| purification and characterization of a cytotoxic neurotoxin-like protein from naja haje haje venom that induces mitochondrial apoptosis pathway. | this study reported the purification and characterization of a cytotoxic, neurotoxin-like protein derived from the venom of the egyptian cobra naja haje haje, elapidae family, and explored their mechanistic role in the cell death. the protein purification was performed through ion-exchange chromatography and gel-filtration chromatography and was characterized by sds-page, amino acid sequencing, and mass spectrum analysis. the antitumor activity of naja haje venom (nhv) and its fractions (nhvi, n ... | 2011 | 21240479 |
| complete amino acid sequence and phylogenetic analysis of a long-chain neurotoxin from the venom of the african banded water cobra, boulengerina annulata. | the sequence of a long-chain neurotoxin (71 amino acid residues, 10 half-cystines) from the venom of the african banded water cobra (boulengerina annulata) was determined by edman degradation. it exhibits high sequence similarity with long-chain neurotoxins from the venoms of four species of african cobras (genus naja), which are collectively more similar to the boulengerina toxin than to those of asian naja species. these results are discussed in the light of phylogenetic hypotheses on the rela ... | 2004 | 15284021 |
| lethal toxins and cross-neutralization of venoms from the african water cobras, boulengerina annulata annulata and boulengerina christyi. | venoms of the water cobras, boulengerina, were assayed for lethality, proteolytic activity and protein content. boulengerina annulata annulata and b. christyi venoms averaged 89% protein and lacked proteolytic activity. the murine i.p. ld50 of b. a. annulata and b. christyi venoms were 0.143 and 0.120 mg/kg, respectively. polyvalent antivenom produced by the south african institute of medical research neutralized 575 and 200 ld50 of b. a. annulata and b. christyi venoms/ml antivenom, respectivel ... | 1991 | 1814007 |