proceedings: bacterial degradation of calcium benzamidosalicylate. 19752722
significance of microorganisms found in throat swabs (author's transl). 19763776
adherence of bacterial to vaginal epithelial cells.vaginal epithelial cells from healthy women were washed and incubated in tissue culture medium with freshly isolated bacteria of the indigenous vaginal flora and with bacteria of species that have been discussed in conjunction with genital infections. after incubation and washing, the number of bacteria that adhered per cell was determined. the influence on the attachment rate of such factors as variations in the washing procedure, bacterial density, and incubation time was assessed. lactobacill ...19765372
ph and eh in single and mixed culture bacterial plaque in an artificial mouth. 19765393
bacterial diseases of farmed fishes. 19765781
the detection of toxin production by corynebacterium diphtheriae in diagnostic vitro tests for assessing the toxigenicity of strains of c. diphtheriae using the original agar plate precipitin method of elek are unreliable. at high concentrations of antitoxin (500-1000 u/ml) multiple non-specific precipitin lines occur making interpretation difficult. increased specificity was obtained by diluting the antitoxin but this in turn caused a delay in the appearance of toxin-antitoxin lines. also, the failure of lines to appear on media enriched with unsuitable serum may lead ...19769614
role of epitope density in the induction of immunity and tolerance with thymus-independent antigens. i. studies with 2,4-dinitrophenyl conjugates in vitro.the effect of different degrees of conjugation of levan, dextran, pneumococcal polysaccharide siii and the copolymer of d-glutamic acid and d-lysine with the 2,4-dinitrophenyl determinant (dnp) on the immunogenic and tolerogenic capacity of its haptenic conjugates was investigated in vitro. a strikingly uniform effect of hapten conjugation was observed despite the marked difference in the mol. wt. and structure (branched or linear) of the carrier molecules. regarding the anti-dnp response, low d ...197510172
antimicrobial activity of tibezonium (tbz).the activity in vitro of tibezonium (rec 15-0691), a new 1,5-benzodiazepine derivative, has been investigated. the drug was found active especially against streptococcus, diplococcus and corynebacterium strains which are agents of oropharyngeal diseases. the activity of tibezonium was ph dependent against staphylococcus aureus sg 511 and streptococcus pyogenes 821 (at ph 8.0-8.5 it was more active) and the presence of horse serum provoked a small decrease of the antimicrobial properties. no inte ...197712928
o-alkylhomoserine synthesis catalyzed by o-acetylhomoserine sulfhydrylase in enzyme that can synthesize o-alkylhomoserine from alcohols and o-acetylhomoserine was purified from corynebacterium acetophilum. the enzyme was found to be identical to o-acetylhomoserine sulfhydrylase; a preparation that appeared homogeneous on polyacrylamide gel electrophoresis showed both o-alkylhomoserine-synthesizing and o-acetylhomoserine sulfhydrylase activities. its molecular weight was determined to be about 220,000, and it consisted of two subunits. its ph and temperature optima for ...197715989
determination of the effective concentration of jodonal a for the disinfection of the skin and teats after milking.the bactericidal effectivity of jodonal a in 1:10, 1:5, and 1:3 solutions was tested on human skin and on the teats of cow mammary glands. the 1:3 dilution ratio proved best for three-minute exposure. jodonal a used in this concentration in 522 cows for the post-milking disinfection of teats for 10 months exerted no harmful effect on the skin of the mammary glands.197616377
devitalizing effect of jodonal a in vitro on bacteria subject to a short-term a three-minute exposure in vitro jodonal a devitalized a culture of serological group b streptococci in a 2% concentration, staphylococcus aureus in a 16% concentration, pneumococcus in a 4.5% concentration, corynebacterium pyogenes in a 2.5% concentration, pseudomonas aeruginosa in a 3% concentration, and klebsiella pneumoniae in a 2% concentration. hence jodonal a concentrations higher than 16% should be tested for udder teat disinfection after the removal of teat cups.197616378
the bacteriology of skin cysts.thirty-nine clinically uninflamed cysts of the three most common varieties, epidermoid cysts, trichilemmal cysts and steatocystoma multiplex were removed under sterile conditions and the contents cultured under aerobic and anaerobic conditions. seventy-three percent of epidermoid cysts grew significant numbers of organisms whereas none of the trichilemmal cysts did so. the organisms found were the common skin commensals, staphylococcus epidermidis biotype i, anaerobic gram positive cocci of the ...197717428
