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antimicrobial effects of some bis-biguanides on certain bacteria which occur in connection with acne vulgaris. 19766710
the bacteriology of skin cysts.thirty-nine clinically uninflamed cysts of the three most common varieties, epidermoid cysts, trichilemmal cysts and steatocystoma multiplex were removed under sterile conditions and the contents cultured under aerobic and anaerobic conditions. seventy-three percent of epidermoid cysts grew significant numbers of organisms whereas none of the trichilemmal cysts did so. the organisms found were the common skin commensals, staphylococcus epidermidis biotype i, anaerobic gram positive cocci of the ...197717428
mechanism of inhibition of immunization with irradiated tumour cells by a large dose of corynebacterium parvum. 197718742
bacteriocin-like activities of human dental plaque flora against oral anaerobic microorganisms. 197726477
the role of bacteria in acne vulgaris: a new approach. 197832979
complement activation by propionibacterium acnes and bacteroides melaninogenicus. 197833641
intergeneric and intrageneric inhibition between strains of propionibacterium acnes and micrococcaceae, particularly staphylococcus epidermidis, isolated from normal skin and acne lesions.two hundred and forty-one strains or resident skin bacteria comprising 93 isolates of propionob acterium acnes and 148 of micrococcaceae derived from 36 acne patients and 8 control subjects were screened for their ability to inhibit 32 indicator strains, including 20 strains of p. acnes and 12 strains of staphylococcus epidermidis derived from patients with all grades of acne and from normal skin. fifty-three strains (22%) showed some activity against at least one indicator strain. both broad- a ...197934728
[the bacterial flora of preputial space].the bacterial flora of the preputial space of 210 healthy males (43 children aged between 2 and 11 years, 137 males between 12 and 60 years and 30 men over 60 years) was determined by smears and cultueres from glans penis, sulcus coronarius and the adjacent prepuce. the results were grouped according to various criteria, e.g. glans covered or uncovered and age of males. differences in the distribution of germs could be found in relationship to age. in the case of an uncovered glans penis the pre ...197935486
purification and partial characterization of hyaluronate lyase (ec 4.2.2.1) from propionibacterium acnes.hyaluronidase from propionibacterium acnes has been purified 13,000-fold from the culture supernatant to homogeneity (as determined by polyacrylamide disc gel electrophoresis). the molecular weight of the purified enzyme was 85,110 as determined by gel filtration. the purified enzyme had a ph optimum at 6.4, was stable between ph 5 and 5.8 and was completely inactivated after 15 min at 50 degrees c. preliminary studies suggested that the enzyme is active against chondroitin 4- and 6-sulphates, b ...197943356
production of hyaluronidase by propionibacteria from different origins.114 strains of anaerobic and microaerophilic coryneform bacteria from different origins were investigated for production of free extracellular hyaluronidase (hyaluronate glycanohydrolase, ec 3.2.1.36). a quantitative technique was applied measuring the release of n-acetyl-glucosamine groups from purified human potassium hyaluronate. the strains belonged to the following species: propionibacterium acnes, p. avidum, p. granulosum, p. lymphophilum, the formerly so-called corynebacterium parvum, p. ...197944604
letter: corynebacterium parvum and anaesthetics. 197546085
editorial: immunological control of cancer. 197546965
letter: anaerobic corynebacteria and anaesthetics. 197547129
letter: corynebacterium parvum and anaesthetics. 197547551
letter: adjuvant contact suppression of experimental tumours. 197548032
letter: immunological control of cancer. 197548154
letter: toxicity of intravenous corynebacterium parvum. 197553574
letter: side-effects of intravenous corynebacterium parvum. 197553755
evidence for an allotypic marker on canine immunoglobulin. 197553927
[inhibition of antigenic competition by immunostimulants].the diminution of immune response against srbc induced in mice, by a prior injection of hrbc was counteracted by addition of certain immunostimulants to srbc. the intensity of inhibition of antigenic competition was related to the quantity of immunostimulant added to srbc. some immunostimulants (b. abortus, lipopolysaccharide) were more active than others (c. parvum, poly i : c). to inhibit antigenic competition immunostimulant had to be injected after or in mixture with srbc never before.197556240
analysis of anaerobic coryneform cell wall antigens by radioimmunoassay. 197556300
effect of immunomodulators on thymocyte suppressive activity in mice. 197828950
