| fungicidal properties of a chymotrypsin-like cationic protein from human neutrophils: adsorption to candida parapsilosis. | human neutrophils contain a chymotrypsin-like cationic protein (clcp) that binds to the surface of candida parapsilosis and is preferentially adsorbed by yeasts mixed with unfractionated extracts of neutrophil granules. adsorption of clcp to opsonized or nonopsonized yeasts was rapid at ph 4 through 8. irreversible inhibition of the enzymatic site of clcp by phenylmethylsulfonylfluoride or n-acetyl-ala-ala-phe-chloromethyl ketone did not affect its adsorption by yeast. adsorption, highly sensiti ... | 1977 | 19359 |
| transport kinetics of 6-deoxy-d-glucose in candida parapsilosis. | the strictly aerobic yeast candida parapsilosis transports the nonmetabolizable monosaccharide 6-deoxy-d-glucose by an active process (inhibition by 2.4-dinitrophenol and other uncouplers but not by iodoacetamide), the accumulation ratio decreasing with increasing substrate concentration. measured accumulation ratios are in agreement with those predicted from kinetic constants for influx and efflux. energy for transport is probably required in the translocation step. the maximum rate is temperat ... | 1978 | 23984 |
| mycological profile of crew during 56-day simulated orbital flight. | mycological analyses were made on specimens obtained from the skin, oral rinse, urine, and feces of three subjects participating in a 56 day skylab simulation test. samples were taken over a 175 day period divided into three phases consisting of a prechamber, intrachamber, and postchamber period. a total of 69 species of filamentous fungi and 22 species of yeast and yeast-like fungi were recovered and identified. there was a marked decrease in the isolation incidence of both the filamentous and ... | 1978 | 29227 |
| autoregulation of germ tube formation by candida albicans. | germ tube formation by candida albicans is at least partially controlled by a product(s) of the yeast phase of the organism which is released from cells upon incubation at 37 degrees c in tissue culture medium or fetal calf serum. this germination regulatory substance is stable under conditions of lyophilization and heating of 70 degrees c, but becomes inactivated at ph values of 4.0 and 9.5. a germination regulatory substance was produced by both strains of c. albicans tested and by a strain of ... | 1979 | 89087 |
| the fungicidal mechanisms of human monocytes. i. evidence for myeloperoxidase-linked and myeloperoxidase-independent candidacidal mechanisms. | we tested the ability of human peripheral blood monocytes to kill candida albicans and candida parapsilosis. evidence that multiple fungicidal mechanisms operate in normla monocytes was found. normal monocytes ingested and killed viable c. albicans, and could iodinate heat-killed c. albicans. both functions were defective in monocytes from subjects with myeloperoxidase deficiency or chronic granulomatous disease. methimazole, isoniazid, and aminotriazole inhibited iodination by normal monocytes ... | 1975 | 123929 |
| experimental hematogenous endophthalmitis due to candida: species variation in ocular pathogenicity. | the ocular pathogenicity of species of candida other than albicans was studied in the rabbit model of hematogenous candida endophthalmitis by injection of 10(5)-10(8) colony-forming units of candida krusei, candida parapsilosis, candida guilliermondii, candida tropicalis, candida stellateoidea, and candida albicans (control). at one and three weeks after infection, rabbits were examined by indirect ophthalmoscopy and were sacrificed for culture of eyes and kidneys. with an inoculum of 10(8) orga ... | 1977 | 320277 |
| occurrence of human-associated yeasts in bivalve shellfish from long island sound. | candida parapsilosis, c. tropicalis, and torulopsis glabrata were the human-associated yeasts most frequently isolated from quahogs, oysters, and mussels collected from four estuarine areas along the northern shore of long island sound. some inconsistency and seasonal variation in the occurrence of these and other yeast species were noted. in particular, c. albicans densities were greatest during colder months in the more heavily polluted waters. a total of 347 yeasts were isolated and cultured ... | 1977 | 322610 |
| fungicidal components of mammalian granulocytes active against cryptococcus neoformans. | citric acid extracts of granule-rich fractions, prepared from rabbit and guinea pig heterophils or human neutrophis, killed cryptococcus neoformans in vitro. these extracts sere fractionated by micropreparative electrophoresis on polyacrylamide gels. in preparation of rabbit and guinea pig heterophils, cryptococcidal activity was associated predominantely with lysosomal cationic protein complex. human neutrophils lacked strictly comparable cationic proteins but contained other components that ki ... | 1977 | 328789 |
| results of combined amphotericin b-5-fluorcytosine therapy for prosthetic knee joint infected with candida parapsilosis. | a prosthetic knee joint became infected with candida parapsilosis, apparently introduced by arthrocentesis. the infection was quite indolent, present for several months before treatment. although the joint fluid contained antibiotic concentrations in excess of the organism's minimum inhibitory concentration, medical therapy failed, and cure required removing the prosthesis and fusion of the knee. | 1979 | 392095 |
| nosocomial outbreak of candida parapsilosis fungemia related to intravenous infusions. | candida parapsilosis is rarely isolated from blood cultures. our hospital surveillance detected an increased rate of isolation of c parapsilosis during a four month period. fourteen postoperative patients receiving intravenous (iv) hyperalimentation and eight burn patients receiving iv albumin were involved. hectic fever, the major clinical manifestation, was seen in 61% of cases. therapy in the postoperative patients consisted merely of discontinuing iv catheters and hyperalimentation, while am ... | 1977 | 412474 |
| assimilation of protocatechuic acid and p-hydroxybenzoic acid as an aid to laboratory identification of candida parapsilosis and other medically important yeasts. | test for the ability of yeasts isolated from clinical specimens to utilize protocatechuic acid and p-hydroxybenzoic acid were carried out by using techniques that are commonly employed to test assimilation of carbon sources. a total of 60 isolates of candida parapsilosis and 5 isolates of candida humicola readily assimilated these two phenolic acids, whereas other candida species gave uniformly negative results. cryptococcus albidus, cryptococcus terreus, and some isolates of cryptococcus lauren ... | 1979 | 489723 |
| candida parapsilosis endocarditis: medical and surgical cure. | | 1979 | 517889 |
| [folliculitis barbae candidomycetica from candida parapsilosis]. | in this case report the rarity of the causing agent, candida parapsilosis, and its endothrix growth is accentuated. the unsuccessful application of local and systemic antimycotics required the surgical abrasion of the infected tissue. | 1979 | 521288 |
