| taste and olfaction in human obesity. | earlier studies have shown differences between normal weight and obese humans in responsivity to external and internal stimuli. this study shows that normal weight and obese subjects do not differ in hedonic response to sucrose (taste) and benzaldehyde (odor). however, a perceptual typing of individuals based upon hedonic response is possible for both gustatory and olfactory processes. ratings of pleasantness for the sweet taste of sucrose appear to generalize to the food-related odor of bitter ... | 1977 | 607246 |
| novel scheme for biosynthesis of aryl metabolites from l-phenylalanine in the fungus bjerkandera adusta. | aryl metabolite biosynthesis was studied in the white rot fungus bjerkandera adusta cultivated in a liquid medium supplemented with l-phenylalanine. aromatic compounds were analyzed by gas chromatography-mass spectrometry following addition of labelled precursors ((14)c- and (13)c-labelled l-phenylalanine), which did not interfere with fungal metabolism. the major aromatic compounds identified were benzyl alcohol, benzaldehyde (bitter almond aroma), and benzoic acid. hydroxy- and methoxybenzylic ... | 2000 | 10742235 |
| shifting the biotransformation pathways of l-phenylalanine into benzaldehyde by trametes suaveolens cbs 334.85 using hp20 resin. | the biotransformation of l-phenylalanine into benzaldehyde (bitter almond aroma) was studied in the strain trametes suaveolens cbs 334.85. | 2001 | 11298938 |
| amygdalin suppresses lipopolysaccharide-induced expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse bv2 microglial cells. | amygdalin (d-mandelonitrile-beta-d-gentiobioside) is a cynogenic compound found in sweet and bitter almonds, persicae semen and armeniacae semen. amygdalin has been used for the treatment of cancers and for the relief of the pain. we made an aqueous extraction of amygdalin from armeniacae semen. in this study, the effect of amygdalin on the lipopolysaccharide (lps)-induced inflammation was investigated. | 2007 | 17359643 |
| determination of some aldehydes by using solid-phase microextraction and high-performance liquid chromatography with uv detection. | a new approach has been developed for the extraction and determination of aldehydes such as veratraldehyde, m-nitrobenzaldehyde, cinnamaldehyde, benzaldehyde, and p-chlorobenzaldehyde by using solid-phase microextraction (spme) and high-performance liquid chromatography with uv detection (hplc/uv). the method involves adsorption of the aldehydes on polydimethylsiloxane/divinylbenzene-coated fiber, followed by desorption in the desorption chamber of the spme-hplc interface, using acetonitrile-wat ... | 2007 | 18193749 |
| [effect of processing on metabolism of amygdalin from bitter almond in rat]. | to study the influence of processing on metabolism of the main component of bitter almond-amygdalin in rat. | 2010 | 21246818 |
| ruta montana l. leaf essential oil and extracts: characterization of bioactive compounds and suppression of crown gall disease. | the aims of this study were to assess the antimicrobial efficacy of the leaf essential oil and the leaf extracts of r. montana against botrytis cinerea, fusarium oxysporum, verticillium dahliae, aspergillus oryzae and fusarium solani. the oil (1.000 µg/disk) and the extracts (1.500 µg/disk) revealed a remarkable antifungal effect against the tested plant pathogenic fungi with a radial growth inhibition percentage of 40.0-80.0 % and 5.0-58.0 %, respectively along with their respective mic values ... | 2015 | 26417353 |
| plant compounds enhance the assay sensitivity for detection of active bacillus cereus toxin. | bacillus cereus is an important food pathogen, producing emetic and diarrheal syndromes, the latter mediated by enterotoxins. the ability to sensitively trace and identify this active toxin is important for food safety. this study evaluated a nonradioactive, sensitive, in vitro cell-based assay, based on b. cereus toxin inhibition of green fluorescent protein (gfp) synthesis in transduced monkey kidney vero cells, combined with plant extracts or plant compounds that reduce viable count of b. cer ... | 2015 | 25767986 |
| anti-dermatophyte efficacy and environmental safety of some essential oils commercial and in vitro extracted pure and combined against four keratinophilic pathogenic fungi. | establish new biocontrol practices with low persistence in the environment against dermatophyte causing mycosis. | 2015 | 25953414 |
