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presence of angiostrongylus cantonensis at la réunion.the eosinophilic meningitis due to angiostrongylus cantonensis is well known on madagascar and on mauritius island, but was never described on reunion island. two cases have been lately oberved in doctor jay's department at gabriel martin's hospital. local achatines were dissected and contained larvae which, when absorbed by rats, were found in there brains ten days later. these larvae belong certainly to angiostrongylus genus, but the species has not yet been found with certitude. lately infest ...19757126
angiostrongylus cantonensis: preparation of a specific antigen using immunoadsorbent columns. 197551799
the humoral and cell-mediated immune responses to somatic and metabolic antigens in rats infected with angiostrongylus cantonensis. 197886211
occurrence of angiostrongylus cantonensis in the heart of a spider monkey. 1978102677
effects of various numbers of adult angiostrongylus cantonensis on lung lysophospholipase activities and bone marrow eosinophil levels of specific pathogen-free rats. 1978153956
eosinophilic meningitis in tahiti: clinical study of 54 patients.eosinophilic meningitis is due to infestation of the nervous system by the larvae of angiostrongylus cantonensis. the infection is from infected prawns and slugs. in a study of 54 patients from tahiti the leading symptoms were headaches, neck stiffness, limb pains and sometimes a facial palsy. the diagnosis is made by examination of the csf when the leucocytes are usually over 100/mm3 and over half are eosinophilic cells. the blood eosinophil count is often raised, above 400/mm3. the disease is ...1978283329
acquired resistance and immune responses of eight strains of inbred rats to infection with angiostrongylus cantonensis. 1979314012
immunodiagnosis of parasitic zoonoses: comparative efficacy of three immunofluorescence tests using antigens purified by affinity chromatography.three immunofluorescent antibody assays were developed during this study: the direct (dfat) and indirect (ifat) fluorescent antibody tests using frozen worm sections, and the cyanogen bromide indirect fluorescent antibody test (cnbr-ifat) using helminth antigens purified by affinity chromatography bound on to commercially prepared cnbr-sepharose 4b beads. purified antigens used in the cnbr-ifat gave greater specificity and sensitivity than either the dfat or ifat. dirofilaria immitis, toxocara c ...1978354114
food-borne parasitic infections--old stories and new facts.a review is presented of food-borne parasitic infections. parasitic infections with public health hazards both from conventional slaughter animals and from seafood (fish and shellfish) are discussed. the former category includes cysticercosis, echinococcosis, and trichinosis, the latter category covers various trematode, cestode, nematode, and possibly also protozoan infections. examples of trematode infections are heterophyidiasis, transmitted to man by marine fish, and paragonimus spp parasite ...1979369034
changes in worm burden, haematological and serological response in rats after single and multiple angiostrongylus cantonensis infections.thirteen groups of rats were first sensitized with single or double doses of 5--30 third-stage larvae of angiostrongylus cantonensis, followed by a challenge infection with 100 larvae at various periods after the primary infection. seven other groups of rats receiving only the sensitizing infection served as the controls. in all the sensitized rats, a significantly (p less than 0.05) smaller mean number of adult worms was found established in the challenge infection as compared to the control. t ...1979452645
recovery of angiostrongylus cantonensis from cerebrospinal fluid of a child with eosinophilic meningitis.viable angiostrongylus cantonensis was recovered from the cerebrospinal fluid of a 17-month-old boy with eosinophilic meningitis. neurological findings were minimal, and the child had an uneventful recovery.1979479360
host-parasite relationship of angiostrongylus cantonensis. 1. intracranial transplantation into various hosts.various stages of angiostrongylus cantonensis recovered from the brain of experimentally infected mice were transplanted intracranially into rats. third and fourth-stage worms recovered 2--7 days postinfection were able to develop normally after transplantation into recipient rats. the fifth-stage worm obtained 14--15 days postinfection would enter the brain tissue of rats but died shortly afterwards. however, the same stage of worms recovered from rats, after a similar transplantation, were fou ...1979479541
effect of vitamin a deficiency on susceptibility of rats to angiostrongylus cantonensis. 1979482296
angiostrongylus cantonensis: infectivity of first stage larvae in the presence of rat fecal materials as tested by the in vitro cultivation technique. 1979483014
cross-resistance between trichinella spiralis and angiostrongylus cantonensis in laboratory rats. 1979494711
