| [morphological changes in the endocrine pancreas of the rabbit after the administration of a morus alba extract]. | the authors examined the effect of an extract, obtained from the leaves of the plant morus alba on beta-cells of the endocrine pancreas of a rabbit after subcutaneous and parenteral administration. the most manifested morphologic changes were observed after subcutaneous administration under the conditions of a chronic experiment. there were degranulation of beta-cells of the langerhans islets of these animals developed at various degree and discovered by means of a light and electrone microscope ... | 1975 | 770142 |
| pharmacological studies on root bark of mulberry tree (morus alba l.) | pharmacological studies were done on the root bark of mulberry tree and pharmacological effects were compared with the clinical effects of "sohakuhi" in chinese medicine. n-butanol- and water-soluble fractions of mulberry root had similar effects except for those on the cadiovascular system. both fractions showed cathartic, analgesic, diuretic, antitussive, antiedema, sedative, anticonvulsant, and hypotensive actions in mice, rats, guinea pigs and dogs. there appears to be a correlation between ... | 1976 | 1003702 |
| n-containing sugars from morus alba and their glycosidase inhibitory activities. | the reexamination of n-containing sugars from the roots of morus alba by improved purification procedures led to the isolation of eighteen n-containing sugars, including seven that were isolated from the leaves of morus bombycis. these n-containing sugars are 1-deoxynojirimycin (1), n-methyl-1-deoxynojirimycin (2), fagomine (3), 3-epi-fagomine (4), 1,4-dideoxy-1,4-imino-d-arabinitol (5), 1,4-dideoxy-1,4-imino-d-ribitol (6), calystegin b2 (1 alpha,2 beta,3 alpha,4 beta-tetrahydroxy-nor-tropane, 7 ... | 1994 | 8050098 |
| purification and characterization of moran 20k from morus alba. | a new glycoprotein was purified from the aqueous methanolic extract of the root bark of morus alba which has been used as a component of antidiabetic remedy in oriental medicine. sds-page result shows that the molecular weight of the glycoprotein was approximately 20 kda. this new glycoprotein was named as moran 20k. the protein lowered blood glucose level in streptozotocin-induced hyperglycemic mice model and it also increased the glucose transport in cultured epididymis fat cells. the amino ac ... | 1999 | 10071952 |
| hypoglycaemic activity of four plants used in chilean popular medicine. | the hypoglycaemic activity of a 20% dried leaf infusion of bauhinia candicans benth. (leguminosae), galega officinalis l. (leguminosae), morus alba l. (moraceae) and rubus ulmifolius schott. (rosaceae), used for diabetes in chilean popular medicine, was evaluated in alloxan and streptozotocin induced hyperglycaemic rats. in normal rats the different infusions did not modify significantly the glycaemia in the period studied, but in diabetic rats different results were observed, depending on the d ... | 1999 | 10190178 |
| active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of rhodiola sacra. | the active-oxygen scavenging activity of 70 traditional herbal medicines used in china and japan as nourishing tonics were evaluated by electron spin resonance (esr) technique, in order to evaluate their effectiveness for anti-aging and to search for new active-oxygen scavengers from natural resources. most of the 70 herbal medicines showed scavenging activity with various intensities. areca catechu (methanol extract), dendrobium plicatile (methanol extract), juglans regia (water extract), paeon ... | 1999 | 10616967 |
| two flavonoids from the leaves of morus alba induce differentiation of the human promyelocytic leukemia (hl-60) cell line. | two flavonoids, quercetin-3-o-beta-d-glucopyranoside (1) and quercetin-3,7-di-o-beta-d-glucopyranoside (2), were isolated from the leaves of morus alba (moraceae). these two flavonoids exerted a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (hl-60) at the concentration of 2 x 10(-4) m. compound 2 also induced differentiation of the hl-60 cell line to express cd 66b and cd 14 antigens. these flavonoids exhibited significant free radical scavenging effec ... | 2000 | 10784426 |
| molecular characterization of a hydroxymethylglutaryl-coa reductase gene from mulberry (morus alba l.). | the genus morus consists of trees and shrubs, which are distributed in temperate and subtropical regions. commonly known as mulberry, a few of the morus species are valued for their foliage, which constitutes the chief feed for mulberry silkworms. steroids and isoprenoid compounds present in the foliage not only add nutritive factors to the feed but also contribute greatly to silkworm health and silk production. mevalonate synthesis, which is the first step in isoprenoid biosynthesis, is catalyz ... | 2000 | 10809002 |
| immunomodulating activity of a polysaccharide isolated from mori cortex radicis. | the immunomodulating activity of a polysaccharide isolated from morus alba (pma) root bark was examined in murine splenic lymphocytes. pma enhanced proliferation of splenic lymphocytes in a synergistic manner in the presence of mitogens. however, pma suppressed primary igm antibody production from b cells, which was activated with lipopolysaccharide, a polyclonal activator, or immunized with a t-cell dependent antigen sheep red blood cells. our observations showed that the immunomodulating activ ... | 2000 | 10896055 |
| [studies on the biosynthesis of sterol side chain in higher plants]. | campesterol (3) and dihydrobrassicasterol (4), typical c28-sterols in higher plants, are biosynthesized from a steroidal 24-ene precursor (desmosterol 1) via 24-methylenecholesterol (2) and 24-methyldesmosterol (5). a typical plant c29-sterol, sitosterol (6), is produced from 24-methylenecholesterol via isofucosterol (7) and 24-ethyldesmosterol (8). the biosynthetic mechanism, focussing stereochemical features, of these side-chain transformations has been studied in detail by feeding regio- and ... | 2000 | 11082699 |
| effects of mulberry leaves to replace rapeseed meal on performance of sheep feeding on ammoniated rice straw diet. | this study was conducted to investigate effects of leaves of mulberry tree (morus alba) as a protein supplement to isonitrogenously replace rapeseed meal (rsm) on performance of growing lambs offered ammoniated rice straw (abrs) (trial 1), and to evaluate the digestive characteristics of the abrs supplemented with different ratios of rsm and mulberry leaves in terms of in vitro gas production (trial 2). in trial 1, 45 huzhou lambs were divided into five equal groups according to their body weigh ... | 2001 | 11182305 |
| studies on the constituents of the leaves of morus alba l. | two novel prenylflavanes (1, 2) and a glycoside (3) of 1 were isolated along with six known compounds, isoquercitrin (4), astragalin (5), scopolin (6), skimmin (7), roseoside ii (8) and benzyl d-glucopyranoside (9), from the leaves of morus alba. the inhibitory activities of compounds 1, 2 and 3 on the oxidation of human low density lipoprotein (ldl) were investigated. | 2001 | 11217100 |
