mycetoma in somalia - results of a survey done from 1959 to 1964.the pasteur institute studied 103 mycetoma patients in somalia between 1959 and 1964. grains were seen in 94 of them and this, added to cultural features, allowed the diagnosis of 60 pathogens as follows: 44 madurella mycetomi, 1 leptosphaeria senegalensis, 7 pyrenochaeta romeroi (or madurella grisea), 3 allescheria boydii, 1 fusarium sp., 3 neotestudina (zopfia) rosatii, and 1 unidentified; 34 were actinomycetes: 24 streptomyces somaliensis, 4 actinomadura madurae, 3 a. pelletieri and 3 nocardi ...197723657
comparative virulence and immunodiffusion analysis of petriellidium boydii (shear) malloch strains isolated from feedlot manure and a human mycetoma.the virulence to mice of a petriellidium boydii strain isolated from feedlot manure was compared with that of a strain from a human mycetoma. washed spores suspended in 5% hog gastric mucin were injected intraperitoneally into non-inbred female albino swiss mice. in 21 days, the mycetoma strain killed 95% of the test animals whereas injection of eight times as many feedlot strain spores resulted in only 28% mortality. a progressive, exclusively sinistral (leftsided) torticollis was the most obvi ...197898224
keratitis and endophthalmitis caused by petriellidium boydii.a 26-year-old man sustained burns of the left eye and eyelids from molten aluminum. antimicrobial and anti-inflammatory therapy was instituted. cultures of conjunctival material collected 14 days after the burn grew abundant colonies of petriellidium boydii. because of severe pain and impending corneal perforation, the eye was enucleated.1977299985
disseminated petriellidosis (allescheriosis).disseminated infection by petriellidium (allescheria) boydii occurred in an immunosuppressed renal allograft recipient. a probable airborne pulmonary infection underwent hematogenous spread to the brain, thyroid, and heart. the organism develops septate, branching hyphae in tissue and may be misdiagnosed as aspergillus. the basic pathologic lesions are necrosis with a predominantly polymorphonuclear leukocytic reaction and abscess formation, and a mild granulomatous response with macrophages and ...1978345997
[morphological and biological properties of allescheria boydii]. 1979425697
petriellidium boydii (allescheria boydii) endocarditis associated with porcine valve replacement. 1977562707
serological diagnosis of petriellidiosis (allescheriosis). ii. indirect (passive) hemagglutination assay for antibody to polysaccharide antigens of pertriellidium (allescheria) boydii and monosporium apiospermum. 1977563976
[immunochemistry of petriellidium boydii and immune response of rabbits, immunized with petriellidines (author's transl)]. 1978567597
[pulmonary allescheriosis (author's transl)].in a patient properly treated for a previous cavitary tuberculosis, we had the surprise, after hemoptyses, to find a sleigh-bell shaped picture suggesting an intra-cavitary aspergilloma with a very special mycosis with allescheria boydii. proof was provided by the presence of the fungus in direct examination and in culture in bronchial secretions. surgical exeresis did not cure the patient and a secondary recurrence appeared on which antifungal drugs were ineffective. antigens were made from the ...1979572967
in vitro studies with ambruticin, a new antifungal antibiotic.the in vitro antifungal inhibitory activities of ambruticin and of various antifungal drugs of choice against 190 fungal pathogens representative of the major human mycoses were compared using a modification of the ics agar dilution technique. ambruticin compared favorably with amphotericin b and miconazole when tested against the dimorphic pathogens coccidioides immitis, histoplasma capsulatum, and blastomyces dermatitidis and against aspergillus fumigatus. miconazole was the most active compou ...1978686712
in vitro comparison of the antifungal activities of r34,000, miconazole and amphotericin vitro susceptibilities of 78 isolates of pathogenic filamentous fungi to the imidazole compounds r34,000 and miconazole and to amphotericin b were determined using an agar dilution technique. allescheria boydii, sporothrix schenckii and the dematiaceous fungi (cladosporium, fonsecaea and phialophora spp.) were most susceptible to miconazole with minimum inhibitory concentration (mic) values ranging from less than or equal to 0.25 to 32 microgram/ml and with geometric mean mic (g-mic) values o ...1978699677
the relative susceptibility of new zealand black and cba mice to infection with opportunistic fungal pathogens.the susceptibility of ageing new zealand black (nzb) mice to infection with a number of opportunistic fungi and yeasts wsd compared with that of similarly aged mice of the cba strain. the nzb mice showed a greater susceptibility to lethal infection with aspergillus fumigatus, candida albicans and cryptococcus neoformans than did those of the cba strain. both mouse strains showed similar susceptibility to lethal infection by allescheria boydii, absidia corymbifera, mucor pusillus and rhizopus ory ...1976772839
counterimmunoelectrophoresis as a routine mycoserological procedure.counterimmunoelectrophoresis (cie) has been compared in a diangostic laboratory with agar gel double diffusion (dd) as a routine procedure for detection of antibodies to pathogenic and allergenic fungi and actinomycetes. it was shown to be of particular value in detecting antibodies to aspergillus fumigatus. thus 72 of 106 sera in which precipitins were detected were positive by cie alone. some sera were positive only by cie to antigens prepared from histoplasma capsulatum, allescheria boydii, c ...1975813146