[1st case of eosinophilic meningitis in reunion, probably due to angiostrongylus].report of the case of a six-year-old child who presented a meningitis with 40 % eosinophils in the cerebrospinal fluid and which spontaneously regressed. these clinical data and the serologic (positive test for many nematod antigens) and epidemiological findings (presence of angiostrongylus larvae in terrestrial gasteropod) lead to the conclusion that we were in presence of the first case of eosinophil meningitis due to angiostrongylus cantonensis reported in the island of la réunion.1977579615
[development of angiostrongylus cantonensis in the lung of achatina fulica (author's transl)].twenty-four achatina fulica from pai-sha of the pescardores islands, where no angiostrogylus cantonensis has been found in a. fulica(4), were inoculated with the first stage larvae of a cantonensis. one snail was killed every day after 24 days following inoculation. the lung of each snail was separated and examined for larvae under microscope. the same lung was then digested with pepsin. the larvae recovered after pepsin digestion were examined for more detailed morphology. this study confirmed ...1977580235
commercially available, edible snails otala lactea (müller) and helix aperta (born) as laboratory hosts of angiostrongylus cantonensis. 1977592047
epidemiological survey of angiostrongylus cantonensis in shimizu ship-port, shizuoka prefecture, japan. 1977598977
experimental double infection of biomphalaria glabrata snails with angiostrongylus cantonensis and schistosoma mansoni.two groups of biomphalaria glabrata snails primarily infected with angiostrongylus contonensis were secondarily exposed to infection with schistosoma mansoni. to investigate any anatagonistic effect of the first infection on a superimposed one and to compare to singly and non-infected snails, a series of experiments was undertaken in which snails were individually exposed, variously, to 1,000 and 2,000 first-stage larvae of a. cantonensis and then to 5 and 10 miracidia of s. mansoni 1 day and 3 ...1977605654
effect of immunization with metabolic antigens on experimental infection of rats with angiostrongylus cantonensis.immunization of rats with excretions and secretions from an in vitro culture fluid (es antigens) of adult female angiostrongylus cantonensis markedly enhanced their resistance to infection by third-stage larvae. mortality rate, survival period, worm development and worm recovery, determined after a lethal challenge with infective larvae, were compared in immunized and unimmunized animals. with regard to these criteria, the results obtained with animals that had been immunized with es antigens fr ...1977614709
acetylcholinesterase levels in angiostrongylus cantonensis in relation to the immune response in rats. 1978631982
nidality of eosinophilic meningitis with special reference to angiostrongylus cantonensis. 1978632707
angiostrongylus cantonesis infection of the brain of a captive bennett's wallaby (macropus rufogriseus).eleven immature adult angiostrongylus cantonensis were recovered from beneath the meninges of a captive bennett's wallaby (macropus rufogriseus) which died after displaying posterior paresis followed by paralysis and intermittent opisthotonic spasms of increasing frequency for 7 days. congestion and focal malacia with haemorrhage were seen in the brainstem and cerebellum. sections of worms with scanty inflammatory response were seen beneath the congested haemorrhagic leptomeninges of cerebrum an ...1978655984
the first record of angiostrongylus cantonensis from egypt.in this paper the first record of the medically important nematode parasite, angiostrongylus cantonensis, is made from egypt. a survey of eight species of freshwater gastropods collected from natural water courses and of three species of wild rats caught from the same areas revealed respectively, that the ampullarid snail lanistes carinatus acts as the intermediate host transmitting this parasite, and that the rat rattus norvegicus is its definitive host. the life cycle of the parasite was succe ...1978706552
transplantation of intracranial young adult angiostrongylus cantonensis into the subdural spaces of the brains of rats and guinea pigs. 1978713222
observations on the development of angiostrongylus cantonensis in mastomys and mongolian gerbils. 1978723108
effects of parasitism and stress on hemolymph protein of the african giant snail, achatina fulica.effects of parasitism and stress on the protein concentration of hemolymph have been investigated using the rat lungworm angiostromgylus cantonensis in the snail host achatina fulica. the normal hemolymph protein concentration, averaging 1.77 g/100 ml in noninfected snails, did not show any reduction when the hosts were infected with third stage larvae. when the infected snails were bled repeatedly, protein concentration showed a significant decrease by 0.6 g/100 ml. starved, infected snails wer ...1978735303
angiostrongyliasis in indonesia: additional geographic and host occurrence records.geographical and host occurrence records for angiostrongylus cantonensis throughout the indonesian archipelago a;e reported. a. cantonensis was found in the following provinces: west sumatra, south sumatra, lampung, west java, central java, north sulawesi and east nusa tenggara. infections were diagnosed in the following rodents: rattus rattus diardii, rattus exulans, rattus tiomanicus jaloriensis, rattus lepturus, rattus norvegicus and bandicota indica setifera and in the giant african land sna ...1978751218