mechanism of inhibition of immunization with irradiated tumour cells by a large dose of corynebacterium parvum. 197718742
properties and biodegradation of a bioemulsifier from corynebacterium extracellular polymer was produced by continuous fermentation of corynebacterium hydrocarboclastus on kerosene in a 24 liter reactor. this polymer was composed of protein, lipid, and carbohydrates. the polymer possessed surface active properties, and had two critical micelle concentrations. its effectiveness was quite comparable to the effectiveness of synthetic surface active agents such as tween 80 and span 20; however, its efficiency was much lower. the polymer also had emulsifying propert ...197719111
diphtheria toxin. 197720040
influence of acetohydroxamic acid on experimental corynebacterium renale pyelonephritis.the role of corynebacterium renale urease in the establishment of pyelonephritis was studied by the oral administration of acetohydroxamic acid (aha), a urease inhibitor, to experimentally infected rats. the bacteria were introduced by surgical insertion of a zinc disc containing 1 x 10(6) colony-forming units of c-renale into the urinary bladder whereas sterile discs were implanted in the bladders of the control animals. daily administration of aha via the drinking water did not halt the develo ...197721738
diagnosis and treatment of vaginitis. 197722249
resistance to marek's disease. effect of corynebacterium parvum and marek's tumor cell vaccines on tumorigenesis in chickens.a study of nonspecific stimulation of the avian immune system with corynebacterium parvum and specific stimulation with marek's tumor cell vaccines revealed that nonspecifically stimulated outbred white leghorn-type cockerels had higher incidences of tumors than did controls. a study of tumor cell cytotoxicity of sera from marek's disease virus exposed birds indicated that humoral factors may play some role in tumor resistance.197824754
inhibition of chemical carcinogenesis by corynebacterium parvum. 197827800
effect of prolonged occlusion on the microbial flora, ph, carbon dioxide and transepidermal water loss on human skin.the effects of prolonged occlusion on the normal microbial skin flora, ph, transepidermal water loss (tewl) and carbon dioxide emission rate (cder) were studied. the total average counts before occlusion were 1.8 x 10(2)/cm(2) and increased to 4.5 x 10(6) on day 5. the highest counts were noted on day 4(9.8 x 10(7)/cm(2)). the composition changed: controls comprised of 63% coagulase negative staphylococci, 6% micrococci, 17% diphtheroids and 6% bacilli. after 5 days of occlusion, the percent com ...197831403
influence of soil ph and calcium nutrition on resistance of alfalfa to bacterial and verticillium wilt.alfalfa plants of a resistant, a susceptible and a highly susceptible strains were grown in unlimed soil at ph 5.8 and in limed one at ph 6.9 and inoculated by the pathogens of vascular wilt, corynebacterium insidiosum and verticillium albo-atrum. two types of liming were performed: 1) before inoculation and 2) after inoculation. liming of the soil led to an increase in number of resistant plants. in susceptible plants the external symptoms of disease on the plant tops were delayed or alleviated ...197832703
[the bacterial flora of preputial space].the bacterial flora of the preputial space of 210 healthy males (43 children aged between 2 and 11 years, 137 males between 12 and 60 years and 30 men over 60 years) was determined by smears and cultueres from glans penis, sulcus coronarius and the adjacent prepuce. the results were grouped according to various criteria, e.g. glans covered or uncovered and age of males. differences in the distribution of germs could be found in relationship to age. in the case of an uncovered glans penis the pre ...197935486
the microbiology of serous and mucoid otitis hundred forty-four serous and mucoid effusions were cultured for aerobic bacteria, mycoplasma pneumoniae, and virus. thirty percent of all effusions yielded an unequivocally positive culture for aerobic bacteria. although serous effusions were culture positive as often as mucoid effusions, haemophilus influenzae was isolated predominantly from serous effusions and staphylococcus epidermidis predominantly from mucoid samples. only one of 73 effusions yielded a viral isolate (herpesvirus homin ...197936591
