| mycobacterium ulcerans infection: treatment with rifampin, hyperbaric oxygenation, and heat. | the effectiveness of hyperbaric oxygenation (hbo), heat, and rifampin for treating mice infected with mycobacterium ulcerans was analyzed. four hundred mice were innouclated in the hind footpads with 10(8) organisms. the seven treatment groups (50 mice each) were hbo (2.5 ata for 1.5 h, twice a day), rifampin (rif) (20 mg/kg body weight/d), heat (mice maintained at 37 degrees c), and all combinations of the three treatments. the severity of infection in the treated mice was compared weekly for 2 ... | 1979 | 496758 |
| [dermatology in french guiana]. | in french guayana, climatic and geographic conditions enhance development of numerous fungal, parasitic and microbial skin diseases. the most particular infectious diseases of this french department are lobomycosis, chromomycosis (phialophora pedrosoi), creeping disease, cutaneous leishmaniasis, tungiasis, mycobacterial ulcus (mycobacterium ulcerans) and papular dermatitis caused by nettling hairs of lepidoptera (hylesia urticans). the occurence of these skin diseases is demonstrative of patholo ... | 1979 | 511550 |
| studies on exocellular substances of mycobacterium ulcerans. i. preliminary report on a susceptible animal to the substances. | | 1978 | 754409 |
| preliminary evidence for the trapping of antigen-specific lymphocytes in the lymphoid tissue of 'anergic' tuberculosis patients. | lymphocyte-transformation responses to mycobacterial antigens have been studied, using paired blood and lymph node samples from 'normal' ugandans, (hernia repairs or orthopaedic cases) or from patients with tuberculosis, mycobacterium ulcerans infection, or injection abscesses. the results suggest that in some individuals, antigen reactive cells, although absent from the periphery, may be demonstrable in the lymph nodes. this phenomenon is most striking in skin-test negative tuberculosis patient ... | 1976 | 826362 |
| the protective effect of bcg against mycobacterium ulcerans disease: a controlled trial in an endemic area of uganda. | in a bcg vaccination trial in an area of uganda endemic for mycobacterium ulcerans disease ("buruli ulcer"), 8,856 persons were examined for the disease in mid-1970 and tuberculin tested; bcg was given by intradermal injection to a random 50% of all those with negative, low or middle grade tuberculin reactions; twelve months later the study group was re-examined for m. ulcerans lesions and, subsequently, new cases of the disease were detected, using a hospital registration system, to december 19 ... | 1976 | 841647 |
| experimental alimentary infection of anole lizards (anolis carolinensis) with mycobacterium ulcerans. | pathogenic mycobacterium ulcerans were recovered from the stool of anole lizards up to 11 days after inoculation by stomach tube. m. ulcerans was isolated from the liver of 3 of 20 lizards and acid fast bacteria were seen in the mucosa of intrahepatic bile ducts in 2 of these 10 weeks post-inoculation. these results provide equivocal support for our hypothesis that herpetofauna are a reservoir of infection with m. ulcerans. | 1976 | 961984 |
| the production and preliminary investigation of burulin, a new skin test reagent for mycobacterium ulcerans infection. | the preparation of a skin test antigen from mycobacterium ulcerans by ultrasonic disintegration and filtration is described. the reagent, called burulin, was tested in africa in normal school children, and in patients with leprosy, tuberculosis or m. ulcerans disease. those with tuberculosis or m. ulcerans disease were simultaneously tested with tuberculin ppd. burulin was found to be highly specific for patients in the reactive stage of m. ulcerans disease, and there was no cross-reaction in pa ... | 1975 | 1054061 |
| mycobacterium ulcerans in australia. | the epidemiology of 39 case reports of infection with mycobacterium ulcerans published during the past 25 years in australia is presented. a review is made of the laboratory findings of the strains found in australia and of the contribution of australian workers to the description, treatment and prevention of this disfiguring disease. | 1975 | 1057928 |
| the potentiating, mitogenic and inhibitory effects on lymphocytes in vitro, of macrophages in the lymph nodes of mice 'overloaded' with mycobacterial products. | the lymph nodes of mice overloaded with mycobacterial products, either by the injection of whole or ultrasonicated organisms, or as a consequence of severe infection with mycobacterium ulcerans, contain phagocytic cells which cause spontaneous transformation of the lymph node cells in a low volume, high cell density culture system. this spontaneous mitosis is unaffected by trypsinization but is inhibited by specific antigen and by pha, and eliminated by treatment with carbonyl iron. replacement ... | 1975 | 1081020 |