occurrence of histoplasma capsulatum darling, 1906 in israel, with a review of the current status of histoplasmosis in the middle east.the isolation of histoplasma capsulatum from a bat cave in the galilee region of israel is reported along with the discovery of a bat (myotis myotis) infected by h. capsulatum. soils collected in avian and chiropteran habitats throughout israel also yielded the following fungi of medical interest: arthroderma quadrifidum, a. tuberculatum, candida parapsilosis, chrysosporium indicum, c. keratinophilum, c. tropicum, cryptococcus neoformans, ctenomyces serratus, microsporum gypseum, and petriellidi ...1977842775
allescheria (petriellidium) boydii sinusitis in a compromised host.the first case of allescheria (petriellidium) boydii sinusitis is reported. the organism was isolated from the maxillary sinus in an elderly, diabetic, chronic alcoholic man on maintenance hemodialysis who developed a syndrome resembling mucormycosis. infections with a. boydii are infrequent and are most commonly limited to madura foot. in addition, several cases of pulmonary and central nervous system involvement have been described. there is no established therapy for a. boydii, since the publ ...1977870522
the development in beef cattle manure of petriedllidium boydii (shear) malloch, a potential pathogen for man and cattle.petriellidium boydii (allescheria boydii) dominated the mycoflora of manure samples form three beef cattle feedlots after incubation at room temperature for 4 months. the possible dangers associated with this pathogenic fungus, which causes mycotic abortion in livestock, pulmonary allescheriasis in man, and mycetomas in both man and animals, are discussed. this fungus could create a health hazard in feedlots where in situ manure decompostion is encouraged.1976944082
visceral fungal infections due to petriellidium boydii (allescheria boydii). in vitro drug sensitivity studies.four patients with visceral infections due to the fungus petriellidium boydii, who were recently hospitalized in our institutions, are described. three of the patients were compromised hosts; in the fourth patient, infection occurred after trauma. all had received prior steroid and antibiotic therapy. studies of patients with mycetoma or secondary infection of a pulmonary cavity due to this organism and of patients with visceral infections are reviewed. because of histologic similarities to aspe ...1976984066
mycetoma in iran.the subject of mycetoma is reviewed and 7 cases are reported for the first time from southern iran. four were causes by actinomyces israelii and one each by nocardia asteroides, actinomadura madurae and allescheria boydii.19751092627
mycotic flora in the lower digestive tract of feral pigeons (columba livia) in the el paso, texas area.fourteen species of fungus were isolated from the lower digestive tract of 39 of 80 pigeons. sixteen pigeons had concurrent isolations while two harbored three species. fungi isolated were allescheria boydii, aspergillus spp., candida krusei, chrysosporium spp., geotrichum candidum, mucor spp., paeciliomyces spp., penicillium spp., rhizopus spp., rhodotorula spp., scopulariopsis spp., streptomyces spp., and trichosporon cutaneum. there was no apparent evidence that these fungi were associated wi ...19761255918
treatment failure in a case of fungal keratitis caused by pseudallescheria boydii.a case is presented of pseudallescheria boydii fungal keratitis in an agricultural welder. treatment with azole antifungal drugs (miconazole and itraconazole) and with penetrating keratoplasty was unsuccessful in eradicating the infection, and eventually the eye was eviscerated.19921320401
fungal pseudoallescheria boydii lung infiltrates unresponsive to amphotericin b in leukaemic patients.the management of patients with acute leukaemia is often complicated by serious fungal infections, especially of the lungs. the outcome of therapy has historically depended on the early use, efficacy and toxicity of amphotericin b. pseudoallescheria boydii is an uncommon cause of such infections but as it is more often resistant to amphotericin b early identification may enable the prompt use of alternative and newer antifungal agents. here we report our experience and review the literature in t ...19921323256
effects of culture media on the in vitro susceptibility of selected opportunistic fungi to fluconazole and itraconazole.the sensitivity of 23 isolates of opportunistic fungi, aspergillus fumigatus (5), a. flavus (5), a. niger (5), pseudallescheria boydii (5), alternaria alternata (2) and xylohypha bantiana (1), was investigated against fluconazole and itraconazole, using sabouraud's dextrose broth (sd) and a high-resolution (hr) medium (pfizer, inc.). the procedure followed was a standard tube dilution (1 ml/tube) method. candida albicans y01 09 was included as reference strain to monitor quality and reproducibil ...19921324830
acute pyogenic pseudallescheria boydii foot infection sequentially treated with miconazole and itraconazole. 19921335468
convergence in ascospore discharge mechanism among pyrenomycete fungi based on 18s ribosomal rna gene sequence.fungi of the class pyrenomycetes (ascomycotina) form a morphological series ranging from those that shoot ascospores (sexual spores) forcibly from the ascus (spore sac) to fungi that ooze ascospores or have no obvious mechanism for ascospore release. did forcible ascospore discharge evolve within these pyrenomycetes, or has it been lost in the group? we determined the sequences of the 18s ribosomal rna gene from three fungi and used these, along with six sequences from our previous work and thre ...19921342925
immunohistologic diagnosis of systemic mycoses: an update.fluorescent antibody, immunoperoxidase and gold-silver staining methods for the rapid and accurate diagnosis of systemic mycotic infections are currently performed in a few specialized laboratories. these methods have proved applicable to formalin-fixed, paraffin-embedded tissues, and are reliable for identifying therein antigens of infectious dimorphic, monomorphic filamentous, and yeast-like fungal pathogens, i.e., aspergillus spp., blastomyces dermatitidis, candida spp., coccidioides immitis, ...19921397200