conditions for in vitro haemolytic activity by corynebacterium ovis exotoxin.a substance, concluded to be corynebacterium ovis exotoxin on the basis of properties shared, was found to have haemolytic activity below ph 6 and red cell adhesion activity at neutral or slightly alkaline ph. an acidified, solid blood agar medium was used to demonstrate the extent of haemolysis that could be obtained at optimal ph and its inhibition by immune serum. culture in a liquid medium giving rise to a suitably acidic ph allowed titration for haemolytic activity by the exotoxin and use o ...197942127
biosynthesis of ethylene from methionine. isolation of the putative intermediate 4-methylthio-2-oxobutanoate from culture fluids of bacteria and fungi.methods are described for identifying the 2,4-dinitrophenylhydrazones of 4-methylthio-2-oxobutanoate by means of t.l.c., n.m.r. and mass spectroscopy. by using these methods 4-methylthio-2-oxobutanoate, a putative intermediate in the biosynthesis of ethylene from methionine, has been identified in culture fluids of aeromonas hydrophila b12e and a coryneform bacterium d7f grown in the presence of methionine. relative to 4-methylthio-2-oxobutanoate, the yield of 3-(methylthio)propanal (methional) ...197942392
the normal microbial flora of the baboon vagina.the microbial flora of the upper vagina and cervix was examined in 38 adult baboons at various stages of the menstrual cycle. the mean number of different species isolated from each baboon was 9.5, with species of bacteroides, corynebacterium and group d streptococci predominating. lactobacilli and mycoplasmas were found in 47.4 and 44.7% of the animals, respectively. no ureaplasms were isolated. cyclical variations in the microbial flora were minimal.197943896
non-specific induction of increased resistance in mice to trypanosoma congolense and trypanosoma brucei by immunostimulants.administration of the immunostimulants corynebacterium parvum, bacillus calmette-guérin (bcg) or bordetella pertussis prior to, or at the same time as, challenge with trypanosoma congolense significantly increased survival times in mice, both of trypano-susceptible (a/j) and trypano-resistant (c57bl) strains. the increased survival time was associated with significant alterations in parasitaemia, which included lengthening of the pre-patent period, a delay in the time taken to reach the first pe ...197944360
production of hyaluronidase by propionibacteria from different origins.114 strains of anaerobic and microaerophilic coryneform bacteria from different origins were investigated for production of free extracellular hyaluronidase (hyaluronate glycanohydrolase, ec a quantitative technique was applied measuring the release of n-acetyl-glucosamine groups from purified human potassium hyaluronate. the strains belonged to the following species: propionibacterium acnes, p. avidum, p. granulosum, p. lymphophilum, the formerly so-called corynebacterium parvum, p. ...197944604
a simple method of detecting staphylococcal hemolysins.a modification of the "one-plate method" for detection of staphylococcal hemolysins has been described. bacterial strains of staphylococcus aureus, streptococcus agalactiae and cornebacterium pseudotuberculosis were replaced by their prepurified hemolytically active exosubstances: beta-toxin, camp-factor, and, the exosubstance of corynebacterium pseudotuberculosis called corex. by means of the modification described, exact detection of hemolysins in possible with staphylococcal strains producing ...197944782
haemagglutinating activity of corynebacterium xerosis isolated from human periodontal lesions. 197944852
letter: corynebacterium parvum and anaesthetics. 197546085
letter: recognition of diphtheria. 197546974
letter: avirulent corynebacteria. 197547127
letter: anaerobic corynebacteria and anaesthetics. 197547129
letter: corynebacterium parvum and anaesthetics. 197547551
letter: recognition of diphtheria. 197547573
letter: immunological control of cancer. 197548154
non-toxigenic corynebacterium diphtheriae in a boarding school.a non-toxigenic strain of corynebacterium diphtheriae var. gravis was isolated from 31 boys during an outbreak of sore throats at a boarding school of 15 staff and 134 pupils. despite the non-toxigenicity of the strain involved, conventional isolation procedures were observed and all boys at the school were treated with antibiotics. restrictions on the school were only relaxed when no further carriers were detected. the rationale of such management of an episode involving a non-toxigenic strain ...197548687
