspinners and age-matched controls were subjected to histopatholog ... | 1979 | 110196 |
| comparison of three techniques for the detection of antibodies to double-stranded dna: immunofluorescence on trypanosoma gambiense, immunofluorescence on crithidia luciliae and radioimmunoassay using the farr technique. | three techniques for the detection of antibodies against double-stranded dna were compared: two immunofluorescent (if) techniques using either trypanosoma gambiense or crithidia luciliae as antigen and a radioimmunoassay (ria) based on the farr technique. the if on t. gambiense or c. luciliae gives very similar results but the reaction on c. luciliae is easier to read and to interpret. the use of c. luciliae permits the swift elimination of the two main causes of errors: antibodies against the n ... | 1978 | 358907 |
| the adaptive increase in ethanol metabolism due to pretreatment with ethanol: a rapid phenomenon. | simple models were developed to study changes in oxygen uptake in perfused rat liver and increases in ethanol metabolism in vivo. results obtained 2.5 hours following a large dose of ethanol were quantitatively similar to those seen after 24 hours or 5 weeks. the rapidity of the increase indicated that siam represents an activation rather than an adaptation. pathways responsible for the swift increase in alcohol metabolism (siam) in the perfused rat liver were investigated through the use of oua ... | 1979 | 510161 |
| the swift increase in alcohol metabolism: comparative studies with other alcohols. | | 1979 | 552310 |
| [the cardiovascular response to gradual increase of intracranial pressure in experiments on animals (author's transl)]. | experiments were performed on dogs to examine the cardiovascular response (cushing' reflex) to slow increase of intracranial pressure (icp) by means of an epidural balloon. in contrast to the acute increase in icp, a slow but constant increase of the cardiac output (co) was observed, followed later by a short and steep increase of blood pressure, in various experiments with different icp. in the range of icp from 30 to 100 mm hg a linear relation existed between the icp and co. the experiments i ... | 1978 | 637287 |
| a potential artifact in use of a new technique for rapid brain removal. | new techniques are are continuously being developed to obtain animal brain tissue that is as close as possible to its in vivo status. the brain-blowing technique provides a swift freezing of brain tissue (within 1 s) in which postmortem changes have been said to be minimal. higher concentrations of glucose were present in brain samples removed by this method than have previously been found when the brain was frozen in situ, but at the same time the plasma levels of glucose were higher. it is sug ... | 1978 | 645851 |
| [swift preparation of hemoglobin free ghosts of human red cells (author's transl)]. | ghosts are adsorbed on extemporaneously formed tricalcium phosphate precipitate in lytic medium. they are free of hemoglobin and chemical characteristics are in good agreement with those obtained by dodge (3) and hanahan (5). | 1976 | 772564 |
| [epidemiological and bacteriological study on the outbreak of gastroenteritis due to escherichia coli 0111:b4 which occured in hospital environment]. | the authors report the results of the bacteriological researches carried out during an outbreak of gastroenteritis from e. coli o111:b4 having concerned, in 6 months, 40 infants of the pediatric ward at legnano's hospital. the researches clearly demonstrate the need for a strict control, particularly in the pediatric and neonatal wards, so as to make possible a swift identification of the gastroenteric syndromes due to e. coli strains which cause enteritis. the gravity of the symptomatology, the ... | 1975 | 779670 |
| renal prostaglandin synthesis in the spontaneously hypertensive rat. | the precise role of the kidney in spontaneous experimental hypertension is unknown. we have analyzed the rates of renal prostaglandin synthesis by utilizing a spontaneously hypertensive rat model. the synthetic rate of prostaglandin e2, prostaglandin f2alpha, and prostaglandin a2-like products was measured in vitro with renal microsomes. in the rabbit and rat there is a steep gradient of microsomal prostaglandin synthetase from papilla to cortex with highest activities in the papilla. comparison ... | 1976 | 823178 |
| [differentation and timeinterval for detection of tissue cells on a weapon used in a crime (author's transl)]. | there are numerous methods of examining the weapon used in a crime to detect evidence of blood or of blood-group properties. forensic literature also contains references to the tracing of organic tissue. in the case against jaccoud the two medical experts called upon, undritz and hegg, found evidence of cells from internal organs on a knife which had possibly been used to commit the crime and which had been stored away for some considerable time. practical experience has shown that the likeliho ... | 1976 | 961064 |
| kidney cooling in partial nephrectomy. evaluation of a technique. | a technique of cooling the isolated human kidney by immersing it in a plastic bag filled with iced saline slush is described. this technique is simple, swift to perform, requires no specialized equipment, and is inexpensive; it has proved to be effective and safe. | 1975 | 1093302 |
| a light- and electron-microscope study of the oocyte nucleus during development of the antral follicle in the prepubertal mouse. | the ordered changes which occur in the structural organization of the mouse oocyte nucelus during the preparatory, the maturative and the preovulatory stages of antral follicle development, have been studied under both light and electron microscopy. all observations have been made on those antral follicles whose development is initiated on postnatal day 14 and completed by postnatal day 28 in prepubertal animals of the icr albino mouse strain. the formed entities that can be recognized within th ... | 1975 | 1141388 |
| high speed cinemicrographic studies on rabbit tracheal (ciliated) epithelia: determination of the beat pattern of tracheal cilia. | high speed cinemicrographs reveal that the ciliary configuration and beat pattern of rabbit tracheal cilia differ significantly from classid descriptions, although the basic forward and return pattern is still observed. the tracheal cilia are short and stout (about 6 mum in length) and are of a slightly bent original configuration bent original configuration. at the start of the forward stroke, the cilia bear about 75-90 degrees to the epithelial surface in the direction of the forward stroke. t ... | 1976 | 1246470 |
| control of rnase e-mediated rna degradation by 5'-terminal base pairing in e. coli. | despite the variety of messenger rna half-lives in bacteria (0.5-30 min in escherichia coli) and their importance in controlling gene expression, their molecular basis remains obscure. the lifetime of an entire mrna molecule can be determined by features near its 5' end, but no 5' exoribonuclease has been identified in any prokaryotic organism. a mutation that inactivates e. coli rnase e also increases the average lifetime of bulk e. coli mrna and of many individual messages, suggesting that cle ... | 1992 | 1280335 |