resistance to marek's disease. effect of corynebacterium parvum and marek's tumor cell vaccines on tumorigenesis in chickens.a study of nonspecific stimulation of the avian immune system with corynebacterium parvum and specific stimulation with marek's tumor cell vaccines revealed that nonspecifically stimulated outbred white leghorn-type cockerels had higher incidences of tumors than did controls. a study of tumor cell cytotoxicity of sera from marek's disease virus exposed birds indicated that humoral factors may play some role in tumor resistance.197824754
metronidazole and acne.the strong activity of metroindazole against obligate anaerobes suggested that the organism proprionobacterium acnes and the disease acne vulgaris might respond to treatment with this drug. thirty-three clinical isolated of p. acnes were tested and found to be highly resistant to metronidazole. prospects for its successful use in acne are remote.197660028
editorial: immunostimulation. 197660577
aerobic and anaerobic bacteriology of acute otitis media in children.tympanocentesis and aerobic and anaerobic cultivation of the middle-ear fluid obtained was performed through one or both tympanic membranes of 62 children with acute otitis media. aerobic bacteria alone, predominantely pneumococcus and hemophilus influenzae, were isolated from 57% of patients; anaerobic organisms alone, most commonly propionibacterium acnes and peptococcus, from 15%. thirteen percent yielded mixtures of aerobes and anaerobes, and several had multiple aerobic or anaerobic agents. ...197822590
biological purpose of acne.it is argued that the close endocrine control of human sebaceous glands and the likely effects of acne on selection indicate that both gland and disease have persisted because they are biologically useful. two possibilities are proposed: sebum may provide precursor substrates for metabolism and synthesis by the epidermis of compounds of both local and systemic importance; and the adjuvent properties of corynebacteria which colonise the active sebaceous glands of acne may facilitate certain gener ...197658315
[recent personal results in advanced bronchial cancer. palliative immuno-chemotherapy. 63 cases]. 197664125
study of elastolytic activity propionibacterium acnes and staphylococcus epidermis in acne vulgaris and in normal skin.histopathological sections of anetoderma-like scars from 10 patients with acne vulgaris showed a selective absence of elastic fibers around pilosebaceous follicles. this finding is similar to the histologic changes of "perifollicular elastolysis" reported by varadi. bacteria isolated by anaerobic and aerobic cultures of swabs of the skin surface and pus of these 10 patients, 12 others with active acne vulgaris and 8 normal subjects were studied with particular attention to staphylococcus epiderm ...197660023
studies on the regulation of lymphocyte reactivity by normal and activated macrophages. 197767900
immunochemotherapy in 34 cases of oat cell carcinoma of the lung with 19 complete responses.thirty-four previously untreated patients with oat cell carcinoma of the lung were treated with a myelotoxic combination of cyclophosphamide, adriamycin, methotrexate, ccnu, and corynebacterium parvum (regimen a) every 4 weeks, interspersed with a non-myelotoxic combination including bleomycin, vincristine, dehydroemetine, and corynebacterium parvum (regimen b) weekly the other 3 weeks or when hematologic toxicity prohibited administration of regimen a. hematologic toxicity was frequent but was ...197768827
[progress in medicine in individual presentations, xi. modern forms of therapy in acne].several pathogenetic factors contribute to the development of acne vulgaris. these include genetic predisposition, hormonal influences, increasing sebaceous secretion, bacterial colonization of the follicle and keratinization defects in the follicular epithelium. modern acne therapy can take specific forms on the basis of recent research on pathogenesis. sebostatic therapy can be performed by the topical application of benzoyl peroxide or the systemic administration of hormones (oestrogens, anti ...197773259
corynebacterium parvum toxicity. 197673819
immunotherapy of human cancer. 197765906
role of mononuclear infiltrating cells in pathogenesis of hepatitis.mice that have been injected with corynebacterium parvum have mononuclear-cell infiltrates in the liver lobules. in such mice a small dose of lipopolysaccharide endotoxin produced a lethal hepatitis, with high serum-transaminase concentrations, glycogen depletion, and hypoglycaemia. it is suggested that lipopolysaccharide triggers the release from the infiltrating mononuclear cells of factors toxic for hepatocytes. similarly certain parasitic and virus infections and graft-versus-host reactions ...197880531
