| activation of inducible nitric oxide synthase by euonymus alatus in mouse peritoneal macrophages. | euonymus alatus (ea) has been used for tumor therapy. however, it is still unclear how this herb prevents the diseases in experimental models. nitric oxide (no) as a potent macrophage-derived effector molecule against a variety of tumors has received increasing attention. | 2002 | 11880120 |
| inhibitory effect of methanol extract of euonymus alatus on matrix metalloproteinase-9. | various extracts prepared from stems of euonymus alatus were tested for cytotoxic activity on human hepatocellular carcinoma cell line, hep3b cells using the xtt assay method. also, the extracts were investigated the inhibitory effects on matrix metalloproteinase (mmp)-9 activity using gelatin zymography. the methanol extract, hexane and ethyl acetate fraction exhibited weak cytotoxic activity (ic(50) of >100 microg/ml). however, butanol (ic(50)=65 microg/ml) and chloroform (ic(50)=85 microg/ml) ... | 2003 | 12576216 |
| inhibitory effects of scutellaria barbata d. don. and euonymus alatus sieb. on aromatase activity of human leiomyomal cells. | it is now well documented that a large proportion of breast tumors express their own aromatase. this intratumoral aromatase produces estrogen in situ and therefore may contribute significantly to the amount of estrogen to which the cell is exposed. thus it is not only important that aromatase inhibitors potently inhibit the peripheral production of estrogen and eliminate the external supply of estrogen to the tumor cell, but that they in addition potently inhibit intratumoral aromatase and preve ... | 2004 | 15518167 |
| novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism. | our previous studies have clearly shown that the angiogenic enzymes, matrix metalloproteinase (mmp) -2/9, are directly involved in human hepatic tumorigenesis and metastasis and suggest that the mmp-2/9 inhibitors, which have dual inhibitory activities on enzyme activity and transcription, represent the best candidates for achieving tumor regression. many anti-cancer drugs have strong cellular cytotoxicity and side effects, indicating that strong anti-cancer drugs that have no or minimal cytotox ... | 2004 | 15522912 |
| isolation of a gene encoding a 1,2-diacylglycerol-sn-acetyl-coa acetyltransferase from developing seeds of euonymus alatus. | 1,2-diacyl-3-acetyl-sn-glycerols (ac-tag) are unusual triacylglycerols that constitute the major storage lipid in the seeds of euonymus alatus (burning bush). these ac-tags have long-chain acyl groups esterified at both the sn-1 and sn-2 positions of glycerol. cell-free extracts of developing seeds of e. alatus contain both long-chain acyl-coa and acetyl-coa sn-1,2-diacylglycerol acyltransferase (dgat) activity. we have isolated a gene from developing seeds of euonymus alatus that shows a very h ... | 2004 | 15579902 |
| differential regulation of protein kinase c activity by modulating factors and euonymus alatus (thunb.) sieb in human myometrial and uterine leiomyomal smooth muscle cells. | human myometrial smooth muscle cells (msmc) showed high protein kinase c (pkc) activity when a maximal dose of pkc-activating phorbol ester was used, while uterine leiomyomal cells (ulmc) showed only 6-12% of pkc activity. msmc exhibited a low proliferation rate, whereas ulmc exhibited a high proliferation rate. these different cell types of msmc and ulmc responded to 10 u/ml thrombin, with a twofold stimulation of pkc activity. downregulation of pkc activity was found when msmc were treated wit ... | 2005 | 15823124 |
| euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in icr mice. | euonymus alatus (ea), known as a gui jeon wu in china, has been used as a folk medicine for regulating blood circulation, relieving pain, eliminating blood clot, and treating dysmenorrhea in asian countries. although ea has anecdotally ascertained to show the anti-hyperglycemic activity by enhancing insulin secretion, there is no sufficient experimental evidence for anti-hyperglycemic activity of ea. the purpose of this study was to investigate the preventive effect of 50% ethanol extract of ea ... | 2005 | 16095853 |
| euonymus alatus (thunb.) sieb induces apoptosis via mitochondrial pathway as prooxidant in human uterine leiomyomal smooth muscle cells. | euonymus alatus (thunb.) sieb (ea) is a traditional korean herbal medicine, commonly used to treat tumors in korea and china for centuries. our earlier studies have indicated that ea exhibits antitumor properties, but its mechanism remains to be elucidated. in this study, we evaluated the molecular mechanism of ea in a human uterine leiomyomal smooth muscle cell (ulsmc) line. water extracts of ea have been reported to not only function as antioxidants but also cause cytotoxic effect. we investig ... | 2006 | 16681771 |