| interaction of a mulberry leaf lectin with a phytopathogenic bacterium, p. syringae pv mori. | two n-glycolylneuraminic acid-specific lectins, mll 1 and 2, from leaves of morus alba were studied for their anti-bacterial activity against p. syringae pv mori, which was a specific pathogenic bacterium of the mulberry leaf. mll 1 but not mll 2 was found to induce the agglutination of p. syringae pv mori. the mll 1 can induce the agglutination only at the exponential phase of the bacterial growth in a liquid medium and the agglutination was specifically inhibited by n-glycolylneuraminic acid, ... | 2001 | 11448749 |
| five new nortropane alkaloids and six new amino acids from the fruit of morus alba linne growing in turkey. | investigation of the constituents of the fruits of morus alba linne (moraceae) afforded five new nortropane alkaloids (1-5) along with nor-psi-tropine (6) and six new amino acids, morusimic acids a-f (7-12). the structures of the new compounds were determined to be 2alpha,3beta-dihydroxynortropane (1), 2beta,3beta-dihydroxynortropane (2), 2alpha,3beta,6exo-trihydroxynortropane (3), 2alpha,3beta,4alpha-rihydroxynortropane (4), 3beta,6exo-dihydroxynortropane (5), (3r)-3-hydroxy-12-[(1s,4s)-4-[(1s) ... | 2002 | 11848207 |
| cortex mori extract induces cancer cell apoptosis through inhibition of microtubule assembly. | the water extract from the root bark of cortex mori (cm, morus alba l.: sangbaikpi), a mulberry tree, has been known in chinese traditional medicine to have antiphlogistic, diuretic, and expectorant properties. in this study, the cytotoxicity of cm against tumor cells and its mechanism was examined. cm exhibited cytotoxic activity on k-562, b380 human leukemia cells and b16 mouse melanoma cells at concentrations of > 1 mg/ml. a dna fragmentation, parp cleavage, and nuclear condensation assay sho ... | 2002 | 12009034 |
| hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from morus alba. | chemical investigation of the etoh extract of morus alba l. (moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone b (2) and cudraflavone c (3), and oxyresveratrol (4). compounds 1 and 4 showed superoxide scavenging effects with the ic(50) values of 19.1 +/- 3.6 and 3.81 +/- 0.5 microm, respectively. compound 4 exhibited a dpph free radical scavenging effect (ic(50) = 23.4 +/- 1.5 microm). compounds 2 and 4 ... | 2002 | 12391560 |
| evaluation of natural products on inhibition of inducible cyclooxygenase (cox-2) and nitric oxide synthase (inos) in cultured mouse macrophage cells. | the inhibitors of prostaglandin biosynthesis and nitric oxide production have been considered as potential anti-inflammatory and cancer chemopreventive agents. in this study, we evaluated approximately 170 methanol extracts of natural products including korean herbal medicines for the inhibition of prostaglandin e(2) production (for cox-2 inhibitors) and nitric oxide formation (for inos inhibitors) in lipopolysaccharide (lps)-induced mouse macrophages raw264.7 cells. as a result, several extract ... | 2002 | 12413723 |
| administration of folium mori extract decreases nitric oxide synthase expression in the hypothalamus of streptozotocin-induced diabetic rats. | folium mori, the leaves of morus alba l., has traditionally been used for the treatment of diabetic hyperglycemia. it has been shown to induce enhanced nos expression in the hypothalamus of rats with streptozotocin (stz)-induced diabetes. in the present study, the effect of folium mori on the expression of nitric oxide synthase (nos) in the hypothalamus of stz-induced diabetic rats was investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (nadph-d) histochemistry. enhanced napd ... | 2002 | 12419890 |
| plant antimutagens and their mixtures in inhibition of genotoxic effects of xenobiotics and aging processes. | the antimutagenic effect of the bioactive compounds from fruits of morus alba l. (ma), punica granatum l. (pg), diospyros kaki l. (dk), cydonia oblonga mill. (co) and roots of glycyrrhiza glabra (gg) were investigated. the antimutagenic effects of compounds separately as well as their action in complex mixtures were studied on mutations induced by genotoxicants (x-rays, n-methylnitrosourea, cyclophosphamide, naf) and aging in bone marrow cell chromosomes from mice and rats. when tested separatel ... | 2002 | 12570329 |
| antiviral flavonoids from the root bark of morus alba l. | a prenylated flavonoid, moralbanone, along with seven known compounds kuwanon s, mulberroside c, cyclomorusin, eudraflavone b hydroperoxide, oxydihydromorusin, leachianone g and alpha-acetyl-amyrin were isolated from the root bark of morus alba l. leachianone g showed potent antiviral activity (ic(50) = 1.6 microg/ml), whereas mulberroside c showed weak activity (ic(50) = 75.4 microg/ml) against herpes simplex type 1 virus (hsv-1). their structures were elucidated by spectroscopic methods. | 2003 | 12648543 |
| kuwanon g: an antibacterial agent from the root bark of morus alba against oral pathogens. | kuwanon g was isolated from the ethyl acetate fraction of methanol extract of morus alba and its structure was elucidated by 13c-nmr, 1h-nmr and fab-ms. antibacterial activity of kuwanon g was investigated by the minimum inhibitory concentration (mic) test and the viable cell count method. mic of kuwanon g against streptococcus mutans causing dental caries was determined to be 8.0 microg/ml. the bactericidal test showed that kuwanon g completely inactivated s. mutans at the concentration 20 micr ... | 2003 | 12648813 |
| survival and development of lymantria monacha (lepidoptera: lymantriidae) on north american and introduced eurasian tree species. | lymantria monacha (l.) (lepidoptera: lymantriidae), the nun moth, is a eurasian pest of conifers that has potential for accidental introduction into north america. to project the potential host range of this insect if introduced into north america, survival and development of l. monacha on 26 north american and eight introduced eurasian tree species were examined. seven conifer species (abies concolor, picea abies, p. glauca, p. pungens, pinus sylvestris with male cones, p. menziesii variety gla ... | 2003 | 12650343 |
| the inhibitory action of pyrrolidine alkaloid, 1,4-dideoxy-1,4-imino-d-ribitol, on eukaryotic dna polymerases. | the pyrrolidine alkaloids mimicking the structures of pentose with nitrogen in the ring are known to be inhibitors of glycosidases. we report here that a compound belonging to this category is an inhibitor of eukaryotic dna polymerases. among the eight naturally occurring pyrrolidine alkaloids we tested, only one compound, 1,4-dideoxy-1,4-imino-d-ribitol (drb), which was purified from the mulberry tree (morus alba), strongly inhibited the activities of eukaryotic dna polymerases with ic50 values ... | 2003 | 12705887 |
| inhibitory effects of ramulus mori extracts on melanogenesis. | to develop an active agent for skin whitening, the inhibitory effects of 285 plant extracts on tyrosinase activity were examined, and one plant extract having tyrosinase inhibition activity was chosen. ramulus mori (young twigs of morus alba l.) extracts showed inhibition activity in tyrosinase and melanin synthesis in b-16 melanoma cells. to clarify the mechanism of its inhibition on melanogenesis, the effect of r. mori extracts on tyrosinase activity, synthesis, and gene expression was evaluat ... | 2003 | 12715091 |