| [kinetics of vaccination antibodies against tetanus toxoid, diphtheria toxoid, measles virus, poliomyelitis virus and pneumococcus after allogenic and autologous bone marrow transplantation and booster vaccination. 2: kinetics of vaccination antibodies against diphtheria toxoid after allogenic and autologous bone marrow transplantation]. | in the second part of the paper we report on the results of the diphtheria antitoxin valuation of 8 children after allogeneic bone marrow transplantation (bmt) with and without graft versus host disease (gvhd) as well as on the kinetics of the diphtheria antitoxin of 5 children after allogeneic bmt with and without gvhd and of 5 children after autologous transplantation. the antibody valuation was done by a cell-culture assay. whereas the inspection of the isolated data gives the impression of a ... | 1992 | 1434337 |
| novel coagglutination method for serotyping group b streptococci. | a group g streptococcal strain was coated with antibody against six different serotypes (ia, ib, ii, iii, iv, and v) of group b streptococci. the coagglutination patterns of 114 strains of group b streptococci were compared with the serotypes determined after immunoprecipitation. the specificity of the method was 100% and the sensitivity 97%. it was used for the typing of 89 invasive and 101 colonizing isolates. the new method is swift, specific, and highly sensitive. it consumes only minute amo ... | 1992 | 1452713 |
| [free alveolar cells in experimental pulmonary emphysema. i. statistical analysis of cellular composition and lung morphometry]. | the study was carried out on an experimental papain induced model of pulmonary emphysema. the authors assessed the cell populations sampled with lavage. special emphasis was directed on alveolar macrophages and neutrophils. extent of emphysema was analysed morphometrically. the authors demonstrated an influx of neutrophils 24 hours after papain was introduced intratracheally. this was followed by a swift decrease of the number of sampled neutrophils. seven days latter the neutrophil count return ... | 1992 | 1493504 |
| the exposure of carcinogen-initiated primary neonatal rat hepatocytes to tumor promoters modulates both the transcripts and the enzymatic activity of nuclear poly(adp-ribose) polymerase. | four tumor promoters, i.e. pb, tpa, naf, and ddt, added singly to a calcium-deprived synthetic medium, elicited early and late mitogenic effects and concurrent surges of nuclear poly(adp-ribose) polymerase (padprp) activity in primary neonatal rat hepatocytes mutagenized with an intra-uterine dose of dmn. these actions were fully abated by the padprp inhibitor 3-mba. conversely, egf only acted as a full mitogen when medium's calcium was at physiological levels, and its effects could not be block ... | 1992 | 1540155 |
| membrane bioreactors as hybrid artificial pancreas: experimental evaluation. | results of cultured islet transplantation in the management of insulin-dependent diabetes are still unsatisfactory. the main problem preventing success is the swift and resolute host immune rejection. to obviate this we designed and experimented a model of bioartificial pancreas, made of polymeric hollow fibers, put into the blood circulation as an artero-venous bypass to immunoisolate endocrine tissue from leucocytes and immunoglobulins. we tested four different membrane bioreactors (br1-4). br ... | 1992 | 1555877 |
| [initial clinical application of cardiac pacing needle for emergency cardiac pacing]. | this paper deal with the newly designed cardiac pacing needle which is used as an electrode in temporary cardiac pacing. animal experiment has shown that in emergency life-saving this needle was functional and reliable. this also has been identified by clinical application. by utilizing the needle, the authors have successfully saved three patients' life threatened by sudden death. using this needle to pace the heart is simple, swift, immediate and has less side effect. it is specially fit for g ... | 1992 | 1627945 |
| phlebotomy for erythropoietin-induced malignant hypertension. | four patients on regular dialysis treatment whose blood pressure was well controlled, developed malignant hypertension while receiving maintenance recombinant human erythropoietin (r-hu-epo). none of these patients had a haematocrit greater than 35% at any stage, and clinically, none had any evidence of fluid overload. initially, they were all managed by stopping r-hu-epo and intensification of antihypertensive therapy. however, none of the patients responded, and venesection of 500 ml of blood ... | 1992 | 1630548 |
| dendritic location of neural bc1 rna. | in nerve cells, a specialized protein synthetic machinery is thought to operate in local compartments of dendrites, in particular beneath synaptic junctions, and thereby to facilitate swift adjustments of the postsynaptic protein repertoire in situ. this notion has been supported by the identification of polyribosomes and selected mrnas in those compartments. in this study, we report the discovery of a specific rna polymerase iii transcript in dendrites. this rna, a noncoding, 152-nucleotide-lon ... | 1991 | 1706516 |
| molecular genetics--new horizons in haematology. | the unprecedentedly swift developments in molecular genetics has opened up a new era in biology and medicine. the powerful methods of recombinant dna (rdna) technology are fast moving into the fields of diagnostics and therapy since the newly found ability to define physiological and pathological cell functions at a molecular level. the centerpiece of molecular genetics is the possibility to map and determine the fine structure of human genes and to define in molecular terms how each gene contro ... | 1991 | 1726792 |
| [the era of molecular genetics. new perspectives in hematology]. | the unprecedently swift developments in molecular genetics opened up a new era in haematology. the regulation of the expression of globin genes and its coordination with the expression of genes coding for other red cell specific proteins, as well as molecular genetics of some intrinsic haemolytic anaemias and the clinically important recent results revealing the genetic regulation of iron metabolism are discussed. new unfolding concepts of the physiological regulation of the haemopoetic stem cel ... | 1992 | 1736227 |
| phasic and tonic responses of premotor and primary motor cortex neurons to torque changes. | responses to torque step perturbation of the wrist were compared in premotor area (pma) and motor cortex (mi) neurons of the monkey. a substantial portion (39%) of cells recorded from the pma had phasic responses with onset latencies as short as those found in mi (mostly between 15 and 50 ms). responsiveness to small perturbations, directional specificity and linear correlation of phasic responses with the velocity of displacement are properties that were essentially present in the pma. a role o ... | 1991 | 1756805 |
| comparison of protein tyrosine phosphorylation and morphological changes induced by il-2 and il-3. | we constructed cell lines which can proliferate in response to il-2 or il-3 by introducing a wild-type and mutant forms of cdnas encoding the human il-2r p75 chain into an il-3 dependent hematopoietic cell line which expresses the p55 chain of the il-2r. we compared early events that were induced in these cells by il-2 and il-3. analysis of protein tyrosine phosphorylation showed that two common protein bands, pp95 and pp90, were phosphorylated by stimulation of either il-2 or il-3, suggesting t ... | 1991 | 1760408 |
