| immunity to plasmodium berghei yoelii in mice. ii. specific and nonspecific cellular and humoral responses during the course of infection. | the kinetics of various specific and nonspecific immunologic responses were examined in balb/c mice infected with 17x nonlethal plasmodium berghei yoelii (a self-limiting infection). the sequence of events after infection was characterized by rapid sensitization of splenic t cells to malaria antigen and polyclonal b cell activation, followed by a period of depressed splenic proliferative responses in vitro to mitogens (pha and lps) and malaria (specific) antigen. at the same time, suppressed pri ... | 1978 | 79610 |
| immunity to plasmodium berghei yoelii in mice. i. the course of infection in t cell and b cell deficient mice. | the course of infection with 17x nonlethal plasmodium berghei yoelii was examined in balb/c mice which were deficient in either t cells or b cells. markedly increased parasitemia and mortality were observed in athymic (nude) mice which had been backcrossed on a balb/c background (t cell deficient) compared to similar mice which had been grafted with neonatal balb/c thymus, and were also observed in balb/c mice suppressed from birth with goat antiserum to mouse mu-chain (b cell deficient) compare ... | 1976 | 136472 |
| sarcomas induced by injection of simian virus 40 into neonatal cfw mice. | sarcomas were induced in cfw mice by the iv inoculation of simian virus 40 (sv40) in neonatal animals. infection with murine malaria parasites, plasmodium berghei yoelli, decreased the latency and increased the incidence and invasiveness of the tumors. all mice given both sv40 and p. berghei yoelli had sarcomas of the liver and spleen at 9 months of age. at 11 months of age, 70% of the sv40-inoculated mice had sarcomas of the liver indistinguishable from those in the group given both pathogens. ... | 1979 | 225503 |
| delayed immune reactions in mice immunized with malarial antigen. | mice were immunized subcutaneously, intravenously or in a footpad with antigens prepared from a lethal strain of plasmodium berghei yoelii. a delayed footpad swelling (dfs) reaction was observed 4 days after immunization, and was detectable at least 42 days after immunization. however, iv immunization was the least efficacious is producing hypersensitivity. regardless of the type of antigen used for immunization, mice responded similarly when live parasites were used to elicit dfs. this study re ... | 1977 | 326066 |
| the immunological response of cba mice to p. yoelii. i. general characteristics, the effects of t-cell deprivation and reconstitution with thymus grafts. | experimental infection of normal cba mice with the parasite plasmodium berghei yoelii (p. yoelii) resulted in a mild, non-fatal and self-limiting infection which lasted for 15-17 days. animals which recovered from the primary infection were immune to reinfection though parasites could be detected in the kidneys of such mice 4 weeks after recovery from infection. (no plasmodia were demonstrated in the peripheral blood and other tissues examined.) in t cell-deprived mice, p. yoelii infections resu ... | 1977 | 328382 |
| prevention of recrudescent malaria in nude mice by thymic grafting or by treatment with hyperimmune serum. | nude mice died when infected with the normally avirulent malarial parasite plasmodium berghei yoelii. furthermore, malaria recrudesced in nu/nu mice after the termination of acute disease by treatment with clindamycin. recrudescence was not observed in nu/nu mice that had been grafted with thymic tissue or treated with hyperimmune serum. mice mad b cell deficient by treatment with anti-mu-chain serum also died when infected with p. berghei yoelii. the data suggest that a crucial role of the thym ... | 1977 | 330396 |
| the immunological response of cba mice to p. yoelii. ii. the passive transfer of immunity with serum and cells. | cba mice infected with the malaria parasite plasmodium berghei yoelii (p. yoelii) develop a self-resolving infection lasting 15-18 days; on recovery from a primary infection they are immune to further infection. cell and serum transfers from immune to non-immune mice were used to analyse the mechanism of resistance. whereas serum from mice which had recovered from a single infection was ineffective in transferring immunity, hyperimmune serum (from mice repeatedly challenged with p. yoelii) prote ... | 1978 | 342396 |