| extraction, chemical composition, and antifungal activity of essential oil of bitter almond. | the essential oil from the powder residual of dried bitter almond, a novel and environmentally-friendly fungicide, was successfully extracted in a 0.7% yield by hydro-distillation under optimized conditions. the chemical composition of bitter almond essential oil (baeo) was analyzed by gas chromatography-mass spectrometry (gc-ms). twenty-one different components representing 99.90% of the total essential oil were identified, of which benzaldehyde (62.52%), benzoic acid (14.80%), and hexadecane ( ... | 2016 | 27589723 |
| preparative separation of axifolin-3-glucoside, hyperoside and amygdalin from plant extracts by high-speed countercurrent chromatography. | high-speed countercurrent chromatography (hsccc) was successfully used to isolate three bioactive compounds, i.e., amygdalin from bitter almond and taxifolin-3-glucoside and quercetin-3-galactoside (hyperoside) from water extract of agrimonia pilosa ledeb, respectively. from 1 g of the crude extract 65 mg of amygdalin was isolated at 97% purity using a two-phase solvent system composed of ethyl acetate-n-butanol-water (5:2:5, v/v) by preparative hsccc. from a 400 mg amount of crude extract of ag ... | 2009 | 20046896 |
| rapid and sensitive ultrasonic-assisted derivatisation microextraction (udme) technique for bitter taste-free amino acids (faa) study by hplc-fld. | amino acids, as the main contributors to taste, are usually found in relatively high levels in bitter foods. in this work, we focused on seeking a rapid, sensitive and simple method to determine faa for large batches of micro-samples and to explore the relationship between faa and bitterness. overall condition optimisation indicated that the new udme technique offered higher derivatisation yields and extraction efficiencies than traditional methods. only 35min was needed in the whole operation p ... | 2014 | 24054218 |
| herbivore-induced volatiles: the emission of acyclic homoterpenes from leaves of phaseolus lunatus and zea mays can be triggered by a beta-glucosidase and jasmonic acid. | the treatment of healthy, undamaged plants of the lima bean phaseolus lunatus with solutions of a beta-glucosidase from bitter almonds (at 5 u.ml-1) through the petiole results in an enhanced emission of volatiles to the environment. the compounds are identical with those emitted in response to infestation with the red spotted spider mite tetranychus urticae. dominant products are the two acyclic homoterpenes 4,8-dimethyl-1,3e,7- dimethylnonatriene (homoterpene i) and 4,8,12-trimethyl-1,3e,7e,11 ... | 1994 | 7925964 |
| study of the volatile compounds and odor-active compounds of dry-cured iberian ham extracted by spme. | the volatile compounds and the most odor-active compounds of dry-cured iberian ham were investigated by extracting them using a solid phase microextraction technique with a 2 cm carboxen/pdms/dvb fiber. the detection frequency method was applied to estimate the potential contribution of each compound to the odor of hams. twenty-one volatile compounds were tentatively identified for the first time in dry-cured ham by gas chromatography-mass spectrometry, and eight in dry-cured iberian ham. gas ch ... | 0 | 23685564 |
| comparative genomics analysis in prunoideae to identify biologically relevant polymorphisms. | prunus is an economically important genus with a wide range of physiological and biological variability. using the peach genome as a reference, sequencing reads from four almond accessions and one sweet cherry cultivar were used for comparative analysis of these three prunus species. reference mapping enabled the identification of many biological relevant polymorphisms within the individuals. examining the depth of the polymorphisms and the overall scaffold coverage, we identified many potential ... | 2013 | 23763653 |
| a new approach for identification of medicinal almonds by fourier transform infrared spectroscopy and systematic clustering of characteristic peaks. | medicinal almonds have been used for over 2 000 years and its clinical efficacy includes relieving cough and asthma. the domestic market in china is flooded with different kinds of dried almonds, such as bitter almond (armeniacae semen amarum, aas), sweet almond (armeniacae semen dulce, ads), salted almond (armeniacae semen salsa, ass), and their sulfur-fumigating products (armeniacae semen sulphur fumabat, asfs). wide varieties of almonds may lead to uncertain efficacy, aberrant quality, and ev ... | 2017 | 28991532 |