pseudallescheria boydii endocarditis of the pulmonic valve in a liver transplant recipient.we describe a case of pseudallescheria boydii endocarditis involving the pulmonic valve in an orthotopic liver transplant recipient. the patient required transplantation because of hepatic failure secondary to chronic active hepatitis b. his postoperative course was complicated by surgery for gastric and duodenal ulcers, persistent fever, and, ultimately, sepsis leading to oliguric renal failure. two days before death, the patient experienced complete heart block, and an echocardiogram revealed ...19921445984
pseudallescheria boydii keratitis.we treated a case of post-traumatic keratitis caused by the soil saprophyte, pseudallescheria boydii. the injury was caused by a wood splinter which produced a perforating corneal laceration that was primarily repaired. signs of corneal infection were not evident until the fourth postoperative week. the organism was eradicated by topical miconazole and natamycin. subsequent penetrating keratoplasty combined with cataract extraction and intraocular lens implantation has achieved a good visual out ...19921449780
cyclosporine interactions with miconazole and other azole-antimycotics: a case report and review of the literature.several antimicrobial drugs have been shown to pharmacokinetically interact with cyclosporine. on two separate occasions, we observed increases in cyclosporine plasma concentrations during concomitant miconazole therapy in a heart transplant patient with an infection secondary to pseudallescheria boydii. to our knowledge, no interaction between cyclosporine and miconazole has previously been reported. in addition, drug interactions were observed between cyclosporine and ketoconazole and possibly ...19921457436
mycotic keratitis: a study in coastal karnataka.fungi were isolated from 67 cases out of the 295 cases of corneal ulcers investigated. aspergillus species and species of candida were the major fungal members isolated. allescheria boydii was isolated from 3 cases, having no previous history of injury to the eye or infection with bacterial or viral agents. a boydii corneal infection is a rare occurrence. higher incidence of mystic keratitis was seen among females than males. no relationship to seasonal changes could be established. bacterial in ...19921464454
pulmonary mycetomas in immunocompetent patients: diagnosis by fine-needle aspiration.mycetomas usually grow within preexisting cavities and frequently lead to pulmonary hemorrhage. we describe four males, aged 38 to 72 years, in whom myceotomas were diagnosed by fna. preexisting cavitary lesions resulted from tuberculosis, anaerobic abscess, and bullous lung disease (two cases). fine needle aspiration yielded tangled mats of fungal hyphae (large and grossly visible in three cases) and acute inflammatory cells. the atypical cells often seen in the walls of such lesions were not i ...19921468333
approaches to management of fungal infections in cancer patients.the patient most susceptible to invasive aspergillosis has had prolonged granulocytopenia resulting from intensive chemotherapy and/or radiation therapy, aplastic anemia, or acute leukemia. the sinuses and lungs are usually involved, but the infection may disseminate to the endocardium, skin, cns, and eye. efficacy of antifungal treatment with amphotericin b depends on early recognition and aggressive intervention. in severe or refractory cases, addition of flucytosine, rifampin, or fluconazole ...19921534671
pseudallescheria boydii keratomycosis in a dog.a dog that had a chronic history of keratoconjunctivitis sicca and was being treated topically with antibiotics and corticosteroids was examined for evaluation of a melting corneal ulcer. cytologic examination and cultures revealed the pathogen to be pseudallescheria boydii, a saprophytic fungus. the eye was surgically removed and evaluated histologically. fungal keratitis is rarely reported in dogs, but needs to be considered in refractory infections or in dogs treated with antibiotics or corti ...19921559876
invasive sinusitis due to pseudallescheria boydii in an immunocompetent host.chronic invasive sinusitis with pseudallescheria boydii as the etiologic agent is uncommon but occurs in immunocompetent hosts. we have presented the fourth documented case of sinusitis due to p boydii in a patient without other medical problems. pseudallescheria is generally sensitive to ketoconazole and not amphotericin b in therapeutic levels. in vitro culture and sensitivity studies are essential in selecting the appropriate antibiotic.19921566153
pseudallescheria boydii genitourinary infection during bladder catheterization in a leukaemic patient. 19921573524
pseudallescheria boydii infection in the acquired immunodeficiency syndrome.pulmonary and renal infection developed in a 44-year-old hispanic man due to the fungus pseudallescheria boydii. pseudallescheria boydii has been associated with cutaneous infection known as mycetoma but occurs very infrequently in extracutaneous sites. to our knowledge, this is the second reported case of p boydii in a patient with the acquired immunodeficiency syndrome and the first case with pulmonary and/or renal involvement.19921580760
lung abscess due to pseudallescheria boydii in the course of acute leukaemia. report of a case and review of the literature.we report a case of lung infection by pseudallescheria boydii, which appeared during therapeutic aplasia in a patient with acute leukaemia. the association of sudden chest pain and fever with negative blood cultures and haemoptysic expectoration first suggested a diagnosis of pulmonary aspergillosis, in particular because evidence of lung abscesses appeared very rapidly and large mycelial filaments were found on direct examination of the expectoration. pseudallescheria boydii was identified by c ...19921585776
