| intergeneric and intrageneric inhibition between strains of propionibacterium acnes and micrococcaceae, particularly staphylococcus epidermidis, isolated from normal skin and acne lesions. | two hundred and forty-one strains or resident skin bacteria comprising 93 isolates of propionob acterium acnes and 148 of micrococcaceae derived from 36 acne patients and 8 control subjects were screened for their ability to inhibit 32 indicator strains, including 20 strains of p. acnes and 12 strains of staphylococcus epidermidis derived from patients with all grades of acne and from normal skin. fifty-three strains (22%) showed some activity against at least one indicator strain. both broad- a ... | 1979 | 34728 |
| production of hyaluronidase by propionibacteria from different origins. | 114 strains of anaerobic and microaerophilic coryneform bacteria from different origins were investigated for production of free extracellular hyaluronidase (hyaluronate glycanohydrolase, ec 3.2.1.36). a quantitative technique was applied measuring the release of n-acetyl-glucosamine groups from purified human potassium hyaluronate. the strains belonged to the following species: propionibacterium acnes, p. avidum, p. granulosum, p. lymphophilum, the formerly so-called corynebacterium parvum, p. ... | 1979 | 44604 |
| amino acid sequence of the biotinyl subunit from transcarboxylase. | the complete amino acid sequence of the biotinyl subunit from the enzyme transcarboxylase of propionibacterium shermanii has been determined from the structures of overlapping tryptic and cyanogen bromide peptides together with sequenator analysis on the whole subunit. the subunit contains 123 amino acid residues. eleven of nineteen residues in the region of biotin attachment, when compared to pyruvate carboxylase from avian liver (rylatt, d. b., keech, d. b., and wallace, j. c. (1977) arch. bio ... | 1979 | 40985 |
| the microbiology of serous and mucoid otitis media. | one hundred forty-four serous and mucoid effusions were cultured for aerobic bacteria, mycoplasma pneumoniae, and virus. thirty percent of all effusions yielded an unequivocally positive culture for aerobic bacteria. although serous effusions were culture positive as often as mucoid effusions, haemophilus influenzae was isolated predominantly from serous effusions and staphylococcus epidermidis predominantly from mucoid samples. only one of 73 effusions yielded a viral isolate (herpesvirus homin ... | 1979 | 36591 |
| [the bacterial flora of preputial space]. | the bacterial flora of the preputial space of 210 healthy males (43 children aged between 2 and 11 years, 137 males between 12 and 60 years and 30 men over 60 years) was determined by smears and cultueres from glans penis, sulcus coronarius and the adjacent prepuce. the results were grouped according to various criteria, e.g. glans covered or uncovered and age of males. differences in the distribution of germs could be found in relationship to age. in the case of an uncovered glans penis the pre ... | 1979 | 35486 |
| complement activation by propionibacterium acnes and bacteroides melaninogenicus. | | 1978 | 33641 |
| the role of bacteria in acne vulgaris: a new approach. | | 1978 | 32979 |
| effect of immunomodulators on thymocyte suppressive activity in mice. | | 1978 | 28950 |
| bacteriocin-like activities of human dental plaque flora against oral anaerobic microorganisms. | | 1977 | 26477 |
| resistance to marek's disease. effect of corynebacterium parvum and marek's tumor cell vaccines on tumorigenesis in chickens. | a study of nonspecific stimulation of the avian immune system with corynebacterium parvum and specific stimulation with marek's tumor cell vaccines revealed that nonspecifically stimulated outbred white leghorn-type cockerels had higher incidences of tumors than did controls. a study of tumor cell cytotoxicity of sera from marek's disease virus exposed birds indicated that humoral factors may play some role in tumor resistance. | 1978 | 24754 |
| investigation of the mechanism of the methylmalonyl-coa mutase reaction with the substrate analogue: ethylmalonyl-coa. | 1. ethylmalonyl-coa was found to be a substrate for methylmalonyl-coa mutase from propionibacterium shermanii, the product being mainly (2r)-methylsuccinyl-coa along with some (2s)-diastereoisomer. 2. the relevant 1h-nuclear magnetic resonance signals of methylsuccinic acid and of its dimethyl ester were assigned to the diastereotopic methylene hydrogens using sterospecifically dideuterated specimens of known configuration. 3. 2(-2)h1ethylmalonyl-coa was converted by methylmalonyl-coa mutase in ... | 1978 | 24538 |
