| [dna-, rna-, lipidsynthesis and the specific activity of the glucose-6-phosphate dehydrogenase and glucose-6-phosphatase in the different morphologic stages of plasmodium vinckei]. | dna-, rna-, and lipidsynthesis, glucose-6-phosphate-dehydrogenase, glucose-6-phosphatase and succinate-dehydrogenase were studied in the different morphologic stages of blood schizogony of plasmodium vinckei. for the separation of these stages of the maturation cycle a discontinuous ficoll-density gradient was developed. by this method the morphologic stages were separated and obtained in sufficient amounts. dna-, rna- and lipidsynthesis was not continuous in the intraerythrocytic cycle of the p ... | 1975 | 167481 |
| protection of mice against babesia spp. and plasmodium spp. with killed corynebacterium parvum. | mice which had been pre-treated with killed corynebacterium parvum given intravenously or intraperitoneally, but not subcutaneously, were completely resistant to infection with babesia microti or b. rodhaini, and were protected from death caused by plasmodium vinckei or p. chabaudi infection. there is evidence that the parasites died within circulating erythrocytes. this occurred much too soon for a specific antibody response to be evoked, and no antibody could be detected by the indirect fluore ... | 1977 | 320544 |
| plasmodium yoelii and plasmodium vinckei: the effects of nonspecific immunostimulation on murine malaria. | | 1977 | 330190 |
| [further observations of the course of plasmodium berghei infection in the mouse]. | invasion of immature and mature erythrocytes by merozoites of plasmodium berghei seems to obey the following rules: merozoites prefer unparasitized immature erythrocytes. multiple infections of immature erythrocytes occur in conditions of high merozoite production and low concentration of unparasitized immature erythrocytes, when frequently repeated contacts between merozoites and unparasitized or freshly parasitized immature erythrocytes become increasingly probable. mature erythrocytes are inv ... | 1979 | 375509 |
| resistance to babesia spp. and plasmodium sp. in mice pretreated with an extract of coxiella burnetii. | mice injected intravenously with a commercially available extract of coxiella burnetii prepared for use as the antigen in the complement fixation diagnostic test for q fever were subsequently resistant to infection with babesia microti, babesia rodhaini, and plasmodium vinckei petteri. the parasites appeared to die inside circulating erythrocytes. protection was unaffected by exposing the pretreated mice to 900 rads on the day before they were infected. to explain these findings, it is postulate ... | 1979 | 378850 |
| free-flow electrophoresis for the separation of malaria infected and uninfected mouse erythrocytes and for the isolation of free parasites (plasmodium vinckei): a new rapid technique for the liberation of malaria parasites from their host cells. | after aggregation of erythrocytes from malaria infected mice, the parasites (plasmodium vinckei) could be set free using gentle mechanical forces. the mixture of freed parasites, infected and non-infected erythrocytes, and membraneous material was separated by free-flow electrophoresis. the free parasites produced were very pure and infectious. morphological and enzymatic data on the separated fractions are presented. free-flow electrophoresis also allowed the separation of infected and uninfect ... | 1979 | 433382 |
| heterologous immunity between piroplasms and malaria parasites: the simultaneous elimination of plasmodium vinckei and babesia microti from the blood of doubly infected mice. | mice which have recovered from infections with the avirulent piroplasm babesia microti are also resistant to challenge with the virulent malaria parasite plasmodium vinckei. in mice infected with p. vinckei before the peak of the b. microti infection the numbers of malaria parasites in the blood increase until that peak and are then eliminated at the same time as the piroplasms. in mice infected with p. vinckei at or after the peak there is no apparent multiplication and the malaria parasites be ... | 1978 | 622306 |
| malaria parasites of rodents of the congo (brazzaville): plasmodium chabaudi adami subsp. nov. and plasmodium vinckei lentum landau, michel, adam and boulard, 1970. | descriptions are given of the blood forms, sporogonic stages and enzyme forms of plasmodium chabaudi adami subsp.-nov. and p. vinckei lentum, malaria parasites of the thicket-rat thamnomys rutilans of the brazzaville region. the two species differ from each other in both morphological and enzymic characters. p.c. adami and p. v. lentum differ from the other subspecies of p. chabaudi and p. vinckei principally by their enzyme forms. | 1976 | 800328 |
