regulation of expression of a wound-inducible tomato inhibitor i gene in transgenic nightshade plants.a wound-inducible proteinase inhibitor i gene from tomato containing 725 bp of the 5' region and 2.5 kbp of the 3' region was stably incorporated into the genome of black nightshade plants (solanum nigrum) using an agrobacterium ti plasmid-derived vector. transgenic nightshade plants were selected that expressed the tomato inhibitor i protein in leaf tissue. the leaves of the plants contained constitutive levels of the inhibitor protein of up to 60 micrograms/g tissue. these levels increased by ...19902102819
neuropharmacological activity of solanum nigrum fruit.the ethanol extract of the fruit of solanum nigrum l. (solanaceae) was studied for its neuropharmacological properties on experimental animals. on intraperitoneal injection, the extract significantly prolonged pentobarbital-induced sleeping time, produced alteration in the general behavior pattern, reduced exploratory behavior pattern, suppressed the aggressive behavior, affected locomotor activity and reduced spontaneous motility. the observations suggest that the fruit of s. nigrum possesses p ...19989720610
on the pathogenicity of attenuated schistosoma mansoni cercariae released from metabolically disturbed biomphalaria alexandrina.biomphalaria alexandrina were treated with sublethal concentrations (lc10) of dry powdered leaves solanum nigrum or whole dry ambrosia maritima. the two plants affected the development of schistosome parasite within snails by disturbing the glycolytic flux, the most important metabolic pathway for schistosome-infected snails. attenuated cercariae released from treated snails were used to infect male albino mice to evaluate their pathogenicity compared to control cercariae shed from untreated sna ...200314708853
effect of the leafy vegetable solanum nigrum on the activities of some liver drug-metabolizing enzymes after aflatoxin b1 treatment in female rats.wistar albino female rats were maintained for 10 d on diets containing various levels of the vegetable solanum nigrum. simultaneously, they received daily intraperitoneal injections of aflatoxin b1 (afb1) (either 0.2 or 0.4 mg/kg body-weight) diluted in propylene glycol. at the end of the experiment, all animals were killed and their serum and hepatic microsomes were prepared for assay of enzymes. results showed that aminopyrine n-demethylase activity increased 2.5-fold with 200 (s200) and 600 ( ...19911900029
antineoplastic agents. iii: steroidal glycosides from solanum bioactivity-guided fractionation, three known steroidal glycosides, beta 2-solamargine (1), solamargine (2), and degalactotigonin (3), were isolated from solanum nigrum. compounds 1-3 induced morphological abnormality in pyricularia oryzae mycelia with mmdc (minimum morphological deformation concentration) values of 63.0, 38.5, and 97.2 microm, respectively. this is the first report on the isolation of 1 from this species and on the cytotoxicity of 1-3 on six cultured human solid tumor cell l ...199910083842
differential expression of a chimeric camv-tomato proteinase inhibitor i gene in leaves of transformed nightshade, tobacco and alfalfa plants.the open reading frame and terminator region of a wound-inducible tomato inhibitor i gene, regulated by the camv 35s promoter, was stably integrated into the genomes of nightshade (solanum nigrum), tobacco (nicotiana tabacum), and alfalfa (medicago sativa), using an agrobacterium-mediated transformation system. the expression of the foreign inhibitor i gene in leaves of each species was studied at the mrna and protein levels. the levels of inhibitor i protein present in leaves of each species co ...19921463848
effect of dried fruits of solanum nigrum linn against ccl4-induced hepatic damage in rats.ethanol extract of solanum nigrum linn was investigated for its hepatoprotective activity against ccl4-induced hepatic damage in rats. the ethanol extract showed remarkable hepatoprotective activity. the activity was evaluated using biochemical parameters such as serum aspartate amino transferase (ast), alanine amino transferase (alt), alkaline phosphatase (alp) and total bilirubin. the histopathological changes of liver sample in treated animals were compared with respect to control.200314600413
ripe fruit of solanum nigrum l. inhibits cell growth and induces apoptosis in mcf-7 cells.solanum nigrum l. (snl) has been traditionally used as a herbal plant, whose fruit is believed to have anti-tumor properties, although the mechanism for the activity remains to be elucidated. in this study, we prepared an ethanol extract from ripe fruits of snl and investigated the mechanism involved in its growth-inhibitory effect on mcf-7 human breast cancer cells. results from proliferation assay using tritium uptake showed that the proliferative capacity of mcf-7 cells was strongly suppresse ...200312909277
homeologous plastid dna transformation in tobacco is mediated by multiple recombination events.efficient plastid transformation has been achieved in nicotiana tabacum using cloned plastid dna of solanum nigrum carrying mutations conferring spectinomycin and streptomycin resistance. the use of the incompletely homologous (homeologous) solanum plastid dna as donor resulted in a nicotiana plastid transformation frequency comparable with that of other experiments where completely homologous plastid dna was introduced. physical mapping and nucleotide sequence analysis of the targeted plastid d ...199910388829
mutations conferring lincomycin, spectinomycin, and streptomycin resistance in solanum nigrum are located in three different chloroplast genes.a number of solanum nigrum mutants resistant to the antibiotics spectinomycin, streptomycin and lincomycin have been isolated from regenerating leaf strips after mutagenesis with nitroso-methylurea. selection of streptomycin- and spectinomycin-resistant mutants has been described earlier. lincomycin-resistant mutants show resistance to higher levels of the antibiotic than used in the initial selection, and in the most resistant mutant (l17a1) maternal inheritance of the trait was demonstrated. t ...19948152418
in vitro evaluation of inhibitory nature of extracts of 18-plant species of chhindwara against 3-keratinophilic fungi.effect of extract of 18 plant species, viz., acorus calamus, adhatoda vasica, amomum subulatum, andrographis paniculata, boerhaavia diffusa, cassia occidentalis, centella asiatica, cymbopogon citratus, hemidesmus indicus, hyptis suaveolens, malvestrum sp., passiflora edulis, pergularia daemia, peristrophe bicalyculata, shuteria hirsuta, solanum nigrum, tecoma stans, and verbascum chinense on the growth of microsporum gypseum, chrysosporium tropicum and trichophyton terrestre was evaluated and di ...199710386016
susceptibility of biomphalaria alexandrina to infection with schistosoma mansoni: correlation with the activity of certain glycolytic enzymes.the importance of the glycolytic flux for the success of biomphalaria-schistosome sporocyst interaction was acertained in this study. hexokinase (hk), pyruvate kinase(pk), glucose phosphate isomerase(gpi) and lactate dehydrogenase (ld) as four important glycolytic enzymes were markedly stimulated in trematode infected biomphalaria alexandrina when measured two weeks post exposure to infection with schistosoma mansoni miracidia. on the other hand phosphoenolpyruvate carboxy kinase (pepck), glucos ...200010946515