letter: recognition of diphtheria. 197548850
haemophilus somnus complex: antigenicity and specificity of fractions of haemophilus somnus.five haemophilus somnus type 8025 preparations (whole cell, sonicate, crude polysaccharide, purified polysaccharide, and protein) were produced for studies of their antigenicity in rabbits. bacterial agglutination and passive hemagglutination tests were used to assess the level of antibody produced in rabbits inoculated with the different antigenic preparations. cross-reactions were seen between the antiserums against the h sumnus 8025 antigens and a variety of related and unrelated bovine patho ...197550755
[bacteriological studies of butirosin sulfate, a new aminoglycoside antibiotic (author's transl)]. 197551941
letter: toxicity of intravenous corynebacterium parvum. 197553574
letter: side-effects of intravenous corynebacterium parvum. 197553755
quantitative assay of diphtherial toxin and of immunologically cross-reacting proteins by reversed passive hemagglutination.a reversed passive hemagglutination (rpha) assay for diptherial toxin has been developed. antitoxic antibodies were isolated from commercially available equine diptherial antitoxin by immunoabsorption using highly purified diphtherial toxin covalently linked to sepharose 4b. formalinized, tanned sheep erythrocytes sensitized with the purified antitoxic antibodies are specifically agglutinated by diphtherial toxin but are not agglutinated by extracellular antigens of corynebacterium diptheriae th ...197554339
immunochemical study of the peptidoglycan of gram-negative bacteria.the specificity of antibodies directed against the peptidoglycan of gram-negative bacteria was studied. the peptidoglycans of proteus vulgaris, escherichia coli, moraxella glucidolytica, neisseria perflava, give identical precipitin reactions. by means of inhibition studies with various peptidoglycan subunits and synthetic peptides, it was shown that the antibodies are essentially directed against the peptide moiety of the peptidoglycan: l-ala-d-glu (l)-mesoa2pm-(l)-d-ala, that the peptide react ...197660233
the effect of corynebacterium parvum therapy on immunoglobulin class and igg subclass levels in cancer patients.detailed serological studies have been undertaken in a small group of cancer patients receiving nonspecific immunotherapy with corynebacterium parvum (c. parvum). these patients included 4 cases of recurrent malignant melanoma, 2 of stomach cancer and 2 of recurrent breast cancer. they all received an initial i.v. infusion of 20 mg of a formol killed suspension of c. parvum followed by 2 mg (i.m.) at weekly intervals for 10-11 weeks. this protocol consistently resulted in an increase in the circ ...197561040
[use of fermented and purified diphtheria antitoxin for determination of pathogenicity of corynebacterium diphtheriae]. 197661328
symptoms from corynebacterium parvum. 197661475
a gram stain for smears of blood cultures, body fluids and tissues.a new gram stain method for blood cultures was adapted from a method for tissue sections. this was accomplished by comparing various modifications of the latter method on positive smears prepared from a 24-hour negative blood culture seeded with staphylococcus aureus and escherichia coli. a blind study was then conducted using the new method and hucker's method on 24-hour and 72-hour blood cultures as well as a limited number of other body fluids and tissues. of the 35 positive blood cultures de ...197662513
tinopal an in fluorescent microscopic detection of bacteria within plant tissues. 197663163
a continuous-wear hydrophilic lens. prophylactic topical antibiotics.seventeen patients, who were fitted with a continuous-wear hydrophilic lens for 12 weeks, received topical neomycin sulfate-polymyxin b sulfate-gramicidin (neosporin) eyedrops in one eye only at a frequency of 3.7 times per day. the continuous wear of a hydrophilic lens in and of itself did not after normal bacterial flora, and the use of the antibiotic drops did not alter normal conjunctival flora. in addition, the eyedrops were not more effective when used in conjunction with the hydrophilic l ...197663278
[minor diphtheria epidemic in a cologne children's home (author's transl)].between may and july 1972, 12 children aged from 7 to 14 were admitted to the cologne university children's hospital suspected of having diphtheria. in 10 cases the tonsils or pharyngeal cavity were affected. one case of wound diphtheria and one of nasal diphtheria were observed. the clinical suspicion was confirmed in 8 of 12 cases by detection of the pathogen coryne-bacterium diphtheroides mitis. 11 patients were discharged from the hospital after being treated for between 2 to 6 weeks, but 5 ...197664924
