| microbial biodegradation of cellophase. | the microbial biodegradation of cellophane (u.c.b.--division sidac) was studied. preliminary experiments with pure cultures of seven cellulolytic microorganisms (aspergillus sp., penicillium sp., chaetomium crispatum, ch. globosum, sclerotium rolfsii and two actinomycetes) revealed that the substrate as such was very recalcitrant, probably due to the occurrence of insoluble coating agents. therefore, mixed cultures of the above mentioned cellulolytic microorganisms were used as inoculum. the cel ... | 1978 | 29381 |
| new microbial growth factor. | a screening procedure was used to isolate from soil a penicillium sp., two bacterial isolates, and a streptomyces sp. that produced a new microbial growth factor. this factor was an absolute growth requirement for three soil bacteria. the penicillium sp. and one of the bacteria requiring the factor, an arthrobacter sp., were selected for more extensive study concerning the production and characteristics of the growth factor. it did not seem to be related to the siderochromes. it was not present ... | 1977 | 327929 |
| exposure of rabbits to spores of aspergillus fumigatus or penicillium sp: survival of fungi and microscopic changes in the respiratory and gastrointestinal tracts. | rabbits were exposed to spores of aspergillus fumigatus by 1 of 2 routes: exposure to aerosols of dry spores or introduction of liquid suspensions of spores directly into the stomach. rabbits also were exposed to aerosols containing spores of a penicillium sp. cultural and microscopic examinations of tissues from the respiratory and gastrointestinal tracts indicated fungi were distributed throughout the gastrointestinal tract of the rabbits within 1 hour after exposure to aerosols of a fumigatus ... | 1979 | 393142 |
| primary structure of a nuclease (nuclease pa3) from a penicillium sp. | the complete primary structure of a nuclease from a penicillium sp. [nuclease pa3 (kazama et al., chem. pharm. bull., 38, 3081 (1990)] was determined. the sequencing was done by analysis of the peptides generated by digestion of reduced and carboxymethylated nuclease pa3 (rcm nuclease pa3) with lysylendopeptidase, and by digestion with staphylococcal v8 protease or chemical cleavage with brcn. it consisted of 270 amino acid residues and carbohydrate moieties attached to the 92nd, 138th, 184th, a ... | 1991 | 1369324 |
| mycotic keratitis in nigeria. a study of 21 cases. | a clinical and mycological study of 21 cases of mycotic keratitis, a clinical entity not yet reported from nigeria or west africa, showed that fusarium solani was the predominant aetiological agent. it was isolated from 12 cases. four of the remaining nine cases were caused by aspergillus fumigatus, one by a. flavus, two by penicillium citrinum, and one each by p. expansum and penicillium sp. all the 12 isolates of f. solani grew well at 37 degrees c and survived at 40 degrees c. two cases, one ... | 1976 | 791355 |
| role of opportunistic fungi in ocular infections in nigeria. | the importance of opportunistic fungal pathogens in causing ocular infections is emphasized. a study was conducted over a period of 4 years (1974--1977) to investigate the role of opportunistic fungi in causing mycotic keratitis and to elucidate certain aspects of epidemiology of this disease in nigeria. fifty-nine cases of corneal ulcers of suspected mycotic etiology were investigated. fungal etiology was confirmed in 42 of these cases. the predominant etiological agent was fusarium solani in 1 ... | 1978 | 745623 |
| an imidazole derivative (econazole) as an antifungal agent in cell culture systems. | econazole, an imidazole derivative, was tested as an antifungal agent in different cell culture systems. in comparison with fungizone, econazole has the following advantageous properties: higher stability, higher solubility, better antifungal activity against contaminants of cell cultures and a wider range between minimal inhibitory to cytotoxic concentration with aspergillus fumigatus, candida albicans and penicillium sp., activity against gram-positive bacteria and lower price. econazole exert ... | 1979 | 521035 |
| culture medium alkalinization by dermatophyes. (influence of time and temperature of incubation). | 95 dermatophyte strains (12 of trichophyton mentagrophytes, 12 of t. tonsurans, 11 of t. rubrum, 12 of t. megninii, 12 of t. violaceum, 2 of t. schoenleinii, 1 of t. soudanense, 12 of m. canis, 8 of microsporum gypseum, 1 of m. ferrugineum and 12 of epidermphoyton floccosum). 1 of aspergillus niger, 1 of a. ochraceus, 1 of paecilomyces sp., 1 of penicillium sp. and 1 of candida albicans were grown in sabouraud liquid medium for the study of ph variation over 6 weeks at room temperature and after ... | 1975 | 238130 |
| morphology and ultrastructure of a penicillium sp. grown on n-hexadecane or peptone. | the morphology and ultrastructure of a penicillium sp. grown on n-hexadecane or on peptone in shake-culture were compared using transmission and scanning electron microscopy. the fungus grew as hollow mycelial balls surrounding individual hydrocarbon droplets on n-hexadecane and as solid mycelial balls on peptone. a dense layer of fungal mycelium that showed irregular forms, fusion, and increase in hyphal size formed at the hydrocarbon-water interface. inclusions were present in the hexadecane-g ... | 1976 | 180883 |
| effect of various nitrogen salts in beet pulp medium on polygalacturonase activity of penicillium sp. 7/4b/ei 1 mutant. | the highest pg activity was obtained in beet pulp with (nh4)2hpo4 in amount equivalent to 0.14--0.28% n after 7 days of growth; at optimal concentration, (nh4)2hpo4 did not influence the biomass production, but increased the ph of the culture media to above 6.0. the pg was an extracellular enzyme, acting mainly on highly esterified pectin. the attack was of a random manner, characteristic for the endo-enzymes. the enzyme was active at temperature 20 degrees c--40 degrees c and ph 5.0--6.0. | 1978 | 81597 |
| bioconversion of wheat straw and wheat straw components into single-cell protein. | several fungi (aspergillus niger, a. terreus, cochliobolus specifer, myrothecium verrucaria, rhizoctonia solani, spicaria fusispora, penicillium sp., and gliocladium sp.) were isolated from decomposing wheat straw and tested for their ability to utilize whole straw and its components, holocellulose (hemicellulose and cellulose) and cellulose, for the production of single-cell protein (scp). it was found that c. specifer was the most efficient fungus for protein synthesis with the three substrate ... | 1979 | 38899 |
