| the chloramphenicol acetyltransferase gene of tn2424: a new breed of cat. | we have sequenced the gene coding for the chloramphenicol acetyltransferase of tn2424 of plasmid nr79. this gene codes for a protein of 23,500 da, and the derived protein sequence is similar to those of the chromosomal chloramphenicol acetyltransferases of agrobacterium tumefaciens and pseudomonas aeruginosa and of unidentified open reading frames, which may encode chloramphenicol acetyltransferases, adjacent to the ermg macrolide-lincosamide-streptogramin resistance gene of bacillus sphaericus ... | 1992 | 1314803 |
| amikacin resistance mediated by multiresistance transposon tn2424. | tn2424, a multiresistance transposon 25 kilobases long, was isolated from incfii plasmid nr79. tn2424 transposed resistance to sulfonamides, streptomycin and spectinomycin, mercuric chloride, chloramphenicol, and amikacin with a frequency of 6 x 10(-5). resistance to amikacin was mediated by a 6'-n-acetyltransferase, which conferred higher levels of resistance in pseudomonas aeruginosa than in escherichia coli. a restriction analysis and cloning experiments resulted in a physical and functional ... | 1983 | 6307980 |