| fast and robust discrimination of almonds (prunus amygdalus) with respect to their bitterness by using near infrared and partial least squares-discriminant analysis. | in this study, near-infrared spectroscopy (nir) coupled to chemometrics is used to develop a fast, simple, non-destructive and robust method for discriminating sweet and bitter almonds (prunus amygdalus) by the in situ measurement of the kernel surface without any sample pre-treatment. principal component analysis (pca) and partial least-squares discriminant analysis (pls-da) models were built to discriminate both types of almonds, obtaining high levels of sensitivity and specificity for both cl ... | 2014 | 24491694 |
| quantification of amygdalin in nonbitter, semibitter, and bitter almonds (prunus dulcis) by uhplc-(esi)qqq ms/ms. | amygdalin is a cynaogenic diglucoside responsible for the bitterness of almonds. almonds display three flavor phenotypes, nonbitter, semibitter, and bitter. herein, the amygdalin content of 20 varieties of nonbitter, semibitter, and bitter almonds from four primary growing regions of california was determined using solid-phase extraction and ultrahigh-pressure liquid chromatography electrospray triple-quadrupole mass spectrometry (uhplc-(esi)qqq ms/ms). the detection limit for this method is ≤ 0 ... | 2013 | 23862656 |
| cyanide and amygdalin as indicators of the presence of bitter almonds in imported raw almonds. | consumer complaints received by the u.s. food and drug administration in august 2010 about raw organic almonds tasting "bitter" opened an investigation into the presence of bitter almonds in the imported product. bitter almonds (prunus amygdalus) contain the cyanogenic glucoside amygdalin, which hydrolyzes to produce cyanide. ultraviolet-visible spectrophotometry was used to detect and quantitate cyanide, and liquid chromatography-mass spectrometry was utilized to detect amygdalin in the submitt ... | 2012 | 22564183 |
| prunasin hydrolases during fruit development in sweet and bitter almonds. | amygdalin is a cyanogenic diglucoside and constitutes the bitter component in bitter almond (prunus dulcis). amygdalin concentration increases in the course of fruit formation. the monoglucoside prunasin is the precursor of amygdalin. prunasin may be degraded to hydrogen cyanide, glucose, and benzaldehyde by the action of the β-glucosidase prunasin hydrolase (ph) and mandelonitirile lyase or be glucosylated to form amygdalin. the tissue and cellular localization of phs was determined during frui ... | 2012 | 22353576 |
| assignment of sweet almond beta-glucosidase as a family 1 glycosidase and identification of its active site nucleophile. | sweet almond beta-glucosidase is a well studied glycosidase, having been subjected to numerous kinetic analyses and inhibition studies. however, it is not known to which glycosidase family it belongs, nor is the identity of the active site nucleophile known with certainty. it can be inactivated using the specific, mechanism-based enzyme inactivator 2-deoxy-2-fluoro-beta-d-glucopyranosyl fluoride, which functions by forming a stable 2-deoxy-2-fluoro-alpha-d-glucopyranosyl-enzyme intermediate. the ... | 1997 | 9312086 |
| pattern of the cyanide-potential in developing fruits : implications for plants accumulating cyanogenic monoglucosides (phaseolus lunatus) or cyanogenic diglucosides in their seeds (linum usitatissimum, prunus amygdalus). | the absolute cyanide content of developing fruits was determined in costa rican wild lima beans (phaseolus lunatus), oil flax (linum usitatissimum), and bitter almonds (prunus amygdalus). the cyanide potential (hcn-p) of the lima bean and the almond fruit began to increase shortly after anthesis and then stopped before fruit maturity. in contrast, the flax inflorescence had a higher hcn-p in absolute terms than the mature flax fruit. at all times of its development the bean fruit contained the m ... | 1990 | 16667698 |
| [lethal poisoning with hydrocyanic acid after ingestion of bitter almonds (prunus amygdalus)]. | | 1972 | 4334843 |
| studies on the biosynthesis of amygdalin, the cyanogenic glycoside of bitter almonds (prunus amygdalus stokes). | | 1967 | 4228204 |
| [on the knowledge of cyanhydrin synthesis. ii. purification and properties of hydroxynitrilase from bitter almonds (prunus communis stokes)]. | | 1963 | 13970146 |