parasitic diseases of the nervous system in thailand.in thailand there are 3 parasites that commonly cause neurological diseases in man. 1) in gnathostomiasis man becomes an accidental host by eating infected under-cooked fresh water fish. the tissue nematode involved, gnathostoma spinigerum, because of its high motility, may cause widespread damage in the spinal cord and brain stem. the common presenting neurological symptoms are severe nerve root pain, paralysis of limbs and urinary retention. less frequently seen are cranial nerve palsies and s ...1978756025
[histological studies of the african giant snail (achatina fulica) experimentally infected with angiostrongylus vasorum or angiostrongylus cantonensis (author's transl)].african giant snails (achatina fulica) about 6 weeks old were experimentally infected with each 5,000 to 20,000 first stage larvae of angiostrongylus vasorum or a. cantonensis by exposure to a larval suspension. the snails were histologically examined after various intervals after infection: 1 hour post infectionem (p.i.) larvae were present in the foot and 2 hours p.i. in addition in the gastrointestinal tract. 12 hours p.i. larvae were seen for the first time in the lung which reached nearly h ...1976790803
eosinophilic meningoencephalitis caused by the rat lung worm, angiostrongylus cantonensis with special reference to a. malaysiensis in malaysia. 1976822262
angiostrongylus cantonensis: phospholipase in nonsensitized and sensitized rats after challenge.rats given an initial infection with angiostrongylus cantonensis had moderately elevated phospholipase b activity in the lungs at 8 and 15 days after challenge, and greatly elevated levels were evident at 35, 43, and 49 days. in the brain, the values were elevated at 15 through 35 days. these periods of increased activity in the lungs and brain coincided with the migration patterns of the third stage larvae and the adult worms in this host. the elevated enzyme levels also were were correlated wi ...1977832897
ocular angiostrongyliasis in semarang, central java.a worm removed intact from the anterior chamber of the left eye of a 23-year-old woman from central java was identified as a mle angiostrongylus cantonensis, 11.1 mm in length and 0.24 mm in maximum width. a useful degree of eye function was preserved. five similar cases have been reported--three from thailand, two from south vietnam.1977842785
the mode of infection with and the distribution of angiostrongylus cantonensis larvae in the experimental intermediate hoist biomphalaria glabrata. 1977919700
letter: granulomatous encephalomyelitis of puppies due to angiostrongylus cantonensis. 1976971151
reaginic antibody productions in rabbits and rats infected with angiostrongylus cantonensis. 1976985982
growth and localization of angiostrongylus cantonensis in the molluscan host, achatina fulica.the development of the rat lung worm angiostrongylus cantonensis within the giant african snail achatina fulica is reported. in this host, ingested first stage larvae penetrate the intestinal wall into the hemocoel and migrate to the mantle where they undergo two molts and become third stage larvae within 24 days. the mantle, harboring 85% of the total number recovered is the major location of infective larvae. the kidney contains about 11% but few larvae are found in the remaining visceral org ...19761027104
the bandicoot rat, a new host record for angiostrongylus cantonensis in indonesia.a survey for angiostrongylus cantonensis in possible definitive and intermediate hosts was conducted in ancol, jakarta. adult worms were found in 43% of bandicoot rats, bandicota indica setifera, in 14% of rattus rattus diardii and 36% of the achatina fulica were infected with larval forms of the parasite. the finding of the parasite in the bandicoot rat constitutes a new host record for indonesia.19761027106
delayed hypersensitivity responses of guinea pig and rat to angiostrongylus cantonensis infection. 19761034844
[presence of angiostrongylus cantonensis in the réunion island. isolation of the strain].the detection of some cases of eosinophilic meningitis suggest that angiostrongylus cantonensis is present in reunion island. larvae of this nematode have been isolated after dissection of achatina fulica and have been used to infest laboratory rats. 30 days later, the dissection of these animals shows the presence of young worms in the brain and in the pulmonary arteries. 45 days later, first-stage larvae are recovered from the feces of animals. now, the strain is maintained in biomphalaria gla ...19761037434
angiostrongylus cantonensis in rats on makung, pescadores islands (peng hu). 19761037538
comparative studies on the life history of angiostrongylus mackerrasae bhaibulaya, 1968 and angiostrongylus cantonensis (chen, 1935). 19751112632