| chloroquine resistance in malaria: variations of substrate-stimulated chloroquine accumulation. | the response of [14c]chloroquine accumulation to the provision of substrate was evaluated using washed erythrocytes infected with plasmodium berghei cs (chloroquine-susceptible), with p. berghei cr (chloroquine-resistant), with plasmodium vinckei cs, with p. vinckei cr, or with a strain of p. berghei spontaneously resistant to chloroquine, plasmodium berghei yoelii 17x. erythrocytes infected with chloroquine-resistant parasites had a blunted response, particularly to low glucose concentrations. ... | 1975 | 1104805 |
| new observations on the malaria parasites of rodents of the central african republic - plasmodium vinckei petteri subsp. nov. and plasmodium chabaudi landau, 1965. | the morphology and enzyme forms of malaria parasites isolated from 50 wild caught specimens of thamnomys rutilans from the central african republic have been studied and three distinct species of plasmodium identified. one species has been confirmed as plasmodium yoelii yoelii. morphological features of both the remaining species correspond to those given by landau (1965) in her original description of plasmodium chabaudi. for one of these species the name p. chabaudi has been retained; the othe ... | 1975 | 1155987 |
| growth in vitro and metabolism of plasmodium vinckei chabaudi. | an in vitro system, based on the rocker dilution technic, has been developed that supports intraerythrocytic growth of a rat-adapted strain of plasmodium vinckei chabaudi from ring to schizont stages; some reinvasion was obtained, although invariably, this was associated with a decrease in parasite numbers. pertinent features were the very high buffer content of the medium and the low oxygen tension of the gaseous phase. lactate production, glucose utilization, and 3h-leucine and 3h-adenosine in ... | 1975 | 1195158 |
| parasitic protozoa of the blood of rodents. v. plasmodium vinckei brucechwatti subsp. nov. a malaria parasite of the thicket rat, thamnomys rutilans, in nigeria. | a description is given of the blood stages of a new subspecies of plasmodium vinckei in the blood of naturally infected thicket rats (thamnomys rutilans) from nigeria and experimentally infected mice. sporogony was obtained at 25 degrees c in anopheles stephensi a. quadrimaculatus and a.l. atroparvus, but sporozoites in the salivary glands of the mosquitoes were never infective. the new parasite is differentiated from 7 other species of malaria parasites of african rodents principally on the mor ... | 1975 | 1211764 |
| [glutathionestatus of plasmodium vinckei parasitized erythrocytes in correlation to the intraerythrocytic development of the parasite (author's transl)]. | the glutathione status of plasmodium vinckei parasitized erythrocytes of mice was determined in correlation to the intraerythrocytic stage of maturation of the parasite. the different stages of blood schizogony were separated by discontinuous dextran-density-centrifugation. the changes of protein content, glutathione concentration (reduced/oxidized and bound/free glutathione) and in the specific activities of the following enzymes: gamma-glutamyl-cysteine-synthetase (gc-synthetase), glutathione- ... | 1975 | 1216329 |
| [influence of xanthine oxidase on duration of asexual cycle of plasmodium vinckei in the mouse (author's transl)]. | injection of 1.2 u xanthine oxidase in plasmodium vinckei-infected mice showing high parasitemias prolonged the duration of the asexual cycle by about 10% and slightly decreased the multiplication factor of the parasites. this appears to be of theoretical interest only since the rapid and fatal course of the infection remained essentially unaltered. | 1976 | 1258145 |
| [involvement of cellular immunity in pathology. neuromalaria]. | murin cerebral malaria (mcm) with plasmodium berghei anka and the cba/ca mice is the result of an immunopathological process. an overproduction of tnf is implicated in its pathogenesis. recent datas concerning tnf production during the course of plasmodium vinckei vinckei infection, and analysis of relationships between mcm and experimental allergic encephalomyelitis (eae) raise the hypothesis of the involvement of an auto-immune process in the murin disease. the role of cellular immunity in hum ... | 1992 | 1327351 |
| interferon-gamma induced lethality in the late phase of plasmodium vinckei malaria despite effective parasite clearance by chloroquine. | a combination therapy was tested consisting of chloroquine and interferon-gamma (ifn-gamma) in the late phase of blood-stage plasmodium vinckei malaria in balb/c mice. when mice were treated with three times 300 micrograms chloroquine at 24-h intervals starting at a parasitemia of 30%-50%, only 5 of 14 mice (36%) died 2-4 days after initiation of therapy. however, when infected mice received chloroquine plus 1 microgram ifn-gamma at the same time, 14 of 18 mice (78%) died 0.5-3 days after start ... | 1992 | 1425913 |