fungi associated with bovine abortion in the northern plains states (usa).mycotic infection was diagnosed in 6.8% of 6,858 cases of bovine abortion and stillbirth examined during a 9-year period. aspergilli were associated with approximately 5% of all abortion cases and 71% of 446 cases that were cultured for fungi and diagnosed as mycotic abortion. aspergillus fumigatus was the most frequent isolate (62%), followed by a. terreus (6.7%), emericella (aspergillus) nidulans (3.0%), a. flavus (2.9%), and e. rugulosus (less than 1.0%). zygomycetes (absidia, mortierella, rh ...19921616983
[therapy of systemic mycoses in neutropenic patients using itraconazole. a comparative, randomized study with amphotericin b].systemic mycosis constitute a serious threat for the patient with granulocytopenia. the most important causative agents are candida spp., aspergillus spp. and, to a lesser extent, cryptococcus neoformans, mucoraceae and pseudoallescheria boydii. treatment of such infections with amphotericin b is difficult, because of the many side-effects of this medicine, such as hypotension, fever, shivering, thrombophlebitis, nephrotoxicity, renal tubular acidosis, hypokalaemia, anaemia and thrombocytopenia. ...19911663200
disseminated nocardia transvalensis infection: an unusual opportunistic pathogen in severely immunocompromised patients.nocardia infections are infrequently recognized in humans. nocardia species may cause severe life-threatening infections among immunocompromised patients and have been reported to cause actinomycotic mycetomas, primarily in tropical areas. two severely immunocompromised patients had disseminated n. transvalensis infections. one had underlying x-linked variant chronic granulomatous disease and died of disseminated n. transvalensis infection, which was diagnosed only at postmortem examination. the ...19921727888
[fungus-induced arthritis caused by scedosporium apiospermum (pseudallescheria boydii)].scedosporium (monosporium) apiospermum is the most common causative agent of maduro mycosis. recent research reports claim that this fungus can also induce arthritis. we report on the disease in a woman from a rural area who was admitted to our clinic because of arthritis symptoms. we were able to detect scedosporium apiospermum, i.e., it was probably a fungus-induced arthritis which had developed after an intraarticular steroid injection.19911746172
pseudallescheria boydii keratitis.pseudallescheria boydii is one of the rarer organisms known to cause mycotic keratitis, only 13 previous cases having been reported in the literature. what is believed to be the first case of pseudallescheria boydii keratitis successfully treated with topical miconazole is reported here.19911776428
endogenous pseudallescheria boydii endophthalmitis. clinicopathologic findings in two cases.two cases of endogenous pseudallescheria boydii endophthalmitis are presented. one patient had severe pulmonary fibrosis but no history of ocular trauma and no clinical or laboratory evidence of immunocompromise. despite therapy with repeated intravitreal miconazole nitrate injections and systemic fluconazole, enucleation of the globe was required, and the patient eventually died with disseminated pseudallescheriasis. the other patient was an immunosuppressed cardiac transplant recipient who als ...19911841583
disseminated infection with pseudallescheria boydii in a patient with chronic granulomatous disease: response to gamma-interferon plus antifungal chemotherapy. 19911908570
the antigenic composition and protein profiles of eumycetoma agents.the protein profiles of different eumycetoma agents were compared by sds gel electrophoresis. dendrograms confirmed the homogeneity of isolates of pseudallescheria boydii but amongst madurella species, particularly isolates identified as m. grisea, there were substantial differences in protein composition. however using western blotting reference isolates of the different species showed distinct antigen patterns in response to immune rabbit sera. in particular there was little evidence of cross ...19911922185
fungal endophthalmitis. an experimental study with a review of 17 human ocular cases.pseudallescheria boydii is an opportunistic fungus that is histologically indistinguishable from aspergillus fumigatus. pseudallescheria boydii has been reported to cause endophthalmitis, orbital cellulitis, and corneal ulceration and is, thus, important to the ophthalmologist. a clinical review of 17 patients with p boydii ophthalmic infections is presented. in addition, animal models of endophthalmitides caused by a fumigatus and p boydii were created and compared. dutch-belted rabbits used fo ...19911929959
spectrophotometric method of inoculum preparation for the in vitro susceptibility testing of filamentous fungi.homogeneous inoculum suspensions of 29 isolates of clinically important filamentous fungi were adjusted with a spectrophotometer (530 nm) to obtain standardized preparations containing 1 x 10(6) to 5 x 10(6) cfu/ml. colony counts (cfu per milliliter) of 1 x 10(6) to 5 x 10(6) were achieved on three different days for isolates of aspergillus spp., pseudallescheria boydii, and sporothrix schenckii (80% +/- 2% transmission), and colony counts of 7 x 10(5) to 2.9 x 10(6) (70% +/- 2% transmission) we ...19912007647
surgical treatment for a case of postoperative pseudallescheria boydii endophthalmitis.pseudallescheria boydii (p. boydii) is an uncommon ocular pathogen which previously has been identified in only 10 of 905 fungal isolates identified by the sid richardson microbiology laboratory at the cullen eye institute of baylor college of medicine. furthermore, only one case of postoperative p. boydii endophthalmitis and four cases of endogenous p. boydii endophthalmitis have been reported. three of the four patients with endogenous endophthalmitis died within 4 weeks of diagnosis. we descr ...19912038484
