| urease assay and urease-producing species of anaerobes in the bovine rumen and human feces. | a growth medium and test were developed for rapid detection of urease in fermentative anaerobic bacteria. using nonselective rumen fluid roll-tube agar medium and the new test, it was confirmed that peptostreptococcus productus is often the most numerous urease-forming species in human feces. also, some fecal strains of ruminococcus albus, clostridium innocuum, and clostridium beijerinckii produced urease. single strains of fusobacterium prausnitzii, coprococcus catus, and streptococcus mitis th ... | 1977 | 879770 |
| reduction of nitroolefin using microorganisms. | microbial reduction of 1-phenyl-2-nitro-1-propene (3) was carried out using 57 strains of yeast, 40 strains of aerobic and facultatively anaerobic bacteria and 40 strains of strictly anaerobic bacteria. nine strains of yeast (candida tropicalis, etc.,) had the ability to reduce (3) to 1-phenyl-2-nitropropane (1) (94.1%-60.3% yield). the ability of the aerobic and anaerobic bacteria was weaker than yeast (35.6%-14.0% and less than 5%, respectively). when 11 strains of strictly anaerobic bacteria ... | 1990 | 2092944 |
| colobronchial fistula: a rare complication of crohn's colitis. | a 29-yr-old white woman presented with chronic pneumonia in the left lower lobe and with left pleural effusion. she was known to have inflammatory bowel disease, but she was asymptomatic under maintenance treatment with 5-asa. she received numerous antibiotic regimens according to susceptibility testing of microorganisms cultured from sputum and bronchial lavage and on an empiric basis was also given antituberculosis treatment, but there was no clinical improvement or change in the chest radiogr ... | 1990 | 2240849 |
| construction of the mycoplasma evolutionary tree from 5s rrna sequence data. | the 5s rrna sequences of eubacteria and mycoplasmas have been analyzed and a phylogenetic tree constructed. we determined the sequences of 5s rrna from clostridium innocuum, acholeplasma laidlawii, acholeplasma modicum, anaeroplasma bactoclasticum, anaeroplasma abactoclasticum, ureaplasma urealyticum, mycoplasma mycoides mycoides, mycoplasma pneumoniae, and mycoplasma gallisepticum. analysis of these and published sequences shows that mycoplasmas form a coherent phylogenetic group that, with c. ... | 1985 | 2579388 |
| partial purification and characterization of an nad-dependent 3 beta-hydroxysteroid dehydrogenase from clostridium innocuum. | in nine strains of clostridium innocuum, 3 beta-hydroxysteroid-dehydrogenating activities were detected. 3 beta, 7 alpha, 12 alpha-trihydroxy- and 3 beta-hydroxy-12-keto-5 beta-cholanoic acids were identified as reduction products of the respective 3-keto bile acids by gas-liquid chromatography and gas-liquid chromatography-mass spectrometry. one strain was shown to contain a nad-dependent 3 beta-hydroxysteroid dehydrogenase. enzyme production was constitutive in the absence of added bile acids. ... | 1989 | 2764572 |
| purification and properties of 3 alpha-hydroxyglycyrrhetinate dehydrogenase of clostridium innocuum from human intestine. | 3 alpha-hydroxyglycyrrhetinate dehydrogenase of clostridium innocuum, isolated from human intestinal bacteria, was capable of converting 3-ketoglycyrrhetic acid to 3 alpha-hydroxyglycyrrhetic acid. the enzyme was purified to homogeneity by means of butyl-toyopearl 650m, sephadex g-150, matrex red a, toyopearl hw-55s, and isoelectric focusing column chromatographies. the purified enzyme showed a specific activity of 156 mumol/min.mg toward 3 alpha-hydroxyglycyrrhetic acid, and showed a single ban ... | 1988 | 3164718 |
| urease activity in gastrointestinal tract of rabbit and electrophoretic behaviour of urease. | urease activity in the stomach (fundus and antrum), caecal content and soft faeces of rabbit was studied. significant differences between fundus and antral content (p less than 0.01) and between caecum and soft faeces (p less than 0.05) were observed. the urease zymograms from caecal content and soft faeces of rabbit presented two different bands. the fundus content and the caecal ureolytic clostridium innocuum bacterium exhibited only one band. band b of caecal content was not evident at ph 4, ... | 1986 | 3426157 |
| [a case of pseudomembranous colitis with the detection of klebsiella oxytoca and clostridium innocuum in his stool]. | | 1987 | 3613229 |
| identification by gas chromatography-mass spectrometry of short-chain hydroxy acids produced by fusobacterium species and clostridium innocuum. | | 1987 | 3667812 |