eosinophilic meningitis (angiostrongylosis): a probable case.a probable case of eosinophilic meningitis is described. this report is thought to be the first of a case of this disorder diagnosed in new south wales, although infection probably occurred in queensland. the life cycle of the parasite angiostrongylus cantonensis is outlined briefly and the clinical manifestations of this disease are discussed. treatment with thiabendazole seems to have been beneficial to this patient.19751143147
epidemiologic studies of eosinophilic meningitis in southern taiwan.a study of the epidemiologic characteristics of 125 cases of eosinophilic meningitis or meningoencephalitis, probably caused by angiostrongylus cantonensis, which occurred in southern taiwan in 1968 and 1969 revealed a close association of the disease with the rainy season. in contrast to findings in other geographic areas, most such cases in this study occurred among children. a higher attack rate was observed among aborigines than among descendants of mainland chinese. most patients had eaten ...19751155688
the encapsulation process in biomphalaria glabrata experimentally infected with the metastrongylid angiostrongylus cantonensis: light microscopy. 19751158554
animal model of human disease. central nervous system infection with the nematode angiostrongylus cantonenis. animal model: eosinophilic meningoencephalitis in mice infected with angiostrongylus cantonensis. 19751163634
the effect of some biological and physical factors on infection of biomphalaria glabrata with angiostrongylus cantonensis.several biological and physical factors which may influence infection of biomphalaria glabrata snails with the first stage larvae of angiostrongylus cantonensis were studied. these factors were: the size of snails, the number of first stage larvae to which snails were exposed, the age of larvae, individual exposure compared with mass exposure of snails, the length of exposure period and the effect of temperature and light. the results showed that young snails, 2 mm in diameter, became infected w ...19751189582
the suitability of several aquatic snails as intermediate hosts for angiostrongylus cantonensis.sixteen species of aquatic snails of four families were tested by quantitative technique under standardized conditions for their suitability as intermediate hosts for angiostrongylus cantonensis. these species were the planorbid snails biomphalaria glabrata, biomphalaria alexandrina, planorbis planorbis, planorbis intermixtus, bulinus truncatus, bulinus contortus, bulinus africanus, bulinus tropicus and helisoma sp.; the lymnaeid snails lymnaea natalensis, lymnaea tomentosa, lymnaea stagnalis, a ...19751189583
potential intermediate and paratenic hosts for angiostrongylus cantonensis. 19751195076
[larvicidial activity of anthelmintics against angiostrongylus cantonensis]. 19751200975
host-parasite relationship of angiostrongylus cantonensis in lymnaea palustris. ii. histopathology. 19761269582
host-parasite relationship of angiostrongylus cantonensis in lymnaea palustris. iii. oxygen uptake of lymnaea palustris. 19761269583
angiostrongylus cantonensis. 19921285777
seasonal intensity of angiostrongylus cantonensis in the intermediate host, laevicaulis alte.the slug, laevicaulis alte, is a vector of angiostrongylus cantonensis in the greater bombay area. the seasonal prevalence of a. cantonensis was investigated to determine the maximum intensity of the parasite in a field population occupying an area of approximately 400 m2. the maximum intensity of larvae was observed in the rainy months, june-november. investigations showed that individual l. alte could tolerate an infecting dose of 150 first-stage a. cantonensis larvae before mortalities occurr ...19921399252
in vitro effects of milbemycin oxime: mechanism of action against angiostrongylus cantonensis and dirofilaria immitis.the neuropharmacological mechanisms underlying the action of milbemycin oxime on the motility of angiostrongylus cantonensis and dirofilaria immitis were examined in vitro. in a. cantonensis, milbemycin oxime caused inhibitory effects at low concentrations of > or = 10(-9) g/ml, and paralysis was elicited at 10(-8) - 10(-6) g/ml. the paralysis was antagonized by picrotoxin and bicuculline but not by dibenamine. in addition, stimulatory effects were observed when the antibiotic was used at higher ...19921409536
[a case of eosinophilic meningitis due to angiostrongylus cantonensis].we report a case of eosinophilic meningitis caused by angiostrongylus cantonensis. this patient, a 50-year-old male, had been eating uncooked slugs for 40 years. his chief complaints on admission were headache, fever and general fatigue. neurological examination and ct findings were normal, but the csf contained increased cells, most of which were eosinophilic cells. the presence of eosinophilic cells in the csf is by itself abnormal. we therefore suspected eosinophilic meningitis and performed ...19921431377
[eosinophilic meningoencephalitis caused by angiostrongylus cantonensis: a case report (author's transl)]. 1978709966
angiostrongylus cantonensis infection in infants and young children. 19921461703
unusual manifestation of eosinophilic meningitis. 19921488715