| comparative study of the properties of lipase of microbial origin. | a comparative study of properties of lipases of microbial origin has shown that the ph optimum of the enzymes from geotrichum asteroides and penicillium sp. is at ph 7.5 and 5.0, respectively. lipase from geotrichum asteroides appears more resistant to high temperatures and ph changes than the enzyme from penicillium sp. both enzymes split selectively vegetable oils, especially cotton and sunflower oils. na cholate and deoxycholate at a concentration of 0.05-0.4% act as hydrolysis activators, pa ... | 1976 | 17110 |
| prevalence of basidiospore allergy in the pacific northwest. | mold spore-induced respiratory allergy has been incompletely studied, and only a limited number of fungi imperfecti are well established as aeroallergens. basidiomycetes, a complex and common group of fungi, which include mushrooms, rusts, smuts, brackets, and puffballs, have not been well studied. although basidiospores can be present in high atmospheric concentrations, little is known of their aeroallergen potential. to examine this question, we performed skin prick and rasts in 33 adult resid ... | 1988 | 3204251 |
| growth and toxin production by clostridium botulinum in moldy tomato juice. | tomato juice inoculated with cladosporium sp. or penicillium sp. developed ph gradients with the upper portions near the mold mats having ph values near neutrality and the lower portions remaining more acid. clostridium botulinum spores in these moldy tomato juices germinated, grew out, and produced toxin. | 1976 | 10844 |
| constitutive synthesis of endopolymethylgalacturonase by the microscopic fungus, penicillium sp. 24p. | | 1976 | 8162 |
| [antagonism in vitro among phytopathogenic and saprobic fungi from horticultural soils]. | two methods were tested in order to determine the existence of in vitro antagonism among saprobic and pathogenic fungi. these microorganisms were the most common isolates from horticultural soils of la plata (buenos aires). trichoderma harzianum; t. koningii and penicillium sp. were antagonistic to all the pathogenic fungi tested, fusarium solani; f. oxysporum; alternaria solani; colletotrichum sp. and sclerotium rolfsii spicaria sp., paecilomyces sp. and chaetomiun sp. were antagonistic only to ... | 1990 | 2287718 |
| the structures of atpenins a4, a5 and b, new antifungal antibiotics produced by penicillium sp. | the structures of atpenins a4, a5 and b, new antifungal antibiotics produced by penicillium sp., have been deduced to be i, ii and iii, respectively, on the basis of spectroscopic and 1h and 13c nmr spectral data. the molecular structure of atpenin a4 with absolute configurations was finally confirmed to be 2's,4's,5's-5,6-dimethoxy-4-hydroxy-5'-chloro-2',4'- dimethyl-1'-oxoheptyl-2-hydroxypyridine (i') by the single crystal x-ray crystallographic analysis. the absolute configurations of atpenin ... | 1990 | 2276974 |
| mechanism of action of atpenin b on raji cells. | atpenin b, a new antifungal antibiotic produced by penicillium sp. fo-125, inhibited the growth of raji cells (ic50, 30 microm). the incorporation of [14c]leucine and [3h]thymidine into raji cells was inhibited by atpenin b with ic50 values of 0.10 and 0.12 microm, respectively. the incorporation of [14c]palmitate into the cells was not inhibited but its incorporation into lipid fractions was inhibited by atpenin b (ic50, 0.13-0.24 microm). studies on the site of atpenin b action demonstrated th ... | 1990 | 2211368 |
| invasive pulmonary penicilliosis: successful therapy with amphotericin b. | we have described a patient with invasive pulmonary penicilliosis, documented by thoracotomy and cured with amphotericin b. penicillium sp isolates in immunosuppressed patients should not be disregarded without a thorough investigation, especially if normally sterile sites are involved. amphotericin b therapy may be successful, especially if accompanied by a reversal or moderation of immunosuppression. | 1990 | 2192469 |
| characterization of an aggregated polymer from penicillium sp. (pb-73 strain). | 1. we describe a polymeric form of magnesium ammonium phosphate associated with linoleic acid and a basic protein produced by penicillium sp (strain pb-73). 2. chemical and physical data suggest a structure characterized as an aggregated polymeric form of protein magnesium ammonium phospholinoleate anhydride. 3. the aggregated polymer has an approximate molecular weight of 316 kda and a phosphate/magnesium ratio of 2.34. | 1990 | 2136563 |
| purification and characterization of a nuclease (3'-nucleotidase) from a penicillium sp. | a nuclease (3'-nucleotidase) similar to p1 nuclease from penicillium citrinum was purified from a commercial digestive from a penicillium sp. the activity of the nuclease (pa) was separated to three fractions by diethylaminoethyl-toyopearl 650m column chromatography, in total yield of 10%. the apparent molecular weight of these three nucleases, pa1, pa2 and pa3 was 35000, 33000, and 32000, respectively. all of them were homogeneous so far as checked by sodium dodecyl sulfate slab gel electrophor ... | 1990 | 1964878 |
| evolution of trimethylarsine by a penicillium sp. isolated from agricultural evaporation pond water. | arsenicals are used in agriculture as pesticides and defoliants. in the central valley of california, arsenic is present in soil at naturally high concentrations, being derived from marine sedimentary parent material of the coastal range. due to intense agricultural irrigation, soluble arsenic is leached from the soil and accumulates in evaporation ponds where it may pose an environmental threat to the waterfowl and wildlife. a penicillium sp. isolated from evaporation pond water was found to be ... | 1991 | 1925518 |
| a new series of natural antifungals that inhibit p450 lanosterol c-14 demethylase. ii. mode of action. | from a penicillium sp. we identified a new series of antifungals having a tetrahydropyran skeleton with an alkenyl side chain. we elucidated the mode of action of ro 09-1470, the most active compound of the series. treatment of candida albicans with the compound caused an accumulation of c-14 methyl intermediates of ergosterol at concentrations of which no significant interference with the biosyntheses of other macromolecules and respiration was observed. p450 lanosterol c-14 demethylase (p450(1 ... | 1992 | 1556007 |
| a new series of natural antifungals that inhibit p450 lanosterol c-14 demethylase. i. taxonomy, fermentation, isolation and structural elucidation. | a new series of antifungal antibiotics, ro 09-1470 and its 6 congeners were isolated from the fermentation broth of penicillium sp. nr6564. their structures were determined as tetrahydropyran derivatives with an alkenyl side chain on the basis of their spectroscopic and physico-chemical properties. among these compounds, ro 09-1470 and ro 09-1545 possessing a glycyl n-substituted glycyl ester residue had high antifungal activity. ro 09-1469, one of the congeners, was found in the fermentation br ... | 1992 | 1556006 |