possible mechanisms underlying the induction of cytotoxic macrophages by corynebacterium parvum: in vitro induction of cytotoxicity in normal macrophages by immune lymphocytes. 197881874
corynebacterium parvum and hyperthermia. 197882029
abscesses of the frontal lobe of the brain secondary to covert dental sepsis.the bacterial species found in pus aspirated from brain abscesses in two patients were typical of those found in dental sepsis. subsequently apical-root abscesses were demonstrated in the upper jaws of both patients. this evidence strongly suggests that these cerebral abscesses were secondary to dental sepsis which could have spread from the teeth to the frontal lobes by several possible antaomical pathways.197879867
the effect of corynebacterium parvum therapy on immunoglobulin class and igg subclass levels in cancer patients.detailed serological studies have been undertaken in a small group of cancer patients receiving nonspecific immunotherapy with corynebacterium parvum (c. parvum). these patients included 4 cases of recurrent malignant melanoma, 2 of stomach cancer and 2 of recurrent breast cancer. they all received an initial i.v. infusion of 20 mg of a formol killed suspension of c. parvum followed by 2 mg (i.m.) at weekly intervals for 10-11 weeks. this protocol consistently resulted in an increase in the circ ...197561040
[immunostimulation]. 197884450
evidence for the presence of an antitumor factor in serum of normal animals.we have previously reported finding a factor with antitumor activity (tnf, tumor necrosis factor) in extracts of serum from normal mice. the possibility that tnf exists in the blood of normal animals of other species was explored. horse, mouse, dog, human, sheep, calf, rat and shark serums were fractionated with (nh4)2so4 and filtered through s-200 sephacryl gel. proteins of molecular weight 90,000 to 180,000 were pooled, concentrated and dialyzed. tnf, determined by l-cell assay in vitro and me ...197986384
effect of propionibacterium acnes on the cellular immune responses to tumor-specific antigens on malignant rat liver cells.the effect of propionibacterium acnes on the cellular immune responses to tumor-specific membrane antigens was investigated by microcytotoxicity assays (ma) and 51cr release assays (cra) with use of mesenteric lymph node cells (lnc) of syngeneic bd iv and bd vi rats. bd rat liver cell lines transformed in vitro by chemical carcinogens were used as target cells with tumor-specific antigens. by ma, the lnc from rats that were inoculated with malignant liver cells under the adjuvant effect of heat- ...197986635
immunotherapy models in experimental animals. 197987018
precursors of the blood group mn antigens as human carcinoma-associated antigens. 197988088
chemotherapy of advanced head and neck cancer with methotrexate, bleomycin, and cis-diamminedichloroplatinum ii in an effective outpatient schedule.thirty-one patients with advanced cancer of the head and neck, twenty-six of whom had failed prior irradiation, were treated with an out-patient chemotherapy regimen combining methotrexate, bleomycin, and cis-diamminedichloroplatinum (ii). the overall response rate among evaluable patients was 61%, with 22.5% complete remission. if 6 additional patients not completing 3 weeks of treatment are included, the response rate was 51.4%. the median duration of partial remission was 3 months, but none o ...197988256
symptoms from corynebacterium parvum. 197661475
quantitation of skin bacteria: lethality of the wash solution used to remove bacteria.a widely used technique for the quantitative removal of bacteria from the skin uses a detergent, triton x-100 (p, t-octylphenoxynonaethoxyethanol), to remove and suspend the bacteria. we determined the half-life for the survival of five common skin bacteria suspended in the solution. the shortest-lived was streptococcus pyogenes with a half-life of 0.9 hours. all of the others (propionibacterium acnes, staphylococcus epidermidis, staphylococcus aureus, and klebsiella pneumoniae) had half-lives o ...197993373
[immunotherapy today. ii. immunostimulating therapy]. 197893770
antibiotic sensitivity of comedonal propionibacterium acnes.previous studies on antibiotic mic levels for p. acnes and p. granulosum have shown them generally sensitive to therapeutic levels in both blood and surface lipids. the clinical response of acne vulgaris to antibiotic therapy is slower than one would anticipate from in vitro studies. it is also delayed well beyond the time tetracycline is known to appear in surface lipids. the concentration of antibiotics in comedonal material could be important, but it is not known. to determine the sensitivity ...197994223