| amygdalin, from apricot kernels, induces apoptosis and causes cell cycle arrest in cancer cells: an updated review. | amygdalin is a cyanogenic glycoside which is described as a naturally occurring anti-cancer agent. in 1830s, french chemists robiquet and boutron-charlard isolated amygdalin from bitter almonds. apoptosis is an important mechanism in cancer treatment by amygdalin. amygdalin can probably stimulate apoptotic process in cancerous cells by increasing activity of bax (pro-apoptotic protein) and caspase-3 and decreasing expression of bcl-2 (anti-apoptotic protein). amygdalin promotes arrest of cell cy ... | 2018 | 29308747 |
| [medication rules of famous veteran traditional chinese medicine doctor in treatment of chronic bronchitis based on implicit structure model]. | to explore the medication rules of famous veteran traditional chinese medicine (tcm) doctors in treatment of chronic bronchitis, a structured medical record database for famous veteran tcm doctors in modern clinical books was established. first, lantern 3.1.2(kongmin light) implicit structure analysis software was used to build an implicit structure model and make an implicit interpretation. then, sas 9.1 was adopted to mine herb-herb, herb-symptom and herb-syndrome association rules. through th ... | 2017 | 29071870 |
| identification and analysis of amygdalin, neoamygdalin and amygdalin amide in different processed bitter almonds by hplc-esi-ms/ms and hplc-dad. | processing is a traditional pharmacy technology based on traditional chinese medicine theory. the traditional chinese medicine (tcm) ingredients should be processed before being used as a medicine. processed bitter almonds are widely used in the clinic in tcm for the treatment of cough and asthma. in this work the amygdalin profile of three producing areas in china was determined, with respect to three differently processed bitter almond products: raw, stir-fried and scalded. identification of t ... | 2017 | 28867779 |
| a novel dual-channel chemosensor for cn- using asymmetric double-azine derivatives in aqueous media and its application in bitter almond. | in this paper, we have designed and synthesized a novel sensor l1 based on asymmetric double-azine derivatives, which showed both "naked eye" recognition and fluorescence responses for cn- in dmso/h2o (v/v=4:1, ph=7.20) solution. this simple sensor l1 could distinguish cn- from coexisting anions via the way of deprotonation and sensing mechanism of intramolecular charge transfer (ict), and the minimum detection limit on fluorescence response of the sensor l1 towards cn- was down to 9.47×10-7m. m ... | 2017 | 28351819 |
| efficient salt-aided aqueous extraction of bitter almond oil. | salt-aided aqueous extraction (saae) is an inexpensive and environmentally friendly method of oil extraction that is influenced by many factors. in the present study, we investigated the effect of saae on bitter almond oil yield. | 2017 | 28150418 |
| application of the prunus spp. cyanide seed defense system onto wheat: reduced insect feeding and field growth tests. | many crops are ill-protected against insect pests during storage. to protect cereal grains from herbivores during storage, pesticides are often applied. while pesticides have an undoubtable functionality, increasing concerns are arising about their application. in the present study, we investigated a bioinspired cyanogenic grain coating with amygdalin as cyanogenic precursor mimicking the feeding-triggered release of hydrogen cyanide (hcn) found for example in bitter almonds. the multilayer coat ... | 2016 | 27119432 |
| extracorporeal membrane oxygenation (ecmo) for severe toxicological exposures: review of the toxicology investigators consortium (toxic). | although there have been many developments related to specific strategies for treating patients after poisoning exposures, the mainstay of therapy remains symptomatic and supportive care. one of the most aggressive supportive modalities is extracorporeal membrane oxygenation (ecmo). our goal was to describe the use of ecmo for toxicological exposures reported to the american college of medical toxicology (acmt) toxicology investigators consortium (toxic). we performed a retrospective review of t ... | 2016 | 26013746 |
| stretch marks during pregnancy: a review of topical prevention. | striae gravidarum (sg), or stretch marks developing during pregnancy, affect up to 90% of women. while not medically dangerous, sg can be disfiguring, causing emotional and psychological distress. however, studies specifically addressing the prevention of sg, especially during pregnancy, are sparse. furthermore, the molecular pathogenesis of sg is unclear and may differ from that of striae from other causes. considering these factors, we review topical modalities that have been used specifically ... | 2015 | 25255817 |