| in vitro regeneration and agrobacterium-mediated genetic transformation of euonymus alatus. | an in vitro plant regeneration method and an agrobacterium tumefaciens-mediated genetic transformation protocol were developed for euonymus alatus. more than 60% of cotyledon and 70% of hypocotyl sections from 10-day-old seedlings of e. alatus produced 2-4 shoots on woody plant medium (wpm) supplemented with 5.0 mg/l 6-benzylaminopurine (ba) plus 0.2 mg/l alpha-naphthalene acetic acid (naa), and 77% of shoots produced roots on wpm medium with 0.3 mg/l naa and 0.5 mg/l indole-3-butyricacid (iba). ... | 2006 | 16733742 |
| alleviating effects of active fraction of euonymus alatus abundant in flavonoids on diabetic mice. | euonymus alatus (e. alatus) has been used as a folk medicine for diabetes in china for more than one thousand years. in order to identify major active components, effects of different fractions of e. alatus on the plasma glucose levels were investigated in normal mice and alloxan-induced diabetic mice. our results show that ethyl acetate fraction (etoac fr.) displayed significant effects on reducing plasma glucose. in oral glucose tolerance, etoac fr. at 17.2 mg/kg could significantly decrease t ... | 2008 | 18306456 |
| effects on lipid peroxidation and antioxidative enzymes of euonymus alatus in cultured rat hepatocytes. | the euonymus alatus (thunb.) sieb. has long been used as a crude drug. in this paper, we investigate the effects of e. alatus on cultured hepatocyte cell system and lipid peroxidation in hydrogen peroxide (h(2)o(2)) treatment conditions. the study covers the physiological activity (the antioxidative activity and the nitrite-scavenging effect) of e. alatus. h(2)o(2) that can produce intracellular free radical was used for inducer of the peroxidation of cellular lipids. treatment of e. alatus atte ... | 2009 | 19152553 |
| inhibitory activity of euonymus alatus against alpha-glucosidase in vitro and in vivo. | the major goal in the treatment of diabetes mellitus is to achieve near-normal glycemic control. to optimize both fasting blood glucose and postprandial glucose levels is important in keeping blood glucose levels as close to normal as possible. alpha-glucosidase is the enzyme that digests dietary carbohydrate, and inhibition of this enzyme could suppress postprandial hyperglycemia. the purpose of this study was to test the inhibitory activity of methanol extract of euonymus alatus on alpha-gluco ... | 2007 | 20368936 |
| a distinct dgat with sn-3 acetyltransferase activity that synthesizes unusual, reduced-viscosity oils in euonymus and transgenic seeds. | endosperm and embryo tissues from the seeds of euonymus alatus (burning bush) accumulate high levels of 3-acetyl-1,2-diacyl-sn-glycerols (actags) as their major storage lipids. in contrast, the aril tissue surrounding the seed produces long-chain triacylglycerols (lctags) typical of most other organisms. the presence of the sn-3 acetyl group imparts actags with different physical and chemical properties, such as a 30% reduction in viscosity, compared to lctags. comparative transcriptome analysis ... | 2010 | 20439724 |
| [effect of euonymus alatus on the blood glucose and hemorheology in the rat model of type 2 diabetes mellitus with blood stagnation]. | to explore the effect of euonymus alatus on the blood glucose and hemorheology in rat model of type 2 diabetes mellitus with blood stagnation (dmbs). | 2011 | 21368421 |
| metabolic engineering of saccharomyces cerevisiae to produce a reduced viscosity oil from lignocellulose. | acetyl-triacylglycerols (acetyl-tags) are unusual triacylglycerol (tag) molecules that contain an sn-3 acetate group. compared to typical triacylglycerol molecules (here referred to as long chain tags; lctags), acetyl-tags possess reduced viscosity and improved cold temperature properties, which may allow direct use as a drop-in diesel fuel. their different chemical and physical properties also make acetyl-tags useful for other applications such as lubricants and plasticizers. acetyl-tags can be ... | 2017 | 28331545 |