evaluation of the gastric antiulcerogenic effects of solanum nigrum, brassica oleracea and ocimum basilicum in rats.antiulcerogenic activities of three plant drugs were studied against aspirin-induced gastric ulcers in rats. in addition, their effects on output of gastric acid and pepsin and hexosamine concentrations in gastric fluid were recorded in ulcerated and non-ulcerated rats. solanum nigrum (aerial parts) powder and its methanolic extract decreased the ulcer index significantly. the activity may be due to inhibition of acid and pepsin secretions and/or their in vitro ability to bind these. brassica ol ...19892515396
protease inhibitors and carcinoma of the esophagus.squamous cell carcinoma of the esophagus is endemic in parts of south africa. previous case-control studies have shown many associations but no clear etiologic pathway has been established.19989690530
preliminary evaluation of some wild and cultivated plants for snail control in machakos district, kenya.fifty local medicinal, agricultural and wild growing deciduous plants, representing 49 species, 46 genera and 22 families, were screened as water extracts at 1:1000 concentration for molluscicidal activity against biomphalaria pfeifferi in machakos district, kenya. forty-seven of the 50 (94%) plants and 106 of the 134 (79%) plant materials (roots, stems, leaves, fruits, flowers and seeds) were molluscicidal. the leaves of pappea capensis (sapindaceae), steganotaenia araliacea (umbelliferae), zor ...19873656497
rapid, random evolution of the genetic structure of replicating tobacco mosaic virus populations.the effects of temperature and type of host on the evolution of variants in replicating populations of tobacco mosaic virus (tmv) originating from an in vitro rna transcript of a cdna clone were studied. the phenotypic markers measured were temperature-sensitive (ts) replication and induction of necrotic local lesions (nl) on nicotiana sylvestris. the proportions of ts variants were about the same under all conditions tested, but changes in temperature or host had strong effects on proportions o ...19892777537
studies on the molluscicidal and larvicidal properties of solanum nigrum l. leaves ethanol extract.toxicological studies on three ethanol extract preparations of solanum nigrum l. leaves were made on biomphalaria alexandrina. extract (a), made by soaking leaves powder over night in cold 70% ethanol, has the highest activity, (lc50 3.37 mg/l within 24 hr). this extract also showed larvicidal activity against larvae of two mosquito species, aedes caspius and culex pipiens, (lc50 51.29 and 125.89 mg/l within 24 hr, and 21.38 and 38.11 mg/l within 48 hr, respectively). sunlight, ph, and turbidity ...200111775110
a 150-kda glycoprotein isolated from solanum nigrum l. has cytotoxic and apoptotic effects by inhibiting the effects of protein kinase c alpha, nuclear factor-kappa b and inducible nitric oxide in hct-116 cells.this study was carried out to investigate the anticancer effects of a 150-kda glycoprotein isolated from solanum nigrum l. (snl glycoprotein) on spontaneously and experimentally induced tumor promotion in hct-116 cells. for spontaneously induced tumor promotion, we evaluated the cytotoxic and apoptotic effects in hct-116 cells using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide (mtt), dna fragmentation, and h33342 and ethidium bromide staining assays. snl glycoprotein had remarka ...200415349752
glycoprotein isolated from solanum nigrum l. inhibits the dna-binding activities of nf-kappab and ap-1, and increases the production of nitric oxide in tpa-stimulated mcf-7 cells.solanum nigrum l. (snl) has been used in traditional folk medicine to treat numerous cancers. we isolated a glycoprotein (150 kda) from snl and tested its effect on the modulation of transcriptional factors (nf-kappa b and ap-1) and ino production in tpa induced-mcf-7 cells, which are part of the human breast cancer cell line, without estrogen receptors. however, the mechanism of snl glycoprotein in pharmacological and biochemical actions in cancer cells has not been studied. to test the effect ...200415465640
expression of the phytophthora infestans ipib and ipio genes in planta and in vitro.the ipib and ipio genes of the potato late blight fungus phytophthora infestans (mont.) de bary were isolated from a genomic library in a screen for genes induced in planta. expression of these genes was studied during pathogenesis on various host tissues and different host plants, some of which show specific resistance against p. infestans infection. during pathogenesis on leaves and tubers of the fully susceptible potato cultivar (cv.) ajax and on leaves of the fully susceptible tomato cv. mon ...19948058038
a case-control study of diet and social factors in cancer of the esophagus in transkei.a study of 100 patients with cancer of the esophagus and 100 controls matched for sex, age, and educational level was done in transkei, with extensive inquiries into diet and social habits. the significant risk factors found were use of solanum nigrum as a food (relative risk, 3.6), smoking (relative risk, 2.6), and use of traditional medicines (relative risk, 2.1). consumption of traditional beer was not a risk factor.19921735077
evaluation of the cytotoxicity, mutagenicity and antimutagenicity of emerging edible plants.this study evaluates the toxic, mutagenic and antimutagenic effects of emerging edible plants that are consumed as new leafy vegetables in taiwan. among eight plant extracts, only the extracts of sol (solanum nigrum l.) showed cytotoxicity to salmonella typhimurium ta100 in the absence of s9 mix. the toxicity of extracts from different parts of the sol plant, such as leaf and stem, immature fruit and mature fruit, towards s. typhimurium ta100 and human lymphocytes was also assayed. the immature ...200111527563
ultrastructural effects of aal-toxin ta from the fungus alternaria alternata on black nightshade (solanum nigrum l.) leaf discs and correlation with biochemical measures of toxicity.ultrastructural effects of aal-toxin ta from alternaria alternata on black nightshade (solanum, nigrum l.) leaf discs and correlation with biochemical measures of toxicity. in black nightshade (solanum nigrum l.) leaf discs floating in solutions of aal-toxin ta (0.01-200 microm) under continuous light at 25 degrees c, electrolyte leakage, chlorophyll loss, autolysis, and photobleaching were observed within 24 h. electrolyte leakage, measured by the conductivity increase in the culture medium, be ...19989839666
laboratory assessment of the molluscicidal and cercaricidal activities of the egyptian weed, solanum nigrum l.the molluscicidal properties of solanum nigrum l. were tested against three egyptian snail species (biomphalaria alexandrina, bulinus truncatus and lymnaea natalensis), each an intermediate host of parasites causing human schistosomiasis or fascioliasis. the plant was collected in two regions within egypt: fayium and giza. snails were exposed for 24 and 48 h, to the dry powdered fruits and leaves or to crude water extracts of the powders, and mortality was recorded. the water extract of the leav ...19979579213
