[effects of liensinine on haemodynamics in rats and the physiologic properties of isolated rabbit atria].liensinine(lien), an alkaloid extracted from the green seed embryo of nelumbo nucifera gaertn, has been shown to have anti-arrhythmic action, its mechanism may be related to blockade of ca2+, na+ influx. lien 3 mg/kg i.v. may temporarily inhibit all parameters of haemodynamics in anesthetized or pithed rats. the inhibitory effects on lvp, +dp/dtmax and sap in anesthetized rats are slightly stronger than those of quinidine (qui) 3 mg/kg. lien 1-30 mg/kg dose-dependently produced these actions. li ...19921299135
[effects of neferine on heart electromechanical activity in anaesthetized cats].neferine, an alkaloid extracted from the green seed embryo of nelumbo nucifera gaertn, has been shown to have anti-arrhythmic action. neferine 1-10 mg/kg iv dose-dependently decreased the monophasic action potential amplitude (mapa), prolonged the monophasic action potential duration (mapd). it also decreased lvp, dp/dt, prolonged scl, and reduced arterial blood pressure in a dose-dependent manner. these effects were similar to those of quinidine, and different from tetrandrine. the latter had a ...19902275392
[effects of neferine on transmembrane potentials of guinea pig myocardium].neferine, an alkaloid first isolated from the seed embryo of nelumbo nucifera gaertn in china, possesses an anti-arrhythmic action. the effects on the action potential duration (apd) and the maximal upstroke velocity (vmax) in different driving rates, the slow response action potentials of k+-depolarized ventricular myocardium and the ouabain-induced oscillatory potentials were studied in guinea pig papillary muscles. neferine 10 and 50 mumols/l markedly suppressed the transmembrane potentials v ...19892618727
[effects of neferine on transmembrane potential in rabbit sinoatrial nodes and clusters of cultured myocardial cells from neonatal rats].neferine (nef), a bis-benzylisoquinoline alkaloid first isolated from the seed embryo of nelumbo nucifera g in china, possesses an anti-arrhythmic action. the effects of nef on the transmembrane potential were studied in rabbit sinoatrial nodes and the clusters of cultured cardiac myocytes from neonatal rats. nef 30 mumol/l suppressed the amplitude of action potential (apa) from 57 +/- 5 to 42 +/- 4 mv, and the maximal upstroke velocity (vmax) from 1.7 +/- 0.3 to 0.9 +/- 0.4 v/s (n = 5, p less t ...19892624117
[effects of linesinine on slow action potentials in myocardium and slow inward current in canine cardiac purkinje fibers].standard microelectrode and two-microelectrodes voltage clamp techniques were used to study the effects of linesinine (lien), an alkaloid extracted from the green seed embryo of nelumbo nucifera gaertn, on slow action potentials (ap) and slow inward current (isi). lien 10-100 mumol/l was shown to concentration-dependently decrease the action potential amplitude (apa), the maximal velocity of phase 0 depolarization (vmax) and prolong the sinus cycle length (scl) of slow ap in isolated sinoatrial ...19937516605
retroviral reverse transcriptase inhibitory activity in thai herbs and spices: screening with moloney murine leukemia viral enzyme.fifty-seven thai herbs and spices were examined for their retroviral reverse transcriptase inhibitory activity. all herbs and spices were extracted with hot-water and methanol. reverse transcriptase inhibitory activity of the extracts was determined by using moloney murine leukemia virus reverse transcriptase (m-mulv-rt) reacted with 3h-dttp and radioactivity measured with a scintillation counter. eighty-one per cent (46/57) of hot-water extracts and 54% (31/57) of methanol extracts showed inhib ...19937524165
traditional chinese medicine in treatment of the search of new products for treatment of hyperlipidaemia with a low frequency of side effects a decoction of crataegus cuneata, nelumbo nucifera and gynostemma pentaphylla has been tested. a reduction of triglyceride and cholesterol was seen.19957650951
antipyretic activity of nelumbo nucifera rhizome extract.antipyretic activity of methanolic extract of rhizome of n. nucifera was studied on normal body temperature and yeast induced pyrexia in rats. yeast suspension (10 ml/kg, s.c.) increased rectal temperature after 19 hr of administration. the extract, in doses of 200, 300 or 400 mg/kg (po) produced significant dose dependent lowering of normal body temperature and yeast provoked elevation of body temperature in rats. the effect produced was comparable with the standard antipyretic drug, paracetamo ...19968781041
studies on psychopharmacological effects of nelumbo nucifera gaertn. rhizome extract.methanolic extract of rhizomes of nelumbo nucifera (nnre) was investigated for different psychopharmacological actions in rats and mice. the extract was found to cause reduction in spontaneous activity, decrease in exploratory behavioural pattern by the head dip and y-maze test, reduction in muscle relaxant activity by rotarod, 30 degrees inclined screen and traction test and potentiated the pentobarbitone induced sleeping time in mice significantly.19968953419
studies on the anti-inflammatory activity of rhizomes of nelumbo nucifera.the anti-inflammatory activity of the methanol extract of nelumbo nucifera rhizome as well as of betulinic acid, a steroidal triterpenoid isolated from it, were evaluated on carrageenin and serotonin induced rat paw edema. methanol extract at doses of 200 and 400 mg/kg and betulinic acid at doses of 50 mg/kg and 100 mg/kg p.o., showed significant anti-inflammatory activity in both the models of inflammation in rats. the effects produced were comparable to that of phenylbutazone and dexamethasone ...19979270384
effect of nelumbo nucifera rhizome extract on blood sugar level in rats.oral administration of the ethanolic extract of rhizomes of nelumbo nucifera markedly reduced the blood sugar level of normal, glucose-fed hyperglycemic and streptozotocin-induced diabetic rats, when compared with control animals. the extract improved glucose tolerance and potentiated the action of exogenously injected insulin in normal rats. when compared with tolbutamide, the extract exhibited activity of 73 and 67% of that of tolbutamide in normal and diabetic rats, respectively.19979421256
effect of nelumbo nucifera rhizome extract on the gastrointestinal tract of rat.extract of nelumbo nucifera rhizome (rnn) was used as anti-diarrheal agent to combat the diarrhea in experimental rats. the rnn extract in graded doses (100, 200, 400 and 600 mg/kg body wt.) reduced not only the frequency of defecation, wetness of fecal dropping and pge2 induced enteropooling but also the propulsive movements of charcoal meal significantly.19989776868
evaluation of antipyretic potential of nelumbo nucifera stalk extract.the ethanol extract of stalks of nelumbo nucifera (nnse) was evaluated for its antipyretic potential on normal body temperature and yeast induced pyrexia in rats. nnse showed significant activity in both the models at oral doses of 200 and 400 mg/kg. nnse at a dose of 200 mg/kg was found to produce significant lowering of normal body temperature up to 3 h and at 400 mg/kg it caused significant lowering of body temperature up to 6 h after its administration. in the model of yeast provoked elevati ...200010861971