| isolated candida parapsilosis arthritis in a heroin addict. | a case of isolated candida parapsilosis arthritis involving the shoulder of a heroin addict is described. amphotericin b successfully eradicated the infection after failure of flucytosine. optimal therapy for this condition has not been determined. | 1979 | 522093 |
| successful medical therapy for endocarditis due to candida parapsilosis. a clinical and epidemiologic study. | a heroin addict with asymmetric septal hypertrophy and persistent fungemia with candida parapsilosis was treated with amphotericin b and flucytosine (5-fluorocytosine). the diagnosis of endocarditis was based on the subsequent development of a murmur of mitral regurgitation and echocardiographic evidence of prolapse of the posterior leaflet of the mitral valve. cure was effected with antifungal therapy alone. thus, when the diagnosis of fungal endocarditis is made early in its course, open-heart ... | 1978 | 630978 |
| comparison of the in vitro antifungal activities of miconazole and a new imidazole, r41,400. | r41,400 is a recently synthesized, water-soluble imidazole. its antifungal properties were compared in vitro with those of miconazole using an agar dilution procedure and 175 isolates of human fungal pathogens. the filamentous forms of histoplasma capsulatum and blastomyces dermatitidis were inhibited by less than or equal to 2 microgram of either drug/ml; coccidioides immitis was inhibited by less than or equal to 0.5 microgram of r41,400/ml. among the yeasts tested, cryptococcus neoformans and ... | 1978 | 681800 |
| rubidium release: a rapid and sensitive assay for amphotericin b. | a new assay for amphotericin b has been devised with use of the release of a radioactive potassium analogue (86rubidium; 86rb) from candida parapsilosis. the 86rb-release assay is rapid, highly sensitive, and reproducible. amphotericin b levels of 0.06-2.0 mug/ml can be measured in serum, whereas as little as 0.015 mug of amphotericin b/ml can be detected in spinal fluid. the greater sensitivity of the assay in spinal fluid as compared with that in serum may be the result of binding of the ampho ... | 1976 | 789783 |
| effect of culture media on the antifungal activity of miconazole and amphotericin b methyl ester. | the capacity of four culture media to obfuscate the antifungal activity of miconazole and amphotericin b methyl ester was evaluated qualitatively by examination of five isolates each of candida albicans, candida tropicalis, candida parapsilosis, torulopsis glabrata, and cryptococcus neoformans, and quantitatively by determination of the absolute minimal inhibitory concentrations for a strain of c. albicans. miconazole, like the predecessor imidazole (clotrimazole), was antagonized by two complex ... | 1976 | 789787 |
| occurrence of histoplasma capsulatum darling, 1906 in israel, with a review of the current status of histoplasmosis in the middle east. | the isolation of histoplasma capsulatum from a bat cave in the galilee region of israel is reported along with the discovery of a bat (myotis myotis) infected by h. capsulatum. soils collected in avian and chiropteran habitats throughout israel also yielded the following fungi of medical interest: arthroderma quadrifidum, a. tuberculatum, candida parapsilosis, chrysosporium indicum, c. keratinophilum, c. tropicum, cryptococcus neoformans, ctenomyces serratus, microsporum gypseum, and petriellidi ... | 1977 | 842775 |
| efficiency of oxidative phosphorylation in continous cultures of candida parapsilosis. | by using a gas balance technique, the effective oxidative phosphorylation ratio in glucose-limited continuous cultures of candida parapsilosis was calculated to be 2.4 +/- 0.2. when this value was used, the molar growth yield with respect to adenosine 5'-triphosphate was found to be 10 g of cells produced per mol of atp. | 1977 | 853034 |
| yeasts in bovine semen. | a total of 129 semen samples from 62 bulls were examined for the presence of mycelial yeasts. nine species of mycelial yeasts were obtained from the semen; candida parapsilosis and c. tropicalis were the most frequently isolated organisms. semen samples from 30 of the bulls had mycelial yeasts present. | 1976 | 954443 |
| thermal adaptation in yeast: growth temperatures, membrane lipid, and cytochrome composition of psychrophilic, mesophilic, and thermophilic yeasts. | the temperature limits of growth of a number of yeast species were examined, and on this basis the organisms were classified into different thermal categories. the following species were examined: leucosporidium frigidum and leucosporidium nivalis, psychrophilic, temperature limits of growth, -2 to 20 degrees c; canadian lipolytica mesophilic, temperature limits of growth, 5 to 35 degrees candida parapsilosis and saccharomyces telluris, thermotolerant, temperature limits of growth, 8 to 42 degre ... | 1976 | 988016 |
| isolation of dermatophytes, candida species and systemic fungi from dermatologic specimens in montréal, 1963 to 1973. | of 10 057 specimens of scrapings from skin, nails and scalp examined for dermatophytes, yeasts, pityriasis versicolor and systemic mycoses between 1963 and 1973, 30.4 percent were positive for fungi. skin produced the highest proportion (68.6 percent) of positive scrapings, scalp the lowest (4.2 percent). trichophyton rubrum was the predominant species (23.6 percent); of lesser prevalence were microsporum canis (9.3 percent), t. mentagrophytes (8.4 percent) and epidermophyton floccosum (4.8 perc ... | 1975 | 1091342 |
| [a case of unilateral endogenous intraocular mycosis through candida parapsilosis (author's transl)]. | the clinical course of a unilateral intraocular mycosis through candida parapsilosis is described. the fungus could be histologically verified from a whitish yellow thick deposits on the lens in the anterior chamber after enucleation of the eye. the ocular infection was endogenic probably through an infested cava-catheter. | 1975 | 1117648 |
| fungal endocarditis: analysis of 24 cases and review of the literature. | fungal endocarditis occurs in heroin addicts, patients who have undergone cardiovascular surgery, and patients who are treated for prolonged periods with intravenous fluids and broad spectrum antibiotics. the organisms associated with endocardial infection differ in each of these groups. candida parapsilosis is the fungal species most commonly isolated from narcotics addicts, aspergillus species are most frequently found in patients after cardiovascular surgery, and candida albicans occurs most ... | 1975 | 1171349 |
| synergistic action of amphotericin b and rifampin against candida species. | amphotericin b and rifampin act synergistically against certain yeasts in vitro. whether this synergism is a general phenomenon or whether the effect has strict species and strain requirements was studied. included in a survey of the genus candida were eight human isolates of candida albicans and one strain each of candida krusei, candida tropicalis, candida pseudotropicalis, candida parapsilosis, candida guilliermodnii, and candida stellatoidea. cultures in both control and drug-containing liqu ... | 1976 | 1245767 |