| effect of moisture content on the microbial activity in jp-5 fuel oil. | the water solubility of jp-5 fuel oil was found to be proportional to the reciprocal of absolute temperature from 0 degree c to 60 degrees c. water in the fuel oil would become condensed once the temperature was shifted from a high temperature to low temperature. during the storage, condensed water was precipitated in the bottom of the tank. both the static and the dynamic dehumidification processes with molecular sieve could reduce the moisture content of fuel oil to less than 5 ppm. however, p ... | 1992 | 1342639 |
| [inhibitory effects of organic acids and salts on selected micromycetes]. | inhibitory effects of two fungistatic preparations (a and b) and of propionic acid were tested in a complete feed mixture for broiler chickens (starter mixture). the water content of this mixture was 25.4%, environmental temperature was 24 degrees c and relative air humidity 90%. propionic acid, which has a high fungistatic effect, served as a standard. the composition of the preparation a was as follows: propionic acid, acetic acid, sorbic acid, citric acid and calcium propionate. the preparati ... | 1992 | 1297244 |
| toxigenic fungi in food. | forty-five fungal isolates from moldy supermarket foods were tested for toxicity to brine shrimp, and twenty-two of these isolates were subsequently tested for toxicity to chicken embryos. highly toxigenic fungi were cladosporium sphaerospermum from a bakery product, fusarium oxysporum from carrots, f. solani from cabbage, aspergillus niger and penicillium corylophilum from bread, p. cyclopium and p. herguei from corn meal, p. lanosum from onions,p. steckii from chocolate syrup, penicillium sp. ... | 1975 | 1147614 |
| [isolation, purification and identification of phytotoxic substances from penicillium sp., str. 659]. | | 1976 | 1012098 |
| a butyrylcholinesterase inhibitor produced by penicillium sp. no. c-81 and its identity with mycelianamide. | a screening aimed at obtaining a cholinesterase inhibitor of microbial origin was carried out using pseudomonas butyrylcholinesterase. a mycelium-extract of a fungus strain, belonging to the genus penicillium, was found to produce such an enzyme inhibitor. the inhibitor was purified and crystallized as colorless leaflets. from physical and chemical studies, the inhibitor was identified as being identical with an antibiotic, mycelianamide, though this compound was not known to have enzyme inhibit ... | 1976 | 956041 |
| fungal ornithine esterases: relationship to iron transport. | extracts of fusarium roseum (atcc 12822) contain an enzyme which hydrolyzes the ornithine ester bonds of fusarinine c, a cyclic trihydroxamic acid produced by this organism. the methyl ester of ndelta-dinitrophenyl-l-ornithine is also a substrate for the enzyme, and an assay was devised using this substrate. the enzyme exhibits a sharp maximum of activity at ph 7.5 and is extremely temperature sensitive. it is strongly inhibited by hgcl2 and p-chloromercuribenzoate, and it is competitively inhib ... | 1976 | 949472 |
| influence of cadmium on certain biological activities in a cadmium-tolerant fungi. | aspergillus carbonarius and a strain of penicillium are able to grow on harrold's agar media amended with different concentrations of cadmium chloride up to 2.5% (w/v). considerable quantities of cadmium were absorbed by both fungi. a. carbonarius absorbed more cadmium than the penicillium sp. did, under the same culturing conditions. in the presence of cadmium, the determined cellular contents of proteins, lipids, and carbohydrates were extraordinary high, whereas the activities of certain enzy ... | 1988 | 2484563 |
| [detection of cyclopiazonic acid and its producers in food]. | in the course of six months, 60 samples of foods were examined for their contents of cyclopiazonic acid. these samples were subjected to a basal mycological screening aimed at aspergillus flavus and penicillium sp. strains. cyclopiazonic acid contents in samples of hermelín cheese, peanuts, rice, peeled barley grains, folican salami, and packaged meat did not exceed the value of 0.5 mg.kg-1. when using a modification of the method of cyclopiazonic acid isolation described by dorner et al. (1983) ... | 1989 | 2508296 |
| yeast-suspension as soiling matter in disinfectant testing. | using the kelsey-sykes capacity-test, it was found that a sterile yeast suspension used to simulate 'dirty' conditions, gave an increased effect of chloramine t against the fungi candida albicans, aspergillus fumigatus, geotrichum candidum and penicillium sp. compared with the effect under 'clean' conditions. this effect was not found with the fungus rhodotorula rubra nor on the various bacteria tested. the enhanced effect was found with respect to both chloramine t and chloramine b, but not wit ... | 1989 | 2661973 |
| [using anti-sera and monoclonal antibodies against aspergillus fumigatus to study its cross-reactions with alternaria alteria and penicillium sp]. | using rabbit polyclonal and mouse monoclonal antibodies against aspergillus fumigatus, we analyzed their cross-reaction with alternaria alteria and penicillium sp. by enzyme immuno assay (eia) and radioimmunoprecipitation (rip). it was found that neither of these two categories of antibodies reacted with alternaria alteria while both reacted with penicillium sp.. when components from penicillium sp. precipitated by rabbit antisera were analyzed on 10% sds-polyacrylamide gel electrophoresis (sds- ... | 1989 | 2670140 |
| dermatomycosis in dogs. | during the routine examination of dogs for cutaneous lesions, 205 dogs were screened for fungi other than dermatophytes. twenty-two dogs (10.8%) revealed the presence of non-dermatophytic fungi suspicious for representing the etiologic agents of the skin lesions. the fungi isolated were alternaria sp. (2.9%), penicillium sp. (2.4%), aspergillus fumigatus (2.0%), mucor sp. (1.5%), cladosporium sp. (1.5%) and fusarium sp. (0.5%). no dermatophyte was isolated in association with these fungi. the in ... | 1989 | 2710156 |
| [presence of potentially pathogenic bacteria and fungi in the cooling-lubricating emulsion used in the aluminum sheet rolling process]. | microbiological tests of aluminium rolling water-oil emulsion reveal high level of contamination: relatively anaerobic bacteria 10(6)-10(8) cells/ml, fungi and yeasts 10(3)-10(4) cells/ml, and also anaerobic bacteria desulfovibrie sp. reducing sulfates to hydrogen sulfide. in emulsion samples there were present bacterial strains potentially dangerous to health, belonging to the family enterobacteriaceae, vibrionaceae, pseudomonadaceae, bacillaceae. the fungi and yeasts found in the emulsion were ... | 1989 | 2755339 |