| aerobic and anaerobic bacteriology of acute otitis media in children. | tympanocentesis and aerobic and anaerobic cultivation of the middle-ear fluid obtained was performed through one or both tympanic membranes of 62 children with acute otitis media. aerobic bacteria alone, predominantely pneumococcus and hemophilus influenzae, were isolated from 57% of patients; anaerobic organisms alone, most commonly propionibacterium acnes and peptococcus, from 15%. thirteen percent yielded mixtures of aerobes and anaerobes, and several had multiple aerobic or anaerobic agents. ... | 1978 | 22590 |
| purification of methylmalonyl-coa mutase from propionibacterium shermanii using affinity chromatography. | a novel procedure for the purification of methylmalonyl-ca mutase from propionibacterium shermanii has been described which employs affinity chromatography on a column of immobilized vitamin b-12 linked covalently to sepharose. the method has the advantage of being simple and rapid, thus enabling the purification of the enzyme to near homogeneity with good yields. | 1977 | 19074 |
| mechanism of inhibition of immunization with irradiated tumour cells by a large dose of corynebacterium parvum. | | 1977 | 18742 |
| the bacteriology of skin cysts. | thirty-nine clinically uninflamed cysts of the three most common varieties, epidermoid cysts, trichilemmal cysts and steatocystoma multiplex were removed under sterile conditions and the contents cultured under aerobic and anaerobic conditions. seventy-three percent of epidermoid cysts grew significant numbers of organisms whereas none of the trichilemmal cysts did so. the organisms found were the common skin commensals, staphylococcus epidermidis biotype i, anaerobic gram positive cocci of the ... | 1977 | 17428 |
| desugarization of egg white by microorganisms. | glucose was eliminated from egg whites, using microorganisms, to prevent melanoidin formation which may damage the product. desugarization was achieved by means of acetobacter xylinum, streptococcus lactis, propionibacterium shermanii, pr. petersonii and propionicacid cocci. optimal conditions of desugarization were found, depending on the physiological characteristics of the above microorganisms. propionibacterium shermanii may be well used to ferment a liquid egg white. these bacteria have no ... | 1976 | 17113 |
| a new large form of transcarboxylase with six outer subunits and twelve biotinyl carboxyl carrier subunits. | a new form of transcarboxylase has been isolated which has a molecular weight of 1,200,000, an s20,w of 26 s, and contains 12 biotinyl groups. transcarboxylase as isolated previously has a molecular weight of 790,000, an s20,w of 18 s, and contains six biotinyl groups. the larger species of enzyme consists of a central hexameric subunit with six dimeric outer subunits attached to it by biotinyl carboxyl carrier proteins, three each at the opposite faces of the central subunits. this larger speci ... | 1977 | 14153 |
| antimicrobial effects of some bis-biguanides on certain bacteria which occur in connection with acne vulgaris. | | 1976 | 6710 |
| the biosynthesis of vitamin b12. | the use of 13c-fourier transform nuclear magnetic resonance (f.t.-n.m.r.) has led to the observation that while 8 molecules of 2-13cala are incorporated into vitamin b12 in p. shermanii, 5-13cala labels only seven of the carbon atoms of cyanocobalamin, i.e. one of the amino methyl groups of ala is "lost" in the process. it has also been confirmed that seven of the methyl groups of b12 are derived from 13ch3-enriched methionine and further that the chirality of the gemdimethyl grouping at c12 lab ... | 1976 | 4839 |
| letter: corynebacterium parvum and anaesthetics. | | 1975 | 47551 |
| aldolases of the lactic acid bacteria. demonstration of immunological relationships among eight genera of gram positive bacteria using an anti-pediococcal aldolase serum. | reciprocal qualitative and quantitative immunological experiments employing an anti-pediococcus cerevisiae aldolase serum confirmed many of the interspecific relationships demonstrated previously among lactic acid bacteria with antisera prepared against the streptococcus faecalis fructose diphosphate aldolase. the extent of immunological relatedness observed between the lactobacillus and pediococcus aldolases was markedly gses indicating that the pediococci share closer phylogenetic ties with th ... | 1976 | 65160 |
| letter: anaerobic corynebacteria and anaesthetics. | | 1975 | 47129 |
| editorial: immunological control of cancer. | | 1975 | 46965 |
| letter: corynebacterium parvum and anaesthetics. | | 1975 | 46085 |