the first case of pseudallescheria boydii meningitis in china--electron microscopic study and antigenicity analysis of the agent.reported in this paper is the first case of isolation of pseudallescheria boydii from cerebral spinal fluid of a boy with meningitis in china. morphology and culture were observed by light microscopy, electron scanning microscopy and transmission electron microscopy. in addition, mycelium antigen prepared by sds-page was compared with that of the other strain of scedosporium apiospermum. both of the strains showed more than 40 peptide lines. their molecular weight was very similar. on the cs-930 ...19902098578
pseudallescheria boydii infection of the central nervous system.pseudallescheria boydii is a rare cause of central nervous system infection characteristically presenting as a neutrophilic meningitis or multiple brain abscesses. factors predisposing to central nervous system infection with this fungus include immunosuppression and near drowning. the organism is infrequently cultured from fluid obtained by lumbar puncture, delaying clinical recognition and appropriate antifungal therapy. all untreated patients with p boydii infection of the central nervous sys ...19902181980
in vitro activities of polyene and imidazole antifungal agents against unusual opportunistic fungal pathogens.guidelines for the treatment of infections caused by unusual opportunistic fungi are limited and available in vitro data are scanty. in vitro susceptibility tests, employing an agar dilution procedure, were performed with amphotericin b (amb), natamycin (ntc), itraconazole (icz), and ketoconazole (ktz). two media were used: kimmig's agar (ka) and yeast morphology agar (yma). fungi tested included isolates (n) of acremonium spp. (10), cunninghamella spp. (6), fusarium spp. (18), pseudallescheria ...19902233893
pseudallescheria boydii and brain abscesses. 19902235148
persistent neutrophilic meningitis due to pseudallescheria boydii. 19902237138
the epidemiology of pseudallescheriasis complicating transplantation: nosocomial and community-acquired infection.the epidemiology of two cases of pseudallescheriasis in organ transplant patients are described and the disease in that population is reviewed. disseminated hospital-acquired infection occurred in a liver transplant recipient and was fatal despite therapy with miconazole. a heart transplant recipient developed localized disease following soil contamination of soft tissue trauma which was cured with surgical resection and miconazole therapy. itraconazole showed in vitro activity against pseudalle ...19902259370
native valve endocarditis due to pseudallescheria boydii in a patient with aids: case report and review.a 53-year-old man with aids developed mitral valve endocarditis due to infection with the fungus pseudallescheria boydii. a limited number of cases of prosthetic valve endocarditis caused by this organism have been described. we report a unique case of pseudallescheria infection of a native valve and describe this disease in a patient with aids.19902267494
mixed allergic bronchopulmonary fungal disease due to pseudallescheria boydii and aspergillus.a 24 year old asthmatic woman with mixed allergic bronchopulmonary fungal disease due to pseudallescheria boydii and aspergillus is reported. no previous cases due to p boydii have been described. this patient provides evidence that fungi other than aspergillus species may cause the condition.19902392795
eumycotic mycetoma caused by pseudallescheria boydii in a dog.abdominal eumycotic mycetoma caused by pseudallescheria boydii was diagnosed in a 3-year-old male siberian husky. the dog was examined because of weight loss and signs of depression. initially, pyrexia was the only clinical finding. antibiotic and corticosteroid treatment was ineffective. two weeks later, the dog's appetite had decreased, it had vomited a few times, and the caudal portion of the abdomen was sensitive to palpation. hematologic and serum biochemical abnormalities consisted of anem ...19892466820
etiological agents of otomycosis in nigeria.a total of 159 suspected cases of otomycosis comprising 101 adults and 58 children, 61 males and 98 females were investigated. of these, 36 cases were confirmed specifically of mycotic etiology on the basis of microscopic demonstration of fungal structures in epithelial debris/plugs and positive culture. another 31 cases positive for fungi by culture but negative for direct microscopy were considered of doubtful fungal etiology. the predominant etiological agents in the confirmed cases were aspe ...19892503721
cerebral pseudallescheria boydii infection: unique occurrence of fungus ball formation in the brain.pseudallescheria (petriellidium) boydii is the most frequent etiologic agent of mycetoma in temperate regions of the world. in addition, it may also occur as a systemic infection in immunocompromised patients. infection of the central nervous system is rare, and only eleven cases of pseudallescheria brain abscess have been documented. we report a leukemic patient in whom disseminated pseudallescheriasis was diagnosed only after death. this case is unique in that a white matter cavitation was pre ...19892538287
organ-specific variation in the morphology of the gungomas (fungus balls) of pseudallescheria boydii. 19892589943
studies on mycotic hundred and fifty cases of corneal ulcers from the government ophthalmic hospital, madras, were investigated during 1980-1982 for the mycoflora. 68 cases (45%) were positive for fungi, comprising species of aspergillus (36 cases), penicillium, fusarium (8 cases each), curvularia (4 cases), candida albicans and mucor (3 cases each), drechslera (2 cases) and cladosporium, cephalosporium, pullularia, and allescheria boydii (1 case each). incidence of these fungi in mycotic keratitis is correlat ...19892615780