| woodman's disease: hypersensitivity pneumonitis from cutting live trees. | a 28-year-old man developed multiple episodes of fever, cough, shortness of breath, and leukocytosis several hours after cutting live oak and maple trees. fungal cultures of wood chips from oak and maple trees were positive for penicillium (three species), paecilomyces sp., aspergillus niger, aspergillus sp., and rhizopus sp. gel-immunodiffusion studies demonstrated serum precipitins to extracts of oak chips, penicillium sp., and paecilomyces sp., and suggested that penicillium sp. and paecilomy ... | 1988 | 3123541 |
| methylenolactocin, a novel antitumor antibiotic from penicillium sp. | a novel antitumor antibiotic, methylenolactocin, was isolated from the culture filtrate of a new isolate of fungus identified as penicillium sp. the fermentation yield reached about 100 mg per liter of the broth. methylenolactocin has the molecular formula of c11h16o4 and possess an exomethylene lactone structure. its structure was determined to be 3-carboxy-2-methylene-4-nonanolide by spectroscopic data. it is active against some gram-positive bacteria and it prolongs the life span of mice inoc ... | 1988 | 3403369 |
| fungitoxic effects of nonprotein imino acids on growth of saprophytic fungi isolated from the leaf surface of calliandra haematocephala. | four saprophytic and pathogenic fungi were isolated from the leaf surface of calliandra haematocephala, a tropical legume known to contain large amounts of rare nonprotein imino acids in its leaves and seeds. the fungi aspergillus niger, aspergillus sp., curvularia sp., and penicillium sp. were cultured in the laboratory and tested for susceptibility to leaf extracts of the host plant and to proline, pipecolic acid, cis-5-hydroxypipecolic acid, and 2,4-trans-4,5-cis-4,5-dihydroxypipecolic acid. ... | 1986 | 3707119 |
| [mycoflora of hay and straw]. | studies were carried out on hay and straw to establish the composition of mycoflora in them. they were sampled both at the time of harvesting and after storing for four to five months. it was found that the hay and straw were most often inseminated with spores of the fungus species alternaria tenuis, aspergillus fumigatus, mucor hiemalis, penicillium sp., and more rarely with spores of fusarium, chaetomium, scopulariopsis, cladosporium, trichoderma, and stachybotrys alternans. it was demonstrate ... | 1986 | 3739224 |
| mycotic endophthalmitis caused by penicillium sp. after parenteral drug abuse. | a 30-year-old man developed endophthalmitis three weeks after an intravenous injection of hydromorphone hydrochloride. penicillium species was recovered from a vitreous aspirate. treatment with amphotericin b and flucytosine resulted in documented sterilization of the vitreous. at a six-month follow-up examination, the visual acuity of the involved eye was still limited to light perception. | 1985 | 4037026 |
| activity of polygalacturonase and pectinesterase of penicillium sp 7/4b after ethylenoimine and uv treatment. | | 1974 | 4425355 |
| isolation and identification of a toxic hydrophilic metabolite from the culture broth of penicillium sp. 171. | | 1973 | 4522053 |
| a new fungal lactone, ll-p880 beta, and a new pyrone, ll-p880 gamma, from a penicillium sp. | | 1973 | 4780824 |
| structure of a new fungal lactone, ll-p880 , from an unidentified penicillium sp. | | 1972 | 5037459 |
| biochemical decomposition of the herbicide n-(3,4-dichlorophenyl)-2-methylpentanamide and related compounds. | organisms capable of decomposing n-(3,4-dichlorophenyl)-2-methylpentanamide (karsil) were isolated, identified, and tested for their ability to hydrolyze this herbicide. primary products of karsil decomposition by cells and cell-free extracts of a penicillium sp. were identified as 2-methyl-valeric acid and 3,4-dichloroaniline. the karsil acylamidase (ec 3.5.1.a aryl acylamine amidohydrolase) was an induced enzyme. it was partially purified and tested for its ability to hydrolyze 25 related comp ... | 1969 | 5373674 |
| the metabolism of aromatic acids by micro-organisms. metabolic pathways in the fungi. | 1. the metabolic pathways of aromatic-ring fission were examined in a range of fungal genera that utilize several compounds related to lignin. 2. most of the genera, after growth on p-hydroxybenzoate, protocatechuate or compounds that are degraded to the latter (e.g. caffeate, ferulate or vanillate), rapidly oxidized these compounds, but not catechol. 3. such genera possessed a protocatechuate 3,4-oxygenase and accumulated beta-carboxymuconate as the product of protocatechuate oxidation. this en ... | 1968 | 5691754 |
| [production and characteristics of penicillium sp. no. 19 toxin]. | | 1966 | 6004937 |
| studies on the induction of aryl hydrocarbon(benzo[a]pyrene) hydroxylase in neurospora crassa, and its suppression by sodium selenite. | six fungal species were grown in the presence of benzo[a]pyrene (bp); four showed benzo[a]pyrene hydroxylase (aryl hydrocarbon hydroxylase, ahh) activity. penicillium sp. and neurospora crassa metabolized bp to a limited extent. n. crassa ahh activity was induced by bp, the major product of metabolism being 3-hydroxy-bp. both induction of ahh activity and metabolism of bp were suppressed by sodium selenite in the growth medium. two polypeptides, unique to bp-grown cells, were revealed by two-dim ... | 1984 | 6241764 |
| [fungal flora in a hospital environment]. | the airborne fungal flora was studied in different departments of a hospital by using a slit sampler (casella, london) where the measured volume of air is impacted to the surface of culture medium contained in petri dishes. colonies were counted after 3 days incubation at 25 degrees c and 37 degrees c. many species of hyphomycetes were identified. the main fungi isolated were cladosporium sp (especially c. cladosporioides), penicillium sp., alternaria alternata, aspergillus sp. (a. flavus, a. ni ... | 1983 | 6312583 |
| [fungal flora in a hospital milieu]. | the airborne fungal flora was studied in different departments of an hospital by using a slit sampler (casella, london) where the measured volume of air is impacted to the surface of culture medium contained in petri dishes. colonies were counted after 3 days incubation at 25 degrees c and 37 degrees c. many species of hyphomycetes were identified. the main fungi isolated were cladosporium sp (especially c. cladosporioides), penicillium sp., alternaria alternata, aspergillus sp. (a. flavus, a. n ... | 1983 | 6343973 |