| the role of bacteroides melaninogenicus and other anaerobes in periodontal infections. | recent taxonomic and anatomical studies of dental plaque associated with periodontal health and disease have demonstrated that differences in the microbial populations in plaque may be responsible for the initiation and progression of disease. the consistent isolation of large numbers of anaerobic and capnophilic bacteria from the depths of periodontal lesions has suggested an important role for these organisms. bacteria that have been isolated include capnocytophaga (bacteroides ochraceus), oth ... | 1979 | 44923 |
| [physiologo-biochemical features of the growth and development of propionibacterium shermanii in egg albumin]. | propionibacterium shermanii was shown to be able of growing in such an unusual substrate as egg albumen. incubation of the bacterium in egg albumen results in complete utilization of free carbohydrates in this substrate and accumulation in it of such bacterial metabolites as vitamins b2 and b12, free amino acids, bacterial protein, acetic and propionic acids which favour conservation of egg albumen. the bacterium does not possess proteolytic activity and does not utilize albumen; in the conditio ... | 1979 | 43462 |
| purification and partial characterization of hyaluronate lyase (ec 4.2.2.1) from propionibacterium acnes. | hyaluronidase from propionibacterium acnes has been purified 13,000-fold from the culture supernatant to homogeneity (as determined by polyacrylamide disc gel electrophoresis). the molecular weight of the purified enzyme was 85,110 as determined by gel filtration. the purified enzyme had a ph optimum at 6.4, was stable between ph 5 and 5.8 and was completely inactivated after 15 min at 50 degrees c. preliminary studies suggested that the enzyme is active against chondroitin 4- and 6-sulphates, b ... | 1979 | 43356 |
| [effect of aeration on growth retardation of propionibacterium shermanii at different ph values]. | | 1979 | 41167 |
| possible mechanisms underlying the induction of cytotoxic macrophages by corynebacterium parvum: in vitro induction of cytotoxicity in normal macrophages by immune lymphocytes. | | 1978 | 81874 |
| corynebacterium parvum and hyperthermia. | | 1978 | 82029 |
| isolation of genital mycoplasmas from blood obtained shortly after vaginal delivery. | blood obtained from three hundred and twenty-seven women within a few minutes of vaginal delivery was cultured for genital mycoplasmas (mycoplasma hominis and t mycoplasmas). twenty-six (8%) of the women had genital mycoplasmas isolated from their blood. ten women had blood-cultures which contained m. hominis. fifteen women had blood-cultures which contained t mycoplasmas. both m. hominis and t mycoplasmas were isolated from the blood of one woman. only one of two hundred and seventy-three blood ... | 1975 | 47945 |
| letter: adjuvant contact suppression of experimental tumours. | | 1975 | 48032 |
| letter: immunological control of cancer. | | 1975 | 48154 |
| production of antibodies that bind biotin and inhibit biotin containing enzymes. | methods were developed for the coupling of biotin to bovine serum albumin and bovine gamma-globulin using a water-soluble carbodimide. the use of [14-c]biotin as a tracer allowed quantitation of the incorporation of biotin into the conjugates: 2.55 mol of biotin was incorporated per mol of gamma-globulin and 7-9 mol of biotin was incorporated per mol of serum albumin in different preparations. these conjugates were highly immunogenic in the rabbit and anti-bodies reactive with the biotinyl group ... | 1975 | 49192 |
| letter: toxicity of intravenous corynebacterium parvum. | | 1975 | 53574 |
| letter: side-effects of intravenous corynebacterium parvum. | | 1975 | 53755 |
| evidence for an allotypic marker on canine immunoglobulin. | | 1975 | 53927 |
| [inhibition of antigenic competition by immunostimulants]. | the diminution of immune response against srbc induced in mice, by a prior injection of hrbc was counteracted by addition of certain immunostimulants to srbc. the intensity of inhibition of antigenic competition was related to the quantity of immunostimulant added to srbc. some immunostimulants (b. abortus, lipopolysaccharide) were more active than others (c. parvum, poly i : c). to inhibit antigenic competition immunostimulant had to be injected after or in mixture with srbc never before. | 1975 | 56240 |
| adjvant treatment of tongue and floor of the mouth cancers. | since january 1974, 95 patients with anterior tongue and floor of the mouth cancers were included in a randomized trial. after stratification according to staging and initial treatment, one-third of the patients received chemotherapy for 2 years (methotrexate 400 mg followed by citrovorum factor 100 mg + bleomycin 60 mg/week, during the first 15 weeks), one-third of the patients received immunotherapy with weekly c. parvum injections during 2 years, while the remaining third did not receive any ... | 1978 | 88754 |