| mycobacterium ulcerans infections in leprosy patients. | | 1975 | 1152576 |
| activity of rifampicin on mycobacterium ulcerans. | | 1975 | 1164050 |
| treatment of mycobacterium ulcerans infection by hyperbaric oxygenation. | mycobacterium ulcerans causes chronic nectotizing ulcers of the skin and subcutaneous tissue and is a serious health problem in some tropical countries. chemotherapy has not been effective, and the treatment of choice is extensive debridement followed by skin grafting. in spite of this, many infections are complicated by disfiguring scars, contraction deformities, and--rarely--amputation. there are other procedures that may promote healing (e.g., heat treatment, rifampicin), but none has been co ... | 1975 | 1180783 |
| editorial: mycobacterium ulcerans in australia. | | 1975 | 1207547 |
| letter: mycobacterium ulcerans in australia. | | 1975 | 1219345 |
| absence of an antibiotic effect of mycobacterium ulcerans. | fractions of mycobacterium ulcerans were tested for the ability to inhibit growth of 39 bacterial strains. at protein concentrations of up to 280 mg/ml, there was no detectable effect on the growth of any of these bacterial strains. | 1975 | 1240875 |
| [cutaneous ulcer from mycobacterium ulcerans. apropos of 1 case in french guiana]. | skin ulcer due to mycobacterium ulcerans is presented. the patient come from east of french guyana. growth of this mycobacteria is obtained with diphasic lowenstein medium at 30 degrees c. diagnostic of m. ulcerans results from mycolic acids study. | 1992 | 1422270 |
| the phenolic mycoside of mycobacterium ulcerans: structure and taxonomic implications. | mycobacterium ulcerans and some pathogenic mycobacterial species elaborate wax a consisting of related long-chain beta-diol components (phthiocerol and related compounds) esterified by multimethyl-branched fatty acids. with the exception of m. ulcerans, wax a-containing mycobacteria also synthesize glycosylated phenol phthiocerol diester and related compounds: the so-called phenolic mycosides. in a deliberate effort to characterize this latter class of compounds in m. ulcerans, 20 strains were e ... | 1992 | 1556545 |
| mycobacterium ulcerans infection. | | 1991 | 1670719 |
| postulated epidemiology of mycobacterium ulcerans infection. | mycobacterium ulcerans infection occurs in closely defined areas throughout the world, mostly in the tropics. whenever it occurs there is a relationship with rain forest and this relationship is apparent in gippsland, australia which is not tropical but which contains isolated pockets of relict warm temperate rain forest. human infection follows rain forest disturbance; it is postulated that the mycobacterium is carried into draining lacustrine systems where it multiplies over a period of months ... | 1991 | 1800409 |
| mycobacterium ulcerans infection in paradise. | | 1991 | 1857294 |
| buruli ulcer in benin. | in a study of 28 patients with mycobacterium ulcerans infection (buruli ulcer) in oinhi, benin, it became clear that the disease can regress as well as progress, and that patients can have lesions of different stages simultaneously. a system of disease staging was introduced (i = subcutaneous nodule; ii = cellulitis; iii = ulceration; iv = scar formation). research to find an effective treatment for this crippling disease is urgently needed. | 1990 | 1977990 |
| characteristic new members of the phthiocerol and phenolphthiocerol families from mycobacterium ulcerans. | diacyl phthiodiolone a and phenolphthiodiolone a lipids were isolated from two strains of mycobacterium ulcerans. the diol units of the phthiodiolone a and phenolphthiodiolone a components were shown to have erythro stereochemistry by infrared spectroscopy and proton nuclear magnetic resonance of an acetal derivative. this stereochemistry is shared only by related diols from m. marinum, the diols from m. bovis, m. kansasii, m. leprae and m. tuberculosis having threo stereochemistry. | 1990 | 2323535 |
| treatment of cutaneous infection due to mycobacterium ulcerans. | a zairese patient with an extensive ulceration on the left foot due to mycobacterium ulcerans was successfully treated with antibiotics and debrisan. the diagnosis and treatment are discussed. | 1985 | 2416603 |