| defining the extreme substrate specificity of euonymus alatus diacylglycerol acetyltransferase, an unusual membrane bound o-acyltransferase. | euonymus alatus diacylglycerol acetyltransferase ( ea dact) synthesizes the unusually structured 3-acetyl-1,2-diacylgylycerols (acetyl-tags) found in the seeds of a few plant species. a member of the membrane-bound o-acyltransferase (mboat) family, ea dact transfers the acetyl group from acetyl-coa to sn -1,2 diacylglycerol (dag) to produce acetyl-tags. in vitro assays demonstrated that the enzyme is also able to utilize butyryl-coa and hexanoyl-coa as acyl donors, though with much less efficien ... | 2016 | 27688773 |
| the yeast atf1 acetyltransferase efficiently acetylates insect pheromone alcohols: implications for the biological production of moth pheromones. | many moth pheromones are composed of mixtures of acetates of long-chain (≥10 carbon) fatty alcohols. moth pheromone precursors such as fatty acids and fatty alcohols can be produced in yeast by the heterologous expression of genes involved in insect pheromone production. acetyltransferases that subsequently catalyze the formation of acetates by transfer of the acetate unit from acetyl-coa to a fatty alcohol have been postulated in pheromone biosynthesis. however, so far no fatty alcohol acetyltr ... | 2016 | 26801935 |
| a new flavan-3-ol lactone and other constituents from euonymus alatus with inhibitory activities on α-glucosidase and differentiation of 3t3-l1 cells. | bioassay-guided fractionation, based on inhibition of α-glucosidase, of euonymus alatus led to the isolation of a new compound, catechin lactone a (7), and seven known compounds (1-6 and 8). their structures were established on the basis of extensive 1d- and 2d-nmr experiments. the absolute configurations of compound 7 have been determined using vibrational circular dichroism spectroscopy. all these compounds were evaluated for their inhibition activities on α-glucosidase and differentiation of ... | 2013 | 22994383 |
| decision making by generalist and specialist aphids with the same genotype. | one idea to explain the high incidence of specialisation in phytophagous insects is that their nervous systems are simple and unable to efficiently recognise multiple host plants. here this 'neural limitations' hypothesis is tested using a generalist (the summer winged virginopara) and specialist (the autumn gynopara) morph of a single clone of the black bean aphid, aphis fabae, that are almost identical morphologically and have the same genotype. electrical monitoring of stylet behaviour and no ... | 2003 | 12837318 |
| korean medicine therapy as a substitute for chemotherapy for metastatic breast cancer: a case report. | a 46-year-old korean woman was diagnosed with stage iii breast cancer and underwent 8 cycles of neoadjuvant chemotherapy, breast conservation surgery and adjuvant radiotherapy. however, the cancer recurred in the right upper lung (rul) and the right pulmonary hilum after 8 months. the rul nodule was removed through a wedge resection, and the pathologic finding was revealed as a metastatic adenocarcinoma. adjuvant chemotherapy was recommended, but she refused it because she feared adverse reactio ... | 2017 | 25848354 |
| comparative deep transcriptional profiling of four developing oilseeds. | transcriptome analysis based on deep expressed sequence tag (est) sequencing allows quantitative comparisons of gene expression across multiple species. using pyrosequencing, we generated over 7 million ests from four stages of developing seeds of ricinus communis, brassica napus, euonymus alatus and tropaeolum majus, which differ in their storage tissue for oil, their ability to photosynthesize and in the structure and content of their triacylglycerols (tag). the larger number of ests in these ... | 2011 | 21851431 |
| multivariate forecasts of potential distributions of invasive plant species. | the fact that plant invasions are an ongoing process makes generalizations of invasive spread extraordinarily challenging. this is particularly true given the idiosyncratic nature of invasions, in which both historical and local conditions affect establishment success and hinder our ability to generate guidelines for early detection and eradication of invasive species. to overcome these limitations we have implemented a comprehensive approach that examines plant invasions at three spatial scales ... | 2009 | 19323195 |
| the protective effect of the active components of erpc on diabetic peripheral neuropathy in rats. | euonymus alatus, radix trichosanthis, panax notoginseng and coptis chinensis are popular plants used in traditional chinese medicine to treat diabetes. | 2017 | 28315720 |