| mulberry (morus alba) leaves as human food: a new dimension of sericulture. | mulberry leaf is commonly used for sericulture in almost every part of the world but its potential to be utilized for human consumption is not well recognized. this paper deals with development of mulberry leaf powder and its use with wheat flour to develop paratha, the most common food item of breakfast and dinner in the indian diet. the optimum ratio of the mulberry leaf powder and wheat flour (mlp-wf) mix for preparation of paratha on the basis of sensory quality was found to be 1:4. the prot ... | 2003 | 14522686 |
| antinephritis and radical scavenging activity of prenylflavonoids. | antinephritis activity of 5 prenylflavonoids similar to glabridin (1-5), isolated from morus alba, artocarpus communis, glycyrrhiza uralensis and g. inflata, was evaluated in mice with glomerular disease (masugi-nephritis). oral administrations of artonin e (2) or licochalcone a (4) for 10 days (30 mg kg(-1) day(-1)) reduced the amount of urinary protein excretion compared to nephritic mice. esr spectroscopy demonstrated that morusin (1) and licorisoflavan a (5) increased the radical intensity o ... | 2003 | 14630182 |
| in-vitro and in-vivo anti-inflammatory effect of oxyresveratrol from morus alba l. | the antioxidative effects of mulberroside a and oxyresveratrol obtained from mori cortex were examined. mulberroside a and oxyresveratrol showed an inhibitory effect against feso4/h2o2-induced lipid peroxidation in rat microsomes and a scavenging effect on 1,1-diphenyl-2-picrylhydrazyl radical. the anti-inflammatory effects of mulberroside a and oxyresveratrol using the carrageenin-induced model of inflammation were investigated in rats. mulberroside a and oxyresveratrol significantly reduced pa ... | 2003 | 14738598 |
| the effect of medicinal plants of islamabad and murree region of pakistan on insulin secretion from ins-1 cells. | in vitro testing of the extracts of medicinal plants collected from islamabad and the murree region on insulin secretagogue activity was carried out. dried ethanol extracts of all plants (zh1-zh19) were dissolved in ethanol and dmso, and tested at various concentrations (between 1 and 40 microg/ml) for insulin release from ins-1 cells in the presence of 5.5 mm glucose. glibenclamide was used as a control. promising insulin secretagogue activity in various plant extracts at 1, 10, 20 and 40 micro ... | 2004 | 14750205 |
| folk pharmaceutical knowledge in the territory of the dolomiti lucane, inland southern italy. | an ethnopharmacognostic survey on the traditional pharmaceutical knowledge (tphk) of old and newly introduced natural remedies used for healing humans in a small mountainous area in central lucania, inland southern italy, was carried out using classical ethnographical and ethnobiological methods. approximately 110 remedies of plant origin (belonging to 103 botanical taxa), 30 of animal origin and 20 mineral or industrial (non-pharmaceutical) products were recorded. among these remedies, the comm ... | 2004 | 15507363 |
| preliminary efficacy and safety of oral suspension sh, combination of five chinese medicinal herbs, in people living with hiv/aids ; the phase i/ii study. | to evaluate the preliminary efficacy and safety of the mixture of drug extracts from 5 chinese medicinal herbs (sh), in the treatment of human immunodeficiency virus (hiv) infection among people living with hiv/aids (plwha). | 2004 | 15516007 |
| promoting effect and recovery activity from physical stress of the fruit of morus alba. | we examined the effects of the fruit of m. alba extracts on the changes of the monoamine oxidase (mao) activities during and after the physical exercise in rat. each activity was measured by used serotonin(5-ht) and benzylamine as substrate. lactate dehydrogenase(ldh) activity and the concentrations of lactate in blood which were clinical indexes of physical exercise were also determined to compare with the relation of mao activities. those activities during and after the physical exercise have ... | 2004 | 15630209 |
| antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: morus alba l., morus mongolica schneider, broussnetia papyrifera (l.) vent, sophora flavescens ait and echinosophora koreensis nakai. | antimicrobial activity of the 18 prenylated flavonoids, which were purified from five different medicinal plants, was evaluated by determination of mic using the broth microdilution methods against four bacterial and two fungal microorganisms (candida albicans, saccaromyces cerevisiae, escherichia coli, salmonella typhimurium, staphylococcus epidermis and s. aureus). papyriflavonol a, kuraridin, sophoraflavanone d and sophoraisoflavanone a exhibited a good antifungal activity with strong antibac ... | 2004 | 15636183 |
| screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity. | doxorubicin is an important and effective anticancer drug widely used for the treatment of various types of cancer but its clinical use is limited by dose-dependent cardiotoxicity. elevated tissue levels of cellular superoxide anion/oxidative stress are a mechanism by which doxorubicin-induced cardiotoxicity. selected medicinal plant extracts were tested for their antioxidant capacity and cardioprotective effect against doxorubicin-induced cardiotoxicity. the cardiac myoblasts h9c2 were incubate ... | 2005 | 15667600 |
| mulberry (morus alba l.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in ldl receptor-deficient mice. | the effects of dietary consumption of mulberry (morus alba l.) leaves and their major flavonol glycoside, quercetin 3-(6-malonylglucoside) (q3mg), on the development of atherosclerotic lesions, in relation to the susceptibility of plasma ldl to oxidative modification, was studied in ldl receptor-deficient (ldlr-/-) mice. male mice aged 8 wk were randomly assigned to 4 groups (control, quercetin, q3mg, and mulberry). the control group was fed an atherogenic-diet containing 3 g cholesterol and 15 ... | 2005 | 15795425 |
| benzo[a]pyrene co-metabolism in the presence of plant root extracts and exudates: implications for phytoremediation. | benzo[a]pyrene, a high molecular weight (hmw) polycyclic aromatic hydrocarbon (pah) was removed from solution by sphingomonas yanoikuyae jar02 while growing on root products as a primary carbon and energy source. plant root extracts of osage orange (maclura pomifera), hybrid willow (salix albaxmatsudana), or kou (cordia subcordata), or plant root exudates of white mulberry (morus alba) supported 15-20% benzo[a]pyrene removal over 24 h that was similar to a succinate grown culture and an unfed ac ... | 2005 | 15862401 |
| hypoglycemic effect of egyptian morus alba root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats. | the hypoglycemic activity of the flavonoids rich fraction of 70% alcohol extract of the egyptian morus alba root bark (mrbf-3) was evaluated after its oral administration to streptozotocin-induced diabetic rats. diabetes was induced by injection of 60 mg kg(-1) i.p. the administration of mrbf-3 to streptozotocin (stz)-diabetic rats for 10 days in a dose of 200 and 400 mg kg(-1)day(-1) was not significant. however, administration of mrbf-3 for 10 days (600 mg kg(-1)day(-1)) significantly reduced ... | 2005 | 15885940 |
| mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. | anthocyanins, present in various fruits and vegetables as natural colorant, have been well characterized to be involved in various bioactive properties and are wildly used for their antioxidant properties. furthermore, recent studies have revealed pleiotropic anticancer and antiproliferative capabilities of anthocyanin. berry extract contains high amounts of anthocyanins and is commonly used in diet or in some therapeutic applications. in this study, we first observed that cyanidin 3-rutinoside ... | 2006 | 15975709 |
| the dual actions of morin (3,5,7,2',4'-pentahydroxyflavone) as a hypouricemic agent: uricosuric effect and xanthine oxidase inhibitory activity. | hyperuricemia is associated with a number of pathological conditions such as gout. lowering of elevated uric acid level in the blood could be achieved by xanthine oxidase inhibitors and inhibitors of renal urate reabsorption. some natural compounds isolated from herbs used in traditional chinese medicine have been previously demonstrated to possess xanthine oxidase inhibitory activities. in the present investigation, morin (3,5,7,2',4'-pentahydroxyflavone), which occurs in the twigs of morus alb ... | 2006 | 16169936 |
| inhibitory effects of morus alba on compound 48/80-induced anaphylactic reactions and anti-chicken gamma globulin ige- mediated mast cell activation. | we investigated the effects of hot-water extract from the root bark of morus alba (hema) on anaphylactic reactions. using in vitro and in vivo experiments, we examined whether hema could inhibit compound 48/80-induced systemic anaphylactic shock and anti-chicken gamma globulin (cgg) ige-mediated rat peritoneal mast cell activation. hema significantly inhibited systemic anaphylaxis induced by the compound 48/80 in mice. hema also significantly inhibited the passive cutaneous anaphylaxis activated ... | 2005 | 16204934 |
| amelioration effects of traditional chinese medicine on alcohol-induced fatty liver. | to examine the effects of traditional chinese medicine (tcm) on alcohol-induced fatty liver in rats. tcm consists of astragalus membranaceus, morus alba, crataegus pinnatifida, alisma orientale, salvia miltiorrhiza, and pueraria lobata. | 2005 | 16222745 |
| effects of morus alba leaf extract on the production of nitric oxide, prostaglandin e2 and cytokines in raw264.7 macrophages. | morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit no production in lps-activated raw264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 microg/ml. lps-induced pge2 production was significantly reduced only by butanol fraction. in addition, m. alba leaf extract and its fractions significantly decreased the production of tnf-alpha. these findings suggest that m. alba leaf extract seems to be ... | 2005 | 16229967 |
| hypolipidemic and antioxidant effects of morus alba l. (egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats. | the 70% alcohol extract of the egyptian morus alba l. root bark was fractionated over cellulose cc eluted with water, 50% methanol and finally with 100% methanol to yield 3 fractions (mrbf-1, mrbf-2 and mrbf-3), respectively. in continuation of chromatographic purification of 70% alcohol extract fractions of the egyptian m. alba l. root bark, 4 compounds namely: mulberroside a, 5,7,2'-trihydroxyflavanone-4'-o-beta-d-glucoside and albanols a and b were isolated from mrbf-2 for the first time from ... | 2006 | 16313926 |
| traditional chinese medicine improves dysfunction of peroxisome proliferator-activated receptor alpha and microsomal triglyceride transfer protein on abnormalities in lipid metabolism in ethanol-fed rats. | we report the effects of traditional chinese medicine (tcm) on alcohol-induced fatty liver in rats. tcm consists of astragalus membranaceus, morus alba, crataegus pinnatifida, alisma oriental, salvia miltiorrhiza and pueraria lobata. the rats were separated randomly into five groups; the cd group (n=10), which was fed a control diet for 10 weeks, the ed group (n=10), which was fed an isocaloric liquid diet containing ethanol for 10 weeks and given daily oral doses of tcm (0.222 g/kg/day; tcm222, ... | 2005 | 16410638 |
| enhancement of neuroprotection of mulberry leaves (morus alba l.) prepared by the anaerobic treatment against ischemic damage. | several neurological disorders such as alzheimer's and parkinson's diseases have been attributed to gamma-aminobutyric acid (gaba) depletion in the brain. in order to provide a pharmacological basis for the neuroprotective actions of the enhanced accumulation of gaba in mulberry leaves (ml) against cerebral ischemia in vitro and in vivo, a process was developed to enhance the accumulation of gaba in mulberry leaves (gaml) as a result of the various anaerobic treatments. the gaba concentrations w ... | 2006 | 16462030 |
| cosmetic applications of selected traditional chinese herbal medicines. | because tyrosinase catalyzes melanin synthesis, tyrosinase inhibitors are important in cosmetic skin-whitening. oxidative stress contributes to skin aging and can adversely affect skin health, which means antioxidants active in skin cells may support skin health. we examined 25 traditional chinese herbal medicines that might be useful for skin-whitening and skin health. extracts (100microg/ml) were tested for cytotoxicity on human epidermal melanocytes (hemn); 12 exhibited low cytotoxicity. thei ... | 2006 | 16497459 |
| inhibitory effects of extractives from leaves of morus alba on human and rat small intestinal disaccharidase activity. | the inhibitory effect on human and rat intestinal disaccharidase by the extractive from the leaves of morus alba (elm) containing 0.24 % 1-deoxynojirimycin equivalent and its inhibitory activities were investigated by the modified dahlqvist method. in the presence of 1000-fold diluted elm solution, the sucrase activity of four human samples was inhibited by 96 % and that of maltase and isomaltase by 95 and 99 %, respectively. the activities of trehalase and lactase were inhibited by 44 and 38 %, ... | 2006 | 16611383 |
| effects of oral administration of some herbal extracts on food consumption and blood glucose levels in normal and streptozotocin-treated diabetic rats. | previous studies in our laboratories suggest that oral administration of some herbal extracts reduce blood glucose concentrations in rats, possibly by interfering with food consumption and/or gastrointestinal absorption of food. accordingly, we monitored the amounts of food consumed and body weights in separate groups of nondiabetic and streptozotocin-treated diabetic rats, orally treated with some plant extracts (20 mg 100 g -1 body weight) daily for 5 weeks. control animals were administered t ... | 2006 | 16801983 |
| colorimetric heparinase assay for alternative anti-metastatic activity. | heparanase has been previously associated with the metastatic potential, inflammation, and angiogenesis of tumor cells. heparanase activity has been detected by means of uv absorption, radiolabeled substrates, electrophoretic migration, and heparan sulfate affinity assays. however, those methods have proven to be somewhat problematic with regards to application to actual biological samples, the accessibility of the immobilized substrates, experimental sensitivity, and the separation of degraded ... | 2006 | 16806278 |