experimental infection of yellow tree monitor (varanus bengalensis) and related species with angiostrongylus cantonensis. 19921523474
"commercially available, edible snails otala lactea (müller) and helix aperta (born) as laboratory hosts of angiostrongylus cantonensis". 1978627973
characterization of monoclonal antibodies to young-adult worms of angiostrongylus cantonensis.three igg1 and one igg2a monoclonal antibodies were obtained by fusion of ns-1 cells with spleen cells of balb/c mice immunized with young-adult worm antigen of a. cantonensis. these 4 monoclonal antibodies were specific to a. cantonensis without cross-reactivity to any antigens of toxocara canis, ascaris suum, clonorchis sinensis, dirofilaria immitis, paragonimus westermani, gnathostoma spinigerum, strongyloides stercoralis and anisakis spp. detected by elisa. the affinity constants of monoclon ...19901701759
eosinophilic meningitis beyond the pacific basin: the global dispersal of a peridomestic zoonosis caused by angiostrongylus cantonensis, the nematode lungworm of rats.the principal etiologic agent of human eosinophilic meningitis, angiostrongylus cantonensis, was first detected in rats in canton, china in 1933. the first human case was detected on taiwan in 1944. epidemic outbreaks were noted on ponape (e. caroline is.) from 1944 to 1948. the disease may present as transient meningitis or a more severe disease involving the brain, spinal cord and nerve roots, with a characteristic eosinophilia of the peripheral blood and csf. since 1961 it has been known that ...19921738873
experimental infection routes of angiostrongylus cantonensis in mice.stomach intubation is the most common method used in the experimental infection of animals with angiostrongylus cantonensis. in order to compare the effectiveness of other possible transmission methods, groups of balb/c mice were given infective third-stage larvae of a. cantonensis by different routes including intraperitoneal or subcutaneous injections, and penetration of anal mucosa, vaginal mucosa, conjunctival mucosa, lacerated skin, unabraded skin, foot pad and tail skin, while stomach intu ...19911795091
angiostrongylus cantonensis abscess in the brain. 19911800649
transmission of angiostrongylus cantonensis through the giant african snail achatina fulica: an experimental study.observations on transmission of the rat lung worm, angiostrongylus cantonensis, from rats to the snail intermediate host. achatina fulica, in a vacant lot in bangkok are described. the prevalence of a. cantonensis increased with snail age until 200 days of age when it attained a plateau of 50-60%. the overall prevalence was 53%. the worm burden slowly rose with age until 200 days of age beyond which it remained relatively constant. the highest mean worm burden of 5,478 was observed in the oldest ...19911822886
clinical manifestations of eosinophilic memingitis due to angiostrongylus cantonensis.between 1959 and 1976, 34 patients were seen in hawaii with eosinophilic meningitis. angiostrongylus cantonensis was recovered from two of these patients. the remaining cases were presumed to be due to this parasite because of clinical and epidemiologic findings. the most likely source of infection for eight patients was ingesting raw terrestrial snails or slugs, and for six patients eating raw or poorly cooked crustaceans. patients typically presented with severe headache; neck stiffness and fe ...1979574219
current status of food-borne parasitic zoonoses in taiwan.more than 50 species of zoonotic parasites (nematodes-18 spp., trematodes-19 spp., cestodes-10 spp., protozoa-2 spp., and arthropods-2 spp.) have been reported in taiwan. among them, angiostrongylus cantonensis, clonorchis sinensis and taenia saginata are the most important and most common food-borne parasites. angiostrongyliasis is highly endemic in southern and eastern taiwan. about 80% of patients are children below 15 years of age, mostly infected after eating achatina fulica during may and ...19911822939
nematode parasites of rats in west java, indonesia.from the indonesian rats, namely rattus rattus diardii, r. exulans, r. tiomanicus, r. niviventer, r. lepturus, r. bartelsii, r. cremoriventer, r. sabanus and pithecheir melanurus, surveyed for nematode parasites, the following parasites were recovered: angiostrongylus cantonensis, capillaria hepatica, cyclodontostomum purvisi, hepatojarakus malayae, rictularia tani, mastophorus muris, physaloptera sp. and subulura andersoni. of these, c. purvisi, h. malayae, physaloptera, sp. and s. andersoni ha ...1978571622
studies on susceptibility of pila ampullacea, to the infection with the rat lungworm, angiostrongylus cantonensis.experimental infections of pila ampullacea with first stage larvae of angiostrongylus cantonensis were carried out to determine susceptibility of this molluscan host in relation to dose level and snail host size. snails were divided into 3 size groups and exposed to a. cantonensis first stage larval suspensions of varying concentrations. the results showed that overall, about 20% of larvae ingested by the snails developed into infective third stage larvae, but the percentage was inversely relate ...1979538501