| analysis of anaerobic coryneform cell wall antigens by radioimmunoassay. | | 1975 | 56300 |
| biological purpose of acne. | it is argued that the close endocrine control of human sebaceous glands and the likely effects of acne on selection indicate that both gland and disease have persisted because they are biologically useful. two possibilities are proposed: sebum may provide precursor substrates for metabolism and synthesis by the epidermis of compounds of both local and systemic importance; and the adjuvent properties of corynebacteria which colonise the active sebaceous glands of acne may facilitate certain gener ... | 1976 | 58315 |
| study of elastolytic activity propionibacterium acnes and staphylococcus epidermis in acne vulgaris and in normal skin. | histopathological sections of anetoderma-like scars from 10 patients with acne vulgaris showed a selective absence of elastic fibers around pilosebaceous follicles. this finding is similar to the histologic changes of "perifollicular elastolysis" reported by varadi. bacteria isolated by anaerobic and aerobic cultures of swabs of the skin surface and pus of these 10 patients, 12 others with active acne vulgaris and 8 normal subjects were studied with particular attention to staphylococcus epiderm ... | 1976 | 60023 |
| metronidazole and acne. | the strong activity of metroindazole against obligate anaerobes suggested that the organism proprionobacterium acnes and the disease acne vulgaris might respond to treatment with this drug. thirty-three clinical isolated of p. acnes were tested and found to be highly resistant to metronidazole. prospects for its successful use in acne are remote. | 1976 | 60028 |
| studies of the producer cell of interferon in human lymphocyte cultures. | the producer cells of interferon were studied in human leucocyte cultures stimulated by a variety of stimulants, including phytohemagglutinin (pha), pokeweed mitogen (pwm), corynebacterium parvum (cp) and herpes simplex virus (hsv). when the cells were fractionated by the use of neuraminidase-treated sheep red blood cells (srbc), the t cell population responded with interferon production to pha and pwm but not to cp or hsv. however, the non-t population showed a vigorous response to the latter t ... | 1979 | 94306 |
| identification of bacteroides fragilis by indirect immunofluorescence. | rabbit antiserum against live or heat-killed bacteroides fragilis nctc 9343 bacteria was titrated against hot phenol water-extracted polysaccharide antigens from five different species of the 'b. fragilis group' of bacteria using an enzyme immunoassay and shown to be specific for the b. fragilis nctc 9343 polysaccharide. when the antiserum was used in indirect immunofluorescence, 97.1% of 244 b. fragilis strains were correctly identified. only 8 of the other 312 bacteroides strains were stained ... | 1979 | 94651 |
| [gram-positive bacteria as adjuvants (author's transl)]. | gram-positive bacteria or their constituents influence the immune response in various ways. for instance: listeria monocytogenes cellwall fraction acts as b-cell mitogen, in this way enhancing a humoral immune response. corynebacterium parvum acts as a macrophage stimulant evoking maximum macrophage activation. bcg, among other things, leads to an enhancement of a t-cell response to unrelated antigens. the hypothetical therapeutic consequences are discussed. | 1978 | 96006 |
| protection against chemotherapy toxicity by iv hyperalimentation. | a prospective randomized trial was conducted comparing the addition of iv hyperalimentation (ivh) to corynebacterium parvum, isophosphamide, and adriamycin (cia) chemoimmunotherapy in 26 patients with extensive squamous cell lung cancer. thirteen patients were entered in each treatment arm of the study and ivh was administered before and after the first course of cia for a total of 31 days. the major dose-limiting toxic effect of cia was leukopenia. less myelosuppression was observed for the pat ... | 1978 | 99235 |
| the effect of corynebacterium parvum therapy on immunoglobulin class and igg subclass levels in cancer patients. | detailed serological studies have been undertaken in a small group of cancer patients receiving nonspecific immunotherapy with corynebacterium parvum (c. parvum). these patients included 4 cases of recurrent malignant melanoma, 2 of stomach cancer and 2 of recurrent breast cancer. they all received an initial i.v. infusion of 20 mg of a formol killed suspension of c. parvum followed by 2 mg (i.m.) at weekly intervals for 10-11 weeks. this protocol consistently resulted in an increase in the circ ... | 1975 | 61040 |
| immunotherapy of human cancer. | | 1977 | 65906 |