| evaluation of an indirect hemagglutination inhibition technique for identifying antibody in animals experimentally and naturally exposed to fungi. | rabbits were exposed to aerosols containing spores of aspergillus fumigatus, aspergillus flavus, aspergillus niger, or of a penicillium sp. sera from these rabbits were tested by indirect hemagglutination (iha) and by iha inhibition. the serologic reactions with the rabbit sera were compared to reactions with sera from cattle naturally exposed to airborne microorganisms. by three months of age, most cattle had positive iha reactions to a. fumigatus and penicillium antigens. the iha inhibition te ... | 1984 | 6493314 |
| a rapid and sensitive paper electrophoresis assay for the detection of microbial siderophores elicited in solid-plating culture. | a rapid and sensitive assay for the detection of microbial siderophores (iron-binding compounds) is described. nine representative fungal and bacterial cultures including ustilago sphaerogena, penicillium sp., fusarium roseum, rhodotorula pilimanae, bacillus subtilis w 23, bacillus subtilis w 168, bacillus megaterium, azotobacter vinelandii op, and escherichia coli b, were nutritionally stressed for iron by sequential transfers on iron-deficient solid-plating media. in response to fe-stress cond ... | 1983 | 6614486 |
| oxidation of acetylpolyamines by extracellular polyamine oxidase produced by penicillium sp. no. po-1. | the oxidation of acetylpolyamines by an extracellular polyamine oxidase of penicillium sp. no. po-1 was investigated. the optimal ph value for oxidation of acetylpolyamines was 6.0. the purified enzyme oxidized spermidine, spermine, n1-acetylspermidine, n8-acetylspermidine, n1,8-diacetylspermidine, n1-acetylspermine and n1,12-diacetylspermine. the relative velocities for oxidation of acetylpolyamines were lower than those of spermidine and spermine. the km values for oxidation of acetylpolyamine ... | 1983 | 6830819 |
| phosphate-solubilizing potentiality of the microorganisms capable of utilizing aluminium phosphate as a sole phosphate source. | eight bacteria, each of the genus bacillus, two actinomycetes, each of the genus streptomyces, and six fungi, one each of the genus penicillium and chaetomium and four of the genus aspergillus, were isolated on alpo4-sucrose agar from a typical indian lateritic soil (typic ochragualf). all of them were capable of solubilizing ca3(po4)2 to a higher degree than alpo4. bacillus subtilis (b-7655), lab4, bacillus sp., lab5, penicillium sp., laf2, and aspergillus spp., laf3 and laf4, were solubilizing ... | 1983 | 6845902 |
| atpenins, new antifungal antibiotics produced by penicillium sp. production, isolation, physico-chemical and biological properties. | penicillium sp. fo-125, a soil isolate, was found to produce a new antifungal antibiotic complex named atpenin. three components a4, a5 and b were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and hplc. the molecular formula of atpenins a4, a5 and b were determined to be c15h22no5cl, c15h21no5cl2 and c15h23no5, respectively, on the basis of high resolution electron impact mass spectrometry and elemental analysis. they are act ... | 1988 | 3209470 |
| metabolism of pah by fungi and correlation with extracellular enzymatic activities. | the activity to metabolize the polycyclic aromatic hydrocarbons (pah) phenanthrene, anthracene, pyrene, fluorene and fluoranthene by trametes versicolor, pleurotus ostreatus (white rot fungi), laetiporus sulphureus, daedaela quercina, flamulina velutipes (brown rot fungi), marasmiellus sp. (litter decaying fungus) and penicillium sp. m 1 (isolated from a pah contaminated soil sample) were compared. screening methods for the presence of exoenzymes (peroxidases, polyphenoloxidases, "radical genera ... | 1993 | 8229670 |
| [studies on using choline salt of n-glucosylpolyfungine as an antifungal preparation for cell culture]. | fungistatic and fungicidal activity as well as the toxicity of the polyfungine derivative of choline n-glucosylpolyfungine salt for chicken embryo fibroblasts were studied. this preparation was found to inhibit the growth of candida albicans, aspergillus niger and penicillium sp. at 25-100 micrograms/ml concentrations of the medium. the highest sensitivity to polyfungine was shown by c. albicans strain, and the lowest by aspergillus niger strain. the preparation studied did not lose its activity ... | 1987 | 3320997 |
| [the effect of lipase from penicillium sp. on the membrane fraction of the levorin-producing streptomyces levoris]. | the effect of a lipase preparation from penicillium sp. on the membranes of the levorin producer streptomyces levoris was being studied. the enzyme preparation was found preferably to hydrolyse neutral lipids in the str. levoris membranes, which makes it possible to use the lipase from penicillium sp. for studying neutral lipids in microbial membranes. | 1988 | 3387382 |
| studies on synergisidin. | penicillium sp. no. y-11930 was isolated from soil sample collected at shimouma, setagaya, tokyo in september 1978. synergisidin produced by the strain was obtained with high yield in starch-corn steep liquor medium, extracted with ethyl acetate at ph 5.0 and crystallized from ethyl acetate after decolorization with active charcoal. the antibacterial activities of synergisidin against gram-positive and gram-negative bacteria and mycobacterium were almost nothing but synergisidin showed weak acti ... | 1981 | 7241806 |
| [lipolytic complex of penicillium sp]. | by gel filtration on sephadex g-75 it has been demonstrated that the lipolytic complex of penicillium sp. contains two active components--a high molecular weight (lipase-1) and low molecular weight component (lipase-2). both components have been isolated by sephadex gel-filtration and deae-cellulose chromatography. it has been shown by discelectrophoresis and isoelectric focusing that lipase-2 is a highly purified protein with the molecular weight of 30,000 (gel-filtration) or 29,000 (electropho ... | 1981 | 7323025 |
| orbital cellulitis, sinusitis, and pneumonitis caused by penicillium sp in a cat. | | 1980 | 7358563 |
| isolation and in vitro antibacterial screening of a tricarboxylic acid anhydride from penicillium sp. | | 1995 | 7501697 |
| benzomalvins, new substance p inhibitors from a penicillium sp. | in the course of screening microbial broths for neurokinin receptor antagonists, a series of new benzodiazepines, benzomalvins a (1), b (2) and c (3), has been isolated from the culture broth of a fungus identified as a penicillium sp. benzomalvin a (1) showed inhibitory activity against substance p with ki values of 12, 42 and 43 microm at the guinea pig, rat and human neurokinin nk1 receptors, respectively. benzomalvins b (2) and c (3) were only weakly active. the structures of these compounds ... | 1994 | 7518818 |