acetylcholine-like activity in the fruit of the black nightshade (solanaceae).the presence of acetylcholine in aqueous extracts of the fruit of solanum nigrum linn. (black nightshade) has been established based upon the following pharmacological tests: a) isotonic contraction of the isolated toad rectus abdominis; b) negative chronotropic and inotropic action on the isolated toad heart; c) isotonic contraction of the isolated guinea pig's ileum; d) isotonic contraction of the rat's isolated jejunum; 3) decrease on the cat's arterial blood pressure; f) secretory effects on ...1978122174
crude extracts of hepatoprotective plants, solanum nigrum and cichorium intybus inhibit free radical-mediated dna damage.the presence of plant extracts of solanum nigrum and cichorium intybus in the reaction mixture containing calf thymus dna and free radical generating system protect dna against oxidative damage to its deoxyribose sugar moiety. the effect was dependent on the concentration of plant extracts. however, the effect of cichorium intybus was much pronounced as compared to the effect of solanum nigrum. these studies suggest that the observed hepatoprotective effect of these crude plant extracts may be d ...19957623482
glycoprotein isolated from solanum nigrum l. kills ht-29 cells through apoptosis.solanum nigrum l. (snl) has been used in folk medicine for its anti-inflammatory activity. we previously isolated glycoprotein from snl and observed that it decreased viable ht-29 cell numbers at a low concentration (60 microg/ml). this study investigated the apoptotic signal pathway triggered by glycoprotein isolated from snl in ht-29 cells. treatment of ht-29 cells with snl glycoprotein (60 microg/ml) for 4 hours resulted in a cytotoxic effect of more than 60%, compared with the control. to ex ...200516117614
[the hypotensive effect of solanum nigrum]. 19846235029
solanum nigrum: a model ecological expression system and its tools.plants respond to environmental stresses through a series of complicated phenotypic responses, which can be understood only with field studies because other organisms must be recruited for their function. if ecologists are to fully participate in the genomics revolution and if molecular biologists are to understand adaptive phenotypic responses, native plant ecological expression systems that offer both molecular tools and interesting natural histories are needed. here, we present solanum nigrum ...200415078438
glycoprotein isolated from solanum nigrum l. modulates the apoptotic-related signals in 12-o-tetradecanoylphorbol 13-acetate-stimulated mcf-7 cells.solanum nigrum l. (snl) has been used in folk medicine for its anti-inflammatory activity. we isolated only the snl glycoprotein from snl and found that it was cytotoxic at low concentration. with respect to cytotoxicity, we investigated whether purified snl glycoprotein is able to regulate protein kinase c (pkc) alpha activation and nuclear factor (nf)- kappab activities in 12-o-tetradecanoylphorbol 13-acetate (tpa)-induced tumor promotion, and whether it has an apoptosis-inducing effect in mcf ...200515857213
150 kda glycoprotein isolated from solanum nigrum linne enhances activities of detoxicant enzymes and lowers plasmic cholesterol in mouse.this study was carried out to investigate the modulation of detoxicant enzyme activity and plasma lipidemic levels by 150 kda glycoprotein isolated from solanum nigrum linne (snl), which has been used as a hepatoprotective and anticancer agent in folk medicine. our results in this study showed that snl glycoprotein has a band with 150 kda on the 10% sodium dodecyl sulfate polyacrylamide gel, and that it has a strong scavenging activity against lipid peroxyl radicals. we also evaluated the lipide ...200515749454
effects of solanum nigrum leaves water extract on the penetration and infectivity of schistosoma mansoni cercariae.a crude water extract of solanum nigrum leaves was used as a chemical attenuate to schistosoma mansoni cercariae prior to infection of swiss female mice. cercariae were exposed to 2.5, 5, 7.5 and 10 mg/l concentrations of the extract for 30 min. the effect on the ability of cercariae to penetrate mice skin, as well as, effect on schistosome worm burden after 8 weeks of infection were measured. the observed reduction of cercarial penetration was significant at 7.5 and 10 mg/l concentrations (p < ...200515880992
experimental and natural weed host-virus relations.weeds, as alternative hosts of plant viruses and nutrient plants of virus vectors play important role in virus ecology and epidemiology. the aim of our study was to discover new weed-virus relations. therefore some weed species were mechanically inoculated with 28 viruses (strains or isolates) maintained in our glasshouse. different weed species with and without visible symptoms were collected from agro-, water ecosystems and wastelands of hungary between 1997 and 2003. virus infections were eva ...200415759395
plastid transformants of tomato selected using mutations affecting ribosome structure.tomato plastid transformants were obtained using two vectors containing cloned plastid dna of either nicotiana tabacum or solanum nigrum and including point mutations conferring resistance to spectinomycin and streptomycin. transformants were recovered after peg-mediated direct dna uptake into protoplasts, followed by selection on spectinomycin-containing medium. sixteen lines contained the point mutation, as confirmed by mapping restriction enzyme sites. one line obtained with each vector was a ...200515965679
specificity in ecological interactions: attack from the same lepidopteran herbivore results in species-specific transcriptional responses in two solanaceous host plants.model systems have proven enormously useful in elucidating the biochemical function of plant genes. however their ecological function, having been sculpted by evolutionary forces specific to a species, may be less conserved across taxa. responses to wounding and herbivore attack differ among plant families and are known to be mediated by oxylipin, ethylene, and systemin-signaling networks. we analyzed transcriptional responses of two native solanaceous species to the attack of an herbivore whose ...200515980198
ethnomedicine of dharwad district in karnataka, india--plants used in oral health care.the present ethnomedicine survey covers the dharwad district of karnataka in southern india. it was revealed that 35 plants belonging to 26 families are being used to treat different types of oral ailments like toothache, plaque and caries, pyorrhea and aphthae. sixteen of these plants were new claims for the treatment of oral ailments not previously reported in the ethnomedicinal literature of india. basella alba, blepharis repens, capparis sepiaria, oxalis corniculata and ricinus communis are ...200415325728
begomovirus genetic diversity in the native plant reservoir solanum nigrum: evidence for the presence of a new virus species of recombinant nature.we examined the native plant host solanum nigrum as reservoir of genetic diversity of begomoviruses that cause the tomato yellow leaf curl disease (tylcd) emerging in southern spain. presence of isolates of all the species and strains found associated with tylcd in this area was demonstrated. mixed infections were common, which is a prerequisite for recombination to occur. in fact, presence of a novel recombinant begomovirus was demonstrated. analysis of an infectious clone showed that it result ...200616580040