| studies on the regulation of lymphocyte reactivity by normal and activated macrophages. | | 1977 | 67900 |
| immunological cross-reactivity of oral non-streptococcal bacteria with mammalian tissue. | the presence of cross-reacting antigens between oral non-steptococcal bacteria and human and monkey tissue was investigated by indirect immunofluorescence. rabbit antisera, prepared against 22 oral bacteria, were incubated with cryostatcut sections of heart, skeletal muscle, brain cord, liver, kidney, and skin. a cell wall antigen of lactobacillus casei was shared with neuroglial brain cells, and an antigenic component of propionibacterium acnes was shared with kidney glomeruli. tissue-reactive ... | 1979 | 110702 |
| adjuvant chemotherapy or chemoimmunotherapy in the management of primary malignant melanoma of level iii, iv, or v. | | 1978 | 111323 |
| immunochemotherapy in 34 cases of oat cell carcinoma of the lung with 19 complete responses. | thirty-four previously untreated patients with oat cell carcinoma of the lung were treated with a myelotoxic combination of cyclophosphamide, adriamycin, methotrexate, ccnu, and corynebacterium parvum (regimen a) every 4 weeks, interspersed with a non-myelotoxic combination including bleomycin, vincristine, dehydroemetine, and corynebacterium parvum (regimen b) weekly the other 3 weeks or when hematologic toxicity prohibited administration of regimen a. hematologic toxicity was frequent but was ... | 1977 | 68827 |
| immunity to carcinogen-induced transplantable fibrosarcomas in b2/b2 chickens. iv. effect of whole-body gamma radiation on localization and growth of intravenously injected tumor cells. | | 1979 | 112314 |
| purification of antibodies to bacterial antigens by an immunoadsorbent and a method to quantify their reaction with insoluble bacterial targets. | a combination of procedures was employed to develop a radioimmunoassay which quantified the binding of antibodies to antigens of either intact propionibacterium acnes or to antigens of insoluble extracts derived from the bacteria. reactive antibody populations were purified by use of bacterial immunoadsorbents which were prepared by coupling p. acnes to diethylaminoethyl cellulose. binding of antibodies was detected with [125i]staphylococcal protein a ([125i]spa) and optimal conditions for the a ... | 1979 | 113462 |
| [progress in medicine in individual presentations, xi. modern forms of therapy in acne]. | several pathogenetic factors contribute to the development of acne vulgaris. these include genetic predisposition, hormonal influences, increasing sebaceous secretion, bacterial colonization of the follicle and keratinization defects in the follicular epithelium. modern acne therapy can take specific forms on the basis of recent research on pathogenesis. sebostatic therapy can be performed by the topical application of benzoyl peroxide or the systemic administration of hormones (oestrogens, anti ... | 1977 | 73259 |
| corynebacterium parvum toxicity. | | 1976 | 73819 |
| abscesses of the frontal lobe of the brain secondary to covert dental sepsis. | the bacterial species found in pus aspirated from brain abscesses in two patients were typical of those found in dental sepsis. subsequently apical-root abscesses were demonstrated in the upper jaws of both patients. this evidence strongly suggests that these cerebral abscesses were secondary to dental sepsis which could have spread from the teeth to the frontal lobes by several possible antaomical pathways. | 1978 | 79867 |
| role of mononuclear infiltrating cells in pathogenesis of hepatitis. | mice that have been injected with corynebacterium parvum have mononuclear-cell infiltrates in the liver lobules. in such mice a small dose of lipopolysaccharide endotoxin produced a lethal hepatitis, with high serum-transaminase concentrations, glycogen depletion, and hypoglycaemia. it is suggested that lipopolysaccharide triggers the release from the infiltrating mononuclear cells of factors toxic for hepatocytes. similarly certain parasitic and virus infections and graft-versus-host reactions ... | 1978 | 80531 |
| malignant angioendothelioma--effect of immunotherapy with corynebacterium parvum. | | 1978 | 83086 |
| treatment of acne vulgaris with topically applied erythromycin and tretinoin. | a twice daily application of 2% erythromycin base in hydroalcoholic solution accompanied by once daily use of 0.05% tretinoin (retinoic acid) solution was substantially more effective than tretinoin or erythromycin alone for treatment of inflammatory acne of moderate severity. therapeutic enhancement by this combination can be attributed to the different modes of action, erythromycin acting chiefly by suppressing propionibacterium acnes, while tretinoin is comedolytic. in addition, by altering t ... | 1978 | 83088 |