studies of the producer cell of interferon in human lymphocyte cultures.the producer cells of interferon were studied in human leucocyte cultures stimulated by a variety of stimulants, including phytohemagglutinin (pha), pokeweed mitogen (pwm), corynebacterium parvum (cp) and herpes simplex virus (hsv). when the cells were fractionated by the use of neuraminidase-treated sheep red blood cells (srbc), the t cell population responded with interferon production to pha and pwm but not to cp or hsv. however, the non-t population showed a vigorous response to the latter t ...197994306
malignant angioendothelioma--effect of immunotherapy with corynebacterium parvum. 197883086
protection against chemotherapy toxicity by iv hyperalimentation.a prospective randomized trial was conducted comparing the addition of iv hyperalimentation (ivh) to corynebacterium parvum, isophosphamide, and adriamycin (cia) chemoimmunotherapy in 26 patients with extensive squamous cell lung cancer. thirteen patients were entered in each treatment arm of the study and ivh was administered before and after the first course of cia for a total of 31 days. the major dose-limiting toxic effect of cia was leukopenia. less myelosuppression was observed for the pat ...197899235
prostaglandin synthesis in spleen cell cultures of mice injected with corynebacterium parvum. 1978102430
[action of corynebacterium parvum on the activity of glycosidases and proteases of peritoneal macrophages in the mice].glycosidase and peptidase of non-treated mouse peritoneal macrophages were characterized. the enzymatic activities of corynebacterium parvum stimulated mouse macrophages were compared to those of macrophages obtained from non-treated animals. all the enzymatic activities, but beta-c-galactosidase, were higher in stimulated mouse macrophages.1978102445
pharmacologic factors and manipulation of immunity systemic adjuvants in cancer therapy.because of the experimental and clinical studies which have been extensively conducted with bacillus calmette-guérin (bcg) as a systemic adjuvant in cancer immunotherapy, we have analyzed the main factors and conditions which determine its beneficial action and have underlined some of these (eg, the dose factor which controls the amplification of suppressor cells which is probably responsible for failures and even the possible tumor-enhancing effect of immunotherapy). knowing those factors and c ...1978103616
immunological cross-reactivity of oral non-streptococcal bacteria with mammalian tissue.the presence of cross-reacting antigens between oral non-steptococcal bacteria and human and monkey tissue was investigated by indirect immunofluorescence. rabbit antisera, prepared against 22 oral bacteria, were incubated with cryostatcut sections of heart, skeletal muscle, brain cord, liver, kidney, and skin. a cell wall antigen of lactobacillus casei was shared with neuroglial brain cells, and an antigenic component of propionibacterium acnes was shared with kidney glomeruli. tissue-reactive ...1979110702
adjuvant chemotherapy or chemoimmunotherapy in the management of primary malignant melanoma of level iii, iv, or v. 1978111323
[effect of corynebacterium parvum on the glycosidases in guinea pig alveolar macrophages. role of the way of introduction (author's transl)]. 1978111745
immunity to carcinogen-induced transplantable fibrosarcomas in b2/b2 chickens. iv. effect of whole-body gamma radiation on localization and growth of intravenously injected tumor cells. 1979112314
purification of antibodies to bacterial antigens by an immunoadsorbent and a method to quantify their reaction with insoluble bacterial targets.a combination of procedures was employed to develop a radioimmunoassay which quantified the binding of antibodies to antigens of either intact propionibacterium acnes or to antigens of insoluble extracts derived from the bacteria. reactive antibody populations were purified by use of bacterial immunoadsorbents which were prepared by coupling p. acnes to diethylaminoethyl cellulose. binding of antibodies was detected with [125i]staphylococcal protein a ([125i]spa) and optimal conditions for the a ...1979113462
particulate beta 1-3 glucan and casual prophylaxis of mouse malaria (plasmodium berghei). 1979121199
[effect of a polysan preparation for the treatment of acne on the growth of corynebacterium acnes and staphylococcus pyogenes aureus]. 1975125629
treatment of acne vulgaris with topically applied erythromycin and tretinoin.a twice daily application of 2% erythromycin base in hydroalcoholic solution accompanied by once daily use of 0.05% tretinoin (retinoic acid) solution was substantially more effective than tretinoin or erythromycin alone for treatment of inflammatory acne of moderate severity. therapeutic enhancement by this combination can be attributed to the different modes of action, erythromycin acting chiefly by suppressing propionibacterium acnes, while tretinoin is comedolytic. in addition, by altering t ...197883088