actinomycotic intracavitary lung colonization.we describe four cases of actinomycotic intracavitary lung colonization and review the literature on the subject. aspergillus fumigatus, a. niger, a. flavus, pseudallescheria boydii are responsible for the majority of fungi intracavitary lung colonization (fungus ball). the similarities in clinical symptom (haemoptysis) and radiologic feature (pulmonary air meniscus) of fungus ball and actinomycotic intracavitary colonization prompted the investigation into a range of microorganisms, including n ...19892615797
potted plants in hospitals as reservoirs of pathogenic fungi.the soils of five potted plants cultivated within a hospital were investigated for the presence of fungal opportunistic pathogens of humans. a total of 16 potentially pathogenic species were isolated, including aspergillus fumigatus at up to 53.5 colony-forming units (cfu) per gram dry soil and scedosporium apiospermum (pseudallescheria boydii) at up to 97.0 cfu/g. other common species included phialophora verrucosa and fusarium solani. scedosporium inflatum, a recently described emerging pathog ...19892671744
central nervous system infection caused by pseudallescheria boydii: case report and review.pseudallescheria boydii is an uncommon cause of central nervous system (cns) infections. of a total of 21 cases of cns infections caused by p. boydii (one described for the first time and 20 reported previously in the english-language literature), eight occurred in immunosuppressed patients and four in patients who nearly drowned; three were trauma related and two were iatrogenic (epidural anesthesia and ventriculoperitoneal shunt, respectively); one occurred in a patient with insulin-dependent ...19892690286
organ-specific variation in the morphology of the fungomas (fungus balls) of pseudallescheria boydii. development within necrotic host tissue.pseudallescheria boydii is an increasingly important cause of infection in debilitated and immunocompromised persons. it is frequently found within pulmonary cavities, where it forms matted collections of fungal hyphae, variously termed fungus balls, fungomas, or pseudallescheriomas. this report describes the unusual occurrence of pseudallescheriomas in the lungs, brain, and kidney. the morphological features of the fungomas varied between involved organs, with those in the lung showing well-def ...19892712671
pseudallescheria boydii brain abscess: association with near-drowning and efficacy of high-dose, prolonged miconazole therapy in patients with multiple abscesses.brain abscess caused by pseudallescheria boydii is a highly lethal infection, usually seen in immunosuppressed patients. five patients with p. boydii brain abscesses are described. four of these patients acquired their infection after near-drowning; 1 patient developed an abscess after penetrating head trauma. two patients survived their infections, which included involvement of other body sites (lung, eye, bone) as well as multiple undrained brain abscesses, after prolonged courses of high-dose ...19892739563
new spectrum of fungal infections in patients with cancer.we report on 44 cancer patients who had serious infections with unusual fungal pathogens and who were cared for at our cancer center between 1974 and 1986. twelve different fungal species accounted for these infections, including trichosporon beigelii, fusarium species, geotrichum candidum, curvularia species, drechslera species, penicillium species (but not penicillium marneffei), rhodotorula rubra, pseudallescheria boydii, pichia farinosa, torulopsis pintolopesii, saccharomyces cerevisiae, and ...19892749101
mycotic keratitis in madras.corneal scrapings from 698 clinically suspected cases of mycotic keratitis were investigated for evidence of fungal infection. of these, 322 were found to be positive by direct examination and/or culture. the infection was predominantly seen in the age group 21-50. men were more frequently affected than women. majority of the patients were either agricultural workers or out door manual labourers and 66.8% of them gave a definite history of antecedent corneal trauma due to vegetable or soil matte ...19892777350
pseudallescheria boydii keratomycosis in a horse.the fungal organism pseudallescheria boydii was isolated from the cornea of a quarter horse with ulcerative keratitis. despite aggressive hourly medication through a subpalpebral lavage system, with drugs including miconazole and natamycin, the cornea developed a stromal abscess. orbital exenteration was performed after 3 weeks. the fungal isolate was later determined to be resistant to all 8 antifungal drugs tested. microscopic examination of the cornea revealed fungal hyphae throughout the cor ...19892777709
in vitro interactions between blastomyces dermatitidis and other zoopathogenic fungi.the results of in vitro interactions between colonies of blastomyces dermatitidis and six other zoopathogenic fungi are reported. the interactions were found to range from neutral with histoplasma capsulatum and candida albicans to strongly antagonistic with microsporum gypseum, pseudallescheria boydii, and sporothrix schenckii, and including lysis by cryptococcus neoformans. these observations suggest that interactions between zoopathogenic fungi may be one of the biotic factors likely to influ ...19883058276
pseudallescheriasis in northern britain.five cases of pseudallescheria boydii infection are reported from the northern part of the united kingdom. none of the patients had travelled abroad. three cases of otitis in which p. boydii was associated with bacterial infections were diagnosed within a 6-month period. a lady who had diabetes mellitus presented with a pulmonary fungus ball in a pre-existent cavity caused by a previous bacterial infection. after minor trauma at the site of an old skin graft, a farmer's wife developed an ulcer o ...19863097296