| ultrastructure of human sebaceous follicles and comedones following treatment with vitamin a acid. | ultrastructural findings in normal human sebaceous follicles, of comedones from acne patients, and from comedones during topical treatment with vitamin a acid (vaa) are described. in normal human sebaceous follicles, the two segments of the infundibulum-the acroinfundibulum and the infrainfundibulum-show differing ultramorphological patterns of keratinization. the incomplete horny layer of the infrainfundibulum is physiological and seems to be necessary for its normal function. on the other hand ... | 1975 | 130781 |
| [immunostimulation]. | | 1978 | 84450 |
| evidence for the presence of an antitumor factor in serum of normal animals. | we have previously reported finding a factor with antitumor activity (tnf, tumor necrosis factor) in extracts of serum from normal mice. the possibility that tnf exists in the blood of normal animals of other species was explored. horse, mouse, dog, human, sheep, calf, rat and shark serums were fractionated with (nh4)2so4 and filtered through s-200 sephacryl gel. proteins of molecular weight 90,000 to 180,000 were pooled, concentrated and dialyzed. tnf, determined by l-cell assay in vitro and me ... | 1979 | 86384 |
| effect of propionibacterium acnes on the cellular immune responses to tumor-specific antigens on malignant rat liver cells. | the effect of propionibacterium acnes on the cellular immune responses to tumor-specific membrane antigens was investigated by microcytotoxicity assays (ma) and 51cr release assays (cra) with use of mesenteric lymph node cells (lnc) of syngeneic bd iv and bd vi rats. bd rat liver cell lines transformed in vitro by chemical carcinogens were used as target cells with tumor-specific antigens. by ma, the lnc from rats that were inoculated with malignant liver cells under the adjuvant effect of heat- ... | 1979 | 86635 |
| immunotherapy models in experimental animals. | | 1979 | 87018 |
| precursors of the blood group mn antigens as human carcinoma-associated antigens. | | 1979 | 88088 |
| chemotherapy of advanced head and neck cancer with methotrexate, bleomycin, and cis-diamminedichloroplatinum ii in an effective outpatient schedule. | thirty-one patients with advanced cancer of the head and neck, twenty-six of whom had failed prior irradiation, were treated with an out-patient chemotherapy regimen combining methotrexate, bleomycin, and cis-diamminedichloroplatinum (ii). the overall response rate among evaluable patients was 61%, with 22.5% complete remission. if 6 additional patients not completing 3 weeks of treatment are included, the response rate was 51.4%. the median duration of partial remission was 3 months, but none o ... | 1979 | 88256 |
| quantitation of skin bacteria: lethality of the wash solution used to remove bacteria. | a widely used technique for the quantitative removal of bacteria from the skin uses a detergent, triton x-100 (p, t-octylphenoxynonaethoxyethanol), to remove and suspend the bacteria. we determined the half-life for the survival of five common skin bacteria suspended in the solution. the shortest-lived was streptococcus pyogenes with a half-life of 0.9 hours. all of the others (propionibacterium acnes, staphylococcus epidermidis, staphylococcus aureus, and klebsiella pneumoniae) had half-lives o ... | 1979 | 93373 |
| pathogenesis of acne vulgaris. | | 1976 | 134973 |
| [changes in the physiologic properties of a chemostat culture of propionibacterium shermanii during growth limitation by a deficiency of sodium lactate]. | a chemostat curve has been constructed for changes in the propionibacterium shermanii population density with an increase in the flow rate of the medium from 0.04 to 0.55 h-1 upon limitation of the growth with sodium lactate deficiency. the curve differs from the classic chemostat curve described with the monod equation, thus indicating changes in metabolism at different growth rates. fermentation of lactate to acetic and propionic acids by the culture is most complete at low flow rates of the m ... | 1979 | 93687 |
| [immunotherapy today. ii. immunostimulating therapy]. | | 1978 | 93770 |
| antibiotic sensitivity of comedonal propionibacterium acnes. | previous studies on antibiotic mic levels for p. acnes and p. granulosum have shown them generally sensitive to therapeutic levels in both blood and surface lipids. the clinical response of acne vulgaris to antibiotic therapy is slower than one would anticipate from in vitro studies. it is also delayed well beyond the time tetracycline is known to appear in surface lipids. the concentration of antibiotics in comedonal material could be important, but it is not known. to determine the sensitivity ... | 1979 | 94223 |