| effect of moxalactam on human fecal microflora. | five healthy male adults received 2 g of moxalactam every 12 h for 7 days. the alterations of fecal microflora were investigated before, during, and after treatment with moxalactam. on day 7 of treatment, the number of total bacteria was decreased in all subjects. there was marked suppression of the obligate anaerobic bacteria and enterobacteria to undetectable levels, but the counts of streptococcus spp. and lactobacillus spp. increased. on day 7, two subjects had clostridium innocuum and clost ... | 1986 | 3729329 |
| characterization of delta 4-3-ketosteroid-5 beta-reductase and 3 beta-hydroxysteroid dehydrogenase in cell extracts of clostridium innocuum. | cell extracts prepared anaerobically from clostridium innocuum and clostridium paraputrificum reduced delta 4-3-ketosteroids to 3 beta 5 beta and 3 alpha 5 beta derivatives, respectively. delta 4-3-ketosteroid-5 beta-reductase (5 beta-reductase) from both organisms required nadh for activity. 5 beta-reductase from c. innocuum had a ph optimum of 5.0. the substrate concentration at half-maximal reaction velocity was 4.2 microm, and a specific activity of 17 nmol product formed/h per mg protein wa ... | 1985 | 3861198 |
| antibacterial activity of cefminox against anaerobes. | the antibacterial activity of cefminox (cmnx) against anaerobic bacteria was studied in vitro. the results are as follows: 1. cmnx exerted antibacterial activity against a wide range of anaerobes, excluding clostridium innocuum. the antibacterial activity of cmnx against bacteroides fragilis was comparable to that of latamoxef and superior to cefoxitin, but cmnx's activity against anaerobic cocci was slightly inferior to cefoxitin's; 2. a comparison of the mics and mbcs of cmnx indicated that th ... | 1985 | 3874857 |
| the "clostridial effect" of selective decontamination of the human gut with trimethoprim/sulphamethoxazole in neutropenic patients. | during 59 periods of hospitalisation, 39 patients with either acute myeloid leukemia (22), acute lymphatic leukemia (9), acute undifferentiated leukemia (1), blastic crisis of chronic myeloid leukemia (6) or high-grade malignant non-hodgkin lymphoma (1) were subjected to aggressive polychemotherapy after selective decontamination of the gut. the patients were given an amphotericin b suspension in a dosage of 1.2 g/day for two days, after which one tablet of trimethoprim/sulphamethoxazole (tmp/sm ... | 1983 | 6352509 |
| reduction of 17-keto steroids by anaerobic microorganisms isolated from human fecal flora. | the 17-keto function of phenolic steroids is reduced by the following intestinal bacteria: eubacterium lentum, clostridium paraputrificum, clostridium j-1 and clostridium innocuum. the 17-keto group of androstenedione is reduced solely by bacteroides fragilis. | 1984 | 6477942 |
| bacterial formation of aldosterone metabolites. | the experiments described in this paper demonstrate that most of the metabolic alterations of the aldosterone molecule, hitherto attributed to hepatic enzymes, equally well may be carried out by enzymes synthesized by anaerobic bacteria from the human gut. the steroid reductases synthesized by clostridium paraputrificum, clostridium j-1, and clostridium innocuum convert aldosterone to the 3 alpha, 5 beta tetrahydroaldosterone (tha), 3 beta, 5 alpha-tha, and 3 alpha, 5 alpha-tha, respectively. al ... | 1984 | 6513554 |
| (s)-2-amino-1,3-propanediol-3-phosphate-carrying diradylglyceroglycolipids. novel major membrane lipids of clostridium innocuum. | two novel aminophosphoglycolipids (i, ii) were isolated from clostridium innocuum which constitute 51% (i) and 15% (ii) of total polar membrane lipids. the structures, established by quantitative and methylation analyses, fast-atom-bombardment mass spectrometry, and one- and two-dimensional nmr spectroscopy, are (i) s-2-amino-1,3-propanediol-3-phospho-6-alpha-d-galactopyranosyl(1-2)alpha -d- glucopyranosyl(1-3)diradylglycerol and (ii) an acylated derivative of (i) that carries an additional fatt ... | 1994 | 8055966 |
| isolation and characterization of new phosphatidylglycerol acetals of plasmalogens. a family of ether lipids in clostridia. | a new phosphatidylglycerol acetal of cardiolipin plasmalogen has been isolated from clostridium innocuum. the structure was derived from the results of quantitative group analyses, the identification of the products of acid hydrolysis, alkaline methanolysis, hydrolysis by a cardiolipin-specific phospholipase d and by one- and two-dimensional proton nmr. two other minor ether phospholipids: the lyso form of the phosphatidylglycerol acetal of cardiolipin plasmalogen, and the phosphatidylglycerol a ... | 1994 | 8055972 |