| euonymus alatus: a review on its phytochemistry and antidiabetic activity. | euonymus alatus (e. alatus) is a medicinal plant used in some asian countries for treating various conditions including cancer, hyperglycemia, and diabetic complications. this review outlines the phytochemistry and bioactivities of e. alatus related to antidiabetic actions. more than 100 chemical constituents have been isolated and identified from e. alatus, including flavonoids, terpenoids, steroids, lignans, cardenolides, phenolic acids, and alkaloids. studies in vitro and in vivo have demonst ... | 2016 | 27642361 |
| lignans from the twigs of euonymus alatus (thunb.) siebold and their biological evaluation. | a new sesquilignan, euonymolin a (1), and six known lignans, (-)-de-o-methylmagnolin (2), (+)-de-o-methylepimagnolin a (3), (+)-syringaresinol (4), (+)-pinoresinol (5), (+)-medioresinol (6), and (+)-lariciresinol 4'-o-β-d-glucopyranoside (7), were isolated from the twigs of euonymus alatus (thunb.) siebold (celastraceae). the structures of the isolated compounds were elucidated based on spectroscopic analyses, including extensive 1d- and 2d-nmr techniques, hr-ms analysis and circular dichroism ( ... | 2016 | 27447684 |
| bioassay-guided isolation of antiproliferative triterpenoids from euonymus alatus twigs. | euonymus alatus (celastraceae) has been used as an anticancer agent in korean traditional medicine. however, the potential bioactive contributors to the anticancer effects have not been thoroughly studied. our screening test revealed that the meoh extract of e. alatus twigs exhibited significant cytotoxicity against a549, sk-ov-3, and sk-mel-2 cell lines. a bioassay-guided separation of the meoh extract of e. alatus twigs resulted in the isolation and identification of 14 triterpenes as main phy ... | 2015 | 26749829 |
| chemical constituents from twigs of euonymus alatus. | to investigate the chemical compounds from the twigs of euonymus alatus, nine compounds were isolated and identified as(+)-delta(2,11)-enaminousnic acid(1), 11-keto-beta-boswellic acid(2), acetyl 11-keto-beta-boswellic acid(3), camaldulenic acid(4), betulinic acid(5), 6beta-hydroxy-stigmast-4-en-3-one(6), 5-hydroxy-6,7-dimethoxyflavone(7), ethyl 2,4-dihydroxy-6-methylbenzoate(8), 4,4'-dimethoxy-1,1'-biphenyl(9). their structures were elucidated by extensive spectroscopic analysis. among them, co ... | 2015 | 26697687 |
| chemical constituents of euonymus alatus (thunb.) sieb. and their ptp1b and α-glucosidase inhibitory activities. | phytochemical study on the corks of euonymus alatus resulted in the isolation of a novel 3-hydroxycoumarinflavanol (23), along with ten triterpenoids (1-10), ten phenolic derivatives (11-20), and two flavonoid glycosides (21 and 22). their structures were determined by extensive 1d and 2d-nuclear magnetic resonance spectroscopic and mass spectrometry data analysis. furthermore, their inhibitory effects against the protein tyrosine phosphatases 1b (ptp1b) and α-glucosidase enzyme activity were ev ... | 2015 | 26172104 |
| metabolic engineering of oilseed crops to produce high levels of novel acetyl glyceride oils with reduced viscosity, freezing point and calorific value. | seed oils have proved recalcitrant to modification for the production of industrially useful lipids. here, we demonstrate the successful metabolic engineering and subsequent field production of an oilseed crop with the highest accumulation of unusual oil achieved so far in transgenic plants. previously, expression of the euonymus alatus diacylglycerol acetyltransferase (eadact) gene in wild-type arabidopsis seeds resulted in the accumulation of 45 mol% of unusual 3-acetyl-1,2-diacyl-sn-glycerols ... | 2015 | 25756355 |
| phenolic constituents from the twigs of euonymus alatus and their cytotoxic and anti-inflammatory activity. | a bioassay-guided fractionation and chemical investigation of the meoh extract of the twigs of euonymus alatus resulted in the isolation and identification of five new phenolic compounds, named alatusols a-e (1-5), together with six known compounds (6-11). the structures of these new compounds were elucidated through spectral analysis, including extensive 2d-nmr data, and their absolute configurations were determined by the modified mosher's method. compounds 1-3 and 7-9 showed consistent cytoto ... | 2013 | 23468311 |
| euonymus alatus in the treatment of diabetic nephropathy in rats. | diabetic nephropathy is a leading cause of chronic renal failure. recently, euonymus alatus showed therapeutic potential in the treatment of diabetes and its chronic complications. in this study, effects of euonymus alatus and its mechanism in the treatment of diabetic nephropathy were investigated. diabetic nephropathy was induced in sprague-dawley rats by uninephrectomy plus streptozotocin (stz) administration. euonymus alatus and irbesartan, as a positive control, were lavaged to these rats f ... | 2012 | 23227790 |