| mycobacterium ulcerans infections in papua new guinea: correlation of clinical, histological, and microbiologic features. | biopsy material from 46 cases clinically diagnosed as mycobacterium ulcerans infection was studied. the disease was found to be most frequent in east sepik province, and in the first decade of life. in these 46 cases the histological features were characteristic and acid-fast bacilli were seen in tissue sections. | 1988 | 2451445 |
| comparative studies of antigenic glycolipids of mycobacteria related to the leprosy bacillus. | the leprosy bacillus, mycobacterium leprae, is a member of a small group of mycobacteria comprising the species mycobacterium bovis, mycobacterium marinum, mycobacterium kansasii, mycobacterium tuberculosis, mycobacterium ulcerans and related taxa. this relationship is based on the similarity of the characteristic lipid types in the cell envelope. mycobacterium leprae produces a phenolic glycolipid antigen which is species specific. this communication reports a comparison of the specificity of t ... | 1989 | 2504005 |
| detection of phthiocerol derivatives in mycobacterium ulcerans: a preliminary report. | | 1989 | 2504008 |
| mycobacterium ulcerans infection in ashanti region, ghana. | we describe a series of 96 cases of mycobacterium ulcerans infection (buruli ulcer) from a new endemic focus in the afram valley, north of agogo, in ghana. 63 cases were children under 13 years old. active treatment by excision and skin grafting necessitates long stays in hospital and repeated procedures. scarring and contracture are frequent. eyes and other vital organs may be destroyed. in its endemic foci buruli ulcer is a serious health burden on rural populations. research is urgently neede ... | 1989 | 2617591 |
| [epidemiology of ulcers due to mycobacterium ulcerans]. | | 1989 | 2679452 |
| immunosuppressive properties of the soluble toxin from mycobacterium ulcerans. | | 1988 | 2963867 |
| [infections due to mycobacterium ulcerans and mycobacterium haemophilum]. | | 1988 | 3050243 |
| infection and disease due to the environmental mycobacteria. | saprophytic mycobacteria are widely distributed in the environment and contact between them and man is unavoidable. immunologically effective contact is responsible for cross-reactivity to tuberculin and there is increasing evidence that it also profoundly affects the nature of subsequent responses to bcg vaccination and to infection by the tubercle and leprosy bacilli. some environmental mycobacteria occasionally cause overt disease. two species, mycobacterium ulcerans and m. marinum, cause cha ... | 1987 | 3303476 |
| unexpected findings amongst the skin test responses to mycobacteria of bcg vaccinated kuwaiti school children. | a multiple skin test survey was carried out in kuwait on 1200 school children aged 8-11 years, and on 1228 children aged 12-16 years. with only 15 exceptions, all these children had received vaccination with japanese bcg just before they started school, 5 years and 9 years earlier respectively. tuberculin positivity was almost 90% in both groups, with a mean response size of 8.7 mm. this was associated with remarkably high responsiveness to many of the other mycobacterial species investigated. s ... | 1987 | 3310346 |
| mycobacterium ulcerans infection in victoria: celebration of a golden jubilee? | | 1987 | 3504150 |
| suspected mycobacterium ulcerans disease in kiribati. | two cases of extensive limb ulcers that had the clinical features of mycobacterium ulcerans infection are described. this condition has not been described previously in the central pacific region. both patients responded to radical debridement and skin grafting. | 1987 | 3614046 |
| [buruli ulcer--necrotizing infection of the hand of a plastic surgeon]. | the buruli ulcer is caused by mycobacterium ulcerans. the clinical features of this atypical mycobacteriosis are similar to tuberculosis. differentiation is only possible by microbiological investigation. in cases of chronic soft tissue infections mycobacteriosis must be taken into consideration. since microbiological differentiation needs 8-12 weeks and chemotherapy is not effective, early and wide surgical excision is the treatment of choice. | 1987 | 3623277 |