| novel polar lipid composition of clostridium innocuum as the basis for an assessment of its taxonomic status. | the extractable polar lipids of clostridium innocuum have been shown to consist of glycosyldiradylglycerols, phospholipids and phosphoglycolipids. the major glycosyldiradylglycerols are d-glcp(alpha 1-3)radyl2gro and d-galp(alpha 1-2)d-glcp(alpha 1-3)radyl2gro. both glycolipids have some 1-o-(alk-1-enyl)-2-o-acyl species, in addition to diacyl species. the phospholipids include bisphosphatidylglycerol (cardiolipin), lysocardiolipin and phosphatidylglycerol (pg). in addition, several novel lipids ... | 1994 | 8162181 |
| antimicrobial resistance in human oral and intestinal anaerobic microfloras. | in the present study we determined the resistance patterns of anaerobic bacteria from human saliva and stool specimens and investigated whether there were significant differences in resistance between outpatients and hospitalized patients, regardless of whether they had received antimicrobial agents. no bacterial strains resistant to ampicillin, piperacillin, cefoxitin, cefuroxime, imipenem, clindamycin, doxycycline, chloramphenicol, or metronidazole were isolated from the saliva samples. howeve ... | 1993 | 8215280 |
| how far should a clinical laboratory go in identifying anaerobic isolates, and who should pay? | identification of anaerobic bacteria in specimens from sites of infection due to mixed organisms can be time-consuming and expensive. laboratories should limit anaerobic workups by testing only those specimens that have been properly collected and transported to the laboratory. use of selective and differential media for initial processing can provide rapid and relevant information to the clinician. anaerobes isolated from normally sterile sites and sites of serious infection should always be co ... | 1993 | 8324163 |
| development of a selective and sensitive polymerase chain reaction assay for the detection of mycoplasma pirum. | a new assay using the polymerase chain reaction to amplify a 173-nucleotide dna fragment within the 16s ribosomal rna gene of mycoplasma pirum has been developed. the assay selectively amplified dna from all strains of m. pirum tested with a high level of sensitivity, even in a context of human dna. dna from other mollicute species, including those closely related to m. pirum, from bacteria phylogenetically close to mollicutes (clostridium innocuum, c. ramosum and bacillus subtilis), from escher ... | 1993 | 8454198 |
| identification and antimicrobial resistance patterns of clinical isolates of clostridium clostridioforme, clostridium innocuum, and clostridium ramosum compared with those of clinical isolates of clostridium perfringens. | clostridium ramosum, c. innocuum, and c. clostridioforme are frequently isolated from clinical specimens including blood. because of gram stain variability, a lack of spores, and atypical colonial morphology, identification of these species is often difficult. three anaerobe identification kits were evaluated for their abilities to identify these species. for comparison, 11 strains of c. perfringens were evaluated in parallel. by using profile numbers and codebooks, the correct genus and species ... | 1995 | 8586704 |
| clostridium innocuum endocarditis. | clostridial endocarditis is rare. we describe, to our knowledge, the first case of clostridium innocuum endocarditis. the fatal case involved the tricuspid and pulmonary valves and was associated with multiple pulmonary emboli. we review the literature, which suggests the varied presentations and outcomes of clostridial endocarditis. penicillin is the treatment of choice for this disease. | 1995 | 8589163 |
| influence of lipoteichoic acid structure on recognition by the macrophage scavenger receptor. | lipoteichoic acids (ltas) belong to the immunostimulatory class of molecules of gram-positive bacteria (gpb). previous investigations showed that the macrophage scavenger receptor (sr), a glycosylated trimeric transmembrane protein, binds directly to many gpb, possibly via lta. sr binding to other ligands is dependent upon the spatial characteristics of the repeating negative charge of the ligand. we therefore investigated sr recognition of lta species with various charge densities and distribut ... | 1996 | 8757870 |
