| some properties and the complete primary structures of two reduced and s-carboxymethylated polypeptides (s5c1 and s5c10) from dendroaspis jamesoni kaimosae (jameson's mamba) venom. | two polypeptides (protein s5c1 and toxin s5c10) were purified from dendroaspis jamesoni kaimosae venom. whereas protein s5c1 comprises 61 amino acid residues, toxin s5c10 contains 58 and they each comprise four disulphide bridges. the complete primary structures of the two polypeptides have been elucidated. the sequences of protein s5c1 and toxin s5c10 are structurally homologous to the short neurotoxins type i, but they are much less toxic. in toxin s5c10 one of the functionally invariant amino ... | 1979 | 465532 |
| an efficient analytical platform for on-line microfluidic profiling of neuroactive snake venoms towards nicotinic receptor affinity. | venomous snakes have evolved their efficient venomous arsenals mainly to immobilize prey. the highly variable toxic peptides in these venoms target a myriad of neurotoxic and haemotoxic receptors and enzymes and comprise highly interesting candidates for drug discovery. discovery of bioactive compounds from snake venoms, however, is a challenge to achieve. we have developed and applied a methodology to rapidly assess bioactives in a snake venom proteome. our microfluidic platform opens up effici ... | 2013 | 23159399 |
| the primary structure of a short neurotoxin homologue (s4c8) from dendroaspis jamesoni kaimosae (jameson's mamba) venom. | | 1980 | 7428994 |
| characterization of the lower-molecular-mass fraction of venoms from dendroaspis jamesoni kaimosae and micrurus fulvius using capillary-electrophoresis electrospray mass spectrometry. | capillary electrophoresis (ce) with electrospray ionization (esi) and selected ion-monitoring mass-spectrometric (sim-ms) detection has been used to provide as much information as possible about the lower molecular-mass fraction (peptides of molecular masses up to 8500 da) of the venoms of dendroaspis jamesoni kaimosae (jameson's mamba) and micrurus fulvius (eastern coral snake). method development was based on the venom of d. jamesoni kaimosae, which contains some previously described peptides, ... | 1995 | 8521847 |
| structure-activity studies of homologues of short chain neurotoxins from elapid snake venoms. | three neurotoxin homologues (cm10 and cm12 from naja haje annulifera and s5c10 from dendroaspis jamesoni kaimosae) and two short neurotoxins (cm14 from naja haje annulifera and erabutoxin b from laticauda semifasciata) were examined by circular dichroism (c.d.) and tested for neuromuscular activity on chick biventer cervicis nerve-muscle preparations. all three homologues had acetylcholine receptor blocking activity, as they abolished responses to indirect stimulation, acetylcholine and carbacho ... | 1984 | 6743920 |
| snake venoms. the amino-acid sequence of protein s2c4 from dendroaspis jamesoni kaimosae (jameson's mamba) venom. | a major component (s2c4) was purified from jameson's mamba by gel filtration on sephadex g-50 and ion-exchange chromatography on cm-cellulose. protein s2c4 comprises 62 amino acid residues including 8 half-cystine residues. the complete amino acid sequence of the protein has been established. the sequence and the invariant amino acid residues of protein s2c4 resemble a short neurotoxin, a long neurotoxin, a cytotoxin and an angusticeps type protein. however, the position of its four disulphide b ... | 1979 | 437703 |
| snake venoms. the amino-acid sequence of protein s5c4 from dendroaspis jamesoni kaimosae (jameson's mamba) venom. | a major component (s5c4) was purified from jameson's mamba by gel filtration on sephadex g-50 and by ion-exchange chromotography on cm-cellulose. protein s5c4 contains 60 amino acid residues and is cross-linked by four intrachain disulphide bridges. the complete primary structure of the protein has been elucidated. the toxicities, the immunochemical properties, the sequence and the invariant amino acid residues of protein s5c4 resemble subgroup ii of the angusticeps-type proteins. | 1978 | 669583 |
| snake venom toxins. the amino acid sequences of two toxins from dendroaspis jamesoni kaimosae (jameson's mamba) venom. | | 1973 | 4204636 |