response of cultured mammalian cells to the exotoxins of pseudomonas aeruginosa and corynebacterium diphtheriae: differential cytotoxicity.the sensitivities of 21 mammalian cell lines to the exotoxins of pseudomonas aeruginosa and corynebacterium diphtheriae were measured. each line exhibited 1-4 log differences in sensitivities to the two toxins. no species-specific sensitivities were noted for pseudomonas exotoxin while diphtheria exotoxin was most potent in cells of monkey origin, followed by human and hamster cells. rat- and mouse-derived cell lines were very insensitive to diphtheria exotoxin. the rates of cellular intoxicatio ...197765205
[erythrasma of the nails].we have studied 17 cases of pseudomycotic onychoses. this condition is frequently seen in the toe nails with the clinical aspect of hyperkeratosis of the nail bed and onycholysis. the giemsa stained preparations have been performed with the clinical material previously heated in a 40% ohk solution and washed out with distilled water by centrifugation. the microorganism has similar or identical characteristics to those of the agent of erythrasma of the folds. its morphology and physiological char ...197665505
[antimicrobial immunity as a factor in stimulating antitumor mechanisms]. 197666658
[changes in the serum proteins in suppurative surgical infection in cattle].studied were the serum proteins of 3 cattle with a spontaneous suppurative surgery infection and 10 cattle with an experimental infection of the same character. it was found that in such cases there is a rise in the total protein, the alpha and gamma globulins, and a drop in the albumin and the beta-globulins. the experimental suppurative infection caused by corynebacterium pyogenes produces changes of a higher degree in the protein spectrum than the experimental infection caused by str. pyogene ...197667698
immunochemotherapy in 34 cases of oat cell carcinoma of the lung with 19 complete responses.thirty-four previously untreated patients with oat cell carcinoma of the lung were treated with a myelotoxic combination of cyclophosphamide, adriamycin, methotrexate, ccnu, and corynebacterium parvum (regimen a) every 4 weeks, interspersed with a non-myelotoxic combination including bleomycin, vincristine, dehydroemetine, and corynebacterium parvum (regimen b) weekly the other 3 weeks or when hematologic toxicity prohibited administration of regimen a. hematologic toxicity was frequent but was ...197768827
corynebacterium bovis as a cause of human disease.corynebacterium bovis is a gram-positive rod which can cause bovine mastitis and rancidity in cream. on only one occasion has this organism been reported to cause human disease. six further cases are described in which infections were caused by c. bovis. in two patients the nervous system was involved; two patients had bacterial endocarditis; one had chronic otitis media; and one had a persistent leg ulcer. five patients recovered completely from the infection; the other died from endocarditis.197771496
studies on the specificity of killing of intracellular pathogens by macrophages. 197771951
[adsorption of the antigen-reactive cells on the membrane reinforced immunosorbent]. 197772857
corynebacterium parvum toxicity. 197673819
cornyebacterium vaginale urinary-tract infection in a man. 197876762
corynebacterium vaginale bacteraemia in a man. 197876912
an unusual case of cutaneous diphtheria. 197879663
corynebacterium spp in human disease. 197879741
abscesses of the frontal lobe of the brain secondary to covert dental sepsis.the bacterial species found in pus aspirated from brain abscesses in two patients were typical of those found in dental sepsis. subsequently apical-root abscesses were demonstrated in the upper jaws of both patients. this evidence strongly suggests that these cerebral abscesses were secondary to dental sepsis which could have spread from the teeth to the frontal lobes by several possible antaomical pathways.197879867
immunochemical relatedness among ribosomes of mycobacteria, nocardia and corynebacteria [proceedings]. 197880189