| editorial: immunostimulation. | | 1976 | 60577 |
| symptoms from corynebacterium parvum. | | 1976 | 61475 |
| utilization of lactose and production of corrinoids in selected strains of propionic acid bacteria in cheese-whey and casein media. | comparative studies were carried out with 23 strains (14 species) of propionibacteria in two media-cheese-whey and casein. the degree of lactose fementation and the efficiency of the corrinoids synthesis were studied. lactose fermentation showed great differences even within one species (e.g. 13.3% and 66.1% for various strains of p. shermanii). the differences were particularly sharp in casein medium (0% or 100%). the highest capacity for utilizing cheese-whey lactose (70--80%) was found in two ... | 1976 | 62496 |
| [recent personal results in advanced bronchial cancer. palliative immuno-chemotherapy. 63 cases]. | | 1976 | 64125 |
| pharmacologic factors and manipulation of immunity systemic adjuvants in cancer therapy. | because of the experimental and clinical studies which have been extensively conducted with bacillus calmette-guérin (bcg) as a systemic adjuvant in cancer immunotherapy, we have analyzed the main factors and conditions which determine its beneficial action and have underlined some of these (eg, the dose factor which controls the amplification of suppressor cells which is probably responsible for failures and even the possible tumor-enhancing effect of immunotherapy). knowing those factors and c ... | 1978 | 103616 |
| [effect of corynebacterium parvum on the glycosidases in guinea pig alveolar macrophages. role of the way of introduction (author's transl)]. | | 1978 | 111745 |
| particulate beta 1-3 glucan and casual prophylaxis of mouse malaria (plasmodium berghei). | | 1979 | 121199 |
| acne fulminans: investigation of acute febrile ulcerative acne. | eight cases of acne fulminans (acute febrile ulcerative acne) are compared with 13 previously reported cases. this rare disorder of male teenage patients is characterized by the sudden appearance of highly inflammatory, tender, ulcerative and crusted lesions on the back, chest, and face: it is one of the most scarring acute dermatologic disorders of young patients. at the onset of the disease, all patients showed febrile temperatures and marked leukocytosis; other systemic symptoms occurred with ... | 1977 | 139850 |
| propionibacterium levels in patients with and without acne vulgaris. | propionibacterium species were quantified on the foreheads and cheeks of persons with and without acne in three age groups: 11 to 15, 16 to 20, and 21 to 25. propionibacteria were virtually absent in the pubertal non-acne group compared to a geometric mean density of 114,800 per sq cm in the acne group. a similar sharp difference existed between the acne subjects and normals in the age range of 16 to 20 years: 85,800 organisms per sq cm compared to 588 per sq cm. patients with acne and normal su ... | 1975 | 126263 |
| quantification of bacteria in isolated pilosebaceous follicles in normal skin. | a technique for quantitating bacteria in isolated pilosebaceous follicles is described. this involves microdissection of the follicles from biopsies of skin, using the method of chemical pretreatment of skin to facilitate the separation of the epidermis and epidermal appendages from the dermis. the aerobic cocci and anaerobic diphtheroids in pilosebaceous follicles in 66 biopsies of scalp and 48 biopsies of skin of the upper back were quantitated using this technique. on the back, aerobic staphy ... | 1975 | 127814 |
| ad hoc committee report: systemic antibiotics for treatment of acne vulgaris: efficacy and safety. | | 1975 | 128326 |
| scientific approach to the treatment of acne vulgaris. | | 1975 | 129306 |
| lipolytic activity of microorganisms in acne vulgaris. | | 1975 | 129776 |
| role of microorganisms in dandruff. | the role of microorganisms in dandruff was studied, by suppressing individually and then collectively the three major components of the scalp microflora. the effect on dandruff was assessed subjectively by clinical grading and objectively by the corneocyte count. no effect on dandruff was demonstrated when scalp organisms were suppressed. in the second group of experiments, dandruff was suppressed by selenium sulfide shampooling and the effect of continued suppression of pityrosporum with topica ... | 1976 | 130835 |
| [blastogenic response in vitro of lymphocyte acne vulgaris]. | 32 patients with different degrees of acne and 10 healthy controls were studied. on every one of them the test for lymphocytic transformation was performed looking for the range of blastogenic response, using pha and ca. the positive findings with ca related to those obtained in normal subject would support the hypotesis that the cellular immunity as a response to ca antigens would be different in each patient according to the host local conditions. | 1977 | 147371 |