[effects of neferine on platelet aggregation in rabbits].neferine (nef), a hypotensive agent with antiarrythmic action, is a dibenzyl isoquinoline alkaloid isolated from a chinese medicinal herb (nelumbo nucifera gaertn). its effects on platelet aggregation and txa2/pgi2 and camp/cgmp balance were studied with methods of turbidimetry and ria. nef was shown to significantly inhibit rabbit platelet aggregation induced by adp, collagen, arachidonic acid (aa) and platelet-activating factor (paf) with ic50 of 16, 22, 193 and 103 mumol.l-1, respectively. ne ...199711243209
net primary productivity of some aquatic macrophytes in sewage-sullage mixture.sewage-sullage mixture from raipur city is spread over a vast area surrounding the city. this mixture has a ph always above neutrality with high turbidity. transparency was nil with the absence of phenolphthalein alkalinity and dissolved oxygen. hardness was high with low nitrogen and phosphorus concentration. human consumable. acquatic macrophytes are cultivated in such waste water. net primary productivity of three macrophytes: ipomoea aquatica, marsilea quadrifolia and nelumbo nucifera were e ...200112017265
hepatoprotective and free radical scavenging effects of nelumbo nucifera.ethanol extracts from nelumbo nucifera (enn) seeds were studied for possible antioxidative and hepatoprotective effects. antioxidative effects were measured spectrophotometrically by reduction of 2,2'-diphenyl-1-picrylhydrazyl (dpph) radicals. hepatoprotective effects were tested using carbon tetrachloride (ccl4) and aflatoxin b1 (afb1)-induced hepatocyte toxicity models. enn showed potent free radical scavenging effects with a median inhibition concentration of 6.49 microg/ml. treatment of hepa ...200312725571
[hypotensive mechanism of the alkaloid nn-9 from nelumbo nucifera]. 196214075894
the extracts from nelumbo nucifera suppress cell cycle progression, cytokine genes expression, and cell proliferation in human peripheral blood mononuclear the hope of identifying agents of therapeutic value in tissue inflammation, we tested ethanolic extracts of six chinese herbs for their effects on human peripheral blood mononuclear cells (pbmc) proliferation in vitro. the results indicated that the extracts from nelumbo nucifera gaertn, used in treatment of tissue inflammation in traditional chinese medicine, inhibited pbmc proliferation activated with phytohemagglutinin (pha). by a bioassay-guided fractionation procedure, nn-b-4 identified ...200415172179
anti-hiv benzylisoquinoline alkaloids and flavonoids from the leaves of nelumbo nucifera, and structure-activity correlations with related alkaloids.(+)-1(r)-coclaurine (1) and (-)-1(s)-norcoclaurine (3), together with quercetin 3-o-beta-d-glucuronide (4), were isolated from the leaves of nelumbo nucifera (nymphaceae), and identified as anti-hiv principles. compounds 1 and 3 demonstrated potent anti-hiv activity with ec50 values of 0.8 and <0.8 microg/ml, respectively, and therapeutic index (ti) values of >125 and >25, respectively. compound 4 was less potent (ec50 2 microg/ml). in a structure-activity relationship study, other benzylisoquin ...200515598565
inhibitory effects of isoliensinine on bleomycin-induced pulmonary fibrosis in mice.the effects of isoliensinine (il), a bisbenzylisoquinoline alkaloid extracted from the chinese traditional medicine seed embryo of nelumbo nucifera gaertn., on bleomycin (blm)-induced pulmonary fibrosis in mice were investigated. seventy-two male kungming mice were divided randomly into eight groups as blm-il10, blm-il20, blm-il40, blm-sal, sal-il10, sal-il20, sal-il40 and sal-sal groups. blm (0.1 mg in 0.05 ml saline per animal, once) or saline (0.05 ml per animal, once) was applied intratrache ...200515770542
herpes simplex virus type 1 propagation in hela cells interrupted by nelumbo nucifera.inhibitory effects of ethanolic extracts from 10 chinese herbs on herpes simplex virus type 1 (hsv-1) replication were investigated. by a bioassay-guided fractionation procedure, nn-b-5 was identified from seeds of n. nucifera. nn-b-5 significantly blocked hsv-1 multiplication in hela cells without apparent cytotoxicity. to elucidate the point in hsv-1 replication where arrest occurred, a set of key regulatory events leading to the viral multiplication was examined, including hsv-1 dna synthesis ...200516132118
antioxidant activity of nelumbo nucifera (sacred lotus) seeds.antioxidant activity of hydro alcoholic extract of nelumbo nucifera seeds (hann) was studied using in vitro and in vivo models. total phenolic content in hann was found to be 7.61 +/- 0.04% (w/w). characteristic hptlc fingerprints of hann were also made using different solvent systems. the hann exhibited strong free radical scavenging activity as evidenced by the low ic(50) values in both dpph (1,1-diphenyl-2-picryl hydrazyl) (6.12 +/- 0.41 microg/ml) and nitric oxide (84.86 +/- 3.56 microg/ml) ...200616239089
inhibition of (s)-armepavine from nelumbo nucifera on autoimmune disease of mrl/mpj-lpr/lpr mice.t cell immune responses play important roles in the pathogenesis of systemic lupus erythematosus (sle). (s)-armepavine (c19h23o3n; mw313) from nelumbo nucifera suppresses t cells proliferation. to study its potential benefit on sle, we examined effects of (s)-armepavine on mrl/mpj-lpr/lpr mice, which have similar disease features to human sle. mrl/mpj-lpr/lpr mice were treated orally with (s)-armepavine for 6 weeks and their sle characteristics were evaluated. the results revealed that (s)-armep ...200616413531
anti-obesity effect of nelumbo nucifera leaves extract in mice and rats.the leaf of nelumbo nucifera gaertn. (family nymphaeaceae) has been used for summer heat syndrome as home remedy in japan and china, and it has recently been used to treat obesity in china. so we investigate the pharmacological mechanism of the anti-obesity effect of nelumbo nucifera leaves extract (nne). we examined the effect of nne on digestive enzyme activity, lipid metabolism and theromogenesis and evaluated the effects of anti-obesity using high-fat diet-induced obesity in mice that were t ...200616495025
evaluation of antioxidant activity and inhibitory effect on nitric oxide production of some common vegetables.the objectives of this study were to study the antioxidant activities and nitric oxide (no) scavenging effects of vegetables in vitro systems and to study the inhibitory effects of vegetables on the no production and no-induced dna damage in raw 264.7 macrophage. the results indicated that water extracts from indian lotus, jew's ear, shiitake, eggplant, and winter mushroom showed stronger antioxidant activity and free-radical-scavenging ability than that of other vegetable extracts. the scavengi ...200616506819