| determination of trace elements in herbal tea products and their infusions consumed in thailand. | nineteen elements, mg, al, ca, v, cr, mn, fe, co, ni, cu, zn, se, sr, sb, ba, as, cd, hg, and pb, were determined in three types of popular herbal tea products, gynostemma pentaphyllum, camellia sinensis, and morus alba. these herbal tea products, both imported and locally made products, are widely consumed in thailand and worldwide. microwave-assisted acid digestion was used for all of the samples, and the element contents were determined by icp-ms. the concentrations of all elements varied amo ... | 2006 | 16939361 |
| comparison of genetic transformation in morus alba l. via different regeneration systems. | three different regeneration systems, viz. direct regeneration of adventitious shoot buds from explant, regeneration through callus cultures and somatic embryos were compared to see their effect on transfer of neomycin phosphotransferase (nptii) and beta-glucuronidase (gus) reporter gene (gus) to morus alba clone m5, through agrobacterium tumefaciens mediated transformation. pre-conditioning and co-cultivation durations had a marked effect on transformation frequency. the highest transformation ... | 2007 | 16951950 |
| ethnomedicines used in trinidad and tobago for urinary problems and diabetes mellitus. | this paper is based on ethnobotanical interviews conducted from 1996-2000 in trinidad and tobago with thirty male and female respondents. | 2006 | 17040567 |
| mulberry leaf aqueous fractions inhibit tnf-alpha-induced nuclear factor kappab (nf-kappab) activation and lectin-like oxidized ldl receptor-1 (lox-1) expression in vascular endothelial cells. | mulberry (morus alba l., family moraceae) leaf extracts have various biological effects including inhibition of oxidative modification of low-density lipoprotein (ldl), which is the major cause of atherosclerosis. endothelial dysfunction elicited by oxidized ldl (ox-ldl) has been implicated in atherogenesis. lectin-like ox-ldl receptor-1 (lox-1), a cell-surface receptor for atherogenic ox-ldl, appears to mediate ox-ldl-induced inflammation, which may be crucial in atherogenesis. previous studies ... | 2007 | 17055514 |
| seasonal variations in isoprene emission from tropical deciduous tree species. | isoprene is a dominant constituent of the global biogenic volatile organic compounds budget. it plays an important role in regulating the atmospheric trace gas composition including tropospheric ozone concentrations. in this study, monthly measurements of isoprene emission rates were carried out over a 1-year period (december 2002-november 2003) from four indian deciduous tree species, namely ficus relegiosa, ficus infectoria, pongamia pinnata, and morus alba, using branch enclosure method. sign ... | 2007 | 17242968 |
| enzymatic formation of unnatural cytokinin analogs by adenylate isopentenyltransferase from mulberry. | a cdna encoding adenylate isopentenyltransferase (aipt) was cloned from young leaves of mulberry (morus alba) by a homology-based rt-pcr. a recombinant enzyme expressed in escherichia coli catalyzed prenyl transfer from dmapp to the n6 amino group of adp and atp, respectively, while amp was a poor substrate of the enzyme. interestingly, m. alba aipt also accepted dadp, datp, cdp, and gdp as the prenyl acceptors, and ipp, hmbpp, and gpp as the prenyl donors, to produce a series of cytokinin analo ... | 2007 | 17320045 |
| morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hurat1) expressed in human embryonic kidney cells. | in allopurinol-allergic patients, uricosuric agents are often used in the treatment of hyperuricemia. the existing uricosuric agents are not without problems and the availability of better and safer alternatives is highly desirable. our previous study (j pharmacol exp ther (2006) 316:169-175) has demonstrated that morin (3,5,7,2',4'-pentahydroxyflavone), which occurs in the twigs of morus alba l. documented in traditional chinese medicinal literature for treatment of conditions akin to gout, is ... | 2007 | 17325024 |
| hypolipidemic effect of flavonoids from mulberry leaves in triton wr-1339 induced hyperlipidemic mice. | the aim of this study was to investigate the hypolipidemic effect of the total flavonoids from mulberry leaves (mtf) in hyperlipidemic mice. the total flavonoids have been isolated from mulberry (morus alba l.) leaves and purified by macroporous resins. after that, the content of mtf is 581.7 mg g-1 in dried product. the hypolipidemic effect of mtf has been evaluated in triton wr-1339 (400 mg kg-1) induced hyperlipidemic mice. the beneficial effects of mtf on serum lipid levels are more signific ... | 2007 | 17392121 |
| food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. | mulberry 1-deoxynojirimycin (dnj), a potent glucosidase inhibitor, has been hypothesized to be beneficial for the suppression of abnormally high blood glucose levels and thereby prevention of diabetes mellitus. however, dnj contents in commercial mulberry products were as low as about 0.1% (100 mg/100 g of dry product), implying that the bioavailability of dnj might not be expected. we carried out studies in two directions: (1) production of food-grade mulberry powder containing a maximally high ... | 2007 | 17555327 |
| in vitro hypoglycemic activity of methanolic extract of some indigenous plants. | pakistan is rich in medicinally important plants and has ancient herbal treatment methods. present work is based on the study of six indigenous plants eugenia jambolana, lawsonia inermis, momordica charantia, morus alba, nigella sativa and trigonella foenum graecum which show the inhibitory effect of glucose utilization, and are in use as hypoglycemic agents of varying degree in traditional system of medicine. the glucose uptake activity of (methanolic extracts) of these plants was tested in vit ... | 2007 | 17604247 |
| natural iminosugar derivatives of 1-deoxynojirimycin inhibit glycosylation of hepatitis viral envelope proteins. | a silkworm (bombyx mori l.) extract known to contain naturally occurring iminosugars, including 1-deoxynojirimycin (1-dnj) derived from the mulberry tree (morus alba l.), was evaluated in surrogate hcv and hbv in vitro assays. antiviral activity of the silkworm extract and one of its purified constituents, 1-dnj, was demonstrated against bovine viral diarrhea virus (bvdv) and gb virus-b (gbv-b), both members of the flaviviridae family, and against woodchuck hepatitis virus (whv) and hepatitis b ... | 2007 | 17978803 |
| regulation of obesity and lipid disorders by herbal extracts from morus alba, melissa officinalis, and artemisia capillaris in high-fat diet-induced obese mice. | melissa officinalis l. (labiatae), morus alba l. (moraceae), and artemisia capillaris thunb. (compositae) are suggested to be involved in the regulation of hyperlipidemia. we hypothesized that ob-x, a mixture of three herbs, morus alba, melissa officinalis and artemisia capillaris [corrected] improves lipid metabolism, body weight gain and adiposity and that peroxisome proliferator-activated receptor alpha (pparalpha) is associated with these events. mice fed a high-fat diet for 12 weeks exhibit ... | 2008 | 18023310 |