| the in vitro and in vivo antimalarial activity of some mannich bases derived from 4-(7'-trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol, 2-(7'-trifluoromethyl-quinolin-4'-ylamino)phenol, and 4'-chloro-5-(7''-trifluoromethylquinolin-4''-ylamino)biphenyl -2-ols. | a series of di-mannich base derivatives (4 and 5) from 4-(7'-trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol and 2-(7'-trifluoromethylquinolin-4'-ylamino)phenol, respectively, and mono-mannich base derivatives (6) from 4'-chloro-5-(7''-trifluoromethylquinolin-4''- ylamino)biphenyl-2-ol were assayed for activity against the chloroquine-sensitive (fcq-27) isolate of cultured plasmodium falciparum using the inhibition of uptake of radiolabelled hypoxanthine. all seven di-mannich base derivativ ... | 1992 | 1463352 |
| antibody response in plasmodium vinckei malaria after treatment with chloroquine and adjuvant interferon-gamma. | the antibody response of mice infected with plasmodium vinckei after treatment with chloroquine either alone or in combination with interferon-gamma (ifn-gamma) was determined. sequential serum samples were drawn from balb/c mice receiving either 240 micrograms chloroquine on the day of infection or 120 micrograms chloroquine plus 10(4) units ifn-gamma daily for 11 days beginning on day 3 prior to infection. mice treated with additional ifn-gamma showed an early induction of igg2a response and a ... | 1992 | 1480597 |
| plasmodium vinckei petteri: identification of the stages sensitive to arteether. | antimalarial activity of arteether, a derivative of artemisinin (qinghaosu) against blood-induced infections of the highly synchronous plasmodium vinckei petteri rodent species of malaria was evaluated in swiss mice. a single subcurative dose of arteether of 2.2 mg/kg body weight was injected subcutaneously to mice, either during the prepatent period or during the patent infection, when different stages of the parasitic cycle were present in the blood. it was shown that rings and young trophozoi ... | 1992 | 1493877 |
| inability of plasmodium vinckei-immune spleen cells to transfer protection to recipient mice exposed to vaccine 'vectors' or heterologous species of plasmodium. | mice can be immunized to plasmodium vinckei by repeated infections followed by cure. such immunity is dependent on cd4 t cells and an architecturally modified spleen, but has little requirement for antibody. thus, athymic mice can be exposed to p. vinckei and cured, but do not develop immunity. they are resistant to challenge with parasites, however, if they are then given spleen cells from euthymic immunized animals. such immune spleen cells, however, cannot transfer resistance to normal mice w ... | 1991 | 1683480 |
| coagulation disorders in experimentally induced acute mouse malaria. | the development of coagulation disorders was studied in murine malaria. plasmodium vinckei was chosen following an initial experiment because onset and duration of parasitemia were more suitable for hemostasiological studies than in the short-lasting infection, caused by p. berghei. evaluation of the time courses of hematocrit, platelets, antithrombin (at) iii activity, factor v activity and parasitemia showed a significant decrease in platelets, hematocrit, factor v and at iii activity during t ... | 1991 | 1686145 |
| [plasmodium vinckei petteri: various aspects of its sporogony and exoerythrocytic schizogony]. | a study of plasmodium vinckei peterri sporogony was performed by experimental infection of anopheles stephensi with gametocytes from infected mice. the study includes the description of the ookinete, complete evolution of oocysts and their final transformation to sporozoites. these were later used for intravenous infection of new mice, in order to study the exoerythrocytic schizogony. the morphology of exoerythrocytic schizonts was similar to that of other species of the same group. the minimal ... | 1991 | 1844972 |
| chronotherapy of malaria: identification of drug-sensitive stage of parasite and timing of drug delivery for improved therapy. | the cyclic nature of malarial fever in conjunction with the pharmacokinetic characteristics of antimalarial drugs, call for the conception of a chrono-therapeutic approach for the treatment of the disease. an experimental murine malarial model was devised using the highly synchronous species plasmodium vinckei petteri to test this rationale. sub-curative doses of chloroquine were injected sub-cutaneously to mice either during the prepatent period or during patent infection. inspection of the eff ... | 1991 | 1883151 |