| incidence of diarrhea with antibiotics and the increase of clostridia in rabbits. | rabbits were treated with a single intravenous injection of various antibiotics. more than 40 per cent of the animals showed diarrhea after being treated with sulbactam/cefoperazone, cefmetazole, clindamycin, piperacillin or aspoxicillin. clostridium difficile was isolated from sulbactam/cefoperazone-treated diarrheic rabbits, with their cecal contents showing positive reaction in a latex agglutination test for c. difficile enterotoxin. however, 27 cefmetazole-induced diarrheic cases were not as ... | 1996 | 8996700 |
| quantification of antigen-specific immunoglobulin a after oral booster immunization with ovalbumin in mice mono-associated with segmented filamentous bacteria or clostridium innocuum. | segmented filamentous bacteria (sfb) are known to stimulate the mucosal immune system. here, the effect of sfb on oral booster immunization with ovalbumin was investigated. mice mono-associated with sfb or clostridium innocuum were sensitized by intraperitoneal administration of 100 micrograms ovalbumin with freunds complete adjuvant. after 4 weeks, mice received 80 mg ovalbumin orally. a maximum iga response was found 5 days after this booster immunization. comparison of mice with sfb and mice ... | 1997 | 9436465 |
| low-level vancomycin resistance in clostridium innocuum. | low-level vancomycin resistance was observed for 28 clinical clostridium innocuum isolates and c. innocuum ncib 10674, whereas teicoplanin was active. dna from three clinical isolates and the type strain could not be amplified by pcr with primers specific for the genes vana, vanb, and vanc, suggesting that c. innocuum is intrinsically resistant to vancomycin. | 1998 | 9620417 |
| in vitro activity of gemifloxacin (sb 265805) against anaerobes. | gemifloxacin mesylate (sb 265805), a new fluoronaphthyridone, was tested against 359 recent clinical anaerobic isolates by the national committee for clinical laboratory standards reference agar dilution method with supplemented brucella blood agar and an inoculum of 10(5) cfu/spot. comparative antimicrobials tested included trovafloxacin, levofloxacin, grepafloxacin, sparfloxacin, sitafloxacin (du-6859a), penicillin g, amoxicillin clavulanate, imipenem, cefoxitin, clindamycin, and metronidazole ... | 1999 | 10471570 |
| activities of gemifloxacin (sb 265805, lb20304) compared to those of other oral antimicrobial agents against unusual anaerobes. | the activities of gemifloxacin (sb 265805, lb20304) and comparator agents were determined by an agar dilution method against 419 clinical strains of less-commonly identified species of anaerobes. gemifloxacin was generally more active than trovafloxacin against gram-positive strains by one to two dilutions. peptostreptococci (peptostreptococcus asaccharolyticus, peptostreptococcus magnus, peptostreptococcus micros, and peptostreptococcus prevotii) and porphyromonas spp. (porphyromonas asaccharol ... | 1999 | 10543754 |
| clostridium innocuum: a glucoseureide-splitting inhabitant of the human intestinal tract. | glycosylureides were recently described as non-invasive markers of intestinal transit time. the underlying principle is an enzymatic splitting of (13)c-labelled ureides by intestinal bacteria. the (13)co(2) released from the urea moiety of the glycosylureides can be measured in breath samples when the ingested tracer substrate reaches the caecum that is colonised with microbes. to date, the microbes that degrade glycosylureides are unknown. in order to identify the glucoseureide (gu)-splitting b ... | 1999 | 10564769 |
| hasty effect on the metabolism of glycyrrhizin by eubacterium sp. glh with ruminococcus sp. po1-3 and clostridium innocuum es24-06 of human intestinal bacteria. | eubacterium sp. glh with ruminococcus sp. po1-3 and clostridium innocuum es24-06 possessing enzymes involved in the metabolism of glycyrrhizin (gl) was cultured in gam medium with and without 1.0 mm gl or 1.0 mm glycyrrhetic acid (ga). gl (1.0 mm) enhanced 3alpha-hydroxyglycyrrhetinate (3alpha-hydroxyga) dehydrogenase activity, ga (1.0 mm) suppressed 3alpha-hydroxyga dehydrogenase activity, gl beta-d-glucuronidase activity and the mixed bacterial growth, and gl and ga showed almost no change in ... | 2000 | 10706402 |
| enterococcal vanb resistance locus in anaerobic bacteria in human faeces. | while developing a rapid method to detect carriers of vancomycin-resistant enterococci (vre), we found the vanb gene by pcr in 13 of 50 human faecal specimens that did not contain culturable vre. passaging under antibiotic selection allowed us to isolate two species of anaerobic bacteria that were vanb pcr positive, vancomycin resistant, and teicoplanin sensitive. sequence analysis of the 16s rrna genes showed that one isolate resembled eggerthella lenta (98% identity), and the other clostridium ... | 2001 | 11265957 |