effects of isoliensinine on angiotensin ii-induced proliferation of porcine coronary arterial smooth muscle cells.the inhibitory effects of isoliensinine (il), a bisbenzylisoquinoline alkaloid extracted from the seed embryo of the traditional chinese medicinal herb nelumbo nucifera gaertn, on the proliferation of porcine coronary arterial smooth muscle cells (casmcs) induced by angiotensin ii(ang ii) and its mechanisms of action were investigated. counting cultured cell number, mtt assay, immunohistochemical method and western blot were adopted. ang ii 0.1 micromol l (-1) significantly evoked casmc prolifer ...200616864426
rat lens aldose reductase inhibitory constituents of nelumbo nucifera stamens.aldose reductase, the principal enzyme of the polyol pathway, has been shown to play an important role in the complications associated with diabetes. a methanol extract of the stamens of nelumbo nucifera gaertn. was shown to exert an inhibitory effect on rat lens aldose reductase (rlar), and thus was fractionated using several organic solvents, including dichloromethane, ethyl acetate and n-butanol. the ethyl acetate-soluble fraction, which manifested potent rlar-inhibitory properties, was then ...200616881021
down-regulation of inos and tnf-alpha expression by kaempferol via nf-kappab inactivation in aged rat gingival tissues.the primary objective of this study was to evaluate the ability and mechanism of action of kaempferol, which is contained in extracts from nelumbo nucifera, a well-known oriental herb used in traditional medicine, with regard to the inhibition of inos and tnf-alpha expression in aged rat gingival tissues. we conducted an investigation into the age-related effects of kaempferol on reactive oxygen species (ros) and gsh oxidative status in samples of aged gingival tissues. western blotting was cond ...200717278014
(s)-armepavine inhibits human peripheral blood mononuclear cell activation by regulating itk and plcgamma activation in a pi-3k-dependent manner.chinese herbs are useful edible and medicinal plants for their immune modulatory functions. we have proven that (s)-armepavine (c19h23o3n; mw313) from nelumbo nucifera inhibits the proliferation of human pbmcs activated with pha and improves autoimmune diseases in mrl/mpj-lpr/lpr mice. in the present study, the pharmacological activities of (s)-armepavine were evaluated in pha-activated pbmcs. the results showed that (s)-armepavine suppressed pha-induced pbmc proliferation and genes expression o ...200717284681
[pcr, clone and sequence analysis of rdna-its of nelumbo nucifera from different geographical origins in china].to provide dna molecular marker for identification of nelumbo nucifera by exploring the differences of nrdna-its sequence of n. nucifera originated from different habitats.200717608215
screening of indian medicinal plants for acetylcholinesterase inhibitory activity.the cholinergic hypothesis of alzheimer's disease (ad) has provided the rationale for the current pharmaco-therapy of this disease, in an attempt to reduce the cognitive decline caused by cholinergic deficits. nevertheless, the search for potent and long-acting acetylcholinesterase (ache) inhibitors that exert minimal side effects in ad patients is still ongoing. ache inhibitors are currently the only approved therapy for the treatment of alzheimer's disease; only a limited number of drugs are c ...200717639556
constituents from the leaves of nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice.nelumbo nucifera gaertn. (nymphaceae) has been used for various medicinal purposes as in chinese herbal medicine. in particular, the leaves are known for diuretic and astringent properties, and are used to treat obesity. during our search for a plant-derived anti-obesity agent from natural products, we have found that a 50% ethanol (etoh) extract prepared from the leaves of n. nucifera (nn) stimulated lipolysis in the white adipose tissue (wat) of mice and that the beta-adrenergic receptor (beta ...200717893829
effects of plant extract neferine on cyclic adenosine monophosphate and cyclic guanosine monophosphate levels in rabbit corpus cavernosum in further investigate the relaxation mechanism of neferine (nef), a bis-benzylisoquinoline alkaloid extracted (isolated) from the green seed embryo of nelumbo nucifera gaertn in china, on rabbit corpus cavernosum tissue in vitro.200818097520
chronic renal failure among farm families in cascade irrigation systems in sri lanka associated with elevated dietary cadmium levels in rice and freshwater fish (tilapia).chronic renal failure (crf), in the main agricultural region under reservoir based cascade irrigation in sri lanka has reached crisis proportion. over 5,000 patients in the region are under treatment for crf. the objective of this study is to establish the etiology of the crf. concentrations of nine heavy metals were determined in sediments, soils of reservoir peripheries, water and nelumbo nucifera (lotus) grown in five major reservoirs that supply irrigation water. all five reservoirs carried ...200818200439
[inhibitory effects of liquor cultured with nelumbo nucifera and nymphaea tetragona on the growth of microcystis aeruginosa].the inhibitory effects of liquor cultured with nelumbo nucifera and nymphaea tetragona on the growth of microcystis aeruginosa have been investigated by measuring the cell number and the chlorophyll a content of microcystis aeruginosa of culture in the laboratory. the results showed that the inhibitory effects on the growth of microcystis aeruginosa with different concentration of the liquor cultured with nelumbo nucifera and nymphaea tetragona were dissimilar, and an evident phenomenon appeared ...200718268975
novel effects of nelumbo nucifera rhizome extract on memory and neurogenesis in the dentate gyrus of the rat hippocampus.memory enhancement is a matter of concern in general, and in particular to people suffering from cognitive dysfunction. in this study, we investigated the effect of nelumbo nucifera rhizome extract on learning and memory function. a step-through passive avoidance test was performed with wistar rats. in addition, immunohistochemistry was used to investigate cell proliferation and differentiation in the dentate gyrus of the hippocampus. the methanol extract of n. nucifera rhizome (mnr) resulted in ...200818638527
changes in extreme high-temperature tolerance and activities of antioxidant enzymes of sacred lotus seeds.sacred lotus (nelumbo nucifera gaertn. 'tielian') seed is long-lived and extremely tolerant of high temperature. water content of lotus and maize seeds was 0.103 and 0.129 g h2o [g dw](-1), respectively. water content, germination percentage and fresh weight of seedlings produced by surviving seeds gradually decreased with increasing treatment time at 100 degrees c. germination percentage of maize (zea mays l. 'huangbaogu') seeds was zero after they were treated at 100 degrees c for 15 min and t ...200818726532