| [alteration in the virulence of plasmodium berghei yoelii for white mice by passage through golden hamsters and by the in vitro exposure to the serum of these animals]. | | 1978 | 355826 |
| proceedings: the passive transfer of immunity to plasmodium berghei yoelii. | | 1975 | 766319 |
| an in vitro assay for t cell immunity to malaria in mice. | after infection with a nonlethal strain of murine malaria (17xnl plasmodium berghei yoelli), balb/c mice are then resistant to a lethal strain (17xl p.b. yoelli). balb/c mice were infected with 17xnl, anc challenged 3 weeks later, after clearing their parasitemias, with 17xl. three weeks thereafter, spleen cells from such immune animals were used to define an early peaking t-dependent (anti-theta sensitive) antigen-specific proliferative response when incubated in vitro with 17xl infected rbc, o ... | 1976 | 774978 |
| chronic malarial infection in balb/c mice. effect on the immune response to sheep erythrocytes and histological changes in the liver and spleen. | chronic malarial infection was established in balb/c mice by following plasmodium berghei yoelii with p.b. berghei infection. it was found that the igg plaque-forming cell response to sheep erythrocytes was depressed for at least six months. a preliminary investigation of the histological changes in the spleen and liver is described. the possibility that chronically infected mice could serve as a model for the tropical splenomegaly syndrome is discussed. | 1975 | 779156 |
| interaction between trypanosoma brucei and plasmodium berghei in concurrent infections in mice. | in conccurrent infection of trypanosoma brucei rhodesiense and plasmodium berghei yoelii in mice, potentiation of one parasite by the other was observed, especially the malaria by the trypanosome infection. the effect appeared early in the infection. it is suggested that the mutual potentiation of the two infections was probably due to immuno-suppression which both organisms are capable of inducing in the host. | 1976 | 789909 |
| malarial immunodepression in vitro: adherent spleen cells are functionally defective as accessory cells in the response to horse erythrocytes. | the basis for the depressed response of malarial infected mice to horse red blood cells (hrbc) has been studied in vitro. results presented show that the adherent spleen cells from infected mice (a) are defective in their ability to allow nonadherent spleen cells of both normal and infected mice to respond to hrbc whereas a response does occur with adherent spleen cells from normal mice (b) do not suppress the response of unfractionated spleen cells from normal mice to hrbc (c) contain phagocyti ... | 1976 | 793851 |
| mouse malaria nephropathy. | mice were infected with 1x 107 plasmodium berghei yoelii parasites intraperitoneally. circulating parasite, malaria antibody and c3 concentrations were measures: parasitaemia and hypocomplementaemia were transient, but the antibody response was persistent. animals were sacrificed at intervals and their kidneys examined: a glomerulonephritis associates with predominantly mesangial deposits of c3, igg1, igm and some iga always developed after 7 days and persisted for up to 6 mth. malaria antigen a ... | 1976 | 796419 |
| [increased non-specific resistance to induction of malaria by sporozoites of plasmodium berghei yoëlii in mice pretreated with a bacterial phospholipid extract]. | the injection of a bacterial phosphospholipid extract increases resistance of mice subsequently challenged with sporozoïtes of plasmodium berghei yoëlii. the pretreatment consisted of one injection of a suspension containing various amounts of phospholipid extract. it was e-fective when it shortly preceded the sporozoïtes inoculation. this resulted in total protection of a great number of animals against various amounts of sporozoïtes. there was a correlation between the dose of ebp injected and ... | 1975 | 819147 |
| regional immunosuppression induced by plasmodium berghei yoelii infection in mice. | plasmodium berghei yoelii infection in mice severely depressed the splenic antibody response to sheep erythrocytes but had lettle effect on antibody formation in lymph nodes. | 1975 | 1090525 |