| isolation of clostridium innocuum from cases of recurrent diarrhea in patients with prior clostridium difficile associated diarrhea. | clostridium innocuum isolates resistant to vancomycin (mic values of 16-24 microg/ml) were isolated from three patients with recurrent clostridium difficile -associated diarrhea (cdad). we discuss the clinical significance and problems associated with the identification and differentiation of these two clostridial species, which may result in misdiagnosis of patients. | 2001 | 11502376 |
| comparative in vitro activities of ertapenem (mk-0826) against 469 less frequently identified anaerobes isolated from human infections. | we studied the in vitro activity of ertapenem against 469 less frequently identified anaerobes from 11 genera and 52 species isolated from human infections. ertapenem was uniformly active against 460 of 469 (98%) strains at concentrations of < or = 4 microg/ml. only 4 of 14 clostridium difficile, 1 of 11 clostridium innocuum, and 4 of 6 lactobacillus sp. strains required ertapenem concentrations of > or = 8 microg/ml for inhibition. | 2002 | 11897608 |
| arylsulfotransferase from clostridium innocuum-a new enzyme catalyst for sulfation of phenol-containing compounds. | arylsulfotransferase (ast, ec 2.8.2.22), an enzyme capable of sulfating a wide range of phenol-containing compounds was purified from a clostridium innocuum isolate (strain 554). the enzyme has a molecular weight of 320 kda and is composed of four subunits. unlike many mammalian and plant arylsulfotransferases, ast from clostridium utilizes arylsulfates, including p-nitrophenyl sulfate, as sulfate donors, and is not reactive with 3-phosphoadenosine-5'-phosphosulfate (paps). the enzyme possesses ... | 2002 | 12115126 |
| in vitro activities of daptomycin, vancomycin, quinupristin- dalfopristin, linezolid, and five other antimicrobials against 307 gram-positive anaerobic and 31 corynebacterium clinical isolates. | the activities of daptomycin, a cyclic lipopeptide, and eight other agents were determined against 338 strains of gram-positive anaerobic bacteria and corynebacteria by the nccls reference agar dilution method with supplemented brucella agar for the anaerobes and mueller-hinton agar for the corynebacteria. the daptomycin mics determined on ca(2+)-supplemented (50 mg/liter) brucella agar plates were one- to fourfold lower than those determined in unsupplemented media. daptomycin was highly active ... | 2003 | 12499210 |
| in vitro activities of ramoplanin, teicoplanin, vancomycin, linezolid, bacitracin, and four other antimicrobials against intestinal anaerobic bacteria. | by using an agar dilution method, the in vitro activities of ramoplanin, teicoplanin, vancomycin, linezolid, and five other agents were determined against 300 gram-positive and 54 gram-negative strains of intestinal anaerobes. ramoplanin was active at <or=2 microg/ml against 287 of 300 (95.7%) gram-positive organisms, including 18 strains of clostridium difficile for which mics of ramoplanin were 0.25 to 0.5 microg/ml; for 3 of these, linezolid mics were 8 to 16 micro g/ml. nineteen clostridium ... | 2003 | 12821492 |
| clostridium innocuum, sp. n., a sporeforming anaerobe isolated from human infections. | | 1962 | 13914326 |
| clostridium innocuum bacteremia secondary to infected hematoma with gas formation in a kidney transplant recipient. | clostridium innocuum is a relatively antimicrobial resistant, frequently misidentified anaerobe that has only rarely been associated with bacteremia. a 38-year-old female with chronic hepatitis c underwent a second kidney transplant operation. two weeks after surgery a computed tomography scan of the abdomen showed a heterogeneous hematoma with pockets of gas adjacent to the allograft, which extended into the pelvis and left abdominal wall, associated with low-grade fever. an anaerobic blood cul ... | 2003 | 14987206 |
| mechanism of intrinsic resistance to vancomycin in clostridium innocuum ncib 10674. | we have studied the basis for intrinsic resistance to low levels of vancomycin in clostridium innocuum ncib 10674 (mic = 8 microg/ml). analysis by high-pressure liquid chromatography (hplc) and mass spectrometry of peptidoglycan nucleotide precursors pools revealed the presence of two types of udp-murnac-pentapeptide precursors constitutively produced, an udp-murnac-pentapeptide with a serine at the c terminus which represented 93% of the pool and an udp-murnac-pentapeptide with an alanine at th ... | 2004 | 15150227 |