inhibitory effects of nelumbo nucifera leaves on rat lens aldose reductase, advanced glycation endproducts formation, and oxidative stress.the preventive and therapeutic potency against oxidative stress and diabetic complications of nelumbo nucifera were evaluated via the 1,1-diphenyl-2-picrylhydrazyl (dpph), trolox equivalent antioxidant capacity (teac), and total reactive oxygen species (ros) assays, as well as the rat lens aldose reductase (rlar) and advanced glycation endproducts (age) assays. the leaf extract of n. nucifera exerted potent antioxidant effects as well as marked inhibitory effects for rlar and age formation, corr ...200818952135
effects of extracts and neferine from the embryo of nelumbo nucifera seeds on the central nervous system.the effects of embryos of the seeds of nelumbo nucifera on the central nervous system were studied in mice. meoh extracts of embryos of nelumbo nucifera seeds significantly inhibited locomotor activity in mice. the meoh extract was successively partitioned between h(2)o and n-hexane, between h(2)o and chcl(3), and between h(2)o and n-buoh. chcl(3) extracts strongly inhibited locomotor activity in mice, although other extracts had no effect on locomotor activity. the main alkaloid of chcl(3) extr ...200819010651
molecular cloning and expression analysis of an mn-sod gene from nelumbo nucifera.a rapid amplification cdna end (race) assay was established to achieve the complete sequence of mitochondrial manganese-superoxide dismutase (mn-sod) cdna in nelumbo nucifera. the obtained full-length cdna of mn-sod was 926 bp and contained a 699-bp open reading frame encoding an mn-sod precursor of 233 amino acids. the recombinant of mn-sod expressed by pet-32a vector in escherichia coli bl21 was confirmed by sodium dodecyl sulfate polyacrylamide gel electrophoresis and western blotting assays. ...200919018482
simultaneous determination of quercetin and its glycosides from the leaves of nelumbo nucifera by reversed-phase high-performance liquid chromatography.the purpose of this study was to develop reversed-phase hplc method for the simultaneous determination of the flavonoids from the leaves of nelumbo nucifera, which have been known to exhibit antioxidant, anti-hiv, antihyperlipidemic and antiobesity effects. hplc separation was achieved on c(18) column using gradient elution with mobile phase consisting of acetonitrile-water containing 0.1% formic acid. the separated peaks were identified by electrospray ionization mass spectrometry. the hplc met ...200919280149
the sacred lotus (nelumbo nucifera) - phytochemical and therapeutic profile.nelumbo nucifera gaertn. (nymphaeaceae), also known as sacred lotus, is a well known medicinal plant. this article reviews the traditional uses, phytochemistry and therapeutic reports on different parts of n. nucifera viz. the seeds, rhizomes, leaves and flowers. this review also describes various compounds isolated from different parts of this plant and the therapeutic benefits derived from those phytoconstituents.200919298686
kaempferol isolated from nelumbo nucifera stamens negatively regulates fcepsilonri expression in human basophilic ku812f cells.mast cells and basophils perform important functions as pivotal effector cells in ige-mediated allergic reactions. ku812f cells, a human basophilic cell line isolated originally from chronic myelocytic leukemia, express a high affinity receptor of ige, fcepsilonri. kaempferol was extracted and isolated from a methanolic extract of flavonoid-rich nelumbo nucifera stamens. in the present study, the inhibitory effects of kaempferol on fcepsilonri expression in human basophilic ku812f cells was exam ...200919307764
blockade of herg k+ channel by isoquinoline alkaloid neferine in the stable transfected hek293 cells.we studied the effects of isoquinoline alkaloid neferine (nef) extracted from the seed embryo of nelumbo nucifera gaertn on human ether-à-go-go-related gene (herg) channels stably expressed in human embryonic kidney (hek293) cells using whole-cell patch clamp technique, western blot analysis and immunofluorescence experiment. nef induced a concentration-dependent decrease in current amplitude according to the voltage steps and tail currents of herg with an ic(50) of 7.419 microm (n(h) -0.5563). ...200919424681
nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression.nelumbo nucifera semen (nns) is a traditional herb with anti-diarrheal, anti-ganacratia, and tranquilizer-like pharmacological activities. in this study, we examined the anti-amnesic effect of nns on rats with scopolamine-induced amnesia. passive avoidance tests, acetylcholinesterase (ache) activity, and choline acetyltransferase (chat) expression were used to evaluate the nns anti-amnesic effects. the rats were divided into five groups: the normal group, scopolamine-treated group (1mg/kg; contr ...200919463889
neferine enhances insulin sensitivity in insulin resistant rats.neferine was isolated from green seed embryo of nelumbo nucifera gaertn which has been used as an anti-obesity agent in traditional chinese herbal medicine.200919527823
antioxidative effect and active components from leaves of lotus ( nelumbo nucifera ).the dpph scavenging effect, the inhibition of human low-density lipoprotein oxidation, and antioxidative contents were employed for the activity-guided purification to identify the antioxidant components of lotus leaves (leaves of nelumbo nucifera gaertn.). the methanolic extract of lotus leaves (llm) was separated into ethyl acetate (llme), n-butanol (llmb), and water (llmw) fractions. llme and llmb exhibited greater capacity to scavenge dpph radical, delayed ldl oxidation, and had higher antio ...200919572539
inhibitory effects of armepavine against hepatic fibrosis in rats.activation of hepatic stellate cells (hscs) plays a crucial role in liver fibrogenesis. armepavine (arm, c19h23o3n), an active compound from nelumbo nucifera, has been shown to exert immunosuppressive effects on t lymphocytes and on lupus nephritic mice. the aim of this study was to investigate whether arm could exert anti-hepatic fibrogenic effects in vitro and in vivo. a cell line of rat hscs (hsc-t6) was stimulated with tumor necrosis factor-alpha (tnf-alpha) or lipopolysaccharide (lps) to ev ...200919723340
extract from the leaf of nucifera reduced the development of atherosclerosis via inhibition of vascular smooth muscle cell proliferation and migration.nelumbo nucifera gaertn, a perennial aquatic plant, has been used as a medicinal herb in china and india. we have previously reported that consumption of nucifera leaf extract (nle) reduced the development of atherosclerosis in cholesterol-fed rabbits; however, the molecular mechanisms involved were unclear. atherosclerotic plaque is generated partly by proliferation and migration of vascular smooth muscle cells (vsmc). herein, we demonstrated that vsmc treated with nle-triggered apoptosis and a ...201019799955
bioactive compounds and antioxidant and antiproliferative activities of korean white lotus traditional korean medicine, lotus (nelumbo nucifera gaertn) roots have been used as an antidiabetic and an antiproliferative remedy. however, scientific publications on lotus properties are very limited. therefore, it was decided to investigate the korean white lotus cultivars in order to find out their bioactivity. it was found that all lotus cultivars (inchisa, muan, garam, and chungyang) possess high amounts of bioactive compounds: total phenols, between 7.95 +/- 0.8 and 4.21 +/- 0.3 mg o ...200919857070