| history of clarke's stereotactic instrument. | the first original stereotactic instrument was designed by the turn of this century by the british surgeon, anatomist, and physiologist robert henry clarke. in 1905 james swift, in london, constructed the first machine, 'clarke's stereoscopic instrument employed for excitation and electrolysis'. it was first used in 1906 by clarke and victor horsley to create minute electrolytic lesions in the cns of animals. the stereotactic apparatus was patented by clarke in 1914 and cost 300 pounds. two furt ... | 1991 | 1819133 |
| [a case of accessory cardiac bronchus with acute empyema treated by open drainage]. | a 40-year-old man was admitted to the hospital because of acute empyema localized in the right lower posterior pleural space. the conservative treatment with antibiotics for one month failed to show any clinical improvement. surgical intervention, therefore, was required. broncho-fiberscopic and bronchographic findings prior to open drainage revealed a supernumerary bronchus with inflammatory sign on the right intermediate bronchus and a small sprig like bronchial fistula attached to the tip of ... | 1991 | 1886300 |
| acquired immunodeficiency syndrome with disseminated toxoplasmosis presenting as an acute pulmonary and gastrointestinal illness. | encephalitis due to the protozoan toxoplasma gondii has emerged as a common cause of central nervous system disease in patients with acquired immunodeficiency syndrome. extraneural disease is less common and more difficult to diagnose. we report a case of widely disseminated toxoplasmosis that presented as acute gastrointestinal and pulmonary disease in a patient without a prior diagnosis of acquired immunodeficiency syndrome. the diagnosis of toxoplasmosis was made only at autopsy. antemortem d ... | 1991 | 2021313 |
| intracellular transport and sorting of mutant human proinsulins that fail to form hexamers. | human proinsulin and insulin oligomerize to form dimers and hexamers. it has been suggested that the ability of prohormones to self associate and form aggregates may be responsible for the sorting process at the trans-golgi. to examine whether insulin oligomerization is required for proper sorting into regulated storage granules, we have constructed point mutations in human insulin b chain that have been previously shown to prevent formation of insulin hexamers (brange, j., u. ribel, j. f. hanse ... | 1991 | 2040652 |
| giant, human immunodeficiency virus-related ulcers in the esophagus. | human immunodeficiency virus (hiv) infection of the esophagus has recently been implicated as a cause of giant esophageal ulcers in hiv-positive patients with odynophagia. the authors examined four patients in whom esophagograms (one single-contrast and three double-contrast studies) revealed giant, hiv-related ulcers indistinguishable from those of cytomegalovirus (cmv) esophagitis. all four patients had severe odynophagia, one had an associated maculopapular rash, and two became hiv-positive a ... | 1991 | 2068293 |
| [prostaglandin levels in the lung tissue of guinea pigs with tuberculosis treated with antitubercular drugs and indomethacin]. | an experiment was carried out on 135 guinea-pigs (21 were used as controls and the rest subcutaneously infected with virulent m. tuberculosis culture. the latter were divided into 4 groups depending on the treatment regimen. the experiment was conducted for 3 months. the content of prostaglandins (pg) e and f2 alpha in the lung tissue was measured by radio-immunoassay. it was found that a spontaneous development of tuberculosis in the guinea-pigs was accompanied by phasic changes of pg. the peri ... | 1990 | 2080163 |
| disseminated tuberculosis of the central nervous system responsive to rifabutin. | multiple cerebral tuberculomas are now very rare. we report the case of a young man with an 8-month history of headache, febricula and abscess of the left tibiotarsal joint, which was found to contain mycobacterium tuberculosis. chest x-rays revealed miliariform dissemination to both lungs while ct and mr brain scans revealed numerous small nodules, especially in the posterior cranial fossa. despite anti-tuberculosis therapy the patient developed a right pyramidal hemisyndrome and intracranial h ... | 1990 | 2163369 |
| cutaneous zygomycosis in a diabetic htlv-i-seropositive man. | zygomycosis, an invasive fungal infection, is usually seen in persons with diabetes, particularly in those with diabetic ketoacidosis. the infection most frequently occurs in the rhinocerebral region and rapidly spreads, causing a swift demise. rarely, the infection is confined to the cutaneous tissues. we describe a 31-year-old man seropositive for human t lymphotropic virus type i who had diabetic ketoacidosis with zygomycosis confined to the right arm. the lesion was presumed initially to be ... | 1990 | 2335589 |
| is booster injection with hepatitis b vaccine necessary in healthy responders? a study of the immune response. | loss of protective anti-hbs levels (less than 10 iu/l) was noted in 5 (13%) of 38 well documented healthy responders to hepatitis b vaccine 30 months after completing the initial standard vaccination series. revaccination with a single booster injection of 20 micrograms hepatitis b vaccine intramuscularly resulted in anti-hbs levels well above those initially obtained, thus confirming considerable immunological memory. both decline prior to and rise after booster injection were proportional to t ... | 1989 | 2523924 |
| amino-acid sequences and functional differentiation of hemoglobins a and d from swift (apus apus, apodiformes). | the blood of the adult swift contains one major (hba = alpha 2a beta 2) and two minor components (hbd = alpha 2d beta 2 and hbd'). the components were separated by fplc with a tsk sp-5 pw-column in phosphate buffers, and were eluted with a linear nacl gradient. hbd' could be detected only in freshly prepared hemolysates with the sensitive fplc separation method. the globin chains were separated on a cation exchanger (cm-cellulose), the tryptic peptides by hplc with a rp-2 lichrosorb column. thei ... | 1989 | 2610936 |
| swift increase in alcohol metabolism in humans. | one hundred and fifteen human male subjects, 19-30 years of age, received ethanol orally as vodka (0.55, 0.7, or 0.85 g/kg) followed by a second drink (0.3-0.4 g/kg) given 3-4 hr later. after both doses, blood ethanol levels reached approximately 100 mg/dl. breath samples were taken every 20-30 min and rates of ethanol elimination were determined. in addition to the design described above, 100 subjects received 0.7 g/kg ethanol in two separate visits to the laboratory. in a third experimental de ... | 1989 | 2679213 |
| prevention and treatment of preterm labor. | premature delivery occurs in about 10 percent of pregnancies. the complications of prematurity account for two-thirds of all neonatal morbidity and mortality not caused by congenital defects. the key to managing preterm labor is early recognition of the condition and swift institution of appropriate measures to prevent delivery. treatment includes bed rest and therapy with tocolytic drugs, such as ritodrine, terbutaline and magnesium sulfate. educational programs aimed at high-risk patients can ... | 1989 | 2683688 |