| disseminated opportunistic fungal disease in dogs: 10 cases (1982-1990). | medical records of 10 dogs in which fungal infection was diagnosed between 1982 and 1990 were reviewed. in each dog, infection was determined to be caused by a single species of fungus, either aspergillus terreus, penicillium sp, paecilomyces sp, chrysosporium sp, or pseudallescheria boydii. nine dogs were german shepherd dogs; 1 was a german shepherd dog cross, and 9 were females. the most common clinical signs were signs of neck or back pain (9 dogs), weight loss (7 dogs), anorexia (6 dogs), p ... | 1995 | 7601696 |
| [results of mycologic examinations of sputum in patients with pulmonary diseases during a 10-year period (1984-1993)]. | the study of present results of mycologic examinations of samples of sputums taken during the period from 1984 to 1993 from patients with pulmonary diseases. the examined group was constituted of 2,452 subjects, out of which 2/3 were male and 1/3 were female patients. the risk age category was discovered to be that over 61 years of age (32%). 70% of mycologic cultivations were positive. 1.640 etiologic agents were isolated from the positive samples. the most frequently isolated yeast species wer ... | 1995 | 7633933 |
| arisugacin, a novel and selective inhibitor of acetylcholinesterase from penicillium sp. fo-4259. | | 1995 | 7649881 |
| study of the alkaloid composition of the food-infecting penicilles. | over 30 strains of various penicillium sp. isolated from food have been screened for the ability to synthesize mycotoxins of an alkaloid nature. the most productive were p. expansum, p. raciborskii, p. puberulum, p. commune, p. viridicatum, p. chrysogenum, p. palitans, p. purpurescens and p. cyclopium. the separate components of the alkaloid mixtures have been isolated and identified. the range of metabolites synthesized by different strains of the same species was considerably expanded. new pro ... | 1995 | 7664943 |
| isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur. | dehydroaltenusin, cyclooctasulfur, atrovenetinone, and altenusin were isolated from the culture broths of penicillium verruculosum iam-13756, streptomyces verticillus subsp. tskushiensis atcc-21633, penicillium sp. spc-16375, and penicillium sp. spc-16524, respectively, as new myosin light chain kinase (mlck) inhibitors. these compounds inhibited the calmodulin-dependent activity of mlck with ic50 values of 0.69, 0.86, 3.7, and 350 microm, respectively. among them, dehydroaltenusin was the best ... | 1995 | 7670197 |
| massive fungal contamination in animal care facilities traced to bedding supply. | during the course of immunologic studies involving the gastrointestinal colonization of mice with candida albicans, it became apparent that the animals were being exposed to large numbers of aspergillus fumigatus spores which interfered with the c. albicans colonization. to determine the source of the a. fumigatus exposure and the extent of fungal contamination of the medical school vivarium and four satellite facilities, fungal analyses of feed, bedding, and air were undertaken. initial samples ... | 1995 | 7793950 |
| fudecalone, a new anticoccidial agent produced by penicillium sp. fo-2030. | penicillium sp. fo-2030, a soil isolate, was found to produce a new anticoccidial compound. the active compound, designated fudecalone, was isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and preparative hplc. the structure of fudecalone was elucidated to be 3,3a,6,6a,7,8,9,10-octahydro-1-hydroxy-4,7,7-trimethyl-1h-naphtho[1,8a- c]furan-6-one mainly by spectroscopic studies including various nmr measurements. the anticoccidial ... | 1995 | 7868390 |
| arohynapene d, a new anticoccidial agent produced by penicillium sp. fo-2295. | | 1995 | 7868394 |
| interactions of enzymes and fungi with crosslinked polyurethanes prepared for biomedical applications. | shelf life and long-term environmental stability of polyurethanes intended for percutaneous applications and various biomedical applications are largely depend on their resistance to fungal attack and growth. two classes of aliphatic crosslinked polyurethanes based on hexamethylene diisocyanate (hdi) and bicyclo-hexyl-methane diisocyanate (sm di) were subjected to cell-free enzymatic degradation using hydrolytic and oxidative enzymes and to fungal attack and fungal growth using aspergillus niger ... | 1994 | 7877571 |
| prevalence of fungal corneal ulcers in northern india. | fungal corneal ulcer is common in india due to the tropical climate and a large agrarian population that is at risk. various factors such as trauma, the injudicious use of topical antibiotics and corticosteroids are involved. many of the age and sex-related risk factors also play a minor role. this 6-year study from northern india revealed that fungi were detected in 61 (8.4%) out of 730 patients investigated. direct microscopy was positive in 51 (7%) and culture in 53 (7.3%) patients. aspergill ... | 1994 | 7927819 |
| antifungal activity of allylamine derivatives. | the antifungal activity of the two allylamine derivatives, naftifine and terbinafine was investigated against 25 clinical isolates of filamentous fungi by agar dilution method. the isolates included aspergillus sp. (10), penicillium sp. (3), cladosporium sp. (3), rhizopus sp. (3), paecilomyces sp. (2), syncephalastrum sp. (1), pyrenochaeta romeroi (1), piedraia hortae (1) and mortierella sp. (1). terbinafine was found to be more active than naftifine, inhibiting 50 per cent (mic 50) and 90 per c ... | 1994 | 8005641 |
| effects of sodium chloride and relative humidity on growth and sporulation of moulds isolated from cured fish. | a total of 14 moulds were isolated from 84 samples of cured fish obtained from several processing centres and retail shops in lagos, ogun and oyo states, nigeria. aspergillus niger, a. flavus and a. chevalieri were the most prevalent. with the exception of basipetospora sp., slight inhibition of mycelial growth and/or sporulation was recorded when isolates were cultured in basal medium containing 5% sodium chloride. the extent of inhibition increased with increasing salt concentrations, and at 2 ... | 1994 | 8028651 |
| arohynapenes a and b, new anticoccidial agents produced by penicillium sp. taxonomy, fermentation, and structure elucidation. | penicillium sp. fo-2295, a water isolate, was found to produce a series of new anticoccidial compounds. two active compounds, designated arohynapenes a and b, were isolated from the fermentation broth of the producing strain by solvent extration and preparative hplc. arohynapene a was deduced to be (2e,4e)-5-(5-hydroxy-2,6,8-trimethyl-5,6,7,8-tetrahydronaphtale ne)-2,4- pentadienoic acid, and arohynapene b was (2e,4e)-5-(2-hydroxymethyl-6,8-dimethyl-5,6,7,8-tetrahydronapht alene)-2,4- pentadieno ... | 1994 | 8119861 |