| anaemia in mice with concomitant schistosoma mansoni and plasmodium berghei yoelii infection. | 1. the effect on anaemia in mice given plasmodium berghei yoelii 3 and 5 weeks after exposure to schistosoma mansoni cercariae, was investigated. 2. haematological criteria (pcv and haemoglobin levels), reticulocytosis, parasitaemia and splenomegaly were used as indices. 3. anaemia was severe in the animals given p. b. yoelii and in those with mixed infection (p. b: yoelii plus s. mansoni). malaria was found to dominate the picture until the clearance of the parasitaemia. the effect of the inter ... | 1975 | 1096378 |
| sudden increase in virulence in a strain of plasmodium berghei yoelii. | the mild and chronic 17x strain of plasmodium berghei yoelii showed a sudden increase in virulence following a period of 110 days in the deep freeze. the enhanced virulence was seen in a very high and early parasite peak in the blood and a 100% mortality of all infected mice. the exalted virulence remained unaltered following a number of blood transfers of the strain and after four cyclical transmissions through anopheles stephensi. enzyme pattern studies revealed that the virulent strain posses ... | 1975 | 1098585 |
| immunological studies in rodent malaria. i: protective immunity induced in mice by mild strains of plasmodium berghei yoelii against a virulent and fatal line of this plasmodium. | mild and virulent lines of plasmodium berghei yoelii are readily distinguished both by their course of infection and by the preference of the virulent line for mature red blood cells. mice given either mild line were fully protected against the virulent p.b. yoelii one week after they had become negative. mice given the mild line of p.b. yoelii 17x were fully protected against a challenge by the virulent line on the third day of infection (d+3). mice given the mild and virulent lines of p.b. yoe ... | 1975 | 1098589 |
| chloroquine resistance in malaria: variations of substrate-stimulated chloroquine accumulation. | the response of [14c]chloroquine accumulation to the provision of substrate was evaluated using washed erythrocytes infected with plasmodium berghei cs (chloroquine-susceptible), with p. berghei cr (chloroquine-resistant), with plasmodium vinckei cs, with p. vinckei cr, or with a strain of p. berghei spontaneously resistant to chloroquine, plasmodium berghei yoelii 17x. erythrocytes infected with chloroquine-resistant parasites had a blunted response, particularly to low glucose concentrations. ... | 1975 | 1104805 |
| monoterpenic fragment analogues of aplasmomycin as potential antimalarial. | seven analogues of monoterpenic fragment of aplasmomycin were synthesized as targeted antimalarial agents. the potency of the compound 6 was comparable with the sesquiterpene lactone artemisinin and the antibiotic aplasmomycin in vivo against plasmodium berghei yoelli. | 1991 | 1895301 |
| activities of the tetrahydrofuran derivative, ba-41,799, against plasmodium cynomolgi infections in rhesus monkeys. | ba-41,799, a tetrahydrofuran derivative that at one time attracted considerable interest as an antimalarial agent because of a combination of structural novelty with activities against infections with plasmodium berghei and plasmodium berghei yoelii in mice, has been evaluated for its capacities to effect prophylaxis and radical cure in rhesus monkeys challenged or already infected with sporozoites of the drug-susceptible ro strain or the pyrimethamine-resistant ro/pm strain of plasmodium cynomo ... | 1985 | 3985599 |
| 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues as potential antimalarial agents. | five 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues were synthesized and tested for radical curative activity against plasmodium cynomolgi in rhesus monkeys and for blood schizonticidal antimalarial activity against plasmodium berghei in mice. in addition, they were evaluated for causal prophylactic antimalarial activity against plasmodium berghei yoelii in mice. one compound, 4-ethyl-5-[m-(trifluoromethyl)phenoxy]primaquine (2b), showed radical curative activity equivalent to ... | 1985 | 4067985 |
| sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine as potential antimalarial agents. | two isomeric sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine (2) were prepared and tested for antimalarial activity. the compounds were evaluated for blood schizonticidal activity against plasmodium berghei in mice and radical curative activity against plasmodium cynomolgi in rhesus monkeys. in addition, they were evaluated for causal prophylactic activity against plasmodium berghei yoelii in mice. both compounds were more active and less toxi ... | 1985 | 4068013 |
| antibody levels in mice infectedwith plasmodium berghei yoelii. | | 1970 | 4099406 |
| assessment of causal prophylactic activity in plasmodium berghei yoelii and its value for the development of new antimalarial drugs. | the causal prophylactic activity of several reference and experimental antimalarial compounds was assessed in sporozoite-induced infections of nmri mice with plasmodium berghei yoelii (strain 17x). the animals were inoculated with 10 000 sporozoites per mouse and treated once 2-4 hours later. the test system has proved to be very suitable in experiments involving more than 3 000 mice. the infection rate in 448 untreated controls was 97.3%. lowering the sporozoite content of the inoculum to 1 000 ... | 1974 | 4155355 |
| influence of plasmodium berghei yoelii or p. chabaudi or both on the course of splenomegaly and immunoglobulins in mice. | | 1969 | 4186077 |
| inhibition of the immune response to pertussis vaccine during plasmodium berghei yoelii infection in mice. | mice infected with plasmodium berghei yoelii responded poorly to pertussis vaccine when administered at peak parasitemia. this was shown by serum agglutinin titers and lack of protection against intracerebral challenge with virulent bordetella pertussis. | 1974 | 4375413 |
| effect of paba on chloroquine resistance in plasmodium berghei yoelii. | | 1972 | 4557790 |
| a cytoplasmic polyhedrosis virus in midgut cells of anopheles stephensi and in the sporogonic stages of plasmodium berghei yoelii. | although it has been known for some time that nuclear and cytoplasmic polyhedrosis viruses may infect the larval stages of mosquitos capable of transmitting mammalian malaria this paper reports for the first time the presence of a cytoplasmic polyhedrosis virus in adult anopheles stephensi. the virus was shown to be present in sporogonic stages of plasmodium berghei yoelii with which the mosquitos were infected. it is possible that other viruses may affect both vector and malaria parasites. furt ... | 1972 | 4557906 |
| a comparative account of the effects of betamethasone on mice infected with plasmodium vinckei chabaudi and plasmodium berghei yoelii. | | 1974 | 4592839 |
| brain capillary blockage produced by a virulent strain of rodent malaria. | a sudden enhancement in virulence of a mild plasmodium berghei yoelii 17 x strain resulted in fulminating and fatal infections in cf1 and a/j mice. the virulent strain has maintained its characteristics after ten cyclical transmissions through anopheles stephensi. the visible expression of virulence of the mutated strain is its ability to cross the blood-brain barrier and cause intravascular sequestration of injected erythrocytes and blockage of brain capillaries. we, therfore, believe that the ... | 1974 | 4595458 |
| babesia microti and plasmodium berghei yoelii infections in nude mice. | | 1974 | 4610411 |
| [immunodepression vis-a-vis anti-whooping cough vaccine in mice infested with plasmodium berghei yoelii]. | | 1972 | 4620615 |
| studies of splenomegaly in rodent malaria. 3. protein calorie malnutrition and splenomegaly in mice infected with plasmodium berghei yoelii. | | 1972 | 4625993 |
| studies of splenomegaly in rodent malaria. ii. the course of splenomegaly, igm, igg levels and igg immunofluorescent antibody titre in mice after infection with plasmodium berghei yoelii and-or plasmodium chabaudi. | | 1971 | 4938408 |
| [experimental reproduction of delayed hepatic schizonts of plasmodium berghei yoelii in the liver of a steatomys (dendromurinaea)]. | | 1970 | 4994197 |
| [causal preventive activity of standard antimalarials in rodent malaria (plasmodium berghei yoelii)]. | | 1972 | 5050530 |