| macrofilaricidal activity of metabolites of diethylcarbamazine. | the antifilarial compound diethylcarbamazine (n,n-diethyl-4-methyl-2-piperazine, dec) is known rather for its micro- than macrofilaricidal activity. but in some human filariasis i.e. loaiasis, lymphatic filariasis, the spectrum of dec activities extends to adult filaria. the potential role of the metabolites of dec in the action of the parent drug once it had been metabolized in the body of infected animals was investigated. the metabolites were evaluated in a new experimental model on which dec ... | 1989 | 2730692 |
| epidermal growth factor has both growth-promoting and growth-inhibiting effects on physical and neurobehavioral development of neonatal mice. | the protein molecule epidermal growth factor (egf) exerts powerful effects on mouse physical development, since repeated subcutaneous administrations of murine egf (3.5 mg/kg, from postnatal day 2 to postnatal day 10) cause precocious eyelid opening (as early as day 8 instead of day 13 in control littermates receiving 3.5 mg/kg cytochrome c) and precocious eruption of the lower incisors (day 6 instead of day 8). by contrast, the same egf treatment retards both the rate of body growth and the ful ... | 1989 | 2784706 |
| responses of neurons in the rat nucleus submedius to noxious and innocuous mechanical cutaneous stimulation. | extracellular recordings were used to characterize responses to cutaneous mechanical stimulation of 78 neurons in the rat nucleus submedius (sm). thirty-nine of these units were activated by some type of cutaneous mechanical stimulation. eighteen cells were activated exclusively by noxious stimuli. in 13 of these cells, responses were of swift onset and relatively rapid termination following stimulus application. in contrast, in three neurons responses were delayed both in onset and termination, ... | 1989 | 2816204 |
| a low copy number cosmid. | a low copy number cosmid was constructed by subcloning the pair of cos sites and the kanamycin resistance gene of pcos2embl into pgb2. the resulting cosmid, ppr691, has the psc101 replicon and specifies resistance to kanamycin, spectinomycin, and streptomycin. ppr691 also carries restriction sites suitable for cloning partial sau3a digests using the strategy of bates and swift (p. f. bates and r. a. swift, 1983, gene 26, 137-146). a library of salmonella typhimurium chromosomal dna was made usin ... | 1987 | 2829254 |
| studies on locus expansion, library representation, and chromosome walking using an efficient method to screen cosmid libraries. | we have developed an efficient screening method to search for clones in cosmid libraries prepared from human genomic dna. genomic, cdna, and cosmid probes have been used to isolate homologous cosmids from human chromosomes 7, 10, 16, 17 and x as part of a search for polymorphic nucleotide sequences. this method has been successfully applied to chromosome walking experiments at the interstitial retinol-binding protein locus on chromosome 10, and may be a useful tool for investigating representati ... | 1988 | 2906313 |
| role of alcohol dehydrogenase in the swift increase in alcohol metabolism (siam). studies with deer mice deficient in alcohol dehydrogenase. | previous studies have shown that rates of ethanol metabolism increase markedly 2-4 hr after the administration of ethanol in rats and in four inbred strains of mice. this phenomenon, called the swift increase in alcohol metabolism (siam), also exists in humans. to determine whether alcohol dehydrogenase (adh) is necessary for the siam response, we compared ethanol metabolism in two strains of the deer mouse, peromyscus maniculatus. one strain lacks alcohol dehydrogenase (adh-negative), whereas t ... | 1985 | 2932115 |
| plasma acth and corticosterone responses to limbic kindling in the rat. | changes in plasma acth and corticosterone concentrations were measured in individual cannulated rats at stages 1 and 5 of limbic kindling induced by electrical stimulation of the basolateral amygdala or the dorsal hippocampus. at both stages, a stimulation of either structure produced swift surges, first of acth and then of corticosterone. at stage 5 of hippocampal stimulation, acth baseline concentrations were four times higher than in the controls. the results are discussed in relation to the ... | 1986 | 3011488 |
| evidence for two cellular pathways of renin secretion by the mouse submandibular gland. | the pathway of renin secretion has been defined in the mouse submandibular gland (smg). renin is first synthesized as a prorenin, rapidly cleaved to a one-chain renin, and then very slowly processed to a two-chain form which is stored in mature granules. in pulse-labeling experiments of minced smg, the swift appearance in the culture medium of radiolabeled one-chain renin, before granule formation, suggested that this form was secreted by a constitutive pathway independent of the granules, possi ... | 1988 | 3046923 |
| central nervous system oxygen toxicity in the resting rat: postponement by intermittent oxygen exposure. | intermittent o2 breathing is a proven means of delaying pulmonary o2 toxicity during exposure to hyperbaric oxygen. the effect of an intermittent exposure in the pressure range toxic to the cns was studied. conscious, unrestrained rats, implanted with cortical eeg electrodes were subjected at 5 and 6 ata to alternating periods of 7 min o2 and 7 or 10 min of either air, normoxic nitrox, or n2o-air (the latter mixture being equinarcotic to pure o2). altogether, nearly half of the animals survived ... | 1988 | 3201631 |
| epidemiology of human rabies post-exposure prophylaxis in bangkok, 1984-1986. | a study was conducted to determine the current situation of human rabies post-exposure prophylaxis (pep) in bangkok for the period 1984-1986. a review of all bangkok residents receiving pep at the queen saovabha memorial institute revealed an increasing incidence rate of pep from 10.1 cases per 10,000 persons in 1984 to 12.6 cases per 10,000 persons in 1986. the highest incidence rate was observed in young males aged 5-14 years. about 68% of individuals receiving pep had exposures to bites, espe ... | 1988 | 3238466 |
| [yersinia enterocolitica septicemia in a girl with thalassemia major]. | the authors report the case of a child affected with thalassemia major who has presented a yersinia enterocolitica infection in a septicemial form. they point out that the clinical overture and its swift evolution with heart involvement make the diagnosis and the treatment difficult and, at the same time, urgent. they talk about the conditions which promote the septicaemia in this hemopathy. | 1988 | 3244546 |
| [clinical and experimental study on vascular reconstruction for one-kidney renovascular hypertension]. | several special problems were noted regarding the vascular reconstruction for renovascular hypertension of the patient with a solitary kidney. it is difficult to use the value of plasma renin activity for decisive diagnosis or determination of surgical indications because most of the one-kidney patients with renovascular hypertension showed a normal plasma renin activity preoperatively and it is theoretically impossible to obtain a ratio of the affected to the opposite renal vein renin level. mo ... | 1987 | 3320740 |