| interferon-gamma enhances the effect of antimalarial chemotherapy in murine plasmodium vinckei malaria. | most nonimmune patients with plasmodium falciparum infection are no longer cured by such standard antimalarial drugs as chloroquine. thus, alternative treatment regimens are necessary. a combination therapy was tested consisting of a subcurative dose of chloroquine and interferon-gamma (ifn-gamma) in balb/c mice with lethal plasmodium vinckei malaria. treatment with either agent alone prolonged median survival by 1-2 days compared with placebo-treated mice. however, a combination of 80 microgram ... | 1991 | 1902249 |
| immunization of mice against plasmodium vinckei with a combination of attenuated salmonella typhimurium and malarial antigen. | infection with the blood stage of the malaria parasite plasmodium vinckei is uniformly lethal in mice. we found that immunization of balb/c mice with a combination of killed p. vinckei antigens and an attenuated (aroa) salmonella typhimurium strain induces high levels of protection against challenge with live p. vinckei. this is especially significant because, in our previous studies, immunization of mice with killed p. vinckei antigens and adjuvants such as bordetella pertussis, complete freund ... | 1990 | 1976114 |
| cellular mechanisms in immunity to blood stage infection. | we studied mechanisms of immunity to blood stage infection in the mouse malarias plasmodium vinckei and plasmodium yoelii 17x. infection with p. vinckei was uniformly lethal, whereas p. yoelii 17x caused a self-limited, nonlethal infection. transfer of immune cd4+ t cells conferred protection against p. yoelii in nude mice. previous studies by others had suggested that immunity to p. yoelii may be related to mhc class i expression on reticulocytes and found that cd8+ t cells alone transferred pr ... | 1990 | 1980907 |
| flavins as potential antimalarials. 2. 3-methyl-10-(substituted-phenyl) flavins. | a series of 3-methyl-10-(substituted-phenyl)flavins was prepared and tested for antimalarial activity against the lethal parasite plasmodium vinckei in mice. several of these analogues were found to be effective antimalarial agents. a quantitative structure-activity relationship study was undertaken with 44 analogues and no satisfactory relationship could be established. | 1991 | 2061923 |
| antimalarial action of flavin analogues seems not be due to inhibition of glutathione reductase of host erythrocytes. | a series of 10-(4'-chlorophenyl)-3-substituted flavins (1a-f) were examined with respect to their antimalarial properties. they were tested against plasmodium falciparum in vitro and plasmodium vinckei vinckei in vivo. the proposition that they might act through glutathione reductase (gr) (ec 1.6.4.2) inhibition has been studied. inhibition of p. falciparum in vitro by these compounds shows only slight variation between analogues; in contrast, inhibition of human erythrocyte gr by members of the ... | 1990 | 2182031 |
| tnf and plasmodium berghei anka-induced cerebral malaria. | the cerebral pathology observed in plasmodium berghei anka-infected cba mice has been attributed to overproduction of tnf, the mice in which this syndrome is seen being those with the highest serum tnf levels. to investigate this further, we injected recombinant human tnf into malaria-primed mice to see if we could reproduce the cerebral changes observed in p. berghei anka infections. a range of doses, administered as a single or repeated injections, or via osmotic pumps, failed to reproduce the ... | 1990 | 2283149 |
| role of dna-binding antibodies in kidney pathology associated with murine malaria infections. | we performed a series of studies to examine the sequential development of nephritis during murine malaria infections and to define the role of dna-binding antibodies in the associated pathology. serum levels of these antibodies were assessed throughout acute and chronic malaria infections. increased levels of double-stranded dna- and single-stranded dna-binding antibodies were initially detected in mice infected with plasmodium vinckei or plasmodium yoelii nigeriensis during the middle stages of ... | 1990 | 2365456 |
| resolution of acute malarial infections by t cell-dependent non-antibody-mediated mechanisms of immunity. | while it is generally accepted that acute blood stage malarial infections are resolved through the actions of protective antibodies, we observed that resistance to acute infection with plasmodium chabaudi adami was mediated by t cell-dependent cellular immune mechanisms independent of antibody. we now report that acute blood stage infections caused by three additional murine hemoprotozoan parasites, plasmodium vinckei petteri, plasmodium chabaudi chabaudi, and babesia microti, appear to be contr ... | 1990 | 2387628 |