role of mononuclear infiltrating cells in pathogenesis of hepatitis.mice that have been injected with corynebacterium parvum have mononuclear-cell infiltrates in the liver lobules. in such mice a small dose of lipopolysaccharide endotoxin produced a lethal hepatitis, with high serum-transaminase concentrations, glycogen depletion, and hypoglycaemia. it is suggested that lipopolysaccharide triggers the release from the infiltrating mononuclear cells of factors toxic for hepatocytes. similarly certain parasitic and virus infections and graft-versus-host reactions ...197880531
possible mechanisms underlying the induction of cytotoxic macrophages by corynebacterium parvum: in vitro induction of cytotoxicity in normal macrophages by immune lymphocytes. 197881874
[bacteriocinogenic activity of corynebacterium diphtheriae]. 197881920
corynebacterium parvum and hyperthermia. 197882029
malignant angioendothelioma--effect of immunotherapy with corynebacterium parvum. 197883086
polypeptide antibiotic 26a from bacillus subtilis. iv. evaluation of biological in vivo activity.the studies performed with the antibiotic 26a, which has a close resemblance to bacitracin family polypeptide antibiotics, revealed a prominent therapeutic and protective actions. the antibiotic is characterized by a moderately low toxicity, lack of cytotoxic and cytostatic effects on several tissue cultures, and therapeutic effectiveness in lethal streptococcal infections in mice, and corynebacterial infections in guinea pigs.197886285
the puzzle of "urethral syndrome": a possible answer?82 strains of slow-growing, co2-dependent, gram-positive organisms have been isolated from the urine of 9 male and 73 female patients. 100% of the men and 93% of the women had urinary symptoms at the time of isolation, and 66% of the specimens showed pyuria. these organisms might account for the urinary symptoms of some patients previously diagnosed as having "urethral syndrome". preliminary data show that, if appropriate antibacterial treatment is given, most of these patients become symptom-fr ...197986778
[immunotherapy of malignant growths (author's transl)].our knowledge of antigens which are associated with different types of malignant tumours is steadily increasing. these antigens exist in considerable numbers, but, so far with few exceptions, only their presence can be demonstrated by certain methods; to isolate and identify them has not yet been possible. these antigens are, therefore, suitable not so much for the primary diagnosis, but rather, like the carcinoembryonic antigen, the tissue-polypeptide antigen or the alpha-feto-protein, for asse ...197988728
macrophage immunity to influenza virus: in vitro and in vivo studies.using m-tur, a macrophage-adapted avian influenza a virus (hav1, nav3), antiviral resistance of peritoneal macrophages obtained from specifically or nonspecifically immunized mice towards in vitro infection was assessed. m-tur grew to high titers in macrophages from nonimmune mice thereby causing a marked cytopathic effect. in contrast, peritoneal macrophages from mice specifically immunized with tur virus were not affected by infection with m-tur in vitro. this antiviral immunity was specific: ...197989051
a comparison of the antibacterial properties of some udder creams and ointments.the antibacterial activity of three udder creams and two ointments was assayed using three different methods. seven different bacterial genera were used as test organisms providing a total of 17 strains. only a single strain of corynebacterium was inhibited by all the preparations. certain strains of staphylococci and streptococci were inhibited by four of the preparations. the gram-negative organisms showed greatest resistance to the antibacterial agents tested. the in vitro assays showed only ...197989750
rheumatoid arthritis: review of searches for an infectious cause. part ii. 197992461
studies of the producer cell of interferon in human lymphocyte cultures.the producer cells of interferon were studied in human leucocyte cultures stimulated by a variety of stimulants, including phytohemagglutinin (pha), pokeweed mitogen (pwm), corynebacterium parvum (cp) and herpes simplex virus (hsv). when the cells were fractionated by the use of neuraminidase-treated sheep red blood cells (srbc), the t cell population responded with interferon production to pha and pwm but not to cp or hsv. however, the non-t population showed a vigorous response to the latter t ...197994306
[the mechanism of adenine nucleotide biosynthesis from adenine in corynebacterium species].the mechanism of atp biosynthesis from adenine was studied on the cell-free extract of corynebacterium species that produces atp from exogenous adenine, using labeled substrates. as a source of the ribosyl component of the atp molecule, phosphoribosyl pyrophosphate (prpp) and ribose-5-phosphate (p5p) were tested. the experiments with prpp showed adenine phosphoribosyl transferase (ec activity in the extract responsible for the amp formation from prpp and adenine. the minimal reaction mi ...197995886