| effects of lesion of paramedian pontomedullary reticular formation by kainic acid injection on the visually triggered horizontal orienting movements in the cat. | a localized lesion was made in the nucleus reticularis pontis caudalis (nrpc) and the nucleus reticularis gigantocellularis (nrg) by kainic acid injection, and its effects on visually triggered orienting eye and head movements in the horizontal direction were investigated in alert head-free cats. before the lesion, trained cats could orient the head and eyes to the target presented in the periphery of the visual field, with rapid eye (saccade) and swift head movements. after the unilateral lesio ... | 1988 | 3380346 |
| an oocyst-transmitted outbreak of toxoplasmosis: patterns of immunoglobulin g and m over one year. | sera from 32 patients who became ill after jungle combat training were tested for antibodies to toxoplasma gondii using the indirect immunofluorescence test. swift rises of both igg and igm antibodies occurred within 2 weeks of infection. reduction in igm titers, due to competitive suppression by igg antibody, occurred in most but not all cases. suppression of igm reaction by igg antibody could be prevented by adsorption of serum with staphylococcus aureus containing protein a. antibody of the i ... | 1986 | 3513646 |
| observations on the energy and redox state and protein synthetic rate in animal and human placentas. | the energy and redox states of placentas in newly anesthetized or sacrificed guinea pigs and sheep were compared with that of human placentas immediately after delivery. subsequently the effect of ischemia was observed in both human and animal placentas. the influence of perfusion, using a fluid containing oxygenated red cells (adult human) was studied in the human placenta. adenine nucleotide precursors were added to the perfusion fluid in an attempt to improve the energy and redox states and t ... | 1987 | 3585680 |
| acute spinal epidural empyema. observations from seven cases. | seven cases with an acute epidural spinal empyema are presented. the best results are observed in cases with early treatment. since this rare condition is not widely known and swift diagnosis and treatment is imperative, it is stressed that immediate referral of the patient with back pain and any signs of infection in addition to commencing neurological abnormalities to a neurological unit for myelography can be vital or can at least reduce the risk of permanent paraplegia. | 1985 | 3883707 |
| activation of n-ras in a human melanoma cell line. | dna isolated from cell line mel swift, a human melanoma cell line, transforms nih3t3 cells. southern blot analysis of dna from secondary foci revealed conserved 8.8- and 7.8-kilobase ecori fragments which hybridized with a human repetitive sequence clone, blur 8. the activated transforming gene was identified as n-ras, and the 8.8-kilobase ecori fragment from a secondary transformant was cloned. synthetic 17-mer oligonucleotides which spanned either the normal codon 61 (caa) or a mutant codon 61 ... | 1985 | 3887133 |
| [identification of staphylococci of clinical importance: evaluation of available commercial kits and technical notes on the reduction of response time and cost of performance]. | a study was carried out on 150 strains of staphylococci of human origin in order to evaluate the possibility of achieving identification that is accurate, swift and perhaps economical, with the following aims in mind: a) the testing of fast systems for the detection of coagulase of staphyslide and sero stat compared with classical coagulase in a test tube with edta and citrate; b) the evaluation of the api staph system by comparing identification obtained through subculturing the strains in agar ... | 1985 | 3915104 |
| effect of latex-stimulated granulocytes on platelet aggregation in man. | the effect of granulocytes on human platelet aggregation was investigated in vitro. platelet function was assayed by photometric technique. incubation of platelets with latex-stimulated granulocytes for 1 h at room temperature resulted in total inhibition of arachidonic acid-induced platelet aggregation. adp-induced platelet aggregation was suppressed, lacked secondary wave and was pursued by swift disaggregation. platelet aggregates induced by collagen dispersed faster under the influence of st ... | 1985 | 3928458 |
| role of hormones in the mechanism of the swift increase in alcohol metabolism in the rat. | gastric intubation of female sprague-dawley rats (80--150 g) with one large dose (5 g/kg) of ethanol doubled both hepatic oxygen uptake and ethanol metabolism within 2.5 hr in the perfused rat liver (swift increase in alcohol metabolism--siam). hepatic oxygen uptake could also be elevated by direct infusion of epinephrine and glucagon into the perfused liver. alcohol treatment produced significant increases in circulating epinephrine, norepinephrine and glucose but did not effect levels of plasm ... | 1980 | 6113604 |
| erythrocytic phosphates and flying activity in birds. | 1. the intraerythrocitary organic phosphates in different avian species (sturnus vulgaris, apus apus, gallus gallus domesticus, coturnix coturnix japonica and columba livia) were analyzed by ionic exchange chromatography. the chromatograms of these species revealed the presence of adp, atp, gtp, ipp and inorganic phosphate. 2. the main organic phosphates (atp and ipp) and the inorganic phosphate were also evaluated, directly, in other specimens. the ipp levels were very similar in all species; h ... | 1983 | 6132731 |
| the swift increase in alcohol metabolism. | gastric intubation of female sprague-dawley rats with 5 g of ethanol/kg body wt doubled oxygen and ethanol uptake by the isolated perfused rat liver after only 2-5 h of treatment (swift increase in alcohol metabolism). diminished atp generation via glycolysis accounts for a portion of the increased oxygen uptake. these data indicate that at least part of the stimulated oxygen uptake after treatment with ethanol is a result of lower rates of glycolytic atp generation resulting from hormone action ... | 1981 | 6211337 |
| morphologic investigations on the rebound phenomenon after corticosteroid-induced atrophy in human skin. | cutaneous atrophy was induced on the forearms of 4 volunteers by continuous occlusive application of clobetasol-17-propionate for 6 weeks, after which time the steroid was discontinued. epidermal and dermal changes during the subsequent rebound "flare" were monitored for 2 weeks by light and transmission electron microscopy. an exuberant hyperplasia characterized the epidermal response. within 2 days poststeroid, most basal cells displayed fine structural features typical of highly proliferating ... | 1984 | 6368701 |
| methanol poisoning. | methanol poisoning is an uncommon but an extremely hazardous intoxication. since methanol is a versatile fuel and is having increasing usage in an energy-conscious society, a high index of suspicion and swift laboratory confirmation is essential in managing this poisoning. methanol poisoning may occur in sporadic or epidemic circumstances. chronic exposure may occur in the occupational setting. man is uniquely susceptible to methanol toxicity, perhaps dependent upon folate metabolism. classic sy ... | 1983 | 6386968 |