| inhibition of nitric oxide production in lipopolysaccharide-stimulated raw264.7 macrophage cells by lignans isolated from euonymus alatus leaves and twigs. | the 80% methanolic extract of euonymus alatus leaves and twigs afforded three new lignans, (-)-threo-4,9,4',9'-tetrahydroxy-3,7,3',5'-tetramethoxy-8-o-8'-neolignan (1), (-)-threo-4,9,4',9'-tetrahydroxy-3,5,7,3'-tetramethoxy-8-o-8'-neolignan (2), (7r,8r,7'r)-(+)-lyoniresinol (3), together with seventeen known lignans (4-20). the structures of 1-20 were elucidated by extensive 1d and 2d spectroscopic methods including (1)h nmr, (13)c nmr, (1)h-(1)h cosy, hmqc, hmbc and noesy. all the isolated comp ... | 2011 | 21435874 |
| inhibitory constituents of euonymus alatus leaves and twigs on nitric oxide production in bv2 microglia cells. | the excessive and prolonged nitric oxide (no) production has been linked to various inflammatory diseases as well as tumourigenesis. on the search for anti-inflammatory and anti-cancer compounds from the medicinal plants, the methanolic extract of euonymus alatus (thunb.) sieb. (celastraceae) was found to have significant inhibitory activity on no production in lipopolysaccharide (lps)-stimulated bv2 microglia cells. hence, we attempted to isolate the inhibitory constituent of e. alatus leaves a ... | 2011 | 21426922 |
| euonymus alatus extract attenuates lps-induced nf-κb activation via ikkβ inhibition in raw 264.7 cells. | the present study was performed to investigate the underlying mechanisms of anti-inflammatory effects with the extract of euonymus alatus (eea), and specially focused on nuclear factor κb (nf-κb) signaling pathway by targeting the iκb kinase β (ikkβ). | 2011 | 21182917 |
| [determination of aromadendrin in euonymus alatus by hplc]. | to establish a hplc method to determine the content of aromadendrin in euonymus alatus. | 2010 | 21174766 |
| microwave-assisted extraction of rutin and quercetin from the stalks of euonymus alatus (thunb.) sieb. | euonymus alatus (thunb.) has been used as one of traditional chinese medicines for several thousand years. conventional methods for the extraction of rutin and quercetin from e. alatus, including solvent extraction, soxhlet extraction and heat reflux extraction are characterised by long extraction times and consumption of large amounts of solvents. | 2013 | 19086093 |
| total phenolics level, antioxidant activities and cytotoxicity of young sprouts of some traditional korean salad plants. | the aim of this investigation was to study the antioxidant and anticancer activities of young sprouts of some traditional korean salad plants. total phenolics, antioxidant and anticancer activities of the methanol extracts from young sprouts of 11 salad plants were determined. the highest amount of phenolics was found in methanol extracts of euonymus alatus (235.7 mg kg(-1)), followed by hypericum ascyron (197.1 mg kg(-1)), zanthoxylum piperitum (194.1 mg kg(-1)) and zanthoxylum schinifolium (14 ... | 2009 | 19016328 |
| [determination of total flavones from euonymus alatus sieb by microwave-assisted extraction and absorption spectroscopy]. | determination of total flavones from euonymus alatus sieb by microwave-assisted extraction and absorption spectroscopy was reported. the effects of solvent concentration, ratio of solution to solid, microwave power and radiation time were evaluated by single factor and orthogonal experiments. the extraction conditions of flavones from euonymus alatus sieb by microwave-assisted method were optimized as 40 : 1 of the weight ratio of 60% (v/v) ethanol to twigs and microwave power of 255 w for 5 min ... | 2008 | 18844177 |
| [studies on chemical constituents from euonymus alatus ii]. | to study the chemical constituents and antitumor activities of euonymus alatus. | 2008 | 18837347 |
| kaempferol and quercetin isolated from euonymus alatus improve glucose uptake of 3t3-l1 cells without adipogenesis activity. | euonymus alatus as a folk medicine in china has been clinically used to treat type 2 diabetes for many years, and also exerts beneficial effects on hyperglycemia of diabetic animals. our previous studies have isolated kaempferol and quercetin from the extract of e. alatus. in the present study, we investigated the possible mechanism of antidiabetic activity of these compounds. kaempferol and quercetin could significantly improve insulin-stimulated glucose uptake in mature 3t3-l1 adipocytes. in a ... | 2008 | 18262572 |