| bleomycin-detectable iron in plasma from plasmodium vinckei vinckei-infected mice. | plasma from mice heavily parasitized by plasmodium vinckei vinckei was found to contain micromolar levels of iron as detected by the 'bleomycin assay' (slightly modified) of gutteridge et al. [(1981) biochem. j. 199, 263-265]. uninfected mouse plasma contained little or no bleomycin-detectable iron. plasma ultrafiltrate from infected mice contained no bleomycin-detectable iron, indicating that such iron was associated with the protein/macromolecule fraction. we speculate that this iron could cat ... | 1986 | 2417884 |
| interdependence of cd4+ t cells and malarial spleen in immunity to plasmodium vinckei vinckei. relevance to vaccine development. | we studied immunity to the blood stage of the rodent malaria, plasmodium vinckei vinckei, which is uniformly lethal to mice. balb/c mice develop solid immunity after two infections and drug cure. the following experiments define the basis of this immunity. transfer of pooled serum from such immune mice renders very limited protection to balb/c mice and no protection to athymic nu/nu mice. moreover, b cell-deficient c3h/hen mice develop immunity to p. vinckei reinfection in the same manner as imm ... | 1989 | 2570802 |
| application of anti-tnf to plasmodium vinckei-infected mice is followed by an increase of parasitaemia. | | 1989 | 2571256 |
| molecular karyotyping of the rodent malarias plasmodium chabaudi, plasmodium berghei and plasmodium vinckei. | the molecular karyotypes of four isolates of plasmodium chabaudi, three of the subspecies p. chabaudi adami and one p. chabaudi chabaudi, as well as p. berghei and p. vinckei were studied by means of pulsed field gradient (pfg) gel electrophoresis. each species appears to have 14 chromosomes, ranging in size from approximately 730 kb to greater than 2000 kb. the three p. chabaudi adami isolates did not appear any more similar to each other than to the p. c. chabaudi isolate. the chromosome locat ... | 1989 | 2651917 |
| in vitro and in vivo activities of atalaphillinine and related acridone alkaloids against rodent malaria. | thirty acridone alkaloids obtained from citrus, glycosmis, or severinia plants (members of the family rutaceae) were tested for their antimalarial activities in vitro and in vivo. at a concentration of 10 micrograms/ml in vitro, seven of these alkaloids suppressed 90% or more of plasmodium yoelii, which causes malaria in rodents. atalaphillinine, when injected intraperitoneally in a daily dose of 50 mg/kg for 3 days into mice infected with 10(7) erythrocytes parasitized with plasmodium berghei o ... | 1989 | 2653215 |
| inhibition of plasmodium vinckei-malaria in mice by recombinant murine interferon-gamma. | | 1988 | 2903630 |
| experimental modifications of the circadian rythm of plasmodium vinckei petteri following cryopreservation; probable resistance of the merozoïte to thawing. | plasmodium vinckei petteri, in white mice, is a particularly useful strain for studies on the circadian rythm of plasmodium. an experimental model was set up: it showed that the rythm of asexual schizogony in the blood varies with the time and the mode of inoculation (cryopreserved blood or syringe passage). when frozen blood is injected, the time of schizogony depends on the time of injection; on the contrary, when the passage is by syringe from mouse to mouse, the rythm of schizogony is the sa ... | 1988 | 3142640 |
| tumor necrosis factor in malaria-induced abortion. | the cause of fetal loss in malaria is not known. we report that a small (1.5-5.0 micrograms) intravenous dose of recombinant human tumor necrosis factor (tnf) caused fetal death and abortion in 16 day pregnant mice that were carrying low densities of plasmodium vinckei. in contrast, 50 micrograms human tnf did not cause fetal death or abortion in uninfected 16 day pregnant mice. endogenous tnf, which was not detectable in plasma of low parasitemia animals, pregnant or not, was present (1.6 +/- 0 ... | 1988 | 3177738 |
| tumour necrosis factor may contribute to the anaemia of malaria by causing dyserythropoiesis and erythrophagocytosis. | among the unexplained changes caused by malaria in several host species, including man and mouse, are erythrophagocytosis and dyserythropoiesis. in order to see whether tumour necrosis factor (tnf) could contribute to these changes we injected recombinant human tnf intravenously into mice made very susceptible to this monokine by low density infection with a mouse malaria (plasmodium vinckei) or prior injection of an extract of coxiella burneti. appreciable erythrophagocytosis, involving nucleat ... | 1988 | 3179231 |