| the calcium channel blockers: pharmacology and clinical applications. | the calcium channel blockers provide an exciting and effective new therapeutic tool in the management of ischaemic cardiac syndromes and may prove popular and effective in the treatment of a variety of other disorders. they have provided a new approach to treatment and have added new insights into the pathogenesis of ischaemic cardiac syndromes. their introduction into clinical practice has been swift and many of our concepts regarding their pharmacologic activities in man remain based on theore ... | 1983 | 6400754 |
| isolation and characterization of rat pancreatic elastase. | proelastase has been purified to homogeneity from rat pancreatic tissue by a combination of cm-sephadex and immobilized protease inhibitor affinity resins. trypsin activation yields an elastolytic enzyme that possesses a specificity toward small hydrophobic residues in synthetic amide substrates, similar to those of porcine elastase 1 and canine elastase. however, the rat enzyme also rapidly hydrolyzes a substrate containing tyrosine in the p1 position. n-terminal sequence analysis reveals that ... | 1983 | 6555050 |
| electromyogram premotion silent period and tension development in human muscle. | the emg silent period has been observed frequently just before rapid movement from a slightly sustained contraction of the muscle. our experiments were designed to show the relation between the tension developed in an intact human muscle and the occurrence of this silent period. tension in the knee extensor was obtained from the floor reaction force of a living subject in a squatting position on the basis of a lever ratio-joint angle diagram obtained directly from measurements on an isolated kne ... | 1983 | 6628618 |
| eight hundred and seventy-five cases of bacterial meningitis. part i of a three-part series: clinical data, prognosis, and the role of specialised hospital departments. | between 1966 and 1976, 875 patients with bacterial meningitis were treated at the department of infectious diseases, rigshospitalet. among 495 patients admitted directly to the department, fatality rates were 0.4 per cent for meningococcal infections (including septicaemia), 3.7 per cent for haemophilus meningitis and 8.7 per cent for pneumococcal meningitis. the total fatality rate for directly admitted patients was 3.8 per cent, and 4.0 per cent had sequelae on discharge. patients transferred ... | 1983 | 6631026 |
| n6-trimethyl-lysine metabolism. 3-hydroxy-n6-trimethyl-lysine and carnitine biosynthesis. | rats injected with n6-[me-3h]trimethyl-lysine excrete in the urine five radioactively labelled metabolites. two of these identified metabolites are carnitine and 4-trimethylammoniobutyrate. a third metabolite, identified as 5-trimethylammoniopentanoate, is not an intermediate in the biosynthesis of carnitine; the fourth and major metabolite, n2-acetyl-n6-trimethyl-lysine, is not a precursor of carnitine. the remaining metabolite (3-hydroxy-n6-trimethyl-lysine) is converted into trimethylammoniob ... | 1980 | 6772168 |
| [variations of testosterone uptake by gonadotropic cells of the adenohypophysis of the rat]. | testosterone (t) could be detected by immunocytochemistry after cryoultramicrotomy and t is likely bound on a binding site of a high affinity. castration and adrenalectomy involve a swift disappearance of t in the gonadotropic cells. synthesis of new binding sites was induced by daily t injection in the castrated and surrenalectomized rat from 90 days. this synthesis is inhibited by cycloheximide. these data suggest that binding sites are proteins. the captation of t by the gonadotropic cells wa ... | 1980 | 6773694 |
| [fundamental and experimental studies on fetal biochemical monitoring accomplished by ion-sensitive field-effect transistor ph and pco2 sensors]. | materno-fetal ph and pco2 were measured continuously, using newly-developed transistor ph and pco2 sensors placed in both arteries and peripheral tissues of 12 pregnant goats near term. maternal bp, fhr and fetal tcpo2 were also recorded simultaneously. as results: (1) maternal oxygen inhalations caused consistent increases of fetal tcpo2 from 21 to 29 mmhg, in average. (2) when various concentrations of co2 were inhaled by the mother, maternal paco2 rapidly increased to peak levels near to fico ... | 1982 | 6816875 |
| classical syndromes in occupational medicine: dimethylaminopropionitrile. | dimethylaminopropionitrile, used as a catalyst in the manufacture of polyurethane, was responsible for two epidemics of urinary retention, sexual dysfunction, and peripheral neuropathy in 1978. most affected workers recovered promptly, but some have had persisting neuropathy, sexual and bladder dysfunction, and cns symptoms. the mechanism of neurotoxicity appears to be interference with axoplasmic transport. the catalyst that caused the problem was withdrawn from the market after swift governmen ... | 1983 | 6846342 |
| spinal epidural abscess. | eighteen patients with spinal epidural abscess were seen at the tientsin medical college hospital 1957-1977. presentation was uniform, with back pain and local tenderness, fever and leucocytosis, then the appearance of neurologicaspol deficit, tending to paraplegia with 48 hours. there had been an infection elsewhere in 14 cases, one followed vertebral osteomyelitis and in three the origin was unknown. diagnosis was made by lumbar puncture, either by aspiration of pus or myelography. the infecti ... | 1982 | 6954387 |
| the swift increase in alcohol metabolism. time course for the increase in hepatic oxygen uptake and the involvement of glycolysis. | gastric intubation of female sprague-dawley rats with 5 g of ethanol/kg body wt. nearly doubled oxygen uptake by the isolated perfused rat liver maximally after only 2.5 h of treatment (swift increase in alcohol metabolism). inhibition of enhanced oxygen uptake by kcn (2mm) and 4-methylpyrazole (0.8 mm) suggested the involvement of the mitochondrial respiratory chain and alcohol dehydrogenase in this phenomenon. glycolysis was depressed after ethanol treatment. diminished atp generation via glyc ... | 1980 | 6989357 |
| is the race not always to the swift? | | 1982 | 7062948 |
| diazepam reverses bombesin-induced gastric spasms and food intake reduction in the rat. | bombesin (2-16 micrograms/kg, i.p.) produced abnormally large gastric contractions in intact rats consisting of increases in gastric pressure and motility. the effect was antagonized by diazepam (5 mg/kg, i.p.). the same dosage of diazepam abolished bombesin-induced food intake reduction. diazepam by itself did not increase food intake above control levels. the time course of this behavioral antagonism was followed. there was no significant difference in the intake time course of diazepam-alone ... | 1982 | 7073887 |
| swift increase in alcohol metabolism (siam) in the mouse: comparison of the effect of short-term ethanol treatment on ethanol elimination in four inbred strains. | ethanol metabolism increases 2 to 3 hr after the administration of ethanol. this phenomenon, called the swift increase in alcohol metabolism, has been compared in four inbred strains of mice (dba/2j, c3h/hej, akr/j and c57bl/6j). basal rates of ethanol elimination were determined in individual mice after an i.p. injection of ethanol (2 g/kg). little variability in this basal rate of ethanol elimination was observed within each strain. mice were then exposed to ethanol vapor (20--22 mg/l) and rat ... | 1982 | 7120126 |