| [rat intestinal absorption trait of peimine and peiminine in thunberg fritillary bulb extract]. | to study the in situ intestinal absorption kinetics and compatibility influence of peimine and peiminine in rats, the absorption of peimine and peiminine in small intestine (duodenum, jejunum and ileum) and colon of rats was investigated using in situ single-pass perfusion method and the drug content was measured by hplc-elsd. perfusion rate, ph, concentration of drug, gender and bile duct ligation can significantly affect the absorption of peimine and peiminine, the ka, and papp values in the c ... | 2013 | 24689243 |
| [study on the determination of trace elements in bitter almond by inductively coupled plasma mass spectrometry]. | samples of bitter almond were digested by microwave digestion, and trace elements amounts of b, na, mg, al, p, k, ca, ti, v, cr, mn, fe, co, ni, cu, zn, as, se, rb, sr, mo, cd, ba and pb in sample solutions were determined by inductively coupled plasma mass spectrometry (icp-ms). hno3 + h2o2 was used to achieve the complete decomposition of the organic matrix in a closed-vessel microwave oven. the working parameters of the instrument were optimized. the result showed that the relative standard d ... | 2013 | 23905350 |
| the effect of bitter almond oil and massaging on striae gravidarum in primiparaous women. | this study aims to identify the effect of applying bitter almond oil with and without massage on preventing striae gravidarum during pregnancy. | 2012 | 22594386 |
| possible involvement of polyphenols and polyamines in salt tolerance of almond rootstocks. | leaf physiological and biochemical adaptive strategies and more particularly the possible involvement of polyamines and polyphenols in salt stress tolerance were investigated. three almond rootstocks (gn15, gf677 and bitter almond) were subjected to 0, 25, 50 and 75 mm nacl for 30 days. the dry mass of leaves, stems and roots decreased with increasing salt concentration in the irrigation solution regardless of genotype. photosynthetic assimilation rate decreased in the three almond rootstocks, b ... | 2011 | 22000055 |
| in-depth proteomic analysis of non-alcoholic beverages with peptide ligand libraries. i: almond milk and orgeat syrup. | combinatorial peptide ligand libraries, both commercial and home-made, have been adopted to investigate the proteome of non-alcoholic beverages, in order to assess their genuineness and detect also trace proteins, in search of potential allergens. two such beverages have been studied: almond milk and orgeat syrup. in the first product we have been able to identify 132 unique protein species, the deepest investigation so far of the almond proteome. in the second beverage, a handful of proteins (j ... | 2011 | 21440098 |
| an unusual cause of severe lactic acidosis: cyanide poisoning after bitter almond ingestion. | | 2011 | 20845029 |
| child cyanide poisoning after ingestion of bitter almonds. | | 2010 | 20560788 |
| an uncommon case of a suicide with inhalation of hydrogen cyanide. | an uncommon suicide by oral ingestion of potassium cyanide salts and contemporaneous inhalation of hydrogen cyanide is presented. a 48-year-old tradesman was found dead sitting in his car. a penetrating odor of bitter almonds was noticed when opening the doors. a camping stove and a cooking pot containing large amounts of dark blue crystals were found in the footwell of the car. white powder adhered to his fingers and to the area around the mouth. furthermore bottles containing potassium ferrocy ... | 2011 | 20541881 |
| model studies on the oxygen-induced formation of benzaldehyde from phenylacetaldehyde using pyrolysis gc-ms and ftir. | benzaldehyde, a potent aroma chemical of bitter almond, can also be formed thermally from phenylalanine and may contribute to the formation of off-aroma. to identify the precursors involved in its generation during maillard reaction, various model systems containing phenylalanine, phenylpyruvic acid, phenethylamine, or phenylacetaldehyde were studied in the presence and absence of moisture using oxidative and nonoxidative py-gc-ms. analysis of the data indicated that phenylacetaldehyde, the stre ... | 2008 | 18954073 |