| biphasic effects of morus alba leaves green tea extract on mice in chronic forced swimming model. | in this study, the effects of an aqueous extract of morus alba leaves green tea (me) on mouse behaviors (depression, anxiety, climbing activity and thermal response), muscle coordination and muscle strength were studied. male irc mice received a single intraperitoneal injection of either the me, desipramine or diazepam. thirty minutes after injection, the mice were tested in all experimental models. a significant antidepressant-like effect could be detected in the animals receiving either 100 or ... | 2008 | 18386251 |
| [study on cytotoxic activities on human leukemia cell line hl-60 by flavonoids extracts of scurrula parasitica from four different host trees]. | to compare the anticancer effects of flavonoids extracts of scurrula parasitica from different host trees in vitro. | 2008 | 18533504 |
| novel anti-adherence activity of mulberry leaves: inhibition of streptococcus mutans biofilm by 1-deoxynojirimycin isolated from morus alba. | the present study focused on isolation, characterization and evaluation of purified compounds from morus alba against streptococcus mutans biofilm formation. | 2008 | 18565974 |
| a new source of whitening agent from a thai mulberry plant and its betulinic acid quantitation. | protection of human body against the harmful ultraviolet exposure is nowadays more important and interesting. melanin, a group of bio-pigments, acts as a natural solar filter absorbing and reflecting most of the uv radiation passing through the layer of skin. over production of the pigments can create a health problem, hyperpigmentation. tyrosinase is a key enzyme, which catalyzes the conversion of l-tyrosine to l-dihydroxyalanine (l-dopa), therefore tyrosinase inhibitors are used in various ski ... | 2008 | 18569714 |
| [control in vitro tick (boophilus microplus; acari: ixodidae) through plant extracts]. | control in vitro tick (boophilus microplus; acari: ixodidae) through plant extracts. hydro-alcohol extracts of ten tropical plants were tested by the immersion method on mature ticks (boophilus microplus canestrini 1887). the biological evaluation was made with raw hydro alcoholic extracts (r-oh) to determine the most promissory compounds, which later were fractioned in their polar and non-polar parts. the polar parts showed a significantly inferior effect. the species that produced the highest ... | 2008 | 18624244 |
| biological control against bacterial wilt and colonization of mulberry by an endophytic bacillus subtilis strain. | forty-five bacterial isolates were collected from surface-sterilized leaves of mulberry (morus alba l.). by screening their antagonistic activities against ralstonia solanacearum in vitro, four isolates showed a remarkable inhibitory effect. the evaluation of the antagonistic strains against bacterial wilt of mulberry indicated that the strain lu144 effectively reduced disease incidence. in the greenhouse, lu144 displayed effective biological control against bacterial wilt of mulberry when it wa ... | 2008 | 18631174 |
| screening of nepalese crude drugs traditionally used to treat hyperpigmentation: in vitro tyrosinase inhibition. | south-east asian population is daily exposed to strong sunlight. as a result, the majority of population will have darker, ethnic skin. moreover, many people suffer from dark spots, hyperpigmentation, which is considered to be a skin disorder and causes psychological disturbance. to treat dark spots, most of the population will still rely on traditionally used crude drugs, knowledge about which is transferred from generation to generation. fifty-two crude drugs were selected based on the survey ... | 2008 | 18822041 |
| endothelium-independent relaxation and contraction of rat aorta induced by ethyl acetate extract from leaves of morus alba (l.). | based on screening for vasoactive traditional chinese medicinal herbs, the present study was performed to investigate the vasoactive effects of an ethyl acetate extract from leaves of morus alba (l.) (elm) on rat thoracic aorta and the mechanisms underlying these effects. | 2008 | 18948182 |
| trace element levels in some dried fruit samples from turkey. | trace element levels in nine different dried fruit samples from kayseri, turkey were determined by flame atomic absorption spectrometry after dry and wet digestion methods. good accuracy was assured by the analysis of standard reference material (nist-srm 1515-apple leaves). the contents of trace elements in the samples were determined in the ranges of 1.68-4.52, 0.6-9.4, 5.5-12.4, 6.76-64.1, 4.74-25.5, 0.2-1.78, 0.8-6.17 and 0.1-0.81 microg/g for copper, nickel, lead, iron, manganese, cobalt, c ... | 2008 | 18991103 |
| the nutritive value of mulberry leaves (morus alba) as a feed supplement for sheep. | a study to determine the nutritive value of mulberry (morus alba) leaves in sheep diets was conducted. mulberry leaves contained (g kg(-1) on dry matter basis): 163 ash, 201 crude protein, 120 crude fibre, 37 ether extracts, 479 nitrogen-free extracts, 268 neutral detergent fibre, 148 acid detergent fibre, 41 acid detergent lignin, 121 cellulose and 107 hemicellulose, while the in vitro true digestibility of dry matter was 89.8%. the nitrogen (n) solubility, determined using: a) mcdougall's buff ... | 2009 | 19052898 |
| mulberry leaf ameliorates the expression profile of adipocytokines by inhibiting oxidative stress in white adipose tissue in db/db mice. | previous study showed that mulberry (morus alba l.) leaf (ml) ameliorates atherosclerosis in apoe(-/-) mice. although the adipocytokine dysregulation is an important risk factor for atherosclerotic cardiovascular disease, the effect of ml on metabolic disorders related to adipocytokine dysregulation and inflammation has not been studied. therefore, we studied the effects of ml in metabolic disorders and examined the mechanisms by which ml ameliorates metabolic disorders in db/db mice. we treated ... | 2009 | 19070857 |
| complementary alternative medicine use in children with type 1 diabetes mellitus in erzurum, turkey. | the aims of this study were: (i) to determine the types of complementary and alternative medicine use among children with type i diabetes mellitus as reported by parents and (ii) to describe sociodemographic and medical factors associated with the use of such treatments in families residing in eastern turkey. | 2009 | 19077023 |
| morus alba leaf extract stimulates 5'-amp-activated protein kinase in isolated rat skeletal muscle. | morus alba (mulberry) leaf is a natural therapeutic agent that has been shown to have an antidiabetic effect. we explored the possibility that 5'-amp-activated protein kinase (ampk) is involved in metabolic enhancement by the morus alba leaf. | 2009 | 19101621 |