| interaction of terbinafine with human serum and serum proteins. | the allylamine antimycotic terbinafine acts by inhibition of ergosterol biosynthesis at the level of squalene epoxidase. using this mechanism in candida parapsilosis cells, a functional assay was developed to investigate the effects of serum and serum proteins on the antifungal action of terbinafine and related drugs in vitro. inhibition of ergosterol biosynthesis by terbinafine was antagonized by human serum in a dose-dependent non-saturable manner. the results were not affected by varying the ... | 1992 | 1287164 |
| hepatosplenic infection caused by candida parapsilosis in patients with acute leukemia. | candida parapsilosis is an exceptional agent in hepatosplenic candidosis. here we report two cases of hepatosplenic infection caused by candida parapsilosis in two patients with acute leukaemia. open liver-spleen biopsy and previously minimal exposure to systemic antifungal drugs led to a cultural diagnosis in both patients. this report confirms the importance of an early diagnosis of these diseases in order to undertake appropriate therapeutic regimens. | 1992 | 1302805 |
| endocarditis caused by candida parapsilosis. | the authors report a case of endocarditis caused by candida parapsilosis. to the best of our knowledge, a case has not been described previously in japan in the english literature. a battery of 8 peroxidase-labeled lectins was tested on sections of paraffin-embedded tissue to determine which lectin could be used in the microscopic diagnosis of c. parapsilosis. one lectin, from archis hypoaea (pna) was found to react with c. parapsilosis. on the other hand, c. albicans, aspergillus, mucor, and cr ... | 1992 | 1326123 |
| pigeons and peritonitis? | we report an outbreak of fungal peritonitis due to candida parapsilosis in 12 patients undergoing chronic ambulatory peritoneal dialysis (capd). all 12 patients were treated by removal of the capd catheter together with systemic antifungal therapy. there were no peritonitis-related deaths. four patients were successfully returned to capd at a later date. microbiological investigation during the outbreak demonstrated colonization of various areas of the capd unit and medical ward with the organis ... | 1992 | 1328948 |
| in vitro susceptibility of 245 yeast isolates to amphotericin b, 5-fluorocytosine, ketoconazole, fluconazole and itraconazole. | the in vitro activity of amphotericin b, 5-fluorocytosine, ketoconazole, fluconazole and itraconazole was tested against 245 yeast strains isolated from clinical specimens (68 candida albicans, 74 candida tropicalis, 43 candida krusei, 28 candida glabrata, 19 candida parapsilosis, 8 candida lusitaniae and 5 candida guilliermondii). an agar dilution method was employed to carry out testing. minimal inhibitory concentrations to restrain 90% of isolate growth (mic90) ranged from 0.12 to 2 mg/l for ... | 1992 | 1337508 |
| candida parapsilosis: epidemiology, pathogenicity, clinical manifestations, and antimicrobial susceptibility. | early reports associated candida parapsilosis with endocarditis in intravenous narcotic addicts. more recently, this species has emerged as an important nosocomial pathogen, with clinical manifestations including fungemia, endocarditis, endophthalmitis, septic arthritis, and peritonitis, all of which usually occur in association with invasive procedures or prosthetic devices. outbreaks of c. parapsilosis infections have been caused by contamination of hyperalimentation solutions, intravascular p ... | 1992 | 1345554 |
| microbial contamination of brushes used for preoperative shaving. | microbial contamination of brushes used for preoperative shaving was investigated. of the 24 brushed examined, 18 were contaminated with 10(6)-10(9) colony forming units (cfu) per brush. non-fermentative gram-negative bacilli such as pseudomonas aeruginosa and xanthomonas maltophilia, and yeast-like fungi such as candida parapsilosis were the primary contaminants. the mean bacterial count on the skin after the use of contaminated brushes (having a mean bacterial count 2.2 x 10(8) cfu) in 14 subj ... | 1992 | 1353085 |
| solubilization of limulus test reactive material(s) from candida cells by murine phagocytes. | solubilization of limulus test reactive materials from candida was examined in the presence or absence of phagocytic cells. solubilized limulus test reactive materials (ltrm) were detected in culture supernatant, and hot water and sodium hydroxide extracts of the acetone dried cells of candida parapsilosis. suspensions of candida cells also reacted with limulus test, and ltrm were released from the acetone dried cells by serum treatment. after treatment of the acetone dried cells with polymorpho ... | 1992 | 1394673 |
| effects of fluconazole on the sterol and carbohydrate composition of four species of candida. | the effects of fluconazole, a bis-triazole antifungal agent, on the sterol and carbohydrate composition of candida albicans, candida tropicalis, candida krusei and candida parapsilosis were investigated. exposure of candida species to fluconazole resulted in a profound depletion of ergosterol with a corresponding increase in lanosterol content versus control cells. carbohydrate analysis revealed a significant increase in chitin and either a decrease (candida albicans, candida tropicalis and cand ... | 1992 | 1396728 |
| colony morphotype on sabouraud-triphenyltetrazolium agar: a simple and inexpensive method for candida subspecies discrimination. | a new method of candida subspecies discrimination on sabouraud-triphenyltetrazolium agar is reported. five hundred sixty-two strains of candida and torulopsis glabrata, previously identified by conventional mycological methods, were studied. each strain received a three-letter code and a number based on its colonial morphology. sixteen morphotypes were found for candida albicans, 6 were found for candida parapsilosis, 4 were found for both candida guilliermondii and candida krusei, and 12 were f ... | 1992 | 1400981 |
| [analysis of 84 cases with fungemia]. | eighty-four patients with fungemia were analyzed. fungi had been isolated by culture of blood samples, including blood from the catheter for intravenous hyperalimentation, between 1986-1990. candida albicans (39.3%), candida parapsilosis (20.2%), candida tropicalis (11.9%), candida glabrata (10.7%), candida guilliermondii (4.8%) and trichosporon beigelii (4.8%) were the most frequently isolated fungal pathogens. four patients' blood yielded two different fungal species. fifty-nine cases were mal ... | 1992 | 1402094 |
| [limulus test (factor g) and polysaccharides from fungus]. | picogram quantifies per ml of endotoxin showed a positive limulus test. the concentration more than ten pg/ml of curdlan ((1-3)-beta-d-glucan) was also positive to a conventional limulus test, which contains a factor g. one nanogram per ml of cm-curdlan was positive, but higher concentration of 10 pg/ml of cm-curdlan decreased its optical density of the conventional limulus test. more than one hundred ng/ml of mannan from saccharomyces cerevisiae did not react with factor g. however, a culture s ... | 1992 | 1402105 |