| the swift increase in alcohol metabolism. inhibition by propylthiouracil. | administration of a single large dose of ethanol (5 g/kg) to rats elevates the rates of ethanol metabolism and of oxygen consumption in perfused livers in 2-3 hr. pretreatment with the antithyroid drug propylthiouracil (ptu) for 10 days abolished both of these effects. under all treatment conditions studied (controls; ptu-pretreatment; acute ethanol treatment; ptu-pretreated + acute ethanol treatment),, a significant correlation between ethanol metabolism and oxygen consumption was observed (r = ... | 1982 | 7126252 |
| changes in lipid content during the post-hatching development of the brain of altricial birds. | the post-hatching development of the brain was studied in three altricial birds (those whose development is completed after hatching), namely, the domestic pigeon, house swift and house sparrow, to assess the state of maturity of the brain at the time that the fledglings leave the nest. maturity is related to the process of myelination and, therefore, sudan black was chosen as it is a sensitive indicator of myelin lipids. on hatching, it was found that sudanophilia was very low in all three bird ... | 1981 | 7251396 |
| monoamine oxidase in brain maturation: a histochemical study during posthatching development in altricial birds. | monoamine oxidase was studied histochemically in the brain of three altricial birds, domestic pigeon house swift and house sparrow, during posthatching development. it was found that there was a steady increase in the activity of the enzyme in all areas of the brain of the three birds. the medulla and thalamus showed adult pattern of maturation by 15-20 days in sparrow while the optic lobes and cerebellum did so by 25 days in the former and 11 days in the latter. the cerebral hemispheres showed ... | 1981 | 7264281 |
| death and injury from motor vehicle crashes in israel: epidemiology, prevention and control. | death and motor vehicle crash (mvc) rates per 1000 vehicles and kilometres travelled in israel (1977) exceed those of all western countries, despite low numbers of young and intoxicated drivers. increased casualties have resulted from expansion of driver and vehicle populations offsetting a decline in crash risk. time data indicate casualty crash trends reflect trends in traffic volume, and that night time case fatality rates (cfr) are high. place data indicate that more than three quarters of a ... | 1981 | 7287274 |
| a perspective on forage production in canada. | over the past decade, the cattle industry has experienced practically a full circle. with the promising beef prices in the early 1970s, with the glut of grain and a generous assist from government incentive programs, the forage acreage and cattle population have increased at a record rate. by 1974, the tide began to turn - grain prices went up sharply and beef prices became sluggish - and by 1976 a major crisis faced the producers. the cattle industry which had been developing on a cheap grain e ... | 1980 | 7363269 |
| mechanism of the swift increase in alcohol metabolism ("siam") in the rat. | gastric intubation of female sprague-dawley rats (80-150 g) with one large dose (5 g/kg) of ethanol nearly doubled oxygen uptake of the isolated, perfused rat liver in only 2.5 hours. this increased hepatic respiration can account for the swift increase in alcohol metabolism (siam). inhibition of enhanced oxygen and ethanol uptake by kcn (2 mm) and 4-methylpyrazole (0.8 mm) indicated the involvement of the mitochondrial respiratory chain and alcohol dehydrogenase in this phenomenon, respectively ... | 1980 | 7424736 |
| [predictive value of ultrasonography in the study of aortic abdominal aneurysms]. | several authors have collected a great deal of data in the study of abdominal aorta aneurysm through the swift diffusion of ultrasonography in the abdominal diagnostics. the authors illustrate their experience confirming the excellent reliability of ultrasonography in the diagnosis of abdominal aorta aneurysms with respect to other methods of imaging (angiography, cat, etc) not with a view to replacing them but as a useful means of screening. | 1995 | 7478061 |
| antimicrobial activity and biosynthesis of indole antibiotics produced by xenorhabdus nematophilus. | we have investigated the mechanism of action and physiology of production of the indole derivative antibiotics produced by the nematode-associated, entomopathogenic bacterium xenorhabdus nematophilus. maximum antibiotic concentration was reached during the late stationary phase of growth, and the antibiotic yield was appreciably enhanced by supplementation with tryptophan. antibiotic biosynthesis apparently involved the removal of the side-chain carboxyl (c-1) carbon of tryptophan. the c-3 methy ... | 1993 | 7510325 |
| proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosis. | apoptosis leads to swift recognition, ingestion, and degradation of intact senescent neutrophils by macrophages. this protects tissues from leakage of noxious contents from dying cells and may promote resolution of inflammation. however, little has been known of the mechanisms that regulate macrophage capacity for apoptotic cells during an inflammatory response. we examined whether proinflammatory cytokines modulated phagocytosis of senescent neutrophils undergoing apoptosis by human monocyte-de ... | 1995 | 7532668 |
| use of antimicrobial agents in official abattoirs under meat inspection in the united states of america. | facilities and equipment which are contaminated by a diseased carcass during slaughter and processing operations must be made free from microorganisms of human health concern before being used again. therefore, a rapid-acting microbicidal agent is necessary to enable the swift resumption of operations. currently, water heated to 180 degrees f (82.2 degrees c) is the antimicrobial agent of choice, as this rapidly kills microbes without leaving a residue which could jeopardize food products. | 1995 | 7579633 |
| the immune self: a selectionist theory of recognition, learning, and remembering within the immune system. | in this paper, i have briefly explored metaphors shared by the immune and nervous systems and shown that this exercise can lead to the elucidation of common principles of organization, as well as to predictions concerning how the immune system functions. metaphor itself undoubtedly reflects the way in which we categorize and retrieve information 44], so it is not surprising that the deep processes of language tend to sample information from related data categories. although the nervous and immun ... | 1995 | 7659491 |
| cyclic nucleotide changes induced in human leukocytes by a product of axenically grown entamoeba histolytica that inhibits human monocyte locomotion. | pulse exposure of human mononuclear phagocytes to the monocyte locomotion-inhibitory factor produced by entamoeba histolytica (i.e., the 369- to 765-da chromatographic fraction obtained from the supernatant fluid of axenically grown e. histolytica) led to a swift increase in the intracellular concentration of adenosine 3':5' cyclic monophosphate (camp). a weaker response was observed in human polymorphonuclear leukocytes, the locomotion of which, however, is not inhibited by this amebic factor. ... | 1995 | 7731924 |