| separation of genetically distinct lines from a recently isolated strain of plasmodium berghei yoelii. | | 1972 | 5071068 |
| effect of paba and sulphadiazine on two pyrimethamine-resistant plasmodium berghei yoelii lines. | | 1972 | 5071069 |
| acquired immunity to plasmodium berghei yoelii in mice. | | 1971 | 5159136 |
| [the course of malarial infection, caused by different strains of plasmodium berghei yoelii landau and killick-kendrick, 1966]. | | 1969 | 5396563 |
| electron microscope studies on motile stages of malaria parasites. vi. the oökinete of plasmodium berghei yoelii and its transformation into the early oöcyst. | | 1969 | 5794450 |
| studies of splenomegaly in rodent malaria. i. the course of splenomegaly in mice infected with eperythrozoon coccoides, plasmodium berghei yoelii and the two infections combined. | | 1969 | 5819326 |
| [study of the cycle of plasmodium berghei yoelii in view of the massive production of viable sporozoites and exo-erythrocytary forms]. | | 1966 | 5991608 |
| enhanced parasitization of platelets by plasmodium berghei yoelii. | in previous studies plasmodia have been found by electron microscopy within human platelets naturally infected with plasmodium vivax and within platelets of mice infected intraperitoneally with p. berghei. in both situations the number of parasitized platelets was low. an enhancement of platelet parasitization was attempted in order to study in greater detail the mechanisms and implications of such a phenomenon. various in vitro incubation mixtures of normal mouse platelets and free merozoites o ... | 1984 | 6485052 |
| protection against plasmodium berghei yoelii in chloroquine- and pyrimethamine-treated mice. | the antimalarial drugs chloroquine and pyrimethamine were observed to afford protection to mice treated with these agents. this protection was observed in mice when given a subsequent challenge infection after they had been radically cured of p. b. yoelii infection. | 1984 | 6510839 |
| [immunosuppressive response to antidiphtheria vaccine in animals infected by plasmodium berghei yoëlii]. | | 1980 | 6927588 |
| [immunosuppressive response to antitetanus vaccine in mice infected with plasmodium berghei yoëlii]. | | 1980 | 6927589 |
| [effect of adjuvants on the immunosuppressive effect of the parasitic action of plasmodium berghei yoëlii]. | | 1980 | 6927590 |
| experimental transmission of murine malaria by the oral route. | a total of 116 young male cd1 mice were orally inoculated with mouse blood; half of the animals received 0.2 ml of uninfected blood and the others were given 0.2 ml of plasmodium berghei yoelii-infected blood in six experiments performed at different times. almost 30% of the experimental mice acquired malaria as demonstrated by the observation of parasites in their blood. in no case were parasites found in the blood of control mice. rodent malaria parasites may be transmitted to cd1 mice by the ... | 1993 | 8415572 |
| in vitro and in vivo antiplasmodial activity of cryptolepine and related alkaloids from cryptolepis sanguinolenta. | three different extracts and four alkaloids from the root bark of cryptolepis sanguinolenta have been assessed in vitro against plasmodium falciparum d-6 (chloroquine-sensitive strain), k-1, and w-2 (chloroquine-resistant strains). cryptolepine (1) and its hydrochloride (2), 11-hydroxycryptolepine (3), and neocryptolepine (5) showed a strong antiplasmodial activity against p. falciparum chloroquine-resistant strains. quindoline (4) was less active. the highest activity was obtained with compound ... | 1997 | 9249972 |
| in vivo antimalarial activity of leaves of plectranthus amboinicus (lour) spreng on plasmodium berghei yoelii. | an invivo study of aqueous extract of the leaves of plectranthus amboinicus on plasmodium berghei yoelii was conducted on laboratory infected albino mice and compared with standard drug chloroquine. reduction of parasitemia at 250 mg/kg and 500 mg/kg of aqueous extract for 24 hrs, 48 hrs, 72 hrs and 96 hrs were determined. the reduction of parasitemia after 96 hrs was 100%, 67.9% and 76.2% for standard, 250 mg/kg and 500 mg/kg of aqueous extract respectively. the isolation of active principle re ... | 2008 | 19301696 |