| ultrasound-assisted extraction of rutin and quercetin from euonymus alatus (thunb.) sieb. | an ultrasonic method for the extractions of rutin and quercetin from euonymus alatus (thunb.) sieb was investigated. the influence of four extraction variables on extraction yield of rutin and quercetin was discussed. the optimum extraction conditions found were: 70% aqueous ethanol; solvent: sample ratio 40:1 (v/w); extraction time 3 x 30 min. the recovery of rutin and quercetin and the reproducibility of the extraction method were determined. the optimized ultrasonic extraction conditions were ... | 2008 | 17606398 |
| [determination of elements in euonymus alatus by microwave digestion-icp-aes]. | the determination of elements in euonymus alatus by icp-aes was carried out in the present paper. the euonymus alatus samples were digested by microwave digestion technique. the optimized conditions of microwave digestion procedure obtained by orthogonal array design were as follows: the volume ratio of hno3-hcl is 2 : 1; the ratio of liquid/solid is 100 : 1; the sample particle size is 100-140 mesh. icp-aes method was applied to the determination of ten trace elements in the sample, and was com ... | 2006 | 17058968 |
| [the recent research situation of euonymus alatus]. | the functions of euonymus alatus in herbal canon, are removing blood stasis, restoring menstrual flow and killing worms, especially for gynecological diseases. the recently researches show e. alatus can depress blood sugar and blood lipid, resist hypersusceptibility, regulate immunity, and calcium abundant. it is effective for diabetes, hyperglycemia, chronic nephropathy, rheumatoid arthritis, urinary tract infection and prostate diseases, etc internal diseases, no matter singleness or together ... | 2005 | 16494017 |
| a phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor: isolation and identification from methanol extract of euonymus alatus. | a phenolic compound responsible for anti-mmp-9, which is known to be involved in tumor cell invasion and metastasis, has been isolated from methanol extracts prepared from stem barks of euonymus alatus by assay-guided fractionation. the compound has been identified as 5-caffeoylquinic acid (chlorogenic acid; cha) by nmr and fab-ms. cha showed a strong inhibitory effect of matrix metalloproteinase (mmp)-9 activity in a concentration-dependent manner on zymography. the purified cha inhibited mmp-9 ... | 2005 | 16005473 |
| a new matrix metalloproteinase-9 inhibitor 3,4-dihydroxycinnamic acid (caffeic acid) from methanol extract of euonymus alatus: isolation and structure determination. | in a previous paper [cha, b.y., park, c.j., lee, d.g., lee, y.c., kim, d.w., kim, j.d., seo, w.g., moon, s.k., kim, c.h., 2003. inhibitory effect of methanol extract from euonymus alatus on matrix metalloproteinase-9, j. ethnopharm. 85, 163-167], methanol extracts prepared from stems of euonymus alatus showed a strong inhibitory effect of matrix metalloproteinase (mmp)-9 activity, which is known to be involved in tumor cell invasion and metastasis, in a concentration-dependent manner on zymograp ... | 2005 | 15664266 |
| large-scale and effective screening of korean medicinal plants for inhibitory activity on matrix metalloproteinase-9. | matrix metalloproteinase-9 (mmp-9) degrades type iv collagen constituting the major structural component of the basement membrane and extra cellular membrane. the enzymatic activity is found to be elevated in tumor tissues. with the aim of finding novel mmp-9 inhibitors from natural products, 87 extracts of oriental medicinal herbs, which are used as prescriptions for cancer treatment in traditional korean medicine, were screened for their inhibitory activities towards mmp-9. it was found that m ... | 2005 | 15652283 |
| [comparison of spatholobus suberectus dum, euonymus alatus (thunb.) sieb. and eupolyphaga sinensis walker on regulation of plasma lipid]. | the spatholobus suberectus (ss) of hexue type, the euonymus alatus (ea) of huoxue type and the eupolyphaga sinensis (es) of poxue type were selected and their influence on plasma lipid in the experimental hyperlipidemia quails was observed. the es could raise plasma hdl-c/tc ratio and increase lcat activity. the ss could raise plasma hdl2-c/hdl3-c ratio. the effect of ea on plasma hdl-c/tc, hdl2-c/hdl3-c and lcat levels was between ss and es. all the three huoxue huayu chinese drugs could lower ... | 1991 | 1781900 |