eosinophilic myelomeningoencephalitis caused by angiostrongylus cantonensis: a report of three cases.three members of a family developed eosinophilic myelomeningoencephalitis following ingestion of pila snails. they were father, daughter and son and had similar clinical presentations. two days after ingestion of snails, they developed a generalized itchy maculopapular rash followed by myalgia, marked paresthesia, fever and headache. two days later there was weakness of the extremities which was progressive in severity involving the legs more than the arms. they later developed urine retention a ...19911948289
equine neural angiostrongylosis.verminous encephalomyelitis due to angiostrongylus cantonensis larvae was diagnosed in 2 foals at necropsy. the principal clinical feature was tetraparesis, although history and neurological examination revealed progressive and multifocal neurological disease. at presentation, a tentative diagnosis of parasitic larval migration involving the central nervous system (cns), presumably due to strongylus vulgaris, was proposed. dissection of the spinal cord in one case resulted in recovery of intact ...19912025204
transplantation of young adult angiostrongylus cantonensis into the rat pulmonary vessels and its application to the assessment of acquired resistance. 1979437939
eosinophilic meningitis: a suspected case of angiostrongylosis found in shizuoka prefecture, honshu, japan.a patient with eosinophilic meningitis in shizuoka prefecture, honshu, japan had nausea, vomiting and headache on admission; laboratory examinations revealed leukocytosis with eosinophilia. eight days later neck stiffness appeared. lumbar puncture showed an increase of the initial pressure in association with eosinophilic pleocytosis in the spinal fluid. the possibility of angiostrongylosis was considered because the patient had eaten raw slugs for 4 years as a remedy for lumbago. although the s ...1979434313
migratory effects on the body surface of angiostrongylus cantonensis from subarachnoid space to pulmonary artery in rats.juvenile worms of angiostrongylus cantonensis recovered from subarachnoid spaces and pulmonary arteries of rats, respectively, at 28 days post-infection have been compared with respect to their surface composition, antigenicity of surface proteins and morphological appearance. quantitative and qualitative differences were shown between surface proteins of these two stages of worms. one major and 6 minor proteins appeared on brain stage worm's surface as assessed by surface-labelling and sds-page ...19902075491
[scanning electron microscopic observations on larvae and young adults of angiostrongylus cantonensis].scanning electron microscopic observations on the structure of the body surface of various larval stages and young adults of angiostrongylus cantonensis were made. the mouth opening of the first and second stage larvae closes in "y" form until well developed young adult stage. there are two rows of 6 sensory papillae each around the mouth. with development of the worm, the papillae of the outer row gradually degenerated and could hardly be seen in adult worms. a pair of amphidial pores was prese ...19902099261
de novo purine ribonucleotide biosynthesis in adult angiostrongylus cantonensis (nematoda: metastrongyloidea).1. radioactivity was found to be associated with purine ribonucleotides in extracts of gravid adult angiostrongylus cantonensis from the lungs of rats when the parasite was incubated in a medium containing [14c]glycine. 2. the rate of incorporation was at least 0.2 pmole/min per mg of parasite and approximately equal amounts of adenine and guanine ribonucleotides were synthesized. 3. this is the first demonstration of the capacity for a mammalian parasitic helminth to synthesize purines de novo.1979318440
immunoglobulin g-dependent classical complement pathway activation in neutrophil-mediated cytotoxicity to infective larvae of angiostrongylus cantonensis.the participation of antibody and complement in cell-mediated adherence and cytotoxicity to infected larvae (l3) of angiostrongylus cantonensis was investigated in vitro. of the different cell types involved in the reaction, neutrophils were seen to have a predominant role in immune serum--dependent adherence and cytotoxicity to l3. in the presence of immune serum, cytotoxicity to l3 by neutrophils from infected rats was twice that of neutrophils from normal rats. although mononuclear cells and ...19902200361
alteration in density of eosinophils in the cerebrospinal fluid of mice infected with angiostrongylus cantonensis.the density of eosinophils in the cerebrospinal fluid (csf) and blood of male ddy mice infected with angiostrongylus cantonensis was examined on days 14, 20 and 27 post-infection (p.i.) with discontinuous percoll gradient centrifugation. normal blood eosinophils had a density of between 1.070 and 1.080 g ml-1. no significant changes in density in blood eosinophils were noted during the course of the observations. csf eosinophils began to become hypodense (defined as density less than 1.070 g ml- ...19902228429