[gram-positive bacteria as adjuvants (author's transl)].gram-positive bacteria or their constituents influence the immune response in various ways. for instance: listeria monocytogenes cellwall fraction acts as b-cell mitogen, in this way enhancing a humoral immune response. corynebacterium parvum acts as a macrophage stimulant evoking maximum macrophage activation. bcg, among other things, leads to an enhancement of a t-cell response to unrelated antigens. the hypothetical therapeutic consequences are discussed.197896006
value of acid metabolic products in identification of certain corynebacteria.acid metabolic products of 23 strains of human and animal pathogenic corynebacteria, representing eight different species, were determined by gas chromatography. the results showed that the species examined were metabolically heterogeneous and could be presumptively identified based on the acid products produced. corynebacterium equi did not produce any acids; c. renale produced lactate; and c. pyogenes produced major amounts of lactate, variable amounts of acetate, and minor amounts of succinat ...197896126
rapid determination of corynebacterium diphtheriae toxigenicity by counterimmunoelectrophoresis.a method for detecting toxin production in corynebacterium diphtheriae cultures by counterimmunoelectrophoresis is described. precipitin lines were observed in toxigenic strains in 30 min.197896129
chemotherapy for malignant melanoma: a brief review and personal experience.chemotherapy for melanoma can be divided into four types: (i) intralesional chemotherapy; (ii) systemic chemotherapy to prevent the development of anticipated metastases; (iii) therapy for established disease; and (iv) combined with immunotherapy. apart from a few general rules, it is difficult to predict the response to treatment. the smaller the bulk of tumour, the more likely is regression under treatment. metastases in the skin, and to a lesser extent those in lymph nodes and lung, respond b ...197896784
isolation of the l-phase variant from toxigenic corynebacterium diphtheriae c7(beta).the l-phase variant was isolated from lysogenic strain c7(beta) of corynebacterium diphtheriae by the penicillin disk tecnnique on an agar medium containing 3.7% brain heart infusion, 3% nacl, 1.25% grycine, 1% noble agar, and 10% horse serum. the l-phase formed a "fried egg" colony; it was resistant to antibiotics that inhibit biosynthesis of bacterial cell walls but was susceptible to antibiotics that act on the protein-synthesizing system. after several transfers of the l-phase initially isol ...197897222
role of exotoxins in bacterial pathogenicity. 197897256
[prospects for the use of blood substitutes made in the ussr with the expired date of validity].as revealed, blood substitutes--aminopeptide, caseine hydrolysate, and hydrolysine with the expired date of validity could be used as the basis of nutrient media for the cultivation of bacteria. bacterial growth proved to be the optimum in addition to the blood substitutes of a 0.25--0.5% of yeast extract.197897885
[peptidoglycan type and cell wall polysaccharide composition of cellulomonas cartalyticum and some coryneform organisms (author's transl)].cellulomonas cartalyticum was found to contain a peptidoglycan type different from that of the other species of cellulomonas. the diamino acid is lysin instead of ornithine and the interpeptide bridge consists of d-asp-d-ser. the same peptidoglycan type occurs in corynebacterium manihot, brevibacterium liticum and arthrobacter luteus. these non cellulolytic organisms are most likely not closely related with cellulomonas cartalyticum, as indicated by the very different g +c content of their dna, ...197898123
ocular flora in the severely burned hundred six eyes of 53 patients with severe thermal burns were studied with serial conjunctival cultures during a four-month period. a dramatic shift of the normal conjunctival flora from the preponderance of staphylococcus epidermidis and corynebacterium to s aureus and gram-negative bacilli was observed. this commonly occurred on the fifth to sixth postburn day and represented colonization of the conjunctiva by bacteria recovered from other sites in the body. despite the high incidence of ...197898138