pseudallescheria boydii mycetoma in northern new england.mycetoma is a chronic subcutaneous fungal infection characterized by tumefaction, draining sinuses, and grains. it is most common in the tropics but occasionally occurs in the united states. we report a case of a mycetoma affecting the foot of a 38-year-old mentally retarded man from northern new england. the causal organism was identified as pseudallescheria boydii, the most common cause of mycetoma in the united states. the patient showed a partial response to 8 months of ketoconazole therapy.19883229880
bilateral pseudallescheria boydii endophthalmitis in an immunocompromised patient. 19883282394
invasive aspergillosis diagnosed by immunohistochemistry with monoclonal and polyclonal reagents.therapies differ for invasive infection due to the various filamentous fungi. however, histopathologic identification of aspergillus, pseudallescheria, fusarium, trichosporon, dematiacious hyphomycetes, candida, and zygomycetes may be confused, and microbiologic isolation is often delayed. to improve diagnosis, we examined the utility of polyclonal and monoclonal antibodies to identify aspergillus organisms by peroxidase immunohistochemical techniques. tissues obtained from 68 infected patients ...19873308679
eumycotic mycetoma: review and report of a cutaneous lesion caused by pseudallescheria boydii in a horse.a cutaneous mass (1.5 cm in diameter) was removed from the head of a horse and was diagnosed histologically as eumycotic mycetoma. immunofluorescence, performed on formalin-fixed, paraffin-embedded tissue, identified pseudallescheria boydii as the etiologic agent. findings from earlier reports of eumycotic mycetoma were compared with those of this horse.19873319985
eumycotic mycetoma caused by pseudallescheria boydii in the abdominal cavity of a abdominal eumycotic mycetoma with multiorgan dissemination was diagnosed in a 2-year-old dog. clinical signs included fever, vomiting, diarrhea, weight loss, and a palpable abdominal mass. the dog developed disseminated intravascular coagulation and died. pseudallescheria boydii was isolated from the abdominal mass, liver, and peritoneal fluid. relevant history included an ovariohysterectomy when the dog was 6 months old, which was complicated by dehiscence of the incision site and eviscerati ...19883343183
pseudallescheria boydii brain abscess. complication of an intravenous adult patient survived a brain abscess with pseudallescheria boydii. she received intraventricular miconazole, 20 mg every 72 hours (minimal inhibitory concentration = 0.4 microgram/ml), and surgery. the abscess resulted from an infected central venous catheter (port-a-cath) and steroid therapy. miconazole caused a ventriculitis. there are 12 reported cases of p. boydii brain abscesses from 1965 to 1985 with only two survivors.19883407662
treatment of pseudallescheria boydii infection with oral ketoconazole and topical miconazole. 19873426479
endogenous pseudoallescheria boydii endophthalmitis. a clinicopathologic report. 19863488853
pseudallescheria boydii infection of the central nervous system in a cardiac transplant recipient.we have described a cardiac transplant recipient with fatal pseudallescheria boydii infection of the central nervous system. unusual features included meningitis without brain abscess and noncommunicating hydrocephalus due to exuberant growth of the organism in the ventricular fluid. long-term amphotericin b administration may have played a role in the development of this infection.19863513333
multiple mycetomas due to pseudallescheria boydii.a patient with pulmonary sarcoidosis had evaluation of hemoptysis. a ct scan of the chest showed bilateral upper lobe cavities and five separate mycetomas with air-crescent signs. bronchial washings were positive on stains for fungal elements, and all cultures grew pseudallescheria boydii. we have not seen a previous report of multiple fungus balls due to p boydii demonstrated by chest ct.19873576275
leucocyte chemotaxis to mycetoma agents--the effect of the antifungal drugs griseofulvin and ketoconazole.polymorphonuclear leucocytes are the predominant cell type in the inflammatory infiltrate around mycetoma grains. human leucocyte chemotaxis using cells from healthy subjects has been demonstrated using cytoplasmic antigens from 3 mycetoma agents: madurella mycetomatis and pseudallescheria boydii, both fungi, and streptomyces somaliensis, an actinomycete. there was a statistically insignificant increase in chemotaxis in the presence of ketoconazole, but griseofulvin was a potent inhibitor of leu ...19873617197
[epidemiologic study of mycetomas in mexico. apropos of 502 cases].the epidemiological data of 502 mycetomas studied in the department of mycology, "centro dermatológico pascua", mexico city, were analysed. mycetomas prevail in males (79.7%), they are more frequent between 16 and 45 years of age (75%) and among rural workers (62.5%); they preferentially affect lower limbs (62.5%); these data are generally similar to the known publications on the matter. actinomycetomas are the most frequent with 97.2% of the cases, distributed as follows: nocardia: 85.6% among ...19873621395
biotyping of micelial fungus cultures by the killer system.based on the occurrence of the yeast killer phenomenon in hyphomycetes, the toxic effect of 37 selected killer yeasts was studied on eleven strains of pseudallescheria boydii, six strains of aspergillus niger, 18 strains of penicillium camemberti and nine strains of sporothrix schenckii. the demonstration of different biotypes within the species of p. boydii and p. camemberti proves that the killer system also is a practical and effective method for epidemiological studies among hyphomycetes. ba ...19873653352
postcraniotomy mycetoma of the scalp and osteomyelitis due to pseudallescheria boydii. 19873655408