glycine- and proline-rich glycoprotein isolated from solanum nigrum linne activates caspase-3 through cytochrome c in ht-29 cells.this study was carried out to investigate apoptotic effects of the glycoprotein (snl glycoprotein, 150 kda) isolated from solanum nigrum linne, which has been used as an anti-pyretic and anti-cancer agent in folk medicine. we found that the snl glycoprotein consists of carbohydrate (69.74%) and protein content (30.26%), which has >50% hydrophobic amino acids containing glycine and proline. ldh assay indicated that the snl glycoprotein has obvious cytotoxic and apoptotic effects (>50% cell death) ...200516077993
systemin in solanum nigrum. the tomato-homologous polypeptide does not mediate direct defense responses.we extend ryan's seminal work on the 18-amino acid polypeptide systemin in tomato's (solanum lycopersicum) systemic wound response to the closely related solanaceous species solanum nigrum. we compared wild-type plants to plants transformed with an inverted repeat prosystemin construct (irsys) to silence the expression of the endogenous s. nigrum prosystemin gene. in wild-type plants elicited with wounding + oral secretions from manduca sexta larvae, trypsin-proteinase inhibitors (tpis) accumula ...200617071641
molluscicidal and cercaricidal efficacy of acanthus mollis and its binary and tertiary combinations with solanum nigrum and iris pseudacorus against biomphalaria alexandrina.molluscicidial activity of leaves of acanthus mollis against biomphalaria alexandrina were evaluated. its petroleum ether extract (lc50 values = 6.92 mg/l) was more potent than solanum nigrum and iris pseudacorus extracts. a binary combination (1:1) of a. mollis and s. nigrum, as well as, a binary combination (1:1) of a. mollis and i. pseudacorus extracts showed additive effect on snails (24 hr lc50: 5.09 mg/l and 3.76 mg/l respecttively). a tertiary combination (1:1:1) of a. mollis, s. nigrum a ...200415587327
antinociceptive, anti-inflammatory and antipyretic effects of solanum nigrum chloroform extract in animal models.the present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of chloroform extract of solanum nigrum leaves using various animal models.200617077618
antiulcerogenic and ulcer healing effects of solanum nigrum (l.) on experimental ulcer models: possible mechanism for the inhibition of acid formation.solanum nigrum, an herbal plant which is recommended in ayurveda for the management of gastric ulcers. therefore, the purpose of the study was to investigate the antiulcer effect of solanum nigrum fruits extract (sne) on cold restraint stress (cru), indomethacin (ind), pyloric ligation (pl) and ethanol (etoh) induced gastric ulcer models and ulcer healing activity on acetic acid induced ulcer model in rats. the treatment with sne at higher dose significantly inhibited the gastric lesions induced ...200616202548
allelopathic effects of weeds extracts against seed germination of some plants.this study investigated the allelopathic effects of various weeds extracts on seed germination of 11 crop species. most of the weed extracts tested had inhibitory effects on seed germination of common bean, tomato, pepper, squash, onion, barley, wheat, and corn at different application rates as compared with the 10% acetone control. chickpea seed germination was inhibited by extracts of solanum nigrum l., chenopodium album l., and matricaria chamomilla l. (10%, 20% and 22.5%, respectively) at th ...200516161968
antitumor activity of crude polysaccharides isolated from solanum nigrum linne on u14 cervical carcinoma bearing mice.solanum nigrum linne (snl) has been used in traditional chinese medicine for centuries because of its diuretic and antipyretic effects. the present study examined the effect of the crude polysaccharides isolated from solanum nigrum linne (snl-p) on tumor growth. snl-p had a significant growth inhibition effect on cervical cancer (u14) of tumor-bearing mice. further analysis of the tumor inhibition mechanism indicated that the number of apoptotic tumor cells increased significantly, the expressio ...200717486683
zinc accumulation in solanum nigrum is enhanced by different arbuscular mycorrhizal fungi.solanum nigrum was found to proliferate in sediments with high levels of metal pollution. the effect of zn on plant growth and tissue metal accumulation was assessed. the response of the plant to the inoculation with four different isolates of arbuscular mycorrhizal fungi (amf) (glomus sp. beg140, glomus claroideum, glomus mosseae and glomus intraradices) was studied. while the isolates of amf did not have a significant (p<0.05) influence on mycorrhizal colonisation, increasing zn concentration ...200616650459
cancer-preventive peptide lunasin from solanum nigrum l. inhibits acetylation of core histones h3 and h4 and phosphorylation of retinoblastoma protein (rb).lunasin, a unique 43 amino acid, 4.8 kda cancer-chemopreventive peptide initially reported in soybean and now found in barley and wheat, has been shown to be cancer-chemopreventive in mammalian cells and in a skin cancer mouse model against oncogenes and chemical carcinogens. to identify bioactive components in traditional herbal medicines and in search for new sources of lunasin, we report here the properties of lunasin from solanum nigrum l. (snl), a plant indigenous to northeast asia. lunasin ...200718038993
steroidal saponins from solanum nigrum.six new steroidal saponins, solanigrosides c-h (2-7), and one known saponin, degalactotigonin (1), were isolated from the whole plant of solanum nigrum. their chemical structures were elucidated using spectroscopic analysis, chemical degradation, and derivatization. all seven compounds were tested for their cytotoxicity using four human tumor cell lines (hepg2, nci-h460, mcf-7, sf-268). only compound 1 was cytotoxic, with ic50 values of 0.25-4.49 microm.200616933867
behaviour of alpha-, beta-, gamma-, and delta-hexachlorocyclohexane in the soil-plant system of a contaminated site.the behaviour of the organochlorine pesticide hexachlorocyclohexane (hch) is investigated. the concentrations of alpha-, beta-, gamma-, and delta-hch isomers were measured in soils, rhizosphere and vegetation in a contaminated area in galicia (nw spain). the total concentration of hch in soils reached values close to 20,000 mgkg(-1). the plants analysed (avena sativa l., chenopodium spp., solanum nigrum l., cytisus striatus (hill) roth, and vicia sativa l.) accumulated hch, especially the beta-h ...200616824654
solanum nigrum produces nitric oxide via nuclear factor-kappab activation in mouse peritoneal macrophages.nitric oxide (no) is an antitumour molecule produced in activated macrophages and solanum nigrum is a plant used in oriental medicine to treat tumours. in this study using mouse peritoneal macrophages, we have examined the mechanism by which solanum nigrum regulates no production. when solanum nigrum was used in combination with 20 u/ml of recombinant interferon-gamma (rifn-gamma), there was a marked cooperative induction of no production. the increase in no synthesis was reflected as an increas ...200516030424
comparative anti-hyperglycemic potentials of medicinal plants.validation of the ethnobotanical use of the leaves of artemisia vulgaris linn. (compositae), eucalyptus tereticornis sm. (myrtaceae), solanum nigrum linn. (solanaceae), and vitex negundo linn. (verbenaceae); stems of nopalea cochinellifera (linn.) salm-dyck (cactaceae); roots of imperata cylindrica beauv. (gramineae); dried bark of syzygium cumini (linn.) skeels (myrtaceae) as anti-diabetic agents using the oral glucose tolerance test showed that only the bark of syzygium cumini and the leaves o ...200616253452