adjvant treatment of tongue and floor of the mouth cancers.since january 1974, 95 patients with anterior tongue and floor of the mouth cancers were included in a randomized trial. after stratification according to staging and initial treatment, one-third of the patients received chemotherapy for 2 years (methotrexate 400 mg followed by citrovorum factor 100 mg + bleomycin 60 mg/week, during the first 15 weeks), one-third of the patients received immunotherapy with weekly c. parvum injections during 2 years, while the remaining third did not receive any ...197888754
scientific approach to the treatment of acne vulgaris. 1975129306
lipolytic activity of microorganisms in acne vulgaris. 1975129776
ultrastructure of human sebaceous follicles and comedones following treatment with vitamin a acid.ultrastructural findings in normal human sebaceous follicles, of comedones from acne patients, and from comedones during topical treatment with vitamin a acid (vaa) are described. in normal human sebaceous follicles, the two segments of the infundibulum-the acroinfundibulum and the infrainfundibulum-show differing ultramorphological patterns of keratinization. the incomplete horny layer of the infrainfundibulum is physiological and seems to be necessary for its normal function. on the other hand ...1975130781
role of microorganisms in dandruff.the role of microorganisms in dandruff was studied, by suppressing individually and then collectively the three major components of the scalp microflora. the effect on dandruff was assessed subjectively by clinical grading and objectively by the corneocyte count. no effect on dandruff was demonstrated when scalp organisms were suppressed. in the second group of experiments, dandruff was suppressed by selenium sulfide shampooling and the effect of continued suppression of pityrosporum with topica ...1976130835
[sebaceous filaments (author's transl)].sebaceous filaments are cylindrical tubes of whitish-yellowish color, which can be expressed from areas of the face rich in sebaceous follicles by pinching the skin or by the cyanoacrylat-technique. sebaceous filaments are most commonly found in the centrofacial areas and the alae nasae in postpuberal individuals with large facial pores and seborrhea. sebaceous filaments are composed of a skeleton of 10-30 horny cell layers which enclose a mixture of bacteria, sebaceous lipid, corneocyte fragmen ...1976130839
acne vulgaris: current concepts in pathogenesis and treatment. 1976131110
the microbiology of dandruff. 1976131574
[the pathogenesis of acne vulgaris (author's transl)].stickl's method of oral treatment of acne vulgaris with antigens has been carried out on 26 test persons. during the treatment the number of comedones increased significantly and the number of papules decreased significantly. biochemically, a significant increase of the free fatty acids and a significant decrease of the triglycerides could be demonstrated in the skin surface lipids, the total amount remaining unchanged. the following important conclusions for the pathogenesis of acne may be draw ...1976131909
[studies on ozone therapy of acne vulgaris].ozone therapy using the vapozone 9, an instrument in normal commercial usage, has been carried out on the forehead of 16 male test persons on 7 consecutive days. before the treatment began and at the end of the treatment period the skin surface lipids on the unchanged skin (casual level) and two hours after defatting the skin (replacement sum) were taken by direct extraction and analysed by means of thin layer chromatography. the results of these investigations rule out a decrease in the free fa ...1976134522
topically applied antibiotics in acne vulgaris: clinical response and suppression of corynebacterium acnes in open comedones.topical antibiotics were used on patients with acne vulgaris. corynebacterium acnes organisms from open comedones were quantitated during treatment, and the progress of the disease was evaluated. clindamycin lotion completely suppressed the growth of c acnes organisms, whereas erythromycin and tetracycline did not depress the c acnes counts. taken as a group, these antibiotics gave a substantial improvement of the disease on the treated side as compared with paired untreated sides of the face a ...1976134675
quantification of bacteria in isolated pilosebaceous follicles in normal skin.a technique for quantitating bacteria in isolated pilosebaceous follicles is described. this involves microdissection of the follicles from biopsies of skin, using the method of chemical pretreatment of skin to facilitate the separation of the epidermis and epidermal appendages from the dermis. the aerobic cocci and anaerobic diphtheroids in pilosebaceous follicles in 66 biopsies of scalp and 48 biopsies of skin of the upper back were quantitated using this technique. on the back, aerobic staphy ...1975127814