| the production of nitric oxide and prostaglandin e2 in peritoneal macrophages is inhibited by andrographis paniculata, angelica sinensis and morus alba ethyl acetate fractions. | traditional chinese medicine herbs (tcmhs) are used in medicines as well as in daily dietary supplements in asia. in this study, we employed pnf-kappab-luc or pifn-gamma-luc and balb/c mice peritoneal macrophages or splenocytes to investigate both the immune and inflammatory effects of six selected plant species. | 2009 | 19111919 |
| scale insects and mealy bugs (homoptera: coccoidea) attacking deciduous fruit trees in the western north coast of alexandria, egypt. | this investigation covered a survey of scale insects and mealy bugs infesting ten growing species of deciduous fruit trees in three localities in alexandria govemorate. these localities were merghem, burg el-arab, and el-nahda about 50 km. west of alexandria under both rain-fed and irrigation system conditions. the common inspected fruit trees were fig, white mulberry, pomegranate, apple, pear, apricot, european plum, peach, almond, and persimmon. it was shown that a group of twenty scale insect ... | 2008 | 19226793 |
| neutralization of local and systemic toxicity of daboia russelii venom by morus alba plant leaf extract. | antivenom therapy is the current best therapy available for the treatment of fatal snake envenomation. however, the antivenom offers less or no protection against local effects such as extensive edema, hemorrhage, dermo-, myonecrosis and inflammation at the envenomed region. viperidae snakes are highly known for their violent local effects and such effects have been commonly treated with plant extracts without any scientific validation in rural india. in this investigation morus alba plant leaf ... | 2009 | 19235141 |
| melanin-concentrating hormone-1 receptor antagonism and anti-obesity effects of ethanolic extract from morus alba leaves in diet-induced obese mice. | in korea, morus alba leaves have been traditionally administered as natural therapeutic agent for the alleviating dropsy and diabetes. | 2009 | 19330910 |
| antihyperglycemic, antioxidant and antiglycation activities of mulberry leaf extract in streptozotocin-induced chronic diabetic rats. | in thailand, beverages containing mulberry leaf (morus alba l.) are believed to promote good health, especially in people with diabetes. we examined the effects of long-term administration of an ethanolic extract of mulberry leaf (ma) on blood glucose, oxidative damage, and glycation in streptozotocin-induced diabetic rats. daily administration of 1 g/kg ma for six weeks decreased blood glucose by 22%, which was comparable to the effect of 4 u/kg insulin. lipid peroxidation, measured as malondia ... | 2009 | 19434497 |
| xia-bai-san inhibits lipopolysaccharide-induced activation of intercellular adhesion molecule-1 and nuclear factor-kappa b in human lung cells. | xia-bai-san (xbs) is a traditional chinese medicine that has been used clinically for centuries in asian countries to treat some types of common cold and asthma-like diseases similar to infantile pneumonia and childhood bronchitis. in previous studies, xbs was found to suppress the inflammatory process induced in lungs of mice treated with lipopolysaccharide (lps). | 2009 | 19454309 |
| in vivo hypoglycemic effects of phenolics from the root bark of morus alba. | moracin m (1), steppogenin-4'-o-beta-d-glucosiade (2), mullberroside a (3) were isolated from the root bark of morus alba l. and identified by spectral evidence. compounds 1, 2 and 3 were studied in hypoglycemic effects on alloxan-diabetic mice. the results showed that compounds 1, 2 and 3 all produced hypoglycemic effects. the compound 2 in a dose of 50 mg/kg exerted significant effect (p<0.05), 2 and 3 in a dose of 100 mg/kg exerted obviously effect (p<0.01). meantime, the compound 1 in a dose ... | 2009 | 19545615 |
| suppressive response of confections containing the extractive from leaves of morus alba on postprandial blood glucose and insulin in healthy human subjects. | abstract: | 2009 | 19602243 |
| mulberry leaf extract inhibits vascular smooth muscle cell migration involving a block of small gtpase and akt/nf-kappab signals. | mulberry, the fruit of morus alba, is commonly used in chinese medicines because of its many pharmacologic effects. mulberry leaves contain many phenolic antioxidants that can reduce cardiovascular disease. atherosclerosis involves proliferation and migration of vascular smooth muscle cell (vsmc). thus, we investigated the mechanisms by which mulberry leaf extract (mle) might inhibit migration of vsmc. mle was rich in polyphenols (44.82%), including gallic acid, protocatechuic acid, catechin, ga ... | 2009 | 19761240 |
| mulberry leaf extract restores arterial pressure in streptozotocin-induced chronic diabetic rats. | free radical-induced vascular dysfunction plays a key role in the pathogenesis of vascular disease found in chronic diabetic patients. morus alba (ma) leaf extract is promoted for good health especially in diabetic patients. interestingly, antidiabetic and antioxidant activities of ma have been reported in experimental animals. thus, the hypothesis of this study was that the long-term treatment with ma could improve vascular reactivity of chronic diabetic rats. to test this hypothesis, we examin ... | 2009 | 19761895 |
| three major metabolites of mulberroside a in rat intestinal contents and feces. | mulberroside a, a major stilbene constituent of morus alba l. (moraceae), displays significant antitussive and antiasthmatic effects in animals. as part of our ongoing research on its biotransformation in rats, mulberroside a was orally administered to rats, and the metabolites in the gastrointestinal contents and feces were investigated. three major metabolites were isolated from the feces of rats and identified as oxyresveratrol-2- o- beta- d-glucopyranoside ( 1), oxyresveratrol-3'- o- beta- d ... | 2010 | 19787570 |
| comparative proteomic analysis provides new insights into mulberry dwarf responses in mulberry (morus alba l.). | mulberry dwarf (md) is a serious infectious disease of mulberry caused by phytoplasma. infection with md phytoplasma results in stress phenotypes of yellowing, phyllody, stunting, proliferation, and witches' broom. physiological and biochemical analysis has shown that infection with md phytoplasma causes an increase in soluble carbohydrate and starch content, and a decrease in the net photosynthesis rate, carboxylation efficiency, and pigment content of leaves. furthermore, damage to the chlorop ... | 2009 | 19834890 |
| characterization of the polyphenolic fraction of morus alba leaves extracts by hplc coupled to a hybrid it-tof ms system. | infusions or dried leaves from morus alba (l., moraceae) have long been used in folk medicine for the prevention or treatment of several diseases. despite the great interest in determining the role of phytonutrients as potential therapeutic agents, and the rising demand of natural sources with nutraceutic benefits, the antioxidant content of many foodstuffs is unknown, making accurate estimation for human dietary consumption and the correlation to human diseases difficult. the high content in po ... | 2009 | 19877143 |