| [the intestinal microflora of persons subjected to a radiation lesion]. | the content of large intestine has been studied in persons exposed to radiation injury in consequence of the accident at the chernobyl atomic power plant. it is stated that bifidobacteria (10(7)-10(10) cells in 1 g of feces) prevailed (as in healthy people), bifidobacterium indicum being a dominating species. amount of lactic-acid bacteria in 1 g of defecations of examined patients was within the range of 10(6)-10(9) cells and in certain persons it reached 10(10) cells (primarily fecal enterococ ... | 1992 | 1406381 |
| degradation of some phenols and hydroxybenzoates by the imperfect ascomycetous yeasts candida parapsilosis and arxula adeninivorans: evidence for an operative gentisate pathway. | the imperfect ascomycetous yeasts candida parapsilosis and arxula adeninivorans degraded 3-hydroxybenzoic acid via gentisate which was the cleavage substrate. 4-hydroxybenzoic acid was metabolized via protocatechuate. no cleavage enzyme for the latter was detected. in stead of this nadh- and nadph-dependent monooxygenases were present. in cells grown at the expense of hydroquinone and 4-hydroxybenzoic acid, enzymes of the hydroxyhydroquinone variant of the 3-oxoadipate pathway were demonstrated, ... | 1992 | 1416914 |
| biliary concentrations of fluconazole in a patient with candidal cholecystitis: case report. | a patient with acute cholecystitis due to candida albicans and candida parapsilosis was treated with a percutaneous cholecystostomy and daily intravenous fluconazole. fluconazole levels in serum and bile were measured by gas chromatography. fluconazole levels in the bile were equal to those in the blood for the first 8 hours after a dose and were slightly higher than serum levels after that. bile levels after an oral dose of fluconazole were 15% higher than levels achieved after intravenous admi ... | 1992 | 1420685 |
| efficacy of fluconazole in the treatment of systemic fungal infections. | the efficacy of fluconazole in the treatment of systemic fungal infections was evaluated in an open non-comparative trial. a total of 48 patients with proven or suspected fungal infections were enrolled in 40 of whom efficacy was evaluable. candida albicans accounted for 90% of the infections. candida parapsilosis, candida glabrata, histoplasma capsulatum and aspergillus fumigatus caused the infection in one case each. fluconazole was administered at a dosage of 200-400 mg daily for a mean durat ... | 1992 | 1425709 |
| prediction of transmembrane topology of f0 proteins from escherichia coli f1f0 atp synthase using variational and hydrophobic moment analyses. | the a subunit, a membrane protein from the e. coli f1f0 atp synthase has been examined by fourier analysis of hydrophobicity and of amino-acid residue variation. the amino-acid sequences of homologous subunits from vibrio alginolyticus, saccharomyces cerevisiae, neurospora crassa, aspergillus nidulans, schizosaccharomyces pombe and candida parapsilosis were used in the variability analysis. by fourier analysis of sequence variation, two transmembrane helices are predicted to have one face in con ... | 1992 | 1445940 |
| detection of serum candida antigens by enzyme-linked immunosorbent assay and a latex agglutination test with anti-candida albicans and anti-candida krusei antibodies. | serum samples from 197 patients with and without candidiasis were assayed for candida albicans mannan and candida krusei mannan by an enzyme-linked immunosorbent assay (elisa) and a latex agglutination test (la) and for d-arabinitol by the enzymatic fluorometric method. of the 43 patients positive for c. albicans mannan (> or = 0.2 ng/ml), 34 were infected with c. albicans and 9 were infected with candida tropicalis. c. krusei mannan (> or = 0.3 ng/ml) was detected in 10 patients infected with c ... | 1992 | 1452696 |
| prosthetic joint infection due to candida parapsilosis in the uk: case report and literature review. | candida infection of joint replacements is a rare but increasingly reported phenomenon. a case of candida parapsilosis prosthetic knee joint infection occurring in the uk is described. cure followed removal of the prosthesis and treatment, first with a combination of amphotericin and 5-fluorocytosine, then ketoconazole. | 1992 | 1468427 |
| [nosocomial fungemia caused by candida parapsilosis]. | we review 27 episodes of nosocomial fungemia due to candida parapsilosis over a 6 year period, compared to a control group of 27 episodes of nosocomial fungemia due to candida albicans. during the study period, c. parapsilosis accounts for 23% of all yeast isolated from blood-cultures. fungemia due to c. parapsilosis was more frequently seen in males (23/4). more than half of the cases (15/27) presented in the postoperative period. in 89% of cases the patients were under total parenteral nutriti ... | 1992 | 1489791 |
| candidemia in a tertiary care hospital: epidemiology, risk factors, and predictors of mortality. | demographic information, risk factors, therapy, and outcome for all patients who had candidemia at barnes hospital, st. louis, between 1 september 1988 and 1 september 1989 were retrospectively reviewed. one hundred six candidemic patients were identified, representing 0.5% of all medical and surgical discharges and 0.33% of total patient discharges. these percentages represent a 20-fold increase in the incidence of candidemia at our hospital in comparison with that during 1976-1979. candida alb ... | 1992 | 1520786 |
| purification and characterization of secretory proteinase of candida albicans. | proteolytic activity of medically important yeasts was tested in both ycb-bsa agar and medium. all of 134 strains of candida albicans, 13 of 18 strains of candida tropicalis and 11 of 18 strains of candida parapsilosis had this activity, while none of 52 candida glabrata strains or of 11 cryptococcus neoformans strains tested had proteolytic activity. strains of c. albicans fell into five groups based on the level and time-course of in vitro proteinase productivity. five strains randomly selecte ... | 1992 | 1522813 |
| outbreak of candida bloodstream infections associated with retrograde medication administration in a neonatal intensive care unit. | an outbreak of candidemia involving five infants receiving total parenteral nutrition in the neonatal intensive care unit was investigated. cultures of the intravenous fluids demonstrated that the retrograde medication syringe fluids were significantly more likely to be contaminated with candida than were other fluids being administered to the infants (p less than 0.001). candidemia was significantly associated with total parenteral nutrition (p = 0.04) and retrograde medication administration ( ... | 1992 | 1538298 |
| [a case report of candida prosthetic endocarditis: an autopsy review]. | most of the increasing numbers of cases of candida endocarditis have developed after cardiac surgery. we report a case of candida parapsilosis endocarditis after mitral valve replacement in a patient with no predisposing factors. in this report we mainly examined the pathological findings in this patient with postmortem examination. a woman, age 55, underwent valve replacement with a björk-shiley prosthesis for mitral stenosis. the spike fever occurred on the 22nd postoperative day and candida p ... | 1992 | 1564811 |