ad hoc committee report: systemic antibiotics for treatment of acne vulgaris: efficacy and safety. 1975128326
propionibacterium acnes: pathogen in central nervous system shunt infection. report of three cases including immune complex glomerulonephritis.propionibacterium acnes is a pleomorphic gram-positive anaerobic rod usually isolated as a contaminant from skin. we report three cases of p. acnes infection of central nervous system shunts for hydrocephalus. the organism was seen repeatedly on gram stain in a specimen of shunt fluid in all three cases; initially, it was regarded as a contaminant. in addition, two of the patients had precipitins to extracts of their organism. serum from normal control subjects had no such precipitins. one of th ...1976137672
a reevaluation of fatty acids as inflammatory agents in acne.the currently widely held theory that intrafollicular free fatty acids (fa) are the primary agents instigating inflammatory changes in acne is based on circumstantial evidence. there is no direct evidence that fa in physiologic concentrations are inflammatory. in the present study the quantities of fa present in isolated pilosebaceous ducts and in isolated comedones were analyzed. using these values, the effect of fa on intracutaneous injection into human skin was investigated. the range of fa i ...1977137937
[acne vulgaris: review of the pathogenecity and the therapeutic problem from bacteriological view point (author's transl)]. 1976138000
a microbial etiology of acne?the view is advanced that sebum as originally produced must contain materials, other than lipids, which may serve as a selective substrate for growth of bacteria and yeasts. growth of large numbers of p. acnes and p. granulosum in some follicles is considered to place those follicles at risk of undergoing pathological changes. deleterious products of bacterial growth could be not only lipase and free fatty acids, but also other enzymes as well as bacterial antigens and unspecified toxins or irri ...1976138542
acne from an immunological perspective.patients with acne vulgaris, particularly those with severe inflammatory forms of the disease, are known to have high titers of serum antibodies, and intensified immediate hypersensitivity reactions to p. acnes antigens. the significance of this fact has not been clarified, but it is possible that antigen-antibody reactions involving p. acnes in the perifollicular dermis could intensify the inflammatory response in certain forms of acne. further studies utilizing newer, more sophisticated techni ...1976138543
antibiotic resistant acne.our approach to a patient who fails to respond to antibiotics is as follows: first, take a careful history. look for use of cosmetics and topical corticosteroids, anticonvulsive agents and systemic corticosteroids. inquire about marked increases in emotional or psychological stresses accompanied by noticeable seborrhea. probe the patient about habits of leaning on or squeezing acne areas, and most importantly, inquire how often and in what manner the patient washes. in the physical examination, ...1976138553
predominant cultivable microbiota in periodontosis. 1977138729
[gram-positive bacteria as adjuvants (author's transl)].gram-positive bacteria or their constituents influence the immune response in various ways. for instance: listeria monocytogenes cellwall fraction acts as b-cell mitogen, in this way enhancing a humoral immune response. corynebacterium parvum acts as a macrophage stimulant evoking maximum macrophage activation. bcg, among other things, leads to an enhancement of a t-cell response to unrelated antigens. the hypothetical therapeutic consequences are discussed.197896006
an acne-free naevus.investigation of rare disorders may sometimes help in the understanding of common problems. we describe a patient with an unusual and previously unreported acne-free naevus occurring in an area severely affected by acne. investigation revealed smaller sebaceous glands, a reduced sebum excretion rate, decreased number of corynebacterium acnes in the pilosebaceous ducts and a reduced conversion of testosterone to 5 alphadihydrotestosterone in the areas which were free of acne compared with acne-be ...1977139913
the inability of a bacterial lipase inhibitor to control acne vulgaris. 1977142119
[therapy of acne vulgaris using panoxyl]. 1977143138
an in vivo evaluation of the inflammatory effect of purified comedonal components in human skin. 1977143497
lymphocyte transformation in subjects with nodulo cystic acne.patients with severe nodulo-cystic acne are known to have elevated serum antibody levels and increased immediate hypersensitivity reactions to propionibacterium acnes. this organism is the predominant bacterium in normal pilosebaceous follicles of human skin, and can be consistently isolated from pustular lesions in acne. previously it had been observed that delayed cutaneous hypersensitivity reactions to p. acnes were negative in patients with acne. the present study investigated the proliferat ...1977143951