hexokinase of angiostrongylus cantonensis: presence of a glucokinase.1. angiostrongylus cantonensis contains a glucokinase which was isolated by deae-cellulose column chromatography. 2. this enzyme has a much higher affinity toward glucose (apparent km, 0.2 mm) than fructose (apparent km, 85 mm). glucose-6-phosphate (10 mm) does not inhibit glucose phosphorylation. 3. molecular weight obtained by a molecular sieve chromatography (60,000) is also close to the value of mammalian glucokinase. 4. while vmax value for mannose is one-third smaller than that for glucose ...1979318415
a survey of ampullarium canaliculatus for natural infection of angiostrongylus cantonensis in south taiwan.ampullarium canaliculatus were collected monthly from the field in five areas in pintung county and examined for larvae of angiostrongylus cantonensis. snails from one area showed the highest positive rate (30.8%) and the highest number (31) of larvae per snail. snails were placed in four groups according to size. the positive rates in snails increased from 10.0 to 29.4% and the average number of larvae per snail increased from 11 to 40 as the size of snails increased from 1.0 to 4.0 cm height o ...19902231842
acid phosphatase activity demonstrated by intact angiostrongylus cantonesis with special reference to its function.intact angiostrongylus cantonensis is able to hydrolyse glucose-phosphate esters, mononucleotides and rho-nitrophenyl phosphate as well as beta-glycerophosphate in vitro. reciprocal inhibition studies suggest that the hydrolysis of such substrates is due to a non-specific phosphomonoesterase. molybdate ions, which exert no effect on either the uptake of glucose or the production of lactate, inhibit the hydrolysis of glucose-1-phosphate in the external medium and simultaneously lower the producti ...197944361
the influence of mesocestoides corti on subsequent angiostrongylus cantonensis infections in mice.the influence of mesocestoides corti on subsequent angiostrongylus cantonensis infection in mice (c57bl/6 and balb/c) was assessed. both strains of mice infected with m. corti demonstrated a peak blood eosinophilia at around 3 weeks post-infection (p.i.). c57bl/6 and balb/c mice primarily infected with m. corti were given a. cantonensis infection 18 days later, but pre-existing m. corti infection did not affect the recovery of intracranial worms of a. cantonensis at day 21 p.i. balb/c mice with ...19921428507
precursors of pyrimidine nucleotide biosynthesis for gravid angiostrongylus cantonensis (nematoda: metastrongyloidea).gravid angiostrongylus cantonensis can utilize radiolabelled bicarbonate, orotate, uracil, uridine and cytidine but not cytosine, thymine and thymidine for the synthesis of rna and dna. in cell-free extracts of the worm, a phosphoribosyltransferase was shown to convert orotate to omp and uracil to ump. a similar reaction was not observed with cytosine and thymine. uridine was readily phosphorylated by a kinase but a similar reaction for thymidine and deoxyuridine was not found. cytidine could be ...19921379574
in vitro observation on egg release by angiostrongylus cantonensis from rats treated with flubendazole. 19921308258
higher sensitivity of the developing larvae of angiostrongylus cantonensis than the adult worms to flubendazole and mebendazole.two kinds of benzimidazoles, flubendazole and mebendazole were each administered at 10 mg/kg to rats harbouring the developing larvae of the rat lungworm, angiostrongylus cantonensis 3 or 10 days post-infection and to those harbouring the adult worms 70 days post-infection. almost all of the larvae were eliminated from the rats mediated 3 days post-infection. the larvicidal effects of the drugs administered 10 days post-infection were not so high as those 3 days post-infection. however, the grow ...19921308254
eosinophilic meningitis caused by angiostrongylus cantonensis. 19902367166
[experimental study on detection of serum antibodies by immunoenzyme staining using adult angiostrongylus cantonensis frozen section].this paper reported on the results of detection of serum antibodies in rats with angiostrongylus cantonensis infection by immunoenzyme staining of adult frozen section. the positive rates of serum antibodies in rats 2 and 4 weeks after infection were 80% and 93.3%, respectively. the result of healthy control rats was negative.19921307283
first record of angiostrongylus cantonensis (chen, 1935) (nematoda: metastrongylidae) in the dominican republic.rats, rattus norvegicus, trapped in some sections (barrios) of the city of santo domingo, the capital of the dominican republic showed that 5 of them from two barrios harbored the nematode angiostrongylus cantonensis in the pulmonary artery. macerated and digested terrestrial snails, subulina octona, collected from the backyards of houses where the rats were trapped contained l2 and l3 larvae of the nematode. the morphology of the adult worms and the larvae was consistent with that described for ...19921293731