| detection of short-chain carbonyl products of lipid peroxidation from malaria-parasite (plasmodium vinckei)-infected red blood cells exposed to oxidative stress. | reversed-phase h.p.l.c. was used to detect 2,4-dinitrophenylhydrazine-reactive carbonyl products, which excludes malonaldehyde, in malaria-parasite (plasmodium vinckei)-infected murine red blood cells (rbcs). a number of alkanals, 4-hydroxyalk-2-enals and alka-2,4-dienals were tentatively identified by comparison with authentic standards. the formation of 4-hydroxynon-2-enal, deca-2,4-dienal and hexanal was greater in p. vinckei-infected rbcs than in their uninfected counterparts and was increas ... | 1988 | 3342016 |
| increased production of arachidonate metabolites by peritoneal cells of mice infected with plasmodium vinckei vinckei. | peritoneal cells from mice infected with plasmodium vinckei vinckei generate about four times more prostaglandin f and 6-keto prostaglandin f1 alpha, five times the prostaglandin e and ten times the thromboxane b2 than do peritoneal cells from normal mice. these results were not due to differences in the ratios of cell subpopulations from each group. as well as providing additional evidence that macrophage activation occurs in malaria, the increased production of these prostanoids could help exp ... | 1986 | 3579736 |
| possible roles of tumor necrosis factor in the pathology of malaria. | the authors have earlier proposed that tumor necrosis factor (tnf) might contribute to the pathology of malaria. here they report the outcome of injecting recombinant human tnf/cachectin into normal mice and others with low parasitemias (6-35%) of plasmodium vinckei. the object was to see how precisely the pathologic features of the terminal stages of this infection could be produced, when parasitemias are 70-80%. hypoglycemia, mid-zonal liver damage, and pulmonary accumulation of neutrophils in ... | 1987 | 3661678 |
| antimalarial activity of a riboflavin analog against plasmodium vinckei in vivo and plasmodium falciparum in vitro. | the riboflavin analog 10-(4'-chlorophenyl)-3-methylflavin was found to have significant activity against plasmodium vinckei vinckei when administered orally and parenterally; it was active against p. falciparum in culture. it inhibited mouse erythrocyte glutathione reductase in a dose-dependent manner. when administered orally, 5-deazariboflavin was not active in vivo although it has been shown to have activity against p. falciparum in vitro. | 1987 | 3688306 |
| possible mechanisms responsible for the increased ascorbic acid content of plasmodium vinckei-infected mouse erythrocytes. | the possible mechanisms underlying the acquisition of an increased ascorbic acid content by mouse erythrocytes containing the malarial parasite plasmodium vinckei were investigated. ascorbic acid was taken up readily by parasitized red blood cells but not by controls, whilst its partly oxidized form, dehydroascorbic acid, entered both. the uptake of both ascorbic acid and dehydroascorbic acid into erythrocytes was increased as a result of malarial infection. lysates prepared from parasitized red ... | 1986 | 3697376 |
| injection of free radical generators causes premature onset of tissue damage in malaria-infected mice. | lymphoid and liver damage does not usually occur in plasmodium vinckei-infected mice until parasitaemias reach 70-80 per cent and the mice are showing signs of illness. we report here that these changes can be induced in mice of healthy appearance and lower parasitaemia by injecting divicine or tertiary-butyl hydroperoxide, two generators of free oxygen radicals. the same or larger doses of these radical generators did not induce this tissue damage in normal mice. phagocytic leukocytes are activ ... | 1986 | 3701495 |
| murine malaria decreases hemopoietic stem cells. | the causes of anemia and immunosuppression, major outcomes of malaria, are not well established. this study was undertaken to investigate whether erythropoietin (ep) production is adequate and whether the hemopoietic stem cells (cfu-s) were affected during the course of infection. groups of female balb/c mice infected with plasmodium vinckei vinckei, plasmodium berghei, or plasmodium chabaudi adami were exposed to five hours of simulated altitude equivalent to 22,000 ft. plasma samples were coll ... | 1987 | 3801660 |
| lipids from plasmodium vinckei-infected erythrocytes and their susceptibility to oxidative damage. | the constituent lipids of plasma and red blood cells (rbc) from mice late in infection with the malarial parasite plasmodium vinckei were analyzed and compared with those obtained from uninfected animals. on a dry weight basis, the total extractable lipids of rbc increased threefold during infection, while those of the plasma did not change significantly. in general, changes in individual plasma lipid constituents paralleled those found in rbc of infected mice but were of smaller magnitude. whil ... | 1987 | 3821401 |
