| new plasmid-mediated oxacillin-hydrolyzing beta-lactamase in pseudomonas aeruginosa. | a novel type of oxacillin-hydrolyzing beta-lactamase, termed oxa-4, has been detected in three pseudomonas aeruginosa strains isolated in paris between 1977 and 1981. the strains contained similar plasmids that determined resistance to carbenicillin, chloramphenicol, gentamicin, kanamycin, streptomycin, sulphonamide, tetracycline, tobramycin, sodium borate, and mercuric chloride, had a size of approximately 150 megadaltons, and belonged to the p-5 incompatibility group. compared to reference oxa ... | 1986 | 3086272 |
| transposition of the oxacillin-hydrolyzing penicillinase gene. | we have found that the oxacillin-hydrolyzing penicillinase gene (oxa) encoded by plasmid rgn238 transposes to various plasmids in a reca background. we call this transposable element tn2603. tn2603 encodes the genes for streptomycin, sulfonamide, and mercury resistance in addition to the oxa gene. tn2603 has a molecular size of 19.6 kilobase pairs and appears to be flanked by small inverted repeat sequences of about 200 base pairs long. | 1981 | 6257651 |
| characterization of integrons in escherichia coli of the normal intestinal flora of swine. | multiresistant escherichia coli isolates of the normal intestinal flora of healthy fattening pigs were examined for the presence of integron class 1 by xl (extra long) pcr. the class 1 integron was detected in 17 isolates originating from 14 healthy animals on seven different farms. one isolate contained two class 1 integrons. the inserted gene cassettes were characterized by dna sequencing and pcr. the ant(3")-ia gene responsible for resistance to streptomycin/spectinomycin was inserted in all ... | 1999 | 10647086 |
| precise insertion of antibiotic resistance determinants into tn21-like transposons: nucleotide sequence of the oxa-1 beta-lactamase gene. | several plasmid-encoded beta-lactamases are on multiresistance transposable elements. the oxa-1 beta-lactamase gene is part of tn2603, which is borne on the r plasmid rgn238. we report here the complete nucleotide sequence of the oxa-1 beta-lactamase gene and flanking sequences. the oxa-1 gene shows a greater than 50% sequence divergence from the oxa-2 gene, yet there is significant functional similarity at the peptide level. analysis of 5' and 3' flanking sequences shows that tn2603 differs fro ... | 1987 | 2823258 |