| in vitro activities of the new semisynthetic glycopeptide telavancin (td-6424), vancomycin, daptomycin, linezolid, and four comparator agents against anaerobic gram-positive species and corynebacterium spp. | telavancin is a new semisynthetic glycopeptide anti-infective with multiple mechanisms of action, including inhibition of bacterial membrane phospholipid synthesis and inhibition of bacterial cell wall synthesis. we determined the in vitro activities of telavancin, vancomycin, daptomycin, linezolid, quinupristin-dalfopristin, imipenem, piperacillin-tazobactam, and ampicillin against 268 clinical isolates of anaerobic gram-positive organisms and 31 corynebacterium strains using agar dilution meth ... | 2004 | 15155214 |
| comparison of three pcr primer sets for identification of vanb gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanb-containing anaerobic bacilli. | we assessed the sensitivities and specificities of three previously described pcr primers on enrichment broth cultures of feces for the accurate detection of fecal carriage of vancomycin-resistant enterococci (vre). in addition, we investigated specimens that were vanb pcr positive but vre culture negative for the presence of other vanb-containing pathogens. feces from 59 patients (12 patients carrying vanb enterococcus faecium strains and 47 patients negative for vre carriage) were cultured for ... | 2005 | 15616278 |
| allobaculum stercoricanis gen. nov., sp. nov., isolated from canine feces. | morphological, biochemical, and molecular genetic studies were performed on an unknown anaerobic, catalase-negative, non-spore-forming, rod-shaped bacterium isolated from dog feces. the unknown bacterium was tentatively identified as a eubacterium species, based on cellular morphological and biochemical tests. 16s rrna gene sequencing studies, however, revealed that it was phylogenetically distant from eubacterium limosum, the type species of the genus eubacterium. phylogenetically, the unknown ... | 2004 | 16701531 |
| infection after elective colorectal surgery: bacteriological analysis of failures in a randomized trial of cefotetan vs. ertapenem prophylaxis. | a randomized study comparing single-dose cefotetan and ertapenem prophylaxis for elective colorectal surgery in 1,002 patients found ertapenem to be significantly more effective (p < 0.001). failures of prophylaxis were thought to involve organisms resistant to both antimicrobial agents, isolated most often from deep or superficial incision sites. | 2009 | 19226203 |
| epidemiology and outcomes of clostridial bacteremia at a tertiary-care institution. | a review was performed to determine the epidemiology and outcomes of clostridial bacteremia (cb) at our institution. ninety-two percent of patients had monomicrobial cb. patients with clostridium innocuum bacteremia had a significantly higher 2-day mortality rate compared to patients with c. septicum and c. perfringens. cb is associated with high and rapid mortality, especially in patients with malignancy. early mortality was significantly lower in patients receiving antibiotics with adequate co ... | 2009 | 19252754 |
| clostridium innocuum bacteremia in a patient with acquired immunodeficiency syndrome. | clostridium innocuum is an unusual cause of infections in humans. this report describes the first published case of c. innocuum bacteremia in a patient with aids and provides a review of the literature. the case suggests that recent c. difficile infection may be a risk factor for the subsequent development of c. innocuum bacteremia among immunosuppressed persons. because of their intrinsic resistance to several common antibiotics, including vancomycin, c. innocuum infections are important to rec ... | 2009 | 19525665 |
| molecular inventory of faecal microflora in patients with crohn's disease. | intestinal microbial community is involved in the pathogenesis of crohn's disease, but knowledge of its potential abnormalities has been limited by the impossibility to grow many dominant intestinal bacteria. using sequence analysis of randomly cloned bacterial 16s ribosomal dna, the dominant faecal species from four crohn's disease patients and four controls were compared. whereas marked inter-individual differences were observed in the faecal microflora of patients, three remained distantly re ... | 2004 | 19712374 |