| levels of inorganic constituents in raw nuts and seeds on the swedish market. | the levels of approximately 70 elements were determined in different culinary nuts (hazelnuts, walnuts, almonds, bitter almonds, pecans, cashews, brazil nuts, pistachios, pine nuts, peanuts and coconuts) and seeds (pumpkin and sunflower) available on the swedish market. the study was limited to raw, virtually unprocessed nuts and seeds (both shelled and unshelled) excluding mixed, roasted or salted products. in total, 44 products from different suppliers were analyzed, with the number of samples ... | 2008 | 18155749 |
| a structure-odour relationship study using eva descriptors and hierarchical clustering. | structure-odour relationship analyses using hierarchical clustering were carried out on a diverse dataset of 47 molecules. these molecules were divided into seven odour categories: ambergris, bitter almond, camphoraceous, rose, jasmine, muguet, and musk. the alignment-independent descriptor eva (eigenvalue) was used as the molecular descriptor. the results were compared with those of another kind of descriptor, the unity 2d fingerprint. the dendrograms obtained with these descriptors were compar ... | 2004 | 15534702 |
| suicide by cyanide: 17 deaths. | we reviewed 17 intentional ingestions of cyanide that occurred in new york city over a ten-year interval. the toxicologic and postmortem findings were reviewed. certain occupations and nationalities of the decedents predominated among this group of suicides. scientists, jewelers. and metal workers were common occupations among the decedents. in addition, 8 of 17 fatalities were west indian/caribbean island and south american decedents, including three decedents from guyana. fourteen of the 17 fa ... | 2004 | 15317203 |
| a method for the calculation of odor character from molecular structure. | the relationship between molecular structure and odor character is one of the most complex structure-activity problems in biology. despite over a century of effort, it remains unsolved, and synthesis of new odorants still proceeds largely by trial and error. in previous work, i have argued that the reason for this failure lies in a mistaken assumption, namely that molecular shape determines odor character. instead, i have taken up and extended an old idea (dyson, 1938) according to which vertebr ... | 2002 | 12183125 |
| cyanide poisoning, 2 cases report and treatment review. | two patients, a 4-year-old girl and her brother 1 1/2 year-old, with cyanide poisoning are reported. they vomited and became comatose 9 hours after ingestion of boiled cassava. at a community hospital, they were intubated and given ventilatory support. the girl was transferred to ramathibodi intensive care unit. at 19 hours after ingestion, sodium nitrite and sodium thiosulfate were given as well as other supportive treatment. she recovered with normal breathing on the next day. the boy was refe ... | 1999 | 10730537 |
| activation analyses of authenticated hairs of napoleon bonaparte confirm arsenic poisoning. | in 1960, activation analyses at the harwell nuclear research laboratory of the university of glascow, london of authenticated hairs of napoleon bonaparte taken immediately after his death confirmed napoleon's chronic arsenic poisoning on the island of st. helena. timeline correlation of his clinical symptomatology of the preceding 4 months, as reported in the written diaries of his exiled companions, further supports the effect of fluctuating, elevated toxic levels of arsenic on his health. inde ... | 1999 | 10624934 |
| enhanced benzaldehyde formation by a monokaryotic strain of pycnoporus cinnabarinus using a selective solid adsorbent in the culture medium. | a monokaryotic strain of the white-rot fungus pycnoporus cinnabarinus was shown to produce, in a 2-l bioreactor culture, 100 mg.l-1 benzaldehyde (bitter almond aroma) from l-phenylalanine with a productivity of 33 mg.l-1.day-1. the addition of hp20 resin, a styrene divinylbenzene copolymer highly selective for benzaldehyde, enabled an eightfold increase in the production of benzaldehyde and a twofold increase in productivity. in the presence of hp20 resin, the production of 790 mg.l-1 benzaldehy ... | 1999 | 10528397 |
| optimization of the enzymatic synthesis of butyl glucoside using response surface methodology | enzymatic synthesis of butyl glucoside by beta-glucosidase from bitter almonds was optimized using response surface methodology (rsm). empirical models were developed to describe relationships between the operating variables (temperature, water/butanol volume ratio, glucose concentration, enzyme concentration) and responses (butyl glucoside concentration, conversion yield). statistical analysis indicated that the four factors had significant effects on the butyl glucoside synthesis. optimal conc ... | 1998 | 9841649 |