| [indoor air studies of mould fungus contamination of homes of selected patients with bronchial asthma (with special regard to evaluation problems)]. | investigations of indoor air of the homes of seven patients with asthma bronchiale who showed up with positive reactions following intracutaneous application of fungal allergens revealed that their places of residence were contaminated by fungal and bacterial spores. the number of colony forming units of mesophilic fungal spores of the indoor air ranged from 100 to 1000 cfu/m3 and this was much higher than the mould flora of the outdoor air determined simultaneously. the major fungi species foun ... | 1996 | 9376049 |
| [mycosis of the foot in people over 40]. | some aspects of the ecology of the human foot in the stage of senescence have been studied. systematically 200 hospitalized patients, chosen at random, between the ages of 40 and 96 years were examined. the following was observed: 1.) 133 patients (66,5%) presented lesions suspected as dermatomycoses. 2.) 67 patients (33,5%) were free from clinical lesions. 42 (31,5%) positive direct examinations were obtained from the first group and 8 (11,8%) from the second one. in culture were isolated diffe ... | 1981 | 7022054 |
| a new inhibitor of synovial phospholipase a2 from fermentations of penicillium sp. 62-92. | penidiamide, a new tripetide containing dehydrotryptamine, glycine and anthranilic acid linked together by two amide bonds, and oxindole were isolated from submerged cultures of penicillium sp. 62-92. both compounds preferentially inhibited human synovial phospholipase a2, penidiamide with an ic50 of 30 microm and oxindole of 380 microm. with the exception of u 937 cells (leukemia, human), no cytotoxic activities were detected against hl-60- (leukemia, human), hela s3- (epitheloid carcinoma, hum ... | 1998 | 9528122 |
| [pectolytic enzymes formed by penicillium and fusarium micromycetes]. | the ability of the two cultures penicillium sp. and fusarium sp. to synthesize extracellular pectolytic enzymes was investigated. the cultivation conditions providing a high level of the biosynthesis of these enzymes were identified. the methods of isolating the enzymes by means of organic solvents were developed. the pectinase from penicillium sp. showed a higher thermostability whereas that from fusarium sp. displayed a greater acid resistance. using glutaraldehyde and titanium salts, active i ... | 1982 | 7082428 |
| specific amplification of aspergillus fumigatus dna by polymerase chain reaction. | we have developed a specific and sensitive method to detect the human pathogen aspergillus fumigatus by polymerase chain reaction (pcr) with an objective of detecting the organism in peripheral blood and urine which can be obtained by non-invasive procedures. a pair of oligonucleotide primers for pcr were designed based on the published partial protein sequences of an 18 kd ige-binding protein of a. fumigatus asp f1 and the ribotoxins mitogillin and restrictocin of a. restrictus, and alpha-sarci ... | 1993 | 8321251 |
| peritonitis due to penicillium sp in a patient receiving continuous ambulatory peritoneal dialysis. | infectious peritonitis is a common complication of continuous ambulatory peritoneal dialysis (capd). only one case of capd-related peritonitis due to penicillium sp has previously been reported. we present a second case in which fungal colonies were observed on the inner surface of the capd catheter. the infection was successfully treated with catheter removal and intravenous amphotericin b. | 1996 | 8545701 |
| phenopyrrozin, a new radical scavenger produced by penicillium sp. fo-2047. | a new radical scavenger, named phenopyrrozin, was isolated from the culture broth of penicillium sp. fo-2047. phenopyrrozin was purified from whole broth solvent extraction, silica gel chromatography, and hplc. the structure of phenopyrrozin was elucidated as 5,6,7,7a-tetrahydro-2-hydroxy-1-phenyl-3h-pyrrolizin-3-one. the ic50 of phenopyrrozin against lipid peroxidation induced by cr2k2o7 was 73 micrograms/ml. phenopyrrozin also reduced chromosomal aberrations induced by paraquat. | 1995 | 8557596 |
| production of reactive oxygen metabolites by opsonized fungi and bacteria isolated from indoor air, and their interactions with soluble stimuli, fmlp or pma. | changes in the levels of free intracellular calcium ([ca2+]i) and the production of reactive oxygen metabolites (rom) induced by opsonized indoor air fungi and bacteria in human polymorphonuclear leukocytes (pmnl) were measured. moreover, modification of a chemotactic peptide (fmlp)-and a tumor promoter (pma)-induced production of rom by opsonized fungi and bacteria were studied. the cells were exposed to graded doses of opsonized candida sp., aspergillus sp., cladosporium sp., stachybotrys sp., ... | 1995 | 8608771 |
| new isochromophilones vii and viii produced by penicillium sp. fo-4164. | new isochromophilones vii and viii were isolated from the culture broth of penicillium sp. fo-4164. the structures were elucidated as 6h-2-benzopyran-6,8(7h)-dione, 5-chloro-3-(3',5'-dimethyl-1',3'-heptadienyl)-1,7,8a-trihydro-7, 8a-dihydroxy-7-methyl-7-acetate for isochromophilone vii and 6h-2-benzopyran-6-one,5-chloro-3-(3',5'-dimethyl-1', 3'-heptadienyl)-1,7,8,8a-tetrahydro-7,8-dihydroxy-7-methyl-8-acetate for isochromophilone viii. isochromophilones vii and viii inhibited diacylglycerol acyl ... | 1996 | 8626234 |
| microbial models of soil metabolism: biotransformations of danofloxacin. | danofloxacin is a new synthetic fluoroquinolone antibacterial agent under development for exclusive use in veterinary medicine. such use could lead to deposition of low levels of danofloxacin residues in the environment in manure from treated livestock. this study was conducted to evaluate the potential for indigenous soil microorganisms to metabolize danofloxacin. cultures of 72 soil microorganisms representing a diverse panel of bacteria, fungi and yeast were incubated with danofloxacin mesyla ... | 1997 | 9451835 |
| structural determination of stevastelins, novel depsipeptides from penicillium sp. | structures of novel immunosuppressants, stevastelin a, b and b3(1) were determined by their spectroscopic and chemical studies. three stevastelins were shown to be cyclic depsipeptides composed of a fatty acid and three amino acid moieties. the sequence of these moieties was determined to be as 3,5-dihydroxy-2,4-dimethylstearylvalylthreonyl (or o-sulfonylthreonyl in stevastelin a)-o-acetylserine. cyclic structures were shown to be formed by ester linkages between the carboxylic group of the o-ac ... | 1996 | 8698640 |