comparative analysis of essential oil components and antioxidant activity of extracts of nelumbo nucifera from various areas of china.this study was designed to examine the composition of extracts and essential oil components from nelumbo nucifera leaves from the principal habitats in china. the amounts of phenolics, flavonoids, and proanthocyanidins in the lotus leaf extracts varied widely, ranging from 354 to 487 mg/g gallic acid equivalents, from 172 to 236 mg/g rutin equivalents, and from 124 to 179 mg/g catechin equivalents, respectively. all of the extracts had strong antioxidant activity in comparison to the standard co ...201019919095
sh21b, an anti-obesity herbal composition, inhibits fat accumulation in 3t3-l1 adipocytes and high fat diet-induced obese mice through the modulation of the adipogenesis pathway.sh21b is an anti-obesity composition composed of seven herbs: scutellaria baicalensis georgi, prunus armeniaca maxim, ephedra sinica stapf, acorus gramineus soland, typha orientalis presl, polygala tenuifolia willd and nelumbo nucifera gaertner. it has been used for the treatment of obesity in traditional medical clinics in korea, but its anti-obesity effects and mechanism of action have not been studied until now.201019963057
attenuation of acute and chronic restraint stress-induced perturbations in experimental animals by nelumbo nucifera gaertn.aqueous extract of leaves of nelumbo nucifera was investigated on acute stress (immobilization stress)-induced biochemical alterations in swiss mice. the animals were also subjected to acute physical stress (swimming endurance test) and acute chemical stress (writhing test) to gauge the antistress potential of the extract. further to evaluate the antistress activity of nelumbo nucifera in chronic stress condition, fresh wistar rats were subjected to cold restraint stress (4 degrees for 1 h) for ...200820046740
immunomodulatory potential of rhizome and seed extracts of nelumbo nucifera gaertn.nelumbo nucifera gaertn. (nymphaeaceae) is a well-known aquatic plant which has been used for the treatment of several disorders including skin disease, cough, inflammation, fever and many other disorders.201020079418
exploring the potential of nelumbo nucifera rhizome on membrane stabilization, mast cell protection, nitric oxide synthesis, and expression of costimulatory molecules.immunomodulatory activity of nelumbo nucifera rhizome was evaluated for its standardized extract (nnre) with respect to betulinic acid. various key parameters including erythrocyte membrane stabilization, inhibition of histamine release, reduction in nitric oxide production and depletion of expression of costimulatory molecules of macrophages were estimated. the result displayed that nnre stabilized erythrocyte membrane significantly at 10 (42.05%) and 100 microg/ml (44.31%). although considerin ...201020095810
antimutagenicity of some flowers grown in thailand.the mutagenicity of dichloromethane, methanol and water extracts of antigonon leptopus hook. & arn., curcuma sessilis gage, hibiscus rosa-sinensis linn., ixora coccinea linn., millingtonia hortensis linn., nelumbo nucifera gaertn., plumeria obtusa linn., punica granatum linn., rhinacanthus nasutus ((linn.) kurz.) and syzygium malaccense ((linn.) merr.& perry) before and after nitrite treatment was firstly investigated in the ames test. their antimutagenicity against the product of the reaction m ...201020100534
selective cholinesterase inhibitory activities of a new monoterpene diglycoside and other constituents from nelumbo nucifera stamens.a new beta-cyclogeraniol diglycoside (5), along with four known components, cycloartenol (1), p-hydroxybenzoic acid (2), vanilloloside (3), and 5'-o-methyladenosine (4), were first isolated from the n-buoh fraction of nelumbo nucifera stamens. the chemical structure of 5 was elucidated as 1-hydroxymethyl-2,6,6-trimethyl-1-cyclohexene 9-o-beta-d-glucopyranosyl-(1-->6)-beta-d-glucopyranoside (nuciferoside) on the basis of chemical and spectroscopic evidence, including 1d, 2d nmr, and ms. the anti- ...201020118551
evaluation of hypoglycemic activity of inorganic constituents in nelumbo nucifera seeds on streptozotocin-induced diabetes in rats.the seeds of nelumbo nucifera (lotus) have been used in the traditional system of medicine for various ailments including diabetes. the present study was aimed at analyzing the levels of biologically important trace elements in the lotus seeds by atomic absorption spectroscopy and evaluating the hypoglycemic properties of seed ash on streptozotocin-induced diabetes in rats. diabetic rats treated with lotus seed ash at a concentration of 200 mg/kg body weight orally for 30 days exhibited signific ...201020165930
antidepressant-like effects of neferine in the forced swimming test involve the serotonin1a (5-ht1a) receptor in mice.the effects of neferine, an alkaloid of nelumbo nucifera gaertner embryos, on immobility in the forced swimming test, which is used to evaluate antidepressants, were investigated in mice. the administration of neferine from 25 to 100 mg/kg i.p. elicited anti-immobility effects in mice. the molecular dose effects of neferine in the forced swimming test were almost equal to those of the typical antidepressants maprotiline and imipramine. the involvement of the 5-ht receptor subtypes was also studi ...201020176013
remediation of cadmium contaminated irrigation and drinking water: a large scale approach.cadmium is one of the most troublesome toxic heavy metals. it accumulates in the water reservoirs and agricultural soil as a result of intensive use of cd contaminated phosphate fertilizers, e.g. in agriculture in the north central province (ncp) of sri lanka. the hyper-accumulator thlaspi caerulescens, accumulates up to 1000 ppm cd in shoots without exhibiting toxicity symptoms. the storage rhizomes of year old nelumbo nucifera (lotus) natural vegetation in water reservoirs in ncp accumulated 2 ...201020466045
improvement in high-fat diet-induced obesity and body fat accumulation by a nelumbo nucifera leaf flavonoid-rich extract in mice.diets high in fat lead to excessive lipid accumulation in adipose tissue, which is a crucial factor in the development of obesity, hepatitis, and hyperlipidemia. in this study, we investigated the antiobesity effect of a flavonoid-enriched extract from nelumbo nucifera leaf (nlfe) in vivo. c57bl/6 mice were fed with a high-fat diet (hfd) to induce obesity. nlfe reduced the body weight, body lipid accumulation, and activities of fatty acid synthase (fas), glutamic oxaloacetic transaminase, and gl ...201020481471
(s)-armepavine from chinese medicine improves experimental autoimmune crescentic glomerulonephritis.intra-renal t cells and macrophages play a key pathogenic role in the development and progression of glomerular crescents. we aimed to establish (s)-armepavine [(s)-arm], a major bioactive compound of a chinese medicinal plant, nelumbo nucifera, as a potential therapeutic agent in the treatment of autoimmune crescentic glomerulonephritis (acgn).201020551296