| oxidative stress and protective mechanisms in erythrocytes in relation to plasmodium vinckei load. | the protection of mouse erythrocytes (rbc) parasitized with plasmodium vinckei vinckei against activated oxygen species was examined in relation to the intraerythrocytic parasite load. rbc from highly infected animals were separated by density gradient centrifugation into six bands with increasing parasite content and with parasitemias ranging from 17% to 100%. increase in parasite load was accompanied by a decrease in the activities of the enzymes superoxide dismutase (ec 1.15.1.1), catalase (e ... | 1985 | 3855565 |
| antioxidants in plasma from mice infected with plasmodium vinckei. | the late stage of infection of mice with the malarial parasite plasmodium vinckei was accompanied by significant changes in the content of most antioxidants within plasma. the plasma concentrations of uric acid and vitamin c increased, in contrast to those of vitamin e and total plasma proteins, whilst the activity of superoxide dismutase did not change significantly. in contrast to the situation within erythrocytes, the ratio of partly oxidized forms of vitamin c (dehydroascorbate and diketogul ... | 1986 | 3947322 |
| protection of vitamin e from oxidation by increased ascorbic acid content within plasmodium vinckei-infected erythrocytes. | erythrocytes isolated from mice at a late stage of infection with the malarial parasite plasmodium vinckei contained increased levels of vitamin e, but neither control nor infected erythrocytes contained detectable levels of alpha-tocopherolquinone, an oxidation product of vitamin e. total levels of the antioxidant, vitamin c, were more than doubled in the same populations of highly parasitized erythrocytes. these observations, and the lower ratio of oxidized to reduced forms of ascorbic acid in ... | 1986 | 3955068 |
| plasmodium vinckei: suppression of mouse infections with desferrioxamine b. | plasmodium vinckei kills nmri mice within 6 days after infection. treatment of infected animals with desferrioxamine b for 5 days was found to suppress the parasitemia in a dose-dependent manner. the desferrioxamine b-iron complex (dfo/fe3+) was ineffective, which suggests that the iron-chelating capacity of free desferrioxamine b is the antimalarial principle. all mice survived when they were given 0.3 mg desferrioxamine b/g every 12 hr for 14 days after infection. in addition, they were resist ... | 1985 | 4029347 |
| the asexual and sexual circadian rhythms of plasmodium vinckei chabaudi, of p. berghei and of p. gallinaceum. | | 1972 | 4156397 |
| fluorescent antibody levels in mice infected with plasmodium vinckei and p. chabaudi. | | 1969 | 4186078 |
| the biology of rodent malaria with particular reference to plasmodium vinckei vinckei rodhain 1952. | | 1971 | 4398609 |
| [influence of allopurinol on length of asexual cycle and multiplication rate of plasmodium vinckei in the rat (author's transl)]. | | 1974 | 4446069 |
| a comparative account of the effects of betamethasone on mice infected with plasmodium vinckei chabaudi and plasmodium berghei yoelii. | | 1974 | 4592839 |
| enzyme variation in plasmodium berghei and plasmodium vinckei. | | 1973 | 4595114 |
| [antimetabolites of folic acid metabolism with chemotherapeutic activity against rodent malaria (plasmodium vinckei)]. | | 1973 | 4778588 |
| [derivatives of pyrimidine and purine as antimetabolites in the metabolism of plasmodia (plasmodium vinckei) (author's transl)]. | | 1974 | 4839006 |
| [age distribution and developmental stages of plasmodium vinckei populations]. | | 1968 | 4878203 |
| [nucleic acid metabolism in experimental malaria. 2. incorporation of adenosine and hypoxanthine into the nucleic acids of malaria parasites (plasmodium berghei and plasmodium vinckei)]. | | 1968 | 4878204 |
| antibody levels detected by the fluorescent antibody technique in mice infected with plasmodium vinckei and p. chabaudi. | the malaria parasites of mice are convenient models for immunological studies. plasmodium vinckei and p. chabaudi are similar parasites which behave differently in mice, the former invariably being fatal whereas the latter seldom kills the host. the experiments described in this paper were performed in order to compare the antibody levels in the ig, igm and igg serum fractions in mice cured of p. vinckei infections and naturally recovered from p. chabaudi. the technique involved using specific l ... | 1969 | 4905148 |
| [nucleic acid metabolism in experimental malaria. 3. the utilization of adenine from the adenine-nucleotide pool of the erythrocytes for the synthesis of nucleic acids in malaria parasites (plasmodium vinckei) in vivo]. | | 1969 | 4909005 |
| studies on the protective effect of plasmodium chabaudi infection in mice upon a subsequent infection with another rodent malaria species, plasmodium vinckei. | | 1966 | 4957831 |