| epidemiology of mycobacterium ulcerans infection in koalas (phascolarctos cinereus) on raymond island, southeastern australia. | mycobacterium ulcerans infections were found in 11 koalas (phascolarctos cinereus) between 1980 and 1985, in a population of approximately 200 koalas on raymond island in southeastern australia. ulcers caused by the infection occurred on the face, forearm, rump, groin and footpads. seven koalas had multiple ulcers. all the infected animals were mature (age classes 4, 5 and 6), and eight were male. the distribution of ulcers corresponded with the distribution of wounds in a sample of 87 koalas. m ... | 1987 | 3625894 |
| suspected mycobacterium ulcerans disease in kiribati. | | 1987 | 3670177 |
| cutaneous and respiratory tract infection with mycobacterium ulcerans in two koalas (phascolarctos cinereus). | | 1985 | 3999251 |
| influence of genes of the major histocompatibility complex on ulcerative dermal necrosis induced in mice by mycoplasma arthritidis. | all mouse strains injected s.c. with mycoplasma arthritidis developed severe abscesses in the subdermal tissues. however, m. arthritidis strain 14124 p10 also induced an ulcerative dermal coagulation necrosis in mouse strains expressing the k and d haplotypes but not in those expressing the b, q, or s haplotypes. the use of inbred and congenic mouse strains established that the ulcerative necrosis was associated with the haplotypes expressed at the h2 major histocompatibility complex (mhc). the ... | 1985 | 4045222 |
| mycobacterium fortuitum (tmc 1529): potentially immunogenic strain against experimental infections of mycobacterium ulcerans in rats and mice. | | 1985 | 4077138 |
| clinical features of mycobacterium ulcerans infection. | | 1985 | 4084161 |
| the pathology of mycobacterium ulcerans infection. | the pathology of cutaneous ulcers resulting from mycobacterium ulcerans infection is reviewed. initial infection causes ulceration with necrosis of the dermis and a septate panniculitis in subcutaneous fat. there is little cellular reaction despite the presence of large numbers of organisms. recurrent or persistent infection produces a granulomatous reaction with epithelioid macrophages, variable numbers of giant cells of the langhans type, and relatively few organisms. this type of reaction is ... | 1985 | 4094789 |
| a controlled trial of the treatment of mycobacterium ulcerans infection with clofazimine. | | 1973 | 4126917 |
| bcg vaccination against mycobacterium ulcerans infection (buruli ulcer). first results of a trial in uganda. | | 1969 | 4178240 |
| an immunodiffusion analysis of strains of mycobacterium ulcerans isolated in australia, malaya, mexico, uganda and zaire. | | 1973 | 4199273 |
| the use of surgery and local temperature elevation in mycobacterium ulcerans infection. | | 1972 | 4260207 |
| human mycobacterium ulcerans infections developing at sites of trauma to skin. | in zaire, we studied 180 patients with mycobacterium ulcerans infections and found 14 with a history of antecedent trauma at the site of the lesion (e.g., gunshot and land mine injuries, penetrating wood splinters, and scorpion stings). two patients developed lesions following hypodermic injections. we believe that trauma is an important mode of transmitting m. ulcerans infections, or of introducing the etiologic agent into the dermis of subcutaneous tissue from superficially contaminated skin. | 1974 | 4451232 |
| heat treatment of mycobacterium ulcerans infections without surgical excision. | eight patients from zaire with mycobacterium ulcerans infection were treated by the local application of heat to maintain a temperature of approximately 40 degrees c in the ulcerated area. all lesions healed without surgical intervention and without local recurrences during follow-up periods of up to 22 months. this study shows that local heat promotes healing of m. ulcerans lesions. we postulate that the mechanism is primarily by direct inhibition of multiplication of m. ulcerans. other possibl ... | 1974 | 4451233 |
| notes on mycobacterium ulcerans. | | 1972 | 4502764 |
| [mycobacterium ulcerans infection in man (baruli-ulcer)]. | | 1973 | 4594782 |
| the primary isolation of mycobacterium ulcerans. | | 1973 | 4702687 |
| mycobacterium ulcerans infection among tsetse control workers in uganda. | | 1973 | 4777772 |
| letter: the nomenclature of mycobacterium ulcerans infections. | | 1973 | 4788772 |
| epidemiology of mycobacterium ulcerans infection. | | 1973 | 4798218 |
| opportunistic cutaneous mycobacterium marinum infection mimicking mycobacterium ulcerans in lymphosarcoma. | | 1973 | 4800424 |