molecular, biochemical and structural characterization of osmotin-like protein from black nightshade (solanum nigrum).a full-length 910bp cdna encoding osmotin-like protein with an open reading frame of 744bp encoding a protein of 247 amino acids with a calculated molecular mass of 26.8kda was cloned from solanum nigrum (sniolp). phylogenetic analysis revealed the evolutionary conservation of this protein among diverse taxa. the genomic dna gel blot showed that sniolp belongs to a small multigene family and it showed organ-specific expression. time-course studies revealed that the expression of sniolp was upreg ...200716542753
herbicide-affected plant metabolism reduces virus has been previously shown that certain herbicides or plant extracts inhibited the viral infection. the goal of this study was to investigate the effect of obuda pepper virus (obpv) infection and herbicide or plant extract treatments on the photosynthetic processes of the host plants to get informations about the interactions of these factors. in capsicum annuum-obpv host-virus relations the virus infection slightly increased the activity of photosystem ii (psii), as it was supposed from fluor ...200617139793
salinity stress enhances production of solasodine in solanum nigrum l.various in vitro grown tissues (non-regenerative callus, regenerative callus and microshoot derived leaves) of solanum nigrum l. were cultured under salinity stress (0-150 mm nacl) for enhanced production of solasodine, a steroidal alkaloid and an alternative to diosgenin, which is used as a precursor for the commercial production of steroidal drugs. the role of plant growth regulators and various concentrations of nacl during in vitro production of solasodine was studied. the in vitro yield was ...200818175968
hela cells treated with phytoglycoprotein (150 kda) were killed by activation of caspase 3 via inhibitory activities of nf-kappab and ap-1.the solanum nigrum linne (snl) has been traditionally used as a herbal agent in folk medicine for various cancers in korea. we found that the snl glycoprotein consists of carbohydrate (69.74%) and protein content (30.26%), which has mainly the hydrophobic amino acids containing glycine and proline. with respect to its characters, we evaluated the apoptotic effects of glycoprotein isolated from snl in human cervical cancer cell. in the activity of the apoptotic related proteins [cytochrome c, cas ...200717192825
[changed ratios of some pigments of photosynthesis in nicotiana tabacum l. induced by exogenic dna].the technology of obtaining the tobacco plants possessing the hereditary changes in the photosynthesis pigments accumulation during development using exogenous dna has been elaborated. the plants possessing changes in proportion of chlorophylls content in the leave tissues, inherited elevated carotenoid content and altered proportion of carotene and xanthophylls, luteine and violaxanthine have been obtained by action of the salt-tolerant nightshade (solanum nigrum l.) dna and the dnas of pcamvne ...200617290784
[photosynthetic characteristics and coenological survey of lactuca serriola in its invaded area].lactuca serriola, a national class quarantine object, is a new invasive species in the coastal area of southeast china. the coenological survey showed that because of its big individual, l. serriola could easily form dominant population in its invaded area, and its main accompany species were conyza canadensis, c. bonarinisis, bidentis bipinnata, oenothera laciniata, ipomoea hederacea, setaria viridis, daucus carota, xanthium sibiricum, erigeron annuus, l. indica, humulus scandens, solanum nigru ...200617330472
antimicrobial evaluation of some medicinal plants for their anti-enteric potential against multi-drug resistant salmonella typhi.screening was done of some plants of importance in the ayurvedic system of traditional medicine used in india to treat enteric diseases. fifty four plant extracts (methanol and aqueous) were assayed for their activity against multi-drug resistant salmonella typhi. strong antibacterial activity was shown by the methanol extracts of aegle marmelos, salmalia malabarica, punica granatum, myristica fragrans, holarrhena antidysenterica, terminalia arjuna and triphal (mixture of emblica of fi cinalis, ...200415476301
application of manure and compost to contaminated soils and its effect on zinc accumulation by solanum nigrum inoculated with arbuscular mycorrhizal fungi.zn accumulation in solanum nigrum grown in naturally contaminated soil in the presence of different types of organic amendments was assessed. under the same conditions, the response of the plant to inoculation with two different isolates of arbuscular mycorrhizal fungi (amf) (glomus claroideum and glomus intraradices) was also evaluated. s. nigrum grown in the non-amended soil always presented higher zn accumulation in the tissues, with the addition of amendments inducing reductions of up to 80 ...200817507124
effect of sublethal concentration of solanum nigrum on transaminases and lactate dehydrogenase of biomphalria arabica, in saudi arabia.schistosomes have a complex lifecycle with freshwater intermediate host snails. the snail host represents the weakest point in the lifecycle of parasite. biomphalaria arabica is intermediate host for schistosoma mansoni in saudi arabia. in this work, aspartate and alanine aminotransferases (ast and alt) and lactate dehydrogenase (ldh) were measured in the tissue homogenate and haemolymph of b. arabica. besides, the effect of sublethal concentrations (lc25) of dry powdered solanum nigrum leaf was ...200717580567
[induction and in vitro culture of hairy roots of solanum nigrum l. var. pauciflorum liou and its solasodine production].by using genetic transformation of agrobacterium rhizogenes and liquid culture, induction and culture conditions for solanum nigrum l. var. pauciflorum liou hairy roots and its solasodine production and consumption changes of n resource and calcium in the medium during liquid culture were investigated. the results showed that hairy roots could be initiated from the cut edges of leaf explants 5 days after inoculation with the strain of a. rhizogenes atcc15834. the percentage of rooted leaf explan ...200818630597
new indicator plants for potato virus x.for over 2 years (2002-2004); a sever virus like disease on leaves in pisum sativum was observed from tehran in iran. the identity of which was established by the following host reactions and serological and molecular assays. collected samples were tested for the presence of the virus using the das-elisa (direct double antibody sandwich-elisa). leaf sap of each test samples was diluted 1:10 in elisa sample buffer. the samples reacted in elisa with antibody against potato virus (x)(pvx). the samp ...200617390890
edds and edta-enhanced zinc accumulation by solanum nigrum inoculated with arbuscular mycorrhizal fungi grown in contaminated soil.the effect of two different chelating agents [edta and edds (s,s-ethylenediaminedissucinic acid)] on zn tissue accumulation in solanum nigrum l. grown in a naturally contaminated soil was assessed. under those conditions, the response of the plant to the inoculation with two different isolates of arbuscular mycorrhizal fungi (amf)--glomus claroideum and glomus intraradices--was also studied. plants grown in the local contaminated soil (zn levels of 433mg kg(-1)) accumulated up to 1191mg kg(-1) o ...200817920101