| treatment of candidemia in critically ill surgical patients with intravenous fluconazole. | six nonneutropenic, critically ill patients with candidemia who underwent surgery were treated with intravenous fluconazole, a new, nontoxic triazole derivative. the portal of entry for candida species could be demonstrated for four patients (the peritoneal cavity in two and a central venous catheter in two). there were three cases of fungemia due to candida albicans; two cases were due to candida tropicalis, and one case was due to candida parapsilosis. fluconazole was administered to these pat ... | 1992 | 1576294 |
| saddle embolism complicating candida parapsilosis aortic valve endocarditis: cure with aortic valve replacement and prompt extraction of multiple mycotic emboli. | | 1992 | 1619717 |
| phagocytosis of candida parapsilosis by polymorphonuclear leukocytes. | the authors present a brief case report on an unusual entity. this rare phenomenon observed in a peripheral smear is worth noting. neutrophils and rare eosinophils show intracellular fungal cells; the size, shape, and budding are consistent with candida parapsilosis. | 1992 | 1635677 |
| surveillance of nosocomial fungal infections in a burn care unit. | a survey was conducted to trace the source of nosocomial fungal infections in the burn care unit of nehru hospital, chandigarh, india, by collection of samples from wounds of 25 severely burnt patients and their surroundings. the environmental sampling revealed predominant fungal contamination by dematiceous hyphomycetes, aspergilli, penicillium, fusarium and yeasts (candida albicans, candida tropicalis, candida krusei, candida parapsilosis), whereas the colonising or invading fungi from the pat ... | 1992 | 1644487 |
| [in vitro antifungal activity of itraconazole, a new triazole antifungal agent, against clinical isolates from patients with systemic mycoses]. | the in vitro antifungal activity of itraconazole (itz), a new oral triazole antifungal agent, against clinical isolates from patients with systemic mycoses were compared with those of existing systemic antifungals, viz. ketoconazole (kcz), miconazole or amphotericin b. the studies were performed with 65 isolates of pathogenic yeasts and 13 isolates of aspergillus spp. using the agar dilution method on casitone agar. itz showed the most potent antifungal activities against isolates of pathogenic ... | 1991 | 1652654 |
| in vitro comparison of cilofungin alone and in combination with other antifungal agents against clinical isolates of candida species. | cilofungin, a lipopeptide antifungal agent, was tested for in vitro activity alone and in combination with ketoconazole, itraconazole, flucytosine and amphotericin b against 102 clinical isolates of candida species. at 48 hours all isolates of candida albicans, candida tropicalis, candida paratropicalis and candida glabrata were inhibited by less than or equal to 5 meg/ml of cilofungin. in contrast, the mic90 for candida krusei was 10 mcg/ml and for candida parapsilosis greater than 40 mcg/ml. t ... | 1991 | 1655435 |
| kinetics and requirements for activation of macrophages for fungicidal activity: effect of protein synthesis inhibitors and immunosuppressants on activation and fungicidal mechanism. | peritoneal-and pulmonary macrophages can be activated in vitro with lymphokines (lk) or ifn-gamma, without exogenous lipopolysaccharide, for fungicidal activity against several pathogenic fungi. however, neither the biochemical nor metabolic events of the activation process or of the effector phase have been defined. in the present work we sought to elucidate these events with time-course studies using inhibitors of protein synthesis as well as immunosuppressive agents. we found that protein syn ... | 1991 | 1712253 |
| hsp 90, yeasts and corynebacterium jeikeium. | recovery from disseminated candidosis is associated with seroconversion to a 47 kda breakdown product of the heat shock protein (hsp) 90 of candida albicans. cloning, sequencing and epitope mapping has allowed the delineation of the immunodominant epitopes lkvirknivkkmie and stdepagesa. monoclonal and polyclonal antibodies specific to these epitopes are used to show that all strains of c. albicans tested produce hsp 90 in both the yeast and mycelial phases. homologous proteins are demonstrated i ... | 1991 | 1718769 |
| comparison of the in vitro antifungal activity of free and liposome-encapsulated amphotericin b. | one hundred and four pathogenic yeast isolates (32 candida albicans, 20 candida tropicalis, 20 candida parapsilosis and 32 cryptococcus neoformans) and 21 mould isolates (13 aspergillus spp. and eight fusarium spp.), most of which were isolated from patients with cancer, were tested for susceptibility to free amphotericin b and a small unilamellar liposomal formulation of amphotericin b using a microbroth dilution method. minimal fungicidal concentrations were also determined for candida spp. an ... | 1991 | 1748123 |
| characterization of a monoclonal antibody (rj5) against the immunodominant 41-kd antigen of candida albicans. | a 41-kd component of candida albicans was identified to be the major antigen radioimmunoprecipitated by antibodies with increased titers in the sera of patients with invasive candidiasis. a mouse monoclonal antibody (rj5) was generated which, by immunoblotting, showed positive reactivity to the immunoprecipitated 41-kd component. by two-dimensional gel electrophoresis and immunoblotting, moab rj5 was shown to react with different isoforms of the 41-kd component with pi values from 6.1 to 6.9. fu ... | 1991 | 1769743 |
| [endocarditis caused by candida parapsilosis after total correction of tetralogy of fallot. medico-surgical treatment]. | three children with candida parapsilosis endocarditis after total surgical correction for tetralogy of fallot, are reported. blood cultures became negative in one child with amphotericin-b and in the other two with ketoconazole, before reoperation for septal patch replacement. oral therapy with ketoconazole continued for a total of 24 months, and during a mean follow-up of 36 months no side effects or reinfection occurred. medical and surgical conjoined therapy, with surgical timing decided on c ... | 1991 | 1807094 |
| long-term laboratory preservation of pathogenic yeasts in water. | a total of 1583 yeast isolates, mostly candida albicans, has been maintained under sterile distilled water for periods ranging from 1 to 18 years. overall, 71 (4.5%) of the isolates were not recoverable at 37 degrees c. survival of the yeasts was 97% in the first 5 years and 96% after 10 years. isolates of candida krusei and saccharomyces cerevisiae were particularly unlikely to survive storage in water and these species should be preserved by other means if they are to be kept for more than a f ... | 1991 | 1815033 |