evidence that the regulation of diphtheria toxin production is directed at the level of has been known for several decades that iron inhibits the production of diphtheria toxin by corynebacterium diphtheriae by preventing expression at maximal levels. we examined the inhibition kinetics of toxin production after the addition of either iron or rifampin to iron-limited cultures of c7 (betatox+). iron-mediated inhibition of toxin production was found to be linear within the range of 16 nm to 16 micron. the inhibition kinetics following the addition of iron or rifampin was almost id ...197898519
microbiology of the vagina in children: normal and potentially pathogenic organisms.vaginal cultures from 100 healthy girls, 2 months to 15 years of age, were examined for the presence of normal and potentially pathogenic microorganisms. corynebacterium vaginale, yeast species, and genital mycoplasmas were isolated from vaginal cultures from 13.5 %, 28%, and 28% of the girls examined, respectively. colonization with these organisms was not associated with signs or symptoms of vaginitis. neisseria gonorrhoeae was isolated from a 4-year-old with purulent vaginitis. trichomonas va ...197898750
studies on the occurrence of peptococcus indolicus and corynebacterium pyogenes in abscesses in swine, and on the occurrence of pc. indolicus in apparently normal skin and mucous membranes of piglets.pc. indolicus was isolated from 42.7% and cb. pyogenes from 48.7% of 150 pus-samples from abscesses in pigs (slaughter-house material, table i). in 41 specimens the two organisms were found together. further, pc. indolicus was demonstrated in 22.4% of 290 swabs from apparently normal skin and mucous membranes of piglets (autopsy material, table ii). by gel diffusion analysis the strains of pc. indolicus were referred to the serotypes b, c, d, e, or f. the type distribution (table iii) possibly r ...197898755
[antitumor activity of the bacterial walls of br. abortus 99].a brief chronologic survey is made of investigations that reveal that the bacterial cell walls and their chemical components exhibit antitumoral activity. discussed is the problem which are the constituents of the bacterial wal and what is the mechanism through which such effects are produced. the conclusion is drawn that some peptides participating in the structure of the bacterial wall after their release in body stimulate the macrophages and thus confer antitumoral activity to them.197898899
vaccination and hodgkin's disease. 197899187
protection against chemotherapy toxicity by iv hyperalimentation.a prospective randomized trial was conducted comparing the addition of iv hyperalimentation (ivh) to corynebacterium parvum, isophosphamide, and adriamycin (cia) chemoimmunotherapy in 26 patients with extensive squamous cell lung cancer. thirteen patients were entered in each treatment arm of the study and ivh was administered before and after the first course of cia for a total of 31 days. the major dose-limiting toxic effect of cia was leukopenia. less myelosuppression was observed for the pat ...197899235
[biological assays of the quality of protein from h2-oxidizing bacteria in rats]. 197899907
[antagonistic and bacteriocinogenic activity of meningococci].antagonistic and bacteriocinogenic activity was studied in 169 strains of meningococci of various serological groups and with different localization in the human organism at the time of isolation. bacteriocinogenic activity was revealed in all the meningococcus strains (by delayed antagonism method), and, in addition, antagonistic activity was found in 100 strains. the inhibitory activity was the greatest in meningococci isolated from the cerebrospinal fluid. the data obtained suggest an importa ...197899921
[serologic relationship between toxigenic and nontoxigenic c. diphtheriae with reference to the cultural variant gravis]. 197899927
[epiedmiologic significance of the distribution of corynephages in different collectives].corynephage distribution was studied in the nasopharyngeal washings of 252 persons infected with c. diphtheriae of gravis type, toxigenic (21 patients and 147 carriers) and non-toxigenic ones (84 carriers), and in 468 uninfected persons in collective bodies under different epidemic conditions. corynephages were isolated from the nasopharyngeal washings only in persons infected with toxigenic c. diphtheriae--in 4 (of 21) patients, and in 21% (of 147) carriers. phages tox+ (4--6.2%) were revealed ...197899930
the effects of nisin on the microbial flora of the dental plaque of monkeys (macaca fascicularis). 1978100489
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