| cytotoxic activity of mycobacterium ulcerans. | although mycobacterium ulcerans elicits extensive necrosis of human skin and subcutaneous tissue, the specific cause of the necrosis has never been elucidated. in an attempt to define a toxic substance, 18 strains of m. ulcerans were inoculated into mice, and the progress of each infection was observed and compared with infections of other mycobacteria, including m. cheloni, m. marinum, and m. bovis. culture filtrates and viable organisms of each of these mycobacteria were inoculated onto tissue ... | 1974 | 4830529 |
| distribution of mycobacterium ulcerans infections in zaire, including the report of new foci. | | 1974 | 4841554 |
| rifampicin in experimental mycobacterium ulcerans infection. | | 1972 | 5022508 |
| epidemiology of mycobacterium ulcerans infection (buruli ulcer) at kinyara, uganda. | | 1971 | 5157438 |
| mycobacterium ulcerans infection (with comments on pathogenesis). | | 1965 | 5322711 |
| mycobacterium ulcerans infection: a report of 13 cases at the port moresby general hospital, papua. | | 1967 | 5336860 |
| [an ulcer caused by mycobacterium ulcerans]. | | 1969 | 5368310 |
| clinical features and treatment of pre-ulcerative buruli lesions (mycobacterium ulcerans infection). report ii of the uganda buruli group. | at kinyara, and in other areas of uganda, 250 patients with pre-ulcerative buruli lesions (myco. ulcerans infection, have been seen over the past three years. the clinical feature of the pre-ulcerative stage of the disease are painless nodules, usually occurring singly on the legs or forearms. as the nodule can grow rapidly to become an extensive fulminating lesion, early recognition of the nodule and an appreciation of its significance by both doctor and patient are essential. excision of the n ... | 1970 | 5420605 |
| [mycobacterium ulcerans infection. symptoms, differential diagnostic and treatment]. | | 1970 | 5518191 |
| [bacteriology and human and experimental pathology of ulcers caused by mycobacterium ulcerans]. | | 1965 | 5829986 |
| mycobacterium ulcerans infection. clinical and bacteriological study of the first cases recognized in south east asia. | | 1966 | 5910904 |
| mycobacterium ulcerans in liberia: a clinicopathologic study of 6 patients with buruli ulcer. | two patients with buruli ulcer (infection by mycobacterium ulcerans) in the foya region of liberia have recently been reported. we describe three more patients which together with the two original patients establish the mayor river basin as an endemic area of buruli ulcer. we also describe a patient from the st. paul river basin. this disease, unrecognized in liberia before 1978, now seems to be widespread in liberia and has been reported in neighboring sierra leone and observed in ivory coast a ... | 1984 | 6147988 |
| mycobacterium ulcerans: an infection from jurassic time? | | 1984 | 6149397 |
| skin ulcers caused by mycobacterium ulcerans in koalas near bairnsdale, australia. | skin ulcers were found in 7 koalas from raymond island in the gippsland lakes of southeastern australia. ulcers in 4 koalas showed loss and underrunning of cutaneous tissue, with coagulative necrosis of subcutaneous tissue. these lesions contained large numbers of acid-fast bacilli, and areas of granulation tissue formation and superficial inflammation were present. mycobacterium ulcerans was isolated from 2 of these animals. the ulcers from the other 3 koalas contained both m. ulcerans and m. s ... | 1984 | 6514393 |
| [specific lipids from mycobacterium ulcerans]. | the main lipids synthesized by mycobacterium ulcerans are specific for the species. three products were isolated by chromatography. their structures were determined by means of spectrographic methods performed on the natural substances or on their split products. the most abundant products were phthiodiolone diphthioceranate and phenolphthiodiolone diphthioceranate . these structures have some analogies with those of phthiocerol dimycocerosate synthesized by m. tuberculosis and m. bovis, and wit ... | 1984 | 6721323 |
| [a case of typical mycobacteriosis due to mycobacterium ulcerans-like organism (author's transl)]. | | 1982 | 6981005 |
| mycobacterium ulcerans infection across lake victoria. | | 1982 | 7132854 |
| mycobacterium ulcerans. infection of two patients in liberia. | | 1981 | 7239752 |
| radiological abnormalities of the ileum associated with the use of clofazimine (lamprene; b663) in the treatment of skin ulceration due to mycobacterium ulcerans. | | 1980 | 7442414 |