aqueous extract of solanum nigrum inhibit growth of cervical carcinoma (u14) via modulating immune response of tumor bearing mice and inducing apoptosis of tumor explore the antitumor activity of aqueous extract of solanum nigrum (snl-ae) and its possible mechanism, we examined the effects of snl-ae on the tumor growth in vivo, the number of cd4+, cd8+ t lymphocyte subsets of peripheral blood in tumor-bearing mice by means of facscan flow cytometer, the expression of pcna in u14 cervical carcinoma section by means of immunohistochemistry sp method, the cell cycle of transplanted tumor by means of facscan flow cytometer and dna fragmentation by means o ...200818687388
inhibitory effect of solanum nigrum on thioacetamide-induced liver fibrosis in mice.solanum nigrum (solanaceae) has been used in traditional folk medicine for its hepatoprotective agent. the purpose of this study was to investigate the effects of solanum nigrum extract (sne) on thioacetamide (taa)-induced liver fibrosis in mice.200818606216
solanum nigrum grown in contaminated soil: effect of arbuscular mycorrhizal fungi on zinc accumulation and histolocalisation.zn tissue accumulation in solanum nigrum grown in a non-contaminated and a naturally contaminated zn matrix and the effect of inoculation with different arbuscular mycorrhizal fungi (amf) on metal uptake were assessed. s. nigrum grown in the contaminated soil always presented higher zn accumulation in the tissues, accumulating up to 1622 mg zn kg(-1). the presence of both glomus claroideum and glomus intraradices enhanced the uptake and accumulation of zn by s. nigrum (up to 83 and 49% higher zn ...200716905229
hepatoprotective effects of solanum nigrum linn extract against ccl(4)-induced oxidative damage in rats.solanum nigrum l. (sn) is an herbal plant that has been used as hepatoprotective and anti-inflammation agent in chinese medicine. in this study, the protective effects of water extract of sn (sne) against liver damage were evaluated in carbon tetrachloride (ccl4)-induced chronic hepatotoxicity in rats. sprague-dawley (sd) rats were orally fed with sne (0.2, 0.5, and 1.0 g kg(-1) bw) along with administration of ccl4 (20% ccl4/corn oil; 0.5 ml kg(-1) bw) for 6 weeks. the results showed that the t ...200818045581
study on the role of common weeds in survival of verticillium dahliae the causal agent of cotton wilt disease.this study was carried out to investigate the roles of common weeds in the survival of verticillium dahliae and the incidence of cotton wilt disease in moghan and neishabour area of iran during 2003-2005 cropping seasons. the design of the experiment was randomized complete blocks (rcb) with ten treatments (no. of weeds) and four replications (no. of cotton fields). populations of v. dahliae in the roots of weeds and their surrounding soil was determined every year and were compared in different ...200719090252
screening of korean medicinal plants for possible osteoclastogenesis effects in vitro.bone undergoes continuous remodeling through bone formation and resorption, and maintaining the balance for skeletal rigidity. bone resorption and loss are generally attributed to osteoclasts. differentiation of osteoclasts is regulated by receptor activator of nuclear factor nf-kb ligand (rankl), a member of tumor necrosis factor family. when the balance is disturbed, pathological bone abnormality ensues. through the screening of traditional korean medicinal plants, the effective molecules for ...200818850234
molluscicidal and antiparasitic activity of solanum nigrum villosum against galba truncatula infected or uninfected with fasciola hepatica.the present study was based on assessments of the molluscicidal and antiparasitic activities of solanum nigrum villosum. this plant has been collected in tozeur's traditional oases (south-western tunisia). molluscicidal activities of leaves, ripe fruit and unripe fruit extracts of s. n. villosum have been assessed in experimental and semi-field conditions on uninfected galba truncatula. antiparasitic activities have also been assessed on larval stages (rediae, intraredial germinal masses and cer ...200818462554
carcinogens and endemic squamous cancer of the oesophagus in transkei, south africa. environmental initiation is the dominant factor; tobacco or other carcinogens of low potency or concentration are sufficient for carcinogenesis in the predisposed mucosa.oesophageal cancer is common in africa, and is a major cause of death in transkei, south africa. the cause of this endemic disease has been debated for many decades. a continuing focus of research has been identification of a single potent carcinogen. i argue that endemic incidence of oesophageal cancer is associated with potent initiation, not with potent carcinogenesis. tobacco is a known oesophageal carcinogen, and there is very strong evidence that it is causally involved in a significant pr ...200717258402
potential of olive mill waste and compost as biobased pesticides against weeds, fungi, and nematodes.the phytotoxic and antimicrobial properties of olive mill wastes have been widely investigated and demonstrated over the past decade. however, their potential utilization as biodegradable pesticides against plant pathogens is still poorly understood. in this study, a series of laboratory bioassays was designed to test the inhibitory effects of sterile water extracts of two-phase olive mill waste (tpomw) and tpomw composts with different degrees of stabilization on several different plant pathoge ...200818471866
hatch and reproduction of globodera tabacum tabacum in response to tobacco, tomato, or black nightshade.the effects of broadleaf tobacco, tomato, and black nightshade on juvenile hatch and reproduction of globodera tabacum tabacum were determined in laboratory and greenhouse experiments. root exudates from nightshade stimulated greater egg hatch than those from either 'rutgers' tomato or '86-4' tobacco. hatch was greater at higher proportions of root exudates for all three plant species. root exudates from plants greater than 3 weeks old stimulated more hatch than younger plants. no regression rel ...199519277303
intraspecific morphological variation among populations of pratylenchus brachyurus and p. coffeae.three populations of pratylenchus coffeae and two of p. brachyurus, each originating from a single female, were maintained on citrus spp. or solanum nigrum l. for several years under greenhouse conditions. nematodes were extracted from roots, and adult female specimens were killed, fixed, and mounted in glycerine for microscopic study. variables measured were distance between vulva and anus and lengths of the stylet, posterior uterine sac, and tail. the mean data and coefficients of variability ...197819305830
antioxidant, antimicrobial and cytotoxic activities of selected medicinal plants from yemen.ninety crude extracts, including dichloromethane, methanol and aqueous extracts from 30 medicinal plants used in the yemeni ethnomedicine to treat common infections, were screened in vitro for antimicrobial activities against three gram-positive bacteria and two gram-negative bacteria, candida maltosa and five opportunistic human fungal pathogens (two yeasts, three hyphomycetes). most of the plants showed antibacterial activities. extracts from tamarindus indica flowers and ficus vasta fruits ha ...200717306942