| morphology and oxidative physiology of boron-deficient mulberry plants. | the aim of the study was to induce b deficiency symptoms and to relate the generation of reactive oxygen species (ros) and altered cellular redox environment with the effects of b deficiency in mulberry (morus alba l.) cv. kanva-2 plants. study was undertaken on antioxidant responses, malondialdehyde (mda) content as an indicator of oxidative damage and ratio of dehydroascorbate (dha) to ascorbic acid (asa) as an index of cellular redox environment in b-deficient (0.0 microm) and b-supraoptimal ... | 2010 | 19933494 |
| anti-inflammatory effect of resveratrol by inhibition of il-8 production in lps-induced thp-1 cells. | resveratrol is a polyphenol compound and prominent anti-inflammatory agent found in plants, including the fruits of morus alba. however, the therapeutic mechanisms of resveratrol remain largely unclear. to gain insight into the biological effects of resveratrol, we examined its influence on lps-induced il-8 production in the human monocytic cell line, thp-1. in inflammatory diseases, il-8 plays a central role in the initiation and maintenance of inflammatory response. in the present study, il-8 ... | 2009 | 19938227 |
| melanin-concentrating hormone-1 receptor binding activity of pheophorbides isolated from morus alba leaves. | the time-resolved fluorescence technique based on melanin-concentrating hormone (mch) receptor subtype-1 (mch-1 receptor) binding assay was adopted to carry out a bioassay-guided fractionation of the methanol extract of morus alba leaves. this fractionation and purification led to the isolation of two compounds identified as pheophorbide a methyl ester and 13(2)(s)-hydroxypheophorbide a methyl ester. these active pheophorbides exhibited potent inhibitory activity in binding of europium-labeled m ... | 2010 | 20013814 |
| anti-dopaminergic effect of the methanolic extract of morus alba l. leaves. | to evaluate the effect of methanolic extract of morus alba l. leaves on dopaminergic function. | 2008 | 20040961 |
| immunomodulatory activity of methanolic extract of morus alba linn. (mulberry) leaves. | the leaves of morus alba linn. (family: moraceae) commonly known as mulberry are mainly used as food for the silkworms and they are sometimes eaten as vegetable or used as cattle fodder in different parts of the world. the effect of morus alba on the immune system was evaluated by using different experimental models such as carbon clearance test, cyclophosphamide induced neutropenia, neutrophil adhesion test, effect on serum immunoglobulins, mice lethality test and indirect haemagglutination tes ... | 2010 | 20067869 |
| postprandial hypoglycemic effect of mulberry leaf in goto-kakizaki rats and counterpart control wistar rats. | postprandial hypoglycemic effect of mulberry leaf (morus alba l.) was compared in two animal models: goto-kakizaki (gk) rats, a spontaneous non-obese animal model for type ii diabetes, and their counterpart control wistar rats. first, the effect of a single oral administration of mulberry leaf aqueous extract (mle) on postprandial glucose responses was determined using maltose or glucose as substrate. with maltose-loading, mle reduced peak responses of blood glucose significantly in both gk and ... | 2009 | 20098579 |
| four new 2-arylbenzofuran derivatives from leaves of morus alba l. | four new 2-arylbenzofuran derivatives, moracins v-y (1-4), together with two known compounds, moracin n (5) and moracin p (6), were isolated from the leaves of morus alba l. their structures were elucidated by spectroscopic analysis. moracins x (3) and y (4) represent unusual substituted group compared with 2-arylbenzofuran derivatives, which were isolated from the genus morus. compounds 2-5 were evaluated for cytotoxicity against several human cancer cell lines. | 2010 | 20118592 |
| mulberry fruit protects dopaminergic neurons in toxin-induced parkinson's disease models. | parkinson's disease (pd), one of the most common neurodegenerative disorders, is characterised by the loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) to the striatum (st), and involves oxidative stress. mulberry fruit from morus alba l. (moraceae) is commonly eaten, and has long been used in traditional oriental medicine. it contains well-known antioxidant agents such as anthocyanins. the present study examined the protective effects of 70 % ethanol extract of mulberry ... | 2010 | 20187987 |
| cytotoxic activities of several geranyl-substituted flavanones. | nine geranylated flavanones isolated from the fruits of paulownia tomentosa (4-12) and two from the roots of morus alba (13 and 14) were examined for cytotoxicity to selected human cancer cell lines and normal human fibroblasts. cytotoxicity was determined in vitro using a calcein am cytotoxicity assay. cytotoxicity for the thp-1 monocytic leukemia cell line was tested using erythrosin b cell staining. the geranylated compounds tested were compared with the known simple flavanone standards taxif ... | 2010 | 20192247 |
| two new chalcones from leaves of morus alba l. | two new chalcone derivatives named morachalcones b and c (1 and 2) were isolated from the leaves of morus alba l. their structures were elucidated by spectroscopic analysis. morachalcones b (1) and c (2) represent two examples of chalcones having unusual furan rings which are formed by cyclization between c-alpha-oh and c-2-oh. compounds 1 and 2 displayed only moderate cytotoxic activity against hct-8 and bgc823 human cancer cell lines. | 2010 | 20211228 |
| adaptogenic effect of morus alba on chronic footshock-induced stress in rats. | the objective of the present study was to evaluate the adaptogenic property of the ethyl acetate-soluble fraction of methanol extract of morus alba roots against a rat model of chronic stress (cs). | 2009 | 20407553 |
| albanol a from the root bark of morus alba l. induces apoptotic cell death in hl60 human leukemia cell line. | albanol a (1), isolated from the root bark extract of morus alba (mulberry), was evaluated for the cytotoxic and apoptosis-inducing activities in human leukemia (hl60) cells, and for the inhibitory activity in human dna topoisomerases (topo) i and ii. this compound showed potent cytotoxic activity (ic(50) 1.7 microm) on the cells, and potent inhibitory activity on topoisomerase ii (ic(50) 22.8 microm). in addition, albanol a induced early apoptosis which was detected by observing the membrane ph ... | 2010 | 20410645 |
| identification of bet v 1-related allergens in fig and other moraceae fruits. | allergy to fig fruit (ficus carica) has been described in patients allergic to ficus benjamina or rubber latex but may occur also in pollen-allergic patients. | 2010 | 20447079 |
| hypolipidemic and antioxidant effects of mulberry (morus alba l.) fruit in hyperlipidaemia rats. | the phytochemical constituents of a freeze-dried powder of mulberry (morus alba l.) fruit (mfp) were determined. the hypolipidemic and antioxidant effects of the mfp as a dietary supplement were evaluated in rats who were fed 4 weeks of either a high-fat or a normal diet supplemented with 5% or 10% mfp. administration of mfp to rats on a high-fat diet resulted in a significant decline in levels of serum and liver triglyceride, total cholesterol, serum low-density lipoprotein cholesterol, and a d ... | 2010 | 20561945 |