| molecular method for typing mycobacterium ulcerans. | a cluster of mycobacterium ulcerans infections has recently occurred on phillip island, victoria, australia. previous cases of infection have generally been located around bairnsdale in southeast gippsland. the aim of this study was to determine the epidemiological relationship between these strains and other strains originating in australia and africa. the previously described plasmid ptbn12 was used as a probe with restriction enzyme-digested chromosomal dna to differentiate the strains of m. ... | 1995 | 7494010 |
| emergence of buruli ulcer disease in the daloa region of cote d'ivoire. | recent reports have suggested increases in buruli ulcer (bu), an infection caused by mycobacterium ulcerans in west africa. in 1991, we conducted surveillance for bu in a rural area of cote d'ivoire and identified 312 cases of active or healed ulceration. a case-control study was then performed to investigate risk factors for this infection. the rate of illness did not appear to differ between males and females (5.2% versus 7.5%; p = 0.11). the highest rate of illness was seen in the 10-14-year- ... | 1995 | 7694962 |
| [buruli ulcer in a zairian woman with hiv infection]. | isolated cutaneous mycobacterial infection is exceptional in the acquired immunodeficiency syndrome (aids). we report a case of buruli ulcer observed in a zairan female infected with the human immunodeficiency virus (hiv). | 1994 | 7755313 |
| [dermatological aspects of aids in western africa. apropos of 140 cases]. | this clinical survey, carried out during a 3 years period in the dermatological department of bouake hospital (ivory coast) analyses the skin and mucous membranes troubles caused by aids among adults. it is the first of that kind in western africa. 140 patients were concerned, showing carious dermatological troubles, 25 of them were counted. few tropical skin diseases have their clinical picture altered by immunodeficiency. however, the buruli ulcer may be described, which has in this condition ... | 1994 | 7827518 |
| mycobacterium ulcerans infection on phillip island, victoria. | | 1995 | 7877550 |
| [therapeutic approach in mycobacterium ulcerans infections]. | in côte d'ivoire, 88 patients of a series of 124 cases with buruli ulcer have been able to be treated and supervised. all of them have received local cares and various antibiotics, and 23 have been treated by islet skin graft. among the numerous antibiotics used, only streptomycin seems to be accompanied by an acceptable failure rate. the islet-graft presents the advantage of the technical simplicity, of the good tolerance face the infection and of a good successful rate, which permits to shorte ... | 1994 | 8003899 |
| cotrimoxazol in the treatment of mycobacterium ulcerans infection (buruli ulcer) in west africa. | | 1994 | 8009616 |
| mycobacterium ulcerans associated with infection due to the human immunodeficiency virus. | | 1994 | 8075291 |
| identification of the leprosy bacillus and related mycobacteria by analysis of mycocerosate profiles. | members of the phthiocerol dimycocerosate family of waxes were extracted from mycobacterium bovis bcg, mycobacterium tuberculosis, mycobacterium kansasii, mycobacterium marinum, mycobacterium ulcerans and a skin biopsy from a leprosy patient. the waxes were degraded by alkaline hydrolysis and the mycocerosic acids converted to pentafluorobenzyl ester. profiles of the esters, recorded using electron-capture gas-chromatography, gave characteristic profiles for the mycocerosates from m. leprae but ... | 1993 | 8129476 |
| [epidemiological and clinical aspects of buruli ulcer in ivory coast. 124 recent cases]. | a prospective study during 28 months at the regional hospital center of bouake (ivory coast) allows to gather 124 cases of buruli ulcer. today, this atypical cutaneous mycobacteriosis is in full expansion in west africa. the pathogen agent, mycobacterium ulcerans, causes, by its toxin, a subcutaneous necrosis often extended, followed by an ulceration which clinical characteristics are sufficient for the diagnostic. the endemic progression reason may not be caused by the modification of patients ... | 1993 | 8292919 |
| mycobacterium ulcerans infection on phillip island, victoria. | | 1994 | 8295586 |
| mycobacterium ulcerans and osteomyelitis. | | 1993 | 8336765 |
| mycobacterium ulcerans and osteomyelitis. | | 1993 | 8380028 |
| out of africa: observations on the histopathology of mycobacterium ulcerans infection. | | 1993 | 8432888 |
| the emergence of mycobacterium ulcerans infection near melbourne. | to document the emergence of new foci of mycobacterium ulcerans infection (bairnsdale ulcer) in victoria. | 1996 | 8569576 |