in-vitro and in-vivo evaluations of cytochrome p450 1a2 interactions with nuciferine.the effects of nuciferine, a major active aporphine alkaloid from the leaves of nelumbo nucifera gaertn, on a cytochrome p450 1a2 (cyp1a2) probe substrate were investigated in vitro and in vivo.201020609070
lotus leaf extract and l-carnitine influence different processes during the adipocyte life cycle.abstract:201020687953
anti-amnesic activity of neferine with antioxidant and anti-inflammatory capacities, as well as inhibition of ches and bace1.the multifunctional potential of neferine derived from the embryo of nelumbo nucifera seeds for the age-related neurodegenerative disorders, in vivo anti-amnesic activities and in vitro cholinesterases (ches)- and β-site app cleaving enzyme 1 (bace1)-inhibitory activities, as well as anti-inflammatory and antioxidant activities were investigated.201020736023
antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet.nelumbo nucifera, known as sacred lotus, is a well-known medicinal plant and this lotus root is commonly used as food compared to different parts of this plant. this study was conducted to investigate the antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in high fat diet-induced obese rats.201020804615
antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet.lotus (nelumbo nucifera) leaf has been used to treat obesity. the purpose of this study was to investigate the antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in high fat diet-induced obese rats.201020804619
whole body radioprotective activity of an acetone-water extract from the seedpod of nelumbo nucifera gaertn. seedpod.procyanidins extracted with acetone-water from lotus (nelumbo nucifera gaertn.) seedpod (lspcs) were evaluated for in vivo radioprotective activity against whole body gamma irradiation in swiss albino mice. pretreated with lspcs 200 mg/kg by intragastric (i.g.) for 15 days was found to be the most effective dose in preventing radiation sickness, reducing radiation-induced mortality, increasing mean survival time and elevating radiation median lethal dose (ld(50)) from 8.9 to 10.5 gy, indicating ...201020837084
regulation of the 5-ht3a receptor-mediated current by alkyl 4-hydroxybenzoates isolated from the seeds of nelumbo nucifera.four known alkyl 4-hydroxybenzoates, i.e., methyl 4-hydroxybenzoate (1), ethyl 4-hydroxybenzoate (2), propyl 4-hydroxybenzoate (3), and butyl 4-hydroxybenzoate (4), were isolated from the seeds of nelumbo nucifera gaertner (nymphaeaceae) for the first time. the structures of the isolates were identified by 1d- and 2d-nmr spectroscopy and comparison with published values. the compounds were evaluated for their effects on the 5-ht-stimulated inward current (i(5-ht)) mediated by the human 5-ht(3)a ...201020860031
antioxidant activity of bovine and porcine meat treated with extracts from edible lotus (nelumbo nucifera) rhizome knot and leaf.lotus (nelumbo nucifera) is an extensively cultivated vegetable in eastern asia, particularly in china. both lotus rhizome knot (lrk) and lotus leaf (ll) are waste products of the lotus industry. extracts from lrk and ll are proposed as antioxidants for meat. porcine and bovine ground meat samples were subjected to three treatments: control (with no additives), lrk (lotus rhizomes knot extract 3% w/w), and ll (lotus leaf extract 3% w/w). raw and cooked samples were stored at 4°c and the antioxid ...201020869815
oxidative and color stability of cooked ground pork containing lotus leaf (nelumbo nucifera) and barley leaf (hordeum vulgare) powder during refrigerated storage.this study aimed to evaluate the oxidative and color stability of cooked ground pork containing lotus leaf powder at 0.1 (lp1) and 0.5% (lp2) as well as barley leaf powder at 0.1 (bp1) and 0.5% (bp2) during refrigerated storage for 10 days. the oxidative stability of these powders was compared with butylhydroxytoluene (bht). lp1 had higher a* and lower b* values than the control (-) over 4 days (p<0.05). the ph values of the ground pork samples made with addition of lp and bht decreased until da ...201120926202
neferine inhibits cultured hepatic stellate cell activation and facilitates apoptosis: a possible molecular mechanism.neferine is a major alkaloid component of "lian zi xin", embryos of the seeds of nelumbo nucifera gaertner, nymphaeaceae. previous studies have shown that neferine has an inhibitory effect on pulmonary fibrosis through its anti-inflammatory and anti-oxidative activities and inhibition of cytokines and nf-κb. however, it is unknown whether neferine also has an inhibitory effect on liver fibrosis through inhibition of tgf-β1 and collagen i and facilitation of apoptosis of hepatic stellate cells. t ...201020969858
rapid validated hptlc method for estimation of betulinic acid in nelumbo nucifera (nymphaeaceae) rhizome extract.betulinic acid (pentacyclic triterpenoid) is an important marker component present in nelumbo nucifera gaertn. rhizome. n. nucifera rhizome has several medicinal uses including hypoglycaemic, antidiarrhoeal, antimicrobial, diuretic, antipyretic, psychopharmacological activities.201021043041
effects of nelumbo nucifera rhizome extract on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia animal model.a large aquatic herb, nelumbo nucifera gaertn, has psychopharmacological effects similar to minor tranquillizers and antistress agents. this study examined the effects of nelumbo nucifera rhizome extracts (nre) on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus (dg) of a rat model of scopolamine-induced amnesia. immunohistochemical markers included ki67, an endogenous marker for active cell cycle, and doublecortin (dcx), a marker for immature neurons and migrat ...201021086545
immunoregulatory and anti-hiv-1 enzyme activities of antioxidant components from lotus (nelumbo nucifera gaertn) this study, two anti-oxidant micromolecular components ( l2f-2, l2f-3), and an antioxidant macromolecular component lb2, were extracted from lotus (nelumbo nucifera gaertn) rhizomes. mass spectrum (ms), fourier transform infrared spectroscopy (ftir) and nuclear magnetic resonance (nmr) were used to identify these compounds. l2f-2 was (+/-)-gallocatechin, l2f-3 was (-)-catechin and lb2 was a polysaccharide-protein complex with a molecular weight of 18.8 kda. lb2 was identified as a polysacchar ...201021114474
extract of lotus leaf ( nelumbo nucifera ) and its active constituent catechin with insulin secretagogue activity.the effect of lotus leaf ( nelumbo nucifera gaertn.) on diabetes is unclear. we hypothesized that lotus leaf can regulate insulin secretion and blood glucose levels. the in vitro and in vivo effects of lotus leaf methanolic extract (nne) on insulin secretion and hyperglycemia were investigated. nne increased insulin secretion from β cells (hit-t15) and human islets. nne enhanced the intracellular calcium levels in β cells. nne could also enhance phosphorylation of extracellular signal-regulated ...201121235242