| [sebaceous filaments (author's transl)]. | sebaceous filaments are cylindrical tubes of whitish-yellowish color, which can be expressed from areas of the face rich in sebaceous follicles by pinching the skin or by the cyanoacrylat-technique. sebaceous filaments are most commonly found in the centrofacial areas and the alae nasae in postpuberal individuals with large facial pores and seborrhea. sebaceous filaments are composed of a skeleton of 10-30 horny cell layers which enclose a mixture of bacteria, sebaceous lipid, corneocyte fragmen ... | 1976 | 130839 |
| acne vulgaris: current concepts in pathogenesis and treatment. | | 1976 | 131110 |
| the microbiology of dandruff. | | 1976 | 131574 |
| [the pathogenesis of acne vulgaris (author's transl)]. | stickl's method of oral treatment of acne vulgaris with antigens has been carried out on 26 test persons. during the treatment the number of comedones increased significantly and the number of papules decreased significantly. biochemically, a significant increase of the free fatty acids and a significant decrease of the triglycerides could be demonstrated in the skin surface lipids, the total amount remaining unchanged. the following important conclusions for the pathogenesis of acne may be draw ... | 1976 | 131909 |
| [comparative evaluation of the action of a propionic-acidophilic bouillon culture in dyspepsia]. | | 1976 | 133531 |
| topically applied antibiotics in acne vulgaris: clinical response and suppression of corynebacterium acnes in open comedones. | topical antibiotics were used on patients with acne vulgaris. corynebacterium acnes organisms from open comedones were quantitated during treatment, and the progress of the disease was evaluated. clindamycin lotion completely suppressed the growth of c acnes organisms, whereas erythromycin and tetracycline did not depress the c acnes counts. taken as a group, these antibiotics gave a substantial improvement of the disease on the treated side as compared with paired untreated sides of the face a ... | 1976 | 134675 |
| lipases: their questionable role in acne vulgaris. | | 1976 | 136423 |
| [ultrastructure and microflora in follicles and comedones]. | the resident flora of skin surface, sebaceous follicles, and acne comedones: pityrosporum, micrococci, and corynebacterium (propionibacterium) acnes is described. the nomenclature, topography, incidence, pathogenic role, and especially the ultrastructural morphology of these organisms are presented. | 1976 | 136430 |
| propionibacterium acnes: pathogen in central nervous system shunt infection. report of three cases including immune complex glomerulonephritis. | propionibacterium acnes is a pleomorphic gram-positive anaerobic rod usually isolated as a contaminant from skin. we report three cases of p. acnes infection of central nervous system shunts for hydrocephalus. the organism was seen repeatedly on gram stain in a specimen of shunt fluid in all three cases; initially, it was regarded as a contaminant. in addition, two of the patients had precipitins to extracts of their organism. serum from normal control subjects had no such precipitins. one of th ... | 1976 | 137672 |
| a reevaluation of fatty acids as inflammatory agents in acne. | the currently widely held theory that intrafollicular free fatty acids (fa) are the primary agents instigating inflammatory changes in acne is based on circumstantial evidence. there is no direct evidence that fa in physiologic concentrations are inflammatory. in the present study the quantities of fa present in isolated pilosebaceous ducts and in isolated comedones were analyzed. using these values, the effect of fa on intracutaneous injection into human skin was investigated. the range of fa i ... | 1977 | 137937 |
| cellular immunity to p. acnes in the normal population and patients with acne vulgaris. | patients with varying degrees of acne, acne-free adult controls and samples of cord blood were investigated for cell mediated immunity to p. acnes using a leukocyte migration inhibition test. despite the fact that the mean migration index tended to decrease with acne severity, only the patients with severe acne showed cell-mediated immunity. it is suggested that when cellular immunity arises it is a late event which may contribute to inflammation but is probably not a factor in its initiation. | 1978 | 150284 |
| prostaglandin synthesis in spleen cell cultures of mice injected with corynebacterium parvum. | | 1978 | 102430 |