| mycobacterium ulcerans infection in australian children: report of eight cases and review. | in the past 25 years, eight patients with presumed or proven mycobacterium ulcerans infection have been treated at the royal children's hospital, melbourne, australia. at least four of these patients had recently been in southeastern victoria, australia, a temperate region where the disease was first described and where sporadic infection occurs. nonspecific clinical manifestations and an indolent course often lead to delayed diagnosis. surgical excision is the mainstay of treatment and was used ... | 1995 | 8589141 |
| mycobacterium ulcerans infection (buruli ulcer): first reported patients in togo. | mycobacterium ulcerans infection (buruli ulcer) is the third most common mycobacterial infection of immunocompetent humans, and is an emerging disease in west africa. we describe the first two reported patients with buruli ulcer in togo, establishing a geographical continuum of the disease in all countries bordering the gulf of guinea. the aetiological agent was identified by molecular biological analysis of biopsy material. we speculate that changing environmental factors related to human habit ... | 1996 | 8763437 |
| assessment of genetic markers for species differentiation within the mycobacterium tuberculosis complex. | it is important to correctly identify species within the mycobacterium tuberculosis complex because of the zoonotic implications of bovine tuberculosis, especially in developing countries. we assessed the use of various genetic markers for species-specific identification of mycobacteria from the m. tuberculosis complex. a multiplex pcr designed for detection of the mtp40 and is1081 elements was optimized and evaluated in 339 mycobacterial strains from different animal and geographic origins. the ... | 1996 | 8815111 |
| variability in 3' end of 16s rrna sequence of mycobacterium ulcerans is related to geographic origin of isolates. | mycobacterium ulcerans causes extensive ulcers (buruli ulcers) in the skin of humans. analysis of the 3'-terminal region of the 16s rrna gene sequence of 17 strains of m. ulcerans from africa, the americas, and australia revealed three subgroups corresponding to the continent of origin, and some variable phenotypic characteristics. this sequence is useful for the rapid detection of m. ulcerans and discriminates m. marinum and m. shinshuense from m. ulcerans. | 1996 | 8815117 |
| [mycobacterium ulcerans cutaneous infections: buruli ulcers]. | mycobacterium ulcerans skin infection or buruli ulcers are common in children in many rural tropical areas. the usual clinical appearance is a deep, rapidly developing chronic ulcer associated with necrosis of subcutaneous fat. patients are usually seen at an advanced stage. bacteriologic identification is not always possible because the pathogen, mycobacterium ulcerans, is an atypical mycobacteria that is difficult to isolate and grows slowly in culture. medium although of little assistance in ... | 1995 | 8830223 |
| identification and characterisation of a superoxide dismutase and catalase from mycobacterium ulcerans. | previous investigations have demonstrated the presence of both superoxide dismutase and catalase enzymes in several intracellular pathogens, including a number of mycobacterial species. these enzymes are believed to be involved in the protection of the pathogen from the bactericidal products of oxidative metabolism. superoxide dismutase and catalase were identified in crude extracts of mycobacterium ulcerans by polyacrylamide gel electrophoresis. inhibition experiments showed that the superoxide ... | 1996 | 8918957 |
| evidence against the involvement of mycobacterium ulcerans in most cases of necrotic arachnidism. | cutaneous lesions caused by m. ulcerans were shown to bear only a superficial resemblance to those produced by certain spider species. m. ulcerans was not found in either the venoms or the midguts of several australian spiders, and deliberate contamination by inoculation of the fangs and digestive system of the wolf spider, lycosa godeffroyi, did not result in permanent colonization. m. ulcerans was successfully introduced into the skin of mice through a small trauma site similar to that caused ... | 1995 | 7603753 |
| mycobacterium ulcerans osteomyelitis: a closer look at the x-ray films. | | 1996 | 8965889 |
| mycobacterium ulcerans skin infection in a patient with hiv infection: is this incidental? | | 1997 | 9030030 |
| [mycobacterium ulcerans skin ulcers (or buruli ulcers) (author's transl)]. | | 1980 | 7212557 |
| mastomys natalensis: a new animal model for mycobacterium ulcerans research. | | 1984 | 6510972 |