acute and subchronic oral toxicity studies of nelumbo nucifera stamens extract in rats.since the use of nelumbo nucifera stamens in herbal medicines as well as in cosmetic products are highly prevalent in thailand and increasing worldwide, acute and subchronic toxicity studies to confirm the safe use of nelumbo nucifera stamens are warranted.201121291992
screening of traditional chinese medicinal plants for quorum-sensing inhibitors activity.the misuse of antibiotics has contributed to widespread development of antimicrobial resistance among clinically significant bacterial species. alternative approaches other than those using antibiotics are needed in the fight against infectious diseases. quorum sensing (qs) is an intercellular signaling and gene regulatory mechanism, which is used by a number of opportunistic pathogenic bacteria in determining virulence gene expression. the study of qs may yield another strategy for disease cont ...201121439518
protective effect of neferine on endothelial cell nitric oxide production induced by lysophosphatidylcholine: the role of the ddah-adma pathway.neferine, extracted from the seed embryo of nelumbo nucifera gaertn., has multiple cardiovascular pharmacological effects. the dimethylarginine dimethylaminohydrolase (ddah) - asymmetric dimethylarginine (adma) system is a novel pathway for modulating nitric oxide (no) production. the aim of this study was to investigate whether the protective effect of neferine on endothelial no production was related to the ddah-adma pathway. human umbilical vein endothelial cells (huvecs) were first exposed t ...201121526974
effects of neferine on the pharmacokinetics of amiodarone in rats.amiodarone, an iodinated benzofuran derivative with predominantly class iii anti-arrhythmic effects, is used to treat supraventricular and ventricular arrhythmias. the purpose of this study was to assess the potential of neferine, an effective anti-pulmonary fibrosis drug isolated from the embryo of nelumbo nucifera gaertner's seeds, to alter the pharmacokinetic profile of amiodarone. experimental sprague-dawley rats were randomly divided into two groups. in groups 1 and 2, amiodarone was given ...201121728182
Simultaneous determination of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn. in rat plasma by a rapid HPLC method and its application to a pharmacokinetic study.A rapid and specific HPLC method has been developed and validated for the simultaneous determination of liensinine (CAS 2586-96-1), isoliensinine (CAS 6817-41-0) and neferine (CAS 2292-16-2) in rat plasma. The sample was prepared by a liquid-liquid extraction with diethyl ether and the recovery was above 80% from the plasma for the three compounds. Chromatographic separation was achieved with a Hypersil BDS C18 column (4.0 mm x 250 mm, particle size 5 microm). A mobile phase consisting of methan ...201121827045
Efficacy of adulticidal and larvicidal properties of botanical extracts against Haemaphysalis bispinosa, Hippobosca maculata, and Anopheles subpictus.The aim of the present study was to investigate the adulticidal and larvicidal activity of dried leaf hexane, ethyl acetate, acetone, and methanol extracts of Nelumbo nucifera, Manilkara zapota, Ipomoea staphylina, and Acalypha indica against the adults of Haemaphysalis bispinosa (Acarina: Ixodidae), hematophagous fly Hippobosca maculata (Diptera: Hippoboscidae), and fourth instar larvae of malaria vector Anopheles subpictus (Diptera: Culicidae). Parasites were exposed to varying concentrations ...201121861064
polyphenolic extract of lotus root (edible rhizome of nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice.nonalcoholic fatty liver disease (nafld) is emerging as the most common liver disease of industrialized countries. thus, discovering food components that can ameliorate nafld is of interest. lotus root, the edible rhizome of nelumbo nucifera, contains high levels of polyphenolic compounds, and several health-promoting properties of lotus root have been reported. in this study, we tested whether feeding a polyphenolic extract of lotus root to db/db mice protects them from hepatic steatosis.201122067945
larvicidal and repellent activity of medicinal plant extracts from eastern ghats of south india against malaria and filariasis evaluate the larvicidal and repellent activities of ethyl acetate and methanol extracts of acacia concinna (a. concinna), cassia siamea (c. siamea), coriandrum sativum (c. sativum),cuminum cyminum (c. cyminum), lantana camara (l. camara), nelumbo nucifera (n. nucifera) phyllanthus amarus (p. amarus), piper nigrum (p. nigrum) and trachyspermum ammi (t. ammi) against anopheles stephensi (an. stephensi) and culex quinquefasciatus (cx. quinquefasciatus).201121967692
Documentation and determination of consensus about phytotherapeutic veterinary practices among the Tharu tribal community of Uttar Pradesh, India.PURPOSE: The aim of the present investigation was to document the phytotherapeutic knowledge and veterinary healthcare management practices among the Tharu tribal community of Uttar Pradesh, India and to determine the consensus of such practices, in order to evaluate the potential for new veterinary drugs of herbal origin. METHODS: This study was conducted in 2000-2004 using semistructured, open-ended questionnaires, informal interviews and group discussions with farmers engaged in animal husban ...201121927989
neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 mapk-mediated p21 stabilization.identification of natural products that have antitumor activity is invaluable to the chemoprevention and therapy of cancer. the embryos of lotus (nelumbo nucifera) seeds are consumed in beverage in some parts of the world for their presumed health-benefiting effects. in this report we studied the effects of neferine, a major alkaloid component in lotus embryos, on human osteosarcoma cells and the underlying mechanisms. we found that neferine possessed a potent growth-inhibitory effect on human o ...201122227330
biodiversity and importance of floating weeds of dara ismail, khan district of kpk, pakistan.the present paper is based on the results of taxonomic research work conducted in dera ismail khan district of kpk, pakistan, during 2005 - 2007. the area was extensively surveyed in order to collect floating aquatic weeds. from the study area 11 floating aquatic weed species belonging to 9 genera and 9 families were collected and identified in the light of available literature. these plants include bryophytes: 1 species, ricciocarpus natans (l.) corda; pteridophytes: 2 species, azolla pinnata r ...201122754062
[the application of cation exchange resins in the separation of total flavonoids and alkaloids from seed embryo of nelumbo nucifera].to explore the optimal separation condition of the total flavonoids and alkaloids from seed embryo of nelumbo nucifera.201223627099