| isolation of the atp synthase subunit 6 and sequence of the mitochondrial atp6 gene of the yeast candida parapsilosis. | the mitochondrially translated product called subunit 6 was extracted from the yeast candida parapsilosis mitochondria using an organic solvent mixture and purified by reverse-phase hplc. the partial n-terminal sequence of subunit 6 reveals a post-translational cleavage site as in saccharomyces cerevisiae. the structural mitochondrial gene atp6 was isolated form a mitochondrial dna library using the oligonucleotide probe procedure. the gene and the surrounding regions were cloned into m13tg130 a ... | 1991 | 1826652 |
| mechanisms of host defense against candida species. ii. biochemical basis for the killing of candida by mononuclear phagocytes. | we studied the biochemical basis of candidacidal activity by comparing the killing of candida albicans, a serious pathogen, and candida parapsilosis, a low-grade pathogen, by human monocytes (mo) and monocyte-derived macrophages. mo killed c. parapsilosis significantly better than c. albicans. the two species triggered the respiratory burst and release of myeloperoxidase (mpo) and beta-glucuronidase in mo to an equivalent extent. in contrast to mo, macrophages killed both species to an equivalen ... | 1991 | 1849938 |
| comparison study of broth macrodilution and microdilution antifungal susceptibility tests. | an evaluation of broth dilution antifungal susceptibility tests was performed by determining both the micro- and macrodilution mics of amphotericin b, flucytosine, fluconazole, ketoconazole, and cilofungin against 38 isolates of candida albicans, candida lusitaniae, candida parapsilosis, candida tropicalis, cryptococcus neoformans, and torulopsis glabrata. the following preliminary antifungal working group recommendations of the national committee for clinical laboratory standards for broth macr ... | 1991 | 1864923 |
| molecular cloning of the secretory acid proteinase gene from candida albicans and its use as a species-specific probe. | candida albicans secretes an acid proteinase when grown with a protein as a sole nitrogen source. the gene encoding this proteinase was isolated from a genomic expression library of c. albicans constructed in lambda gt11 by screening with antiproteinase antibodies. the affinity-purified antibodies used to verify the clones are monspecific; these do not cross-react with any other protein in the culture supernatants or crude extracts of c. albicans but strongly react with fusion proteins encoded b ... | 1991 | 1879921 |
| successful medical treatment of presumed candida endocarditis in critically ill infants. | few infants have been reported who survived fungal endocarditis; all have required both surgical and intensive antifungal therapy. we describe three infants, two weighing less than 1000 gm, who survived candida endocarditis without surgery. two had candida parapsilosis, an agent not previously reported as a cause of neonatal endocarditis. all three infants were treated with amphotericin b and 5-flucytosine. despite administration of 44, 38, and 48 mg/kg amphotericin b, respectively, no nephrotox ... | 1991 | 1880666 |
| biochemical studies carried out on different groups of candida parapsilosis and candida rhagii strains by comparing some cellular and mitochondrial activities. | a comparative biochemical study was performed on some strains of candida rhagii and on strains belonging to different subgroups of candida parapsilosis. measurements of alcohol dehydrogenase activity, resistance to drugs and occurrence of an alternative pathway enabled us to confirm the classification between several subgroups within the c. parapsilosis species. | 1991 | 1883228 |
| synthesis and antifungal activity of some new benzimidazole derivatives. | synthesis and antifungal evaluation of 5-ethoxycarbonyl-2-(substituted-benzyl or phenoxymethyl)benzimidazoles are reported. structures of the compounds were elucidated with ir-, 1h-nmr-, 13c-nmr-, mass-spectra and elemental analysis. preliminary results show that none of the synthesized benzimidazole derivatives has antifungal activity at the concentration of 100 micrograms/ml against candida parapsilosis, candida stellatoidea, and candida pseudotropicalis. | 1991 | 1888265 |
| mechanisms of host defense against candida species. i. phagocytosis by monocytes and monocyte-derived macrophages. | we studied the biochemical basis of phagocytosis of candida albicans, a serious pathogen, and candida parapsilosis, which is rarely pathogenic, by human monocytes (mo) and monocyte-derived macrophages (mdm). optimal phagocytosis of both species by mo required the presence of extracellular ca2+ and opsonization through both the classic and alternative complement pathways. serum-opsonized candida were ingested equally by mo and mdm; unopsonized candida were phagocytosed only by macrophages, and up ... | 1991 | 1901885 |
| [candida parapsilosis infection as a complication of long-term parenteral nutrition]. | in case of short bowel syndrome in infancy the total parenteral nutrition was complicated by catheter-associated candida parapsilosis septicemia based on generalized enterococci infection. specific problems in antifungal treatment are discussed. | 1991 | 1905364 |
| [laboratory and clinical investigation of lysis centrifugation blood culture method for fungemia]. | we compared the lysis centrifugation blood culture system using isolator (du pont) to the conventional blood culture bottle using bcb system (roch), and the following results were obtained. in the investigation of experimental fungemia made by human blood and candida albicans, the organism was detected 9/12 after 1 day and 11/12 after 3 days by isolator, although the organism was detected 3/12 after 3 days and 11/12 after 6 days by the culture bottle system. in the experimental fungemia of candi ... | 1991 | 1919115 |
| identification of oral yeasts by polyacrylamide gel electrophoresis. | protein profiles of sonicated cells for 9 species of yeast isolated from oral samples were obtained by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page), and visualized with a silver stain. the profiles obtained on 12% acrylamide gels were distinct, and characteristic for 6 species of candida, and torulopsis glabrata, yarrowia lipolytica, and saccharomyces cerevisiae. using this method, 79 fresh isolates of yeasts from saliva samples were identified; 58 as candida albicans, 9 ... | 1991 | 1945503 |
| fungemia: analysis of 43 cases. | this report reviews the cases of 43 patients with 48 episodes of fungemia, and examines the clinical significance of fungemia and the results of treatment. all episodes were nosocomial infections. candida albicans (60.4%), candida parapsilosis (16.7%), and candida tropicals (14.6%) were the most common fungal pathogens isolated from blood cultures. patients with candida albicans had a better survival rate than those with other species (p = 0.011). polymicrobial fungemia was noted in 5 patients ( ... | 1990 | 1981773 |