| particle inhalability curves for humans and small laboratory animals. | several inhalability curves for nose breathing in humans have been developed. no studies have been designed specifically to develop inhalability functions for animals, although it has been shown that pulmonary deposition of large particles (> 4-5 microns) via inhalation is minimal in laboratory animals [raabe et al., inhaled particles vi, pp. 53-63. pergamon press, oxford (1988)]. the logistic function was fitted to these animal deposition data of raabe et al. (1988) to estimate an inhalability ... | 1995 | 7793751 |
| dna-dna hybridization-based phylogeny for "higher" nonpasserines: reevaluating a key portion of the avian family tree. | a matrix of delta t mode values for 10 birds, including 9 nonpasserines and a suboscine passerine flycatcher, was generated by dna-dna hybridization. within the most derived lineages, all bootstrapped and jackknifed fitch trees lend strong support to sister-groupings of the two swift families, of hummingbirds to swifts, and of these to a clade containing both owls and night-hawks. the outgroup duck roots the tree between the woodpecker (piciformes) and the remaining taxa, indicating that picifor ... | 1994 | 7820288 |
| sequencing of the ovine interleukin-8-encoding cdna using the polymerase chain reaction. | the nucleotide (nt) sequence encoding the ovine homologue of interleukin-8 (il-8) was determined. the mrna is 1494-nt long with an orf of 101 codons. the long 3' non-coding element contains several attta repeats implicated in the swift turnover of other chemokine mrnas. the encoded protein of 11 kda before processing, and 9 kda as mature protein, contains the cys-xaa-cys motif common to alpha-chemokines, and has conserved amino acids (aa) at positions identified as receptor contact sites for il- ... | 1994 | 7821808 |
| induction of apoptotic cell dna fragmentation in human cells after treatment with hyperthermia. | the biological significance of apoptosis is becoming increasingly clear. its relevance in tumor response to treatment as well as recent evidence for its important function as a regulating mechanism in tumorigenesis has also been demonstrated. one of the most prominent biological features of apoptosis is nucleosomal dna fragmentation. in this communication, we present a study of dna fragmentation in raji cells which have been subjected to hyperthermia treatment to induce apoptosis. we found that ... | 1995 | 7889527 |
| rejection of intraocular tumors from transgenic mice by tumor-infiltrating lymphocytes. | the present study examined the role of tumor infiltrating lymphocytes (til) in the rejection of intraocular tumors from sv40 transgenic mice. tumor cells from an intraocular tumor arising in an sv40 transgenic fvb/n mouse were transplanted into the eyes of syngeneic fvb/n mice and the til isolated. til were assessed for direct cytolytic activity in vitro. til were also transferred passively to immunosuppressed fvb/n mice to determine if they could mediate intraocular tumor rejection. the role of ... | 1994 | 7914482 |
| apoptosis and the kidney. | apoptosis is a programmed form of cell death mediating the precisely controlled deletion of "unwanted" cells. this review discusses the key features of this cell death program, emphasizing that apoptosis is regulated by factors extrinsic and intrinsic to the dying cell. furthermore, because apoptosis leads to the swift phagocytic clearance of intact cells, tissues are protected against the noxious effect of cell contents. apoptosis occurs in the developing and adult kidney, and nephrologists now ... | 1994 | 7948779 |
| mirizzi syndrome treated by percutaneous stone removal. | we report a case of mirizzi syndrome due to a cystic duct stone occurring in a 66-year-old man in the presence of multiple debilitating medical conditions which precluded surgery. the patient was successfully treated by percutaneous stone removal and made a swift and uneventful recovery. this is the first report of mirizzi syndrome due to a ductal stone being treated in this manner. | 1994 | 7954575 |
| behavioral profiles of adult rats in a difficult food supply social situation, related to certain early behavioral features. | behavioral profiles of male rats were defined in nine intralitter groups of six individuals at various stages of their development: (a) at pup stage in individual situations (uncomfortable positions) and social situations (removal away from the mother), and (b) at adult stage in a difficult food supply social situation (complete immersion of the food access way). the male population was split into two sets, both at pup stage (the most and the least swift and efficient of each group to overcome u ... | 1994 | 8034115 |
| extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals. | the concentration of extracellular glucose in anesthetized rat brain was measured continuously with two types of substrate-specific microelectrodes in a number of physiological and pathological conditions. extracellular glucose level increased in hyperglycemia and decreased in hypoglycemia, paralleling the changes in blood sugar. increased neuronal activity and in particular spreading depression, evoked triphasic alterations in extracellular glucose concentration: an initial rapid fall was follo ... | 1994 | 8046468 |
| a carnivore species (canis familiaris) expresses circadian melatonin rhythm in the peripheral blood and melatonin receptors in the brain. | dogs kept under controlled photoperiodic conditions of 12 h light and 12 h dark expressed a clear diurnal melatonin rhythm in the peripheral blood, with a swift peak restricted to the late part of the scotophase. the highest density of high-affinity, g-protein-linked 2-[125i]iodomelatonin binding sites was found in the pars tuberalis of the pituitary gland. binding sites were found also in the pars distalis, and light microscopy/high-resolution autoradiography showed that binding was located exc ... | 1994 | 8075790 |
| xenorecognition and xenoimmunity. | human t lymphocytes can respond against pig stimulator cells according to a direct pathway of activation, indicating that no major differences exist between human t cell mediated alloresponses and xenospecific responses against pig stimulator cells in vitro. however, even if pig pbmc can activate t cells directly, it is believed that porcine islet cell clusters are incapable of activating cellular immunity directly in vivo, since icc xenotransplants are thought to lack antigen-presenting cells. ... | 1994 | 8090567 |
| rapidly fatal necrotising fasciitis caused by streptococcus pyogenes. | to describe the morbid anatomical and bacteriological features in a series of five cases of rapidly fatal streptococcus pyogenes necrotising fasciitis. | 1993 | 8157746 |
| the role of anions in ph regulation of leishmania major promastigotes. | the ph regulation of leishmania major promastigotes was studied as a function of the ionic composition of the medium and in response to acid and alkali load. intracellular ph (phi) was monitored by on-line ratio fluorescence using the fluorescence-dependent ph indicator 2',7'-bis-(carboxyethyl)-5,6-carboxyfluorescein (bcecf). in cl(-)-based medium (ph 7.4, 30 degrees c), the steady state phi was maintained at 6.75 +/- 0.01. only a minor (< or = 0.07 +/- 0.02 unit) decrease in steady state phi wa ... | 1994 | 8206930 |