| isolation of bacteria from mouse caecal samples and description of bacteroides sartorii sp. nov. | caecal samples from wild-type and tnf(deltaare) mice were cultured on selective media containing bile salts, amino acids or casein macro-peptides. twenty-two strains were isolated and identified by 16s rrna gene sequencing. twenty-one strains showed >98% similarity to known bacteria (blautia spp., clostridium innocuum, enterococcus spp., escherichia coli, lactobacillus murinus, parabacteroides goldsteinii and shigella dysenteriae). one additional isolate, strain a-c2-0, was a new bacterium. the ... | 2010 | 20369227 |
| intestinal steroid profiles and microbiota composition in colitic mice. | reduced gut microbiota diversity in conjunction with a bloom of few bacterial species is a common feature in inflammatory bowel disease (ibd) patients. however, the environmental changes caused by inflammation and their possible impact on the microbiota are largely unknown. since ibd is associated with an impaired intestinal steroid metabolism, we hypothesized that changes in intestinal steroid and particularly bile acid (ba) concentrations affect microbial communities. we used interleukin-10 de ... | 2011 | 21869607 |
| gut microbiome in sudden infant death syndrome (sids) differs from that in healthy comparison babies and offers an explanation for the risk factor of prone position. | the role of bacteria in the causation of sudden infant death syndrome (sids) is gaining acceptance. mainstream research favouring respiratory compromise has failed to provide a plausible pathogenetic mechanism despite many years of investigation and thousands of research papers. bacterial colonisation of the colon of the human infant is influenced by many factors including age, mode of delivery, diet, environment, and antibiotic exposure. the gut microbiome influences development of the immune s ... | 2014 | 24951305 |
| vancomycin-resistant clostridium innocuum bacteremia following oral vancomycin for clostridium difficile infection. | an 85 year-old male initially admitted for septic shock due to urinary tract infection experienced clostridium difficile-associated diarrhea during hospitalization and was treated by oral vancomycin. his clinical course was complicated by cytomegalovirus colitis and then vancomycin-resistant clostridium innocuum bacteremia, which was cured by uneventfully parenteral piperacillin-tazobactam therapy. | 2014 | 25102472 |
| comparative in vitro activities of lff571 against clostridium difficile and 630 other intestinal strains of aerobic and anaerobic bacteria. | the in vitro activities of lff571, a novel analog of ge2270a that inhibits bacterial growth by binding with high affinity for protein synthesis elongation factor tu, fidaxomicin, and 10 other antimicrobial agents were determined against 50 strains of clostridium difficile and 630 other anaerobic and aerobic organisms of intestinal origin. lff571 possesses potent activity against c. difficile and most other gram-positive anaerobes (mic(90), ≤ 0.25 μg/ml), with the exception of bifidobacteria and ... | 2012 | 22290948 |
| clostridium innocuum is a significant vancomycin-resistant pathogen for extra-intestinal clostridial infection. | extra-intestinal clostridial infection (eici) is rare but can be fatal. traditional phenotypic methods can only assign many of the clostridium species to the genus level. | 2017 | 28254687 |
| osteomyelitis due to clostridium innocuum in a patient with acute lymphoblastic leukemia: case report and literature review. | clostridium innocuum is an anaerobic gram-positive bacterium, unable to produce toxins and rarely causes infections. we report the first case of c. innocuum osteomyelitis and bacteremia in a patient with acute lymphoblastic leukemia (all). findings were compared with previously reported cases of c. innocuum infections in immunocompromised patients, e.g., patients with acquired immune deficiency syndrome, leukemia, and organ transplantation. | 2015 | 26240783 |
| early colonizing escherichia coli elicits remodeling of rat colonic epithelium shifting toward a new homeostatic state. | we investigated the effects of early colonizing bacteria on the colonic epithelium. we isolated dominant bacteria, escherichia coli, enterococcus faecalis, lactobacillus intestinalis, clostridium innocuum and a novel fusobacterium spp., from the intestinal contents of conventional suckling rats and transferred them in different combinations into germfree (gf) adult rats. animals were investigated after various times up to 21 days. proliferative cell markers (ki67, proliferating cell nuclear anti ... | 2015 | 25012905 |