acne vulgaris: recent advances in pathogenesis and treatment.hormonal factors, particularly androgens, appear to be important in the pathogenesis of acne vulgaris. the sebaceous glands in acne are more sensitive to normal blood levels of androgens, and are stimulated to produce more sebum. corynebacterium acnes in the sebaceous follicles act on triglycerides in the sebum to form free fatty acids which might alter the process of keratinization in the follicular canal. a microcomedo is formed which can progress to the clinical lesions of acne. sebum and its ...1977144774
[strains of propionibacterium acnes isolated from acne vulgaris (author's transl)]. 1977146146
local microwave hyperthermia (43 degrees c) and stimulation of the macrophage and t-lymphocyte systems in treatment of guerin epithelioma in rats. 1978146340
[ultrastructure and microflora in follicles and comedones].the resident flora of skin surface, sebaceous follicles, and acne comedones: pityrosporum, micrococci, and corynebacterium (propionibacterium) acnes is described. the nomenclature, topography, incidence, pathogenic role, and especially the ultrastructural morphology of these organisms are presented.1976136430
acne fulminans: investigation of acute febrile ulcerative acne.eight cases of acne fulminans (acute febrile ulcerative acne) are compared with 13 previously reported cases. this rare disorder of male teenage patients is characterized by the sudden appearance of highly inflammatory, tender, ulcerative and crusted lesions on the back, chest, and face: it is one of the most scarring acute dermatologic disorders of young patients. at the onset of the disease, all patients showed febrile temperatures and marked leukocytosis; other systemic symptoms occurred with ...1977139850
lipases: their questionable role in acne vulgaris. 1976136423
skin surface glycerol levels in acne vulgaris.free glycerol would be expected from biochemical considerations to be an end product of lipolysis of sebum triglycerides. glycerol was measured in skin surface washings of acne vulgaris patients, in acne vulgaris patients treated for at least 3 mo with oral tetracycline and in control subjects. surface glycerol in untreated acne subjects was significantly less than that expected theoretically, whereas the amounts of such glycerol in treated acne patients and in control subjects closely approache ...1978148480
[porphyrinsynthesis of propionibacterium acnes in acne and seborrhea (author's transl)].the porphyrin productions of p a.-strains, isolated on the one hand from inlfammatory acne lesions, on the other hand from sebaceous follicle filaments from 10 persons each were compared quantitatively and qualitatively, after the appropriate material had been pooled, with respect to the acne strains one could observe a somewhat increased porphyrin production as well as the discharging of a precentually greater portion of porphyrins to the surrounding material. when separated by tlc the acne mat ...1978148872
complement activation by corynebacterium acnes. 1978148901
[effect of corynebacterium parvum on the immune response in guinea pigs. i. mode of enhancement of the anamnestic response and development of delayted hypersensitivity after treatment with corynebacterium parvum].the effect of corynebacterium parvum (c. parvuum) on the immune response of the guinea pig to ovalbumin varies with the protocol of immunization. the marked effect of c. parvum on the anamnestic response in the rabbit has been confirmed in the guinea pig when immunization is carried out intradermally with a mixture of c. parvum and ovalbumin. when c. parvum is given intravenously or subcutaneously or intradermally but separately from the antigen, this effect is not observed. whatever the route o ...1977148948
[effect of corynebacterium parvum on the immune response in guinea pigs. ii. passive transfer of enhanced anamnestic response and delayed hypersensitivity observed after treatment with corynebacterium parvum].after intradermal immunization with a mixture of corynebacterium parvum (c. parvum) and ovalbumin guinea pigs show a markedly increased anamnestic response to an intradermal booster of ovalbumin as compared to controls treated with ovalbumin only. at the same time a reaction of delayed type hypersensitivity is observed in the treated animals, but not in controls. the enhanced anamnestic response as well as the posivitive skin reaction were transferred to strain 2 histocompatible guinea pigs by p ...1977148949
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