nasal granuloma caused by pseudallescheria boydii. 19863698957
pseudallescheria boydii arthritis and osteomyelitis in a patient with cushing's disease.pseudallescheria boydii infection involving the left distal femur and knee joint developed in a patient with cushing's disease, and recurred after treatment with both intravenous miconazole and intravenous amphotericin b. the patient subsequently had synovectomy and arthrodesis, and received ketoconazole, 600 mg per day orally for one year. concurrent with the start of ketoconazole, a bilateral adrenalectomy was done to control endogenous hypercortisolism. the patient's infection then resolved, ...19873798191
pseudoallescheria boydii soft tissue abscess.pseudoallescheria boydii, a fungus often isolated from soil, commonly causes a mycetoma. successful treatment involves resection of the infected area and appropriate antifungal chemotherapy. in vitro sensitivity of p. boydii to miconazole is usually demonstrated, but resistance to amphotericin b and 5-fluorocytosine is often observed. limited data are available on the treatment of this infection with ketoconazole. an usual case of nontraumatic p. boydii soft tissue infection without draining sin ...19873802640
miconazole therapy in pseudallescheria boydii infection. 19853835956
systemic pseudallescheriasis in a patient with acute myelocytic leukemia.presented is a case of widely disseminated systemic pseudallescheriasis in a 41 year old male with acute myelocytic leukemia. the immediate cause of death appeared to be due to an extensive invasion of the lungs which showed massive intra-alveolar hemorrhages, congestion, mycotic thrombi, and multiple fungal lesions in all lobes. pseudallescheria boydii was diagnosed histopathologically by virtue of its characteristic conidia present in miliary lesions throughout a wide range of host's tissues, ...19853859751
clinical significance of pseudallescheria boydii: a review of 10 years' experience.pseudallescheria boydii is a recognized cause of mycetoma, a chronic fungal disease that usually affects the extremities. isolated case reports have also implicated p. boydii in infections of other sites. we report the first large series (83 isolates) of p. boydii in 46 patients, including the second report of p. boydii brain abscess and disseminated infection in a noncompromised host. between 1974 and 1984 at our institution, p. boydii was cultured from a variety of sites: respiratory tract, 36 ...19853894816
post-craniotomy wound infection caused by pseudallescheria boydii. case report.the authors describe the first reported case of post-craniotomy wound infection due to pseudallescheria boydii. the patient was a 24-year-old man who sustained a direct blunt injury to the calvaria, resulting in a large subdural hematoma that was surgically evacuated. subsequently, the surgical wound became infected with a fungus, p. boydii, and was successfully treated with intravenous miconazole.19863941340
case report: prosthetic valve endocarditis caused by pseudallescheria boydii and clostridium limosum.this report describes a patient with a combined infection due to pseudallescheria boydii and clostridium limosum on a prosthetic dura mater aortic valve homograft. while this patient had c. limosum only growing in blood cultures, both organisms were isolated from the surgically resected aortic valve. because p. boydii is generally resistant to amphotericin b but susceptible to miconazole, accurate differentiation of p. boydii from other fungi which may appear similarly in tissue sections (e.g., ...19853990765
an additional case of pulmonary pseudallescheria boydii improved with ketoconazole therapy. 19853996080
brain abscesses due to pseudallescheria boydii associated with primary non-hodgkin's lymphoma of the central nervous system: a case report and literature review.a 54-year-old man with primary non-hodgkin's lymphoma of the thoracic spinal cord developed multiple brain abscesses caused by pseudallescheria boydii. the patient had received radiotherapy and corticosteroid treatment before developing the brain abscesses. antemortem diagnostic evaluations were inconclusive, and diagnosis was finally made from postmortem brain specimens by the use of histologic examination and isolation of the fungus in culture. the portal of entry for the organism was unknown, ...19854001716
pseudallescheria boydii (petriellidium boydii) infection of the orbit.a 10-year-old male developed a chronic orbital infection following penetrating trauma and retention of an orbital foreign body. diagnosis of infection with pseudallescheria boydii (petriellidium boydii) was made by fungal smear and culture. sensitivity tests indicated the organism was resistant to amphotericin b. surgical debridement of the inferior orbit and removal of the foreign body was followed by a six-week course of intravenous miconazole. the patient has shown no signs of recurrence in a ...19854011116
mycologic, serologic and histologic findings in bovine abortion associated with allescheria boydii. 19744210101
allescheria boydii: wild type and a variant from human pulmonary allescheriasis. 19744850480
eumycotic mycetoma in a dog caused by allescheria boydii. 19704920066
in vitro antifungal activity of clotrimazole (bay b 5097).the in vitro antifungal activity of clotrimazole (bay b 5097) was compared with those of amphotericin b, griseofulvin, nystatin, and pyrrolnitrin. the inhibitory activity of clotrimazole against most systemic pathogens was comparable to that of amphotericin b; minimal inhibitory concentrations of the two drugs for blastomyces dermatitidis, histoplasma capsulatum, sporothrix schenckii, cryptococcus neoformans, and coccidioides immitis were in the range of 0.20 to 3.13 and 0.10 to 6.25 mug/ml, res ...19714949484
pulmonary mycetoma due to allescheria boydii. 19694979745
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