| andrastins a-c, new protein farnesyltransferase inhibitors produced by penicillium sp. fo-3929. ii. structure elucidation and biosynthesis. | the structures of new protein farnesyltransferase inhibitors, andrastins a-c, were elucidated. the cyclopentane ring of andrastins exhibited keto-enol tautomerism, which made the structure hard to elucidate. therefore, the structure of andrastin a was elucidated by inadequate and 13c-13c couplings using 13c-labeled andrastin a. the absolute configuration of the p-bromobenzoyl derivative of andrastin a was elucidated by x-ray crystallographic analysis and its skeleton was shown to be ent-5 alpha, ... | 1996 | 8682717 |
| andrastins a-c, new protein farnesyltransferase inhibitors produced by penicillium sp. fo-3929. i. producing strain, fermentation, isolation, and biological activities. | new protein farnesyltransferase inhibitors, andrastins a-c, have been discovered in the cultured broth of penicillium sp. fo-3929. andrastins extracted from broth supernatant were purified by silica gel chromatography, ods chromatography and hplc. the ic50 of andrastins a, b, and c against protein farnesyltransferase were 24.9, 47.1, and 13.3 microm, respectively. | 1996 | 8682716 |
| study of the micro-organisms associated with the fermented bread (khamir) produced from sorghum in gizan region, saudi arabia. | traditional bread (khamir) was made from sorghum flour of two local varieties, bayadh and hamra. the bread was prepared by mixing the sorghum flour with water and spices (onion, garlic, lemon juice and fenugreek) in a 1:0.8 (w/w) ratio and fermented for 24 h at 30 degrees c. two other fermentations were carried out using an inoculum from the previous fermentation. the micro-organisms were isolated from different plates and identified using different characterization systems. both total bacterial ... | 1999 | 10063620 |
| molds on house walls and the effect of their chloroform-extractable metabolites on the respiratory cilia movement of one-day-old chicks in vitro. | the ciliostatic activity of the chloroform-extractable endo- and exometabolites of 5 strains of filamentous fungi--alternaria sp., aspergillus glaucus group, aspergillus versicolor, cladosporium sphoerospermum, penicillium sp. and ulocladium sp.--isolated from molded walls of a dwelling--on tracheal cilia from 1-d-old chicks in vitro was evaluated. endometabolites of alternaria sp. and a. versicolor and exometabolites of ulocladium sp. were the most active, these extracts stopped the ciliary mov ... | 1998 | 10069012 |
| arisugacins a and b, novel and selective acetylcholinesterase inhibitors from penicillium sp. fo-4259. ii. structure elucidation. | the structures of new acetylcholinesterase inhibitors, arisugacins a and b, were elucidated by nmr study. arisugacins have a (4ar,6ar,12as,12bs)-4a,6,6a,12,12a, 12b-hexahydro-4a,12a-dihydroxy-4,4,6a,12b-tetramethyl-4h,11h -naphtho[2,1-b] pyrano[3,4-e]pyran-1,11(5h)-dione moiety in common and 3,4-dimethoxyphenyl or 4-methoxyphenyl residues are attached to c-9 of the moiety. | 1996 | 8823505 |
| purification and characterization of a glycerol oxidase from penicillium sp. ts-622. | a novel extracellular glycerol oxidase was purified 39-fold from wheat bran culture of a soil-isolated penicillium strain ts-622 with an overall yield of 3%. the addition of triton x-100 into the extraction buffer improved the extraction yield by 90 times, indicating that the enzyme is bound to the cell surface. the molecular weight of this enzyme was 400,000 as determined by size-exclusion high-performance liquid chromatography. the optimum ph was from 6 to 7 and the optimum temperature was 45 ... | 1996 | 8882006 |
| stevastelin a3, d3 and e3, novel congeners from a high producing mutant of penicillium sp. | | 1996 | 8968400 |
| absolute structural determination of stevastelin b. | stevastelin b, obtained from a culture of a penicillium sp. nk374186, is a novel depsipeptide containing three amino acids and 3,5-dihydroxy-2,4-dimethylstearic acid. the stereochemistry of the three amino acids was determined by hplc analysis, and the relative configuration of the 3,5-dihydroxy-2,4-dimethylstearic acid was elucidated by chemical conversion and nmr analysis. the absolute stereochemistry of stevastelin b was determined by synthetic methods. | 1996 | 8698641 |
| purification and characterization of a penicillium sp. lipase which discriminates against diglycerides. | a lipase was isolated from penicillium sp. strain uzlm-4 and characterized. this lipase has a molecular weight of 27,344 (determined by mass spectrometry) and hydrolyzes triglycerides in preference to mono- and diglyceride substrates. among various triglyceride substrates, tributyrin is hydrolyzed about four times faster than any other tested. the lipase has a preference for hydrolysis at the 1,3 positions of the lipids and shows a weak stereoselectivity for the s enantiomer. unlike most other l ... | 1996 | 8743049 |
| antimicrobial activity of food-related penicillium sp. against pathogenic bacteria in laboratory media and a cheese model system. | food-related penicillium species (n = 34) and geotrichum candidum (n = 11) grown on czapek dox and brie agar were tested for their ability to suppress growth of pathogenic bacteria. ten out of 13 p. camemberti showed antagonistic activity while the other species did not interact significantly with the bacterial growth. the order of inhibition was: gram-negative bacteria and bacillus cereus > listeria monocytogenes, lactococcus sp. > micrococcus sp. whereas lactobacillus sp., staphylococcus aureu ... | 1997 | 9246777 |
| a new method of synthesizing biopolymeric affinity ligands. | (1) a new concept for producing soluble polymeric affinity ligands is proposed and exemplified. by solid-phase synthesis, an insoluble hydrophilic polymer is converted into an affinity gel. the gel is hydrolytically degraded to water-soluble affinity polymeric ligands which are recovered and purified. (2) a water-soluble biopolymeric metal-affinity carrier based on an iminodiacetic acid (ida) derivative of dextran has been synthesized through the modification of sephadex g-200 by ida, followed b ... | 1997 | 9261997 |
| arisugacins a and b, novel and selective acetylcholinesterase inhibitors from penicillium sp. fo-4259. i. screening, taxonomy, fermentation, isolation and biological activity. | an in vitro screening method for selective acetylcholinesterase (ache) inhibitors was established. inhibitory activity of ache and butyrylcholinesterase (buche) was measured and the culture broths of microorganisms that showed selective inhibition against ache were characterized. by using this method, a strain producing the novel and selective inhibitors of ache, arisugacins a and b, was picked out among over seven thousand microorganisms tested. arisugacins were obtained as white powders from t ... | 1996 | 8823504 |