molecular evolution and functional characterisation of an ancient phenylalanine ammonia-lyase gene (nnpal1) from nelumbo nucifera: novel insight into the evolution of the pal family in angiosperms.phenylalanine ammonia-lyase (pal; e.c. is a key enzyme of the phenylpropanoid pathway in plant development, and it catalyses the deamination of phenylalanine to trans-cinnamic acid, leading to the production of secondary metabolites. this enzyme has been identified in many organisms, ranging from prokaryotes to higher plants. because nelumbo nucifera is a basal dicot rich in many secondary metabolites, it is a suitable candidate for research on the phenylpropanoid pathway.201424884360
anthelmintic activities of aporphine from nelumbo nucifera gaertn. cv. rosa-plena against hymenolepis nana.nelumbo nucifera gaertn. cv. rosa-plena (nelumbonaceae), commonly known as lotus, is a perennial aquatic plant grown and consumed throughout asia. all parts of n. nucifera have been used for various medicinal purposes in oriental medicine. from the leaves of nelumbo nucifera gaertn. cv. rosa-plena (an aquatic plant), liriodenine (1), lysicamine (2), (-)-anonaine (3), (-)-asimilobine (4), (-)-caaverine (5), (-)-n-methylasimilobine (6), (-)-nuciferine (7), (-)-nornuciferine (8), (-)-roemerine (9), ...201424583851
antimicrobial efficacy of punica granatum mesocarp, nelumbo nucifera leaf, psidium guajava leaf and coffea canephora extract on common oral pathogens: an in-vitro study.alternative therapies are increasingly being explored as extensive use of synthetic chemicals has led to the emergence of substantial side effects. phytomedicine has been well practiced as traditional medicine in various cultures for treatment of oral diseases. it has gained importance of late as an alternative to the conventional therapy. various plant and fruit extracts have been monitored recently to assess their potential against the common oral pathogens. aim of this study was to assess in- ...201425177642
cloning a glutathione peroxidase gene from nelumbo nucifera and enhanced salt tolerance by overexpressing in rice.a full-length cdna clone encoding an 866 bp-length glutathione peroxidase protein (nngpx) was isolated from lotus (nelumbo nucifera l.). the deduced amino acid sequence of the nngpx gene had significant homology with atgpx6. a 3d structural model of the nngpx was constructed by homology modeling. the cloned nngpx gene was expressed in escherichia coli, and a fusion protein of about 40 kda was detected after isopropyl thiogalactoside induction. under different concentrations of na2seo3 treatments ...201424715609
neferine isolated from nelumbo nucifera enhances anti-cancer activities in hep3b cells: molecular mechanisms of cell cycle arrest, er stress induced apoptosis and anti-angiogenic response.hepatocellular carcinoma (hcc) is one of the most aggressive malignant diseases and is highly resistant to conventional chemotherapy. neferine, a major bisbenzylisoquinoline alkaloid derived from the embryos of nelumbo nucifera, has been reported a few physiological activities. however, the mechanisms of anticancer effects are not well understood and its detailed activities on hep3b cells have not been determined. our results suggest that neferine exhibited cytotoxicity against hcc hep3b cells, ...201323746959
enhanced microbial, functional and sensory properties of herbal yogurt fermented with korean traditional plant extracts.this study evaluated the effects of two korean traditional plant extracts (diospyros kaki thunb. leaf; dk, and nelumbo nucifera leaf; nn) on the fermentation, functional and sensory properties of herbal yogurts. compared to control fermentation, all plant extracts increased acidification rate and reduced the time to complete fermentation (ph 4.5). supplementation of plant extracts and storage time were found to influence the characteristics of the yogurts, contributing to increased viability of ...201627499669
an evaluation of the inhibitory effects against rotavirus infection of edible plant extracts.rotaviruses are the single most important cause of severe diarrhea in young children worldwide. the developments of specific, potent and accessible antiviral treatments that restrain rotavirus infection remain important to control rotavirus disease.201222834653
detoxifying effect of nelumbo nucifera and aegle marmelos on hematological parameters of common carp (cyprinus carpio l.).the objective of this study was to investigate the efficacy of nelumbo nucifera and aegle marmelos on common carp exposed to sub-lethal concentrations of combined heavy metals (5 ppm) under laboratory conditions. the fish were treated with nelumbo nucifera (500 mg/kg bwt) and aegle marmelos (500 mg/kgbwt) for 30 days as a dietary supplement. the blood biochemical parameters of the fish were evaluated by analyzing the level of red blood cells (rbc), packed cell volume (pcv), hemoglobin concentrat ...201021331178
irritant and sensitizing potential of some common indian cact' succulents, lichens and aquatic plants.irritant potential of 3 cacti, opuntia dilenii, rhispalis baccifera and cereus peruvians, and 4 succulents, euphorbia royleana, euphorbia antiquorum,sansevieria zeyilanica and agave sisalana was tested by rubbing their freshly exposed pulp 10 times on the forearm skin of 10 human voluntrees. opuntia dilenii, euphorbia antiquorum, rhispalis baccifera and agave sisalana produced transitory itching and burning or dermatitis in only one patient each, indicating that these plants are not highly irrit ...201728150662
effects of the four-herb compound anbp on wound healing promotion in diabetic mice.wound healing is a troublesome problem in diabetic patients. besides, there is also an increased risk of postsurgical wound complications for diabetic patient. it has been revealed that traditional chinese medicine may promote healing and inhibit scar formation, while the changes of morphology and physiology of wounds on such medicine treatment still remain elusive. in this study, we first used the ultralow temperature preparation method to produce mixed superfine powder from agrimonia pilosa (a ...201525795279
quantitative ethnomedicinal survey of medicinal plants given for cardiometabolic diseases by the non-institutionally trained siddha practitioners of tiruvallur district, tamil nadu, india.the burden of cardiometabolic diseases such as dyslipidemia, hyperglycemia, hypertension, visceral obesity and atherosclerotic cardiovascular diseases and the use of traditional medicine for the management of such diseases are high in india; hence there is a need to document and analyze such therapies.201627090346
synthesis of silver nanoparticles using nelumbo nucifera leaf extract and its larvicidal activity against malaria and filariasis vectors.the aim of this study was to investigate the larvicidal potential of the hexane, chloroform, ethyl acetate, acetone, methanol, and aqueous leaf extracts of nelumbo nucifera gaertn. (nymphaeaceae) and synthesized silver nanoparticles using aqueous leaf extract against fourth instar larvae of anopheles subpictus grassi and culex quinquefasciatus say (diptera: culicidae). nanoparticles are being used in many commercial applications. it was found that aqueous silver ions can be reduced by aqueous ex ...201120978795
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