the effect of a sublethal concentration of solanum nigrum on some antioxidants in biomphalaria arabica.schistosomisis is endemic in many rural areas of developing countries. the life cycle of schistosomes is complex with two hosts, an intermediate snail host and a definitive human host. biomphalaria arabica is the intermediate host for schistosoma mansoni in saudi arabia. one method of controlling the disease is to break the life cycle at the intermediate host snail stage using molluscicides. snails kill schistosomes by a mechanism involving production of reactive oxygen species. in this study ma ...201020503599
isolation and characterization of hydroxyproline-rich glycopeptide signals in black nightshade leaves.a gene encoding a preprohydroxyproline-rich systemin, snpreprohypsys, was identified from the leaves of black nightshade (solanum nigrum), which is a member of a small gene family of at least three genes that have orthologs in tobacco (nicotiana tabacum; ntpreprohypsys), tomato (solanum lycopersicum; slpreprohypsys), petunia (petunia hybrida; phpreprohypsys), potato (solanum tuberosum; phpreprohypsys), and sweet potato (ipomoea batatas; ibpreprohypsys). snpreprohypsys was induced by wounding and ...200919403725
effect of plant molluscicides on selected enzymes related to energy metabolism in biomphalaria arabica snails molluscan hosts to schistosoma mansoni in saudi arabia.schistosomiasis is one of the most important human parasitic diseases. one of the possible methods for the control is through the molluscan intermediate host of the parasite. biomphalaria arabica, molluscan hosts to schistosoma mansoni in saudi arabia were treated with sublethal concentrations (lc25) of dry powdered leaves solanum nigrum. effect of plant on ectonucleotidases (ntpdases) (adpase & atpase), sodium/potassium adenosine triphosphatase (na+/k+ atpase) and creatine kinase (ck) was trace ...201020503597
a dual fluorescent/maldi chip platform for analyzing enzymatic activity and for protein profiling.being able to rapidly and sensitively detect specific enzymatic products is important when screening biological samples for enzymatic activity. we present a simple method for assaying protease activity in the presence of protease inhibitors (pis) by measuring tryptic peptide accumulation on copolymer pmaldi target chips using a dual fluorescence/maldi-tof-ms read-out. the small platform of the chip accommodates microliter amounts of sample and allows for rapid protein digestion. fluorescamine la ...200919053144
expression in escherichia coli, purification, refolding and antifungal activity of an osmotin from solanum nigrum.abstract:200818334031
severe outbreak of tomato yellow leaf curl sardinia virus on pepper in southern italy.during summer and autumn 2008 a severe outbreak of pepper leaf curl disease (plcd) was observed in pepper crops under plastic tunnels in the ionic coast of basilicata region. its incidence reached, in some cases, values close to 50%. the beginning of infections was recorded along the perimeter of the tunnels, where it reached a percentage of almost 100%. the infection then progressively spread towards the central areas of the greenhouses. large populations of whiteflies, identificated as bemisia ...200920222578
optimized virus-induced gene silencing in solanum nigrum reveals the defensive function of leucine aminopeptidase against herbivores and the shortcomings of empty vector controls.virus-induced gene silencing (vigs) enables high-throughput analysis of gene function in plants but is not universally applicable and requires optimization for each species. here a vigs system is described for solanum nigrum, a wild relative of tomato and potato and a valuable model species for ecogenomics. the efficiency of the two most widely used tobacco rattle virus (trv) vectors to silence phytoene desaturase (pds) in s. nigrum was tested. additionally, the infiltration method and growth te ...200819086287
[experimental study of solanum nigrum on inhibiting angiogenesis in chick chorioallantoic membrane].to study the inhibitory effect of solanum nigrum on angiogenesis.200818536381
tomato yellow leaf curl viruses: ménage à trois between the virus complex, the plant and the whitefly vector.tomato yellow leaf curl disease (tylcd) is one of the most devastating viral diseases affecting tomato crops in tropical, subtropical and temperate regions of the world. here, we focus on the interactions through recombination between the different begomovirus species causing tylcd, provide an overview of the interactions with the cellular genes involved in viral replication, and highlight recent progress on the relationships between these viruses and their vector, the whitefly bemisia tabaci. t ...201020618703
improvement of phytoextraction and antioxidative defense in solanum nigrum l. under cadmium stress by application of cadmium-resistant strain and citric acid.remediation of plant-microorganism-chelates synergy has been proposed as an effective remediation method for enhancing the removal efficiency of heavy metal. manipulation of the antioxidative system increases plant tolerance, thereby potentially enhancing the uptake capacity to heavy metal. in this study, we investigated the possibility of improving the phytoextraction of cd and the antioxidative defense of solanum nigrum l. by application of a new isolated strain (paecilomyces lilacinus nh1) (p ...201020566243
anti-seizure activity of the aqueous leaf extract of solanum nigrum linn (solanaceae) in experimental animals.solanum nigrum is claimed in traditional medical practice, to be useful in the treatment of epilepsy in some parts of nigeria.200819357754
antinociceptive, anti-inflammatory and antipyretic effects of solanum nigrum aqueous extract in animal models.the present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of the aqueous extract of solanum nigrum leaves using various animal models. the extract, at concentrations of 10, 50 and 100%, was prepared by soaking (1:20; w/v) air-dried powdered leaves (20 g) in distilled water (dh2o) for 72 h. the extract solutions were administered subcutaneously in mice/rats 30 min prior to the tests. the extract exhibited significant (p < 0.05) antinociceptive ac ...200919455262
bioremediation of heavy metals by growing hyperaccumulaor endophytic bacterium bacillus sp. l14.heavy metal bioremediation by a multi-metal resistant endophytic bacteria l14 (eb l14) isolated from the cadmium hyperaccumulator solanum nigrum l. was characterized for its potential application in metal treatment. 16s rdna analysis revealed that this endophyte belonged to bacillus sp. the hormesis of eb l14 were observed in presence of divalent heavy metals (cu (ii), cd (ii) and pb (ii)) at a relatively lower concentration (10mg/l). such hormesis was the side effect of abnormal activities incr ...201020637605
ethnopharmacological survey of wild medicinal plants in showbak, jordan.two main research questions are framing this investigation: (1) the main taxa of the medicinal importance value altered the showbak forest stand and species composition? (2) the most safe species and what are the toxic ones (unsafe). these two research questions are the vital ones to draw a clear image about the wild medicinal plants of this investigated area of showbak region in jordan. 79 wild medicinal plant species were investigated in this study which are used in traditional medication for ...200919429338