| delayed-onset pseudophakic endophthalmitis. | we reviewed 19 cases of delayed-onset pseudophakic endophthalmitis in which diagnostic cultures were performed at one month or more after cataract extraction with posterior chamber intraocular lens implantation. we isolated four different organisms in these 19 cases: 12 propionibacterium species (63%), three candida parapsilosis (16%), three staphylococcus epidermidis (16%), and one corynebacterium species (5%). because of the unusual delayed-onset features of these cases and the retrospective n ... | 1991 | 1992736 |
| the antimycin-a-insensitive respiratory pathway of candida parapsilosis: evidence for a second quinone involved specifically in its functioning. | the involvement of a quinone in the antimycin a-insensitive electron transfer from nadh-dehydrogenase to cytochrome c via the alternative respiratory chain of candida parapsilosis, by-passing complex ii, has been studied. after a partial extraction of quinones, the residual respiration was fully antimycin-a-sensitive, but reincorporation of the organic extract partially restored an antimycin a-insensitive respiration. analysis of quinone content by hplc, after purification by thin-layer chromato ... | 1991 | 2009273 |
| in vitro susceptibility of 119 yeast isolates to fluconazole, 5-fluorocytosine, amphotericin b and ketoconazole. | the in vitro activity of fluconazole was tested against 13 yeast species (119 strains) isolated from clinical specimens during a 3-month period. for comparative purposes, three other antifungal compounds (5-fluorocytosine, amphotericin b and ketoconazole) were also tested. the tests were carried out using a microautomated method previously developed in our laboratory. the method allowed us to determine the minimum inhibitory concentration (mic) of the four antifungal drugs used. for each of the ... | 1991 | 2013239 |
| fluconazole in the treatment of candidiasis in immunocompromised children. | fluconazole, a new triazole derivative, was evaluated in a pilot study of 34 episodes of candidiasis in 24 children. all the patients had predisposing conditions, such as human immunodeficiency virus infection, cancer, organ or bone marrow transplantation, neonatal age and malnutrition, and obstructive uropathy. the drug was administered at 6 mg/kg (body weight) once daily either orally or intravenously. two patients with fungemia due to candida parapsilosis required an increased dosage of 12 mg ... | 1991 | 2024968 |
| dna fingerprinting and electrophoretic karyotype of environmental and clinical isolates of candida parapsilosis. | the endonuclease restriction pattern (dna fingerprinting) and the electrophoretic karyotype of 16 candida parapsilosis isolates from environmental and clinical sources were investigated. dna from both whole cells and separated mitochondria was digested with enzymes, including ecori, bamhi, kpni, bglii, hpaii, pvuii, and hindiii. regardless of their source and pathogenic properties, all isolates showed a uniform, reproducible, and overlapping whole-cell dna fingerprinting with each endonuclease d ... | 1991 | 2056059 |
| a case of candida parapsilosis endocarditis. | the authors report a case of candida parapsilosis endocarditis in a non-drug-addicted young patient who, 6 months before the manifestation of endocarditis, was submitted to cardiac surgery. this is the first report from greece and the second found in the accessible literature. | 1990 | 2093837 |
| potential of bifonazole for direct lethal action. | time-kill type experiments were designed to assess the potential of bifonazole, a topical antifungal imidazole-containing drug, for its capacity to exert growth phase-dependent direct physicochemical lethal action against opportunistic yeast pathogens. test organisms included two strains of candida albicans and one of candida parapsilosis. in contrast to the reference imidazole miconazole, which rapidly killed yeast cells in late lag to early logarithmic phase at concentrations between 10(-5) an ... | 1990 | 2101777 |
| immunochemical and structural analysis of the cell wall mannan as the basis of the taxonomic reidentification of a yeast strain. | the immunochemical properties and structural features of d-mannans from two candida parapsilosis strains were studied. weak cross-reactivity of d-mannans with antisera produced to c. parapsilosis strains was observed, as well as significant differences in the mannans structures were found by means of methylation analysis, acetolysis and 1h-nmr spectroscopy. in view of the discrepancies found, new taxonomic identification of one strain was carried out. on the basis of assimilation of potassium ni ... | 1990 | 2129042 |
| [candida parapsilosis esophagitis in hiv infected patient]. | | 1990 | 2135588 |
| cloning and sequencing of a fragment of the linear mitochondrial dna of the yeast candida parapsilosis supporting genes encoding subunit 8 of fo atp synthase and a putative t-rna(pro). | | 1990 | 2143015 |
| cytomegalovirus infection in a neonatal intensive care unit. subsequent morbidity and mortality of seropositive infants. | in a study of blood transfusion and cytomegalovirus (cmv) infection in 385 infants, 5 (8%) of 60 seropositive infants with birthweights less than or equal to 1250 g acquired cmv. four infants had become seronegative by the time of viral excretion and demonstrated significant morbidity with one death. morbidity included variant (atypical) lymphocytosis, thrombocytopenia, staphylococcal epidermidis and candida parapsilosis infections, and respiratory deterioration. interestingly, the infant who ex ... | 1990 | 2156031 |
| [oxygen radical generation of murine alveolar macrophages]. | the respiratory burst of murine alveolar macrophages (am) was compared with that of peritoneal macrophages (pm). superoxide anion (o2-) released from resident am was similar to that of resident pm. that is, resident am or pm exposed to phorbol myristate acetate (pma) released only a small amount of o2-, whereas both macrophages released a large amount of o2- when stimulated with zymosan particles. am as well as pm obtained from mice injected with mycobacterium bovis bcg 3 weeks previously (abbre ... | 1990 | 2170730 |
| efficacy of fluconazole in prophylaxis and treatment of experimental candida endocarditis. | the efficacy of fluconazole, a bis-triazole antifungal agent, for prophylaxis and treatment of endocarditis due to candida albicans and candida parapsilosis is assessed in a rabbit model. fourteen daily injections of fluconazole at doses of 20 and 10 mg/kg of body weight eradicated c. albicans and c. parapsilosis, respectively, from the cardiac vegetations in all animals tested. amphotericin b (3 mg/kg) and flucytosine (35 mg/kg) both singly and in combination failed to achieve eradication in 10 ... | 1990 | 2184507 |
| characterization of the mycoflora from oral mucosal surfaces of some hiv-infected patients. | oral mucosal surfaces from 54 patients seropositive for human immunodeficiency virus (hiv) were assayed for the presence of cultivable yeasts. oral colonization with candida albicans, represented by 6 biotypes, was evident in 35 persons. the closely related variant, candida stellatoidea, was found in 3 patients. single isolates of candida parapsilosis, candida glabrata, candida tropicalis, and candida paratropicalis were also identified. one patient harbored a population of saccharomyces cerevis ... | 1990 | 2192330 |