| [the multiplication rate of plasmodium berghei, plasmodium vinckei and babesia rodhaini]. | | 1967 | 4972587 |
| [elimination of eperythrozoon coccoides from strains of babesia rodhaini, plasmodium berghei and plasmodium vinckei]. | | 1968 | 4974248 |
| quantitative cytochemistry of malaria infected erythrocytes (plasmodium berghei, plasmodium chabaudi and plasmodium vinckei). | | 1969 | 4987018 |
| induction of growth and division synchrony in plasmodium vinckei chabaudi by photoperiodic rhythm. | | 1972 | 5012513 |
| [criteria for the selection of sulfonamides for the treatment of rodent malaria (plasmodium vinckei)]. | | 1972 | 5050535 |
| synchronization of growth and division of rat-adapted plasmodium vinckei chabaudi by photoperiodic rhythm. | | 1971 | 5159148 |
| [effectiveness of trypanocides berenil and pentamidine in rodent malaria (plasmodium vinckei)]. | | 1971 | 5167439 |
| plasmodium chabaudi and plasmodium vinckei: phagocytic activity of mouse reticuloendothelial system. | | 1969 | 5362592 |
| [standardization of plasmodium vinckei infections in nmri mice]. | | 1969 | 5393814 |
| plasmodium vinckei: production of chloroquine-resistant strain. | | 1969 | 5401455 |
| the fine structure of the oocysts of plasmodium vinckei. | | 1970 | 5442088 |
| the course of simultaneously inoculated, concomitant infections with plasmodium vinckei and plasmodium berghei in white mice. | | 1970 | 5449052 |
| a study of inapparent infections of plasmodium vinckei in the adult hamster (mesocricetus auratus). | | 1970 | 5449053 |
| altered dihydrofolate reductase associated with drug-resistance transfer between rodent plasmodia. | resistance to pyrimethamine in strains of plasmodium vinckei and of plasmodium berghei is attributed to changes in amounts and properties of the dihydrofolate reductases. the resistant strain of plasmodium berghei was isolated from an experimentally induced mixed infection of drug-resistant plasmodium vinckei and drug-sensitive plasmodium berghei, through biological filtration in hamsters. the drug resistance in plasmodium berghei appears to have been acquired through transfer of part of the gen ... | 1970 | 5460847 |
| [the behavior of plasmodium vinckei in the mouse and its influencing by leishmania-donovani infection]. | | 1970 | 5473456 |
| serological changes during the acquisition of immunity to plasmodium vinckei in mice. | | 1970 | 5485710 |
| the life cycle of plasmodium vinckei lentum subsp. nov. in the laboratory; comments on the nomenclature of the murine malaria parasites. | | 1970 | 5500105 |
| [new 6-aminoquinolines with antimalarial activity. test results on schizontocidal and causalprophylactic effects in rodent- and avian malaria (plasmodium vinckei, p. berghei and p. cathemerium)]. | | 1970 | 5536991 |
| the effect of reticulocytosis on plasmodium vinckei infection in white mice. action of phenylhydrazine and of repeated bleedings. | | 1971 | 5548319 |
| [nucleic acid metabolism in experimental malaria. 1. studies on the incorporation of thymidine, uridine, and adenosine in the malaria parasite (plasmodium berghei and plasmodium vinckei)]. | | 1967 | 5613460 |
| [the cyclic transmission of plasmodium vinckei]. | | 1967 | 5629913 |
| primary exo-erythrocytic forms of plasmodium vinckei. | | 1968 | 5643108 |
| the fine structure of plasmodium vinckei, a malaria parasite of rodents. | | 1968 | 5679815 |
| an electron microscopic examination of erythrocytic stages of two rodent malarial parasites, plasmodium chabaudi and plasmodium vinckei. | | 1968 | 5687765 |
| the effect of betamethasone on acquired immunity to plasmodium vinckei in mice. | | 1968 | 5714957 |
| [synchronized populations of plasmodium vinckei]. | | 1968 | 5715370 |
| [incorporation of exogenous adenosine and hypoxanthine in the nucleic acids of malaria parasites (plasmodium berghei and plasmodium vinckei)]. | | 1968 | 5719577 |
| [ultrastructure and biology of plasmodium vinckei, rodhain 1952. i. absorption and digestion of hemoglobin in trophozoites]. | | 1968 | 5757923 |
| the stein and desowitz haemagglutination test for the detection of antibodies to plasmodium berghei and plasmodium vinckei. | | 1965 | 5855032 |
| gametogenesis of plasmodium vinckei. | | 1965 | 5870332 |
| transfer of antibodies to plasmodium vinckei through milk of immune mice. | | 1965 | 5893811 |
| observations on the gametogenesis of plasmodium vinckei. | | 1966 | 5967845 |
| pinocytosis in plasmodium vinckei. | | 1966 | 5971130 |
| acquired immunity to plasmodium vinckei in mice. | | 1966 | 5971586 |
| the induction of tyrosine aminotransferase activity and its use as an indirect assay for endotoxin in mice infected with plasmodium vinckei petteri. | | 1982 | 6126456 |