three years survey of tomato yellow leaf curl sardinia virus reservoir weed hosts in southern italy.during the period from august 2004 to june 2006 a serious tomato yellow leaf curl epidemic caused by both tomato yellow leaf curl sardinia virus (tylcsv) and tomato yellow leaf curl virus (tylcs) was observed in protected tomato crops in castrovillari, calabria region, in a group of greenhouses where tomato is grown hydroponically. a three years survey for reservoir weed hosts of these viruses was performed during summer period in order to identify where the viruses persist during the host-free ...200718396845
antitumor effects of total alkaloids isolated from solanum nigrum in vitro and in vivo.this study demonstrated that the total alkaloids isolated from the traditional chinese medicinal herb solanum nigrum linne (snl-a) inhibited the growth of human cervical cancer hela cells in culture medium with much lower toxicity to human normal lymphocytes. by means of he staining and tunel assay, our results further revealed that snl-a induced cell death by apoptosis. an immunohistochemical assay showed down-regulation of the bcl-2 and p53 genes and no obvious change of bax gene in the snl-a ...200818717490
salt affects plant cd-stress responses by modulating growth and cd accumulation.cadmium contamination is a serious environmental problem for modern agriculture and human health. salinity affects plant growth and development, and interactions between salt and cadmium have been reported. however, the molecular mechanisms of salinity-cadmium interactions are not fully understood. here, we show that a low concentration of salt alleviates cd-induced growth inhibition and increases cd accumulation in arabidopsis thaliana. supplementation with low concentrations of salt reduced th ...201019943170
evaluation of indigenous plant extracts against larvae of culex quinquefasciatus say (diptera: culicidae).this study investigates the larvicidal potential of indigenous plant extracts from commonly used medicinal herbs as an environmentally safe measure to control the filarial vector, culex quinquefasciatus say (diptera: culicidae). the early fourth-instar larvae of c. quinquefasciatus, reared in the laboratory, were used for larvicidal assay with water, hot water, acetone, chloroform, and methanol leaf, stem-bark, and flower extracts of acacia arabica willd. sans, cedrus deodara roxb, hibiscus rosa ...200918975001
solanum nigrum l. extract inhibits 2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of glutathione s-transferase and antioxidant enzymes.solanum nigrum l. (sn) is a widespread plant and is regarded as a common relish in the east and the south of taiwan. our previous study has found that sn water extract (snwe) alleviated carbon tetrachloride-induced liver damage in rats. however, the effects of snwe on chemical-induced hepatic injury and hepatocarcinogenesis remain unclear. therefore, this study aims to investigate the effects of snwe on hepatic injury and hepatocarcinogenesis by using 2-acetylaminofluorene (aaf) and aaf/nano(2) ...200919702266
phytoglycoprotein (150 kda) isolated from solanum nigrum linne has a preventive effect on dextran sodium sulfate-induced colitis in a/j mouse.the purpose of this study was to investigate the preventive effect of glycoprotein (snl glycoprotein, 150 kda) isolated from solanum nigrum linne fruits on dextran sulfate sodium (dss, 3%)-induced colitis in a/j mice. to determine the physiological change by snl glycoprotein, we first evaluated nitric oxide production, lactate dehydrogenase release and thiobarbituric acid reactive substances formation in the mice serum. after that, we tested the activity of inflammation-related signals such as t ...200918988204
down-regulation of systemin after herbivory is associated with increased root allocation and competitive ability in solanum nigrum.after simulated herbivory, inflicted by a treatment involving wounding and the application of manduca sexta oral secretions (os) to mechanical wounds (os-elicitation), transcripts of the systemin-precursor, prosystemin, are down-regulated in black nightshade (solanum nigrum). since s. nigrum silenced in prosystemin expression (irsys) has unaltered herbivore resistance but produced more above-ground biomass and berries than did wild-type (wt) competitors in a pilot experiment, we examine the hypo ...200919037662
isolation and characterization of endophytic bacterium lre07 from cadmium hyperaccumulator solanum nigrum l. and its potential for remediation.valuable endophytic strains facilitating plants growth and detoxification of heavy metals are required because the application of plant-endophyte symbiotic system is a promising potential technique to improve efficiency of phytoremediation. in this study, endophytic bacterium lre07 was isolated from cadmium hyperaccumulator solanum nigrum l. it was identified as serratia sp. by 16s rrna sequence analysis. the endophytic bacterium lre07 was resistant to the toxic effects of heavy metals, solubili ...201020953602
small quantities of carotenoid-rich tropical green leafy vegetables indigenous to africa maintain vitamin a status in mongolian gerbils ( meriones unguiculatus).leafy vegetables are important sources of provitamin a carotenoids. information on their ability to provide vitamin a is often misleading because of the methodology used to assess bioefficacy. mongolian gerbils were used to evaluate the bioefficacy of provitamin a carotenoids in tropical leafy vegetables (i.e. solanum nigrum, moringa oleifera, vernonia calvoana and hibiscus cannabinus) that are indigenous to africa. gerbils (n 67) were vitamin a-depleted for 5 weeks. after a baseline kill (n 7), ...201020412609
antioxidant and antihyperlipidemic effect of solanum nigrum fruit extract on the experimental model against chronic ethanol toxicity.the possible protective effect of solanum nigrum fruit extract (snfet) was investigated for its antioxidant and antihyperlipidemic activity against ethanol-induced toxicity in rats. the experimental animals were intoxicated with 20% ethanol (7.9 g/kg/day) for 30 days via gastric intubation. snfet was administered at the dose of 250 mg/kg body weight along with the daily dose of ethanol for 30 days. from the result it was observed that ethanol-induced rats showed a significant elevation in the le ...201020548935
in vivo antimalarial activities of glycoalkaloids isolated from solanaceae plants.malaria is one of the most common and serious protozoan tropical diseases. multi-drug resistance remains pervasive, necessitating the continuous development of new antimalarial agents.201020731554
solanum nigrum linn. water extract inhibits metastasis in mouse melanoma cells in vitro and in vivo.metastatic melanoma is an aggressive skin cancer notoriously resistant to current cancer therapies. thus, new treatment strategies are urgently needed. solanum nigrum linn., commonly used in oriental medicine, has showed antineoplastic activity in human cancer cell lines. the aim of this study was to evaluate the inhibitive effect of s. nigrum linn. water extract (snwe) on melanoma metastasis and dissect the underlying mechanisms of snwe actions. b16-f1 cells were analyzed for migrating and inva ...201021028816
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