characterization of monoclonal antibodies against eosinophil chemotactic factors from young adult worms of angiostrongylus cantonensis.two kinds of igg1 monoclonal antibodies against eosinophil chemotactic factors (ecfs) derived from angiostrongylus cantonensis young adult worms (ya) were established. western blot analyses demonstrated that one monoclonal antibody recognized a 16.1 kd component of ya-whole worm extract, and the other an 85 kd component. these antibodies did not show any cross reactions against several helminth antigens, as assessed by elisa. the chemotactic activity of ya-whole worm extract for guinea-pig-eosin ...19921281918
clinical observations on eosinophilic meningitis and meningoencephalitis caused by angiostrongylus cantonensis on taiwan.one hundred and twenty-five patients with eosinophilic meningitis or meningoencephalitis were studied in southern taiwan in 1968 and 1969. the majority of patients had mild to moderate disease, but several had severe manifestations. four patients died and three others had severe permanent sequelae such as blindness. young adult angiostrongylus cantonensis were recovered from nine patients, at autopsy in one, and from the cerebrospinal fluid of eight who survived. the clinical manifestations of c ...19761259085
isolation of specific antigens from angiostrongylus cantonensis. 2. by affinity chromatography.the crude adult worm extract of angiostrongylus cantonensis was subjected to a series of affinity chromatography for selective removal of host antigens as well as cross-reactive components with other helminths. the purified fraction designated as ac(p) with molecular weights ranging from 10,000-42,000 was found to contain antigenic components specific to a. cantonensis as determined by immunoelectrophoresis and enzyme-linked immunosorbent assay.19862428179
[intrathecal synthesis of immunoglobulins in meningoencephalitis caused by angiostrongylus cantonensis (chen, 1935)].four cases of eosinophil meningoencephalitis caused by angiostrongylus cantonensis are studied. the cytochemical study of the cerebrospinal fluid of these patients found a prevalence of eosinophils with increased ige. serum showed a variable behavior of immunoglobulins except for the increase of total ige. all patients showed igg and iga synthesis and there was igm synthesis in one patient. the percentage of intrathecal synthesis was variable and ige synthesis manifests in two trends with an equ ...19892486220
angiostrongylus cantonensis: lymphoid cell responsiveness and antibody production in rats.angiostrongylus cantonensis-infected rats were examined for the presence of antigen sensitive lymphocytes, as assessed by the in vitro uptake of tritiated thymidine by cells of various lymphoid organs (cervical, mediastinal and mesenteric lymph nodes, spleen and periphereal blood), following stimulation by adult worm antigen. the lymphoid cell response of rats to a. cantonensis appeared to be local in nature in that significant responses were noted only in the cervical lymph node cells during th ...19761259083
the first authentic record of angiostrongylus cantonensis chen, 1935 peninsular malaysia.angiostrongylus cantonensis chen, was recovered from a field rat, rattus tiomanicus from the east coast of peninsular malaysia. the parasite constitutes the first reported record occurring in this country. morphological character of the parasite are compared with the original description of a. cantonensis by chen (1935), a. cantonensis from formosa and a. malaysiensis from malaysia.19751221505
the encapsulation process in biomphalaria glabrata experimentally infected with the metastrongylid angiostrongylus cantonensis: enzyme histochemistry. 19751206232
eosinophilic meningitis in thailand. clinical studies of 484 typical cases probably caused by angiostrongylus cantonensis.six hundred and forty-six patients with an eosinophilic pleocytosis were studied in thailand over a 3-year period ending in march 1968. it was possible to segregate the cases into two clinical entities, which were termed typical eosinophilic meningitis and eosinophilic myeloencephalitis respectively. the clinical and laboratory finding of 484 cases of typical eosinophilic meningitis are reported here. the latter entity was generally benign and self-limited with a case mortality ratio of less tha ...19751200257
angiostrongylus cantonensis in the cerebrospinal fluid of an adult male patient with eosinophilic meningitis in thailand.a living, fifth-stage female angiostrongylus cantonensis 5 mm in length was discovered in the cerebrospinal fluid of a 21-year-old thai male with eosinophilic meningitis, the second such case to be recorded from thailand.19751155707
angiostrongyliasis cantonensis (eosinophilic meningitis, alicata's disease).angiostrongyliasis is an infectious disease caused by nematode parasites of the genus angiostrongylus. the rat lung worm angiostrongylus cantonensis, primarily a parasite of rodents, is largely responsible for human cases of eosinophilic meningitis, or meningoencerphalitis, which occurs on many pacific islands and in southeast asia. the disorder, which frequently occurs in epidemic extent, is caused by invasion of the central nervous system by developing larvae of the parasite. the infection is ...19751095293
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