| biotechnological production of flavours and fragrances. | the biotechnological generation of natural aroma compounds is rapidly expanding. aroma chemicals, such as vanillin, benzaldehyde (bitter almond, cherry) and 4-(r)-decanolide (fruity-fatty) are marketed on a scale of several thousand tons per year. their possible production by single-step biotransformations, bioconversions and de novo synthesis using microorganisms, plant cells or isolated enzymes is shown. the perspectives of bioprocesses for the oxifunctionalisation of lower terpenes by genetic ... | 1998 | 9487704 |
| chemical modification of hydroxynitrile lyase by selective reaction of an essential cysteine-sh group with alpha, beta-unsaturated propiophenones as pseudo-substrates. | 3-oxo-3-phenylpropyne and 3-oxo-3-phenylpropene were synthesized as active-site-directed irreversible inhibitors of the bitter almond hydroxynitrile lyase (ec 4.1.2.10), an fad-protein. the substrate and competitors (e.g. benzoate) decrease the rate of the inhibitor-mediated deactivation of the enzyme. by excess addition of either one of the two inhibitors, the deactivation process is shown to be pseudo-first order. the reaction with equimolar amounts of 3-oxo-3-phenylpropyne with the enzyme is ... | 1984 | 6697988 |
| aha!!, the smell of bitter almonds....cyanide poisoning. | | 1983 | 6572293 |
| [resorption of hydrocyanic acid from linseed]. | resorption of hydrocyanic acid after ingestion of linseed was investigated in 20 healthy volunteers and 5 patients. the persons investigated took a single dose of 30 g or of 100 g of linseed or they received throughout several weeks 15 g. t.i.d. one volunteer also took for purposes of comparison bitter almonds or potassium cyanide. before, during and after the periods of ingestion plasma levels of hydrocyanic acid and of thiocyanate were normal. during long-term trials urinary excretion of thioc ... | 1983 | 6302421 |
| cyanide poisoning after bitter almond ingestion. | | 1982 | 7072244 |
| inhibition of beta-glucosidases from almonds by cationic and neutral beta-glucosyl derivatives. | the beta-glucosidase (beta-d-glucoside glucohydrolase, ec 3.2.1.21) isoenzymes b from sweet and bitter almonds showed considerable differences in their kinetic and inhibition parameters, but both were inhibited much more strongly by basic beta-glucosyl derivatives than by their neutral analogs. the additional interaction energy apparently due to the basic character ranged from 18 kj/mol (4.3 kcal/mol) for beta-glucosylamine compared to beta-glucose to 28 kj/mol (6.9 kcal/mol) for n-benzyl-beta-g ... | 1978 | 418817 |
| amino acid sequence at the active site of beta-glucosidase a from bitter almonds. | beta-glucosidase a from bitter almonds was inhibited by the substrate analogue 6-bromo-3,4,5-trihydroxycyclo[2-3h]hex-1-ene oxide. incorporation of 2 mol inhibitor/mol of dimeric enzyme resulted in total loss of activity. from tryptic digests of the labeled enzyme two radioactive peptides were isolated and their sequence determined (binding site of inhibitor underlined): peptide i, containing approx. 60% of the label: ile-thr-glx-glx-gly-val--phe-gly-asp-ser-glx-(ala, asx2, pro)-lys and peptide ... | 1978 | 418815 |
| [prolonged survival of tumor bearing mice following feeding bitter almonds (author's transl)]. | | 1973 | 4763858 |
| [hydrocyanic acid poisoning by bitter almonds from the psychologic and therapeutic viewpoint]. | | 1965 | 14258581 |
| [poisoning by bitter almonds]. | | 1964 | 14129541 |
| [on the problem of the preparation of bitter almond water from concentrates]. | | 2009 | 13862628 |
| [on the effect of metals and its alloys on the quality of bitter almond oil water]. | | 2017 | 13862627 |
| nitrobenzene poisoning in infants due to inuction with false bitter almond oil. | | 1959 | 13847193 |
| [polarography in food chemistry. ii. detection and quantitate determination of benzaldehyde and nitrobenzene in bitter almond oil, synthetic benzaldehyde, bitter almond essence and flavoring]. | | 1955 | 13280356 |
| [poisoning by adulterated bitter almond oil (nitrobenzene)]. | | 1955 | 13303399 |
| poisoning due to artificial oil of bitter almonds. | | 1953 | 13096777 |
| [hydrocyanic acid in bitter almonds]. | | 1951 | 14858709 |
| [research on nitrobenzene in bitter almond oil]. | | 1950 | 14811207 |
| fatal poisoning from fifteen or twenty drops of the essential oil of bitter almonds. | | 1844 | 20793542 |