| discriminant analysis of cellular fatty acids of candida species, torulopsis glabrata, and cryptococcus neoformans determined by gas-liquid chromatography. | we used discriminant analysis of cellular fatty acid compositions determined by gas-liquid chromatography to differentiate yeastlike fungi (a total of 190 strains; including 37 candida albicans strains, 21 candida krusei strains, 13 candida guilliermondii strains, 37 candida tropicalis strains, 10 candida pseudotropicalis strains, 24 candida parapsilosis strains, 32 torulopsis glabrata strains, and 16 cryptococcus neoformans strains). previous results with a standard strain of c. albicans indica ... | 1990 | 2199515 |
| experimental pathogenicity and acid proteinase secretion of vaginal isolates of candida parapsilosis. | isolates of candida parapsilosis from women with or without candidal vaginitis were compared for their ability to produce secretory aspartate (acid) proteinase and their virulence for normal or cyclophosphamide-immunodepressed mice. although all isolates were strongly proteolytic in vitro, only those from candidosis-affected subjects were appreciably pathogenic for neutropenic mice. in these animals, organ invasion was monitored after challenge with representative isolates of each category. the ... | 1990 | 2199657 |
| in vitro activity of the new semi-synthetic polypeptide cilofungin (ly121019) against aspergillus and candida species. | the in vitro activity of cilofungin (ly121019), a new semi-synthetic antifungal agent was evaluated. potent activity was seen against candida albicans and candida tropicalis, with almost identical mic and mfc results, whereas no activity was seen against any isolates of candida parapsilosis or three aspergillus spp. however, mics were dependent on medium and test conditions chosen. it is concluded that cilofungin has good activity against some medically important yeasts in vitro, and that its in ... | 1990 | 2226501 |
| evaluation of the updated vitek yeast identification data base. | using 398 isolates of yeasts and yeastlike fungi comprising 9 genera and 26 species, as well as the hyphomycete geotrichum candidum and the achlorophyllous alga prototheca wickerhamii, we compared the api 20c yeast identification system with the modified vitek yeast identification system with an expanded data base. we found 11 discrepancies between the two systems: five (1.3%) of the isolates (blastoschizomyces capitatus, 1; candida albicans, 1; hansenula anomala, 1; rhodotorula minuta, 2) had b ... | 1990 | 2229376 |
| [identification and susceptibility of clinically isolated yeast-like fungi]. | we studied the identification and susceptibility of clinically isolated yeast-like fungi at showa university hospital from april 1988 to march 1989. clinically significant of yeast-like fungi were observed in 7.1% of specimens from outpatients, 13.0% of inpatients. in both outpatients and inpatients, yeast-like fungi were isolated mainly from sputum and urine. but, one third of them were considered as non-pathogenic and not identified. the species of isolates were, candida albicans 57%, candida ... | 1990 | 2232256 |
| mitochondrial phosphate transport. n-ethylmaleimide insensitivity correlates with absence of beef heart-like cys42 from the saccharomyces cerevisiae phosphate transport protein. | the mitochondrial phosphate transport protein (ptp) has been purified in a reconstitutively active form from saccharomyces cerevisiae and candida parapsilosis. adp/atp carriers that copurify have been identified. the ptp from s. cerevisiae migrates as a single band (35 kda) in sodium dodecyl sulfate gels with the same mobility as the n-ethylmaleimide-alkylated beef heart ptp. it does not cross-react with anti-sera against beef heart ptp. the cnbr peptide maps of the yeast and beef proteins are v ... | 1990 | 2246257 |
| [ulcerative colitis and fungemia caused by candida parapsilosis]. | | 1990 | 2247689 |
| persistent colonization of carbon dioxide incubators with candida parapsilosis. | recurrent contamination of bacteriological specimens with candida parapsilosis led to epidemiological investigations which indicated persistent colonization of carbon dioxide incubators as the most likely source. changes in the technical arrangements and institution of a meticulous cleansing protocol eliminated contamination of specimens but not colonization of the incubators. tests for tolerance of 17% nacl and survival at 50 degrees c, and sds-page analysis of crude cell extracts allowed discr ... | 1990 | 2261919 |
| cell-constituent polyamines in candida species and new biotyping of candida albicans, candida tropicalis and candida parapsilosis strains. | intracellular amines from three candida species were extracted and chemically derivatized by a modification of the seiler procedure. the results of qualitative determinations of 13 amines in 20 strains each of candida albicans, candida tropicalis and candida parapsilosis are presented. this report is the first to describe the detection of amines other than the classical spermine, spermidine, putrescine and cadaverine in yeasts and fungi. characteristic profiles due to the presence or absence of ... | 1990 | 2269908 |
| in vitro susceptibility testing of candida isolates from clinical specimens to four antifungal agents. | a total of 231 isolates of candida species including 163 of candida albicans (132 of serotype a and 31 of serotype b), 42 of candida tropicalis, 17 of candida glabrata, 7 of candida parapsilosis and 2 of candida krusei were collected from clinical specimens in two medical centers, one in japan and the other in the united states. the in vitro antifungal activities of amphotericin b, 5-fluorocytosine, miconazole and fluconazole were evaluated for the above isolates by means of a photo-read broth m ... | 1990 | 2292203 |
| [severe infection caused by candida parapsilosis in an infant]. | three cases of serious infections due to candida parapsilosis in infants are reported. two patients are children exposed to abdominal surgery, parenteral nutrition and antibiotic treatment, who developed catheter-associated sepsis with successful response to change of catheter and intravenous amphotericin b, despite one of the patients showed a relapse some weeks after. third patient, a hydrocephalic child with external ventricular shunt, developed cerebrospinal fluid infection without response ... | 1990 | 2327668 |
| [sepsis caused by candida parapsilosis. joint and lung involvement in 2 patients with acute leukemia]. | sepsis due to candida parapsilosis with involvement of the joints and the lungs, respectively, is reported in two patients with acute leukemia. the first patient had ankle arthritis 72 days after an allogenic bone marrow transplant for acute lymphoblastic leukemia. the second patient had pneumonia with cavitation during pancytopenia after chemotherapy for acute monocytic leukemia. in both cases, c. parapsilosis sepsis responded to therapy with amphotericin b, associated with miconazole in the fi ... | 1990 | 2329845 |